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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEK2-METTL13 (FusionGDB2 ID:58164)

Fusion Gene Summary for NEK2-METTL13

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK2-METTL13
Fusion gene ID: 58164
HgeneTgene
Gene symbol

NEK2

METTL13

Gene ID

4751

51603

Gene nameNIMA related kinase 2eEF1A lysine and N-terminal methyltransferase
SynonymsHsPK21|NEK2A|NLK1|PPP1R111|RP675630401D24Rik|CGI-01|DFNB26|DFNB26M|DFNM1|KIAA0859|METTL13|feat
Cytomap

1q32.3

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek2NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111eEF1A lysine and N-terminal methyltransferaseantiapoptotic protein FEATdeafness (autosomal recessive, nonsyndromic) modifier 1deafness (recessive, non-syndromic) modifier 1deafness (recessive, nonsyndromic) modifier 1eEF1A-KNMTmethyltransferase like
Modification date2020031320200313
UniProtAcc

P51955

.
Ensembl transtripts involved in fusion geneENST00000366999, ENST00000540251, 
ENST00000462283, ENST00000366998, 
ENST00000458517, ENST00000362019, 
ENST00000367737, ENST00000361735, 
ENST00000466643, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: NEK2 [Title/Abstract] AND METTL13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEK2(211840447)-METTL13(171761156), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK2

GO:0006468

protein phosphorylation

21076410

HgeneNEK2

GO:0007059

chromosome segregation

14978040

HgeneNEK2

GO:0046777

protein autophosphorylation

17626005

HgeneNEK2

GO:0051299

centrosome separation

18086858


check buttonFusion gene breakpoints across NEK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across METTL13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DR-A0ZLNEK2chr1

211840447

-METTL13chr1

171761156

+


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Fusion Gene ORF analysis for NEK2-METTL13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366999ENST00000458517NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000366999ENST00000362019NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000366999ENST00000367737NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000366999ENST00000361735NEK2chr1

211840447

-METTL13chr1

171761156

+
5CDS-3UTRENST00000366999ENST00000466643NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000540251ENST00000458517NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000540251ENST00000362019NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000540251ENST00000367737NEK2chr1

211840447

-METTL13chr1

171761156

+
In-frameENST00000540251ENST00000361735NEK2chr1

211840447

-METTL13chr1

171761156

+
5CDS-3UTRENST00000540251ENST00000466643NEK2chr1

211840447

-METTL13chr1

171761156

+
5UTR-3CDSENST00000462283ENST00000458517NEK2chr1

211840447

-METTL13chr1

171761156

+
5UTR-3CDSENST00000462283ENST00000362019NEK2chr1

211840447

-METTL13chr1

171761156

+
5UTR-3CDSENST00000462283ENST00000367737NEK2chr1

211840447

-METTL13chr1

171761156

+
5UTR-3CDSENST00000462283ENST00000361735NEK2chr1

211840447

-METTL13chr1

171761156

+
5UTR-3UTRENST00000462283ENST00000466643NEK2chr1

211840447

-METTL13chr1

171761156

+
intron-3CDSENST00000366998ENST00000458517NEK2chr1

211840447

-METTL13chr1

171761156

+
intron-3CDSENST00000366998ENST00000362019NEK2chr1

211840447

-METTL13chr1

171761156

+
intron-3CDSENST00000366998ENST00000367737NEK2chr1

211840447

-METTL13chr1

171761156

+
intron-3CDSENST00000366998ENST00000361735NEK2chr1

211840447

-METTL13chr1

171761156

+
intron-3UTRENST00000366998ENST00000466643NEK2chr1

211840447

-METTL13chr1

171761156

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366999NEK2chr1211840447-ENST00000458517METTL13chr1171761156+20811250311875614
ENST00000366999NEK2chr1211840447-ENST00000362019METTL13chr1171761156+28371250311875614
ENST00000366999NEK2chr1211840447-ENST00000367737METTL13chr1171761156+28371250311875614
ENST00000366999NEK2chr1211840447-ENST00000361735METTL13chr1171761156+28371250311875614
ENST00000540251NEK2chr1211840447-ENST00000458517METTL13chr1171761156+1958112741752582
ENST00000540251NEK2chr1211840447-ENST00000362019METTL13chr1171761156+2714112741752582
ENST00000540251NEK2chr1211840447-ENST00000367737METTL13chr1171761156+2714112741752582
ENST00000540251NEK2chr1211840447-ENST00000361735METTL13chr1171761156+2714112741752582

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366999ENST00000458517NEK2chr1211840447-METTL13chr1171761156+0.0023651680.99763477
ENST00000366999ENST00000362019NEK2chr1211840447-METTL13chr1171761156+0.0010033030.9989967
ENST00000366999ENST00000367737NEK2chr1211840447-METTL13chr1171761156+0.0010033030.9989967
ENST00000366999ENST00000361735NEK2chr1211840447-METTL13chr1171761156+0.0010033030.9989967
ENST00000540251ENST00000458517NEK2chr1211840447-METTL13chr1171761156+0.0013075020.9986926
ENST00000540251ENST00000362019NEK2chr1211840447-METTL13chr1171761156+0.0005424370.99945754
ENST00000540251ENST00000367737NEK2chr1211840447-METTL13chr1171761156+0.0005424370.99945754
ENST00000540251ENST00000361735NEK2chr1211840447-METTL13chr1171761156+0.0005424370.99945754

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Fusion Genomic Features for NEK2-METTL13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NEK2chr1211840447-METTL13chr1171761156+4.86E-050.9999515
NEK2chr1211840447-METTL13chr1171761156+4.86E-050.9999515

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEK2-METTL13


check button Go to

FGviewer for the breakpoints of chr1:211840447-chr1:171761156

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK2

P51955

.
FUNCTION: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78303_362370.3333333333333446.0Coiled coilOntology_term=ECO:0000255
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-788_271370.3333333333333446.0DomainProtein kinase
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-7814_22370.3333333333333446.0Nucleotide bindingATP
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78306_334370.3333333333333446.0RegionNote=Leucine-zipper
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78333_370370.3333333333333446.0RegionNote=Required for microtubule binding and for localization to the centrosomes

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17303_3620385.0Coiled coilOntology_term=ECO:0000255
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17406_4300385.0Coiled coilOntology_term=ECO:0000255
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78406_430370.3333333333333446.0Coiled coilOntology_term=ECO:0000255
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-178_2710385.0DomainProtein kinase
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-1714_220385.0Nucleotide bindingATP
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17306_3340385.0RegionNote=Leucine-zipper
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17333_3700385.0RegionNote=Required for microtubule binding and for localization to the centrosomes


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Fusion Gene Sequence for NEK2-METTL13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366999_ENST00000458517_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2081nt_BP=1250nt
CGGGGCCCAAGGCAGGGGTGGCGGGTCAGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACT
TGGCGGCGCAACCTGCGTGAGGCAGCGCGACTCTGGCGACTGGCCGGCCATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCAT
TGGCACAGGCTCCTACGGCCGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCAT
GACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGAT
TATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGA
AAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGG
TCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAG
AATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAA
TGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACT
CGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTT
AAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGA
GAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACA
GGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAA
ACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACT
GGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAGCCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGAT
CGATCCCTCCATGTTGGAAGTGGCCACCCAGTGGTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTA
TATCGCCAGCTTGGCAGGAGGAGGAGAAGCACGGCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAAT
GAGTTGTCCGCCCCCAGCATTTGTGGAGCAATCTTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCT
TGTGTGCCGAGACTTGGGGCTAAAAGACTCAGTGCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGA
AGTGAATGAGATCCTGTTCTGTCAGCTGCACCCTGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGAC
CCTGAGGAAGCCTGGGAGGGGTTGGGATGACACGTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAG
CAGCCCTCCTGCCTAGACTGACCTTGGACTCCCAGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTT
CTTGGTTTCACACTCAGCTACATGTGACCTCCAGCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCC

>In-frame_ENST00000366999_ENST00000458517_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=614AA_start in transcript=31_stop in transcript=1875
MLGGFSIQVPGVPGPWSSALGGATCVRQRDSGDWPAMPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS
EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKP
ANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR
RIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKARE
ERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQ
WFGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDS

--------------------------------------------------------------
>In-frame_ENST00000366999_ENST00000362019_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2837nt_BP=1250nt
CGGGGCCCAAGGCAGGGGTGGCGGGTCAGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACT
TGGCGGCGCAACCTGCGTGAGGCAGCGCGACTCTGGCGACTGGCCGGCCATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCAT
TGGCACAGGCTCCTACGGCCGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCAT
GACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGAT
TATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGA
AAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGG
TCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAG
AATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAA
TGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACT
CGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTT
AAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGA
GAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACA
GGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAA
ACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACT
GGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAGCCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGAT
CGATCCCTCCATGTTGGAAGTGGCCACCCAGTGGTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTA
TATCGCCAGCTTGGCAGGAGGAGGAGAAGCACGGCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAAT
GAGTTGTCCGCCCCCAGCATTTGTGGAGCAATCTTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCT
TGTGTGCCGAGACTTGGGGCTAAAAGACTCAGTGCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGA
AGTGAATGAGATCCTGTTCTGTCAGCTGCACCCTGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGAC
CCTGAGGAAGCCTGGGAGGGGTTGGGATGACACGTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAG
CAGCCCTCCTGCCTAGACTGACCTTGGACTCCCAGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTT
CTTGGTTTCACACTCAGCTACATGTGACCTCCAGCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCC
TCTTCAGTACCACTTGGGTTGGTTTGTCTTTGCTTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCA
TGCCTTAACAAGTGTGTGCAAGCCCCTCAGAACTCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATT
CCTCTATTAGTTCTATAGGAGTGATCTCAAGTGAGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTG
AGACAGATTTGAGAGAGCATTTACTCTGTCTCCCTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACT
TCATTATTTGACAGCTTTCCTTGGTGACCCAAACCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCC
CCATGGCTTTGCATGTTAGAGACCTGGCAGACTAAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTG
CATAAAGGGTGGTGGCAGAAGTGAAAATGTTTAAGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGT
GGTTTACATGCACTGTCTCATTTAATCTGAGATAAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACAT

>In-frame_ENST00000366999_ENST00000362019_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=614AA_start in transcript=31_stop in transcript=1875
MLGGFSIQVPGVPGPWSSALGGATCVRQRDSGDWPAMPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS
EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKP
ANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR
RIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKARE
ERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQ
WFGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDS

--------------------------------------------------------------
>In-frame_ENST00000366999_ENST00000367737_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2837nt_BP=1250nt
CGGGGCCCAAGGCAGGGGTGGCGGGTCAGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACT
TGGCGGCGCAACCTGCGTGAGGCAGCGCGACTCTGGCGACTGGCCGGCCATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCAT
TGGCACAGGCTCCTACGGCCGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCAT
GACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGAT
TATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGA
AAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGG
TCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAG
AATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAA
TGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACT
CGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTT
AAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGA
GAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACA
GGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAA
ACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACT
GGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAGCCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGAT
CGATCCCTCCATGTTGGAAGTGGCCACCCAGTGGTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTA
TATCGCCAGCTTGGCAGGAGGAGGAGAAGCACGGCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAAT
GAGTTGTCCGCCCCCAGCATTTGTGGAGCAATCTTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCT
TGTGTGCCGAGACTTGGGGCTAAAAGACTCAGTGCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGA
AGTGAATGAGATCCTGTTCTGTCAGCTGCACCCTGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGAC
CCTGAGGAAGCCTGGGAGGGGTTGGGATGACACGTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAG
CAGCCCTCCTGCCTAGACTGACCTTGGACTCCCAGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTT
CTTGGTTTCACACTCAGCTACATGTGACCTCCAGCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCC
TCTTCAGTACCACTTGGGTTGGTTTGTCTTTGCTTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCA
TGCCTTAACAAGTGTGTGCAAGCCCCTCAGAACTCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATT
CCTCTATTAGTTCTATAGGAGTGATCTCAAGTGAGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTG
AGACAGATTTGAGAGAGCATTTACTCTGTCTCCCTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACT
TCATTATTTGACAGCTTTCCTTGGTGACCCAAACCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCC
CCATGGCTTTGCATGTTAGAGACCTGGCAGACTAAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTG
CATAAAGGGTGGTGGCAGAAGTGAAAATGTTTAAGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGT
GGTTTACATGCACTGTCTCATTTAATCTGAGATAAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACAT

>In-frame_ENST00000366999_ENST00000367737_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=614AA_start in transcript=31_stop in transcript=1875
MLGGFSIQVPGVPGPWSSALGGATCVRQRDSGDWPAMPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS
EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKP
ANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR
RIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKARE
ERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQ
WFGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDS

--------------------------------------------------------------
>In-frame_ENST00000366999_ENST00000361735_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2837nt_BP=1250nt
CGGGGCCCAAGGCAGGGGTGGCGGGTCAGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACT
TGGCGGCGCAACCTGCGTGAGGCAGCGCGACTCTGGCGACTGGCCGGCCATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCAT
TGGCACAGGCTCCTACGGCCGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCAT
GACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGAT
TATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGA
AAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGG
TCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAG
AATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAA
TGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACT
CGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTT
AAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGA
GAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACA
GGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAA
ACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACT
GGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAGCCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGAT
CGATCCCTCCATGTTGGAAGTGGCCACCCAGTGGTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTA
TATCGCCAGCTTGGCAGGAGGAGGAGAAGCACGGCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAAT
GAGTTGTCCGCCCCCAGCATTTGTGGAGCAATCTTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCT
TGTGTGCCGAGACTTGGGGCTAAAAGACTCAGTGCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGA
AGTGAATGAGATCCTGTTCTGTCAGCTGCACCCTGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGAC
CCTGAGGAAGCCTGGGAGGGGTTGGGATGACACGTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAG
CAGCCCTCCTGCCTAGACTGACCTTGGACTCCCAGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTT
CTTGGTTTCACACTCAGCTACATGTGACCTCCAGCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCC
TCTTCAGTACCACTTGGGTTGGTTTGTCTTTGCTTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCA
TGCCTTAACAAGTGTGTGCAAGCCCCTCAGAACTCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATT
CCTCTATTAGTTCTATAGGAGTGATCTCAAGTGAGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTG
AGACAGATTTGAGAGAGCATTTACTCTGTCTCCCTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACT
TCATTATTTGACAGCTTTCCTTGGTGACCCAAACCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCC
CCATGGCTTTGCATGTTAGAGACCTGGCAGACTAAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTG
CATAAAGGGTGGTGGCAGAAGTGAAAATGTTTAAGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGT
GGTTTACATGCACTGTCTCATTTAATCTGAGATAAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACAT

>In-frame_ENST00000366999_ENST00000361735_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=614AA_start in transcript=31_stop in transcript=1875
MLGGFSIQVPGVPGPWSSALGGATCVRQRDSGDWPAMPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS
EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKP
ANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR
RIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKARE
ERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQ
WFGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDS

--------------------------------------------------------------
>In-frame_ENST00000540251_ENST00000458517_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=1958nt_BP=1127nt
AGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACTTGGCTCCTACGGCCGCTGCCAGAAGAT
CCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGA
AGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGT
AATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCG
AGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGC
CAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAAC
ATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTT
GCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCG
AATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAAT
TCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAA
ATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGA
AAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTA
CAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACTGGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAG
CCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGATCGATCCCTCCATGTTGGAAGTGGCCACCCAGTG
GTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTATATCGCCAGCTTGGCAGGAGGAGGAGAAGCACG
GCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAATGAGTTGTCCGCCCCCAGCATTTGTGGAGCAATC
TTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCTTGTGTGCCGAGACTTGGGGCTAAAAGACTCAGT
GCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGAAGTGAATGAGATCCTGTTCTGTCAGCTGCACCC
TGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGACCCTGAGGAAGCCTGGGAGGGGTTGGGATGACAC
GTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAGCAGCCCTCCTGCCTAGACTGACCTTGGACTCCC
AGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTTCTTGGTTTCACACTCAGCTACATGTGACCTCCA

>In-frame_ENST00000540251_ENST00000458517_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=582AA_start in transcript=4_stop in transcript=1752
MLGGFSIQVPGVPGPWSSALGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVM
EYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF
VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEIL
ENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYS
LLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARP
CYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPE

--------------------------------------------------------------
>In-frame_ENST00000540251_ENST00000362019_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2714nt_BP=1127nt
AGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACTTGGCTCCTACGGCCGCTGCCAGAAGAT
CCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGA
AGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGT
AATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCG
AGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGC
CAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAAC
ATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTT
GCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCG
AATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAAT
TCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAA
ATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGA
AAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTA
CAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACTGGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAG
CCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGATCGATCCCTCCATGTTGGAAGTGGCCACCCAGTG
GTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTATATCGCCAGCTTGGCAGGAGGAGGAGAAGCACG
GCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAATGAGTTGTCCGCCCCCAGCATTTGTGGAGCAATC
TTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCTTGTGTGCCGAGACTTGGGGCTAAAAGACTCAGT
GCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGAAGTGAATGAGATCCTGTTCTGTCAGCTGCACCC
TGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGACCCTGAGGAAGCCTGGGAGGGGTTGGGATGACAC
GTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAGCAGCCCTCCTGCCTAGACTGACCTTGGACTCCC
AGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTTCTTGGTTTCACACTCAGCTACATGTGACCTCCA
GCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCCTCTTCAGTACCACTTGGGTTGGTTTGTCTTTGC
TTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCATGCCTTAACAAGTGTGTGCAAGCCCCTCAGAAC
TCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATTCCTCTATTAGTTCTATAGGAGTGATCTCAAGTG
AGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTGAGACAGATTTGAGAGAGCATTTACTCTGTCTCC
CTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACTTCATTATTTGACAGCTTTCCTTGGTGACCCAAA
CCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCCCCATGGCTTTGCATGTTAGAGACCTGGCAGACT
AAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTGCATAAAGGGTGGTGGCAGAAGTGAAAATGTTTA
AGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGTGGTTTACATGCACTGTCTCATTTAATCTGAGAT
AAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACATCAATCTTAACCATTTATTCAGAACCATTAAACC

>In-frame_ENST00000540251_ENST00000362019_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=582AA_start in transcript=4_stop in transcript=1752
MLGGFSIQVPGVPGPWSSALGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVM
EYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF
VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEIL
ENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYS
LLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARP
CYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPE

--------------------------------------------------------------
>In-frame_ENST00000540251_ENST00000367737_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2714nt_BP=1127nt
AGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACTTGGCTCCTACGGCCGCTGCCAGAAGAT
CCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGA
AGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGT
AATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCG
AGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGC
CAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAAC
ATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTT
GCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCG
AATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAAT
TCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAA
ATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGA
AAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTA
CAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACTGGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAG
CCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGATCGATCCCTCCATGTTGGAAGTGGCCACCCAGTG
GTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTATATCGCCAGCTTGGCAGGAGGAGGAGAAGCACG
GCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAATGAGTTGTCCGCCCCCAGCATTTGTGGAGCAATC
TTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCTTGTGTGCCGAGACTTGGGGCTAAAAGACTCAGT
GCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGAAGTGAATGAGATCCTGTTCTGTCAGCTGCACCC
TGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGACCCTGAGGAAGCCTGGGAGGGGTTGGGATGACAC
GTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAGCAGCCCTCCTGCCTAGACTGACCTTGGACTCCC
AGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTTCTTGGTTTCACACTCAGCTACATGTGACCTCCA
GCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCCTCTTCAGTACCACTTGGGTTGGTTTGTCTTTGC
TTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCATGCCTTAACAAGTGTGTGCAAGCCCCTCAGAAC
TCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATTCCTCTATTAGTTCTATAGGAGTGATCTCAAGTG
AGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTGAGACAGATTTGAGAGAGCATTTACTCTGTCTCC
CTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACTTCATTATTTGACAGCTTTCCTTGGTGACCCAAA
CCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCCCCATGGCTTTGCATGTTAGAGACCTGGCAGACT
AAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTGCATAAAGGGTGGTGGCAGAAGTGAAAATGTTTA
AGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGTGGTTTACATGCACTGTCTCATTTAATCTGAGAT
AAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACATCAATCTTAACCATTTATTCAGAACCATTAAACC

>In-frame_ENST00000540251_ENST00000367737_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=582AA_start in transcript=4_stop in transcript=1752
MLGGFSIQVPGVPGPWSSALGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVM
EYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF
VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEIL
ENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYS
LLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARP
CYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPE

--------------------------------------------------------------
>In-frame_ENST00000540251_ENST00000361735_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(transcript)=2714nt_BP=1127nt
AGTGCTGCTCGGGGGCTTCTCCATCCAGGTCCCTGGAGTTCCTGGTCCCTGGAGCTCCGCACTTGGCTCCTACGGCCGCTGCCAGAAGAT
CCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGA
AGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGT
AATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCG
AGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGC
CAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAAC
ATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTT
GCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCG
AATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAAT
TCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAA
ATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGA
AAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTA
CAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGATCCCACTGGCATTGTTGGTGGTAGGCCTGGGCGGGGGCAG
CCTCCCCCTCTTTGTCCACGATCATTTTCCAAAGTCCTGCATTGATGCTGTGGAGATCGATCCCTCCATGTTGGAAGTGGCCACCCAGTG
GTTTGGCTTCTCCCAGAGTGACCGAATGAAGGTCCACATTGCAGATGGCCTGGACTATATCGCCAGCTTGGCAGGAGGAGGAGAAGCACG
GCCTTGCTACGATGTCATAATGTTTGATGTTGACAGTAAGGACCCAACACTGGGAATGAGTTGTCCGCCCCCAGCATTTGTGGAGCAATC
TTTTCTACAGAAGGTTAAAAGCATCTTGACTCCTGAAGGTGTTTTTATTCTCAACCTTGTGTGCCGAGACTTGGGGCTAAAAGACTCAGT
GCTGGCTGGGCTCAAGGCAGTGTTCCCCCTCCTATATGTCCGGCGAATTGAGGGTGAAGTGAATGAGATCCTGTTCTGTCAGCTGCACCC
TGAGCAAAAACTTGCCACACCAGAGCTCCTAGAAACAGCCCAGGCTTTGGAGCGGACCCTGAGGAAGCCTGGGAGGGGTTGGGATGACAC
GTATGTCTTGTCAGATATGCTCAAGACGGTGAAAATTGTGTGACTGCTTAGGCCAAGCAGCCCTCCTGCCTAGACTGACCTTGGACTCCC
AGCCTGCCAGAGAATGAAGAAATACAACGCACAGTACTTTTGAAGCTTCGTATTTTTCTTGGTTTCACACTCAGCTACATGTGACCTCCA
GCTTGGTGAGGTTGCCTGAAGATTAGGGAAAATAAAAATGTCCTTCCCATCTTGTCCTCTTCAGTACCACTTGGGTTGGTTTGTCTTTGC
TTCCTACACCACGTCCTTGAGTGGAGTTCCCTGCTGAAGCCCCTAGCACACACTGCATGCCTTAACAAGTGTGTGCAAGCCCCTCAGAAC
TCAAGACATCCAAATTTTATTGCGTCTCTACTTATACTGGTTTGCTTTTGATTTATTCCTCTATTAGTTCTATAGGAGTGATCTCAAGTG
AGATAGCAGAGCAAGATGCCAAAAGACCATAAATAGAGTAAGGTTTCTATAGATGTGAGACAGATTTGAGAGAGCATTTACTCTGTCTCC
CTGTGGATGAAACTGCTGCTGAAATGGTTCCAATTTTTAGGAATCTGCTTACCCACTTCATTATTTGACAGCTTTCCTTGGTGACCCAAA
CCTTGTAGCCTAAGCCATTTGTCTTTTTCTCAGTGGAGGGAGTGTATGGACCTGGCCCCATGGCTTTGCATGTTAGAGACCTGGCAGACT
AAAGTCTCTAGTGTTTGTTTGCTCACATTTGCTGAGTGACAGCTATGTGCCAGACTGCATAAAGGGTGGTGGCAGAAGTGAAAATGTTTA
AGAATGACCAAAAACATTAGTAATGAAAGTTAATGTGTTCCAGGCATTCTTCTAAGTGGTTTACATGCACTGTCTCATTTAATCTGAGAT
AAAGGATACTTAAGCCCAAACTATATCTAAACCCAAATCTCACTTGGCTGGAAACATCAATCTTAACCATTTATTCAGAACCATTAAACC

>In-frame_ENST00000540251_ENST00000361735_TCGA-DR-A0ZL_NEK2_chr1_211840447_-_METTL13_chr1_171761156_length(amino acids)=582AA_start in transcript=4_stop in transcript=1752
MLGGFSIQVPGVPGPWSSALGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVM
EYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF
VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEIL
ENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYS
LLKERKFLSLASNPEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARP
CYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NEK2-METTL13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17301_4450385.0CEP85
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78301_445370.3333333333333446.0CEP85
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17264_4450385.0PCNT
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78264_445370.3333333333333446.0PCNT
HgeneNEK2chr1:211840447chr1:171761156ENST00000366998-17403_4390385.0SAV1 and STK3/MST2
HgeneNEK2chr1:211840447chr1:171761156ENST00000366999-78403_439370.3333333333333446.0SAV1 and STK3/MST2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEK2-METTL13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for NEK2-METTL13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEK2C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNEK2C0027626Neoplasm Invasiveness1CTD_human
HgeneNEK2C0035334Retinitis Pigmentosa1ORPHANET
HgeneNEK2C2239176Liver carcinoma1CTD_human