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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOA6-TCFL5 (FusionGDB2 ID:57459)

Fusion Gene Summary for NCOA6-TCFL5

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA6-TCFL5
Fusion gene ID: 57459
HgeneTgene
Gene symbol

NCOA6

TCFL5

Gene ID

23054

10732

Gene namenuclear receptor coactivator 6transcription factor like 5
SynonymsAIB3|ASC2|NRC|PRIP|RAP250|TRBPCHA|E2BP-1|Figlb|SOSF1|bHLHe82
Cytomap

20q11.22

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 6NRC RAP250PPAR-interacting proteinactivating signal cointegrator-2amplified in breast cancer protein 3amplified in breast cancer-3 proteincancer-amplified transcriptional coactivator ASC-2nuclear receptor coactivator Rtranscription factor-like 5 proteinHPV-16 E2-binding protein 1cha transcription factorspermatogenesis- and oogenesis-specific bHLH-containing protein 1transcription factor-like 5 (basic helix-loop-helix)
Modification date2020031320200313
UniProtAcc

Q14686

.
Ensembl transtripts involved in fusion geneENST00000593786, ENST00000374796, 
ENST00000359003, 		ENST00000335351, 
ENST00000217162, 
Fusion gene scores* DoF score19 X 14 X 11=29267 X 8 X 5=280
# samples 257
** MAII scorelog2(25/2926*10)=-3.5489297694764
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOA6 [Title/Abstract] AND TCFL5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOA6(33324494)-TCFL5(61473449), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA6

GO:0006352

DNA-templated transcription, initiation

10567404

HgeneNCOA6

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneNCOA6

GO:0030099

myeloid cell differentiation

11302752

HgeneNCOA6

GO:0045944

positive regulation of transcription by RNA polymerase II

11443112

TgeneTCFL5

GO:0000122

negative regulation of transcription by RNA polymerase II

12923186

TgeneTCFL5

GO:0006355

regulation of transcription, DNA-templated

9763657


check buttonFusion gene breakpoints across NCOA6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TCFL5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4244-01ANCOA6chr20

33324494

-TCFL5chr20

61473449

-
ChimerDB4LUADTCGA-05-4244-01ANCOA6chr20

33324494

-TCFL5chr20

61473449

-
ChimerDB4LUADTCGA-05-4244-01ANCOA6chr20

33324494

-TCFL5chr20

61473449

-


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Fusion Gene ORF analysis for NCOA6-TCFL5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000593786ENST00000335351NCOA6chr20

33324494

-TCFL5chr20

61473449

-
intron-intronENST00000593786ENST00000217162NCOA6chr20

33324494

-TCFL5chr20

61473449

-
In-frameENST00000374796ENST00000335351NCOA6chr20

33324494

-TCFL5chr20

61473449

-
5CDS-intronENST00000374796ENST00000217162NCOA6chr20

33324494

-TCFL5chr20

61473449

-
In-frameENST00000359003ENST00000335351NCOA6chr20

33324494

-TCFL5chr20

61473449

-
5CDS-intronENST00000359003ENST00000217162NCOA6chr20

33324494

-TCFL5chr20

61473449

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374796NCOA6chr2033324494-ENST00000335351TCFL5chr2061473449-95168533254185401999
ENST00000359003NCOA6chr2033324494-ENST00000335351TCFL5chr2061473449-7286630331163101999

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374796ENST00000335351NCOA6chr2033324494-TCFL5chr2061473449-0.0104068070.98959315
ENST00000359003ENST00000335351NCOA6chr2033324494-TCFL5chr2061473449-0.0032752410.9967248

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Fusion Genomic Features for NCOA6-TCFL5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCOA6-TCFL5


check button Go to

FGviewer for the breakpoints of chr20:33324494-chr20:61473449

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA6

Q14686

.
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-1215227_10411987.33333333333332064.0Compositional biasNote=Gln-rich
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-1215372_3771987.33333333333332064.0Compositional biasNote=Poly-Pro
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-1215913_9181987.33333333333332064.0Compositional biasNote=Poly-Lys
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-1316227_10411987.33333333333332064.0Compositional biasNote=Gln-rich
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-1316372_3771987.33333333333332064.0Compositional biasNote=Poly-Pro
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-1316913_9181987.33333333333332064.0Compositional biasNote=Poly-Lys
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-12151491_14951987.33333333333332064.0MotifNote=LXXLL motif 2
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-1215887_8911987.33333333333332064.0MotifNote=LXXLL motif 1
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-13161491_14951987.33333333333332064.0MotifNote=LXXLL motif 2
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-1316887_8911987.33333333333332064.0MotifNote=LXXLL motif 1
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-12151_10571987.33333333333332064.0RegionNote=CREBBP-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-12151_13101987.33333333333332064.0RegionNote=NCOA1-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-12151_9281987.33333333333332064.0RegionNote=TBP/GTF2A-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-1215773_9271987.33333333333332064.0RegionNote=NCOA6IP-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-13161_10571987.33333333333332064.0RegionNote=CREBBP-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-13161_13101987.33333333333332064.0RegionNote=NCOA1-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-13161_9281987.33333333333332064.0RegionNote=TBP/GTF2A-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-1316773_9271987.33333333333332064.0RegionNote=NCOA6IP-binding region
TgeneTCFL5chr20:33324494chr20:61473449ENST0000033535146481_500460.0501.0RegionNote=R1 epitope (recognized by Chagas's antibodies)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA6chr20:33324494chr20:61473449ENST00000359003-12151641_20631987.33333333333332064.0RegionNote=EP300/CRSP3-binding region
HgeneNCOA6chr20:33324494chr20:61473449ENST00000374796-13161641_20631987.33333333333332064.0RegionNote=EP300/CRSP3-binding region
TgeneTCFL5chr20:33324494chr20:61473449ENST000003353514667_182460.0501.0Compositional biasNote=Ala-rich
TgeneTCFL5chr20:33324494chr20:61473449ENST0000033535146400_450460.0501.0DomainbHLH
TgeneTCFL5chr20:33324494chr20:61473449ENST0000033535146347_356460.0501.0RegionNote=R3 epitope (recognized by Chagas's antibodies)


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Fusion Gene Sequence for NCOA6-TCFL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000374796_ENST00000335351_TCGA-05-4244-01A_NCOA6_chr20_33324494_-_TCFL5_chr20_61473449_length(transcript)=9516nt_BP=8533nt
CTCCAGCCCAGGCAACAGAGCGTGACTCCGTCTCAAAAAAAAAAAAAAAAGTGAAAGGAAAATGAGGGGAGAATTCTCATTGATAATAAG
GGCGAAAAGGTTTTTTTGGCAGAGTAATAGAGTTTTGGAAACCATTGCAAAGCTGTCAAGTGTGGTGTAGTTTTTGGTTAAGGAAATCAG
AGGTGTCAGCAGACATAAAAGACAGGGGAAAACATGGGAAGTGTCCTACCTATAGTGTAGAAAAAGCACAACTATCTATGTCAGAGGTCG
ACAGACTGTGGTCCATAGGTCAAATCTGGCCCACGATCTGTTTTTGTAAATAACGTTTTATTGGAACATAGCCACACTCATTTATTTATA
TATTGTCCATATCTTCTTTTGTGGTACCAATAGCAGAGTTGAGTAGTCGTGACAGAGATGTGTTGTGTCAGCTCACAAAGCTGGAAATAC
TCTTTACAAAAACATTTGCCAACCCCTGATCTATGTGTTTGAGTGTTGGATGTTCAACCTCTAATTTGCCATCCAATGTCTATATGATGA
TAGAGAATGAATAAACGTCTTGGCTCTGCCCTTTGGGCTGGATTACCCATGCTCTGTGTACCTGCAGCATAACACAGACCCCTGAATATT
TATATCAGTCAGTGATGGCAAGGTCTATTGTTCTGGAGTGTACTGTGTGGTAACTGTGGTAGTGCCAGCTTTACACGGATTAGATAATGC
TCGGGCTTGTTTTGCCATTTTTTTTATTGGGTTGTCTTTTACAAAAGATTTATTTATATATTCTGATTATTAATCCTTTGTTGTTGGTAG
ATATTACAGATGTCATTTCCCAGTTTCTTGCTTATTTTAATTTTTTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTCGCCCAGGCTG
GAGTGCAGTCGTGCCATCTCAGCTCATTGTAACCTCCGTCTCCCAGGTTCAAGTGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGACT
ACAGGCATGTGCCACCACACCTGGCTGATTTTTGTGTTTTTAGTAGGGATGGGGTTTCATCATGTTGGCCAGGCTGGTCTCAAACTCCTG
ACCTCAAGTGATCCACCCGTCTTGGCCTCCTAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCCTGTTGCTTATTTTAAAACA
TCTGTTTTAAGGTGTCATTTGTTAAAAAGTTCTGAATTTTAGTATCAACTTTATCAATCTTTTCCTTTAAGATTTGCAGTTATTCTTTGT
TTTGAGGCAGGGTCTCGCTCTGTCACCGAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAGCCTCAACCTCCTGGGCTCAAGCAA
CCCTCCCACCTCCCATGCCAGTTGAGACCACAGGCATGCGCCACCATGCCCTGCTACTTTTTGCATTTTTTGTAGAGGCGGGGTTTCGCC
ATGTTGCCCAGGCTAGTCTGGAACTCCTGAGCTCAAGCAGTCCACAAAGTGCTGGGATTACAGGTGTGAGCTACTGTGCCCAGCCTGCAA
TTATTCTTTATATTCTGGAATACCTACTGTTGTTTTCAATGGTTAGATCTTTAATGTATCTGGAATGGATTCTTATGTGTAGTGTAAGGT
CGGGTCCAGTTTCATTTTTTTTCCCTATGTATAACCAGTGATCCCAGCATCATTTATTGAATGGGGCTTGCTTTCAAATTGTGAGCTCTT
TTTGGTGGAGTCTGTCTCAGGTCCTTATTAAGCACTGCTGCTTGCTGATTGTGTGACCTTGGACAAATAAAACCTCATTGCGCCTCAGTC
TTTAAGGATAATAGTAATCTCATAGGGTTTTGTGAGGATTAAATGAGTCAATATACATAACGTGTAAAACAGTGCTTGGCACCTAGAACA
TGCTCAATAAATATTAGCTGTACTTTAGCACTACTGTTCATTTCTGATTCCTCAGCACCTGGTACAGAGCAGGGGCTCATTTTGCTCAAT
TAAATTGCCAAATTAATTTGGTTTTCAGGTCAATCAGAATGGTGAGAGTTGGGCTGAGTGTTGCAGGAGATGCTTCCAAGGAGCTACTTA
GTTTTAGGGGCTGCCTTAGATTATCTGCTAGGATAGAACTCTTCTCACGCCATCACTTTTGCAGAGAACTTCTGTAGCAGAGGTTGCAAA
CTGGCAACCTGTGGTTGGATTTGACCTGTATAAGTATTTTGTTTGGTTTACACAATATTTTTAATGTCTTAAAAATGTACACAGACCTCT
GAGTTTCTGACTTAACCTTGAAAAATTGGAAGATCTGTCAACAGCAAGCCCATATTCATTTATAGCGGTAACCAGCTGAAACTTTTAGGT
CCTGGGAGGAATGGAGAGGGGTCCCACTGACTAACTTTTCTGAGAGTGGTCAGAGAGTTCTTAAGCAGAATTTTGATTTGGCTGCTGGGC
TGCTACCTTGAAATCCAAGCCCTAAAAATGCCAGCTTCTTTGGACTTAGAAGATGACCTGGATAAATGATAAAAATTAAGAAAGAGATTT
TGAAGTTTTCTTATTGTCCTCTTGGCATATGCTTCTGGAATAATATTCACCATGGTTTTGGATGACCTTCCAAACTTAGAAGACATCTAT
ACTTCCTTGTGTTCATCAACAATGGAAGACTCAGAGATGGATTTTGACTCTGGACTAGAAGATGATGACACAAAAAGTGATAGTATTTTG
GAGGATTCCACAATTTTTGTGGCCTTCAAAGGAAATATAGATGATAAAGACTTCAAATGGAAATTAGATGCAATATTGAAAAACGTGCCC
AATTTGTTACACATGGAGTCCAGCAAGCTAAAAGTACAGAAGGTGGAGCCCTGGAACAGCGTGCGTGTGACATTCAACATCCCCCGGGAA
GCAGCGGAGCGGCTACGGATCCTTGCTCAGAGCAACAACCAGCAGCTTCGGGATTTAGGGATTCTCTCCGTTCAGATTGAAGGGGAAGGT
GCTATTAACCTGGCTTTGGCTCAGAACCGAAGCCAAGATGTGAGAATGAATGGACCCATGGGAGCTGGAAATTCAGTTAGGATGGAGGCG
GGATTTCCTATGGCAAGTGGTCCAGGAATAATAAGGATGAACAACCCTGCCACTGTTATGATACCCCCGGGTGGAAATGTGTCATCTTCC
ATGATGGCACCAGGCCCCAATCCAGAGCTGCAGCCCAGGACTCCTCGCCCTGCTTCTCAGTCAGATGCAATGGATCCACTCCTCTCTGGG
CTCCATATACAGCAGCAAAGTCATCCCTCAGGATCTTTAGCTCCCCCACATCACCCAATGCAGCCTGTCTCTGTGAACAGACAAATGAAC
CCAGCTAATTTTCCCCAGCTGCAGCAGCAGCAGCAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAACAACAGCAACAGCAGCAA
CAACAGTTGCAGGCAAGACCCCCACAGCAACATCAGCAGCAACAGCCACAGGGAATTCGACCCCAGTTTACTGCCCCAACTCAGGTGCCT
GTTCCTCCAGGCTGGAACCAGCTGCCTTCTGGAGCCCTTCAACCTCCTCCAGCCCAGGGTTCTCTGGGCACAATGACTGCAAACCAAGGG
TGGAAGAAGGCTCCCTTGCCCGGCCCAATGCAACAGCAACTCCAGGCAAGACCATCCTTAGCCACGGTACAGACGCCTTCCCACCCTCCC
CCTCCATATCCCTTTGGCAGCCAGCAAGCCTCACAAGCCCACACAAACTTTCCTCAGATGAGCAACCCAGGCCAGTTCACAGCTCCTCAG
ATGAAGAGTTTGCAGGGAGGGCCCTCTAGGGTCCCAACTCCCTTGCAGCAGCCCCACCTCACCAACAAGTCTCCTGCCTCCTCACCCTCC
TCCTTCCAGCAGGGATCCCCTGCATCCTCCCCAACGGTTAACCAAACTCAGCAGCAGATGGGACCAAGGCCACCTCAAAATAACCCACTT
CCCCAGGGATTTCAGCAGCCTGTCAGCTCTCCGGGTCGGAATCCTATGGTTCAACAGGGAAATGTGCCACCTAACTTCATGGTGATGCAG
CAGCAACCACCAAACCAGGGGCCACAGAGTTTACATCCAGGCCTAGGAGGAATGCCTAAACGCCTCCCACCTGGCTTCTCAGCAGGACAG
GCCAATCCGAACTTTATGCAAGGTCAGGTGCCTTCGACCACAGCAACCACCCCTGGGAATTCAGGAGCCCCTCAGCTGCAAGCAAATCAA
AATGTCCAGCATGCAGGTGGTCAAGGAGCTGGTCCTCCTCAAAACCAGATGCAGGTGTCCCACGGGCCGCCAAATATGATGCAGCCCAGC
CTCATGGGAATTCATGGCAACATGAACAATCAGCAGGCTGGTACTTCTGGGGTTCCTCAAGTGAACCTCAGCAACATGCAAGGCCAGCCC
CAGCAGGGCCCACCATCTCAGCTGATGGGCATGCACCAGCAAATCGTGCCCTCCCAGGGCCAGATGGTCCAGCAACAAGGAACCTTGAAC
CCTCAGAACCCTATGATCCTTTCAAGGGCCCAGCTTATGCCACAGGGCCAGATGATGGTGAACCCCCCGAGCCAAAATCTTGGGCCCTCG
CCCCAAAGGATGACCCCACCCAAGCAGATGCTTTCCCAGCAGGGCCCACAAATGATGGCGCCACATAACCAGATGATGGGGCCTCAGGGG
CAGGTTTTGCTCCAACAGAACCCAATGATAGAGCAGATTATGACCAATCAAATGCAGGGGAATAAGCAGCAGTTTAACACTCAGAACCAG
TCCAATGTCATGCCGGGACCAGCCCAGATAATGAGGGGACCAACTCCAAACATGCAAGGAAATATGGTGCAGTTTACGGGACAGATGTCA
GGACAGATGCTGCCCCAGCAAGGGCCTGTGAACAACAGTCCATCTCAGGTTATGGGCATTCAGGGACAGGTCCTGCGGCCACCAGGGCCC
AGCCCACACATGGCCCAGCAGCATGGTGATCCTGCTACTACAGCAAATAACGATGTCAGTTTATCTCAGATGATGCCTGATGTTAGCATT
CAACAAACCAACATGGTCCCCCCTCATGTGCAGGCCATGCAGGGAAACAGTGCCTCGGGAAACCACTTCTCAGGCCATGGGATGTCTTTC
AATGCACCTTTCAGTGGAGCTCCCAATGGAAATCAGATGTCCTGTGGTCAAAATCCAGGCTTCCCAGTCAATAAGGATGTCACGCTAACG
AGCCCATTGTTGGTCAACTTATTGCAGAGTGACATATCTGCAGGCCATTTTGGGGTAAACAATAAGCAAAATAATACCAACGCAAATAAA
CCGAAGAAGAAGAAACCCCCTCGGAAGAAGAAAAATAGTCAGCAAGATCTAAACACCCCAGATACTCGCCCAGCTGGTCTGGAAGAGGCT
GATCAGCCACCGTTGCCTGGAGAACAAGGAATTAACTTGGATAACTCAGGCCCTAAACTGCCAGAATTTTCAAACCGGCCACCAGGTTAT
CCTTCTCAACCAGTTGAACAGAGGCCACTTCAGCAGATGCCTCCTCAACTCATGCAGCATGTGGCACCCCCACCACAGCCACCACAGCAG
CAGCCACAGCCACAACTGCCTCAGCAGCAGCAGCCACCACCTCCCAGTCAGCCACAGTCTCAGCAGCAGCAGCAGCAGCAGCAACAAATG
ATGATGATGCTCATGATGCAGCAGGATCCCAAATCAGTTAGGCTTCCAGTCTCTCAAAATGTCCATCCTCCAAGGGGCCCCCTGAACCCC
GACTCCCAGAGAATGCCCATGCAACAGAGTGGCAGTGTGCCTGTCATGGTCAGTCTGCAAGGACCTGCCTCCGTGCCACCATCACCTGAT
AAACAAAGAATGCCAATGCCTGTGAATACTCCCTTGGGAAGCAATTCAAGGAAAATGGTCTATCAGGAGAGCCCGCAGAATCCTTCCAGC
TCGCCACTGGCGGAGATGGCCTCACTCCCTGAAGCAAGTGGCAGTGAAGCACCATCTGTCCCAGGAGGCCCAAACAACATGCCTTCACAT
GTAGTACTTCCCCAGAATCAGTTAATGATGACAGGGCCAAAACCTGGACCATCGCCCCTTTCAGCAACTCAAGGTGCAACTCCCCAGCAA
CCCCCTGTAAATTCCCTGCCCAGCTCTCACGGCCACCACTTCCCAAATGTGGCTGCGCCAACCCAGACATCTAGGCCCAAAACACCAAAC
AGAGCCAGCCCCAGACCCTATTATCCTCAGACACCCAACAACCGCCCTCCCAGCACAGAACCTTCAGAAATCAGTCTGTCACCAGAAAGA
CTCAATGCCTCCATAGCAGGACTCTTCCCTCCACAGATTAATATTCCTTTACCTCCTAGGCCAAATTTAAACAGGGGCTTTGATCAACAA
GGCCTAAATCCAACAACTTTGAAGGCCATCGGGCAAGCACCTTCAAATCTTACCATGAATCCTTCCAATTTTGCTACCCCACAAACTCAC
AAATTAGATTCTGTGGTAGTGAATTCTGGAAAGCAGTCTAATTCTGGAGCAACAAAACGGGCAAGTCCAAGCAACAGTCGCAGGTCTAGT
CCTGGGTCCAGTAGGAAAACCACTCCAAGCCCTGGGAGGCAAAATTCAAAAGCCCCTAAACTTACTCTGGCCTCTCAGACAAATGCAGCC
CTATTGCAGAATGTGGAGTTGCCGAGAAATGTATTGGTCAGTCCCACTCCTCTGGCCAATCCCCCTGTACCTGGGAGCTTTCCTAACAAC
AGTGGGCTGAATCCTCAGAATTCTACTGTGTCTGTGGCTGCAGTTGGGGGTGTTGTTGAGGATAACAAGGAGAGCTTGAATGTGCCTCAG
GACAGTGATTGCCAGAATTCCCAGAGTAGGAAGGAACAGGTAAACATTGAACTAAAAGCAGTCCCTGCCCAAGAAGTTAAAATGGTTGTC
CCTGAAGATCAGTCCAAAAAGGATGGGCAGCCTTCGGATCCTAACAAACTTCCCAGTGTCGAAGAGAACAAAAATTTGGTGTCTCCTGCT
ATGAGGGAAGCACCAACATCGTTAAGTCAACTTCTTGACAACTCTGGAGCTCCCAATGTGACAATTAAACCCCCTGGGCTTACAGATCTG
GAAGTAACACCTCCAGTAGTTTCTGGGGAGGACCTCAAAAAAGCATCTGTCATTCCCACACTGCAGGATCTGTCTTCTTCTAAAGAACCT
TCTAATTCCCTAAACTTACCTCACAGTAATGAGCTGTGTTCATCCCTTGTGCATCCCGAATTGAGTGAGGTCAGTTCTAACGTTGCACCA
AGCATCCCTCCAGTAATGTCAAGACCTGTTAGCTCTTCCTCCATTTCCACTCCCTTGCCCCCAAATCAAATAACTGTATTTGTCACTTCC
AATCCCATCACAACTTCAGCTAACACATCAGCAGCTTTGCCAACTCACTTGCAGTCTGCATTGATGTCAACAGTTGTCACAATGCCCAAT
GCGGGTAGCAAGGTTATGGTTTCTGAGGGACAGTCAGCTGCTCAGTCTAATGCCCGGCCTCAGTTCATTACACCTGTCTTTATCAATTCA
TCCTCAATAATTCAGGTTATGAAAGGATCACAGCCAAGCACAATTCCTGCAGCCCCACTGACAACCAACTCTGGCCTGATGCCTCCCTCT
GTTGCAGTTGTTGGCCCTTTACACATACCTCAGAACATAAAATTTTCTTCTGCTCCTGTACCGCCTAATGCCCTCTCCAGTAGTCCTGCT
CCAAACATCCAGACAGGTCGACCTTTGGTCCTTAGCTCACGAGCCACCCCTGTTCAGCTTCCTTCCCCTCCTTGTACGTCTTCTCCAGTT
GTCCCTTCTCATCCCCCTGTGCAGCAAGTGAAAGAATTGAATCCAGATGAGGCTAGCCCTCAGGTGAACACCTCAGCAGATCAGAACACT
CTTCCCTCTTCACAGTCAACCACAATGGTTTCTCCCCTTTTGACCAATAGTCCAGGGTCCTCTGGCAACCGGCGAAGCCCAGTCTCGTCT
AGTAAGGGCAAAGGAAAAGTGGACAAAATTGGCCAAATTTTGTTGACCAAGGCATGTAAGAAAGTTACAGGCTCTCTTGAGAAAGGGGAA
GAACAATATGGTGCAGATGGAGAGACTGAAGGCCAAGGGCTAGACACCACAGCTCCGGGGCTCATGGGAACAGAGCAGTTATCCACAGAG
CTGGACAGTAAAACCCCAACGCCCCCAGCACCCACTCTGCTAAAAATGACCTCTAGCCCTGTGGGCCCGGGCACTGCCTCAGCAGGACCC
AGCTTACCTGGCGGTGCTCTCCCCACCAGTGTACGCTCGATAGTAACCACTCTGGTACCCTCCGAGCTCATCTCCGCCGTACCGACCACA
AAAAGCAATCATGGTGGCATAGCATCTGAGTCACTTGCGGGTGGCCTAGTGGAGGAGAAGGTGGGATCCCATCCAGAACTTCTACCCAGC
ATAGCCCCGTCGCAGAATTTAGTCTCAAAGGAAACTTCAACCACAGCACTGCAGGCCTCTGTTGCCAGACCAGGAATTTGAGAGCGTATT
TTGCGGTAAAACTGGCCGAAGGCTAAAGCTGACCAGACCGGACTCCTTGGTGACCTGTCCTGCACAGGGGAGTTTACAGAGCAGCCCCTC
GATGGAGATCAAGTGATCGGACTGAACAGGAATCCTCGGGGGGTGAACAGCCATTCCTTCGTGACCTGTGCACGCCTTCTGCAACCCTGG
AGCTCTGCTCGGCTAGTCTGACTCGAAAAGGGCGTGACTCAAGCTGACGGGACTCCAGTAGGGACTTTGAGAGCACATTTTGTAAAAATA
TTTATCTAGACGCAAATGCTTATCCATGAATGTCCTCTTAGACCATTTGGGGATGAAGCCATCTTAATAATTAGTAATAATTAATTAGTA
ATAATTAGTAAGCATTTTCTCAATGCTCTGATTCCATCATGTTTTCTTAACATGATAACTTAAAAAATTGACATCCTTTGTACTTTCTTT
AATCTTAAAAAGTACACGGCTTTTTACTTATTTACCTTTTAAATATGCCCCTTTAGCAATTGGAACAAGTTAAATTGTTAACTAAAAACA
GTTTGGAAATTTTATTTCATTCGTTATATCACACCCCCTTGTCATGACTCTGAGTCACGTGCTGCTGTATTGCAACGTGCAGGACCATTT
TAAACCTGTGTGCTAAAAATTTTCCAGATACTTGCTTTAAAGCTACTTTTGTCCACAAATGAAATACTGTCACAGTAGACGCTTAAATGC
CACGTTTTCATACCAAGAGTCATTCATTACTTCATGTGTCACAAACTGTGGTGTTTGGAATTGGGTTTTTCAATGAGTGGCTTTACTTAT
CAATCACAACAGGTAATAGCAATAGACGTTAGTGCAATACAAAGTCACCCTCAATAAATACTGTTAATTGGAGATGTGAGTTTGTACACA

>In-frame_ENST00000374796_ENST00000335351_TCGA-05-4244-01A_NCOA6_chr20_33324494_-_TCFL5_chr20_61473449_length(amino acids)=1999AA_start in transcript=2541_stop in transcript=8540
MAYASGIIFTMVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMES
SKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASG
PGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQL
QQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLP
GPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSP
ASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQ
GQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQ
LMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQN
PMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQ
HGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNL
LQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPSQPVEQ
RPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPM
QQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGGPNNMPSHVVLPQNQ
LMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAG
LFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRRSSPGSSRKT
TPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNS
QSRKEQVNIELKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVV
SGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLVHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSA
NTSAALPTHLQSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPAAPLTTNSGLMPPSVAVVGPL
HIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQST
TMVSPLLTNSPGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTTAPGLMGTEQLSTELDSKTPT
PPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNL

--------------------------------------------------------------
>In-frame_ENST00000359003_ENST00000335351_TCGA-05-4244-01A_NCOA6_chr20_33324494_-_TCFL5_chr20_61473449_length(transcript)=7286nt_BP=6303nt
CCCCCTCCCCGCCGGCTCCGTGAGGCCCTGCCGGGTCGGGCTGCGGGCGGCCGGGCGCGGGCGGCGGGACAGACGGGCGCACGCGAGGAC
TGACGGACGGACGCACCGAGGGCGGCGGGCACGCACGGCCCGGGCCGGCGCTCCAAGGCCCGCCCGGGAGGGCCGGGGCCGCGCTCAGAA
TTTTGATTTGGCTGCTGGGCTGCTACCTTGAAATCCAAGCCCTAAAAATGCCAGCTTCTTTGGACTTAGAAGATGACCTGGATAAATGAT
AAAAATTAAGAAAGAGATTTTGAAGTTTTCTTATTGTCCTCTTGGCATATGCTTCTGGAATAATATTCACCATGGTTTTGGATGACCTTC
CAAACTTAGAAGACATCTATACTTCCTTGTGTTCATCAACAATGGAAGACTCAGAGATGGATTTTGACTCTGGACTAGAAGATGATGACA
CAAAAAGTGATAGTATTTTGGAGGATTCCACAATTTTTGTGGCCTTCAAAGGAAATATAGATGATAAAGACTTCAAATGGAAATTAGATG
CAATATTGAAAAACGTGCCCAATTTGTTACACATGGAGTCCAGCAAGCTAAAAGTACAGAAGGTGGAGCCCTGGAACAGCGTGCGTGTGA
CATTCAACATCCCCCGGGAAGCAGCGGAGCGGCTACGGATCCTTGCTCAGAGCAACAACCAGCAGCTTCGGGATTTAGGGATTCTCTCCG
TTCAGATTGAAGGGGAAGGTGCTATTAACCTGGCTTTGGCTCAGAACCGAAGCCAAGATGTGAGAATGAATGGACCCATGGGAGCTGGAA
ATTCAGTTAGGATGGAGGCGGGATTTCCTATGGCAAGTGGTCCAGGAATAATAAGGATGAACAACCCTGCCACTGTTATGATACCCCCGG
GTGGAAATGTGTCATCTTCCATGATGGCACCAGGCCCCAATCCAGAGCTGCAGCCCAGGACTCCTCGCCCTGCTTCTCAGTCAGATGCAA
TGGATCCACTCCTCTCTGGGCTCCATATACAGCAGCAAAGTCATCCCTCAGGATCTTTAGCTCCCCCACATCACCCAATGCAGCCTGTCT
CTGTGAACAGACAAATGAACCCAGCTAATTTTCCCCAGCTGCAGCAGCAGCAGCAACAACAACAACAGCAGCAGCAGCAGCAGCAGCAGC
AACAACAGCAACAGCAGCAACAACAGTTGCAGGCAAGACCCCCACAGCAACATCAGCAGCAACAGCCACAGGGAATTCGACCCCAGTTTA
CTGCCCCAACTCAGGTGCCTGTTCCTCCAGGCTGGAACCAGCTGCCTTCTGGAGCCCTTCAACCTCCTCCAGCCCAGGGTTCTCTGGGCA
CAATGACTGCAAACCAAGGGTGGAAGAAGGCTCCCTTGCCCGGCCCAATGCAACAGCAACTCCAGGCAAGACCATCCTTAGCCACGGTAC
AGACGCCTTCCCACCCTCCCCCTCCATATCCCTTTGGCAGCCAGCAAGCCTCACAAGCCCACACAAACTTTCCTCAGATGAGCAACCCAG
GCCAGTTCACAGCTCCTCAGATGAAGAGTTTGCAGGGAGGGCCCTCTAGGGTCCCAACTCCCTTGCAGCAGCCCCACCTCACCAACAAGT
CTCCTGCCTCCTCACCCTCCTCCTTCCAGCAGGGATCCCCTGCATCCTCCCCAACGGTTAACCAAACTCAGCAGCAGATGGGACCAAGGC
CACCTCAAAATAACCCACTTCCCCAGGGATTTCAGCAGCCTGTCAGCTCTCCGGGTCGGAATCCTATGGTTCAACAGGGAAATGTGCCAC
CTAACTTCATGGTGATGCAGCAGCAACCACCAAACCAGGGGCCACAGAGTTTACATCCAGGCCTAGGAGGAATGCCTAAACGCCTCCCAC
CTGGCTTCTCAGCAGGACAGGCCAATCCGAACTTTATGCAAGGTCAGGTGCCTTCGACCACAGCAACCACCCCTGGGAATTCAGGAGCCC
CTCAGCTGCAAGCAAATCAAAATGTCCAGCATGCAGGTGGTCAAGGAGCTGGTCCTCCTCAAAACCAGATGCAGGTGTCCCACGGGCCGC
CAAATATGATGCAGCCCAGCCTCATGGGAATTCATGGCAACATGAACAATCAGCAGGCTGGTACTTCTGGGGTTCCTCAAGTGAACCTCA
GCAACATGCAAGGCCAGCCCCAGCAGGGCCCACCATCTCAGCTGATGGGCATGCACCAGCAAATCGTGCCCTCCCAGGGCCAGATGGTCC
AGCAACAAGGAACCTTGAACCCTCAGAACCCTATGATCCTTTCAAGGGCCCAGCTTATGCCACAGGGCCAGATGATGGTGAACCCCCCGA
GCCAAAATCTTGGGCCCTCGCCCCAAAGGATGACCCCACCCAAGCAGATGCTTTCCCAGCAGGGCCCACAAATGATGGCGCCACATAACC
AGATGATGGGGCCTCAGGGGCAGGTTTTGCTCCAACAGAACCCAATGATAGAGCAGATTATGACCAATCAAATGCAGGGGAATAAGCAGC
AGTTTAACACTCAGAACCAGTCCAATGTCATGCCGGGACCAGCCCAGATAATGAGGGGACCAACTCCAAACATGCAAGGAAATATGGTGC
AGTTTACGGGACAGATGTCAGGACAGATGCTGCCCCAGCAAGGGCCTGTGAACAACAGTCCATCTCAGGTTATGGGCATTCAGGGACAGG
TCCTGCGGCCACCAGGGCCCAGCCCACACATGGCCCAGCAGCATGGTGATCCTGCTACTACAGCAAATAACGATGTCAGTTTATCTCAGA
TGATGCCTGATGTTAGCATTCAACAAACCAACATGGTCCCCCCTCATGTGCAGGCCATGCAGGGAAACAGTGCCTCGGGAAACCACTTCT
CAGGCCATGGGATGTCTTTCAATGCACCTTTCAGTGGAGCTCCCAATGGAAATCAGATGTCCTGTGGTCAAAATCCAGGCTTCCCAGTCA
ATAAGGATGTCACGCTAACGAGCCCATTGTTGGTCAACTTATTGCAGAGTGACATATCTGCAGGCCATTTTGGGGTAAACAATAAGCAAA
ATAATACCAACGCAAATAAACCGAAGAAGAAGAAACCCCCTCGGAAGAAGAAAAATAGTCAGCAAGATCTAAACACCCCAGATACTCGCC
CAGCTGGTCTGGAAGAGGCTGATCAGCCACCGTTGCCTGGAGAACAAGGAATTAACTTGGATAACTCAGGCCCTAAACTGCCAGAATTTT
CAAACCGGCCACCAGGTTATCCTTCTCAACCAGTTGAACAGAGGCCACTTCAGCAGATGCCTCCTCAACTCATGCAGCATGTGGCACCCC
CACCACAGCCACCACAGCAGCAGCCACAGCCACAACTGCCTCAGCAGCAGCAGCCACCACCTCCCAGTCAGCCACAGTCTCAGCAGCAGC
AGCAGCAGCAGCAACAAATGATGATGATGCTCATGATGCAGCAGGATCCCAAATCAGTTAGGCTTCCAGTCTCTCAAAATGTCCATCCTC
CAAGGGGCCCCCTGAACCCCGACTCCCAGAGAATGCCCATGCAACAGAGTGGCAGTGTGCCTGTCATGGTCAGTCTGCAAGGACCTGCCT
CCGTGCCACCATCACCTGATAAACAAAGAATGCCAATGCCTGTGAATACTCCCTTGGGAAGCAATTCAAGGAAAATGGTCTATCAGGAGA
GCCCGCAGAATCCTTCCAGCTCGCCACTGGCGGAGATGGCCTCACTCCCTGAAGCAAGTGGCAGTGAAGCACCATCTGTCCCAGGAGGCC
CAAACAACATGCCTTCACATGTAGTACTTCCCCAGAATCAGTTAATGATGACAGGGCCAAAACCTGGACCATCGCCCCTTTCAGCAACTC
AAGGTGCAACTCCCCAGCAACCCCCTGTAAATTCCCTGCCCAGCTCTCACGGCCACCACTTCCCAAATGTGGCTGCGCCAACCCAGACAT
CTAGGCCCAAAACACCAAACAGAGCCAGCCCCAGACCCTATTATCCTCAGACACCCAACAACCGCCCTCCCAGCACAGAACCTTCAGAAA
TCAGTCTGTCACCAGAAAGACTCAATGCCTCCATAGCAGGACTCTTCCCTCCACAGATTAATATTCCTTTACCTCCTAGGCCAAATTTAA
ACAGGGGCTTTGATCAACAAGGCCTAAATCCAACAACTTTGAAGGCCATCGGGCAAGCACCTTCAAATCTTACCATGAATCCTTCCAATT
TTGCTACCCCACAAACTCACAAATTAGATTCTGTGGTAGTGAATTCTGGAAAGCAGTCTAATTCTGGAGCAACAAAACGGGCAAGTCCAA
GCAACAGTCGCAGGTCTAGTCCTGGGTCCAGTAGGAAAACCACTCCAAGCCCTGGGAGGCAAAATTCAAAAGCCCCTAAACTTACTCTGG
CCTCTCAGACAAATGCAGCCCTATTGCAGAATGTGGAGTTGCCGAGAAATGTATTGGTCAGTCCCACTCCTCTGGCCAATCCCCCTGTAC
CTGGGAGCTTTCCTAACAACAGTGGGCTGAATCCTCAGAATTCTACTGTGTCTGTGGCTGCAGTTGGGGGTGTTGTTGAGGATAACAAGG
AGAGCTTGAATGTGCCTCAGGACAGTGATTGCCAGAATTCCCAGAGTAGGAAGGAACAGGTAAACATTGAACTAAAAGCAGTCCCTGCCC
AAGAAGTTAAAATGGTTGTCCCTGAAGATCAGTCCAAAAAGGATGGGCAGCCTTCGGATCCTAACAAACTTCCCAGTGTCGAAGAGAACA
AAAATTTGGTGTCTCCTGCTATGAGGGAAGCACCAACATCGTTAAGTCAACTTCTTGACAACTCTGGAGCTCCCAATGTGACAATTAAAC
CCCCTGGGCTTACAGATCTGGAAGTAACACCTCCAGTAGTTTCTGGGGAGGACCTCAAAAAAGCATCTGTCATTCCCACACTGCAGGATC
TGTCTTCTTCTAAAGAACCTTCTAATTCCCTAAACTTACCTCACAGTAATGAGCTGTGTTCATCCCTTGTGCATCCCGAATTGAGTGAGG
TCAGTTCTAACGTTGCACCAAGCATCCCTCCAGTAATGTCAAGACCTGTTAGCTCTTCCTCCATTTCCACTCCCTTGCCCCCAAATCAAA
TAACTGTATTTGTCACTTCCAATCCCATCACAACTTCAGCTAACACATCAGCAGCTTTGCCAACTCACTTGCAGTCTGCATTGATGTCAA
CAGTTGTCACAATGCCCAATGCGGGTAGCAAGGTTATGGTTTCTGAGGGACAGTCAGCTGCTCAGTCTAATGCCCGGCCTCAGTTCATTA
CACCTGTCTTTATCAATTCATCCTCAATAATTCAGGTTATGAAAGGATCACAGCCAAGCACAATTCCTGCAGCCCCACTGACAACCAACT
CTGGCCTGATGCCTCCCTCTGTTGCAGTTGTTGGCCCTTTACACATACCTCAGAACATAAAATTTTCTTCTGCTCCTGTACCGCCTAATG
CCCTCTCCAGTAGTCCTGCTCCAAACATCCAGACAGGTCGACCTTTGGTCCTTAGCTCACGAGCCACCCCTGTTCAGCTTCCTTCCCCTC
CTTGTACGTCTTCTCCAGTTGTCCCTTCTCATCCCCCTGTGCAGCAAGTGAAAGAATTGAATCCAGATGAGGCTAGCCCTCAGGTGAACA
CCTCAGCAGATCAGAACACTCTTCCCTCTTCACAGTCAACCACAATGGTTTCTCCCCTTTTGACCAATAGTCCAGGGTCCTCTGGCAACC
GGCGAAGCCCAGTCTCGTCTAGTAAGGGCAAAGGAAAAGTGGACAAAATTGGCCAAATTTTGTTGACCAAGGCATGTAAGAAAGTTACAG
GCTCTCTTGAGAAAGGGGAAGAACAATATGGTGCAGATGGAGAGACTGAAGGCCAAGGGCTAGACACCACAGCTCCGGGGCTCATGGGAA
CAGAGCAGTTATCCACAGAGCTGGACAGTAAAACCCCAACGCCCCCAGCACCCACTCTGCTAAAAATGACCTCTAGCCCTGTGGGCCCGG
GCACTGCCTCAGCAGGACCCAGCTTACCTGGCGGTGCTCTCCCCACCAGTGTACGCTCGATAGTAACCACTCTGGTACCCTCCGAGCTCA
TCTCCGCCGTACCGACCACAAAAAGCAATCATGGTGGCATAGCATCTGAGTCACTTGCGGGTGGCCTAGTGGAGGAGAAGGTGGGATCCC
ATCCAGAACTTCTACCCAGCATAGCCCCGTCGCAGAATTTAGTCTCAAAGGAAACTTCAACCACAGCACTGCAGGCCTCTGTTGCCAGAC
CAGGAATTTGAGAGCGTATTTTGCGGTAAAACTGGCCGAAGGCTAAAGCTGACCAGACCGGACTCCTTGGTGACCTGTCCTGCACAGGGG
AGTTTACAGAGCAGCCCCTCGATGGAGATCAAGTGATCGGACTGAACAGGAATCCTCGGGGGGTGAACAGCCATTCCTTCGTGACCTGTG
CACGCCTTCTGCAACCCTGGAGCTCTGCTCGGCTAGTCTGACTCGAAAAGGGCGTGACTCAAGCTGACGGGACTCCAGTAGGGACTTTGA
GAGCACATTTTGTAAAAATATTTATCTAGACGCAAATGCTTATCCATGAATGTCCTCTTAGACCATTTGGGGATGAAGCCATCTTAATAA
TTAGTAATAATTAATTAGTAATAATTAGTAAGCATTTTCTCAATGCTCTGATTCCATCATGTTTTCTTAACATGATAACTTAAAAAATTG
ACATCCTTTGTACTTTCTTTAATCTTAAAAAGTACACGGCTTTTTACTTATTTACCTTTTAAATATGCCCCTTTAGCAATTGGAACAAGT
TAAATTGTTAACTAAAAACAGTTTGGAAATTTTATTTCATTCGTTATATCACACCCCCTTGTCATGACTCTGAGTCACGTGCTGCTGTAT
TGCAACGTGCAGGACCATTTTAAACCTGTGTGCTAAAAATTTTCCAGATACTTGCTTTAAAGCTACTTTTGTCCACAAATGAAATACTGT
CACAGTAGACGCTTAAATGCCACGTTTTCATACCAAGAGTCATTCATTACTTCATGTGTCACAAACTGTGGTGTTTGGAATTGGGTTTTT
CAATGAGTGGCTTTACTTATCAATCACAACAGGTAATAGCAATAGACGTTAGTGCAATACAAAGTCACCCTCAATAAATACTGTTAATTG

>In-frame_ENST00000359003_ENST00000335351_TCGA-05-4244-01A_NCOA6_chr20_33324494_-_TCFL5_chr20_61473449_length(amino acids)=1999AA_start in transcript=311_stop in transcript=6310
MAYASGIIFTMVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMES
SKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASG
PGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQL
QQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLP
GPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSP
ASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQ
GQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQ
LMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQN
PMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQ
HGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNL
LQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPSQPVEQ
RPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPM
QQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGGPNNMPSHVVLPQNQ
LMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAG
LFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRRSSPGSSRKT
TPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNS
QSRKEQVNIELKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVV
SGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLVHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSA
NTSAALPTHLQSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPAAPLTTNSGLMPPSVAVVGPL
HIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQST
TMVSPLLTNSPGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTTAPGLMGTEQLSTELDSKTPT
PPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCOA6-TCFL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOA6-TCFL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOA6-TCFL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA6C0014175Endometriosis1CTD_human
HgeneNCOA6C0269102Endometrioma1CTD_human