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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NDUFS1-RBM39 (FusionGDB2 ID:57879)

Fusion Gene Summary for NDUFS1-RBM39

Fusion gene summary

Fusion gene information	Fusion gene name: NDUFS1-RBM39
	Fusion gene ID: 57879
		Hgene	Tgene
	Gene symbol	NDUFS1	RBM39
	Gene ID	4719	9584
	Gene name	NADH:ubiquinone oxidoreductase core subunit S1	RNA binding motif protein 39
	Synonyms	CI-75Kd\|CI-75k\|MC1DN5\|PRO1304	CAPER\|CAPERalpha\|FSAP59\|HCC1\|RNPC2
	Cytomap	2q33.3	20q11.22
	Type of gene	protein-coding	protein-coding
	Description	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)complex I 75kDa subunitcomplex I, mitochondrial respiratory chain, 75-kD subunitmitochondrial NADH-ubiquinone	RNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsepididymis secretory sperm binding proteinfunctional spliceosome-associated protein 59hepatocellular carcinoma prot
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000233190, ENST00000423725, ENST00000457011, ENST00000440274, ENST00000455934, ENST00000449699, ENST00000432169,	ENST00000253363, ENST00000361162, ENST00000528062, ENST00000407261, ENST00000397370, ENST00000463098,
Fusion gene scores	* DoF score	8 X 7 X 3=168	24 X 16 X 12=4608
	# samples	8	27
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/4608*10)=-4.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NDUFS1 [Title/Abstract] AND RBM39 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NDUFS1(207018341)-RBM39(34301018), # samples:1
Anticipated loss of major functional domain due to fusion event.	NDUFS1-RBM39 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NDUFS1-RBM39 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NDUFS1	GO:0008637	apoptotic mitochondrial changes	15186778

Fusion gene breakpoints across NDUFS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RBM39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-G4-6320	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-

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Fusion Gene ORF analysis for NDUFS1-RBM39

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000233190	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000233190	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000233190	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000233190	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000233190	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000233190	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-3CDS	ENST00000423725	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-3CDS	ENST00000423725	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-3CDS	ENST00000423725	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-3CDS	ENST00000423725	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-intron	ENST00000423725	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5UTR-intron	ENST00000423725	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-3CDS	ENST00000457011	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-3CDS	ENST00000457011	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-3CDS	ENST00000457011	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-3CDS	ENST00000457011	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-intron	ENST00000457011	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
intron-intron	ENST00000457011	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000440274	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000440274	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000440274	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000440274	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000440274	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000440274	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000455934	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000455934	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000455934	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
In-frame	ENST00000455934	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000455934	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000455934	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000449699	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000449699	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000449699	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000449699	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000449699	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000449699	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000432169	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000432169	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000432169	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
Frame-shift	ENST00000432169	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000432169	ENST00000397370	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-
5CDS-intron	ENST00000432169	ENST00000463098	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000233190	NDUFS1	chr2	207018341	-	ENST00000253363	RBM39	chr20	34301018	-	1696	328	267	824	185
ENST00000233190	NDUFS1	chr2	207018341	-	ENST00000361162	RBM39	chr20	34301018	-	1678	328	267	806	179
ENST00000233190	NDUFS1	chr2	207018341	-	ENST00000528062	RBM39	chr20	34301018	-	1408	328	267	824	185
ENST00000233190	NDUFS1	chr2	207018341	-	ENST00000407261	RBM39	chr20	34301018	-	978	328	267	824	185
ENST00000440274	NDUFS1	chr2	207018341	-	ENST00000253363	RBM39	chr20	34301018	-	1518	150	89	646	185
ENST00000440274	NDUFS1	chr2	207018341	-	ENST00000361162	RBM39	chr20	34301018	-	1500	150	89	628	179
ENST00000440274	NDUFS1	chr2	207018341	-	ENST00000528062	RBM39	chr20	34301018	-	1230	150	89	646	185
ENST00000440274	NDUFS1	chr2	207018341	-	ENST00000407261	RBM39	chr20	34301018	-	800	150	89	646	185
ENST00000455934	NDUFS1	chr2	207018341	-	ENST00000253363	RBM39	chr20	34301018	-	1532	164	61	660	199
ENST00000455934	NDUFS1	chr2	207018341	-	ENST00000361162	RBM39	chr20	34301018	-	1514	164	61	642	193
ENST00000455934	NDUFS1	chr2	207018341	-	ENST00000528062	RBM39	chr20	34301018	-	1244	164	61	660	199
ENST00000455934	NDUFS1	chr2	207018341	-	ENST00000407261	RBM39	chr20	34301018	-	814	164	61	660	199

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000233190	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.000453075	0.99954695
ENST00000233190	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.000850874	0.9991491
ENST00000233190	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.00057164	0.99942833
ENST00000233190	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.001013318	0.99898666
ENST00000440274	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.000685235	0.9993148
ENST00000440274	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.001272946	0.998727
ENST00000440274	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.000760014	0.99924004
ENST00000440274	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.001225987	0.998774
ENST00000455934	ENST00000253363	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.002009593	0.99799037
ENST00000455934	ENST00000361162	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.002835935	0.9971641
ENST00000455934	ENST00000528062	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.002168772	0.99783117
ENST00000455934	ENST00000407261	NDUFS1	chr2	207018341	-	RBM39	chr20	34301018	-	0.003489093	0.9965109

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Fusion Genomic Features for NDUFS1-RBM39

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDUFS1-RBM39

Go to
FGviewer for the breakpoints of chr2:207018341-chr20:34301018
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

409_416

365.3333333333333

531.0

Compositional bias

Note=Poly-Ala

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

409_416

365.3333333333333

525.0

Compositional bias

Note=Poly-Ala

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

409_416

343.3333333333333

509.0

Compositional bias

Note=Poly-Ala

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

445_508

365.3333333333333

531.0

Domain

RRM 3

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

445_508

365.3333333333333

525.0

Domain

RRM 3

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

445_508

343.3333333333333

509.0

Domain

RRM 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000233190

108_147

20.333333333333332

728.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000233190

245_301

20.333333333333332

728.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000233190

30_108

20.333333333333332

728.0

Domain

2Fe-2S ferredoxin-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000423725

108_147

671.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000423725

245_301

671.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000423725

30_108

671.0

Domain

2Fe-2S ferredoxin-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000432169

108_147

1.6666666666666667

617.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000432169

245_301

1.6666666666666667

617.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000432169

30_108

1.6666666666666667

617.0

Domain

2Fe-2S ferredoxin-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000440274

108_147

20.333333333333332

692.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000440274

245_301

20.333333333333332

692.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000440274

30_108

20.333333333333332

692.0

Domain

2Fe-2S ferredoxin-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000449699

108_147

20.333333333333332

728.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000449699

245_301

20.333333333333332

728.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000449699

30_108

20.333333333333332

728.0

Domain

2Fe-2S ferredoxin-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000455934

108_147

34.333333333333336

742.0

Domain

4Fe-4S His(Cys)3-ligated-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000455934

245_301

34.333333333333336

742.0

Domain

4Fe-4S Mo/W bis-MGD-type

Hgene

NDUFS1

chr2:207018341

chr20:34301018

ENST00000455934

30_108

34.333333333333336

742.0

Domain

2Fe-2S ferredoxin-type

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

41_90

365.3333333333333

531.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

41_90

365.3333333333333

525.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

41_90

343.3333333333333

509.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

153_230

365.3333333333333

531.0

Domain

RRM 1

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

250_328

365.3333333333333

531.0

Domain

RRM 2

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

153_230

365.3333333333333

525.0

Domain

RRM 1

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

250_328

365.3333333333333

525.0

Domain

RRM 2

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

153_230

343.3333333333333

509.0

Domain

RRM 1

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

250_328

343.3333333333333

509.0

Domain

RRM 2

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000253363

291_355

365.3333333333333

531.0

Region

Activating domain

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000361162

291_355

365.3333333333333

525.0

Region

Activating domain

Tgene

RBM39

chr2:207018341

chr20:34301018

ENST00000528062

291_355

343.3333333333333

509.0

Region

Activating domain

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Fusion Gene Sequence for NDUFS1-RBM39

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000233190_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1696nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA
TAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGC
TCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTA
TAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTT
ACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATA
CAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGA
TGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCC
TGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGG
TTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATAT

>In-frame_ENST00000233190_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=267_stop in transcript=824
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000233190_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1678nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTA
GCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGG
GATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGC
AATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACA
GCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGG
AAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAG
GATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGT
AAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAG
AACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTC
ACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCT
GTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAA
TGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGATGT
TTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTGCT
CTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATGAC

>In-frame_ENST00000233190_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=179AA_start in transcript=267_stop in transcript=806
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVG

--------------------------------------------------------------
>In-frame_ENST00000233190_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1408nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA
TAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGC
TCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTA
TAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTT
ACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATA
CAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGA

>In-frame_ENST00000233190_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=267_stop in transcript=824
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000233190_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=978nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA

>In-frame_ENST00000233190_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=267_stop in transcript=824
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000440274_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1518nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA
GATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGT
GCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAAC
TATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTT
TTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAA
TACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTT
GATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATC
CCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCT
GGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGAT

>In-frame_ENST00000440274_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=89_stop in transcript=646
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000440274_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1500nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTT
TAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGAT
GGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGG
GCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAA
CAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAA
GGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCA
AGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATA
GTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGG
AGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATT
TCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGG
CTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATT
AATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGAT
GTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTG
CTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATG

>In-frame_ENST00000440274_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=179AA_start in transcript=89_stop in transcript=628
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVG

--------------------------------------------------------------
>In-frame_ENST00000440274_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1230nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA
GATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGT
GCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAAC
TATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTT
TTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAA
TACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTT

>In-frame_ENST00000440274_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=89_stop in transcript=646
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000440274_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=800nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA

>In-frame_ENST00000440274_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=185AA_start in transcript=89_stop in transcript=646
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>In-frame_ENST00000455934_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1532nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA
CAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTA
GAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTC
AGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACAT
TTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCA
AAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTC
CAAACAAAATGATCCCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGA
AATAGGTTTTGTCTGGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGA
CAAGACAGCTTGATATTTCTATCAAACAAATGACTTTCATATTGCAACAATCTTTGTAAGAACCACTCAAATAAAAGTCTCTTAAAAAGG

>In-frame_ENST00000455934_ENST00000253363_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=199AA_start in transcript=61_stop in transcript=660
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------
>In-frame_ENST00000455934_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1514nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGAC
TGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGA
AGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAA
AAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGC
TGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCC
AAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATA
AAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTC
ATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATA
GGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTAC
ACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACA
AGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATG
GTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTG
CATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTT
GCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTT

>In-frame_ENST00000455934_ENST00000361162_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=193AA_start in transcript=61_stop in transcript=642
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQ
LSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPD

--------------------------------------------------------------
>In-frame_ENST00000455934_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=1244nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA
CAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTA
GAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTC
AGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACAT
TTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCA

>In-frame_ENST00000455934_ENST00000528062_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=199AA_start in transcript=61_stop in transcript=660
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------
>In-frame_ENST00000455934_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(transcript)=814nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA

>In-frame_ENST00000455934_ENST00000407261_TCGA-G4-6320_NDUFS1_chr2_207018341_-_RBM39_chr20_34301018_length(amino acids)=199AA_start in transcript=61_stop in transcript=660
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NDUFS1-RBM39

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000528062		9	16	355_406	343.3333333333333	509.0	ESR1 and ESR2
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000253363		10	17	406_530	365.3333333333333	531.0	NCOA6
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000361162		10	17	406_530	365.3333333333333	525.0	NCOA6
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000528062		9	16	406_530	343.3333333333333	509.0	NCOA6

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000253363		10	17	355_406	365.3333333333333	531.0	ESR1 and ESR2
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000361162		10	17	355_406	365.3333333333333	525.0	ESR1 and ESR2
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000253363		10	17	291_406	365.3333333333333	531.0	JUN
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000361162		10	17	291_406	365.3333333333333	525.0	JUN
Tgene	RBM39	chr2:207018341	chr20:34301018	ENST00000528062		9	16	291_406	343.3333333333333	509.0	JUN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NDUFS1-RBM39

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NDUFS1-RBM39

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NDUFS1	C0023264	Leigh Disease	12	CLINGEN;GENOMICS_ENGLAND
Hgene	NDUFS1	C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	12	CLINGEN
Hgene	NDUFS1	C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	12	CLINGEN
Hgene	NDUFS1	C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	12	CLINGEN
Hgene	NDUFS1	C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	12	CLINGEN
Hgene	NDUFS1	C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	12	CLINGEN
Hgene	NDUFS1	C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	12	CLINGEN
Hgene	NDUFS1	C1838979	MITOCHONDRIAL COMPLEX I DEFICIENCY	5	GENOMICS_ENGLAND;ORPHANET
Hgene	NDUFS1	C1656427	Early onset schizophrenia	2	PSYGENET
Hgene	NDUFS1	C0007194	Hypertrophic Cardiomyopathy	1	CTD_human
Hgene	NDUFS1	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	NDUFS1	C0036341	Schizophrenia	1	PSYGENET
Hgene	NDUFS1	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	NDUFS1	C0235874	Disease Exacerbation	1	CTD_human
Hgene	NDUFS1	C0751651	Mitochondrial Diseases	1	GENOMICS_ENGLAND
Hgene	NDUFS1	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	NDUFS1	C4551472	Hypertrophic obstructive cardiomyopathy	1	CTD_human
Hgene	NDUFS1	C4748754	MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 5	1	GENOMICS_ENGLAND;UNIPROT