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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:NCOA7-SERPINB1 (FusionGDB2 ID:57475) |
Fusion Gene Summary for NCOA7-SERPINB1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NCOA7-SERPINB1 | Fusion gene ID: 57475 | Hgene | Tgene | Gene symbol | NCOA7 | SERPINB1 | Gene ID | 135112 | 1992 |
Gene name | nuclear receptor coactivator 7 | serpin family B member 1 | |
Synonyms | ERAP140|ESNA1|NCOA7-AS|Nbla00052|Nbla10993|TLDC4|dJ187J11.3 | EI|ELANH2|HEL-S-27|HEL57|LEI|M/NEI|MNEI|PI-2|PI2 | |
Cytomap | 6q22.31-q22.32 | 6p25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor coactivator 7140 kDa estrogen receptor-associated proteinTBC/LysM-associated domain containing 4estrogen nuclear receptor coactivator 1estrogen receptor associated protein 140 kDaputative protein product of Nbla00052putative protein | leukocyte elastase inhibitorepididymis luminal protein 57epididymis secretory protein Li 27peptidase inhibitor 2protease inhibitor 2 (anti-elastase), monocyte/neutrophil derivedserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8NI08 | . | |
Ensembl transtripts involved in fusion gene | ENST00000368357, ENST00000392477, ENST00000229634, ENST00000487635, | ENST00000380739, ENST00000537185, ENST00000476896, | |
Fusion gene scores | * DoF score | 14 X 9 X 7=882 | 5 X 5 X 3=75 |
# samples | 15 | 6 | |
** MAII score | log2(15/882*10)=-2.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NCOA7 [Title/Abstract] AND SERPINB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NCOA7(126243980)-SERPINB1(2838920), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOA7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11971969 |
Tgene | SERPINB1 | GO:0010951 | negative regulation of endopeptidase activity | 30692621 |
Tgene | SERPINB1 | GO:0044342 | type B pancreatic cell proliferation | 26701651 |
Fusion gene breakpoints across NCOA7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SERPINB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4GH-01A | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
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Fusion Gene ORF analysis for NCOA7-SERPINB1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000368357 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000368357 | ENST00000537185 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000368357 | ENST00000476896 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
In-frame | ENST00000392477 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000392477 | ENST00000537185 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000392477 | ENST00000476896 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
In-frame | ENST00000229634 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000229634 | ENST00000537185 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
5CDS-5UTR | ENST00000229634 | ENST00000476896 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
intron-3CDS | ENST00000487635 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
intron-5UTR | ENST00000487635 | ENST00000537185 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
intron-5UTR | ENST00000487635 | ENST00000476896 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000368357 | NCOA7 | chr6 | 126243980 | + | ENST00000380739 | SERPINB1 | chr6 | 2838920 | - | 5123 | 2875 | 343 | 3846 | 1167 |
ENST00000392477 | NCOA7 | chr6 | 126243980 | + | ENST00000380739 | SERPINB1 | chr6 | 2838920 | - | 5048 | 2800 | 268 | 3771 | 1167 |
ENST00000229634 | NCOA7 | chr6 | 126243980 | + | ENST00000380739 | SERPINB1 | chr6 | 2838920 | - | 4684 | 2436 | 210 | 3407 | 1065 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000368357 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - | 0.000408113 | 0.9995919 |
ENST00000392477 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - | 0.000354322 | 0.9996457 |
ENST00000229634 | ENST00000380739 | NCOA7 | chr6 | 126243980 | + | SERPINB1 | chr6 | 2838920 | - | 0.000440768 | 0.9995592 |
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Fusion Genomic Features for NCOA7-SERPINB1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NCOA7-SERPINB1 |
Go to FGviewer for the breakpoints of chr6:126243980-chr6:2838920 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NCOA7 | . |
FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000229634 | + | 12 | 15 | 4_29 | 726.0 | 828.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000368357 | + | 14 | 17 | 4_29 | 841.0 | 943.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000392477 | + | 13 | 16 | 4_29 | 841.0 | 943.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000229634 | + | 12 | 15 | 114_157 | 726.0 | 828.0 | Domain | LysM |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000368357 | + | 14 | 17 | 114_157 | 841.0 | 943.0 | Domain | LysM |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000392477 | + | 13 | 16 | 114_157 | 841.0 | 943.0 | Domain | LysM |
Tgene | SERPINB1 | chr6:126243980 | chr6:2838920 | ENST00000380739 | 1 | 7 | 351_379 | 56.0 | 380.0 | Region | CARD-binding motif (CBM) |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000229634 | + | 12 | 15 | 781_942 | 726.0 | 828.0 | Domain | TLDc |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000368357 | + | 14 | 17 | 781_942 | 841.0 | 943.0 | Domain | TLDc |
Hgene | NCOA7 | chr6:126243980 | chr6:2838920 | ENST00000392477 | + | 13 | 16 | 781_942 | 841.0 | 943.0 | Domain | TLDc |
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Fusion Gene Sequence for NCOA7-SERPINB1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000368357_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(transcript)=5123nt_BP=2875nt AGAAACCCTCATAAAGTAGATGCAGAGGGCAGTAAGATATAACTCAACTTTGAAAATGTCAGCCGTTATAGTTGAAGAAATCTGACCCAA GAGACTTCGCTCCGCTGCAAGATGGAAGGAAGCTTAAGTAAGACATAAATTTGTAATGAACTTGCTCACAACATCCGCCGCCACTGTGAC TTGCAGTCATCATCCATTACCACAAAATTAGTTGCAGGATGGCTACTCGTATCCCTCCACACATGATCATCAGTATTTGCCTCCTGTGTC CCAACCGGCCTGAGTCAAGGTTACGACTCACTGATTAAAAAGAGGGACTTTTTCAAATACTTTGCACTTTTGATTGTGTATTATGGATAC CAAGGAAGAGAAGAAGGAACGGAAACAAAGTTATTTTGCTCGACTGAAAAAGAAAAAACAAGCCAAACAAAATGCAGAGACAGCCTCAGC TGTAGCTACAAGGACTCATACTGGGAAGGAAGATAATAATACAGTAGTTTTAGAGCCAGACAAGTGCAACATTGCTGTGGAAGAGGAATA TATGACTGATGAGAAAAAAAAGAGAAAAAGTAATCAGTTAAAGGAGATCAGGCGTACAGAACTAAAGAGATATTATAGTATTGATGACAA TCAAAACAAAACACATGATAAAAAAGAGAAGAAGATGGTGGTTCAGAAGCCCCATGGGACTATGGAATACACTGCTGGAAACCAGGACAC CCTAAACTCCATAGCACTGAAATTTAACATCACTCCCAATAAATTGGTGGAACTGAATAAACTTTTCACACATACTATTGTTCCAGGCCA GGTCCTTTTTGTGCCAGATGCCAACTCTCCTTCCAGTACCTTAAGGCTATCATCATCCAGTCCTGGTGCTACTGTCTCTCCTTCATCATC AGATGCAGAATATGATAAATTGCCTGATGCTGACTTAGCACGAAAGGCCTTGAAACCCATTGAAAGAGTCTTATCGTCTACTTCTGAAGA AGATGAGCCAGGTGTGGTGAAATTTTTAAAAATGAATTGTCGATACTTCACCGATGGAAAGGGTGTGGTTGGCGGTGTTATGATAGTGAC TCCTAACAACATCATGTTTGACCCTCATAAATCTGATCCTCTGGTTATTGAAAATGGGTGTGAGGAGTATGGTCTCATCTGCCCCATGGA AGAGGTTGTTTCCATTGCGCTCTACAATGACATTTCTCACATGAAGATCAAAGATGCCTTGCCATCTGACCTACCTCAGGATCTTTGTCC TCTGTACAGGCCTGGAGAATGGGAAGACCTGGCTTCAGAAAAGGATATCAACCCATTCAGTAAGTTCAAATCTATCAACAAGGAAAAACG ACAGCAGAATGGAGAGAAAATTATGACTTCGGATTCCAGACCAATAGTACCTTTGGAGAAGTCCACAGGACATACACCTACAAAGCCCTC AGGCAGCTCTGTGTCAGAGAAATTAAAGAAACTGGACTCCTCTAGGGAGACATCCCATGGTTCTCCCACAGTGACTAAGCTCAGCAAGGA ACCTTCCGACACTTCTTCTGCATTTGAATCTACAGCCAAAGAAAACTTTCTAGGGGAAGATGATGATTTTGTTGACTTGGAAGAACTTTC TTCTCAAACTGGTGGTGGAATGCACAAAAAAGACACCTTGAAGGAGTGCCTTTCTCTTGACCCAGAGGAACGAAAGAAAGCTGAGTCACA AATAAACAATTCTGCCGTGGAAATGCAGGTGCAGTCAGCCCTAGCCTTTTTGGGAACAGAGAATGATGTTGAACTGAAGGGGGCGCTAGA TTTAGAAACCTGTGAGAAGCAAGATATAATGCCAGAAGTGGACAAGCAGTCTGGTTCGCCAGAAAGCCGAGTAGAAAACACACTGAACAT ACATGAAGATTTAGATAAAGTTAAACTCATTGAATATTACCTGACTAAGAACAAAGAAGGGCCACAGGTATCTGAAAATTTGCAGAAAAC AGAATTAAGTGATGGAAAAAGTATTGAACCAGGGGGAATAGACATTACCCTTAGTAGTTCTCTTTCCCAGGCGGGTGATCCCATAACTGA GGGCAATAAAGAGCCAGATAAGACCTGGGTGAAAAAGGGAGAGCCCCTCCCGGTAAAACTGAACTCTTCTACAGAAGCAAATGTGATTAA AGAGGCTCTAGACTCCTCTTTGGAATCTACTCTGGACAACAGCTGTCAAGGTGCACAAATGGATAATAAATCTGAAGTTCAGTTGTGGCT GTTAAAGAGAATTCAGGTACCCATTGAAGATATACTTCCTTCAAAAGAAGAAAAAAGCAAGACCCCACCCATGTTCCTGTGCATCAAAGT GGGAAAACCAATGAGAAAATCCTTTGCCACTCACACTGCAGCCATGGTCCAGCAGTACGGCAAACGGAGAAAGCAGCCAGAGTACTGGTT TGCTGTTCCTCGGGAGAGGGTGGATCATTTGTACACATTCTTTGTTCAGTGGTCTCCCGATGTCTATGGAAAAGATGCCAAAGAGCAAGG CTTTGTGGTGGTGGAGAAGGAAGAACTGAACATGATTGACAACTTCTTCAGTGAGCCAACAACCAAGAGCTGGGAGATCATCACTGTTGA AGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGAGGACGAAGAGGTGCTGCCTGTCCTACGGCCCCACAGCGCGCTCCT GGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAGGGTGCAAGGGTATCCATGGAGACTGGCCTATAGCACGTTAGAGCA CGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGACAGTCCTGTCCTATTGGTCATCAAAGATATGGATAATCAGACTTT CCATTTCAACACGGTTGAAGAGGTTCATTCAAGATTCCAGAGTCTGAATGCTGATATCAACAAACGTGGAGCGTCTTATATTCTGAAACT TGCTAATAGATTATATGGAGAGAAAACTTACAATTTCCTTCCTGAGTTCTTGGTTTCGACTCAGAAAACATATGGTGCTGACCTGGCCAG TGTGGATTTTCAGCATGCCTCTGAAGATGCAAGGAAGACCATAAACCAGTGGGTCAAAGGACAGACAGAAGGAAAAATTCCGGAACTGTT GGCTTCGGGCATGGTTGATAACATGACCAAACTTGTGCTAGTAAATGCCATCTATTTCAAGGGAAACTGGAAGGATAAATTCATGAAAGA AGCCACGACGAATGCACCATTCAGATTGAATAAGAAAGACAGAAAAACTGTGAAAATGATGTATCAGAAGAAAAAATTTGCATATGGCTA CATCGAGGACCTTAAGTGCCGTGTGCTGGAACTGCCTTACCAAGGCGAGGAGCTCAGCATGGTCATCCTGCTGCCGGATGACATTGAGGA CGAGTCCACGGGCCTGAAGAAGATTGAGGAACAGTTGACTTTGGAAAAGTTGCATGAGTGGACTAAACCTGAGAATCTCGATTTCATTGA AGTTAATGTCAGCTTGCCCAGGTTCAAACTGGAAGAGAGTTACACTCTCAACTCCGACCTCGCCCGCCTAGGTGTGCAGGATCTCTTTAA CAGTAGCAAGGCTGATCTGTCTGGCATGTCAGGAGCCAGAGATATTTTTATATCAAAAATTGTCCACAAGTCATTTGTGGAAGTGAATGA AGAGGGAACAGAGGCGGCAGCTGCCACAGCAGGCATCGCAACTTTCTGCATGTTGATGCCCGAAGAAAATTTCACTGCCGACCATCCATT CCTTTTCTTTATTCGGCATAATTCCTCAGGTAGCATCCTATTCTTGGGGAGATTTTCTTCCCCTTAGAAGAAAGAGACTGTAGCAATACA AAAATCAAGCTTAGTGCTTTATTACCTGAGTTTTTAATAGAGCCAATATGTCTTATATCTTTACCAATAAAACCACTGTTCAGAAACAAG TCTTTCATTTTCTTTGTAAGTTTGGCTCTGTTGGCTGTTTACACCCATGAATTTTGGCATGGGTATCTATTTTTCTTTTTTACATTGAAA AAAATCCAGTGGTTGCTTTTGAATGCATCAAGTAAAGAAGAAGAAAAGAATACATCCGATGCGTAGATTCTTGACCATGTAGTAATCTAT AAAATTGCTATATCCTCCTGATAGCCATGGGAAAACATGATAAGATGGTCATTTATTTTGCAGTTAGAATTTTGGAAGCCACAAAATAGA CAGACACCCTGACTGTTGAAGGGAGGTTTAAAAACAGATATTCAATTGAAATGTAAGAGAGCACCCCAATTGAGAGCCCAGGTTACGAAG ACAAGCTTGCCTCGCCTGACTTTTCTGTCCCTTGTTCTGCAGGATTAGTATTCTGTTACAGACCTCTAGTTTTTAGACTCTTCAATTAAA GGGCCAATGGTTATAACCTGCATTCCCTTTTTTGTTCTTCTTTATGTATAATATATAGTTCATGTGGCGCTGCATGAAATCAAGAAGTGG GTGTCTTAGGATAAAAGATACCAAGAGTCTACAAAAATAACCATGTAGTAAGATAAACTGCTGAACAAAGGTTTTACTGTTAGCCACCTT CTCATGTGTTTTCTTTTCTCTTTTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTTACCCAGGCTGG AGTGCAGTGGCACGATCTCAGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCTTGCTTCAGCCTCCTGAGTAGCTGGGATTA TAGGCATGCACCACTAGGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTTCCATGTTGGCCAGGCTGGTCCCGAACTCCTGA CCTCAGGTGATCCGCGCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCATGCCTGGCCTTCTCATGTGTTTTCTGATT AAGGCTCTTGACTTCCAAGGCTGTGTGGGGAGATGGGGTGGGGGCTCTTGGACTGATATAAAACTTTGTCAAATGTAGTTCTTTGAATGG >In-frame_ENST00000368357_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(amino acids)=1167AA_start in transcript=343_stop in transcript=3846 MCIMDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRY YSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGAT VSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYG LICPMEEVVSIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGH TPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEER KKAESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVS ENLQKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKS EVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGK DAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLA YSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTY GADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKK KFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLG -------------------------------------------------------------- >In-frame_ENST00000392477_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(transcript)=5048nt_BP=2800nt CGATCCGGACGCGGGGCCCCGCGGGCGCGCGCCTCGGAGCTCCCGCCTCCTCCTCTTGCTCCTCCTCGGCGTACGGTCCTCCCCTGACCC CTCCTTCCACCCGCCGAGAGGATGCGCTCCCCGGCGCCCAGCAGCAGAGGCCACCGCTCCCAGAAATGCATGCGACCGATCCCCTTCTCC CGGACCCCAGGAGCCGGCGCCCCCGCCCTGTAGGGTTACGACTCACTGATTAAAAAGAGGGACTTTTTCAAATACTTTGCACTTTTGATT GTGTATTATGGATACCAAGGAAGAGAAGAAGGAACGGAAACAAAGTTATTTTGCTCGACTGAAAAAGAAAAAACAAGCCAAACAAAATGC AGAGACAGCCTCAGCTGTAGCTACAAGGACTCATACTGGGAAGGAAGATAATAATACAGTAGTTTTAGAGCCAGACAAGTGCAACATTGC TGTGGAAGAGGAATATATGACTGATGAGAAAAAAAAGAGAAAAAGTAATCAGTTAAAGGAGATCAGGCGTACAGAACTAAAGAGATATTA TAGTATTGATGACAATCAAAACAAAACACATGATAAAAAAGAGAAGAAGATGGTGGTTCAGAAGCCCCATGGGACTATGGAATACACTGC TGGAAACCAGGACACCCTAAACTCCATAGCACTGAAATTTAACATCACTCCCAATAAATTGGTGGAACTGAATAAACTTTTCACACATAC TATTGTTCCAGGCCAGGTCCTTTTTGTGCCAGATGCCAACTCTCCTTCCAGTACCTTAAGGCTATCATCATCCAGTCCTGGTGCTACTGT CTCTCCTTCATCATCAGATGCAGAATATGATAAATTGCCTGATGCTGACTTAGCACGAAAGGCCTTGAAACCCATTGAAAGAGTCTTATC GTCTACTTCTGAAGAAGATGAGCCAGGTGTGGTGAAATTTTTAAAAATGAATTGTCGATACTTCACCGATGGAAAGGGTGTGGTTGGCGG TGTTATGATAGTGACTCCTAACAACATCATGTTTGACCCTCATAAATCTGATCCTCTGGTTATTGAAAATGGGTGTGAGGAGTATGGTCT CATCTGCCCCATGGAAGAGGTTGTTTCCATTGCGCTCTACAATGACATTTCTCACATGAAGATCAAAGATGCCTTGCCATCTGACCTACC TCAGGATCTTTGTCCTCTGTACAGGCCTGGAGAATGGGAAGACCTGGCTTCAGAAAAGGATATCAACCCATTCAGTAAGTTCAAATCTAT CAACAAGGAAAAACGACAGCAGAATGGAGAGAAAATTATGACTTCGGATTCCAGACCAATAGTACCTTTGGAGAAGTCCACAGGACATAC ACCTACAAAGCCCTCAGGCAGCTCTGTGTCAGAGAAATTAAAGAAACTGGACTCCTCTAGGGAGACATCCCATGGTTCTCCCACAGTGAC TAAGCTCAGCAAGGAACCTTCCGACACTTCTTCTGCATTTGAATCTACAGCCAAAGAAAACTTTCTAGGGGAAGATGATGATTTTGTTGA CTTGGAAGAACTTTCTTCTCAAACTGGTGGTGGAATGCACAAAAAAGACACCTTGAAGGAGTGCCTTTCTCTTGACCCAGAGGAACGAAA GAAAGCTGAGTCACAAATAAACAATTCTGCCGTGGAAATGCAGGTGCAGTCAGCCCTAGCCTTTTTGGGAACAGAGAATGATGTTGAACT GAAGGGGGCGCTAGATTTAGAAACCTGTGAGAAGCAAGATATAATGCCAGAAGTGGACAAGCAGTCTGGTTCGCCAGAAAGCCGAGTAGA AAACACACTGAACATACATGAAGATTTAGATAAAGTTAAACTCATTGAATATTACCTGACTAAGAACAAAGAAGGGCCACAGGTATCTGA AAATTTGCAGAAAACAGAATTAAGTGATGGAAAAAGTATTGAACCAGGGGGAATAGACATTACCCTTAGTAGTTCTCTTTCCCAGGCGGG TGATCCCATAACTGAGGGCAATAAAGAGCCAGATAAGACCTGGGTGAAAAAGGGAGAGCCCCTCCCGGTAAAACTGAACTCTTCTACAGA AGCAAATGTGATTAAAGAGGCTCTAGACTCCTCTTTGGAATCTACTCTGGACAACAGCTGTCAAGGTGCACAAATGGATAATAAATCTGA AGTTCAGTTGTGGCTGTTAAAGAGAATTCAGGTACCCATTGAAGATATACTTCCTTCAAAAGAAGAAAAAAGCAAGACCCCACCCATGTT CCTGTGCATCAAAGTGGGAAAACCAATGAGAAAATCCTTTGCCACTCACACTGCAGCCATGGTCCAGCAGTACGGCAAACGGAGAAAGCA GCCAGAGTACTGGTTTGCTGTTCCTCGGGAGAGGGTGGATCATTTGTACACATTCTTTGTTCAGTGGTCTCCCGATGTCTATGGAAAAGA TGCCAAAGAGCAAGGCTTTGTGGTGGTGGAGAAGGAAGAACTGAACATGATTGACAACTTCTTCAGTGAGCCAACAACCAAGAGCTGGGA GATCATCACTGTTGAAGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGAGGACGAAGAGGTGCTGCCTGTCCTACGGCC CCACAGCGCGCTCCTGGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAGGGTGCAAGGGTATCCATGGAGACTGGCCTA TAGCACGTTAGAGCACGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGACAGTCCTGTCCTATTGGTCATCAAAGATAT GGATAATCAGACTTTCCATTTCAACACGGTTGAAGAGGTTCATTCAAGATTCCAGAGTCTGAATGCTGATATCAACAAACGTGGAGCGTC TTATATTCTGAAACTTGCTAATAGATTATATGGAGAGAAAACTTACAATTTCCTTCCTGAGTTCTTGGTTTCGACTCAGAAAACATATGG TGCTGACCTGGCCAGTGTGGATTTTCAGCATGCCTCTGAAGATGCAAGGAAGACCATAAACCAGTGGGTCAAAGGACAGACAGAAGGAAA AATTCCGGAACTGTTGGCTTCGGGCATGGTTGATAACATGACCAAACTTGTGCTAGTAAATGCCATCTATTTCAAGGGAAACTGGAAGGA TAAATTCATGAAAGAAGCCACGACGAATGCACCATTCAGATTGAATAAGAAAGACAGAAAAACTGTGAAAATGATGTATCAGAAGAAAAA ATTTGCATATGGCTACATCGAGGACCTTAAGTGCCGTGTGCTGGAACTGCCTTACCAAGGCGAGGAGCTCAGCATGGTCATCCTGCTGCC GGATGACATTGAGGACGAGTCCACGGGCCTGAAGAAGATTGAGGAACAGTTGACTTTGGAAAAGTTGCATGAGTGGACTAAACCTGAGAA TCTCGATTTCATTGAAGTTAATGTCAGCTTGCCCAGGTTCAAACTGGAAGAGAGTTACACTCTCAACTCCGACCTCGCCCGCCTAGGTGT GCAGGATCTCTTTAACAGTAGCAAGGCTGATCTGTCTGGCATGTCAGGAGCCAGAGATATTTTTATATCAAAAATTGTCCACAAGTCATT TGTGGAAGTGAATGAAGAGGGAACAGAGGCGGCAGCTGCCACAGCAGGCATCGCAACTTTCTGCATGTTGATGCCCGAAGAAAATTTCAC TGCCGACCATCCATTCCTTTTCTTTATTCGGCATAATTCCTCAGGTAGCATCCTATTCTTGGGGAGATTTTCTTCCCCTTAGAAGAAAGA GACTGTAGCAATACAAAAATCAAGCTTAGTGCTTTATTACCTGAGTTTTTAATAGAGCCAATATGTCTTATATCTTTACCAATAAAACCA CTGTTCAGAAACAAGTCTTTCATTTTCTTTGTAAGTTTGGCTCTGTTGGCTGTTTACACCCATGAATTTTGGCATGGGTATCTATTTTTC TTTTTTACATTGAAAAAAATCCAGTGGTTGCTTTTGAATGCATCAAGTAAAGAAGAAGAAAAGAATACATCCGATGCGTAGATTCTTGAC CATGTAGTAATCTATAAAATTGCTATATCCTCCTGATAGCCATGGGAAAACATGATAAGATGGTCATTTATTTTGCAGTTAGAATTTTGG AAGCCACAAAATAGACAGACACCCTGACTGTTGAAGGGAGGTTTAAAAACAGATATTCAATTGAAATGTAAGAGAGCACCCCAATTGAGA GCCCAGGTTACGAAGACAAGCTTGCCTCGCCTGACTTTTCTGTCCCTTGTTCTGCAGGATTAGTATTCTGTTACAGACCTCTAGTTTTTA GACTCTTCAATTAAAGGGCCAATGGTTATAACCTGCATTCCCTTTTTTGTTCTTCTTTATGTATAATATATAGTTCATGTGGCGCTGCAT GAAATCAAGAAGTGGGTGTCTTAGGATAAAAGATACCAAGAGTCTACAAAAATAACCATGTAGTAAGATAAACTGCTGAACAAAGGTTTT ACTGTTAGCCACCTTCTCATGTGTTTTCTTTTCTCTTTTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGACAGAGTCTTGCTC TGTTACCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCTTGCTTCAGCCTCCT GAGTAGCTGGGATTATAGGCATGCACCACTAGGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTTCCATGTTGGCCAGGCTG GTCCCGAACTCCTGACCTCAGGTGATCCGCGCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCATGCCTGGCCTTCTC ATGTGTTTTCTGATTAAGGCTCTTGACTTCCAAGGCTGTGTGGGGAGATGGGGTGGGGGCTCTTGGACTGATATAAAACTTTGTCAAATG TAGTTCTTTGAATGGAGCTTGAAACGCCGCATATTCTTGCTCCCACAAGGATAGTGGGCATCATGAATTAATAAAACGTCCTAGGATTCT >In-frame_ENST00000392477_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(amino acids)=1167AA_start in transcript=268_stop in transcript=3771 MCIMDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRY YSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGAT VSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYG LICPMEEVVSIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGH TPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEER KKAESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVS ENLQKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKS EVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGK DAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLA YSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTY GADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKK KFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLG -------------------------------------------------------------- >In-frame_ENST00000229634_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(transcript)=4684nt_BP=2436nt GATGCGCTCCCCGGCGCCCAGCAGCAGAGGCCACCGCTCCCAGAAATGCATGCGACCGATCCCCTTCTCCCGGACCCCAGGAGCCGGCGC CCCCGCCCTGTAGGGTTACGACTCACTGATTAAAAAGAGGGACTTTTTCAAATACTTTGCACTTTTGATTGTGTATTATGGATACCAAGG AAGAGAAGAAGGAACGGAAACAAAGTTATTTTGCTCGATGACAATCAAAACAAAACACATGATAAAAAAGAGAAGAAGATGGTGGTTCAG AAGCCCCATGGGACTATGGAATACACTGCTGGAAACCAGGACACCCTAAACTCCATAGCACTGAAATTTAACATCACTCCCAATAAATTG GTGGAACTGAATAAACTTTTCACACATACTATTGTTCCAGGCCAGGTCCTTTTTGTGCCAGATGCCAACTCTCCTTCCAGTACCTTAAGG CTATCATCATCCAGTCCTGGTGCTACTGTCTCTCCTTCATCATCAGATGCAGAATATGATAAATTGCCTGATGCTGACTTAGCACGAAAG GCCTTGAAACCCATTGAAAGAGTCTTATCGTCTACTTCTGAAGAAGATGAGCCAGGTGTGGTGAAATTTTTAAAAATGAATTGTCGATAC TTCACCGATGGAAAGGGTGTGGTTGGCGGTGTTATGATAGTGACTCCTAACAACATCATGTTTGACCCTCATAAATCTGATCCTCTGGTT ATTGAAAATGGGTGTGAGGAGTATGGTCTCATCTGCCCCATGGAAGAGGTTGTTTCCATTGCGCTCTACAATGACATTTCTCACATGAAG ATCAAAGATGCCTTGCCATCGCCTGGAGAATGGGAAGACCTGGCTTCAGAAAAGGATATCAACCCATTCAGTAAGTTCAAATCTATCAAC AAGGAAAAACGACAGCAGAATGGAGAGAAAATTATGACTTCGGATTCCAGACCAATAGTACCTTTGGAGAAGTCCACAGGACATACACCT ACAAAGCCCTCAGGCAGCTCTGTGTCAGAGAAATTAAAGAAACTGGACTCCTCTAGGGAGACATCCCATGGTTCTCCCACAGTGACTAAG CTCAGCAAGGAACCTTCCGACACTTCTTCTGCATTTGAATCTACAGCCAAAGAAAACTTTCTAGGGGAAGATGATGATTTTGTTGACTTG GAAGAACTTTCTTCTCAAACTGGTGGTGGAATGCACAAAAAAGACACCTTGAAGGAGTGCCTTTCTCTTGACCCAGAGGAACGAAAGAAA GCTGAGTCACAAATAAACAATTCTGCCGTGGAAATGCAGGTGCAGTCAGCCCTAGCCTTTTTGGGAACAGAGAATGATGTTGAACTGAAG GGGGCGCTAGATTTAGAAACCTGTGAGAAGCAAGATATAATGCCAGAAGTGGACAAGCAGTCTGGTTCGCCAGAAAGCCGAGTAGAAAAC ACACTGAACATACATGAAGATTTAGATAAAGTTAAACTCATTGAATATTACCTGACTAAGAACAAAGAAGGGCCACAGGTATCTGAAAAT TTGCAGAAAACAGAATTAAGTGATGGAAAAAGTATTGAACCAGGGGGAATAGACATTACCCTTAGTAGTTCTCTTTCCCAGGCGGGTGAT CCCATAACTGAGGGCAATAAAGAGCCAGATAAGACCTGGGTGAAAAAGGGAGAGCCCCTCCCGGTAAAACTGAACTCTTCTACAGAAGCA AATGTGATTAAAGAGGCTCTAGACTCCTCTTTGGAATCTACTCTGGACAACAGCTGTCAAGGTGCACAAATGGATAATAAATCTGAAGTT CAGTTGTGGCTGTTAAAGAGAATTCAGGTACCCATTGAAGATATACTTCCTTCAAAAGAAGAAAAAAGCAAGACCCCACCCATGTTCCTG TGCATCAAAGTGGGAAAACCAATGAGAAAATCCTTTGCCACTCACACTGCAGCCATGGTCCAGCAGTACGGCAAACGGAGAAAGCAGCCA GAGTACTGGTTTGCTGTTCCTCGGGAGAGGGTGGATCATTTGTACACATTCTTTGTTCAGTGGTCTCCCGATGTCTATGGAAAAGATGCC AAAGAGCAAGGCTTTGTGGTGGTGGAGAAGGAAGAACTGAACATGATTGACAACTTCTTCAGTGAGCCAACAACCAAGAGCTGGGAGATC ATCACTGTTGAAGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGAGGACGAAGAGGTGCTGCCTGTCCTACGGCCCCAC AGCGCGCTCCTGGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAGGGTGCAAGGGTATCCATGGAGACTGGCCTATAGC ACGTTAGAGCACGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGACAGTCCTGTCCTATTGGTCATCAAAGATATGGAT AATCAGACTTTCCATTTCAACACGGTTGAAGAGGTTCATTCAAGATTCCAGAGTCTGAATGCTGATATCAACAAACGTGGAGCGTCTTAT ATTCTGAAACTTGCTAATAGATTATATGGAGAGAAAACTTACAATTTCCTTCCTGAGTTCTTGGTTTCGACTCAGAAAACATATGGTGCT GACCTGGCCAGTGTGGATTTTCAGCATGCCTCTGAAGATGCAAGGAAGACCATAAACCAGTGGGTCAAAGGACAGACAGAAGGAAAAATT CCGGAACTGTTGGCTTCGGGCATGGTTGATAACATGACCAAACTTGTGCTAGTAAATGCCATCTATTTCAAGGGAAACTGGAAGGATAAA TTCATGAAAGAAGCCACGACGAATGCACCATTCAGATTGAATAAGAAAGACAGAAAAACTGTGAAAATGATGTATCAGAAGAAAAAATTT GCATATGGCTACATCGAGGACCTTAAGTGCCGTGTGCTGGAACTGCCTTACCAAGGCGAGGAGCTCAGCATGGTCATCCTGCTGCCGGAT GACATTGAGGACGAGTCCACGGGCCTGAAGAAGATTGAGGAACAGTTGACTTTGGAAAAGTTGCATGAGTGGACTAAACCTGAGAATCTC GATTTCATTGAAGTTAATGTCAGCTTGCCCAGGTTCAAACTGGAAGAGAGTTACACTCTCAACTCCGACCTCGCCCGCCTAGGTGTGCAG GATCTCTTTAACAGTAGCAAGGCTGATCTGTCTGGCATGTCAGGAGCCAGAGATATTTTTATATCAAAAATTGTCCACAAGTCATTTGTG GAAGTGAATGAAGAGGGAACAGAGGCGGCAGCTGCCACAGCAGGCATCGCAACTTTCTGCATGTTGATGCCCGAAGAAAATTTCACTGCC GACCATCCATTCCTTTTCTTTATTCGGCATAATTCCTCAGGTAGCATCCTATTCTTGGGGAGATTTTCTTCCCCTTAGAAGAAAGAGACT GTAGCAATACAAAAATCAAGCTTAGTGCTTTATTACCTGAGTTTTTAATAGAGCCAATATGTCTTATATCTTTACCAATAAAACCACTGT TCAGAAACAAGTCTTTCATTTTCTTTGTAAGTTTGGCTCTGTTGGCTGTTTACACCCATGAATTTTGGCATGGGTATCTATTTTTCTTTT TTACATTGAAAAAAATCCAGTGGTTGCTTTTGAATGCATCAAGTAAAGAAGAAGAAAAGAATACATCCGATGCGTAGATTCTTGACCATG TAGTAATCTATAAAATTGCTATATCCTCCTGATAGCCATGGGAAAACATGATAAGATGGTCATTTATTTTGCAGTTAGAATTTTGGAAGC CACAAAATAGACAGACACCCTGACTGTTGAAGGGAGGTTTAAAAACAGATATTCAATTGAAATGTAAGAGAGCACCCCAATTGAGAGCCC AGGTTACGAAGACAAGCTTGCCTCGCCTGACTTTTCTGTCCCTTGTTCTGCAGGATTAGTATTCTGTTACAGACCTCTAGTTTTTAGACT CTTCAATTAAAGGGCCAATGGTTATAACCTGCATTCCCTTTTTTGTTCTTCTTTATGTATAATATATAGTTCATGTGGCGCTGCATGAAA TCAAGAAGTGGGTGTCTTAGGATAAAAGATACCAAGAGTCTACAAAAATAACCATGTAGTAAGATAAACTGCTGAACAAAGGTTTTACTG TTAGCCACCTTCTCATGTGTTTTCTTTTCTCTTTTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTT ACCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCTTGCTTCAGCCTCCTGAGT AGCTGGGATTATAGGCATGCACCACTAGGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTTCCATGTTGGCCAGGCTGGTCC CGAACTCCTGACCTCAGGTGATCCGCGCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCATGCCTGGCCTTCTCATGT GTTTTCTGATTAAGGCTCTTGACTTCCAAGGCTGTGTGGGGAGATGGGGTGGGGGCTCTTGGACTGATATAAAACTTTGTCAAATGTAGT TCTTTGAATGGAGCTTGAAACGCCGCATATTCTTGCTCCCACAAGGATAGTGGGCATCATGAATTAATAAAACGTCCTAGGATTCTGCAA >In-frame_ENST00000229634_ENST00000380739_TCGA-HU-A4GH-01A_NCOA7_chr6_126243980_+_SERPINB1_chr6_2838920_length(amino acids)=1065AA_start in transcript=210_stop in transcript=3407 MLDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATV SPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGL ICPMEEVVSIALYNDISHMKIKDALPSPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPTKPSGSSVSE KLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAV EMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENLQKTELSDGK SIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQV PIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEK EELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKT LYRKSASLDSPVLLVIKDMDNQTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHA SEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKC RVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NCOA7-SERPINB1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NCOA7-SERPINB1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NCOA7-SERPINB1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOA7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | NCOA7 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |