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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDRG2-RPL38 (FusionGDB2 ID:57652)

Fusion Gene Summary for NDRG2-RPL38

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG2-RPL38
Fusion gene ID: 57652
HgeneTgene
Gene symbol

NDRG2

RPL38

Gene ID

57447

6169

Gene nameNDRG family member 2ribosomal protein L38
SynonymsSYLDL38
Cytomap

14q11.2

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 protein60S ribosomal protein L38large ribosomal subunit protein eL38
Modification date2020031320200313
UniProtAcc

Q9UN36

.
Ensembl transtripts involved in fusion geneENST00000403829, ENST00000298687, 
ENST00000350792, ENST00000397858, 
ENST00000554104, ENST00000555158, 
ENST00000553503, ENST00000397853, 
ENST00000360463, ENST00000556147, 
ENST00000397856, ENST00000397855, 
ENST00000554143, ENST00000397851, 
ENST00000397847, ENST00000298684, 
ENST00000397844, ENST00000554277, 
ENST00000439590, ENST00000311111, 
ENST00000584577, ENST00000534490, 
ENST00000533498, 
Fusion gene scores* DoF score17 X 14 X 3=71413 X 12 X 3=468
# samples 1813
** MAII scorelog2(18/714*10)=-1.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDRG2 [Title/Abstract] AND RPL38 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDRG2(21486161)-RPL38(72200288), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL38

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across NDRG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPL38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACK004088NDRG2chr14

21486161

-RPL38chr17

72200288

+


Top

Fusion Gene ORF analysis for NDRG2-RPL38

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000403829ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NDRG2-RPL38


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDRG2-RPL38


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG2

Q9UN36

.
FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NDRG2-RPL38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NDRG2-RPL38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDRG2-RPL38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDRG2-RPL38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDRG2C0007102Malignant tumor of colon1CTD_human
HgeneNDRG2C0007787Transient Ischemic Attack1CTD_human
HgeneNDRG2C0009375Colonic Neoplasms1CTD_human
HgeneNDRG2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNDRG2C0086543Cataract1CTD_human
HgeneNDRG2C0472381Posterior Circulation Transient Ischemic Attack1CTD_human
HgeneNDRG2C0524524Pseudoaphakia1CTD_human
HgeneNDRG2C0751019Carotid Circulation Transient Ischemic Attack1CTD_human
HgeneNDRG2C0751020Transient Ischemic Attack, Vertebrobasilar Circulation1CTD_human
HgeneNDRG2C0751021Crescendo Transient Ischemic Attacks1CTD_human
HgeneNDRG2C0751022Brain Stem Ischemia, Transient1CTD_human
HgeneNDRG2C0917805Transient Cerebral Ischemia1CTD_human
HgeneNDRG2C1510497Lens Opacities1CTD_human
HgeneNDRG2C1527335Transient Ischemic Attack, Anterior Circulation1CTD_human