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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEK10-QKI (FusionGDB2 ID:58157)

Fusion Gene Summary for NEK10-QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK10-QKI
Fusion gene ID: 58157
HgeneTgene
Gene symbol

NEK10

QKI

Gene ID

152110

9444

Gene nameNIMA related kinase 10QKI, KH domain containing RNA binding
SynonymsCILD44Hqk|QK|QK1|QK3|hqkI
Cytomap

3p24.1

6q26

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek10NIMA (never in mitosis gene a)- related kinase 10never in mitosis A-related kinase 10nimA-related protein kinase 10protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2020031320200327
UniProtAcc.

Q96PU8

Ensembl transtripts involved in fusion geneENST00000429845, ENST00000357467, 
ENST00000341435, ENST00000295720, 
ENST00000383771, ENST00000383770, 
ENST00000498182, 		ENST00000275262, 
ENST00000392127, ENST00000453779, 
ENST00000361752, ENST00000361195, 
ENST00000424802, 
Fusion gene scores* DoF score3 X 3 X 2=1823 X 23 X 9=4761
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/4761*10)=-4.14023331650551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEK10 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEK10(27258070)-QKI(163836232), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK10

GO:0006468

protein phosphorylation

20956560

HgeneNEK10

GO:0031954

positive regulation of protein autophosphorylation

20956560


check buttonFusion gene breakpoints across NEK10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across QKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAF142417NEK10chr3

27258070

-QKIchr6

163836232

+
ChiTaRS5.0N/AAF142420NEK10chr3

27258070

-QKIchr6

163836232

+
ChiTaRS5.0N/AAF142421NEK10chr3

27258070

-QKIchr6

163836232

+


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Fusion Gene ORF analysis for NEK10-QKI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000429845ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NEK10-QKI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEK10-QKI


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.QKI

Q96PU8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:23630077}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NEK10-QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NEK10-QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEK10-QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEK10-QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC0259783mixed gliomas1CTD_human
TgeneQKIC0555198Malignant Glioma1CTD_human
TgeneQKIC1269683Major Depressive Disorder1PSYGENET
TgeneQKIC2363903Angiocentric glioma1ORPHANET
TgeneQKIC3714756Intellectual Disability1GENOMICS_ENGLAND