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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APP-SYTL2 (FusionGDB2 ID:5779)

Fusion Gene Summary for APP-SYTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: APP-SYTL2
Fusion gene ID: 5779
HgeneTgene
Gene symbol

APP

SYTL2

Gene ID

351

54843

Gene nameamyloid beta precursor proteinsynaptotagmin like 2
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4CHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2A
Cytomap

21q21.3

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteisynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151
Modification date2020032920200320
UniProtAcc

P05067

.
Ensembl transtripts involved in fusion geneENST00000346798, ENST00000354192, 
ENST00000348990, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000448388, ENST00000440126, 
ENST00000439274, ENST00000474136, 
ENST00000389960, ENST00000316356, 
ENST00000528231, ENST00000527523, 
ENST00000524452, ENST00000359152, 
ENST00000354566, ENST00000525702, 
ENST00000525423, ENST00000529581, 
ENST00000389958, ENST00000533892, 
ENST00000528566, 
Fusion gene scores* DoF score31 X 25 X 12=930015 X 13 X 9=1755
# samples 3318
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1755*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APP [Title/Abstract] AND SYTL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPP(27484296)-SYTL2(85416071), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636

TgeneSYTL2

GO:0006887

exocytosis

18812475

TgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

TgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SYTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01AAPPchr21

27484296

-SYTL2chr11

85416071

-


Top

Fusion Gene ORF analysis for APP-SYTL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000346798ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000346798ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000346798ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000354192ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
intron-intronENST00000354192ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000348990ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000348990ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000357903ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000357903ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000358918ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000358918ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000359726ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000359726ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000448388ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000448388ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
In-frameENST00000440126ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5CDS-intronENST00000440126ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
intron-3CDSENST00000439274ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
intron-intronENST00000439274ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000389960APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000316356APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000528231APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000527523APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000524452APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000359152APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000354566APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000525702APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000525423APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000529581APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000389958APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-3CDSENST00000474136ENST00000533892APPchr21

27484296

-SYTL2chr11

85416071

-
5UTR-intronENST00000474136ENST00000528566APPchr21

27484296

-SYTL2chr11

85416071

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127484296-ENST00000389960SYTL2chr1185416071-193225934960308
ENST00000346798APPchr2127484296-ENST00000316356SYTL2chr1185416071-188125934960308
ENST00000346798APPchr2127484296-ENST00000528231SYTL2chr1185416071-141425934960308
ENST00000346798APPchr2127484296-ENST00000527523SYTL2chr1185416071-107025934960308
ENST00000346798APPchr2127484296-ENST00000524452SYTL2chr1185416071-96125934960309
ENST00000346798APPchr2127484296-ENST00000359152SYTL2chr1185416071-193225934960308
ENST00000346798APPchr2127484296-ENST00000354566SYTL2chr1185416071-188125934960308
ENST00000346798APPchr2127484296-ENST00000525702SYTL2chr1185416071-186825934960308
ENST00000346798APPchr2127484296-ENST00000525423SYTL2chr1185416071-186825934960308
ENST00000346798APPchr2127484296-ENST00000529581SYTL2chr1185416071-143025934960308
ENST00000346798APPchr2127484296-ENST00000389958SYTL2chr1185416071-143025934960308
ENST00000346798APPchr2127484296-ENST00000533892SYTL2chr1185416071-112125934960308
ENST00000348990APPchr2127484296-ENST00000389960SYTL2chr1185416071-20453721471073308
ENST00000348990APPchr2127484296-ENST00000316356SYTL2chr1185416071-19943721471073308
ENST00000348990APPchr2127484296-ENST00000528231SYTL2chr1185416071-15273721471073308
ENST00000348990APPchr2127484296-ENST00000527523SYTL2chr1185416071-11833721471073308
ENST00000348990APPchr2127484296-ENST00000524452SYTL2chr1185416071-10743721471073308
ENST00000348990APPchr2127484296-ENST00000359152SYTL2chr1185416071-20453721471073308
ENST00000348990APPchr2127484296-ENST00000354566SYTL2chr1185416071-19943721471073308
ENST00000348990APPchr2127484296-ENST00000525702SYTL2chr1185416071-19813721471073308
ENST00000348990APPchr2127484296-ENST00000525423SYTL2chr1185416071-19813721471073308
ENST00000348990APPchr2127484296-ENST00000529581SYTL2chr1185416071-15433721471073308
ENST00000348990APPchr2127484296-ENST00000389958SYTL2chr1185416071-15433721471073308
ENST00000348990APPchr2127484296-ENST00000533892SYTL2chr1185416071-12343721471073308
ENST00000357903APPchr2127484296-ENST00000389960SYTL2chr1185416071-20653921671093308
ENST00000357903APPchr2127484296-ENST00000316356SYTL2chr1185416071-20143921671093308
ENST00000357903APPchr2127484296-ENST00000528231SYTL2chr1185416071-15473921671093308
ENST00000357903APPchr2127484296-ENST00000527523SYTL2chr1185416071-12033921671093308
ENST00000357903APPchr2127484296-ENST00000524452SYTL2chr1185416071-10943921671093309
ENST00000357903APPchr2127484296-ENST00000359152SYTL2chr1185416071-20653921671093308
ENST00000357903APPchr2127484296-ENST00000354566SYTL2chr1185416071-20143921671093308
ENST00000357903APPchr2127484296-ENST00000525702SYTL2chr1185416071-20013921671093308
ENST00000357903APPchr2127484296-ENST00000525423SYTL2chr1185416071-20013921671093308
ENST00000357903APPchr2127484296-ENST00000529581SYTL2chr1185416071-15633921671093308
ENST00000357903APPchr2127484296-ENST00000389958SYTL2chr1185416071-15633921671093308
ENST00000357903APPchr2127484296-ENST00000533892SYTL2chr1185416071-12543921671093308
ENST00000358918APPchr2127484296-ENST00000389960SYTL2chr1185416071-20984252001126308
ENST00000358918APPchr2127484296-ENST00000316356SYTL2chr1185416071-20474252001126308
ENST00000358918APPchr2127484296-ENST00000528231SYTL2chr1185416071-15804252001126308
ENST00000358918APPchr2127484296-ENST00000527523SYTL2chr1185416071-12364252001126308
ENST00000358918APPchr2127484296-ENST00000524452SYTL2chr1185416071-11274252001126309
ENST00000358918APPchr2127484296-ENST00000359152SYTL2chr1185416071-20984252001126308
ENST00000358918APPchr2127484296-ENST00000354566SYTL2chr1185416071-20474252001126308
ENST00000358918APPchr2127484296-ENST00000525702SYTL2chr1185416071-20344252001126308
ENST00000358918APPchr2127484296-ENST00000525423SYTL2chr1185416071-20344252001126308
ENST00000358918APPchr2127484296-ENST00000529581SYTL2chr1185416071-15964252001126308
ENST00000358918APPchr2127484296-ENST00000389958SYTL2chr1185416071-15964252001126308
ENST00000358918APPchr2127484296-ENST00000533892SYTL2chr1185416071-12874252001126308
ENST00000359726APPchr2127484296-ENST00000389960SYTL2chr1185416071-20984252001126308
ENST00000359726APPchr2127484296-ENST00000316356SYTL2chr1185416071-20474252001126308
ENST00000359726APPchr2127484296-ENST00000528231SYTL2chr1185416071-15804252001126308
ENST00000359726APPchr2127484296-ENST00000527523SYTL2chr1185416071-12364252001126308
ENST00000359726APPchr2127484296-ENST00000524452SYTL2chr1185416071-11274252001126309
ENST00000359726APPchr2127484296-ENST00000359152SYTL2chr1185416071-20984252001126308
ENST00000359726APPchr2127484296-ENST00000354566SYTL2chr1185416071-20474252001126308
ENST00000359726APPchr2127484296-ENST00000525702SYTL2chr1185416071-20344252001126308
ENST00000359726APPchr2127484296-ENST00000525423SYTL2chr1185416071-20344252001126308
ENST00000359726APPchr2127484296-ENST00000529581SYTL2chr1185416071-15964252001126308
ENST00000359726APPchr2127484296-ENST00000389958SYTL2chr1185416071-15964252001126308
ENST00000359726APPchr2127484296-ENST00000533892SYTL2chr1185416071-12874252001126308
ENST00000448388APPchr2127484296-ENST00000389960SYTL2chr1185416071-19853121681013281
ENST00000448388APPchr2127484296-ENST00000316356SYTL2chr1185416071-19343121681013281
ENST00000448388APPchr2127484296-ENST00000528231SYTL2chr1185416071-14673121681013281
ENST00000448388APPchr2127484296-ENST00000527523SYTL2chr1185416071-11233121681013281
ENST00000448388APPchr2127484296-ENST00000524452SYTL2chr1185416071-10143121681013281
ENST00000448388APPchr2127484296-ENST00000359152SYTL2chr1185416071-19853121681013281
ENST00000448388APPchr2127484296-ENST00000354566SYTL2chr1185416071-19343121681013281
ENST00000448388APPchr2127484296-ENST00000525702SYTL2chr1185416071-19213121681013281
ENST00000448388APPchr2127484296-ENST00000525423SYTL2chr1185416071-19213121681013281
ENST00000448388APPchr2127484296-ENST00000529581SYTL2chr1185416071-14833121681013281
ENST00000448388APPchr2127484296-ENST00000389958SYTL2chr1185416071-14833121681013281
ENST00000448388APPchr2127484296-ENST00000533892SYTL2chr1185416071-11743121681013281
ENST00000440126APPchr2127484296-ENST00000389960SYTL2chr1185416071-21494762391177312
ENST00000440126APPchr2127484296-ENST00000316356SYTL2chr1185416071-20984762391177312
ENST00000440126APPchr2127484296-ENST00000528231SYTL2chr1185416071-16314762391177312
ENST00000440126APPchr2127484296-ENST00000527523SYTL2chr1185416071-12874762391177312
ENST00000440126APPchr2127484296-ENST00000524452SYTL2chr1185416071-11784762391177313
ENST00000440126APPchr2127484296-ENST00000359152SYTL2chr1185416071-21494762391177312
ENST00000440126APPchr2127484296-ENST00000354566SYTL2chr1185416071-20984762391177312
ENST00000440126APPchr2127484296-ENST00000525702SYTL2chr1185416071-20854762391177312
ENST00000440126APPchr2127484296-ENST00000525423SYTL2chr1185416071-20854762391177312
ENST00000440126APPchr2127484296-ENST00000529581SYTL2chr1185416071-16474762391177312
ENST00000440126APPchr2127484296-ENST00000389958SYTL2chr1185416071-16474762391177312
ENST00000440126APPchr2127484296-ENST00000533892SYTL2chr1185416071-13384762391177312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0002352740.99976474
ENST00000346798ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0002487480.99975127
ENST00000346798ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0008808490.9991191
ENST00000346798ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0024771340.9975229
ENST00000346798ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.002592280.99740773
ENST00000346798ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0002352740.99976474
ENST00000346798ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0002487480.99975127
ENST00000346798ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0002461520.9997539
ENST00000346798ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0002461520.9997539
ENST00000346798ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.0008705140.9991295
ENST00000346798ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.0008705140.9991295
ENST00000346798ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0017365070.99826354
ENST00000348990ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.000282980.99971706
ENST00000348990ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0003015180.9996985
ENST00000348990ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.001088060.998912
ENST00000348990ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0028767470.9971232
ENST00000348990ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0030824040.9969176
ENST00000348990ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.000282980.99971706
ENST00000348990ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0003015180.9996985
ENST00000348990ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0003026380.99969745
ENST00000348990ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0003026380.99969745
ENST00000348990ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.001039210.99896073
ENST00000348990ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.001039210.99896073
ENST00000348990ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.002087440.9979126
ENST00000357903ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0002986420.9997013
ENST00000357903ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0003159770.9996841
ENST00000357903ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0011661270.99883384
ENST00000357903ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0029928650.9970072
ENST00000357903ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0032930640.996707
ENST00000357903ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0002986420.9997013
ENST00000357903ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0003159770.9996841
ENST00000357903ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0003154930.9996846
ENST00000357903ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0003154930.9996846
ENST00000357903ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.0011127650.99888724
ENST00000357903ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.0011127650.99888724
ENST00000357903ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0022063420.9977937
ENST00000358918ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0003237810.9996762
ENST00000358918ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0003501260.9996499
ENST00000358918ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0014009350.9985991
ENST00000358918ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0032091280.9967908
ENST00000358918ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0035574260.9964426
ENST00000358918ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0003237810.9996762
ENST00000358918ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0003501260.9996499
ENST00000358918ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0003489890.99965096
ENST00000358918ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0003489890.99965096
ENST00000358918ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.0013378650.9986621
ENST00000358918ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.0013378650.9986621
ENST00000358918ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0025658310.9974342
ENST00000359726ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0003237810.9996762
ENST00000359726ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0003501260.9996499
ENST00000359726ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0014009350.9985991
ENST00000359726ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0032091280.9967908
ENST00000359726ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0035574260.9964426
ENST00000359726ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0003237810.9996762
ENST00000359726ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0003501260.9996499
ENST00000359726ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0003489890.99965096
ENST00000359726ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0003489890.99965096
ENST00000359726ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.0013378650.9986621
ENST00000359726ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.0013378650.9986621
ENST00000359726ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0025658310.9974342
ENST00000448388ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0023314820.99766845
ENST00000448388ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0023626270.9976374
ENST00000448388ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0082063550.9917937
ENST00000448388ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0127141350.9872859
ENST00000448388ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0145805090.98541945
ENST00000448388ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0023314820.99766845
ENST00000448388ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0023626270.9976374
ENST00000448388ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0023392410.99766076
ENST00000448388ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0023392410.99766076
ENST00000448388ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.0078911260.9921089
ENST00000448388ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.0078911260.9921089
ENST00000448388ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0105385240.9894615
ENST00000440126ENST00000389960APPchr2127484296-SYTL2chr1185416071-0.0003936240.99960643
ENST00000440126ENST00000316356APPchr2127484296-SYTL2chr1185416071-0.0004165530.9995834
ENST00000440126ENST00000528231APPchr2127484296-SYTL2chr1185416071-0.0009943520.9990056
ENST00000440126ENST00000527523APPchr2127484296-SYTL2chr1185416071-0.0021869360.997813
ENST00000440126ENST00000524452APPchr2127484296-SYTL2chr1185416071-0.0021608910.99783915
ENST00000440126ENST00000359152APPchr2127484296-SYTL2chr1185416071-0.0003936240.99960643
ENST00000440126ENST00000354566APPchr2127484296-SYTL2chr1185416071-0.0004165530.9995834
ENST00000440126ENST00000525702APPchr2127484296-SYTL2chr1185416071-0.0004170810.99958295
ENST00000440126ENST00000525423APPchr2127484296-SYTL2chr1185416071-0.0004170810.99958295
ENST00000440126ENST00000529581APPchr2127484296-SYTL2chr1185416071-0.001025280.9989747
ENST00000440126ENST00000389958APPchr2127484296-SYTL2chr1185416071-0.001025280.9989747
ENST00000440126ENST00000533892APPchr2127484296-SYTL2chr1185416071-0.0016364950.99836355

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Fusion Genomic Features for APP-SYTL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APP-SYTL2


check button Go to

FGviewer for the breakpoints of chr21:27484296-chr11:85416071

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APP

P05067

.
FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYTL2chr21:27484296chr11:85416071ENST0000038995839579_619132.0366.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052570239579_619143.0377.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST00000529581612579_619143.0377.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST00000533892511579_619103.0337.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST000003163561319768_897702.0936.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST0000038995839628_753132.0366.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST0000038995839768_897132.0366.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST000003899601319768_897677.0911.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST000005244521218768_897677.0911.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052570239628_753143.0377.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052570239768_897143.0377.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST000005275231319768_897669.0903.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST000005282311218768_897701.0935.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST00000529581612628_753143.0377.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST00000529581612768_897143.0377.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST00000533892511628_753103.0337.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST00000533892511768_897103.0337.0DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218230_26075.0771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218274_28075.0771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216230_26075.0696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216274_28075.0696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115274_2800640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217230_26075.0752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217274_28075.0752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217230_26075.0753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217274_28075.0753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217230_26075.0715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217274_28075.0715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217230_26070.0747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217274_28070.0747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-21828_18975.0771.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218374_56575.0771.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-21628_18975.0696.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216374_56575.0696.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-11528_1890640.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115374_5650640.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-21728_18975.0752.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217374_56575.0752.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-21728_18975.0753.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217374_56575.0753.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-21728_18975.0715.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217374_56575.0715.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-21728_18970.0747.0DomainE1
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217374_56570.0747.0DomainE2
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218344_36575.0771.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218724_73475.0771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216344_36575.0696.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216724_73475.0696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115344_3650640.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115724_7340640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217344_36575.0752.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217724_73475.0752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217344_36575.0753.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217724_73475.0753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217344_36575.0715.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217724_73475.0715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217344_36570.0747.0MotifOX-2
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217724_73470.0747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218131_18975.0771.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218181_18875.0771.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-21828_12375.0771.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218391_42375.0771.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218491_52275.0771.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218523_54075.0771.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-21896_11075.0771.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216131_18975.0696.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216181_18875.0696.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-21628_12375.0696.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216391_42375.0696.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216491_52275.0696.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216523_54075.0696.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-21696_11075.0696.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115131_1890640.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115181_1880640.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-11528_1230640.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115391_4230640.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115491_5220640.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115523_5400640.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-11596_1100640.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217131_18975.0752.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217181_18875.0752.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-21728_12375.0752.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217391_42375.0752.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217491_52275.0752.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217523_54075.0752.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-21796_11075.0752.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217131_18975.0753.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217181_18875.0753.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-21728_12375.0753.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217391_42375.0753.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217491_52275.0753.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217523_54075.0753.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-21796_11075.0753.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217131_18975.0715.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217181_18875.0715.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-21728_12375.0715.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217391_42375.0715.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217491_52275.0715.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217523_54075.0715.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-21796_11075.0715.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217131_18970.0747.0RegionCuBD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217181_18870.0747.0RegionNote=Zinc-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-21728_12370.0747.0RegionGFLD subdomain
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217391_42370.0747.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217491_52270.0747.0RegionNote=Heparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217523_54070.0747.0RegionCollagen-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-21796_11070.0747.0RegionHeparin-binding
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-21818_70175.0771.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218723_77075.0771.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-21618_70175.0696.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216723_77075.0696.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-11518_7010640.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115723_7700640.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-21718_70175.0752.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217723_77075.0752.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-21718_70175.0753.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217723_77075.0753.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-21718_70175.0715.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217723_77075.0715.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-21718_70170.0747.0Topological domainExtracellular
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217723_77070.0747.0Topological domainCytoplasmic
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218702_72275.0771.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216702_72275.0696.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115702_7220640.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217702_72275.0752.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217702_72275.0753.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217702_72275.0715.0TransmembraneHelical
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217702_72270.0747.0TransmembraneHelical
TgeneSYTL2chr21:27484296chr11:85416071ENST000003163561319579_619702.0936.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST00000354566713579_6191039.01273.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST000003899601319579_619677.0911.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST000005244521218579_619677.0911.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST00000525423612579_6191023.01257.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST000005275231319579_619669.0903.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST000005282311218579_619701.0935.0Compositional biasNote=Ser-rich
TgeneSYTL2chr21:27484296chr11:85416071ENST0000031635613191_57702.0936.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000003163561319628_753702.0936.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST000003545667131_571039.01273.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST00000354566713628_7531039.01273.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST00000354566713768_8971039.01273.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST00000389958391_57132.0366.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST0000038996013191_57677.0911.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000003899601319628_753677.0911.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052445212181_57677.0911.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000005244521218628_753677.0911.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST000005254236121_571023.01257.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST00000525423612628_7531023.01257.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST00000525423612768_8971023.01257.0DomainC2 2
TgeneSYTL2chr21:27484296chr11:85416071ENST00000525702391_57143.0377.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052752313191_57669.0903.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000005275231319628_753669.0903.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST0000052823112181_57701.0935.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000005282311218628_753701.0935.0DomainC2 1
TgeneSYTL2chr21:27484296chr11:85416071ENST000005295816121_57143.0377.0DomainRabBD
TgeneSYTL2chr21:27484296chr11:85416071ENST000005338925111_57103.0337.0DomainRabBD


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Fusion Gene Sequence for APP-SYTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000346798_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1932nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT
TCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGA

>In-frame_ENST00000346798_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1881nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT

>In-frame_ENST00000346798_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1414nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG

>In-frame_ENST00000346798_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1070nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA

>In-frame_ENST00000346798_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=961nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA

>In-frame_ENST00000346798_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=309AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1932nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT
TCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGA

>In-frame_ENST00000346798_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1881nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT

>In-frame_ENST00000346798_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1868nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT

>In-frame_ENST00000346798_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1868nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG
GACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAA
ATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGT
TTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATA
ACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGT

>In-frame_ENST00000346798_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1430nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG

>In-frame_ENST00000346798_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1430nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC
ACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAA
TATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGT
ATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAG

>In-frame_ENST00000346798_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000346798_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1121nt_BP=259nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGA
AAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACT
TGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGA
AGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCA
CATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGA
AGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGG
AACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAA
TACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTAC

>In-frame_ENST00000346798_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=34_stop in transcript=960
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2045nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1994nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1527nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT

>In-frame_ENST00000348990_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1183nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT

>In-frame_ENST00000348990_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1074nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG

>In-frame_ENST00000348990_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2045nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1994nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1981nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1981nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA
CATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATG
AGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAG
GTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCA
TATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAA
TGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAA

>In-frame_ENST00000348990_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1543nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA

>In-frame_ENST00000348990_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1543nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT
CTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACA
AAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTG
CCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTT
AAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGA

>In-frame_ENST00000348990_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000348990_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1234nt_BP=372nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAAT
AGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGG
AAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAG
CTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAA
TGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATG
GTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTG
GGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGG
GAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAA
ATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTAT

>In-frame_ENST00000348990_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=147_stop in transcript=1073
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2065nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2014nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1547nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG

>In-frame_ENST00000357903_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1203nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA

>In-frame_ENST00000357903_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1094nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA

>In-frame_ENST00000357903_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=309AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2065nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2014nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2001nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2001nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG
GAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGG
AATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTA
GTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTT
TATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTG
CAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAA

>In-frame_ENST00000357903_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1563nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG

>In-frame_ENST00000357903_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1563nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA
CAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCC
CAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTG
CTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACAC
CACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTG

>In-frame_ENST00000357903_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000357903_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1254nt_BP=392nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATC
GGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGA
GATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAG
AGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTC
ATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACC
CTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACA
AATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTT
CAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCA
AGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGA

>In-frame_ENST00000357903_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=167_stop in transcript=1093
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG
TAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAA

>In-frame_ENST00000358918_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2047nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000358918_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1580nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000358918_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1236nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG

>In-frame_ENST00000358918_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1127nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG

>In-frame_ENST00000358918_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=309AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG
TAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAA

>In-frame_ENST00000358918_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2047nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000358918_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2034nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000358918_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2034nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000358918_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1596nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000358918_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1596nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000358918_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000358918_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1287nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG

>In-frame_ENST00000358918_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG
TAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAA

>In-frame_ENST00000359726_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2047nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000359726_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1580nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000359726_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1236nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG

>In-frame_ENST00000359726_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1127nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG

>In-frame_ENST00000359726_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=309AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG
TAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAA

>In-frame_ENST00000359726_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2047nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000359726_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2034nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000359726_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2034nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT
GTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAA
ACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAA
CAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCT
AAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGA
AAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATG

>In-frame_ENST00000359726_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1596nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000359726_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1596nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG
TCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATA
TTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCA
AAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTT

>In-frame_ENST00000359726_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000359726_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1287nt_BP=425nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAA
AGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACAT
GGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAG
GTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGG
AATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCC
AGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAG
CCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTT
ATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAG
CAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGG
TGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAG

>In-frame_ENST00000359726_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=308AA_start in transcript=200_stop in transcript=1126
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNL
SIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPL
LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDW

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1985nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA
ACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAA

>In-frame_ENST00000448388_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1934nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA

>In-frame_ENST00000448388_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1467nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT

>In-frame_ENST00000448388_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1123nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG

>In-frame_ENST00000448388_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1014nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT

>In-frame_ENST00000448388_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1985nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA
ACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAA

>In-frame_ENST00000448388_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1934nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA

>In-frame_ENST00000448388_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1921nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA

>In-frame_ENST00000448388_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1921nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT
ACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAA
TAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAA
ATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATT
TTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAA
ACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAA

>In-frame_ENST00000448388_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1483nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT

>In-frame_ENST00000448388_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1483nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA
TTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGA
ATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATG
TGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGAT

>In-frame_ENST00000448388_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000448388_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1174nt_BP=312nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCC
ATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAAT
AAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAG
TATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTA
AGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAA
ACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGG
GACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATG
GACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTT
TTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTG
AGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGA

>In-frame_ENST00000448388_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=281AA_start in transcript=168_stop in transcript=1013
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWD
NKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTR
AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLP

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2149nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000389960_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000316356_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1631nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG

>In-frame_ENST00000440126_ENST00000528231_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1287nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA

>In-frame_ENST00000440126_ENST00000527523_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1178nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT

>In-frame_ENST00000440126_ENST00000524452_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=313AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2149nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000359152_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2098nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000354566_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2085nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000525702_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=2085nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG
GGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCC
ATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCA
CCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTT
TTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAA
AGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATT

>In-frame_ENST00000440126_ENST00000525423_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1647nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG

>In-frame_ENST00000440126_ENST00000529581_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1647nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA
TCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGG
ATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTT
CAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAAT
TCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAG

>In-frame_ENST00000440126_ENST00000389958_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------
>In-frame_ENST00000440126_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(transcript)=1338nt_BP=476nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAATATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATA
CATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGT
ACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAG
TCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAA
ATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCT
TCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAA
CCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGG
AAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTT
CCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATA

>In-frame_ENST00000440126_ENST00000533892_TCGA-D7-8574-01A_APP_chr21_27484296_-_SYTL2_chr11_85416071_length(amino acids)=312AA_start in transcript=239_stop in transcript=1177
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEYKIEKQILKTQ
KLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECL
DLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for APP-SYTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218732_75175.0771.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216732_75175.0696.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115732_7510640.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217732_75175.0752.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217732_75175.0753.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217732_75175.0715.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217732_75170.0747.0G(o)-alpha
HgeneAPPchr21:27484296chr11:85416071ENST00000346798-218695_72275.0771.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000348990-216695_72275.0696.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000354192-115695_7220640.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000357903-217695_72275.0752.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000358918-217695_72275.0753.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000359726-217695_72275.0715.0PSEN1
HgeneAPPchr21:27484296chr11:85416071ENST00000440126-217695_72270.0747.0PSEN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for APP-SYTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAPPP05067DB03754TromethamineInhibitorSmall moleculeApproved
HgeneAPPP05067DB03754TromethamineInhibitorSmall moleculeApproved
HgeneAPPP05067DB03754TromethamineInhibitorSmall moleculeApproved
HgeneAPPP05067DB06782DimercaprolSmall moleculeApproved
HgeneAPPP05067DB06782DimercaprolSmall moleculeApproved
HgeneAPPP05067DB06782DimercaprolSmall moleculeApproved
HgeneAPPP05067DB09148Florbetaben (18F)BinderSmall moleculeApproved
HgeneAPPP05067DB09148Florbetaben (18F)BinderSmall moleculeApproved
HgeneAPPP05067DB09148Florbetaben (18F)BinderSmall moleculeApproved
HgeneAPPP05067DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
HgeneAPPP05067DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
HgeneAPPP05067DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
HgeneAPPP05067DB00746DeferoxamineSmall moleculeApproved|Investigational
HgeneAPPP05067DB00746DeferoxamineSmall moleculeApproved|Investigational
HgeneAPPP05067DB00746DeferoxamineSmall moleculeApproved|Investigational
HgeneAPPP05067DB01370AluminiumSmall moleculeApproved|Investigational
HgeneAPPP05067DB01370AluminiumSmall moleculeApproved|Investigational
HgeneAPPP05067DB01370AluminiumSmall moleculeApproved|Investigational
HgeneAPPP05067DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneAPPP05067DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneAPPP05067DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneAPPP05067DB09130CopperAggregation inhibitorSmall moleculeApproved|Investigational
HgeneAPPP05067DB09130CopperAggregation inhibitorSmall moleculeApproved|Investigational
HgeneAPPP05067DB09130CopperAggregation inhibitorSmall moleculeApproved|Investigational
HgeneAPPP05067DB09149Florbetapir (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB09149Florbetapir (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB09149Florbetapir (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB09151Flutemetamol (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB09151Flutemetamol (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB09151Flutemetamol (18F)BinderSmall moleculeApproved|Investigational
HgeneAPPP05067DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14517Aluminium phosphateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14517Aluminium phosphateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14517Aluminium phosphateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14518Aluminum acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14518Aluminum acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14518Aluminum acetateSmall moleculeApproved|Investigational
HgeneAPPP05067DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational
HgeneAPPP05067DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational
HgeneAPPP05067DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational

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Related Diseases for APP-SYTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPC0002395Alzheimer's Disease63CTD_human;UNIPROT
HgeneAPPC0011265Presenile dementia35CTD_human
HgeneAPPC0276496Familial Alzheimer Disease (FAD)35CTD_human
HgeneAPPC0494463Alzheimer Disease, Late Onset35CTD_human
HgeneAPPC0546126Acute Confusional Senile Dementia35CTD_human
HgeneAPPC0750900Alzheimer's Disease, Focal Onset35CTD_human
HgeneAPPC0750901Alzheimer Disease, Early Onset35CTD_human
HgeneAPPC0025261Memory Disorders16CTD_human
HgeneAPPC0233794Memory impairment16CTD_human
HgeneAPPC0751292Age-Related Memory Disorders16CTD_human
HgeneAPPC0751293Memory Disorder, Semantic16CTD_human
HgeneAPPC0751294Memory Disorder, Spatial16CTD_human
HgeneAPPC0751295Memory Loss16CTD_human
HgeneAPPC0027746Nerve Degeneration11CTD_human
HgeneAPPC0023186Learning Disorders8CTD_human
HgeneAPPC0751262Adult Learning Disorders8CTD_human
HgeneAPPC0751263Learning Disturbance8CTD_human
HgeneAPPC0751265Learning Disabilities8CTD_human
HgeneAPPC1330966Developmental Academic Disorder8CTD_human
HgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPPC0009241Cognition Disorders5CTD_human
HgeneAPPC0011570Mental Depression5PSYGENET
HgeneAPPC0011581Depressive disorder5PSYGENET
HgeneAPPC0234544Todd Paralysis5CTD_human
HgeneAPPC0522224Paralysed5CTD_human
HgeneAPPC0497327Dementia3CTD_human;GENOMICS_ENGLAND
HgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
HgeneAPPC0270715Degenerative Diseases, Central Nervous System2CTD_human
HgeneAPPC0333463Senile Plaques2CTD_human
HgeneAPPC0524851Neurodegenerative Disorders2CTD_human
HgeneAPPC0600467Neurogenic Inflammation2CTD_human
HgeneAPPC0751733Degenerative Diseases, Spinal Cord2CTD_human
HgeneAPPC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
HgeneAPPC2936349Plaque, Amyloid2CTD_human
HgeneAPPC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
HgeneAPPC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
HgeneAPPC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
HgeneAPPC0002622Amnesia1CTD_human
HgeneAPPC0002726Amyloidosis1CTD_human
HgeneAPPC0003469Anxiety Disorders1CTD_human
HgeneAPPC0005586Bipolar Disorder1PSYGENET
HgeneAPPC0006111Brain Diseases1CTD_human
HgeneAPPC0011573Endogenous depression1PSYGENET
HgeneAPPC0016667Fragile X Syndrome1CTD_human
HgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAPPC0027540Necrosis1CTD_human
HgeneAPPC0033141Cardiomyopathies, Primary1CTD_human
HgeneAPPC0036529Myocardial Diseases, Secondary1CTD_human
HgeneAPPC0036572Seizures1GENOMICS_ENGLAND
HgeneAPPC0037928Spinal Cord Diseases1CTD_human
HgeneAPPC0038002Splenomegaly1CTD_human
HgeneAPPC0038454Cerebrovascular accident1GENOMICS_ENGLAND
HgeneAPPC0043094Weight Gain1CTD_human
HgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0085584Encephalopathies1CTD_human
HgeneAPPC0231341Premature aging syndrome1CTD_human
HgeneAPPC0233750Hysterical amnesia1CTD_human
HgeneAPPC0233796Temporary Amnesia1CTD_human
HgeneAPPC0234985Mental deterioration1CTD_human
HgeneAPPC0236795Dissociative Amnesia1CTD_human
HgeneAPPC0262497Global Amnesia1CTD_human
HgeneAPPC0270612Leukoencephalopathy1GENOMICS_ENGLAND
HgeneAPPC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0338630Senile Paranoid Dementia1CTD_human
HgeneAPPC0338656Impaired cognition1CTD_human
HgeneAPPC0376280Anxiety States, Neurotic1CTD_human
HgeneAPPC0553692Brain hemorrhage1GENOMICS_ENGLAND
HgeneAPPC0750906Tactile Amnesia1CTD_human
HgeneAPPC0750907Amnestic State1CTD_human
HgeneAPPC0751071Familial Dementia1CTD_human
HgeneAPPC0751156FRAXA Syndrome1CTD_human
HgeneAPPC0751157FRAXE Syndrome1CTD_human
HgeneAPPC0878544Cardiomyopathies1CTD_human
HgeneAPPC0948008Ischemic stroke1GENOMICS_ENGLAND
HgeneAPPC1270972Mild cognitive disorder1CTD_human
HgeneAPPC1279420Anxiety neurosis (finding)1CTD_human