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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:APP-SEC63 (FusionGDB2 ID:5776) |
Fusion Gene Summary for APP-SEC63 |
Fusion gene summary |
Fusion gene information | Fusion gene name: APP-SEC63 | Fusion gene ID: 5776 | Hgene | Tgene | Gene symbol | APP | SEC63 | Gene ID | 351 | 11231 |
Gene name | amyloid beta precursor protein | SEC63 homolog, protein translocation regulator | |
Synonyms | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | DNAJC23|ERdj2|PCLD2|PRO2507|SEC63L | |
Cytomap | 21q21.3 | 6q21 | |
Type of gene | protein-coding | protein-coding | |
Description | amyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei | translocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like protein | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P05067 | . | |
Ensembl transtripts involved in fusion gene | ENST00000346798, ENST00000354192, ENST00000348990, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000448388, ENST00000440126, ENST00000439274, ENST00000474136, | ENST00000369002, ENST00000460009, | |
Fusion gene scores | * DoF score | 31 X 25 X 12=9300 | 38 X 14 X 15=7980 |
# samples | 33 | 39 | |
** MAII score | log2(33/9300*10)=-4.81669278663694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(39/7980*10)=-4.3548427173601 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APP [Title/Abstract] AND SEC63 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APP(27252862)-SEC63(108214782), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | APP-SEC63 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
Hgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
Hgene | APP | GO:1905606 | regulation of presynapse assembly | 19726636 |
Fusion gene breakpoints across APP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SEC63 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | THCA | TCGA-DJ-A13S-01A | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
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Fusion Gene ORF analysis for APP-SEC63 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000346798 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000346798 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
Frame-shift | ENST00000354192 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000354192 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
Frame-shift | ENST00000348990 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000348990 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
Frame-shift | ENST00000357903 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000357903 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
In-frame | ENST00000358918 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000358918 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
In-frame | ENST00000359726 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
5CDS-intron | ENST00000359726 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-3CDS | ENST00000448388 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-intron | ENST00000448388 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-3CDS | ENST00000440126 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-intron | ENST00000440126 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-3CDS | ENST00000439274 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-intron | ENST00000439274 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-3CDS | ENST00000474136 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
intron-intron | ENST00000474136 | ENST00000460009 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000358918 | APP | chr21 | 27252862 | - | ENST00000369002 | SEC63 | chr6 | 108214782 | - | 8232 | 3578 | 200 | 2458 | 752 |
ENST00000359726 | APP | chr21 | 27252862 | - | ENST00000369002 | SEC63 | chr6 | 108214782 | - | 8118 | 3464 | 200 | 2344 | 714 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000358918 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - | 0.000420623 | 0.99957937 |
ENST00000359726 | ENST00000369002 | APP | chr21 | 27252862 | - | SEC63 | chr6 | 108214782 | - | 0.000469041 | 0.99953103 |
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Fusion Genomic Features for APP-SEC63 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for APP-SEC63 |
Go to FGviewer for the breakpoints of chr21:27252862-chr6:108214782 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
APP | . |
FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 230_260 | 1144.3333333333333 | 771.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 274_280 | 1144.3333333333333 | 771.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 230_260 | 1069.3333333333333 | 696.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 274_280 | 1069.3333333333333 | 696.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 230_260 | 1013.3333333333334 | 640.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 274_280 | 1013.3333333333334 | 640.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 230_260 | 1125.3333333333333 | 752.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 274_280 | 1125.3333333333333 | 752.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 230_260 | 1126.0 | 753.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 274_280 | 1126.0 | 753.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 230_260 | 1088.0 | 715.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 274_280 | 1088.0 | 715.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 28_189 | 1144.3333333333333 | 771.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 374_565 | 1144.3333333333333 | 771.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 28_189 | 1069.3333333333333 | 696.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 374_565 | 1069.3333333333333 | 696.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 28_189 | 1013.3333333333334 | 640.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 374_565 | 1013.3333333333334 | 640.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 28_189 | 1125.3333333333333 | 752.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 374_565 | 1125.3333333333333 | 752.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 28_189 | 1126.0 | 753.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 374_565 | 1126.0 | 753.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 28_189 | 1088.0 | 715.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 374_565 | 1088.0 | 715.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 344_365 | 1144.3333333333333 | 771.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 724_734 | 1144.3333333333333 | 771.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 344_365 | 1069.3333333333333 | 696.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 724_734 | 1069.3333333333333 | 696.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 344_365 | 1013.3333333333334 | 640.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 724_734 | 1013.3333333333334 | 640.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 344_365 | 1125.3333333333333 | 752.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 724_734 | 1125.3333333333333 | 752.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 344_365 | 1126.0 | 753.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 724_734 | 1126.0 | 753.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 344_365 | 1088.0 | 715.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 724_734 | 1088.0 | 715.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 131_189 | 1144.3333333333333 | 771.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 181_188 | 1144.3333333333333 | 771.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 28_123 | 1144.3333333333333 | 771.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 391_423 | 1144.3333333333333 | 771.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 491_522 | 1144.3333333333333 | 771.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 523_540 | 1144.3333333333333 | 771.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 96_110 | 1144.3333333333333 | 771.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 131_189 | 1069.3333333333333 | 696.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 181_188 | 1069.3333333333333 | 696.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 28_123 | 1069.3333333333333 | 696.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 391_423 | 1069.3333333333333 | 696.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 491_522 | 1069.3333333333333 | 696.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 523_540 | 1069.3333333333333 | 696.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 96_110 | 1069.3333333333333 | 696.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 131_189 | 1013.3333333333334 | 640.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 181_188 | 1013.3333333333334 | 640.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 28_123 | 1013.3333333333334 | 640.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 391_423 | 1013.3333333333334 | 640.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 491_522 | 1013.3333333333334 | 640.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 523_540 | 1013.3333333333334 | 640.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 96_110 | 1013.3333333333334 | 640.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 131_189 | 1125.3333333333333 | 752.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 181_188 | 1125.3333333333333 | 752.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 28_123 | 1125.3333333333333 | 752.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 391_423 | 1125.3333333333333 | 752.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 491_522 | 1125.3333333333333 | 752.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 523_540 | 1125.3333333333333 | 752.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 96_110 | 1125.3333333333333 | 752.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 131_189 | 1126.0 | 753.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 181_188 | 1126.0 | 753.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 28_123 | 1126.0 | 753.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 391_423 | 1126.0 | 753.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 491_522 | 1126.0 | 753.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 523_540 | 1126.0 | 753.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 96_110 | 1126.0 | 753.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 131_189 | 1088.0 | 715.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 181_188 | 1088.0 | 715.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 28_123 | 1088.0 | 715.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 391_423 | 1088.0 | 715.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 491_522 | 1088.0 | 715.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 523_540 | 1088.0 | 715.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 96_110 | 1088.0 | 715.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 18_701 | 1144.3333333333333 | 771.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 723_770 | 1144.3333333333333 | 771.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 18_701 | 1069.3333333333333 | 696.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 723_770 | 1069.3333333333333 | 696.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 18_701 | 1013.3333333333334 | 640.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 723_770 | 1013.3333333333334 | 640.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 18_701 | 1125.3333333333333 | 752.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 723_770 | 1125.3333333333333 | 752.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 18_701 | 1126.0 | 753.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 723_770 | 1126.0 | 753.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 18_701 | 1088.0 | 715.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 723_770 | 1088.0 | 715.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 702_722 | 1144.3333333333333 | 771.0 | Transmembrane | Helical |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 702_722 | 1069.3333333333333 | 696.0 | Transmembrane | Helical |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 702_722 | 1013.3333333333334 | 640.0 | Transmembrane | Helical |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 702_722 | 1125.3333333333333 | 752.0 | Transmembrane | Helical |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 702_722 | 1126.0 | 753.0 | Transmembrane | Helical |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 702_722 | 1088.0 | 715.0 | Transmembrane | Helical |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 597_635 | 0 | 761.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 734_760 | 0 | 761.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 104_165 | 0 | 761.0 | Domain | J | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 197_541 | 0 | 761.0 | Domain | Note=SEC63 1 | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 637_714 | 0 | 761.0 | Domain | Note=SEC63 2 | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 1_14 | 0 | 761.0 | Topological domain | Lumenal | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 210_760 | 0 | 761.0 | Topological domain | Cytoplasmic | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 36_69 | 0 | 761.0 | Topological domain | Cytoplasmic | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 91_188 | 0 | 761.0 | Topological domain | Lumenal | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 15_35 | 0 | 761.0 | Transmembrane | Helical | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 189_209 | 0 | 761.0 | Transmembrane | Helical | |
Tgene | SEC63 | chr21:27252862 | chr6:108214782 | ENST00000369002 | 0 | 21 | 70_90 | 0 | 761.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 230_260 | 0 | 747.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 274_280 | 0 | 747.0 | Compositional bias | Note=Poly-Thr |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 28_189 | 0 | 747.0 | Domain | E1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 374_565 | 0 | 747.0 | Domain | E2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 344_365 | 0 | 747.0 | Motif | OX-2 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 724_734 | 0 | 747.0 | Motif | Note=Basolateral sorting signal |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 131_189 | 0 | 747.0 | Region | CuBD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 181_188 | 0 | 747.0 | Region | Note=Zinc-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 28_123 | 0 | 747.0 | Region | GFLD subdomain |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 391_423 | 0 | 747.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 491_522 | 0 | 747.0 | Region | Note=Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 523_540 | 0 | 747.0 | Region | Collagen-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 96_110 | 0 | 747.0 | Region | Heparin-binding |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 18_701 | 0 | 747.0 | Topological domain | Extracellular |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 723_770 | 0 | 747.0 | Topological domain | Cytoplasmic |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 702_722 | 0 | 747.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for APP-SEC63 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000358918_ENST00000369002_TCGA-DJ-A13S-01A_APP_chr21_27252862_-_SEC63_chr6_108214782_length(transcript)=8232nt_BP=3578nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAAC AAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGAT GTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCC AGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATG AGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCA TGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTT TTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGG ATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAA TCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTC ATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCT ACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGT GTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAG ATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTG TGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATA TTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCA GCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATT TTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTT CGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAG AATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTT TCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGG CAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACC AGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTC TTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCTTGGAAGTTCATGAGGCTAAGC CTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGG AAGAAGAGGAGGAAGAAGAAGATGATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGG AAGTGTATCATAAACCAGAAACAGTACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGG CAGTGGCGGTGCCTTGGTACAACCTGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAAT GATAATAAATCCTTTGTTATTATAACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCA GGAAACACAGTCTGTAAATGAGCGACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAG TTTAAGTAACATCGCTCAAGTTGATAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAA ACTTTTATTTTTACTTATCTTGGTCATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCT TAATTGCCCAGAGTTATCAGACAGATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGG ATCTAATTCTTTTGATAAGTTCTAGCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTT TAAAAAAGGTTCACTCTAAAAGCTGAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAA CATGCAAAGGAAGCTTTTTTTGTATTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGT GTCTTTTTACTATCAGGACATAAATAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTG ACTGCTATTTCTGTATACTGTAGAAAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTA GAGATGTGTACATGATGAATCATTGAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTG ATTGTAATAATTCTTTCCTATCAAAATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTG CCACTTTCAGTGCAGAATACTACCGGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTT TGGTTCTAAATTTAAGATGTAATATTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCT TTCTTGGCAGGCAGGAGGCAGTGTCACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGG TTCTGCTGTGAAGCACCAGTGTCTTGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGA GGGATTAGAGAAAACAGGTGTGGCACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCT TGAAAGATTTCAAGAAAAGTTGTTTTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCT CTGGTTTTAAGATTCTGGAGAGGATGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAA TTCCACCAGTTTGTTTTCCTTTTCTCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAG GTAACCTCTTTCCATATGGCAGTAGTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCC TTCGTTTTTCCTCTGGAATGAGAATAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTA TAAAGAAACTGACATTTTGTCAACAATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATA TTTTTCTCTAATTGGTAAAGTACCTATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAG CATTATAATATTTGATTGAGGCCCTGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTT TCATAATTTTTTTTTTAAGTTAGGGAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACT GAGGGCTGGAAAAGGACAGGCCTGTCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATG TCAAACAACTGATGTGGAAACAGGGAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCT TCAGCCAATCCAAACCATATACTAGAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGT TGTCATTCATCACATATTTACTGAGTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGA ACTCACTCGCTGGTGTTAGAGCAGGTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTT TTTAGTCTATCTACTGTAGGCAGAAGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCT TCTTAAGACGGAGTCTCGCTCTGTCCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAA GCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGG GATTTTGCCACGTTGTCCAGCCTGGTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCA TGAGCCACTGCGCCCAGCCTGTTGGGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTT TTAAGAAACAATTTTCCCACAAACGGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAAC CATAACATTTTGCCAGCTGTGTAGTGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTA GGGCTATTTTGCAAAACTTAAAAAGATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTT TAGGGCTATTGTTTCAGGTGGGGGTGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTAT TTAATCTCATCCTTTTAAATTTCTATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATTTATAAATA AACATTTATTGGTGCATTAAGTAGAGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACT CCTATATGGGTTTGGATCAGATTAAACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAA TATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTC TATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTT CAGATAAGGGCAGTGATTCTGAAGAAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAG AGCAAGATGAAAAACAAAACAAAGATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTACCACAGTCA >In-frame_ENST00000358918_ENST00000369002_TCGA-DJ-A13S-01A_APP_chr21_27252862_-_SEC63_chr6_108214782_length(amino acids)=752AA_start in transcript=200_stop in transcript=2458 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP ANTENEGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEV -------------------------------------------------------------- >In-frame_ENST00000359726_ENST00000369002_TCGA-DJ-A13S-01A_APP_chr21_27252862_-_SEC63_chr6_108214782_length(transcript)=8118nt_BP=3464nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG ATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAA ACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGC CGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGAC TGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAG GATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTG TTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACG CCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGA ACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGA AGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCAC ACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTA TCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAA TTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTC CTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACT GTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACAT TAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTT TTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATC ATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGAC TACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATAC AAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGT ATAAAATGGTGTTTTCATGTAAATAAATACATTCTTGGAGGAGCTTGGAAGTTCATGAGGCTAAGCCTGTGCCAGAAAATCACCCACAGT GGGATACAGCAATAGAGGGGGATGAAGACCAGGAGGACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATG ATGACTAAGCAGTACTCTGAATGGACCACAGTGTTTGCACATATTTGCAATTTTTTGCTGTTTTGGAAGTGTATCATAAACCAGAAACAG TACAGAACTGATGTTGAGGGAGGTGTAGTTTTTTTACTCTTGAAATGGGTGCATAATATAACTAGGCAGTGGCGGTGCCTTGGTACAACC TGAAAAATGTTAAGGCTTATTGAAACCTTTCAAGTAGGGGATGGTACATTTATTTCATCTGCAAATGATAATAAATCCTTTGTTATTATA ACTGTCCAGAAGTGTGGGCTATGTATTATCTGATCAGTCTATGGTCCCAGTAAAAGTAAAGATGCAGGAAACACAGTCTGTAAATGAGCG ACTTTTCTTTGTTCAGCTTTAGTTTTAGCAAACACCACAAATATGTTTTAAGTAACATCGCTCAAGTTTAAGTAACATCGCTCAAGTTGA TAATCTCTTGATAAGCTCTGTTGTTGACATTTTGCAGTGATACAACAGCTCCACTCATAGATTTAAACTTTTATTTTTACTTATCTTGGT CATAAGTTGGCATTCTCTCACATTCCACATGATATAGAGGGCTACGTTTTGGAATTTTCCTTTTCTTAATTGCCCAGAGTTATCAGACAG ATTATAAAAATGGCTTTTAATGGCTTAAACCATTTCTAAACCTCTATCTTAGCAGATCAATGCAGGATCTAATTCTTTTGATAAGTTCTA GCTCTAAAAGTGATAGTGGGACTGTATGTTTTCTGATACTGGTGGCTTATGTTATTAAACCTTTTTTAAAAAAGGTTCACTCTAAAAGCT GAACTACATCCTTAGTTTTCAGTCTACTTGACTCTATCAGGAGCTTTTTAAGGAAAGTAAGTATAACATGCAAAGGAAGCTTTTTTTGTA TTCATTTTGGACTCCTGTCAATAAAAATAGAAGTTTGTTGACTCGTTTTATGTTTCAATGGTGTGTGTCTTTTTACTATCAGGACATAAA TAGGGCAATCCACTTCTTTATTTTTCAACTAAAGATTGAATAGTATTGTACATTACTGCTAAAGTGACTGCTATTTCTGTATACTGTAGA AAAACCCAGGAGTGAGAGGGATTTCCCCTCATAGTACAACTGGAAGGATAGTGCTTGTAAAGAGTAGAGATGTGTACATGATGAATCATT GAGGGAGGGTGGATATTTTTATTCCTAGATATGGAGGAAACATAAGTCTGTAGTATTATAAAACTGATTGTAATAATTCTTTCCTATCAA AATCTCCATAGGTCAAAATATTGTTGGAATACTAAAATTTGCAACCTTGTTTACTTTAAAAGGTTGCCACTTTCAGTGCAGAATACTACC GGCATCTTGTTACTGCAATAGTTGGAAATAAAATGTGAAAATTAGCAAAACCATGAATGGTTTTTTTGGTTCTAAATTTAAGATGTAATA TTTCCTATAAAAGGGTGAAAGCAGTTTCTTTCTCTATAACCTCAATCACCAGTTTAGTGAGAGCCTTTCTTGGCAGGCAGGAGGCAGTGT CACTGAGGATTTTTTTCATTTACTTCATTGTACAAGTAGGAGGGTGGGTTTAATTTTCAAATCAGGTTCTGCTGTGAAGCACCAGTGTCT TGAGGCAGCTACTGATTACCTAAGTGTGGTGGCAGGGGGTAAGCCAGCTGGTGTCAAGTGAAAGGAGGGATTAGAGAAAACAGGTGTGGC ACGAAGGCAAGGAAACTGAGCAGACAAGACAGAACAATGTGTAGAATGCATATTTCCTAGTTTTCTTGAAAGATTTCAAGAAAAGTTGTT TTTTTTTTTCTAGTGGCTACTTTGCCTTAAAGAGGCTTTATAAGTTCATTCACACAGCTGGCTTCTCTGGTTTTAAGATTCTGGAGAGGA TGATAACCTAGTAACACCACAGTGCTTAAAAAAAAAAAAAAAAAAAAAACTACCATCACCAGAAAATTCCACCAGTTTGTTTTCCTTTTC TCTTTGTGTGATGTGTATGTACTTCCCAACTAAGTAAAATAAAATTTCCTCTAGTGAGTGCTTTAGGTAACCTCTTTCCATATGGCAGTA GTGAAAGAACTGAGCCTTCAGTTGATAGTTCTTCTCTCTCCAGCAAGTCGCTAAACTCCACATCCCTTCGTTTTTCCTCTGGAATGAGAA TAACAAACTATCCTAGTTTGCATTTAATCTAATGGAAACTTGAGCAAAGTTTCAATTTTCTTCCTATAAAGAAACTGACATTTTGTCAAC AATTGATGAGCCTATAGATCATACAGTGTATAGGAAGTGAAATTGAAACAGTTAAATTATGTGATATTTTTCTCTAATTGGTAAAGTACC TATTAAAATACAGCTGTTCATGAGGAGACTTACCACAATTCAAAGTGTAGCAGTTGTGTATTTTAGCATTATAATATTTGATTGAGGCCC TGAGGTGTTAATATCTCAATCTCAGAGTTAGATGTTCATGTCCTTTTTGAATTTTTTAAACATTTTTCATAATTTTTTTTTTAAGTTAGG GAGCACATTGAGTGAAGTTCTCTGTGTAGAACAATACCTTCTGCTCTGCTTCTCCCAGCTTTCACTGAGGGCTGGAAAAGGACAGGCCTG TCCAGCTGTACTGTCCCACTGTGTATGGGGAAGCTCAGGCTCTGGTGGAAGCAGGGGGCGTGGATGTCAAACAACTGATGTGGAAACAGG GAGGGAGAGATATAATGAGGCTCTCTAGGCATGTTATTTTTGACCACAAGTTTTGTTCAGTTTGCTTCAGCCAATCCAAACCATATACTA GAGTGTTCTGTAGTCACAATTCTTATTTCAAATGTAATTCAGCACCTTACATAATTTTTGAGAGGTTGTCATTCATCACATATTTACTGA GTTTCTATGTGCCAGGCTCTGTGACTGGATACTGGAGCTATCAAAATGAAAAAAATAGTGTTAAGAACTCACTCGCTGGTGTTAGAGCAG GTAGATGAGTGGCAATCCATTTAAATCCATTTGCCTTGGCTATTATTTGGAATGCCTTTTTTTTTTTTTAGTCTATCTACTGTAGGCAGA AGAATTATTTCTTTAGGGGCTAGCTGTTTATTTTGCTGGCCTTTTTTTCTCTCTTTCTCTTTTTCTTCTTAAGACGGAGTCTCGCTCTGT CCTCCAGGCTGGAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTTCTGCCTCAGCCTCCT GAGTAGCTGGGACTGCAGGTGCATGCCACCACACCCAGCTAATTTTTTAATTTTTAGTAGAGATGGGATTTTGCCACGTTGTCCAGCCTG GTCTCGAACTCCTGGCCTCAAGTGATCAGCCCTCCTCAGCCTCCCAAAGTGCTGGCATTACAGGCATGAGCCACTGCGCCCAGCCTGTTG GGTTTTTTTGGAAAAAAAACAAAAACAACAAATCATCATCCTTTCCTTTAAAATGTTTTTTTTTTTTTAAGAAACAATTTTCCCACAAAC GGTCTGATTTAACTCCATGAAATCCTCTATTTAGACTGCCTTAAAGTGAAATAACTGTTGGTGAACCATAACATTTTGCCAGCTGTGTAG TGATTAGTCCAAATATGTCTCAAGAAGTTAGCACCAAGCATTCTCATCCATTTAAACTTGATGCTAGGGCTATTTTGCAAAACTTAAAAA GATGCGATCTTGTACATATTTCTGTAACCTGAGCTGAAAACCCAAATAACAATCATTGACATACTTTAGGGCTATTGTTTCAGGTGGGGG TGTATACATCCCAGGGGCGTGGAGATGATCAATCCATTGAGGAAGTATTAAGATGATTATTTGTATTTAATCTCATCCTTTTAAATTTCT ATTTTTGTGTGTTTTATAATGTACATAATATATTGTACAATTGTACACTTCTATTATTTATAAATAAACATTTATTGGTGCATTAAGTAG AGCTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCAGACTCCTATATGGGTTTGGATCAGATTA AACCATTGAAGGAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAGCAGACATTAATATCCATGCCATATCATGTGTGTA CGCTGAAAGATACAGAGGAGGAGTGGCAAGAATTACAACAAAGCATACAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAA CACATCCTGTGTATAGCCTTTACTTTCCTGAGGAAGCTGCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAG AAGAAGAAACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAGCAAGATGAAAAACAAAACAAAG ATGATGAAGCAAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTATTACCACAGTCAAAGCAACAGAAACAAAAGCAGGCA >In-frame_ENST00000359726_ENST00000369002_TCGA-DJ-A13S-01A_APP_chr21_27252862_-_SEC63_chr6_108214782_length(amino acids)=714AA_start in transcript=200_stop in transcript=2344 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APP-SEC63 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 732_751 | 1144.3333333333333 | 771.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 732_751 | 1069.3333333333333 | 696.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 732_751 | 1013.3333333333334 | 640.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 732_751 | 1125.3333333333333 | 752.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 732_751 | 1126.0 | 753.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 732_751 | 1088.0 | 715.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000346798 | - | 18 | 18 | 695_722 | 1144.3333333333333 | 771.0 | PSEN1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000348990 | - | 16 | 16 | 695_722 | 1069.3333333333333 | 696.0 | PSEN1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000354192 | - | 15 | 15 | 695_722 | 1013.3333333333334 | 640.0 | PSEN1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000357903 | - | 17 | 17 | 695_722 | 1125.3333333333333 | 752.0 | PSEN1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000358918 | - | 17 | 17 | 695_722 | 1126.0 | 753.0 | PSEN1 |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000359726 | - | 17 | 17 | 695_722 | 1088.0 | 715.0 | PSEN1 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 732_751 | 0 | 747.0 | G(o)-alpha |
Hgene | APP | chr21:27252862 | chr6:108214782 | ENST00000440126 | - | 1 | 17 | 695_722 | 0 | 747.0 | PSEN1 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APP-SEC63 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | APP | P05067 | DB03754 | Tromethamine | Inhibitor | Small molecule | Approved |
Hgene | APP | P05067 | DB03754 | Tromethamine | Inhibitor | Small molecule | Approved |
Hgene | APP | P05067 | DB03754 | Tromethamine | Inhibitor | Small molecule | Approved |
Hgene | APP | P05067 | DB06782 | Dimercaprol | Small molecule | Approved | |
Hgene | APP | P05067 | DB06782 | Dimercaprol | Small molecule | Approved | |
Hgene | APP | P05067 | DB06782 | Dimercaprol | Small molecule | Approved | |
Hgene | APP | P05067 | DB09148 | Florbetaben (18F) | Binder | Small molecule | Approved |
Hgene | APP | P05067 | DB09148 | Florbetaben (18F) | Binder | Small molecule | Approved |
Hgene | APP | P05067 | DB09148 | Florbetaben (18F) | Binder | Small molecule | Approved |
Hgene | APP | P05067 | DB14548 | Zinc sulfate, unspecified form | Ligand | Small molecule | Approved|Experimental |
Hgene | APP | P05067 | DB14548 | Zinc sulfate, unspecified form | Ligand | Small molecule | Approved|Experimental |
Hgene | APP | P05067 | DB14548 | Zinc sulfate, unspecified form | Ligand | Small molecule | Approved|Experimental |
Hgene | APP | P05067 | DB00746 | Deferoxamine | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB00746 | Deferoxamine | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB00746 | Deferoxamine | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB01370 | Aluminium | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB01370 | Aluminium | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB01370 | Aluminium | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB01593 | Zinc | Cofactor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB01593 | Zinc | Cofactor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB01593 | Zinc | Cofactor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09130 | Copper | Aggregation inhibitor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09130 | Copper | Aggregation inhibitor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09130 | Copper | Aggregation inhibitor | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09149 | Florbetapir (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09149 | Florbetapir (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09149 | Florbetapir (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Binder | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14517 | Aluminium phosphate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14517 | Aluminium phosphate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14517 | Aluminium phosphate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14518 | Aluminum acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14518 | Aluminum acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14518 | Aluminum acetate | Small molecule | Approved|Investigational | |
Hgene | APP | P05067 | DB14533 | Zinc chloride | Ligand | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB14533 | Zinc chloride | Ligand | Small molecule | Approved|Investigational |
Hgene | APP | P05067 | DB14533 | Zinc chloride | Ligand | Small molecule | Approved|Investigational |
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Related Diseases for APP-SEC63 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APP | C0002395 | Alzheimer's Disease | 63 | CTD_human;UNIPROT |
Hgene | APP | C0011265 | Presenile dementia | 35 | CTD_human |
Hgene | APP | C0276496 | Familial Alzheimer Disease (FAD) | 35 | CTD_human |
Hgene | APP | C0494463 | Alzheimer Disease, Late Onset | 35 | CTD_human |
Hgene | APP | C0546126 | Acute Confusional Senile Dementia | 35 | CTD_human |
Hgene | APP | C0750900 | Alzheimer's Disease, Focal Onset | 35 | CTD_human |
Hgene | APP | C0750901 | Alzheimer Disease, Early Onset | 35 | CTD_human |
Hgene | APP | C0025261 | Memory Disorders | 16 | CTD_human |
Hgene | APP | C0233794 | Memory impairment | 16 | CTD_human |
Hgene | APP | C0751292 | Age-Related Memory Disorders | 16 | CTD_human |
Hgene | APP | C0751293 | Memory Disorder, Semantic | 16 | CTD_human |
Hgene | APP | C0751294 | Memory Disorder, Spatial | 16 | CTD_human |
Hgene | APP | C0751295 | Memory Loss | 16 | CTD_human |
Hgene | APP | C0027746 | Nerve Degeneration | 11 | CTD_human |
Hgene | APP | C0023186 | Learning Disorders | 8 | CTD_human |
Hgene | APP | C0751262 | Adult Learning Disorders | 8 | CTD_human |
Hgene | APP | C0751263 | Learning Disturbance | 8 | CTD_human |
Hgene | APP | C0751265 | Learning Disabilities | 8 | CTD_human |
Hgene | APP | C1330966 | Developmental Academic Disorder | 8 | CTD_human |
Hgene | APP | C2751536 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED | 7 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | APP | C0009241 | Cognition Disorders | 5 | CTD_human |
Hgene | APP | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | APP | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | APP | C0234544 | Todd Paralysis | 5 | CTD_human |
Hgene | APP | C0522224 | Paralysed | 5 | CTD_human |
Hgene | APP | C0497327 | Dementia | 3 | CTD_human;GENOMICS_ENGLAND |
Hgene | APP | C2931672 | Cerebral hemorrhage with amyloidosis, hereditary, Dutch type | 3 | CTD_human;ORPHANET |
Hgene | APP | C0270715 | Degenerative Diseases, Central Nervous System | 2 | CTD_human |
Hgene | APP | C0333463 | Senile Plaques | 2 | CTD_human |
Hgene | APP | C0524851 | Neurodegenerative Disorders | 2 | CTD_human |
Hgene | APP | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
Hgene | APP | C0751733 | Degenerative Diseases, Spinal Cord | 2 | CTD_human |
Hgene | APP | C2751494 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT | 2 | CTD_human |
Hgene | APP | C2936349 | Plaque, Amyloid | 2 | CTD_human |
Hgene | APP | C3888307 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT | 2 | CTD_human |
Hgene | APP | C3888308 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT | 2 | CTD_human |
Hgene | APP | C3888309 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT | 2 | CTD_human |
Hgene | APP | C0002622 | Amnesia | 1 | CTD_human |
Hgene | APP | C0002726 | Amyloidosis | 1 | CTD_human |
Hgene | APP | C0003469 | Anxiety Disorders | 1 | CTD_human |
Hgene | APP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | APP | C0006111 | Brain Diseases | 1 | CTD_human |
Hgene | APP | C0011573 | Endogenous depression | 1 | PSYGENET |
Hgene | APP | C0016667 | Fragile X Syndrome | 1 | CTD_human |
Hgene | APP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | APP | C0027540 | Necrosis | 1 | CTD_human |
Hgene | APP | C0033141 | Cardiomyopathies, Primary | 1 | CTD_human |
Hgene | APP | C0036529 | Myocardial Diseases, Secondary | 1 | CTD_human |
Hgene | APP | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Hgene | APP | C0037928 | Spinal Cord Diseases | 1 | CTD_human |
Hgene | APP | C0038002 | Splenomegaly | 1 | CTD_human |
Hgene | APP | C0038454 | Cerebrovascular accident | 1 | GENOMICS_ENGLAND |
Hgene | APP | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | APP | C0085220 | Cerebral Amyloid Angiopathy | 1 | CTD_human |
Hgene | APP | C0085584 | Encephalopathies | 1 | CTD_human |
Hgene | APP | C0231341 | Premature aging syndrome | 1 | CTD_human |
Hgene | APP | C0233750 | Hysterical amnesia | 1 | CTD_human |
Hgene | APP | C0233796 | Temporary Amnesia | 1 | CTD_human |
Hgene | APP | C0234985 | Mental deterioration | 1 | CTD_human |
Hgene | APP | C0236795 | Dissociative Amnesia | 1 | CTD_human |
Hgene | APP | C0262497 | Global Amnesia | 1 | CTD_human |
Hgene | APP | C0270612 | Leukoencephalopathy | 1 | GENOMICS_ENGLAND |
Hgene | APP | C0338582 | Sporadic Cerebral Amyloid Angiopathy | 1 | CTD_human |
Hgene | APP | C0338630 | Senile Paranoid Dementia | 1 | CTD_human |
Hgene | APP | C0338656 | Impaired cognition | 1 | CTD_human |
Hgene | APP | C0376280 | Anxiety States, Neurotic | 1 | CTD_human |
Hgene | APP | C0553692 | Brain hemorrhage | 1 | GENOMICS_ENGLAND |
Hgene | APP | C0750906 | Tactile Amnesia | 1 | CTD_human |
Hgene | APP | C0750907 | Amnestic State | 1 | CTD_human |
Hgene | APP | C0751071 | Familial Dementia | 1 | CTD_human |
Hgene | APP | C0751156 | FRAXA Syndrome | 1 | CTD_human |
Hgene | APP | C0751157 | FRAXE Syndrome | 1 | CTD_human |
Hgene | APP | C0878544 | Cardiomyopathies | 1 | CTD_human |
Hgene | APP | C0948008 | Ischemic stroke | 1 | GENOMICS_ENGLAND |
Hgene | APP | C1270972 | Mild cognitive disorder | 1 | CTD_human |
Hgene | APP | C1279420 | Anxiety neurosis (finding) | 1 | CTD_human |
Tgene | SEC63 | C0158683 | Polycystic liver disease | 2 | CTD_human;ORPHANET |
Tgene | SEC63 | C0022680 | Polycystic Kidney Diseases | 1 | CTD_human |
Tgene | SEC63 | C1567435 | Polycystic Kidney - body part | 1 | CTD_human |
Tgene | SEC63 | C4310769 | POLYCYSTIC LIVER DISEASE 2 WITH OR WITHOUT KIDNEY CYSTS | 1 | GENOMICS_ENGLAND |