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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:NASP-NOP56 (FusionGDB2 ID:56958) |
Fusion Gene Summary for NASP-NOP56 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NASP-NOP56 | Fusion gene ID: 56958 | Hgene | Tgene | Gene symbol | NASP | NOP56 | Gene ID | 4678 | 10528 |
Gene name | nuclear autoantigenic sperm protein | NOP56 ribonucleoprotein | |
Synonyms | FLB7527|HMDRA1|PRO1999 | NOL5A|SCA36 | |
Cytomap | 1p34.1 | 20p13 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear autoantigenic sperm proteinNASP histone chaperonehistone H1-binding proteinnuclear autoantigenic sperm protein (histone-binding) | nucleolar protein 56NOP56 ribonucleoprotein homolognucleolar protein 5A (56kDa with KKE/D repeat) | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | O00567 | |
Ensembl transtripts involved in fusion gene | ENST00000402363, ENST00000537798, ENST00000350030, ENST00000372052, ENST00000351223, ENST00000530073, | ENST00000329276, ENST00000492135, | |
Fusion gene scores | * DoF score | 9 X 9 X 5=405 | 6 X 5 X 1=30 |
# samples | 9 | 6 | |
** MAII score | log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NASP [Title/Abstract] AND NOP56 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NASP(46072216)-NOP56(2637494), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NASP | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
Hgene | NASP | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
Fusion gene breakpoints across NASP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across NOP56 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | CN266780 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
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Fusion Gene ORF analysis for NASP-NOP56 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000402363 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
5CDS-3UTR | ENST00000402363 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
In-frame | ENST00000537798 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
5CDS-3UTR | ENST00000537798 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
In-frame | ENST00000350030 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
5CDS-3UTR | ENST00000350030 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
In-frame | ENST00000372052 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
5CDS-3UTR | ENST00000372052 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
In-frame | ENST00000351223 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
5CDS-3UTR | ENST00000351223 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
intron-3CDS | ENST00000530073 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
intron-3UTR | ENST00000530073 | ENST00000492135 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000402363 | NASP | chr1 | 46072216 | + | ENST00000329276 | NOP56 | chr20 | 2637494 | + | 1171 | 521 | 13 | 1071 | 352 |
ENST00000537798 | NASP | chr1 | 46072216 | + | ENST00000329276 | NOP56 | chr20 | 2637494 | + | 906 | 256 | 48 | 806 | 252 |
ENST00000350030 | NASP | chr1 | 46072216 | + | ENST00000329276 | NOP56 | chr20 | 2637494 | + | 1083 | 433 | 33 | 983 | 316 |
ENST00000372052 | NASP | chr1 | 46072216 | + | ENST00000329276 | NOP56 | chr20 | 2637494 | + | 999 | 349 | 30 | 899 | 289 |
ENST00000351223 | NASP | chr1 | 46072216 | + | ENST00000329276 | NOP56 | chr20 | 2637494 | + | 1078 | 428 | 28 | 978 | 316 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000402363 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + | 0.005631742 | 0.99436826 |
ENST00000537798 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + | 0.002754495 | 0.99724555 |
ENST00000350030 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + | 0.001859845 | 0.9981401 |
ENST00000372052 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + | 0.001908474 | 0.9980915 |
ENST00000351223 | ENST00000329276 | NASP | chr1 | 46072216 | + | NOP56 | chr20 | 2637494 | + | 0.001831198 | 0.9981688 |
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Fusion Genomic Features for NASP-NOP56 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NASP-NOP56 |
Go to FGviewer for the breakpoints of chr1:46072216-chr20:2637494 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | NOP56 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | NOP56 | chr1:46072216 | chr20:2637494 | ENST00000329276 | 0 | 12 | 438_589 | 0 | 595.0 | Compositional bias | Note=Lys-rich | |
Tgene | NOP56 | chr1:46072216 | chr20:2637494 | ENST00000329276 | 0 | 12 | 292_410 | 0 | 595.0 | Domain | Nop |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 136_164 | 0 | 789.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 460_487 | 0 | 789.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 597_665 | 0 | 789.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 753_778 | 0 | 789.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 136_164 | 0 | 450.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 460_487 | 0 | 450.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 597_665 | 0 | 450.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 753_778 | 0 | 450.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 136_164 | 0 | 791.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 460_487 | 0 | 791.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 597_665 | 0 | 791.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 753_778 | 0 | 791.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 136_164 | 0 | 725.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 460_487 | 0 | 725.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 597_665 | 0 | 725.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 753_778 | 0 | 725.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 111_658 | 0 | 789.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 111_658 | 0 | 450.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 111_658 | 0 | 791.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 111_658 | 0 | 725.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 716_722 | 0 | 789.0 | Motif | Nuclear localization signal |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 716_722 | 0 | 450.0 | Motif | Nuclear localization signal |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 716_722 | 0 | 791.0 | Motif | Nuclear localization signal |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 716_722 | 0 | 725.0 | Motif | Nuclear localization signal |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 116_127 | 0 | 789.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 211_244 | 0 | 789.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 469_512 | 0 | 789.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 116_127 | 0 | 450.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 211_244 | 0 | 450.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 469_512 | 0 | 450.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 116_127 | 0 | 791.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 211_244 | 0 | 791.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 469_512 | 0 | 791.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 116_127 | 0 | 725.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 211_244 | 0 | 725.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 469_512 | 0 | 725.0 | Region | Histone-binding |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 43_76 | 0 | 789.0 | Repeat | Note=TPR 1 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 542_575 | 0 | 789.0 | Repeat | Note=TPR 2 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000350030 | + | 1 | 15 | 584_617 | 0 | 789.0 | Repeat | Note=TPR 3 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 43_76 | 0 | 450.0 | Repeat | Note=TPR 1 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 542_575 | 0 | 450.0 | Repeat | Note=TPR 2 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000351223 | + | 1 | 14 | 584_617 | 0 | 450.0 | Repeat | Note=TPR 3 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 43_76 | 0 | 791.0 | Repeat | Note=TPR 1 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 542_575 | 0 | 791.0 | Repeat | Note=TPR 2 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000402363 | + | 1 | 16 | 584_617 | 0 | 791.0 | Repeat | Note=TPR 3 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 43_76 | 0 | 725.0 | Repeat | Note=TPR 1 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 542_575 | 0 | 725.0 | Repeat | Note=TPR 2 |
Hgene | NASP | chr1:46072216 | chr20:2637494 | ENST00000537798 | + | 1 | 13 | 584_617 | 0 | 725.0 | Repeat | Note=TPR 3 |
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Fusion Gene Sequence for NASP-NOP56 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000402363_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(transcript)=1171nt_BP=521nt AATCTGCCATTTTCTGTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCAC CTCAGGGGAACGATGGCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCT CCTTCTACATCTGCAGATAAAGTGGAGAGCAACCATTAATCTGCTTTCTGTCACTGAAGATGGGTTGCATTTTGTAGAATATTATCTAAA TAGAATCATACATCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGC TGTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTATGG GAAATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAATCT GGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTAAA GAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAAAA ACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAGAA AAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCTAC ACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCGGT CAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCAAA TGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTCACAAG >In-frame_ENST00000402363_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(amino acids)=352AA_start in transcript=13_stop in transcript=1071 MSLSESLASQIACFSRRLYSVRWFATSGERWPWSPQPLPPSPRSWFLPTKLKMFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIH LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMK EAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSF -------------------------------------------------------------- >In-frame_ENST00000537798_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(transcript)=906nt_BP=256nt AATCTGCCATTTTCTGTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCAC CTCAGGGGAACGATGGCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCT CCTTCTACATCTGCAGATAAAGTGGAGAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAG AATCTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGC TTAAAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGT GAAAAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCC AAGAAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAG TCTACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAG CCGGTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAAT GCAAATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTC >In-frame_ENST00000537798_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(amino acids)=252AA_start in transcript=48_stop in transcript=806 MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVERKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAA AEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDL -------------------------------------------------------------- >In-frame_ENST00000350030_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(transcript)=1083nt_BP=433nt GTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATG GCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCA GATAAAGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCA GCTGTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTAT GGGAAATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAAT CTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTA AAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAA AAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAG AAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCT ACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCG GTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCA AATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTCACA >In-frame_ENST00000350030_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(amino acids)=316AA_start in transcript=33_stop in transcript=983 MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL LGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALA LASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPE -------------------------------------------------------------- >In-frame_ENST00000372052_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(transcript)=999nt_BP=349nt CCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATGGCC ATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCAGAT AAAGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGCT GTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGA AAGAATCTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAA CGCTTAAAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATG AGTGAAAAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAA CCCAAGAAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAG AAGTCTACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAG GAGCCGGTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAG AATGCAAATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAA >In-frame_ENST00000372052_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(amino acids)=289AA_start in transcript=30_stop in transcript=899 MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL LKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQ KPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEA -------------------------------------------------------------- >In-frame_ENST00000351223_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(transcript)=1078nt_BP=428nt TGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATGGCCAT GGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCAGATAA AGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGCTGT CAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTATGGGAA ATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAATCTGGA TGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTAAAGAA GGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAAAAACC CAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAGAAAAA GAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCTACACC CAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCGGTCAG CAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCAAATGG >In-frame_ENST00000351223_ENST00000329276_CN266780_NASP_chr1_46072216_+_NOP56_chr20_2637494_length(amino acids)=316AA_start in transcript=28_stop in transcript=978 MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL LGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALA LASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NASP-NOP56 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NASP-NOP56 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NASP-NOP56 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NOP56 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Tgene | NOP56 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | NOP56 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | NOP56 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Tgene | NOP56 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |