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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEBL-TMEM26 (FusionGDB2 ID:58010)

Fusion Gene Summary for NEBL-TMEM26

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL-TMEM26
Fusion gene ID: 58010
HgeneTgene
Gene symbol

NEBL

TMEM26

Gene ID

10529

219623

Gene namenebulettetransmembrane protein 26
SynonymsC10orf113|LASP2|LNEBL|bA165O3.1-
Cytomap

10p12.31

10q21.2

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteintransmembrane protein 26
Modification date2020031320200313
UniProtAcc

O76041

Q5VZI3

Ensembl transtripts involved in fusion geneENST00000377122, ENST00000417816, 
ENST00000377159, ENST00000377119, 
ENST00000464278, 		ENST00000399298, 
ENST00000399293, ENST00000507507, 
Fusion gene scores* DoF score15 X 12 X 6=10802 X 3 X 2=12
# samples 162
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEBL [Title/Abstract] AND TMEM26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEBL(21309046)-TMEM26(63175881), # samples:1
NEBL(21309046)-TMEM26(63173293), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NEBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMEM26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SK-01ANEBLchr10

21309046

-TMEM26chr10

63175881

-
ChimerDB4BRCATCGA-A1-A0SK-01ANEBLchr10

21309046

-TMEM26chr10

63173293

-


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Fusion Gene ORF analysis for NEBL-TMEM26

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377122ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000377122ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000377122ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000417816ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000417816ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000417816ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000377159ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000377159ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63175881

-
5CDS-intronENST00000377159ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000377119ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000377119ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000377119ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000464278ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000464278ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-intronENST00000464278ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63175881

-
intron-3CDSENST00000377122ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-intronENST00000377122ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-5UTRENST00000377122ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63173293

-
Frame-shiftENST00000417816ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63173293

-
5CDS-intronENST00000417816ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63173293

-
5CDS-5UTRENST00000417816ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63173293

-
Frame-shiftENST00000377159ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63173293

-
5CDS-intronENST00000377159ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63173293

-
5CDS-5UTRENST00000377159ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-3CDSENST00000377119ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-intronENST00000377119ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-5UTRENST00000377119ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-3CDSENST00000464278ENST00000399298NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-intronENST00000464278ENST00000399293NEBLchr10

21309046

-TMEM26chr10

63173293

-
intron-5UTRENST00000464278ENST00000507507NEBLchr10

21309046

-TMEM26chr10

63173293

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NEBL-TMEM26


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEBL-TMEM26


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

TMEM26

Q5VZI3

FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NEBL-TMEM26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NEBL-TMEM26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEBL-TMEM26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEBL-TMEM26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEBLC0004238Atrial Fibrillation1CTD_human
HgeneNEBLC0235480Paroxysmal atrial fibrillation1CTD_human
HgeneNEBLC0340427Familial dilated cardiomyopathy1ORPHANET
HgeneNEBLC2585653Persistent atrial fibrillation1CTD_human
HgeneNEBLC3468561familial atrial fibrillation1CTD_human