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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAP1L4-NUTM1 (FusionGDB2 ID:56863)

Fusion Gene Summary for NAP1L4-NUTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L4-NUTM1
Fusion gene ID: 56863
HgeneTgene
Gene symbol

NAP1L4

NUTM1

Gene ID

4676

256646

Gene namenucleosome assembly protein 1 like 4NUT midline carcinoma family member 1
SynonymsNAP1L4b|NAP2|NAP2L|hNAP2C15orf55|FAM22H|NUT
Cytomap

11p15.4

15q14

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2NUT family member 1nuclear protein in testis
Modification date2020032220200313
UniProtAcc

Q99733

Q86Y26

Ensembl transtripts involved in fusion geneENST00000380542, ENST00000469089, 
ENST00000526115, 
ENST00000537011, 
ENST00000438749, ENST00000333756, 
Fusion gene scores* DoF score13 X 18 X 7=16386 X 5 X 4=120
# samples 185
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAP1L4 [Title/Abstract] AND NUTM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAP1L4(2980998)-NUTM1(34645936), # samples:1
Anticipated loss of major functional domain due to fusion event.NAP1L4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NAP1L4-NUTM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NAP1L4-NUTM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAP1L4

GO:0006334

nucleosome assembly

9325046


check buttonFusion gene breakpoints across NAP1L4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AMF571888NAP1L4chr11

2980998

-NUTM1chr15

34645936

+


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Fusion Gene ORF analysis for NAP1L4-NUTM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380542ENST00000537011NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
Frame-shiftENST00000380542ENST00000438749NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
Frame-shiftENST00000380542ENST00000333756NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
intron-3CDSENST00000469089ENST00000537011NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
intron-3CDSENST00000469089ENST00000438749NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
intron-3CDSENST00000469089ENST00000333756NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
In-frameENST00000526115ENST00000537011NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
In-frameENST00000526115ENST00000438749NAP1L4chr11

2980998

-NUTM1chr15

34645936

+
In-frameENST00000526115ENST00000333756NAP1L4chr11

2980998

-NUTM1chr15

34645936

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000526115NAP1L4chr112980998-ENST00000537011NUTM1chr1534645936+3812103028435741096
ENST00000526115NAP1L4chr112980998-ENST00000438749NUTM1chr1534645936+3821103028435741096
ENST00000526115NAP1L4chr112980998-ENST00000333756NUTM1chr1534645936+3816103028435741096

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000526115ENST00000537011NAP1L4chr112980998-NUTM1chr1534645936+0.0038812140.9961188
ENST00000526115ENST00000438749NAP1L4chr112980998-NUTM1chr1534645936+0.0039007640.99609923
ENST00000526115ENST00000333756NAP1L4chr112980998-NUTM1chr1534645936+0.0038510370.99614894

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Fusion Genomic Features for NAP1L4-NUTM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAP1L4chr112980999-NUTM1chr1534645936+1.02E-070.9999999
NAP1L4chr112980999-NUTM1chr1534645936+1.02E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAP1L4-NUTM1


check button Go to

FGviewer for the breakpoints of chr11:2980998-chr15:34645936

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L4

Q99733

NUTM1

Q86Y26

FUNCTION: Acts as histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.FUNCTION: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269|PubMed:30447097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAP1L4chr11:2980998chr15:34645936ENST00000380542-916126_131248.66666666666666740.3333333333334Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAP1L4chr11:2980998chr15:34645936ENST00000380542-916301_310248.66666666666666740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2980998chr15:34645936ENST00000380542-916347_370248.66666666666666740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2980998chr15:34645936ENST00000380542-916265_271248.66666666666666740.3333333333334MotifNuclear localization signal
TgeneNUTM1chr11:2980998chr15:34645936ENST000003337562710_182284.66666666666671133.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for NAP1L4-NUTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000526115_ENST00000537011_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(transcript)=3812nt_BP=1030nt
CTTGCTCGCGGAGAGAGGAGCTAGGAGCCTCGGCCAATGGGAGCCGGCGTTGTTGGAGGCCACGGCGGCGCAGCCCCAAAGCGAGCGAAG
CTAGGGTCGCCGCCACTGCCGCAGGAGGCGTGAGGGAAAAGTGTTTTAGGCTTCCAGAGTAGAAATCTGATATTACTTCGTTTGATTCTT
CGACCACTATGGTGATAGGAAGTAGCTGATCTCTGCAGGAAACTGCTGTTACCTGGCCTCAGCTGAATTTTTGTGGGACCTCCTGAGGGG
ATAAAAACATTCAGATGGCAGATCACAGTTTTTCAGATGGGGTTCCTTCAGATTCCGTGGAAGCTGCTAAAAATGCAAGTAACACAGAAA
AGCTCACAGATCAGGTGATGCAGAATCCTCGAGTTCTGGCAGCTTTACAGGAGCGACTTGACAATGTCCCTCACACCCCTTCCAGCTACA
TCGAAACTTTACCTAAAGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCCAAGTTCTATG
AAGAGGTACATGACTTGGAAAGAAAGTATGCAGCGCTATACCAGCCTCTCTTTGACAAGAGAAGAGAATTTATCACCGGCGATGTTGAAC
CAACAGATGCGGAATCGGAATGGCACAGTGAAAATGAAGAGGAAGAGAAATTGGCTGGAGACATGAAAAGTAAAGTAGTCGTCACAGAAA
AAGCAGCGGCAACGGCTGAAGAGCCAGATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTCAGAAATGTGGACATGCTGAGTGAAT
TAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAATTTTCTGACCCTGGACAGCCTATGTCTTTTGTGT
TAGAGTTCCACTTTGAACCCAACGACTACTTTACCAACTCAGTCCTGACAAAAACCTACAAGATGAAATCAGAACCAGATAAGGCTGATC
CCTTTTCCTTTGAAGGTCCTGAGATTGTGGACTGTGACGGGTTCATGGAGTTTGAGGCTGAGGAGATGCAGATTCAGAACACACAGCTGA
TGAATGGGTCTCAGGGCCTGTCTCCTGCAACCCCTTTGAAACTTGATCCTCTAGGGCCCCTGGCCTCTGAGGTTTGCCAGCAGCCAGTGT
ACATTCCGAAGAAGGCAGCCTCCAAGACACGGGCCCCCCGCCGGCGTCAGCGTAAAGCCCAGAGACCTCCTGCTCCTGAGGCACCCAAGG
AGATCCCACCAGAAGCTGTGAAGGAGTATGTTGACATCATGGAATGGCTGGTGGGGACTCACTTGGCCACTGGGGAGTCAGATGGAAAAC
AAGAGGAAGAAGGGCAGCAGCAGGAGGAGGAAGGGATGTATCCAGATCCAGGTCTCCTGAGCTACATCAATGAGCTGTGTTCTCAGAAGG
TCTTTGTCTCCAAGGTGGAGGCTGTCATTCACCCTCAATTTCTGGCAGATCTGCTGTCCCCAGAAAAACAGAGAGATCCCTTGGCCTTAA
TTGAGGAGCTAGAGCAAGAAGAAGGACTCACTCTTGCCCAGCTGGTCCAGAAGCGACTCATGGCCTTGGAAGAGGAGGAAGATGCAGAGG
CGCCTCCAAGTTTCAGTGGCGCTCAGTTGGACTCAAGTCCTTCTGGTTCTGTTGAGGATGAAGATGGGGATGGGCGGCTTCGGCCCTCAC
CTGGGCTTCAGGGGGCTGGGGGCGCCGCTTGCCTTGGAAAGGTTTCTTCTTCAGGAAAACGGGCAAGAGAAGTGCATGGTGGGCAGGAGC
AAGCCCTAGATAGCCCCAGAGGGATGCACAGGGATGGGAACACTCTGCCATCCCCCAGCAGCTGGGACCTGCAGCCAGAACTTGCAGCTC
CACAGGGAACTCCGGGACCCTTGGGTGTGGAGAGGAGAGGGTCTGGGAAGGTTATAAACCAGGTATCTCTACATCAGGATGGCCATCTAG
GAGGCGCTGGGCCTCCTGGGCACTGCCTGGTGGCTGATAGGACTTCAGAGGCTCTGCCCCTTTGTTGGCAGGGAGGCTTCCAGCCTGAGA
GCACTCCCAGTTTGGATGCTGGACTTGCAGAGCTGGCTCCTCTGCAAGGACAAGGGTTAGAAAAGCAAGTCCTGGGATTGCAGAAAGGAC
AACAAACAGGGGGTCGTGGAGTGCTTCCTCAAGGGAAGGAGCCTTTAGCAGTGCCCTGGGAAGGCTCTTCAGGAGCCATGTGGGGAGATG
ACAGAGGTACCCCCATGGCTCAGAGTTATGATCAGAATCCTTCCCCTAGAGCAGCTGGGGAGAGGGACGATGTCTGTCTCAGCCCAGGAG
TTTGGCTGAGCAGTGAGATGGATGCTGTAGGCTTGGAGCTGCCTGTACAAATAGAGGAGGTCATAGAGAGCTTCCAAGTTGAGAAGTGTG
TAACTGAGTATCAGGAAGGCTGCCAGGGACTGGGCTCCAGGGGCAACATTTCCCTGGGTCCTGGAGAAACCCTAGTACCTGGGGATACGG
AGAGCAGTGTGATTCCCTGTGGAGGCACAGTTGCGGCAGCTGCCCTAGAAAAGAGAAACTATTGCAGCTTGCCAGGACCTTTGAGGGCCA
ACAGCCCACCCTTGAGGTCCAAAGAAAATCAAGAACAGAGCTGTGAAACCGTAGGGCATCCCAGTGATCTGTGGGCAGAAGGTTGCTTCC
CATTGCTAGAAAGTGGTGATTCCACACTGGGGTCTTCCAAAGAAACCCTTCCACCCACATGCCAAGGCAATCTCCTTATCATGGGGACTG
AGGATGCCTCCTCCTTGCCTGAAGCCAGTCAAGAGGCAGGGAGCAGAGGCAATTCCTTTTCTCCTCTGTTGGAAACCATAGAACCTGTCA
ACATACTAGATGTTAAAGATGACTGTGGCCTCCAACTAAGGGTCAGCGAGGACACCTGCCCACTGAATGTTCATTCTTATGACCCCCAAG
GAGAAGGCAGGGTGGATCCTGATCTGTCCAAGCCTAAAAACCTTGCTCCTTTACAAGAGAGTCAGGAGTCTTACACAACTGGGACTCCCA
AAGCAACATCTTCTCACCAGGGCCTTGGAAGCACTTTGCCTAGAAGGGGAACCAGGAATGCCATAGTTCCGAGAGAAACTTCTGTTAGTA
AAACACACAGGTCAGCAGACAGGGCCAAAGGAAAGGAGAAAAAGAAAAAGGAAGCAGAGGAAGAGGATGAGGAACTCTCCAACTTTGCTT
ACCTCTTGGCCTCTAAACTTAGCCTCTCACCAAGGGAGCATCCCCTCAGTCCTCACCATGCCTCAGGAGGTCAGGGCAGCCAGAGAGCAT
CCCACCTGCTCCCTGCTGGAGCAAAAGGCCCCAGCAAACTTCCATATCCTGTTGCCAAGTCTGGGAAGCGAGCTCTAGCTGGAGGTCCAG
CCCCTACTGAAAAGACACCCCACTCAGGAGCTCAACTTGGGGTCCCCAGGGAGAAACCCCTAGCTCTGGGAGTAGTTCGACCCTCACAGC
CTCGTAAAAGGCGGTGTGACAGTTTTGTCACGGGCAGAAGGAAGAAACGACGTCGTAGCCAGTAGGGAGCAGCGGGACCATCTGACCCCA
CTTGCCAGTCCCTAAAGGTGGGTGCCCCAGAGTAGATTCCACCCCTGCTGCCCACCAATGGAGAATCCCAATGTTGAATCTCATCCCAAT
GTTGTTTTGTTGTTCTGCAAAAGTGGCAAGCATGGAGAGAGAGGTCAGACTGGCTAGGCTGCAGGGGGAATTACCTTTGGAAGGAGCTAT

>In-frame_ENST00000526115_ENST00000537011_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(amino acids)=1096AA_start in transcript=284_stop in transcript=3574
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGFMEFEAEEMQIQNTQLMNGSQ
GLSPATPLKLDPLGPLASEVCQQPVYIPKKAASKTRAPRRRQRKAQRPPAPEAPKEIPPEAVKEYVDIMEWLVGTHLATGESDGKQEEEG
QQQEEEGMYPDPGLLSYINELCSQKVFVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQEEGLTLAQLVQKRLMALEEEEDAEAPPSF
SGAQLDSSPSGSVEDEDGDGRLRPSPGLQGAGGAACLGKVSSSGKRAREVHGGQEQALDSPRGMHRDGNTLPSPSSWDLQPELAAPQGTP
GPLGVERRGSGKVINQVSLHQDGHLGGAGPPGHCLVADRTSEALPLCWQGGFQPESTPSLDAGLAELAPLQGQGLEKQVLGLQKGQQTGG
RGVLPQGKEPLAVPWEGSSGAMWGDDRGTPMAQSYDQNPSPRAAGERDDVCLSPGVWLSSEMDAVGLELPVQIEEVIESFQVEKCVTEYQ
EGCQGLGSRGNISLGPGETLVPGDTESSVIPCGGTVAAAALEKRNYCSLPGPLRANSPPLRSKENQEQSCETVGHPSDLWAEGCFPLLES
GDSTLGSSKETLPPTCQGNLLIMGTEDASSLPEASQEAGSRGNSFSPLLETIEPVNILDVKDDCGLQLRVSEDTCPLNVHSYDPQGEGRV
DPDLSKPKNLAPLQESQESYTTGTPKATSSHQGLGSTLPRRGTRNAIVPRETSVSKTHRSADRAKGKEKKKKEAEEEDEELSNFAYLLAS
KLSLSPREHPLSPHHASGGQGSQRASHLLPAGAKGPSKLPYPVAKSGKRALAGGPAPTEKTPHSGAQLGVPREKPLALGVVRPSQPRKRR

--------------------------------------------------------------
>In-frame_ENST00000526115_ENST00000438749_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(transcript)=3821nt_BP=1030nt
CTTGCTCGCGGAGAGAGGAGCTAGGAGCCTCGGCCAATGGGAGCCGGCGTTGTTGGAGGCCACGGCGGCGCAGCCCCAAAGCGAGCGAAG
CTAGGGTCGCCGCCACTGCCGCAGGAGGCGTGAGGGAAAAGTGTTTTAGGCTTCCAGAGTAGAAATCTGATATTACTTCGTTTGATTCTT
CGACCACTATGGTGATAGGAAGTAGCTGATCTCTGCAGGAAACTGCTGTTACCTGGCCTCAGCTGAATTTTTGTGGGACCTCCTGAGGGG
ATAAAAACATTCAGATGGCAGATCACAGTTTTTCAGATGGGGTTCCTTCAGATTCCGTGGAAGCTGCTAAAAATGCAAGTAACACAGAAA
AGCTCACAGATCAGGTGATGCAGAATCCTCGAGTTCTGGCAGCTTTACAGGAGCGACTTGACAATGTCCCTCACACCCCTTCCAGCTACA
TCGAAACTTTACCTAAAGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCCAAGTTCTATG
AAGAGGTACATGACTTGGAAAGAAAGTATGCAGCGCTATACCAGCCTCTCTTTGACAAGAGAAGAGAATTTATCACCGGCGATGTTGAAC
CAACAGATGCGGAATCGGAATGGCACAGTGAAAATGAAGAGGAAGAGAAATTGGCTGGAGACATGAAAAGTAAAGTAGTCGTCACAGAAA
AAGCAGCGGCAACGGCTGAAGAGCCAGATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTCAGAAATGTGGACATGCTGAGTGAAT
TAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAATTTTCTGACCCTGGACAGCCTATGTCTTTTGTGT
TAGAGTTCCACTTTGAACCCAACGACTACTTTACCAACTCAGTCCTGACAAAAACCTACAAGATGAAATCAGAACCAGATAAGGCTGATC
CCTTTTCCTTTGAAGGTCCTGAGATTGTGGACTGTGACGGGTTCATGGAGTTTGAGGCTGAGGAGATGCAGATTCAGAACACACAGCTGA
TGAATGGGTCTCAGGGCCTGTCTCCTGCAACCCCTTTGAAACTTGATCCTCTAGGGCCCCTGGCCTCTGAGGTTTGCCAGCAGCCAGTGT
ACATTCCGAAGAAGGCAGCCTCCAAGACACGGGCCCCCCGCCGGCGTCAGCGTAAAGCCCAGAGACCTCCTGCTCCTGAGGCACCCAAGG
AGATCCCACCAGAAGCTGTGAAGGAGTATGTTGACATCATGGAATGGCTGGTGGGGACTCACTTGGCCACTGGGGAGTCAGATGGAAAAC
AAGAGGAAGAAGGGCAGCAGCAGGAGGAGGAAGGGATGTATCCAGATCCAGGTCTCCTGAGCTACATCAATGAGCTGTGTTCTCAGAAGG
TCTTTGTCTCCAAGGTGGAGGCTGTCATTCACCCTCAATTTCTGGCAGATCTGCTGTCCCCAGAAAAACAGAGAGATCCCTTGGCCTTAA
TTGAGGAGCTAGAGCAAGAAGAAGGACTCACTCTTGCCCAGCTGGTCCAGAAGCGACTCATGGCCTTGGAAGAGGAGGAAGATGCAGAGG
CGCCTCCAAGTTTCAGTGGCGCTCAGTTGGACTCAAGTCCTTCTGGTTCTGTTGAGGATGAAGATGGGGATGGGCGGCTTCGGCCCTCAC
CTGGGCTTCAGGGGGCTGGGGGCGCCGCTTGCCTTGGAAAGGTTTCTTCTTCAGGAAAACGGGCAAGAGAAGTGCATGGTGGGCAGGAGC
AAGCCCTAGATAGCCCCAGAGGGATGCACAGGGATGGGAACACTCTGCCATCCCCCAGCAGCTGGGACCTGCAGCCAGAACTTGCAGCTC
CACAGGGAACTCCGGGACCCTTGGGTGTGGAGAGGAGAGGGTCTGGGAAGGTTATAAACCAGGTATCTCTACATCAGGATGGCCATCTAG
GAGGCGCTGGGCCTCCTGGGCACTGCCTGGTGGCTGATAGGACTTCAGAGGCTCTGCCCCTTTGTTGGCAGGGAGGCTTCCAGCCTGAGA
GCACTCCCAGTTTGGATGCTGGACTTGCAGAGCTGGCTCCTCTGCAAGGACAAGGGTTAGAAAAGCAAGTCCTGGGATTGCAGAAAGGAC
AACAAACAGGGGGTCGTGGAGTGCTTCCTCAAGGGAAGGAGCCTTTAGCAGTGCCCTGGGAAGGCTCTTCAGGAGCCATGTGGGGAGATG
ACAGAGGTACCCCCATGGCTCAGAGTTATGATCAGAATCCTTCCCCTAGAGCAGCTGGGGAGAGGGACGATGTCTGTCTCAGCCCAGGAG
TTTGGCTGAGCAGTGAGATGGATGCTGTAGGCTTGGAGCTGCCTGTACAAATAGAGGAGGTCATAGAGAGCTTCCAAGTTGAGAAGTGTG
TAACTGAGTATCAGGAAGGCTGCCAGGGACTGGGCTCCAGGGGCAACATTTCCCTGGGTCCTGGAGAAACCCTAGTACCTGGGGATACGG
AGAGCAGTGTGATTCCCTGTGGAGGCACAGTTGCGGCAGCTGCCCTAGAAAAGAGAAACTATTGCAGCTTGCCAGGACCTTTGAGGGCCA
ACAGCCCACCCTTGAGGTCCAAAGAAAATCAAGAACAGAGCTGTGAAACCGTAGGGCATCCCAGTGATCTGTGGGCAGAAGGTTGCTTCC
CATTGCTAGAAAGTGGTGATTCCACACTGGGGTCTTCCAAAGAAACCCTTCCACCCACATGCCAAGGCAATCTCCTTATCATGGGGACTG
AGGATGCCTCCTCCTTGCCTGAAGCCAGTCAAGAGGCAGGGAGCAGAGGCAATTCCTTTTCTCCTCTGTTGGAAACCATAGAACCTGTCA
ACATACTAGATGTTAAAGATGACTGTGGCCTCCAACTAAGGGTCAGCGAGGACACCTGCCCACTGAATGTTCATTCTTATGACCCCCAAG
GAGAAGGCAGGGTGGATCCTGATCTGTCCAAGCCTAAAAACCTTGCTCCTTTACAAGAGAGTCAGGAGTCTTACACAACTGGGACTCCCA
AAGCAACATCTTCTCACCAGGGCCTTGGAAGCACTTTGCCTAGAAGGGGAACCAGGAATGCCATAGTTCCGAGAGAAACTTCTGTTAGTA
AAACACACAGGTCAGCAGACAGGGCCAAAGGAAAGGAGAAAAAGAAAAAGGAAGCAGAGGAAGAGGATGAGGAACTCTCCAACTTTGCTT
ACCTCTTGGCCTCTAAACTTAGCCTCTCACCAAGGGAGCATCCCCTCAGTCCTCACCATGCCTCAGGAGGTCAGGGCAGCCAGAGAGCAT
CCCACCTGCTCCCTGCTGGAGCAAAAGGCCCCAGCAAACTTCCATATCCTGTTGCCAAGTCTGGGAAGCGAGCTCTAGCTGGAGGTCCAG
CCCCTACTGAAAAGACACCCCACTCAGGAGCTCAACTTGGGGTCCCCAGGGAGAAACCCCTAGCTCTGGGAGTAGTTCGACCCTCACAGC
CTCGTAAAAGGCGGTGTGACAGTTTTGTCACGGGCAGAAGGAAGAAACGACGTCGTAGCCAGTAGGGAGCAGCGGGACCATCTGACCCCA
CTTGCCAGTCCCTAAAGGTGGGTGCCCCAGAGTAGATTCCACCCCTGCTGCCCACCAATGGAGAATCCCAATGTTGAATCTCATCCCAAT
GTTGTTTTGTTGTTCTGCAAAAGTGGCAAGCATGGAGAGAGAGGTCAGACTGGCTAGGCTGCAGGGGGAATTACCTTTGGAAGGAGCTAT

>In-frame_ENST00000526115_ENST00000438749_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(amino acids)=1096AA_start in transcript=284_stop in transcript=3574
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGFMEFEAEEMQIQNTQLMNGSQ
GLSPATPLKLDPLGPLASEVCQQPVYIPKKAASKTRAPRRRQRKAQRPPAPEAPKEIPPEAVKEYVDIMEWLVGTHLATGESDGKQEEEG
QQQEEEGMYPDPGLLSYINELCSQKVFVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQEEGLTLAQLVQKRLMALEEEEDAEAPPSF
SGAQLDSSPSGSVEDEDGDGRLRPSPGLQGAGGAACLGKVSSSGKRAREVHGGQEQALDSPRGMHRDGNTLPSPSSWDLQPELAAPQGTP
GPLGVERRGSGKVINQVSLHQDGHLGGAGPPGHCLVADRTSEALPLCWQGGFQPESTPSLDAGLAELAPLQGQGLEKQVLGLQKGQQTGG
RGVLPQGKEPLAVPWEGSSGAMWGDDRGTPMAQSYDQNPSPRAAGERDDVCLSPGVWLSSEMDAVGLELPVQIEEVIESFQVEKCVTEYQ
EGCQGLGSRGNISLGPGETLVPGDTESSVIPCGGTVAAAALEKRNYCSLPGPLRANSPPLRSKENQEQSCETVGHPSDLWAEGCFPLLES
GDSTLGSSKETLPPTCQGNLLIMGTEDASSLPEASQEAGSRGNSFSPLLETIEPVNILDVKDDCGLQLRVSEDTCPLNVHSYDPQGEGRV
DPDLSKPKNLAPLQESQESYTTGTPKATSSHQGLGSTLPRRGTRNAIVPRETSVSKTHRSADRAKGKEKKKKEAEEEDEELSNFAYLLAS
KLSLSPREHPLSPHHASGGQGSQRASHLLPAGAKGPSKLPYPVAKSGKRALAGGPAPTEKTPHSGAQLGVPREKPLALGVVRPSQPRKRR

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>In-frame_ENST00000526115_ENST00000333756_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(transcript)=3816nt_BP=1030nt
CTTGCTCGCGGAGAGAGGAGCTAGGAGCCTCGGCCAATGGGAGCCGGCGTTGTTGGAGGCCACGGCGGCGCAGCCCCAAAGCGAGCGAAG
CTAGGGTCGCCGCCACTGCCGCAGGAGGCGTGAGGGAAAAGTGTTTTAGGCTTCCAGAGTAGAAATCTGATATTACTTCGTTTGATTCTT
CGACCACTATGGTGATAGGAAGTAGCTGATCTCTGCAGGAAACTGCTGTTACCTGGCCTCAGCTGAATTTTTGTGGGACCTCCTGAGGGG
ATAAAAACATTCAGATGGCAGATCACAGTTTTTCAGATGGGGTTCCTTCAGATTCCGTGGAAGCTGCTAAAAATGCAAGTAACACAGAAA
AGCTCACAGATCAGGTGATGCAGAATCCTCGAGTTCTGGCAGCTTTACAGGAGCGACTTGACAATGTCCCTCACACCCCTTCCAGCTACA
TCGAAACTTTACCTAAAGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCCAAGTTCTATG
AAGAGGTACATGACTTGGAAAGAAAGTATGCAGCGCTATACCAGCCTCTCTTTGACAAGAGAAGAGAATTTATCACCGGCGATGTTGAAC
CAACAGATGCGGAATCGGAATGGCACAGTGAAAATGAAGAGGAAGAGAAATTGGCTGGAGACATGAAAAGTAAAGTAGTCGTCACAGAAA
AAGCAGCGGCAACGGCTGAAGAGCCAGATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTCAGAAATGTGGACATGCTGAGTGAAT
TAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAATTTTCTGACCCTGGACAGCCTATGTCTTTTGTGT
TAGAGTTCCACTTTGAACCCAACGACTACTTTACCAACTCAGTCCTGACAAAAACCTACAAGATGAAATCAGAACCAGATAAGGCTGATC
CCTTTTCCTTTGAAGGTCCTGAGATTGTGGACTGTGACGGGTTCATGGAGTTTGAGGCTGAGGAGATGCAGATTCAGAACACACAGCTGA
TGAATGGGTCTCAGGGCCTGTCTCCTGCAACCCCTTTGAAACTTGATCCTCTAGGGCCCCTGGCCTCTGAGGTTTGCCAGCAGCCAGTGT
ACATTCCGAAGAAGGCAGCCTCCAAGACACGGGCCCCCCGCCGGCGTCAGCGTAAAGCCCAGAGACCTCCTGCTCCTGAGGCACCCAAGG
AGATCCCACCAGAAGCTGTGAAGGAGTATGTTGACATCATGGAATGGCTGGTGGGGACTCACTTGGCCACTGGGGAGTCAGATGGAAAAC
AAGAGGAAGAAGGGCAGCAGCAGGAGGAGGAAGGGATGTATCCAGATCCAGGTCTCCTGAGCTACATCAATGAGCTGTGTTCTCAGAAGG
TCTTTGTCTCCAAGGTGGAGGCTGTCATTCACCCTCAATTTCTGGCAGATCTGCTGTCCCCAGAAAAACAGAGAGATCCCTTGGCCTTAA
TTGAGGAGCTAGAGCAAGAAGAAGGACTCACTCTTGCCCAGCTGGTCCAGAAGCGACTCATGGCCTTGGAAGAGGAGGAAGATGCAGAGG
CGCCTCCAAGTTTCAGTGGCGCTCAGTTGGACTCAAGTCCTTCTGGTTCTGTTGAGGATGAAGATGGGGATGGGCGGCTTCGGCCCTCAC
CTGGGCTTCAGGGGGCTGGGGGCGCCGCTTGCCTTGGAAAGGTTTCTTCTTCAGGAAAACGGGCAAGAGAAGTGCATGGTGGGCAGGAGC
AAGCCCTAGATAGCCCCAGAGGGATGCACAGGGATGGGAACACTCTGCCATCCCCCAGCAGCTGGGACCTGCAGCCAGAACTTGCAGCTC
CACAGGGAACTCCGGGACCCTTGGGTGTGGAGAGGAGAGGGTCTGGGAAGGTTATAAACCAGGTATCTCTACATCAGGATGGCCATCTAG
GAGGCGCTGGGCCTCCTGGGCACTGCCTGGTGGCTGATAGGACTTCAGAGGCTCTGCCCCTTTGTTGGCAGGGAGGCTTCCAGCCTGAGA
GCACTCCCAGTTTGGATGCTGGACTTGCAGAGCTGGCTCCTCTGCAAGGACAAGGGTTAGAAAAGCAAGTCCTGGGATTGCAGAAAGGAC
AACAAACAGGGGGTCGTGGAGTGCTTCCTCAAGGGAAGGAGCCTTTAGCAGTGCCCTGGGAAGGCTCTTCAGGAGCCATGTGGGGAGATG
ACAGAGGTACCCCCATGGCTCAGAGTTATGATCAGAATCCTTCCCCTAGAGCAGCTGGGGAGAGGGACGATGTCTGTCTCAGCCCAGGAG
TTTGGCTGAGCAGTGAGATGGATGCTGTAGGCTTGGAGCTGCCTGTACAAATAGAGGAGGTCATAGAGAGCTTCCAAGTTGAGAAGTGTG
TAACTGAGTATCAGGAAGGCTGCCAGGGACTGGGCTCCAGGGGCAACATTTCCCTGGGTCCTGGAGAAACCCTAGTACCTGGGGATACGG
AGAGCAGTGTGATTCCCTGTGGAGGCACAGTTGCGGCAGCTGCCCTAGAAAAGAGAAACTATTGCAGCTTGCCAGGACCTTTGAGGGCCA
ACAGCCCACCCTTGAGGTCCAAAGAAAATCAAGAACAGAGCTGTGAAACCGTAGGGCATCCCAGTGATCTGTGGGCAGAAGGTTGCTTCC
CATTGCTAGAAAGTGGTGATTCCACACTGGGGTCTTCCAAAGAAACCCTTCCACCCACATGCCAAGGCAATCTCCTTATCATGGGGACTG
AGGATGCCTCCTCCTTGCCTGAAGCCAGTCAAGAGGCAGGGAGCAGAGGCAATTCCTTTTCTCCTCTGTTGGAAACCATAGAACCTGTCA
ACATACTAGATGTTAAAGATGACTGTGGCCTCCAACTAAGGGTCAGCGAGGACACCTGCCCACTGAATGTTCATTCTTATGACCCCCAAG
GAGAAGGCAGGGTGGATCCTGATCTGTCCAAGCCTAAAAACCTTGCTCCTTTACAAGAGAGTCAGGAGTCTTACACAACTGGGACTCCCA
AAGCAACATCTTCTCACCAGGGCCTTGGAAGCACTTTGCCTAGAAGGGGAACCAGGAATGCCATAGTTCCGAGAGAAACTTCTGTTAGTA
AAACACACAGGTCAGCAGACAGGGCCAAAGGAAAGGAGAAAAAGAAAAAGGAAGCAGAGGAAGAGGATGAGGAACTCTCCAACTTTGCTT
ACCTCTTGGCCTCTAAACTTAGCCTCTCACCAAGGGAGCATCCCCTCAGTCCTCACCATGCCTCAGGAGGTCAGGGCAGCCAGAGAGCAT
CCCACCTGCTCCCTGCTGGAGCAAAAGGCCCCAGCAAACTTCCATATCCTGTTGCCAAGTCTGGGAAGCGAGCTCTAGCTGGAGGTCCAG
CCCCTACTGAAAAGACACCCCACTCAGGAGCTCAACTTGGGGTCCCCAGGGAGAAACCCCTAGCTCTGGGAGTAGTTCGACCCTCACAGC
CTCGTAAAAGGCGGTGTGACAGTTTTGTCACGGGCAGAAGGAAGAAACGACGTCGTAGCCAGTAGGGAGCAGCGGGACCATCTGACCCCA
CTTGCCAGTCCCTAAAGGTGGGTGCCCCAGAGTAGATTCCACCCCTGCTGCCCACCAATGGAGAATCCCAATGTTGAATCTCATCCCAAT
GTTGTTTTGTTGTTCTGCAAAAGTGGCAAGCATGGAGAGAGAGGTCAGACTGGCTAGGCTGCAGGGGGAATTACCTTTGGAAGGAGCTAT

>In-frame_ENST00000526115_ENST00000333756_MF571888_NAP1L4_chr11_2980998_-_NUTM1_chr15_34645936_length(amino acids)=1096AA_start in transcript=284_stop in transcript=3574
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGFMEFEAEEMQIQNTQLMNGSQ
GLSPATPLKLDPLGPLASEVCQQPVYIPKKAASKTRAPRRRQRKAQRPPAPEAPKEIPPEAVKEYVDIMEWLVGTHLATGESDGKQEEEG
QQQEEEGMYPDPGLLSYINELCSQKVFVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQEEGLTLAQLVQKRLMALEEEEDAEAPPSF
SGAQLDSSPSGSVEDEDGDGRLRPSPGLQGAGGAACLGKVSSSGKRAREVHGGQEQALDSPRGMHRDGNTLPSPSSWDLQPELAAPQGTP
GPLGVERRGSGKVINQVSLHQDGHLGGAGPPGHCLVADRTSEALPLCWQGGFQPESTPSLDAGLAELAPLQGQGLEKQVLGLQKGQQTGG
RGVLPQGKEPLAVPWEGSSGAMWGDDRGTPMAQSYDQNPSPRAAGERDDVCLSPGVWLSSEMDAVGLELPVQIEEVIESFQVEKCVTEYQ
EGCQGLGSRGNISLGPGETLVPGDTESSVIPCGGTVAAAALEKRNYCSLPGPLRANSPPLRSKENQEQSCETVGHPSDLWAEGCFPLLES
GDSTLGSSKETLPPTCQGNLLIMGTEDASSLPEASQEAGSRGNSFSPLLETIEPVNILDVKDDCGLQLRVSEDTCPLNVHSYDPQGEGRV
DPDLSKPKNLAPLQESQESYTTGTPKATSSHQGLGSTLPRRGTRNAIVPRETSVSKTHRSADRAKGKEKKKKEAEEEDEELSNFAYLLAS
KLSLSPREHPLSPHHASGGQGSQRASHLLPAGAKGPSKLPYPVAKSGKRALAGGPAPTEKTPHSGAQLGVPREKPLALGVVRPSQPRKRR

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Fusion Gene PPI Analysis for NAP1L4-NUTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAP1L4-NUTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAP1L4-NUTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAP1L4C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNUTM1C1707291NUT midline carcinoma1ORPHANET