FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NEMF-SOS2 (FusionGDB2 ID:58253)

Fusion Gene Summary for NEMF-SOS2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEMF-SOS2
Fusion gene ID: 58253
HgeneTgene
Gene symbol

NEMF

SOS2

Gene ID

9147

6655

Gene namenuclear export mediator factorSOS Ras/Rho guanine nucleotide exchange factor 2
SynonymsNY-CO-1|SDCCAG1NS9|SOS-2
Cytomap

14q21.3

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear export mediator factor NEMFantigen NY-CO-1serologically defined colon cancer antigen 1son of sevenless homolog 2guanine nucleotide releasing factor
Modification date2020031320200327
UniProtAcc

O60524

.
Ensembl transtripts involved in fusion geneENST00000298310, ENST00000382135, 
ENST00000545773, ENST00000556925, 
ENST00000546046, ENST00000556672, 
ENST00000216373, ENST00000543680, 
ENST00000555794, 
Fusion gene scores* DoF score19 X 28 X 8=425613 X 13 X 9=1521
# samples 2617
** MAII scorelog2(26/4256*10)=-4.03291462247274
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1521*10)=-3.16141350158679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEMF [Title/Abstract] AND SOS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEMF(50300141)-SOS2(50587102), # samples:3
NEMF(50280706)-SOS2(50612314), # samples:3
SOS2(50697915)-NEMF(50262662), # samples:2
Anticipated loss of major functional domain due to fusion event.NEMF-SOS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NEMF-SOS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SOS2-NEMF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SOS2-NEMF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NEMF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SOS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A27B-01ANEMFchr14

50300141

-SOS2chr14

50587102

-
ChimerDB4ESCATCGA-L5-A43I-01ANEMFchr14

50280706

-SOS2chr14

50612314

-
ChimerDB4LUADTCGA-MP-A4TI-01ANEMFchr14

50281472

-SOS2chr14

50587102

-
ChimerDB4BRCATCGA-C8-A27B-01ANEMFchr14

50300141

-SOS2chr14

50587102

-
ChimerDB4ESCATCGA-L5-A43INEMFchr14

50280706

-SOS2chr14

50612314

-
ChimerDB4BRCATCGA-C8-A27B-01ANEMFchr14

50300141

-SOS2chr14

50587102

-
ChimerDB4ESCATCGA-L5-A43I-01ANEMFchr14

50280706

-SOS2chr14

50612314

-
ChimerDB4LUADTCGA-MP-A4TI-01ANEMFchr14

50280706

-SOS2chr14

50587102

-
ChiTaRS5.0N/AAW581999NEMFchr14

50292260

+SOS2chr14

50685048

+


Top

Fusion Gene ORF analysis for NEMF-SOS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000298310ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000298310ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
5CDS-intronENST00000298310ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-intronENST00000382135ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000545773ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000545773ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
5CDS-intronENST00000545773ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000556925ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000556925ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-intronENST00000556925ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000546046ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000546046ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
5CDS-intronENST00000546046ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000216373NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000543680NEMFchr14

50300141

-SOS2chr14

50587102

-
intron-intronENST00000556672ENST00000555794NEMFchr14

50300141

-SOS2chr14

50587102

-
Frame-shiftENST00000298310ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
Frame-shiftENST00000298310ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
5CDS-intronENST00000298310ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000382135ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000382135ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-intronENST00000382135ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
Frame-shiftENST00000545773ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
Frame-shiftENST00000545773ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
5CDS-intronENST00000545773ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
5UTR-3CDSENST00000556925ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
5UTR-3CDSENST00000556925ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
5UTR-intronENST00000556925ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000546046ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000546046ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-intronENST00000546046ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000556672ENST00000216373NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-3CDSENST00000556672ENST00000543680NEMFchr14

50280706

-SOS2chr14

50612314

-
intron-intronENST00000556672ENST00000555794NEMFchr14

50280706

-SOS2chr14

50612314

-
In-frameENST00000298310ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000298310ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
5CDS-intronENST00000298310ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-intronENST00000382135ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000545773ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000545773ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
5CDS-intronENST00000545773ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
5UTR-3CDSENST00000556925ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
5UTR-3CDSENST00000556925ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
5UTR-intronENST00000556925ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000546046ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000546046ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
5CDS-intronENST00000546046ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000216373NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000543680NEMFchr14

50281472

-SOS2chr14

50587102

-
intron-intronENST00000556672ENST00000555794NEMFchr14

50281472

-SOS2chr14

50587102

-
In-frameENST00000298310ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
In-frameENST00000298310ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
5CDS-intronENST00000298310ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000382135ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-intronENST00000382135ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
In-frameENST00000545773ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
In-frameENST00000545773ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
5CDS-intronENST00000545773ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
5UTR-3CDSENST00000556925ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
5UTR-3CDSENST00000556925ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
5UTR-intronENST00000556925ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000546046ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000546046ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-intronENST00000546046ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000216373NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-3CDSENST00000556672ENST00000543680NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-intronENST00000556672ENST00000555794NEMFchr14

50280706

-SOS2chr14

50587102

-
intron-intronENST00000298310ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000298310ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000298310ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000382135ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000382135ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000382135ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000545773ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000545773ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000545773ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556925ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556925ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556925ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000546046ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000546046ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000546046ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556672ENST00000216373NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556672ENST00000543680NEMFchr14

50292260

+SOS2chr14

50685048

+
intron-intronENST00000556672ENST00000555794NEMFchr14

50292260

+SOS2chr14

50685048

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298310NEMFchr1450281472-ENST00000216373SOS2chr1450587102-396621314502750766
ENST00000298310NEMFchr1450281472-ENST00000543680SOS2chr1450587102-278521314502750766
ENST00000545773NEMFchr1450281472-ENST00000216373SOS2chr1450587102-34581623682242724
ENST00000545773NEMFchr1450281472-ENST00000543680SOS2chr1450587102-22771623682242724
ENST00000546046NEMFchr1450281472-ENST00000216373SOS2chr1450587102-35431708272327766
ENST00000546046NEMFchr1450281472-ENST00000543680SOS2chr1450587102-23621708272327766
ENST00000298310NEMFchr1450280706-ENST00000216373SOS2chr1450587102-402921944502813787
ENST00000298310NEMFchr1450280706-ENST00000543680SOS2chr1450587102-284821944502813787
ENST00000545773NEMFchr1450280706-ENST00000216373SOS2chr1450587102-35211686682305745
ENST00000545773NEMFchr1450280706-ENST00000543680SOS2chr1450587102-23401686682305745

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298310ENST00000216373NEMFchr1450281472-SOS2chr1450587102-0.000361110.9996389
ENST00000298310ENST00000543680NEMFchr1450281472-SOS2chr1450587102-0.0011874280.99881256
ENST00000545773ENST00000216373NEMFchr1450281472-SOS2chr1450587102-0.0002567780.99974316
ENST00000545773ENST00000543680NEMFchr1450281472-SOS2chr1450587102-0.0010756720.9989243
ENST00000546046ENST00000216373NEMFchr1450281472-SOS2chr1450587102-0.0003509630.99964905
ENST00000546046ENST00000543680NEMFchr1450281472-SOS2chr1450587102-0.0012477010.99875224
ENST00000298310ENST00000216373NEMFchr1450280706-SOS2chr1450587102-0.0003576170.9996424
ENST00000298310ENST00000543680NEMFchr1450280706-SOS2chr1450587102-0.0011359240.99886405
ENST00000545773ENST00000216373NEMFchr1450280706-SOS2chr1450587102-0.000282430.99971753
ENST00000545773ENST00000543680NEMFchr1450280706-SOS2chr1450587102-0.001126890.99887305

Top

Fusion Genomic Features for NEMF-SOS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NEMF-SOS2


check button Go to

FGviewer for the breakpoints of chr14:50281472-chr14:50587102

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEMF

O60524

.
FUNCTION: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEMFchr14:50280706chr14:50587102ENST00000298310-1833296_359581.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000298310-1833483_514581.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000545773-1732296_359539.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000545773-1732483_514539.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000298310-1733296_359560.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000298310-1733483_514560.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000545773-1632296_359518.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000545773-1632483_514518.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000546046-1732296_359560.33333333333341056.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000546046-1732483_514560.33333333333341056.0Coiled coilOntology_term=ECO:0000255
TgeneSOS2chr14:50280706chr14:50587102ENST0000021637320231180_11831126.33333333333331333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr14:50280706chr14:50587102ENST0000021637320231203_12081126.33333333333331333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr14:50281472chr14:50587102ENST0000021637320231180_11831126.33333333333331333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr14:50281472chr14:50587102ENST0000021637320231203_12081126.33333333333331333.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEMFchr14:50280706chr14:50587102ENST00000298310-1833869_894581.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000382135-19296_3590.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000382135-19483_5140.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000382135-19869_8940.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000545773-1732869_894539.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000546046-132296_35901056.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000546046-132483_51401056.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50280706chr14:50587102ENST00000546046-132869_89401056.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000298310-1733869_894560.33333333333341077.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000382135-19296_3590.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000382135-19483_5140.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000382135-19869_8940.0277.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000545773-1632869_894518.33333333333341035.0Coiled coilOntology_term=ECO:0000255
HgeneNEMFchr14:50281472chr14:50587102ENST00000546046-1732869_894560.33333333333341056.0Coiled coilOntology_term=ECO:0000255
TgeneSOS2chr14:50280706chr14:50587102ENST000002163732023755_7581126.33333333333331333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr14:50281472chr14:50587102ENST000002163732023755_7581126.33333333333331333.0Compositional biasNote=Poly-Pro
TgeneSOS2chr14:50280706chr14:50587102ENST000002163732023198_3881126.33333333333331333.0DomainDH
TgeneSOS2chr14:50280706chr14:50587102ENST000002163732023442_5461126.33333333333331333.0DomainPH
TgeneSOS2chr14:50280706chr14:50587102ENST000002163732023595_7391126.33333333333331333.0DomainN-terminal Ras-GEF
TgeneSOS2chr14:50280706chr14:50587102ENST000002163732023778_10171126.33333333333331333.0DomainRas-GEF
TgeneSOS2chr14:50281472chr14:50587102ENST000002163732023198_3881126.33333333333331333.0DomainDH
TgeneSOS2chr14:50281472chr14:50587102ENST000002163732023442_5461126.33333333333331333.0DomainPH
TgeneSOS2chr14:50281472chr14:50587102ENST000002163732023595_7391126.33333333333331333.0DomainN-terminal Ras-GEF
TgeneSOS2chr14:50281472chr14:50587102ENST000002163732023778_10171126.33333333333331333.0DomainRas-GEF


Top

Fusion Gene Sequence for NEMF-SOS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000298310_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=3966nt_BP=2131nt
ATTTCAAAATCTTATGTCAAAGTAAGCGCGCAGAAAGGGGTCCTTGCTCTTCTACACTGAGCCCTACGGCCCCCCTGTGGGGAAATACTC
CTGATAATCATCTCGAAAATTGTTTCGACCAGCAGGGGTCACTATGAAGGCTGACTTGAGCCCAAGACACAATGGGGCACGGTAACCAGA
CTGGTCCGTAAGGGTTCCAGGAAGGAATGCAGTTTCAAGAGAACAGTTTGAATCTTTATTCGAATTTGAATTTTGGTACAATGAAGAGAG
TCAGCTGCAACTTGACAATCGAAATCTTCAGAAAAGCGACACAAATACGTTCGCCTCGAGGAATATTGGGTCTTCTGCGCGGCCGTAGAG
CTCCGCCAAGTGCGCCTGCGCGGAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCC
ATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTAT
GATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACA
ACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACATTTGAAGAGTCGGAGATTAGTCAGTGCA
AAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCATTTAATCATTGAGCTCTATGATAGGGGG
AACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAGGCAGATGATGTTAAATTTGCTGTTCGT
GAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACTGAAATAGTAGCCAGCGCACCTAAGGGT
GAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGTCTTTTAGAAAATGGATTCTCGGGTAAT
GTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAAGCAGAAGACTATATGAAAACAACATCC
AACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGATAAACCAGTTGAAGACATACTGACGTAT
GAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCATTTGACAAGGCGGTGGATGAATTTTAT
TCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAGAAATTAGATAATGTTCGAAAGGATCAC
GAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATAGAAATGAACCTACAAATAGTTGACAGA
GCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATTGTGAAAGAAGCCCAGGCTCAAGGAGAC
CCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGAAATCCATACTTGTTATCAGAGGAGGAA
GATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAAAAGAAAAAACAAAAGAATAAACAGCTG
CAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCCAATGCCAAAAAGTATTATGATCACAAG
AGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCAGAAAAGAAAACAAAGCAAACATTAAAA
GAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTGTGGTTCATTAGCTCAGAGAACTATCTA
ATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGAGTCTTTCTTTAGTTCATGTGGTAGTTTA
CATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATG
AAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTT
GATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACAC
TTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCA
AATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCAT
CCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCAC
CCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTT
GTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAA
ATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCT
CAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAA
AGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATG
GTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTT
CTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTG
TAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCC
TTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTT
TATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCAT
AAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAAT
TTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAA
GCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGC
CACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAACAAGATTAATAAATCACCCCAGTCTTAATTTT

>In-frame_ENST00000298310_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=766AA_start in transcript=450_stop in transcript=2750
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAF
DGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAH

--------------------------------------------------------------
>In-frame_ENST00000298310_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=2785nt_BP=2131nt
ATTTCAAAATCTTATGTCAAAGTAAGCGCGCAGAAAGGGGTCCTTGCTCTTCTACACTGAGCCCTACGGCCCCCCTGTGGGGAAATACTC
CTGATAATCATCTCGAAAATTGTTTCGACCAGCAGGGGTCACTATGAAGGCTGACTTGAGCCCAAGACACAATGGGGCACGGTAACCAGA
CTGGTCCGTAAGGGTTCCAGGAAGGAATGCAGTTTCAAGAGAACAGTTTGAATCTTTATTCGAATTTGAATTTTGGTACAATGAAGAGAG
TCAGCTGCAACTTGACAATCGAAATCTTCAGAAAAGCGACACAAATACGTTCGCCTCGAGGAATATTGGGTCTTCTGCGCGGCCGTAGAG
CTCCGCCAAGTGCGCCTGCGCGGAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCC
ATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTAT
GATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACA
ACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACATTTGAAGAGTCGGAGATTAGTCAGTGCA
AAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCATTTAATCATTGAGCTCTATGATAGGGGG
AACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAGGCAGATGATGTTAAATTTGCTGTTCGT
GAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACTGAAATAGTAGCCAGCGCACCTAAGGGT
GAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGTCTTTTAGAAAATGGATTCTCGGGTAAT
GTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAAGCAGAAGACTATATGAAAACAACATCC
AACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGATAAACCAGTTGAAGACATACTGACGTAT
GAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCATTTGACAAGGCGGTGGATGAATTTTAT
TCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAGAAATTAGATAATGTTCGAAAGGATCAC
GAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATAGAAATGAACCTACAAATAGTTGACAGA
GCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATTGTGAAAGAAGCCCAGGCTCAAGGAGAC
CCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGAAATCCATACTTGTTATCAGAGGAGGAA
GATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAAAAGAAAAAACAAAAGAATAAACAGCTG
CAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCCAATGCCAAAAAGTATTATGATCACAAG
AGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCAGAAAAGAAAACAAAGCAAACATTAAAA
GAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTGTGGTTCATTAGCTCAGAGAACTATCTA
ATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGAGTCTTTCTTTAGTTCATGTGGTAGTTTA
CATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATG
AAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTT
GATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACAC
TTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCA
AATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCAT
CCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCAC

>In-frame_ENST00000298310_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=766AA_start in transcript=450_stop in transcript=2750
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAF
DGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAH

--------------------------------------------------------------
>In-frame_ENST00000545773_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=3458nt_BP=1623nt
GAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCA
TTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACC
TTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGA
ATATGATGCCGTCTAGTTTTGCCATGAAGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTG
ATGAGGCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGT
TGACTGAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAAC
ACTGTCTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGC
AGAAAGCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAG
CAGATAAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTG
AATCATTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCAT
TGAAGAAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGC
TCATAGAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGT
TAATTGTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGC
TAAGAAATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAG
GAAAAAAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCAT
ATGCCAATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGT
CAGCAGAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAAT
TTCTGTGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACAC
CAGAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTG
ATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAA
AACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCC
CTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATT
CAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATG
TGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGC
CACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGC
CATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACA
AATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAG
GTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAA
ATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCA
GTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTAC
ATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATG
AAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGG
GAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAA
CAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGC
CTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTA
ACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTT
TATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGT
GCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAA

>In-frame_ENST00000545773_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=724AA_start in transcript=68_stop in transcript=2242
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKGNIVLTDYEYVIL
NILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDI
EKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKA
LQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQ
TNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVE
AAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPP
LPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPP
LGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENA

--------------------------------------------------------------
>In-frame_ENST00000545773_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=2277nt_BP=1623nt
GAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCA
TTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACC
TTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGA
ATATGATGCCGTCTAGTTTTGCCATGAAGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTG
ATGAGGCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGT
TGACTGAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAAC
ACTGTCTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGC
AGAAAGCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAG
CAGATAAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTG
AATCATTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCAT
TGAAGAAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGC
TCATAGAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGT
TAATTGTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGC
TAAGAAATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAG
GAAAAAAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCAT
ATGCCAATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGT
CAGCAGAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAAT
TTCTGTGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACAC
CAGAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTG
ATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAA
AACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCC
CTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATT
CAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATG
TGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGC
CACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGC

>In-frame_ENST00000545773_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=724AA_start in transcript=68_stop in transcript=2242
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKGNIVLTDYEYVIL
NILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDI
EKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKA
LQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQ
TNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVE
AAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPP
LPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPP
LGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENA

--------------------------------------------------------------
>In-frame_ENST00000546046_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=3543nt_BP=1708nt
TTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTG
CTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTA
CTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACAT
TTGAAGAGTCGGAGATTAGTCAGTGCAAAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCAT
TTAATCATTGAGCTCTATGATAGGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAG
GCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACT
GAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGT
CTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAA
GCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGAT
AAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCA
TTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAG
AAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATA
GAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATT
GTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGA
AATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAA
AAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCC
AATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCA
GAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTG
TGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGAG
TCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCAT
GATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCC
AGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCA
CCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGAC
TGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTC
AGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCA
AAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATAT
GTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAA
TGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGAT
CAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATG
GTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAA
TTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTA
GGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAG
TAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAA
AGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTT
AATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATA
ATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTT
CTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTA
AACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGT
AGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAACAAGA

>In-frame_ENST00000546046_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=766AA_start in transcript=27_stop in transcript=2327
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAF
DGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAH

--------------------------------------------------------------
>In-frame_ENST00000546046_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(transcript)=2362nt_BP=1708nt
TTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTG
CTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTA
CTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACAT
TTGAAGAGTCGGAGATTAGTCAGTGCAAAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCAT
TTAATCATTGAGCTCTATGATAGGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAG
GCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACT
GAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGT
CTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAA
GCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGAT
AAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCA
TTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAG
AAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATA
GAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATT
GTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGA
AATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAA
AAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCC
AATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCA
GAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTG
TGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGAG
TCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCAT
GATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCC
AGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCA
CCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGAC
TGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTC
AGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCA
AAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATAT

>In-frame_ENST00000546046_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50281472_-_SOS2_chr14_50587102_length(amino acids)=766AA_start in transcript=27_stop in transcript=2327
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAF
DGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAH

--------------------------------------------------------------
>In-frame_ENST00000298310_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(transcript)=4029nt_BP=2194nt
ATTTCAAAATCTTATGTCAAAGTAAGCGCGCAGAAAGGGGTCCTTGCTCTTCTACACTGAGCCCTACGGCCCCCCTGTGGGGAAATACTC
CTGATAATCATCTCGAAAATTGTTTCGACCAGCAGGGGTCACTATGAAGGCTGACTTGAGCCCAAGACACAATGGGGCACGGTAACCAGA
CTGGTCCGTAAGGGTTCCAGGAAGGAATGCAGTTTCAAGAGAACAGTTTGAATCTTTATTCGAATTTGAATTTTGGTACAATGAAGAGAG
TCAGCTGCAACTTGACAATCGAAATCTTCAGAAAAGCGACACAAATACGTTCGCCTCGAGGAATATTGGGTCTTCTGCGCGGCCGTAGAG
CTCCGCCAAGTGCGCCTGCGCGGAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCC
ATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTAT
GATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACA
ACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACATTTGAAGAGTCGGAGATTAGTCAGTGCA
AAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCATTTAATCATTGAGCTCTATGATAGGGGG
AACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAGGCAGATGATGTTAAATTTGCTGTTCGT
GAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACTGAAATAGTAGCCAGCGCACCTAAGGGT
GAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGTCTTTTAGAAAATGGATTCTCGGGTAAT
GTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAAGCAGAAGACTATATGAAAACAACATCC
AACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGATAAACCAGTTGAAGACATACTGACGTAT
GAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCATTTGACAAGGCGGTGGATGAATTTTAT
TCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAGAAATTAGATAATGTTCGAAAGGATCAC
GAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATAGAAATGAACCTACAAATAGTTGACAGA
GCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATTGTGAAAGAAGCCCAGGCTCAAGGAGAC
CCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGAAATCCATACTTGTTATCAGAGGAGGAA
GATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAAAAGAAAAAACAAAAGAATAAACAGCTG
CAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCCAATGCCAAAAAGTATTATGATCACAAG
AGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCAGAAAAGAAAACAAAGCAAACATTAAAA
GAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTGTGGTTCATTAGCTCAGAGAACTATCTA
ATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGGAGACATTTATGTACATGCTGATCTTCAT
GGAGCTACTAGCTGTGTAATTAAGAATCCAACAGAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATT
CCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATT
CCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCG
CCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAG
CCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACA
CCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGG
CAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTA
GAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAA
AAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAA
AAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAG
AATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTC
AAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGA
CCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAA
ATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGT
AAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTT
TAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTA
ATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAG
GAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGG
TAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTC
GTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGC

>In-frame_ENST00000298310_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(amino acids)=787AA_start in transcript=450_stop in transcript=2813
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAI
PPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPST

--------------------------------------------------------------
>In-frame_ENST00000298310_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(transcript)=2848nt_BP=2194nt
ATTTCAAAATCTTATGTCAAAGTAAGCGCGCAGAAAGGGGTCCTTGCTCTTCTACACTGAGCCCTACGGCCCCCCTGTGGGGAAATACTC
CTGATAATCATCTCGAAAATTGTTTCGACCAGCAGGGGTCACTATGAAGGCTGACTTGAGCCCAAGACACAATGGGGCACGGTAACCAGA
CTGGTCCGTAAGGGTTCCAGGAAGGAATGCAGTTTCAAGAGAACAGTTTGAATCTTTATTCGAATTTGAATTTTGGTACAATGAAGAGAG
TCAGCTGCAACTTGACAATCGAAATCTTCAGAAAAGCGACACAAATACGTTCGCCTCGAGGAATATTGGGTCTTCTGCGCGGCCGTAGAG
CTCCGCCAAGTGCGCCTGCGCGGAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCC
ATGAAGAGCCGCTTTAGCACCATTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTAT
GATGTGGATAATAAGACATACCTTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACA
ACAGAATTTGAGTGGCCTAAGAATATGATGCCGTCTAGTTTTGCCATGAAGTGCCGAAAACATTTGAAGAGTCGGAGATTAGTCAGTGCA
AAACAGCTTGGTGTGGATAGAATTGTAGATTTTCAATTTGGAAGTGATGAAGCTGCTTACCATTTAATCATTGAGCTCTATGATAGGGGG
AACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTGATGAGGCAGATGATGTTAAATTTGCTGTTCGT
GAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGTTGACTGAAATAGTAGCCAGCGCACCTAAGGGT
GAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAACACTGTCTTTTAGAAAATGGATTCTCGGGTAAT
GTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGCAGAAAGCAGAAGACTATATGAAAACAACATCC
AACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAGCAGATAAACCAGTTGAAGACATACTGACGTAT
GAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTGAATCATTTGACAAGGCGGTGGATGAATTTTAT
TCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCATTGAAGAAATTAGATAATGTTCGAAAGGATCAC
GAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGCTCATAGAAATGAACCTACAAATAGTTGACAGA
GCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGTTAATTGTGAAAGAAGCCCAGGCTCAAGGAGAC
CCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGCTAAGAAATCCATACTTGTTATCAGAGGAGGAA
GATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAGGAAAAAAGAAAAAACAAAAGAATAAACAGCTG
CAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCATATGCCAATGCCAAAAAGTATTATGATCACAAG
AGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGTCAGCAGAAAAGAAAACAAAGCAAACATTAAAA
GAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAATTTCTGTGGTTCATTAGCTCAGAGAACTATCTA
ATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACACCAGGAGACATTTATGTACATGCTGATCTTCAT
GGAGCTACTAGCTGTGTAATTAAGAATCCAACAGAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATT
CCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATT
CCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCG
CCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAG
CCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACA
CCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGG
CAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTA

>In-frame_ENST00000298310_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(amino acids)=787AA_start in transcript=450_stop in transcript=2813
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSA
KQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTY
EEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTESFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAI
PPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPST

--------------------------------------------------------------
>In-frame_ENST00000545773_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(transcript)=3521nt_BP=1686nt
GAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCA
TTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACC
TTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGA
ATATGATGCCGTCTAGTTTTGCCATGAAGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTG
ATGAGGCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGT
TGACTGAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAAC
ACTGTCTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGC
AGAAAGCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAG
CAGATAAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTG
AATCATTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCAT
TGAAGAAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGC
TCATAGAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGT
TAATTGTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGC
TAAGAAATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAG
GAAAAAAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCAT
ATGCCAATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGT
CAGCAGAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAAT
TTCTGTGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACAC
CAGGAGACATTTATGTACATGCTGATCTTCATGGAGCTACTAGCTGTGTAATTAAGAATCCAACAGAGTCTTTCTTTAGTTCATGTGGTA
GTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAA
ATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTG
CATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAG
AACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGT
GTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTG
CTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTT
CGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGG
TATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTG
ATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGG
ATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCAC
TGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGT
ATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAA
CTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGG
CACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGAT
GTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTT
TTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAA
TTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACT
GAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGA
GTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCA
AAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAACAAGATTAATAAATCACCCCAGTCTTA

>In-frame_ENST00000545773_ENST00000216373_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(amino acids)=745AA_start in transcript=68_stop in transcript=2305
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKGNIVLTDYEYVIL
NILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDI
EKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKA
LQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQ
TNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVE
AAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTE
SFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPP
PVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPP

--------------------------------------------------------------
>In-frame_ENST00000545773_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(transcript)=2340nt_BP=1686nt
GAGGAGAAGTGGCGTCGAGTCCGGCCGGGCAGTAGAGGAACTTGCGGTAGTGACCCTCGGGCCTCGCCATGAAGAGCCGCTTTAGCACCA
TTGACCTCCGCGCCGTACTCGCGGAGCTGAATGCTAGCTTGCTAGGAATGAGAGTAAACAATGTTTATGATGTGGATAATAAGACATACC
TTATTCGTCTTCAAAAACCGGACTTTAAAGCTACACTTTTACTTGAATCTGGCATACGAATTCATACAACAGAATTTGAGTGGCCTAAGA
ATATGATGCCGTCTAGTTTTGCCATGAAGGGGAACATTGTTCTTACAGATTATGAGTACGTAATTTTAAATATTCTAAGGTTTCGAACTG
ATGAGGCAGATGATGTTAAATTTGCTGTTCGTGAACGCTATCCACTTGATCATGCTAGAGCTGCTGAACCTTTGCTTACTTTGGAAAGGT
TGACTGAAATAGTAGCCAGCGCACCTAAGGGTGAACTACTGAAGAGGGTGCTTAACCCATTACTTCCCTATGGACCAGCTCTCATTGAAC
ACTGTCTTTTAGAAAATGGATTCTCGGGTAATGTCAAAGTGGATGAAAAACTTGAAACTAAAGATATTGAAAAAGTACTTGTTTCTCTGC
AGAAAGCAGAAGACTATATGAAAACAACATCCAACTTCAGTGGGAAGGGATATATCATTCAGAAAAGAGAAATAAAACCAAGCTTGGAAG
CAGATAAACCAGTTGAAGACATACTGACGTATGAGGAATTTCATCCTTTCTTGTTTTCTCAACATTCACAATGTCCATATATAGAATTTG
AATCATTTGACAAGGCGGTGGATGAATTTTATTCCAAGATAGAAGGCCAGAAAATTGACTTAAAAGCTTTACAACAGGAAAAGCAAGCAT
TGAAGAAATTAGATAATGTTCGAAAGGATCACGAAAACAGATTGGAAGCTCTTCAGCAGGCTCAGGAAATAGACAAACTGAAAGGAGAGC
TCATAGAAATGAACCTACAAATAGTTGACAGAGCCATTCAGGTAGTTCGAAGTGCTTTAGCTAACCAGATAGATTGGACAGAAATTGGGT
TAATTGTGAAAGAAGCCCAGGCTCAAGGAGACCCTGTTGCAAGTGCAATCAAAGAATTAAAACTACAAACAAACCATGTTACAATGCTGC
TAAGAAATCCATACTTGTTATCAGAGGAGGAAGATGATGATGTTGATGGTGACGTCAATGTTGAGAAAAATGAAACTGAACCACCAAAAG
GAAAAAAGAAAAAACAAAAGAATAAACAGCTGCAGAAGCCTCAGAAAAATAAGCCCTTACTTGTAGATGTTGATCTCAGCTTGTCAGCAT
ATGCCAATGCCAAAAAGTATTATGATCACAAGAGATATGCTGCTAAGAAAACACAAAAGACTGTTGAAGCTGCTGAGAAGGCATTCAAGT
CAGCAGAAAAGAAAACAAAGCAAACATTAAAAGAAGTTCAGACTGTTACCTCTATTCAAAAAGCAAGAAAAGTATATTGGTTTGAGAAAT
TTCTGTGGTTCATTAGCTCAGAGAACTATCTAATTATAGGTGGACGAGATCAGCAACAGAATGAAATAATTGTGAAAAGATACTTGACAC
CAGGAGACATTTATGTACATGCTGATCTTCATGGAGCTACTAGCTGTGTAATTAAGAATCCAACAGAGTCTTTCTTTAGTTCATGTGGTA
GTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAA
ATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTG
CATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAG
AACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGT
GTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTG
CTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTT
CGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGG

>In-frame_ENST00000545773_ENST00000543680_TCGA-MP-A4TI-01A_NEMF_chr14_50280706_-_SOS2_chr14_50587102_length(amino acids)=745AA_start in transcript=68_stop in transcript=2305
MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKGNIVLTDYEYVIL
NILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDI
EKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKA
LQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQ
TNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVE
AAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTE
SFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPP
PVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NEMF-SOS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NEMF-SOS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NEMF-SOS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEMFC1510586Autism Spectrum Disorders1CTD_human
TgeneSOS2C0028326Noonan Syndrome4CLINGEN;GENOMICS_ENGLAND;ORPHANET
TgeneSOS2C4225282NOONAN SYNDROME 92CTD_human;GENOMICS_ENGLAND;UNIPROT