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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR1-TFDP2 (FusionGDB2 ID:57504)

Fusion Gene Summary for NCOR1-TFDP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1-TFDP2
Fusion gene ID: 57504
HgeneTgene
Gene symbol

NCOR1

TFDP2

Gene ID

9611

7029

Gene namenuclear receptor corepressor 1transcription factor Dp-2
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRDP2
Cytomap

17p12-p11.2

3q23

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1transcription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2)
Modification date2020031320200313
UniProtAcc

O75376

.
Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 		ENST00000499676, 
ENST00000489671, ENST00000486111, 
ENST00000477292, ENST00000495310, 
ENST00000467072, ENST00000317104, 
ENST00000310282, ENST00000479040, 
ENST00000397991, ENST00000464782, 
Fusion gene scores* DoF score30 X 30 X 13=117008 X 7 X 5=280
# samples 339
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND TFDP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR1(15960828)-TFDP2(141693033), # samples:3
Anticipated loss of major functional domain due to fusion event.NCOR1-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR1-TFDP2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
NCOR1-TFDP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768

TgeneTFDP2

GO:0045892

negative regulation of transcription, DNA-templated

20176812

TgeneTFDP2

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TFDP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A9ZI-01ANCOR1chr17

15960828

-TFDP2chr3

141693033

-
ChimerDB4PRADTCGA-V1-A9ZINCOR1chr17

15960828

-TFDP2chr3

141693033

-
ChimerDB4PRADTCGA-V1-A9ZI-01ANCOR1chr17

15960828

-TFDP2chr3

141693033

-


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Fusion Gene ORF analysis for NCOR1-TFDP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000268712ENST00000499676NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000489671NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000486111NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000477292NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000495310NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000467072NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000317104NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000310282NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000479040NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000268712ENST00000397991NCOR1chr17

15960828

-TFDP2chr3

141693033

-
5CDS-intronENST00000268712ENST00000464782NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000499676NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000489671NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000486111NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000477292NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000495310NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000467072NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000317104NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000310282NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000479040NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395851ENST00000397991NCOR1chr17

15960828

-TFDP2chr3

141693033

-
5CDS-intronENST00000395851ENST00000464782NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000499676NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000489671NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000486111NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000477292NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000495310NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000467072NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000317104NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000310282NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000479040NCOR1chr17

15960828

-TFDP2chr3

141693033

-
Frame-shiftENST00000395857ENST00000397991NCOR1chr17

15960828

-TFDP2chr3

141693033

-
5CDS-intronENST00000395857ENST00000464782NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000499676NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000489671NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000486111NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000477292NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000495310NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000467072NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000317104NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000310282NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000479040NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000395848ENST00000397991NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-intronENST00000395848ENST00000464782NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000499676NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000489671NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000486111NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000477292NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000495310NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000467072NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000317104NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000310282NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000479040NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-3CDSENST00000583226ENST00000397991NCOR1chr17

15960828

-TFDP2chr3

141693033

-
intron-intronENST00000583226ENST00000464782NCOR1chr17

15960828

-TFDP2chr3

141693033

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NCOR1-TFDP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCOR1-TFDP2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

.
FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NCOR1-TFDP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NCOR1-TFDP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR1-TFDP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR1-TFDP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0006142Malignant neoplasm of breast1CGI;CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOR1C0269102Endometrioma1CTD_human
HgeneNCOR1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNCOR1C0345904Malignant neoplasm of liver1CTD_human
HgeneNCOR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNCOR1C0678222Breast Carcinoma1CGI;CTD_human
HgeneNCOR1C0857007Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
HgeneNCOR1C1565885Direct Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1565886Indirect Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1621958Glioblastoma Multiforme1CTD_human
HgeneNCOR1C4704874Mammary Carcinoma, Human1CTD_human
TgeneTFDP2C0345967Malignant mesothelioma1CTD_human