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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR1-ACER3 (FusionGDB2 ID:57480)

Fusion Gene Summary for NCOR1-ACER3

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1-ACER3
Fusion gene ID: 57480
HgeneTgene
Gene symbol

NCOR1

ACER3

Gene ID

9611

55331

Gene namenuclear receptor corepressor 1alkaline ceramidase 3
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRAPHC|PHCA|PLDECO
Cytomap

17p12-p11.2

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1alkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline
Modification date2020031320200320
UniProtAcc

O75376

Q9NUN7

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 		ENST00000532485, 
ENST00000530182, ENST00000526597, 
ENST00000533873, ENST00000538157, 
ENST00000544113, 
Fusion gene scores* DoF score30 X 30 X 13=1170013 X 10 X 5=650
# samples 3315
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/650*10)=-2.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR1(15995177)-ACER3(76579164), # samples:2
NCOR1(15995177)-ACER3(76637601), # samples:2
Anticipated loss of major functional domain due to fusion event.NCOR1-ACER3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-ACER3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-ACER3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR1-ACER3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-ACER3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768

TgeneACER3

GO:0043067

regulation of programmed cell death

20068046

TgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

TgeneACER3

GO:0046514

ceramide catabolic process

30575723

TgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACER3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A2LJ-01ANCOR1chr17

15995177

-ACER3chr11

76579164

+
ChimerDB4BRCATCGA-AR-A2LJ-01ANCOR1chr17

15995177

-ACER3chr11

76579164

+
ChimerDB4BRCATCGA-AR-A2LJ-01ANCOR1chr17

15995177

-ACER3chr11

76637601

+
ChimerDB4BRCATCGA-AR-A2LJ-01ANCOR1chr17

15995177

-ACER3chr11

76637601

+


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Fusion Gene ORF analysis for NCOR1-ACER3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000268712ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000268712ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000268712ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000268712ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-5UTRENST00000268712ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000268712ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000395851ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000395851ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000395851ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000395851ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-5UTRENST00000395851ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76579164

+
5CDS-intronENST00000395851ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395857ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395857ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395857ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395857ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-5UTRENST00000395857ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395857ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395848ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395848ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395848ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395848ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-5UTRENST00000395848ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000395848ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000583226ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000583226ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000583226ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000583226ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-5UTRENST00000583226ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76579164

+
intron-intronENST00000583226ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76579164

+
Frame-shiftENST00000268712ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-3UTRENST00000268712ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-5UTRENST00000268712ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-intronENST00000268712ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-5UTRENST00000268712ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-intronENST00000268712ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76637601

+
In-frameENST00000395851ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-3UTRENST00000395851ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-5UTRENST00000395851ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-intronENST00000395851ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-5UTRENST00000395851ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76637601

+
5CDS-intronENST00000395851ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3CDSENST00000395857ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3UTRENST00000395857ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000395857ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000395857ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000395857ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000395857ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3CDSENST00000395848ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3UTRENST00000395848ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000395848ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000395848ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000395848ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000395848ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3CDSENST00000583226ENST00000532485NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-3UTRENST00000583226ENST00000530182NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000583226ENST00000526597NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000583226ENST00000533873NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-5UTRENST00000583226ENST00000538157NCOR1chr17

15995177

-ACER3chr11

76637601

+
intron-intronENST00000583226ENST00000544113NCOR1chr17

15995177

-ACER3chr11

76637601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395851NCOR1chr1715995177-ENST00000532485ACER3chr1176637601+1027931082038081262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395851ENST00000532485NCOR1chr1715995177-ACER3chr1176637601+9.93E-050.9999007

Top

Fusion Genomic Features for NCOR1-ACER3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOR1chr1715995176-ACER3chr1176637600+1.16E-050.99998844
NCOR1chr1715995176-ACER3chr1176579163+5.53E-060.9999945
NCOR1chr1715995176-ACER3chr1176637600+1.16E-050.99998844
NCOR1chr1715995176-ACER3chr1176579163+5.53E-060.9999945

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCOR1-ACER3


check button Go to

FGviewer for the breakpoints of chr17:15995177-chr11:76637601

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

ACER3

Q9NUN7

FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q9D099, ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20068046, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:26792856, ECO:0000269|PubMed:30575723, ECO:0000303|PubMed:20068046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246174_2161005.33333333333342441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246299_3281005.33333333333342441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246501_5571005.33333333333342441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145174_2161021.33333333333342338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145299_3281021.33333333333342338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145501_5571021.33333333333342338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-224658_641005.33333333333342441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246593_6031005.33333333333342441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246607_6171005.33333333333342441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-214558_641021.33333333333342338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145593_6031021.33333333333342338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145607_6171021.33333333333342338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246435_4861005.33333333333342441.0DomainSANT 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246623_6741005.33333333333342441.0DomainSANT 2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145435_4861021.33333333333342338.0DomainSANT 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145623_6741021.33333333333342338.0DomainSANT 2
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011109_11834.333333333333336268.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011140_14134.333333333333336268.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011163_17334.333333333333336268.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011195_21534.333333333333336268.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011237_26734.333333333333336268.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST0000053248501156_6134.333333333333336268.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST0000053248501183_8734.333333333333336268.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306109_1180.0135.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306140_1410.0135.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306163_1730.0135.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306195_2150.0135.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST00000544113061_330.0135.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306237_2670.0135.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST000005441130656_610.0135.0Topological domainLumenal
TgeneACER3chr17:15995177chr11:76637601ENST000005441130683_870.0135.0Topological domainCytoplasmic
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011119_13934.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011142_16234.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011174_19434.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST00000532485011216_23634.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000053248501134_5534.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000053248501162_8234.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000053248501188_10834.333333333333336268.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306119_1390.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306142_1620.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306174_1940.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST0000054411306216_2360.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST000005441130634_550.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST000005441130662_820.0135.0TransmembraneHelical
TgeneACER3chr17:15995177chr11:76637601ENST000005441130688_1080.0135.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119174_2160915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119299_3280915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119501_5570915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461032_10351005.33333333333342441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461707_17121005.33333333333342441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461952_19631005.33333333333342441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191032_10350915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191707_17120915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191952_19630915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-11958_640915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119593_6030915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119607_6170915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451032_10351021.33333333333342338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451707_17121021.33333333333342338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451952_19631021.33333333333342338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119435_4860915.0DomainSANT 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119623_6740915.0DomainSANT 2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461933_19371005.33333333333342441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22462055_20591005.33333333333342441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22462263_22671005.33333333333342441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191933_19370915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1192055_20590915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1192263_22670915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451933_19371021.33333333333342338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21452055_20591021.33333333333342338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21452263_22671021.33333333333342338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22462032_21151005.33333333333342441.0RegionID1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22462212_22731005.33333333333342441.0RegionID2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1192032_21150915.0RegionID1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1192212_22730915.0RegionID2
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21452032_21151021.33333333333342338.0RegionID1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21452212_22731021.33333333333342338.0RegionID2
TgeneACER3chr17:15995177chr11:76637601ENST000005324850111_3334.333333333333336268.0Topological domainCytoplasmic


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Fusion Gene Sequence for NCOR1-ACER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000395851_ENST00000532485_TCGA-AR-A2LJ-01A_NCOR1_chr17_15995177_-_ACER3_chr11_76637601_length(transcript)=10279nt_BP=3108nt
ATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAG
AACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCT
CTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTC
ACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAAT
CGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAG
GGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTG
GAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAG
AACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTC
CTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGGAAAAAAGCAGAAGAAGCTCATAAAATTTTTGAAG
GTCTTGGCCCAAAAGTTGAACTGCCACTGTATAACCAGCCATCAGATACCAAGGTGTACCATGAGAACATCAAGACAAACCAGGTGATGA
GGAAAAAACTCATTTTATTTTTTAAAAGAAGAAATCATGCAAGAAAACAAAGGGAACAAAAAATCTGCCAGCGTTATGATCAGCTCATGG
AGGCATGGGAGAAAAAAGTGGACAGAATAGAAAATAATCCTCGGAGGAAAGCTAAAGAAAGCAAAACAAGGGAATACTATGAAAAGCAGT
TTCCAGAAATTCGAAAACAAAGAGAACAGCAAGAAAGATTTCAGCGAGTTGGGCAGAGGGGAGCTGGTCTTTCAGCCACCATTGCTAGGA
GTGAGCATGAGATTTCTGAAATTATTGATGGGCTCTCTGAGCAGGAGAATAATGAGAAACAAATGCGGCAGCTCTCTGTGATTCCACCTA
TGATGTTTGATGCAGAACAAAGACGAGTCAAGTTCATTAACATGAATGGGCTTATGGAGGACCCTATGAAAGTGTATAAAGATAGGCAGT
TTATGAATGTTTGGACTGACCATGAAAAGGAGATCTTTAAGGACAAGTTTATCCAGCATCCAAAAAACTTTGGACTAATTGCATCATACT
TGGAGAGGAAGAGTGTTCCTGATTGTGTTTTGTATTACTATTTAACCAAGAAAAATGAGAATTATAAAGCCCTCGTCAGAAGGAATTATG
GGAAACGCAGAGGCAGAAACCAGCAAATTGCTCGACCCTCGCAAGAAGAAAAAGTAGAAGAAAAAGAAGAGGATAAAGCAGAAAAAACAG
AAAAAAAAGAAGAAGAAAAGAAAGATGAAGAGGAAAAAGATGAAAAAGAAGACTCCAAAGAAAATACCAAGGAAAAGGACAAGATAGATG
GTACAGCAGAAGAAACTGAGGAAAGAGAGCAAGCCACACCCCGGGGGCGAAAGACTGCCAACAGTCAGGGCCGCCGTAAGGGCCGGATCA
CCAGGTCCATGACAAACGAAGCTGCAGCTGCCAGTGCTGCAGCCGCAGCGGCTACTGAAGAGCCCCCACCACCTCTGCCACCGCCACCAG
AACCCATTTCTACAGAGCCTGTGGAGACCTCTCGATGGACAGAAGAAGAAATGGAAGTTGCTAAAAAAGGTCTAGTAGAACATGGTCGTA
ACTGGGCAGCAATTGCTAAAATGGTGGGAACGAAAAGTGAAGCTCAATGTAAAAACTTCTATTTTAACTATAAAAGGCGACACAATCTTG
ACAACCTCTTACAGCAGCATAAACAGAAAACTTCACGAAAACCTCGTGAAGAGCGAGATGTGTCTCAATGTGAAAGTGTCGCTTCCACTG
TTTCTGCTCAGGAGGATGAAGATATTGAAGCCTCCAATGAAGAAGAAAATCCAGAAGACAGCGAAGGTGCAGAAAATAGTTCTGATACAG
AAAGTGCTCCTTCTCCTTCACCAGTTGAAGCTGTCAAGCCCAGCGAGGACAGTCCTGAAAATGCTACTTCTCGAGGAAACACAGAACCTG
CGGTTGAGCTTGAGCCCACCACGGAAACTGCACCCAGTACATCTCCCTCCTTAGCAGTTCCAAGTACAAAACCAGCTGAAGATGAAAGTG
TGGAGACCCAGGTGAATGACAGCATCAGTGCTGAGACAGCAGAGCAGATGGATGTAGATCAGCAGGAGCACAGTGCTGAAGAGGGTTCTG
TTTGTGATCCCCCACCCGCTACCAAAGCTGACTCTGTGGACGTTGAAGTGAGGGTGCCAGAAAACCATGCATCTAAAGTTGAAGGTGATA
ATACCAAAGAAAGAGACTTGGATAGAGCCAGTGAGAAGGTGGAACCTAGAGATGAAGATTTGGTGGTAGCTCAGCAAATAAATGCCCAAA
GGCCCGAGCCCCAGTCAGACAATGATTCCAGTGCCACGTGCAGCGCTGATGAGGATGTGGATGGAGAGCCAGAGAGGCAGAGAATGTTTC
CTATGGACTCAAAGCCTTCACTGTTAAACCCCACTGGATCTATACTCGTCTCATCTCCGTTAAAACCAAATCCACTGGATCTGCCACAGC
TTCAGCATCGAGCTGCTGTTATCCCACCAATGGTATCCTGCACCCCATGTAACATACCAATTGGAACCCCAGTGAGCGGCTATGCTCTCT
ACCAGCGACACATTAAAGCAATGCATGAGTCAGCACTCCTGGAGGAGCAGCGGCAGAGACAAGAACAGATAGATTTGGAATGTAGAAGTT
CTACAAGTCCATGTGGCACATCCAAGAGTCCAAACAGAGAGTGGGAAGGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGT
TCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAGCGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGT
GCTTCCACATGACTCTGAAATATGAAATGCAGCTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTTG
AATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGG
TAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTATC
CATGGCTTAGAGGACTGGGTTATACATCATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCAC
TGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCT
ATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGA
TCCTGTTTGAGCCTCTCAGGAAGCATTGATGAATCATTCCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAATAAATAAGG
AAATCCTTAAAGATCTACAAGTTCAAATATGTCATGACCATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCACACAGAGAA
TAAGGAGTAGGGCCTGCTGGGTGTTTAGCTCATGGCTTTATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAAAGAAACAGA
GATGATGTGTGTGTATGCCTCAAATGCAGAAACAGTTGGGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAATTAACCTTC
TTTTCTTTTTGCCAAGGGTTGCATGTGAATTATACCTTTCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACAAAACCCCAT
ATCCAGATAGTTAGCTGTGAGCCAGCACTCAGCTGTGTCAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAAAGGTAAAAA
AAGAGAGAGAAAGAGAGAGAGCTAGCTGTGGGATTCTGTGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCATAAGCAAGCT
CAGACCTGCCCCCAGTTCAGTACTTGACCACATCCCAGGATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGTGGGTCATCT
TATAACCTTTCTGAAGCTCCATGAGGACATGTATAGAATGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTTTAAGTTGTC
ACTGTTTCTACGGCTAGACAAATATGACTGGTGGTCTAGACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTTGTCAGGGAA
TGTCATTACACTCTGATTTTTAAAATTATGCAGTATTTTCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGTTGCATTAAC
TAAAGCTAAAATTATCAGAATCCTATTTACATAAAGCATATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGTAAGTTTCTG
CTACTTGAAACCTACAGAACCGACAAAAATTAGGGTGCTAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCTAATTTGCAT
TTGAATGTATAACAAATTGCATCACTTTTCACAAACTTAACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCATGTTTCATC
ATATTTGTAGCTCTGCATCATTTAGCATTTTTATGACTTTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTTACCACATGA
TGACGTGACTCAGGATTAAATCCTGAGCTACAGTTTCAAAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACTGTTGTCATT
TTTTCCAGTATTCAATAAGTAGCCTTTGTACAAATTTAAAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTTAGTTTTTAA
CCAAGTATCCAAGGATGTCAACTTGACATCCTTCCCTTAGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTTATGAACCTC
CAGGAAGAAAAACACTTGCCAAAACATTAAGAGAACTTTGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGCACAGCCCAT
AAGACTATACTTGATTTTGCCCCAAGATTCTGACTTCTGGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATACATTTTTTA
ATTCATTTGTTTTCCACCATTATATTTTTATACTTTTCAGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGGATAAAGGCA
TATCGTACATGGCAATGCTGTTAAACATGGTAAGACTGAGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCACACCTTGATA
CTGAGGCCATTTAGAGCAATTTGTTTAATGAGTGGTTCAGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAGCACCACAGT
GGAGAGTCATCTACACCCCAAGGTGAGCTGTAAGACTGGCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAAGCAGAAAGG
GAAGCCAGGCTCTTTAATGTTCCAAGTCAGCTGTGCCTCACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGACTTTGTATC
TGTGCAGCATTTTATGGAAATCACTGGTGACCTATAGGATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTGGATTCTAGG
TGGACATTACAGAGTTGAATTCCTCACTACCCCCTCCCGCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTGTACAAAAAG
TCTGTTTCCTGCTGAGCCAATAGTGATTTGTTTGCATATCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAATTATATTTT
AGAAAATACTTTGTGAGGCCGGGCATGGTGGCAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAAT
ATAAGGATGTAAAAGAAGCAATTTGCTTGCACATCTGAATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAGCAATTTGAC
TTTTATTTTTGTTTTTCTAAAGAACAGCTAGGTGAAAGGAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCCCCACCATGG
TGTTTCATGAAACATCCCCACCACCTGAAGTGATCTTTTTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAAACATGTTTT
TAAATAATCTACAAATGAGAACCCAAATAGTAGTGTTTTGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATGCAAAATTTC
AGGACAGTTAATTTGGACTTCCCTTACCCTAAGAGGGTTTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTAAGAGACAAA
ACCTTCAGGTACATAATGCATGAAAATCTTTAAATGCCTGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATTAGCCAATGC
CCTAAAAGCATCTAACAATTTAAGGTTATCTTATGAGTCCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTACCAACGCCA
TGTTTACGTGACAAGAAATTGTTTTGGCCCTGTGGTTTATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTTCAAAGAGAA
CCATTTACAATTGGAATTTCCACCTGTGTGGCTGTTTGCAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTATAATTAGTTT
GATCACTTTGTCTTGTTTTTCAGTGTCTACAATTATAGCTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGCGCGGTGGCT
CATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACC
CCGTCTCTACTAAAAATACAAAAAAATTAGTCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATG
GCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAA
AAAAAAAAAAAAAAAAAAAAAAAGACTAAAATTTGATTTAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAAAAAAAAAAA
AAAAGGAATCATGTCATCTTGACCCAGCTGACTGGAAATTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGGGCAACAGAG
TGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAATTGCTACAT
GGGGGAGCTGCTGGTGTTGTTGAGGTCCTTGGGAGCATTCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCAGCTTCATAT
ACCCAGATATGGACACTTCTACACGTGAAATTCAAACTGAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAGTATGAAACC
TTGACATTGCTGAAAGAAAAGTGGAAACTGTAAGGGACAACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAGAGCAGCTAA
GGAGAAGACAGATCATTCAAGAACTTAAGTCGTTTGTTAGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTTGGAGGAAAG
CTAAGCAGGTTCTGACCACCCATTTTCATGTACTTTAAATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAATTCAGCTAAT
TACTACCTGATTTCAAAGGCAGCTAGTGTAGAAGACTGGTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAATCAAGAAAT
TCAGTTACAGGCTGCAAGTGACCTAAAATTCCCCTACTCTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTCACTGCTCTG
CATACAGTTCCTTTTCAACCCTTACAAGACCTGCTTCATTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTCATTGGTAAC
TTAAATATTCACAAAATTGTCATAAAGCTTCTGAAACATCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATTTGCAGAATT
AACTCTAAAGTTGCAGCAACCATATTTATTAGAGAAATCTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGAGATCATCTG
TGCCTAAAAGAAAATGATAAAAATGTGTCATAATATCAAAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCCAAATTCAGG
CTGCGTTGTATGGCCTGCAAGGTAAGAATGGTTATTTTATTTTATTTTATTCTTTATATATATATATATATATTTATTTATTTTTTTGAG
ACAGAGTCTCTCTCTGTCACCCACGCTGGAGTGCAGTGGCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAAGCGATTCTC
CTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACATGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGTAGAGCTGGG
TTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATTCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGAGCTACCGTG
CCCAGCTGGTTTTTACATTTTAAAAACGTTTAGAGAAAGAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAAAATGTTTAC
TCTCTGGCTTGGGAGTTTGTCTCCCCTGCTCTAGACTGTCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAACTGCACTTCT
CTGCAAGGTGATTCTAGTGTGCACTTGTCAGAATGAAAATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATCACATGATTT
GTATTTAATATTTACATGACCTAATTATTTTTTCACGTCAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAACCTTTGAGA
AAAATTACTATGAGCAAGGTCCATGATTTAGTTTTCAATATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCTAGTTGCCCT
CAGCTTTTGAGTTGACTTCCAGAAAGTTGAGATCTTTTGACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGTTGTCAAGCT
GTGGTAGTCATGTACACTTTTTTTCTTTTTTTTAACTTTCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCGCTTCTTTTG
GATTTTTCTTTTTAGAGCTAAATTATTCATACCAATGAATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTTTGCTTAATG
GACTCATGTGGCATTGTTCACTATCATGCCTTTCCATACTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATAAACTGTTCA
AGCTAATACAGCATTTCCTAACTTCATAGTTGTCGCAGATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTACTGAATCTTA
CTAGCAACTAACTATTTTCAGGTAATCTCAGTCTGCTTATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTTCTAGAAAAT
AGTAGGATAATGTATTTTTTCCTGTCTGCTATAATGGAGACTATATTTCTGCATTCATTACCTCTCATAGGTGAAAATATTAAATTAAAT

>In-frame_ENST00000395851_ENST00000532485_TCGA-AR-A2LJ-01A_NCOR1_chr17_15995177_-_ACER3_chr11_76637601_length(amino acids)=1262AA_start in transcript=20_stop in transcript=3808
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVND
SISAETAEQMDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSD
NDSSATCSADEDVDGEPERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKA
MHESALLEEQRQRQEQIDLECRSSTSPCGTSKSPNREWEGNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLK
YEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLG
YTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLR

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Fusion Gene PPI Analysis for NCOR1-ACER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246254_3121005.33333333333342441.0SIN3A/B
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145254_3121021.33333333333342338.0SIN3A/B
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461_3731005.33333333333342441.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451_3731021.33333333333342338.0ZBTB33 and HEXIM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-22461501_24401005.33333333333342441.0C1D
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191501_24400915.0C1D
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-21451501_24401021.33333333333342338.0C1D
HgeneNCOR1chr17:15995177chr11:76637601ENST00000268712-2246988_18161005.33333333333342441.0ETO
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119988_18160915.0ETO
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395851-2145988_18161021.33333333333342338.0ETO
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-119254_3120915.0SIN3A/B
HgeneNCOR1chr17:15995177chr11:76637601ENST00000395848-1191_3730915.0ZBTB33 and HEXIM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR1-ACER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR1-ACER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0006142Malignant neoplasm of breast1CGI;CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOR1C0269102Endometrioma1CTD_human
HgeneNCOR1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNCOR1C0345904Malignant neoplasm of liver1CTD_human
HgeneNCOR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNCOR1C0678222Breast Carcinoma1CGI;CTD_human
HgeneNCOR1C0857007Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
HgeneNCOR1C1565885Direct Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1565886Indirect Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1621958Glioblastoma Multiforme1CTD_human
HgeneNCOR1C4704874Mammary Carcinoma, Human1CTD_human
TgeneACER3C4540358LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET2ORPHANET;UNIPROT
TgeneACER3C0025202melanoma1CTD_human