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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDRG1-ST3GAL1 (FusionGDB2 ID:57633)

Fusion Gene Summary for NDRG1-ST3GAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG1-ST3GAL1
Fusion gene ID: 57633
HgeneTgene
Gene symbol

NDRG1

ST3GAL1

Gene ID

10397

6482

Gene nameN-myc downstream regulated 1ST3 beta-galactoside alpha-2,3-sialyltransferase 1
SynonymsCAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5Gal-NAc6S|SIAT4A|SIATFL|ST3GalA|ST3GalA.1|ST3GalIA|ST3GalIA,1|ST3O
Cytomap

8q24.22

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive proteinCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-AST3GalIalpha 2,3-ST 1beta-galactoside alpha-2,3-sialyltransferase 1sialyltransferase 4A (beta-galactosidase alpha-2,3-sialy
Modification date2020032820200313
UniProtAcc

Q92597

.
Ensembl transtripts involved in fusion geneENST00000323851, ENST00000354944, 
ENST00000521414, ENST00000537882, 
ENST00000414097, ENST00000518176, 
ENST00000522476, ENST00000518066, 
ENST00000399640, ENST00000319914, 
ENST00000521180, ENST00000522652, 
ENST00000519435, 
Fusion gene scores* DoF score27 X 21 X 12=680412 X 15 X 5=900
# samples 4015
** MAII scorelog2(40/6804*10)=-4.08831123588866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDRG1 [Title/Abstract] AND ST3GAL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDRG1(134296492)-ST3GAL1(134488843), # samples:3
ST3GAL1(134583936)-NDRG1(134296572), # samples:2
Anticipated loss of major functional domain due to fusion event.NDRG1-ST3GAL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NDRG1-ST3GAL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NDRG1-ST3GAL1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ST3GAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1OC-01ANDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
ChimerDB4CESCTCGA-DS-A1OC-01ANDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
ChimerDB4KIRCTCGA-B0-5400-01ANDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
ChimerDB4KIRCTCGA-B4-5838-01ANDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
ChimerDB4KIRCTCGA-BP-4160-01ANDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
ChimerDB4KIRCTCGA-B0-5400-01ANDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
ChimerDB4CESCTCGA-DS-A1OC-01ANDRG1chr8

134292475

-ST3GAL1chr8

134475702

-


Top

Fusion Gene ORF analysis for NDRG1-ST3GAL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323851ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000323851ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000323851ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000323851ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5CDS-intronENST00000323851ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000354944ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000354944ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000354944ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000354944ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5CDS-intronENST00000354944ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000521414ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000521414ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000521414ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000521414ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-intronENST00000521414ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5UTR-3CDSENST00000537882ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5UTR-3CDSENST00000537882ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5UTR-3CDSENST00000537882ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5UTR-3CDSENST00000537882ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5UTR-intronENST00000537882ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000414097ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000414097ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000414097ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000414097ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
5CDS-intronENST00000414097ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518176ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518176ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518176ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518176ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-intronENST00000518176ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000522476ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000522476ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000522476ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000522476ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-intronENST00000522476ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518066ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518066ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518066ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-3CDSENST00000518066ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
intron-intronENST00000518066ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134475705

-
Frame-shiftENST00000323851ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000323851ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000323851ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000323851ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5CDS-intronENST00000323851ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000354944ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000354944ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000354944ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000354944ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5CDS-intronENST00000354944ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000521414ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000521414ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000521414ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000521414ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-intronENST00000521414ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5UTR-3CDSENST00000537882ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5UTR-3CDSENST00000537882ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5UTR-3CDSENST00000537882ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5UTR-3CDSENST00000537882ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5UTR-intronENST00000537882ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000414097ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000414097ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000414097ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
Frame-shiftENST00000414097ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
5CDS-intronENST00000414097ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518176ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518176ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518176ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518176ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-intronENST00000518176ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000522476ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000522476ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000522476ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000522476ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-intronENST00000522476ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518066ENST00000399640NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518066ENST00000319914NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518066ENST00000521180NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-3CDSENST00000518066ENST00000522652NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
intron-intronENST00000518066ENST00000519435NDRG1chr8

134292475

-ST3GAL1chr8

134475702

-
In-frameENST00000323851ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000323851ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000323851ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000323851ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000323851ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
In-frameENST00000354944ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000354944ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000354944ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000354944ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000354944ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-3CDSENST00000521414ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000521414ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000521414ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000521414ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000521414ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5UTR-3CDSENST00000537882ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5UTR-5UTRENST00000537882ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5UTR-5UTRENST00000537882ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5UTR-5UTRENST00000537882ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5UTR-5UTRENST00000537882ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
Frame-shiftENST00000414097ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000414097ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000414097ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000414097ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-5UTRENST00000414097ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-3CDSENST00000518176ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518176ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518176ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518176ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518176ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-3CDSENST00000522476ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000522476ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000522476ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000522476ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000522476ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-3CDSENST00000518066ENST00000399640NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518066ENST00000319914NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518066ENST00000521180NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518066ENST00000522652NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
intron-5UTRENST00000518066ENST00000519435NDRG1chr8

134296492

-ST3GAL1chr8

134488843

-
5CDS-intronENST00000323851ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-intronENST00000323851ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000323851ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000323851ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000323851ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-intronENST00000354944ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-intronENST00000354944ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000354944ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000354944ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000354944ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000521414ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000521414ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000521414ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000521414ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000521414ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5UTR-intronENST00000537882ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5UTR-intronENST00000537882ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5UTR-5UTRENST00000537882ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5UTR-5UTRENST00000537882ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5UTR-5UTRENST00000537882ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-intronENST00000414097ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-intronENST00000414097ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000414097ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000414097ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
5CDS-5UTRENST00000414097ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000518176ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000518176ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518176ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518176ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518176ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000522476ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000522476ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000522476ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000522476ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000522476ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000518066ENST00000399640NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-intronENST00000518066ENST00000319914NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518066ENST00000521180NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518066ENST00000522652NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-
intron-5UTRENST00000518066ENST00000519435NDRG1chr8

134292478

-ST3GAL1chr8

134511435

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323851NDRG1chr8134296492-ENST00000399640ST3GAL1chr8134488843-65011855621584340
ENST00000354944NDRG1chr8134296492-ENST00000399640ST3GAL1chr8134488843-65162005771599340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323851ENST00000399640NDRG1chr8134296492-ST3GAL1chr8134488843-0.0021419890.997858
ENST00000354944ENST00000399640NDRG1chr8134296492-ST3GAL1chr8134488843-0.0021803330.99781966

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Fusion Genomic Features for NDRG1-ST3GAL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDRG1-ST3GAL1


check button Go to

FGviewer for the breakpoints of chr8:134296492-chr8:134488843

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG1

Q92597

.
FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneST3GAL1chr8:134296492chr8:134488843ENST00000319914291_130341.0Topological domainCytoplasmic
TgeneST3GAL1chr8:134296492chr8:134488843ENST000003199142935_3400341.0Topological domainLumenal
TgeneST3GAL1chr8:134296492chr8:134488843ENST00000399640-171_130341.0Topological domainCytoplasmic
TgeneST3GAL1chr8:134296492chr8:134488843ENST00000399640-1735_3400341.0Topological domainLumenal
TgeneST3GAL1chr8:134296492chr8:134488843ENST00000521180291_130341.0Topological domainCytoplasmic
TgeneST3GAL1chr8:134296492chr8:134488843ENST000005211802935_3400341.0Topological domainLumenal
TgeneST3GAL1chr8:134296492chr8:134488843ENST000005226522101_130341.0Topological domainCytoplasmic
TgeneST3GAL1chr8:134296492chr8:134488843ENST0000052265221035_3400341.0Topological domainLumenal
TgeneST3GAL1chr8:134296492chr8:134488843ENST000003199142914_340341.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneST3GAL1chr8:134296492chr8:134488843ENST00000399640-1714_340341.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneST3GAL1chr8:134296492chr8:134488843ENST000005211802914_340341.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneST3GAL1chr8:134296492chr8:134488843ENST0000052265221014_340341.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDRG1chr8:134296492chr8:134488843ENST00000323851-216339_36821.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296492chr8:134488843ENST00000414097-216339_36821.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296492chr8:134488843ENST00000522476-114339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296492chr8:134488843ENST00000537882-215339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
HgeneNDRG1chr8:134296492chr8:134488843ENST00000323851-216339_34821.0395.0RepeatNote=1
HgeneNDRG1chr8:134296492chr8:134488843ENST00000323851-216349_35821.0395.0RepeatNote=2
HgeneNDRG1chr8:134296492chr8:134488843ENST00000323851-216359_36821.0395.0RepeatNote=3
HgeneNDRG1chr8:134296492chr8:134488843ENST00000414097-216339_34821.0395.0RepeatNote=1
HgeneNDRG1chr8:134296492chr8:134488843ENST00000414097-216349_35821.0395.0RepeatNote=2
HgeneNDRG1chr8:134296492chr8:134488843ENST00000414097-216359_36821.0395.0RepeatNote=3
HgeneNDRG1chr8:134296492chr8:134488843ENST00000522476-114339_3480329.0RepeatNote=1
HgeneNDRG1chr8:134296492chr8:134488843ENST00000522476-114349_3580329.0RepeatNote=2
HgeneNDRG1chr8:134296492chr8:134488843ENST00000522476-114359_3680329.0RepeatNote=3
HgeneNDRG1chr8:134296492chr8:134488843ENST00000537882-215339_3480314.0RepeatNote=1
HgeneNDRG1chr8:134296492chr8:134488843ENST00000537882-215349_3580314.0RepeatNote=2
HgeneNDRG1chr8:134296492chr8:134488843ENST00000537882-215359_3680314.0RepeatNote=3


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Fusion Gene Sequence for NDRG1-ST3GAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000323851_ENST00000399640_TCGA-B0-5400-01A_NDRG1_chr8_134296492_-_ST3GAL1_chr8_134488843_length(transcript)=6501nt_BP=185nt
CCCAGCTGGTGCTGAAGCTCGTCAGTTCACCATCCGCCCTCGGCTTCCGCGGGGCGCTGGGCCGCCAGCCTCGGCACCGTCCTTTCCTTT
CTCCCTCGCGTTAGGCAGGTGACAGCAGGGACATGTCTCGGGAGATGCAGGATGTAGACCTCGCTGAGGTGAAGCCTTTGGTGGAGAAAG
GGGAGGCAGATGACAGACAACCTTCTGTGCCTTCATCAAGCTGGTTGTGTACCCACCATGTCCCTGGCGACAGGATGGGAAAGAAAAAGC
CCTAATTAAGGATCGTCAGAAACCACAGTTGGAGGAGGACGGCAGAGACAGTTTCCCTCCCCGCTATACCAACACCCTTCCTTCGAGGTC
CTCGCTCCTGAGGGACCCTGGACTGTCACAGAGATTAATGACCCCTTATCTTCTTTGGATGTGAAAGGAAATCACTGGTTAAAGCTTGAT
CGAGAGACATTATCAGCTCTTTAAGGATTGCAGAAGAATAGGCTACTTTATTTTCTGAAAAGGAGGGAGTTCCTGCTACCCATCGTGGGA
GGCCACCATCAGGACTGCGAAGATGGTGACCCTGCGGAAGAGGACCCTGAAAGTGCTCACCTTCCTCGTGCTCTTCATCTTCCTCACCTC
CTTCTTCCTGAACTACTCCCACACCATGGTGGCCACCACCTGGTTCCCCAAGCAGATGGTCCTGGAGCTCTCCGAGAACCTGAAGAGACT
GATCAAGCACAGGCCTTGCACCTGCACCCACTGCATCGGGCAGCGCAAGCTCTCGGCCTGGTTCGATGAGAGGTTCAACCAGACCATGCA
GCCGCTGCTGACCGCCCAGAACGCGCTCTTGGAGGACGACACCTACCGATGGTGGCTGAGGCTCCAGCGGGAGAAGAAGCCCAATAACTT
GAATGACACCATCAAGGAGCTGTTCAGAGTGGTGCCTGGGAATGTGGACCCTATGCTGGAGAAGAGGTCGGTGGGCTGCCGGCGCTGCGC
CGTTGTGGGCAACTCGGGCAACCTGAGGGAGTCTTCTTATGGGCCTGAGATAGACAGTCACGACTTTGTCCTCAGGATGAACAAGGCGCC
CACGGCAGGGTTTGAAGCTGATGTTGGGACCAAGACCACCCACCATCTGGTGTACCCTGAGAGCTTCCGGGAGCTGGGAGATAATGTCAG
CATGATCCTGGTGCCCTTCAAGACCATCGACTTGGAGTGGGTGGTGAGCGCCATCACCACGGGCACCATTTCCCACACCTACATCCCGGT
TCCTGCAAAGATCAGAGTGAAACAGGATAAGATCCTGATCTACCACCCAGCCTTCATCAAGTATGTCTTTGACAACTGGCTGCAAGGGCA
CGGGCGATACCCATCTACCGGCATCCTCTCGGTCATCTTCTCAATGCATGTCTGCGATGAGGTGGACTTGTACGGCTTCGGGGCAGACAG
CAAAGGGAACTGGCACCACTACTGGGAGAACAACCCATCCGCGGGGGCTTTTCGCAAGACGGGGGTGCACGATGCAGACTTTGAGTCTAA
CGTGACGGCCACCTTGGCCTCCATCAATAAAATCCGGATCTTCAAGGGGAGATGACGCAGTGAAGGGCTGAGGATGGACGCACTGTCACA
CCTCTGCATTTCCAGCCCCAGCATCTTGCTGGAGCCGTTCCATCCCGGAGCTTGGAGGGGCAGCCTCAGGTGTGTGCCTGGGCACCGCTC
ACAGCCTCTTGCACCCAGCCGTTGGCAGCATCTACTCAGCAAGGTCACTAAGCTCTGCCAGCGTGGCAGAGCATGTCTTGGAACCTGTCT
TGAGTGGGGACAACGTCCCCCCACTGCTGCCCTAGAGCTGGGGAGACGCTGGGAAAGGTTCAACCTCCACACACTAAAATCATTTTGGCT
CCTGGGGCAAGCTTGGGGAATGAATGTGGAAGATGCCTATATTCTGAGAGACAGGACAGTTTCCCAGGAAGATGGGCAGAGACTTGAGTG
GCGATTACCTCCAGCACAGAGACGTGCCAGGCGGTGTTGGCGCTCGGGGCGAGATGCTGCCCTTCTTTGCACGAAGCCTGGCCTCTTGCT
TGGCGTGATAACCCTGTCATCTTCCCAAAGCTCATTTATGAGCCACCAGAGGCTCCTACCCCAAAGATTTTCACAGAAACTTGAGGCCAG
GTGCCGTGGCTCACACCTGTAATCTGAACACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCA
ACATAGTGAGACTCCTGTCTCTACAAAAATAAAAGATTTAAAAAAATTAGCCAGGCACGGTGGCACACACTTGTAGCCCCAGCTACTAGG
GAGGCTGAGGAGGGAGGATCTCTTGTGCCTAGGAGTTCGAGGCTGCAGTGGGCTGTGATCACACCACTGCACTCCAGCCTGGGCAACAGA
GTGAGACCCTGTCTCTGAAAAAAAAAAAAAAAGAAAAGAAAAAAAACCCCAAACTTGGCACCGTGTTTCTGACTCCTGCAGATGCCTCTT
CCCAAGCAGTTGTTCCTTTGAGTAGTCAGTCTCATGGTTCTAATCGTGGCGAGAGCGGATCTGACCACTTCCATGTGCCTTTGTATTTGG
GAAAGAAAAGCATGCATTGGCTGAAATGAAACAAAAGCCCTTACTTGGGAAAAGGGACCCCCACCAGCGGCCCTGCTTGCTCCGTAGCTG
GGAACATCTTTTCTGGTTTCCTGAGCCAGCACCTGAATTGCAACGAAGCTCTGAGGATACTCAACACCACCCAGCAGTGCGTCAGAATGG
AACGTACATTCTCATTCTCAGACTGTTCAATATGGTGCCCGTAACCTCCAAAGCCACACAGGAGGCTGCCAGCAGCATTTTCCCCAAGGG
CCTGAGCTCAGGGTCAAGTCCCTGCTGGCCATCTTGGGGCTGTCACTGGGGGTCTGGGTCAAGGACATCCCAGGAATGGTAACTGCCACA
TACCTCATCTTCTTACTCCCCAGCTACTCTCTTTTCCTCATTAGCCTTCCTGATTATTTATTGATTTCTTTTTTTTATTCAACTGACATT
GTTTGCACCCTGGCTCTGTTGGTGGTCCTGGTGTTTTAATGAAGCTTGCCTCACCCAGTAGCTGGGAAATTAGGTGGGGGTGCTTAAGGG
AGGTTTGTAGGAGTCCTCGGACGTGGGATATTGGGGGTATCTAGGGCTTGGATGGTTTGTGGAATGTCCTCAGCATCCTCCCGTCCCAAC
CCAACCTTCCTTCTTCCTCATTGTGGACTTGGATTTATTCTCAGGCTAGGAGTCTCCAAAACTCCGTGAAACCTTATTGCTGCTGGGTGT
GGAGTGGAGAGTGACAGGAATGTGGGGGACGGTGATTGTTGGCTCCAGTTACTAATGTTTAAGCAGAAAAACCACTTTCTTGTTGAAAAT
ATCCCTGAAAAGGTCGCTGCTGCTTTGAGGAGGCGTGACTTTTTCCTGGTGGAGTGTGACGGAGGCATGGGGCCTGTGCTCCCAGGCTCG
GGGGAGCCCCCTCTGCACACGGGGAGGGAGGAACTTGGGGACATCAGTCATGGGTCACAGGTGGCTTCAGGCCATTCACAAGAGTCCCCG
GAAGTTGCGTGCCAAGTTTGGTTTTTTCCCTGAATCTCTGCATATGAGCATTTTTCTGGAGAAAGGACCATAGCTTTTATTAGATTCTCA
AAGGTTCAGAATGGGGAATGTGTTAAACAAACCGAAAACCTGTTTCAGCTTTAAAATCCTCCAAAACTTTAAAGACTTTTCTTTTTTCTG
AGAAAGGCTGGTAAATCACTGAGTCATCATTCAGAACATACAGCCTCGAAGGGCAGAGCTCACACCCATATATGACGTTAAGAGCTCAAC
AAATGTTTGTTGAGTGACTGAGTGACCCCAGGGGCAGACTCCAGATCATCAGACACTGATACAGAGAGCGATGCTATCTCCTCAACTCTC
CCTCTTCTCCTAAAAGCTGAGTCTATATAGGGATGACAGGCTCAGGCTGAGCAGTCGACTTCTCTGGGTTTTGCTGTGTAAGAATAGGTC
CCTCAACATGAAGATGTGTCTGCGTCTGAGCCAGATGCTGCCTGGGTCGGTTGCCTGGCCTCCGTCTGGTCTCCCTCCCTCCTACTAGGG
TGGTCAAGCTGTGAGATCTCTTCCAGCCTCCAAATCCAGCTTTCCCATTTTACTGATGAGAAAATCAAGGCCACATTGCAGCTGGGTGGG
GAGTGGAGCGTGACAGGCACGGGAGAGGACAGCGATTGTTGACTCTAGTTCCTGATGTTTAATCAGAAAAACCACTTTTCCTGTAGAGCA
CATTTCCTAAAAGGCTGCTGCTGTGTAGGGAGGTGTGGCCTTTTCCTGGTGCAGTGTGAAGGAGGGAAGTGACGGGCAGTCGTGAACTGT
CTGGGACAGATAGCACAAGTCAGAGTTTGAGCAAAACTAGGGTGTTACCGGCGCTATGTTGAAATTGTCTGGAGGCGGGCTTTCCCAGCG
AGTCTCCATTCAGCATCTGGAAAAAGTGTAACCAGAATGGAGGTGTCTGACTCTCCTGTGCTCTCTCAGCGCCGAGCTCTAGCTGCAGGC
TGCCTGGGTGGCCTTCTCACACCCTCCCGTGCAGGAGACTGCATTTCTCTTTCCCACAGCCCAGCAGATAGCTCATTGGCTTAGCAATGG
GCACTTAACAGAATCCAGTTGTTGCAGCCAGAATTAAATGCACCAGTCTGGCTTAAACCAACTGGAACTCATCCCTGGGGTGAAGGTGGC
TGGGAATTAGACAAGAGTGTGTGTTAGCCAAAAGGCACATGCATGCTGTCAGCAGGAGAATGAGGAGCACTGGTTCTGGGCAGGCAGTGG
CAGGGGCTCCCTCAGGCCCCTGATTCCCAGCCCACAGCTCTTTCTACTCTGCAGACAGAGTTCCTTGGAGACTGGCCCTGCATTCAGGCA
GGGAGCAGAGGGGTCCCTGCCTGCAGCACCCAGAGCTGAACCTGAAGCTACAAAGATGGGCTGATGAGGTGGCCCATGAGGTGTCAGCAA
CATCCCAACCCCCTGGGTCTCCCCAGTGAGTCAGGGCACTGATTTGCTATAGCTGGAGCTACATGCACCTCTCCTCCCCTCAGCCACCTT
TTAGGGGAGAAAGGAGGGCAGATTTGTAACCTCTGGTTCTCTGCAGGGATCCTGGGCTGGAAGAAAGTTCATAAATGGATGAATGCCTTT
TAAAACTCCAGCTTTTCCAAGCATCATTCACCAAAGCATTTGGTTAGGCTTAGAGAGAAAAGCTGGATATGAGAAAATAGAATGTAAAAT
AGGAGGGAAAAAAAAAAAGAAGGTGGAGAGGGCAGTTAAGATCTGGGTGATTCTTTAGGGAAACGGCTGGTTGAGAGGCTTTGATGGAAT
CCCATTCTCTGCTGTGGCCAGAAGGTGGTGCTAGAGGCCAGTCCCACTTGGATGTGACCCTGGCCTCTGCCAGGATTCAAACCACAAAGA
ACATTTGGAACTGGGATGTTTGCTTTGAAGCAGCCCGAAAACAAGTGAAAGGAAACCAAGATAACTCTCTCTCCCTCCGCTGGCAAGGAT
CAAAAATACCTTGTGCAGGGAAGCCCGAGCCTCGAGGGGCCACTGCCCAGCTAAAGATGACTGGACACCAGCCATGCACCATCAGGAACC
AGCACCTGTCCTCACCCCTGAGAAGAGCCCCGGGGGTATCATTATATCCATCGCAGACATCTGGTTTGCAGCAAATGTGGCTACACGCCA
TCAGGATTATCCTGCCCTGTGGACTGGGCTAGCTAGTTTTGAGATAGAGTCAACCTCCCCATTTTTGTTTGTCATGAAAACACCAGCTCC
TGCACCCCTGGGGTGCTACCTGACACCTGTGCAAAGAAAAGGAGGAAAACTTAGAAGAAAAGGCAGAGACAGGCAAGACAGCATCTCACA
GCTTGTCAGGATCAGGGCATTACCGACTATTTTTTCTTACCAAAAGAGCACTGAATTTCCTAGGGGAAGGTGAGCCACCTTTACACCTCC
TGTCCTCCCTCCCAGCCCGTCAAGCGATCCCATCACCCAGCCTCATCACTCAGCTTCTTCCTAGTACAAAACTGCCATCGGTTGTACGTC
CTGAGCTGTGGGACGTCAGCTTTAACCCTAGCCTGTCTCAGGGCCTCGCCCTCCAGCCCCCCGCCCCTTAGGGTGATCGTGGGTTTCTTC
CCTTCCTCCTGCACAATCGCTTCCCTTCACTGAATTCCCTTCAAAGCCAAAGTTTCTTGAGCACTTTTTCTTGTGTGCAGTCTTGTGTGT
TTGGGTGTTGGTGTTTTTAAATTTGCTTTCTATTCCCCCCTGCCTCTCTCCATGTCGTTACGCAGCTGAGCACTGGTTGGGATGCATTCG
AATGACTTCAGCAAGATCCTGCTTTCCTCAGCCCCCGCTCTGTTTTATTTATTGTTTAATATTTCCAATGATCCAAATCAAAGTGAATAA

>In-frame_ENST00000323851_ENST00000399640_TCGA-B0-5400-01A_NDRG1_chr8_134296492_-_ST3GAL1_chr8_134488843_length(amino acids)=340AA_start in transcript=562_stop in transcript=1584
MVTLRKRTLKVLTFLVLFIFLTSFFLNYSHTMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQN
ALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEAD
VGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTG

--------------------------------------------------------------
>In-frame_ENST00000354944_ENST00000399640_TCGA-B0-5400-01A_NDRG1_chr8_134296492_-_ST3GAL1_chr8_134488843_length(transcript)=6516nt_BP=200nt
AAACCTCGCCTGGCTCCCAGCTGGTGCTGAAGCTCGTCAGTTCACCATCCGCCCTCGGCTTCCGCGGGGCGCTGGGCCGCCAGCCTCGGC
ACCGTCCTTTCCTTTCTCCCTCGCGTTAGGCAGGTGACAGCAGGGACATGTCTCGGGAGATGCAGGATGTAGACCTCGCTGAGGTGAAGC
CTTTGGTGGAGAAAGGGGAGGCAGATGACAGACAACCTTCTGTGCCTTCATCAAGCTGGTTGTGTACCCACCATGTCCCTGGCGACAGGA
TGGGAAAGAAAAAGCCCTAATTAAGGATCGTCAGAAACCACAGTTGGAGGAGGACGGCAGAGACAGTTTCCCTCCCCGCTATACCAACAC
CCTTCCTTCGAGGTCCTCGCTCCTGAGGGACCCTGGACTGTCACAGAGATTAATGACCCCTTATCTTCTTTGGATGTGAAAGGAAATCAC
TGGTTAAAGCTTGATCGAGAGACATTATCAGCTCTTTAAGGATTGCAGAAGAATAGGCTACTTTATTTTCTGAAAAGGAGGGAGTTCCTG
CTACCCATCGTGGGAGGCCACCATCAGGACTGCGAAGATGGTGACCCTGCGGAAGAGGACCCTGAAAGTGCTCACCTTCCTCGTGCTCTT
CATCTTCCTCACCTCCTTCTTCCTGAACTACTCCCACACCATGGTGGCCACCACCTGGTTCCCCAAGCAGATGGTCCTGGAGCTCTCCGA
GAACCTGAAGAGACTGATCAAGCACAGGCCTTGCACCTGCACCCACTGCATCGGGCAGCGCAAGCTCTCGGCCTGGTTCGATGAGAGGTT
CAACCAGACCATGCAGCCGCTGCTGACCGCCCAGAACGCGCTCTTGGAGGACGACACCTACCGATGGTGGCTGAGGCTCCAGCGGGAGAA
GAAGCCCAATAACTTGAATGACACCATCAAGGAGCTGTTCAGAGTGGTGCCTGGGAATGTGGACCCTATGCTGGAGAAGAGGTCGGTGGG
CTGCCGGCGCTGCGCCGTTGTGGGCAACTCGGGCAACCTGAGGGAGTCTTCTTATGGGCCTGAGATAGACAGTCACGACTTTGTCCTCAG
GATGAACAAGGCGCCCACGGCAGGGTTTGAAGCTGATGTTGGGACCAAGACCACCCACCATCTGGTGTACCCTGAGAGCTTCCGGGAGCT
GGGAGATAATGTCAGCATGATCCTGGTGCCCTTCAAGACCATCGACTTGGAGTGGGTGGTGAGCGCCATCACCACGGGCACCATTTCCCA
CACCTACATCCCGGTTCCTGCAAAGATCAGAGTGAAACAGGATAAGATCCTGATCTACCACCCAGCCTTCATCAAGTATGTCTTTGACAA
CTGGCTGCAAGGGCACGGGCGATACCCATCTACCGGCATCCTCTCGGTCATCTTCTCAATGCATGTCTGCGATGAGGTGGACTTGTACGG
CTTCGGGGCAGACAGCAAAGGGAACTGGCACCACTACTGGGAGAACAACCCATCCGCGGGGGCTTTTCGCAAGACGGGGGTGCACGATGC
AGACTTTGAGTCTAACGTGACGGCCACCTTGGCCTCCATCAATAAAATCCGGATCTTCAAGGGGAGATGACGCAGTGAAGGGCTGAGGAT
GGACGCACTGTCACACCTCTGCATTTCCAGCCCCAGCATCTTGCTGGAGCCGTTCCATCCCGGAGCTTGGAGGGGCAGCCTCAGGTGTGT
GCCTGGGCACCGCTCACAGCCTCTTGCACCCAGCCGTTGGCAGCATCTACTCAGCAAGGTCACTAAGCTCTGCCAGCGTGGCAGAGCATG
TCTTGGAACCTGTCTTGAGTGGGGACAACGTCCCCCCACTGCTGCCCTAGAGCTGGGGAGACGCTGGGAAAGGTTCAACCTCCACACACT
AAAATCATTTTGGCTCCTGGGGCAAGCTTGGGGAATGAATGTGGAAGATGCCTATATTCTGAGAGACAGGACAGTTTCCCAGGAAGATGG
GCAGAGACTTGAGTGGCGATTACCTCCAGCACAGAGACGTGCCAGGCGGTGTTGGCGCTCGGGGCGAGATGCTGCCCTTCTTTGCACGAA
GCCTGGCCTCTTGCTTGGCGTGATAACCCTGTCATCTTCCCAAAGCTCATTTATGAGCCACCAGAGGCTCCTACCCCAAAGATTTTCACA
GAAACTTGAGGCCAGGTGCCGTGGCTCACACCTGTAATCTGAACACTTTGGGAGGCCGAGGCGGGAGGATCACTTGAGCCCAGGAGTTCA
AGACCAGCCTGGGCAACATAGTGAGACTCCTGTCTCTACAAAAATAAAAGATTTAAAAAAATTAGCCAGGCACGGTGGCACACACTTGTA
GCCCCAGCTACTAGGGAGGCTGAGGAGGGAGGATCTCTTGTGCCTAGGAGTTCGAGGCTGCAGTGGGCTGTGATCACACCACTGCACTCC
AGCCTGGGCAACAGAGTGAGACCCTGTCTCTGAAAAAAAAAAAAAAAGAAAAGAAAAAAAACCCCAAACTTGGCACCGTGTTTCTGACTC
CTGCAGATGCCTCTTCCCAAGCAGTTGTTCCTTTGAGTAGTCAGTCTCATGGTTCTAATCGTGGCGAGAGCGGATCTGACCACTTCCATG
TGCCTTTGTATTTGGGAAAGAAAAGCATGCATTGGCTGAAATGAAACAAAAGCCCTTACTTGGGAAAAGGGACCCCCACCAGCGGCCCTG
CTTGCTCCGTAGCTGGGAACATCTTTTCTGGTTTCCTGAGCCAGCACCTGAATTGCAACGAAGCTCTGAGGATACTCAACACCACCCAGC
AGTGCGTCAGAATGGAACGTACATTCTCATTCTCAGACTGTTCAATATGGTGCCCGTAACCTCCAAAGCCACACAGGAGGCTGCCAGCAG
CATTTTCCCCAAGGGCCTGAGCTCAGGGTCAAGTCCCTGCTGGCCATCTTGGGGCTGTCACTGGGGGTCTGGGTCAAGGACATCCCAGGA
ATGGTAACTGCCACATACCTCATCTTCTTACTCCCCAGCTACTCTCTTTTCCTCATTAGCCTTCCTGATTATTTATTGATTTCTTTTTTT
TATTCAACTGACATTGTTTGCACCCTGGCTCTGTTGGTGGTCCTGGTGTTTTAATGAAGCTTGCCTCACCCAGTAGCTGGGAAATTAGGT
GGGGGTGCTTAAGGGAGGTTTGTAGGAGTCCTCGGACGTGGGATATTGGGGGTATCTAGGGCTTGGATGGTTTGTGGAATGTCCTCAGCA
TCCTCCCGTCCCAACCCAACCTTCCTTCTTCCTCATTGTGGACTTGGATTTATTCTCAGGCTAGGAGTCTCCAAAACTCCGTGAAACCTT
ATTGCTGCTGGGTGTGGAGTGGAGAGTGACAGGAATGTGGGGGACGGTGATTGTTGGCTCCAGTTACTAATGTTTAAGCAGAAAAACCAC
TTTCTTGTTGAAAATATCCCTGAAAAGGTCGCTGCTGCTTTGAGGAGGCGTGACTTTTTCCTGGTGGAGTGTGACGGAGGCATGGGGCCT
GTGCTCCCAGGCTCGGGGGAGCCCCCTCTGCACACGGGGAGGGAGGAACTTGGGGACATCAGTCATGGGTCACAGGTGGCTTCAGGCCAT
TCACAAGAGTCCCCGGAAGTTGCGTGCCAAGTTTGGTTTTTTCCCTGAATCTCTGCATATGAGCATTTTTCTGGAGAAAGGACCATAGCT
TTTATTAGATTCTCAAAGGTTCAGAATGGGGAATGTGTTAAACAAACCGAAAACCTGTTTCAGCTTTAAAATCCTCCAAAACTTTAAAGA
CTTTTCTTTTTTCTGAGAAAGGCTGGTAAATCACTGAGTCATCATTCAGAACATACAGCCTCGAAGGGCAGAGCTCACACCCATATATGA
CGTTAAGAGCTCAACAAATGTTTGTTGAGTGACTGAGTGACCCCAGGGGCAGACTCCAGATCATCAGACACTGATACAGAGAGCGATGCT
ATCTCCTCAACTCTCCCTCTTCTCCTAAAAGCTGAGTCTATATAGGGATGACAGGCTCAGGCTGAGCAGTCGACTTCTCTGGGTTTTGCT
GTGTAAGAATAGGTCCCTCAACATGAAGATGTGTCTGCGTCTGAGCCAGATGCTGCCTGGGTCGGTTGCCTGGCCTCCGTCTGGTCTCCC
TCCCTCCTACTAGGGTGGTCAAGCTGTGAGATCTCTTCCAGCCTCCAAATCCAGCTTTCCCATTTTACTGATGAGAAAATCAAGGCCACA
TTGCAGCTGGGTGGGGAGTGGAGCGTGACAGGCACGGGAGAGGACAGCGATTGTTGACTCTAGTTCCTGATGTTTAATCAGAAAAACCAC
TTTTCCTGTAGAGCACATTTCCTAAAAGGCTGCTGCTGTGTAGGGAGGTGTGGCCTTTTCCTGGTGCAGTGTGAAGGAGGGAAGTGACGG
GCAGTCGTGAACTGTCTGGGACAGATAGCACAAGTCAGAGTTTGAGCAAAACTAGGGTGTTACCGGCGCTATGTTGAAATTGTCTGGAGG
CGGGCTTTCCCAGCGAGTCTCCATTCAGCATCTGGAAAAAGTGTAACCAGAATGGAGGTGTCTGACTCTCCTGTGCTCTCTCAGCGCCGA
GCTCTAGCTGCAGGCTGCCTGGGTGGCCTTCTCACACCCTCCCGTGCAGGAGACTGCATTTCTCTTTCCCACAGCCCAGCAGATAGCTCA
TTGGCTTAGCAATGGGCACTTAACAGAATCCAGTTGTTGCAGCCAGAATTAAATGCACCAGTCTGGCTTAAACCAACTGGAACTCATCCC
TGGGGTGAAGGTGGCTGGGAATTAGACAAGAGTGTGTGTTAGCCAAAAGGCACATGCATGCTGTCAGCAGGAGAATGAGGAGCACTGGTT
CTGGGCAGGCAGTGGCAGGGGCTCCCTCAGGCCCCTGATTCCCAGCCCACAGCTCTTTCTACTCTGCAGACAGAGTTCCTTGGAGACTGG
CCCTGCATTCAGGCAGGGAGCAGAGGGGTCCCTGCCTGCAGCACCCAGAGCTGAACCTGAAGCTACAAAGATGGGCTGATGAGGTGGCCC
ATGAGGTGTCAGCAACATCCCAACCCCCTGGGTCTCCCCAGTGAGTCAGGGCACTGATTTGCTATAGCTGGAGCTACATGCACCTCTCCT
CCCCTCAGCCACCTTTTAGGGGAGAAAGGAGGGCAGATTTGTAACCTCTGGTTCTCTGCAGGGATCCTGGGCTGGAAGAAAGTTCATAAA
TGGATGAATGCCTTTTAAAACTCCAGCTTTTCCAAGCATCATTCACCAAAGCATTTGGTTAGGCTTAGAGAGAAAAGCTGGATATGAGAA
AATAGAATGTAAAATAGGAGGGAAAAAAAAAAAGAAGGTGGAGAGGGCAGTTAAGATCTGGGTGATTCTTTAGGGAAACGGCTGGTTGAG
AGGCTTTGATGGAATCCCATTCTCTGCTGTGGCCAGAAGGTGGTGCTAGAGGCCAGTCCCACTTGGATGTGACCCTGGCCTCTGCCAGGA
TTCAAACCACAAAGAACATTTGGAACTGGGATGTTTGCTTTGAAGCAGCCCGAAAACAAGTGAAAGGAAACCAAGATAACTCTCTCTCCC
TCCGCTGGCAAGGATCAAAAATACCTTGTGCAGGGAAGCCCGAGCCTCGAGGGGCCACTGCCCAGCTAAAGATGACTGGACACCAGCCAT
GCACCATCAGGAACCAGCACCTGTCCTCACCCCTGAGAAGAGCCCCGGGGGTATCATTATATCCATCGCAGACATCTGGTTTGCAGCAAA
TGTGGCTACACGCCATCAGGATTATCCTGCCCTGTGGACTGGGCTAGCTAGTTTTGAGATAGAGTCAACCTCCCCATTTTTGTTTGTCAT
GAAAACACCAGCTCCTGCACCCCTGGGGTGCTACCTGACACCTGTGCAAAGAAAAGGAGGAAAACTTAGAAGAAAAGGCAGAGACAGGCA
AGACAGCATCTCACAGCTTGTCAGGATCAGGGCATTACCGACTATTTTTTCTTACCAAAAGAGCACTGAATTTCCTAGGGGAAGGTGAGC
CACCTTTACACCTCCTGTCCTCCCTCCCAGCCCGTCAAGCGATCCCATCACCCAGCCTCATCACTCAGCTTCTTCCTAGTACAAAACTGC
CATCGGTTGTACGTCCTGAGCTGTGGGACGTCAGCTTTAACCCTAGCCTGTCTCAGGGCCTCGCCCTCCAGCCCCCCGCCCCTTAGGGTG
ATCGTGGGTTTCTTCCCTTCCTCCTGCACAATCGCTTCCCTTCACTGAATTCCCTTCAAAGCCAAAGTTTCTTGAGCACTTTTTCTTGTG
TGCAGTCTTGTGTGTTTGGGTGTTGGTGTTTTTAAATTTGCTTTCTATTCCCCCCTGCCTCTCTCCATGTCGTTACGCAGCTGAGCACTG
GTTGGGATGCATTCGAATGACTTCAGCAAGATCCTGCTTTCCTCAGCCCCCGCTCTGTTTTATTTATTGTTTAATATTTCCAATGATCCA

>In-frame_ENST00000354944_ENST00000399640_TCGA-B0-5400-01A_NDRG1_chr8_134296492_-_ST3GAL1_chr8_134488843_length(amino acids)=340AA_start in transcript=577_stop in transcript=1599
MVTLRKRTLKVLTFLVLFIFLTSFFLNYSHTMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQN
ALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEAD
VGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTG

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Fusion Gene PPI Analysis for NDRG1-ST3GAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDRG1-ST3GAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDRG1-ST3GAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDRG1C0027627Neoplasm Metastasis2CTD_human
HgeneNDRG1C1832334CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNDRG1C0004114Astrocytoma1CTD_human
HgeneNDRG1C0006142Malignant neoplasm of breast1CTD_human
HgeneNDRG1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNDRG1C0007134Renal Cell Carcinoma1CTD_human
HgeneNDRG1C0017636Glioblastoma1CTD_human
HgeneNDRG1C0022665Kidney Neoplasm1CTD_human
HgeneNDRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNDRG1C0023903Liver neoplasms1CTD_human
HgeneNDRG1C0025202melanoma1CTD_human
HgeneNDRG1C0026640Mouth Neoplasms1CTD_human
HgeneNDRG1C0029295Oropharyngeal Neoplasms1CTD_human
HgeneNDRG1C0033578Prostatic Neoplasms1CTD_human
HgeneNDRG1C0149925Small cell carcinoma of lung1CTD_human
HgeneNDRG1C0153381Malignant neoplasm of mouth1CTD_human
HgeneNDRG1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNDRG1C0206658Smooth Muscle Tumor1CTD_human
HgeneNDRG1C0206734Hemangioblastoma1CTD_human
HgeneNDRG1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneNDRG1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNDRG1C0280785Diffuse Astrocytoma1CTD_human
HgeneNDRG1C0334579Anaplastic astrocytoma1CTD_human
HgeneNDRG1C0334580Protoplasmic astrocytoma1CTD_human
HgeneNDRG1C0334581Gemistocytic astrocytoma1CTD_human
HgeneNDRG1C0334582Fibrillary Astrocytoma1CTD_human
HgeneNDRG1C0334583Pilocytic Astrocytoma1CTD_human
HgeneNDRG1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNDRG1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNDRG1C0345904Malignant neoplasm of liver1CTD_human
HgeneNDRG1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNDRG1C0547065Mixed oligoastrocytoma1CTD_human
HgeneNDRG1C0678222Breast Carcinoma1CTD_human
HgeneNDRG1C0740457Malignant neoplasm of kidney1CTD_human
HgeneNDRG1C0750935Cerebral Astrocytoma1CTD_human
HgeneNDRG1C0750936Intracranial Astrocytoma1CTD_human
HgeneNDRG1C0751692Multiple Hemangioblastomas1CTD_human
HgeneNDRG1C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNDRG1C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneNDRG1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNDRG1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneNDRG1C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneNDRG1C1458155Mammary Neoplasms1CTD_human
HgeneNDRG1C1621958Glioblastoma Multiforme1CTD_human
HgeneNDRG1C1704230Grade I Astrocytoma1CTD_human
HgeneNDRG1C2349952Oropharyngeal Carcinoma1CTD_human
HgeneNDRG1C4704874Mammary Carcinoma, Human1CTD_human
TgeneST3GAL1C0005586Bipolar Disorder1PSYGENET
TgeneST3GAL1C0014378Enterovirus Infections1CTD_human
TgeneST3GAL1C0033975Psychotic Disorders1PSYGENET
TgeneST3GAL1C0036341Schizophrenia1PSYGENET
TgeneST3GAL1C0349204Nonorganic psychosis1PSYGENET