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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDRG2-SEC63 (FusionGDB2 ID:57653)

Fusion Gene Summary for NDRG2-SEC63

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG2-SEC63
Fusion gene ID: 57653
HgeneTgene
Gene symbol

NDRG2

SEC63

Gene ID

57447

11231

Gene nameNDRG family member 2SEC63 homolog, protein translocation regulator
SynonymsSYLDDNAJC23|ERdj2|PCLD2|PRO2507|SEC63L
Cytomap

14q11.2

6q21

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 proteintranslocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like protein
Modification date2020031320200313
UniProtAcc

Q9UN36

.
Ensembl transtripts involved in fusion geneENST00000403829, ENST00000298687, 
ENST00000350792, ENST00000397858, 
ENST00000554104, ENST00000555158, 
ENST00000553503, ENST00000397853, 
ENST00000360463, ENST00000556147, 
ENST00000397856, ENST00000397855, 
ENST00000554143, ENST00000397851, 
ENST00000397847, ENST00000298684, 
ENST00000397844, ENST00000554277, 
ENST00000369002, ENST00000460009, 
Fusion gene scores* DoF score17 X 14 X 3=71438 X 14 X 15=7980
# samples 1839
** MAII scorelog2(18/714*10)=-1.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/7980*10)=-4.3548427173601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDRG2 [Title/Abstract] AND SEC63 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDRG2(21484932)-SEC63(108214782), # samples:1
Anticipated loss of major functional domain due to fusion event.NDRG2-SEC63 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NDRG2-SEC63 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDRG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SEC63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7478-01ANDRG2chr14

21484932

-SEC63chr6

108214782

-


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Fusion Gene ORF analysis for NDRG2-SEC63

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000403829ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000403829ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000298687ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000298687ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000350792ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000350792ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000397858ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000397858ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
In-frameENST00000554104ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000554104ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000555158ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000555158ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
In-frameENST00000553503ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000553503ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
In-frameENST00000397853ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000397853ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000360463ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000360463ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000556147ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000556147ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000397856ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000397856ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000397855ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000397855ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000554143ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000554143ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000397851ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000397851ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
Frame-shiftENST00000397847ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
5CDS-intronENST00000397847ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000298684ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000298684ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000397844ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000397844ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-3CDSENST00000554277ENST00000369002NDRG2chr14

21484932

-SEC63chr6

108214782

-
intron-intronENST00000554277ENST00000460009NDRG2chr14

21484932

-SEC63chr6

108214782

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000554104NDRG2chr1421484932-ENST00000369002SEC63chr6108214782-680021463171321334
ENST00000553503NDRG2chr1421484932-ENST00000369002SEC63chr6108214782-681621622341337367
ENST00000397853NDRG2chr1421484932-ENST00000369002SEC63chr6108214782-673320791091254381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000554104ENST00000369002NDRG2chr1421484932-SEC63chr6108214782-0.0005363820.9994636
ENST00000553503ENST00000369002NDRG2chr1421484932-SEC63chr6108214782-0.0001542790.99984574
ENST00000397853ENST00000369002NDRG2chr1421484932-SEC63chr6108214782-0.0002695870.9997304

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Fusion Genomic Features for NDRG2-SEC63


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDRG2-SEC63


check button Go to

FGviewer for the breakpoints of chr14:21484932-chr6:108214782

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG2

Q9UN36

.
FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021597_6350761.0Coiled coilOntology_term=ECO:0000255
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021734_7600761.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021104_1650761.0DomainJ
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021197_5410761.0DomainNote=SEC63 1
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021637_7140761.0DomainNote=SEC63 2
TgeneSEC63chr14:21484932chr6:108214782ENST000003690020211_140761.0Topological domainLumenal
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021210_7600761.0Topological domainCytoplasmic
TgeneSEC63chr14:21484932chr6:108214782ENST0000036900202136_690761.0Topological domainCytoplasmic
TgeneSEC63chr14:21484932chr6:108214782ENST0000036900202191_1880761.0Topological domainLumenal
TgeneSEC63chr14:21484932chr6:108214782ENST0000036900202115_350761.0TransmembraneHelical
TgeneSEC63chr14:21484932chr6:108214782ENST00000369002021189_2090761.0TransmembraneHelical
TgeneSEC63chr14:21484932chr6:108214782ENST0000036900202170_900761.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NDRG2-SEC63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000554104_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(transcript)=6800nt_BP=2146nt
CTCTTCCCCAGTAGAAGGATGGCCTCTGCTTGGCCCTCTCTTCTCTCTTTGCTTTCTTTCCTTCTATTCTAGTCCTTTCCCTTCCCTATC
TCTCCCCTCTCCTTCCTTCCCCTCCTCTTCTCTCTCTAATCTTCATTATTCTTTCTTATCCTCAAACTCATCTTCCGGTATCATGTTTTC
CTCAATTCTTGCTGATCCTGTTTTTAATTCTTTGTTCCCTTTTCCCTCTTGCCCACCCACTCCCAGCTCCCTGACCTTGGTGTTGCTCCT
TTTCTGGCCTCGTCTCCTCTGAGCCTAGCTCTTGGTGCCCTGTTTTCCTGCAGACTCACTCTGTGGAGACACCATACGGCTCTGTCACTT
TCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCAC
TGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGT
TCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATTTCTCTACAATAATTG
GAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTGTCCTCATCAACATTG
ATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTT
TCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAAT
TGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAG
GAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTCAAGATGGCTGACTCCG
GAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACCGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTACATGGCCTCATCCTGCA
TGACTCGCCTGTCCCGGTCTCGTACAGCCTCTCTGACCAGTGCAGCATCCGTTGATGGCAACCGGTCCCGCTCTCGCACCCTGTCCCAGA
GCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGGCCCTTGTTGCCCTAGAGTGGGACC
CAGCCCTCACCTCCCCCAGAGCTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCACCGTAAGCAAGGGAAAAAGGGCAGATCATGCGGGG
AGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTTTAACCCGTGATTCCCCCCAGCTCCTGGAAGAGATGTCCTAATATCTCTT
AGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGATGTTAAGGTGGAGAGGGCATATGCATCCTCTGTCCTGATCTAGGTGTCT
ATAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCCTGGTGCCTCCATCAGACTCTCCCTACTTGTCCCATATTTGCAAGGGGAGGGGATTT
GGGGCTGGGGCTCCATTCACCAAAGCTGAGGTGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCTACGTGAATGTGTGTCA
GGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGTGTAAAAAGGAAGTTGGAATGGGAGTTGGCGGGCAG
TGAACGAGTGTGGGGAAGGATTGGTGCTGGGGCAACAGGAAGGGGCCTGGGGCCGTTTGGCTGCACTAACTTTGGTAGCTCAGTGTGCAT
CTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTGCTTGGGGCTTGGCATAGGGTGGAAAGGGCTACCCTGGGGCTCTGACCA
CACTGTAGTATGTGTGGAGGGTGCCCTCCCGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGAGGAATCTGATTGGAAGTTCATGA
GGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAG
CTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGC
TGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATA
TAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCAT
CTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTA
AAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACAT
CGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCAT
AGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTT
CCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATC
AATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAA
ACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGT
AAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAA
TGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTG
CTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGT
AAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTA
TAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTA
AAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAAT
GGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGT
GAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTC
AAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAG
TGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCT
AGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGC
TGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCA
CCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAG
TGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTC
CACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTT
TCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATT
ATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTG
TATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTA
AACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAG
CTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGG
CGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTC
AGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTT
TGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAG
TGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTT
TTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCT
CTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCC
AGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGT
AGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCAT
TACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTT
TTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGT
TGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACT
TGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTG
ACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATT
ATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATT
TATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAG
ATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCA
GACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGA
GAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGA
AGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTC
TGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTAC

>In-frame_ENST00000554104_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(amino acids)=334AA_start in transcript=317_stop in transcript=1321
MQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADM
IPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKY
RNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAF

--------------------------------------------------------------
>In-frame_ENST00000553503_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(transcript)=6816nt_BP=2162nt
GGCGGCAGCAGGTAGGGGGAGGGGCAGGCGAGGGGCCGTAGGGCCTGGAAGGCGCCAGCCGGGCCGGCGGGCGGTGTGATTGATCCGCGT
CCCCTGGAGCTGGAGGCTCGGGGGAAAGGGCCAGCACGGAGCGGGCGCTCGGTTGCTGCGCACAAAGGCTGAGGCTCCAAGAGCTGCAGG
GCGTGTTTGGGACCCCAGAGTCAGAAGGAGTGAGAACCCTGACCCCTAATCCCACTGCATCCAGCCAATAGGAGCCCAGCCACCATGGCG
GAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGACTCACTCTGTGGAGACACCA
TACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAA
TCTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAA
GAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAAT
TTCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTT
GTCCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATG
ATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAAC
CTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCT
GTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTCGTTCCTC
AAGATGGCTGACTCCGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACCGAGGCCTTCAAGTACTTCCTGCAAGGCATGGGCTAC
ATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACAGCCTCTCTGACCAGTGCAGCATCCGTTGATGGCAACCGGTCCCGCTCT
CGCACCCTGTCCCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGGCCCTTGTT
GCCCTAGAGTGGGACCCAGCCCTCACCTCCCCCAGAGCTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCACCGTAAGCAAGGGAAAAAG
GGCAGATCATGCGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTTTAACCCGTGATTCCCCCCAGCTCCTGGAAGAGA
TGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGATGTTAAGGTGGAGAGGGCATATGCATCCTCTGT
CCTGATCTAGGTGTCTATAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCCTGGTGCCTCCATCAGACTCTCCCTACTTGTCCCATATTTG
CAAGGGGAGGGGATTTGGGGCTGGGGCTCCATTCACCAAAGCTGAGGTGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTATGGACCT
ACGTGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGTGTAAAAAGGAAGTTGGAAT
GGGAGTTGGCGGGCAGTGAACGAGTGTGGGGAAGGATTGGTGCTGGGGCAACAGGAAGGGGCCTGGGGCCGTTTGGCTGCACTAACTTTG
GTAGCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTGCTTGGGGCTTGGCATAGGGTGGAAAGGGCTAC
CCTGGGGCTCTGACCACACTGTAGTATGTGTGGAGGGTGCCCTCCCGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGAGGAATCT
GATTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTG
AGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACAT
ATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTG
AAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGAT
GGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTAT
GGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAAT
ATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATA
CAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGC
TACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACC
TCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGG
TGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGA
GCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGAC
TCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATA
GTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTG
GAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACA
TAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGC
AACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAAT
TAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCT
CAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAG
GGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAA
GCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGT
AGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATA
AGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAA
AAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAA
AATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCA
GCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTG
AGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAA
TTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCA
AAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTC
CTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCT
GCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTC
TGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTG
ACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAG
CACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATC
AAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTA
TTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCT
TTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACT
GCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAA
TTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCT
CCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCT
TTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTT
AAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATT
CTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACC
CAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGG
AAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATT
GTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGT
ATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTG
CAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAA
GCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAG
TAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATG
GTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCT

>In-frame_ENST00000553503_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(amino acids)=367AA_start in transcript=234_stop in transcript=1337
MHPANRSPATMAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQN
FVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAH
KLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVEC
NSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPG

--------------------------------------------------------------
>In-frame_ENST00000397853_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(transcript)=6733nt_BP=2079nt
AAGCCCGAGCCGGGGCGGGCCCGAGTCAAAGGCAAGTGAAGGTGGAAGCGGCCGCGGCGGCAGCAGACCCCAGAGTCAGAAGGAGTGAGA
ACCCTGACCCCTAATCCCACTGCATCCAGCCAATAGGAGCCCAGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCC
ACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGGAGGCTGAGTTAGCTGCCCGAATCCTCCTGGACCAGGGACAGACTCACTCTGTGGA
GACACCATACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAA
CTATAAATCTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGG
AATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTA
CCTAAATTTCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGA
AGGTCTTGTCCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCC
GGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGC
ACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAG
GTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGGAATGTAACTCAAAACTGGACCCCACCCAGACCTC
GTTCCTCAAGATGGCTGACTCCGGAGGTCAGCCCCAGCTGACTCAGCCAGGCAAGCTGACCGAGGCCTTCAAGTACTTCCTGCAAGGCAT
GGGCTACATGGCCTCATCCTGCATGACTCGCCTGTCCCGGTCTCGTACAGCCTCTCTGACCAGTGCAGCATCCGTTGATGGCAACCGGTC
CCGCTCTCGCACCCTGTCCCAGAGCAGCGAGTCTGGAACTCTTTCTTCGGGGCCCCCGGGGCACACCATGGAGGTCTCCTGTTGAATGGC
CCTTGTTGCCCTAGAGTGGGACCCAGCCCTCACCTCCCCCAGAGCTAACCTGGGAGGTGCTGAAGGGGCATTGGGCCACCGTAAGCAAGG
GAAAAAGGGCAGATCATGCGGGGAGATGACCTTGATCTTTGATTGCTACCCTAACCTTGACCTTTAACCCGTGATTCCCCCCAGCTCCTG
GAAGAGATGTCCTAATATCTCTTAGGGACCCAGACCCCTAAATTCTCCTCCTCCCCCATTTTGATGTTAAGGTGGAGAGGGCATATGCAT
CCTCTGTCCTGATCTAGGTGTCTATAGCTGAGGGGTAAGAGGTTGTTGTAGTTGTCCTGGTGCCTCCATCAGACTCTCCCTACTTGTCCC
ATATTTGCAAGGGGAGGGGATTTGGGGCTGGGGCTCCATTCACCAAAGCTGAGGTGGCTTCTCATTAACCCTTTAGGACTCTGAAGGGTA
TGGACCTACGTGAATGTGTGTCAGGGGGAGACTTGCTGGTGGGTTAGTGGTCCTCAGGATGTGATAGAAACATCCAGTGTAAAAAGGAAG
TTGGAATGGGAGTTGGCGGGCAGTGAACGAGTGTGGGGAAGGATTGGTGCTGGGGCAACAGGAAGGGGCCTGGGGCCGTTTGGCTGCACT
AACTTTGGTAGCTCAGTGTGCATCTAGAGTGGGACTGGGGAGGGAGCTAAGCTTGGGCTGGGCTGCTTGGGGCTTGGCATAGGGTGGAAA
GGGCTACCCTGGGGCTCTGACCACACTGTAGTATGTGTGGAGGGTGCCCTCCCGTCTCCCACAACTTCTGCTATAACAATAAACTGTAGA
GGAATCTGATTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAG
GACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTT
TGCACATATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTT
ACTCTTGAAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGT
AGGGGATGGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATC
AGTCTATGGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACAC
CACAAATATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGC
AGTGATACAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATAT
AGAGGGCTACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTT
CTAAACCTCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTG
ATACTGGTGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCT
ATCAGGAGCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTT
TGTTGACTCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGA
TTGAATAGTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGT
ACAACTGGAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGA
GGAAACATAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAA
AATTTGCAACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATG
TGAAAATTAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCT
ATAACCTCAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAA
GTAGGAGGGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAG
GGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAAC
AATGTGTAGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGG
CTTTATAAGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAA
AAAAAAAAAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGT
AAAATAAAATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCT
CTCTCCAGCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGG
AAACTTGAGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGA
AGTGAAATTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCA
CAATTCAAAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGT
TCATGTCCTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAAT
ACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCT
CAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTT
ATTTTTGACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGT
AATTCAGCACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGG
AGCTATCAAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCC
TTGGCTATTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTG
CTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCA
GCTCACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACC
CAGCTAATTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCC
TCAGCCTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCA
TCATCCTTTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGA
CTGCCTTAAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACC
AAGCATTCTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCT
GAAAACCCAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCC
ATTGAGGAAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTG
TACAATTGTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAAT
TATCAGTATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTT
TACATTGCAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTA
CAACAAAGCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAA
GCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAA
GATGATGGTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAA

>In-frame_ENST00000397853_ENST00000369002_TCGA-HT-7478-01A_NDRG2_chr14_21484932_-_SEC63_chr6_108214782_length(amino acids)=381AA_start in transcript=109_stop in transcript=1254
MHPANRSPATMAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQ
PLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLIN
IDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLV
VGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NDRG2-SEC63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDRG2-SEC63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDRG2-SEC63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDRG2C0007102Malignant tumor of colon1CTD_human
HgeneNDRG2C0007787Transient Ischemic Attack1CTD_human
HgeneNDRG2C0009375Colonic Neoplasms1CTD_human
HgeneNDRG2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNDRG2C0086543Cataract1CTD_human
HgeneNDRG2C0472381Posterior Circulation Transient Ischemic Attack1CTD_human
HgeneNDRG2C0524524Pseudoaphakia1CTD_human
HgeneNDRG2C0751019Carotid Circulation Transient Ischemic Attack1CTD_human
HgeneNDRG2C0751020Transient Ischemic Attack, Vertebrobasilar Circulation1CTD_human
HgeneNDRG2C0751021Crescendo Transient Ischemic Attacks1CTD_human
HgeneNDRG2C0751022Brain Stem Ischemia, Transient1CTD_human
HgeneNDRG2C0917805Transient Cerebral Ischemia1CTD_human
HgeneNDRG2C1510497Lens Opacities1CTD_human
HgeneNDRG2C1527335Transient Ischemic Attack, Anterior Circulation1CTD_human
TgeneSEC63C0158683Polycystic liver disease2CTD_human;ORPHANET
TgeneSEC63C0022680Polycystic Kidney Diseases1CTD_human
TgeneSEC63C1567435Polycystic Kidney - body part1CTD_human
TgeneSEC63C4310769POLYCYSTIC LIVER DISEASE 2 WITH OR WITHOUT KIDNEY CYSTS1GENOMICS_ENGLAND