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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEO1-YWHAE (FusionGDB2 ID:58275)

Fusion Gene Summary for NEO1-YWHAE

check button Fusion gene summary
Fusion gene informationFusion gene name: NEO1-YWHAE
Fusion gene ID: 58275
HgeneTgene
Gene symbol

NEO1

YWHAE

Gene ID

4756

7531

Gene nameneogenin 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
SynonymsIGDCC2|NGN|NTN1R214-3-3E|HEL2|KCIP-1|MDCR|MDS
Cytomap

15q24.1

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionneogeninimmunoglobulin superfamily DCC subclass member 2neogenin homolog 114-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine
Modification date2020031320200327
UniProtAcc

Q92859

P62258

Ensembl transtripts involved in fusion geneENST00000339362, ENST00000261908, 
ENST00000558964, ENST00000560262, 
ENST00000560352, 		ENST00000264335, 
ENST00000571732, ENST00000573026, 
ENST00000575977, ENST00000498643, 
Fusion gene scores* DoF score14 X 7 X 7=68625 X 13 X 12=3900
# samples 1532
** MAII scorelog2(15/686*10)=-2.19324607567693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3900*10)=-3.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEO1 [Title/Abstract] AND YWHAE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEO1(73470768)-YWHAE(1268352), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYWHAE

GO:0000165

MAPK cascade

12917326

TgeneYWHAE

GO:0034605

cellular response to heat

12917326

TgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

TgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

TgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

TgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

TgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

TgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

TgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across NEO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across YWHAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1428NEO1chr15

73470768

+YWHAEchr17

1268352

-


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Fusion Gene ORF analysis for NEO1-YWHAE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339362ENST00000264335NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-5UTRENST00000339362ENST00000571732NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000339362ENST00000573026NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000339362ENST00000575977NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000339362ENST00000498643NEO1chr15

73470768

+YWHAEchr17

1268352

-
In-frameENST00000261908ENST00000264335NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-5UTRENST00000261908ENST00000571732NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000261908ENST00000573026NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000261908ENST00000575977NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000261908ENST00000498643NEO1chr15

73470768

+YWHAEchr17

1268352

-
In-frameENST00000558964ENST00000264335NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-5UTRENST00000558964ENST00000571732NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000558964ENST00000573026NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000558964ENST00000575977NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000558964ENST00000498643NEO1chr15

73470768

+YWHAEchr17

1268352

-
In-frameENST00000560262ENST00000264335NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-5UTRENST00000560262ENST00000571732NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000560262ENST00000573026NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000560262ENST00000575977NEO1chr15

73470768

+YWHAEchr17

1268352

-
5CDS-intronENST00000560262ENST00000498643NEO1chr15

73470768

+YWHAEchr17

1268352

-
intron-3CDSENST00000560352ENST00000264335NEO1chr15

73470768

+YWHAEchr17

1268352

-
intron-5UTRENST00000560352ENST00000571732NEO1chr15

73470768

+YWHAEchr17

1268352

-
intron-intronENST00000560352ENST00000573026NEO1chr15

73470768

+YWHAEchr17

1268352

-
intron-intronENST00000560352ENST00000575977NEO1chr15

73470768

+YWHAEchr17

1268352

-
intron-intronENST00000560352ENST00000498643NEO1chr15

73470768

+YWHAEchr17

1268352

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339362NEO1chr1573470768+ENST00000264335YWHAEchr171268352-361717382672441724
ENST00000261908NEO1chr1573470768+ENST00000264335YWHAEchr171268352-33621483122186724
ENST00000558964NEO1chr1573470768+ENST00000264335YWHAEchr171268352-32361357302060676
ENST00000560262NEO1chr1573470768+ENST00000264335YWHAEchr171268352-32361357302060676

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339362ENST00000264335NEO1chr1573470768+YWHAEchr171268352-0.0010101430.9989899
ENST00000261908ENST00000264335NEO1chr1573470768+YWHAEchr171268352-0.0009183160.99908173
ENST00000558964ENST00000264335NEO1chr1573470768+YWHAEchr171268352-0.0007901140.9992099
ENST00000560262ENST00000264335NEO1chr1573470768+YWHAEchr171268352-0.0007901140.9992099

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Fusion Genomic Features for NEO1-YWHAE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEO1-YWHAE


check button Go to

FGviewer for the breakpoints of chr15:73470768-chr17:1268352

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEO1

Q92859

YWHAE

P62258

FUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729152_238430.33333333333331462.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729243_336430.33333333333331462.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729341_426430.33333333333331462.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+72952_141430.33333333333331462.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830152_238430.33333333333331462.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830243_336430.33333333333331462.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830341_426430.33333333333331462.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+83052_141430.33333333333331462.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728152_238430.33333333333331451.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728243_336430.33333333333331451.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728341_426430.33333333333331451.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+72852_141430.33333333333331451.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728152_238430.33333333333331409.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728243_336430.33333333333331409.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728341_426430.33333333333331409.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+72852_141430.33333333333331409.0DomainNote=Ig-like C2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+7291118_1121430.33333333333331462.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+8301118_1121430.33333333333331462.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+7281118_1121430.33333333333331451.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+7281118_1121430.33333333333331409.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729441_535430.33333333333331462.0DomainFibronectin type-III 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729541_631430.33333333333331462.0DomainFibronectin type-III 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729636_731430.33333333333331462.0DomainFibronectin type-III 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729741_831430.33333333333331462.0DomainFibronectin type-III 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729856_952430.33333333333331462.0DomainFibronectin type-III 5
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+729957_1054430.33333333333331462.0DomainFibronectin type-III 6
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830441_535430.33333333333331462.0DomainFibronectin type-III 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830541_631430.33333333333331462.0DomainFibronectin type-III 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830636_731430.33333333333331462.0DomainFibronectin type-III 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830741_831430.33333333333331462.0DomainFibronectin type-III 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830856_952430.33333333333331462.0DomainFibronectin type-III 5
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+830957_1054430.33333333333331462.0DomainFibronectin type-III 6
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728441_535430.33333333333331451.0DomainFibronectin type-III 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728541_631430.33333333333331451.0DomainFibronectin type-III 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728636_731430.33333333333331451.0DomainFibronectin type-III 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728741_831430.33333333333331451.0DomainFibronectin type-III 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728856_952430.33333333333331451.0DomainFibronectin type-III 5
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+728957_1054430.33333333333331451.0DomainFibronectin type-III 6
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728441_535430.33333333333331409.0DomainFibronectin type-III 1
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728541_631430.33333333333331409.0DomainFibronectin type-III 2
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728636_731430.33333333333331409.0DomainFibronectin type-III 3
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728741_831430.33333333333331409.0DomainFibronectin type-III 4
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728856_952430.33333333333331409.0DomainFibronectin type-III 5
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+728957_1054430.33333333333331409.0DomainFibronectin type-III 6
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+7291127_1461430.33333333333331462.0Topological domainCytoplasmic
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+72934_1105430.33333333333331462.0Topological domainExtracellular
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+8301127_1461430.33333333333331462.0Topological domainCytoplasmic
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+83034_1105430.33333333333331462.0Topological domainExtracellular
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+7281127_1461430.33333333333331451.0Topological domainCytoplasmic
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+72834_1105430.33333333333331451.0Topological domainExtracellular
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+7281127_1461430.33333333333331409.0Topological domainCytoplasmic
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+72834_1105430.33333333333331409.0Topological domainExtracellular
HgeneNEO1chr15:73470768chr17:1268352ENST00000261908+7291106_1126430.33333333333331462.0TransmembraneHelical
HgeneNEO1chr15:73470768chr17:1268352ENST00000339362+8301106_1126430.33333333333331462.0TransmembraneHelical
HgeneNEO1chr15:73470768chr17:1268352ENST00000558964+7281106_1126430.33333333333331451.0TransmembraneHelical
HgeneNEO1chr15:73470768chr17:1268352ENST00000560262+7281106_1126430.33333333333331409.0TransmembraneHelical


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Fusion Gene Sequence for NEO1-YWHAE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000339362_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(transcript)=3617nt_BP=1738nt
GGTCAGCGGCTGCGCGGCCGGCCCCCTCCCACGGGAGCCGCGCCAGGGCCCAGCAAGAGTCGGGCGGGATCGCTATTGTTTTTGGCGAGC
ACATAAATCCCCGGGCCGACCCACTGCGCACCCAGGTTTCCTCCCGGAGGCCTTTCGGTTTCCTCTGAGGCCCTATATAGAGGCTCCAGG
CCCGGACTGTGCAGAGGTGCGCGCCCACGCCGGCCTCCCGGACCAGCCTGAGCTCGGAGCGCCTCTCGCCCTCAGGAGGGAGGCGCCCTG
GAGTCTCCCCTCCAGCGAGAGGGGCTGCGCGGGCCGGGCCGGGCCGGGCTGGGCTGGAGCAGCGGCGGCCGCGGGAGCCGAGCTTGCAGC
GAGGGACCGGCTGAGGCGCGCGGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATG
GCGGCGGAGCGGGGAGCCCGGCGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCC
GCGGCCGCCAGGAGCGGCTCCGCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGAT
ACACTCTCAGTTAGAGGCTCTTCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACT
TTTTTAAACTTAGTATCAGATGATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAA
CCTGATGAAGGTTATTATCAGTGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTT
CCAAGATTTACCAGCCAACCAGAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCA
TTTGTGAGGTGGGAACAGAACAGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCA
ACTGAAGGAGATGGCGGGCTTTATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCA
GATCCTGAGGTGATATCAGACTTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTT
GCTTCAGGACTTCCTACTCCAACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCA
GGTGGTAGCCTGGAGATCAGTGATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCT
CAAGCAGAGCTTACAGTGCAAGCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCACGAATCTATGGATATTGTATTTGAA
TGTGAAGTGACTGGAAAACCAACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTATTTTAAGATTGTAAAG
GAACATAATCTTCAAGTTTTGGGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTTGGAAATGCACAAGCT
GGAGCCCAACTGATAATCCTTGAACATGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGA
AACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAAC
AAGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGAT
GTACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTG
GCAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAA
CTTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGC
AGGTTGGCAAAAGCAGCTTTTGATGATGCAATTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCTACACTTATCATGCAG
TTGTTACGTGATAATCTGACACTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGAC
GAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCAC
TGAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTC
AAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGG
CTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTA
TAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTG
TTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGT
AAAAAATGTTTCCAACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACT
TTACTCTCCCACTGAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCT
CCCCCTACCTCCTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTAC
TGGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAACTTAAATAAAACAAA
CCTAAATTAAAAATGCCAAATATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAGTCCAAACACACTGACAGTATTATGTTT
GCCTGAATGTGAAACATTCCTCCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATGTATGTTTTGGAAAAAAATTGCCTGTAG
TCTGGTTGTGAAGAACACTGAGTCAGTTGATGGTGTGTCTTGTCCTCCAGACCAGGCAGCAACATGGTATTTATTTTAATCATTAAAGTA

>In-frame_ENST00000339362_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(amino acids)=724AA_start in transcript=267_stop in transcript=2441
MESPLQREGLRGPGRAGLGWSSGGRGSRACSEGPAEARGREGGKGSAALSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPG
AAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN
ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIV
KEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEE
NKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMT
ELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVE

--------------------------------------------------------------
>In-frame_ENST00000261908_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(transcript)=3362nt_BP=1483nt
GAGGGAGGCGCCCTGGAGTCTCCCCTCCAGCGAGAGGGGCTGCGCGGGCCGGGCCGGGCCGGGCTGGGCTGGAGCAGCGGCGGCCGCGGG
AGCCGAGCTTGCAGCGAGGGACCGGCTGAGGCGCGCGGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACT
CTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGGCGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGC
CGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCCGCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTG
GTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCTTCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGG
AAAAAAGATGGAACTTTTTTAAACTTAGTATCAGATGATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCAT
TCCAAACACAATAAACCTGATGAAGGTTATTATCAGTGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTC
ATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCAGAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAAT
GCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAACAGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTG
GTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTTTATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAA
TTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGACTTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTA
GTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCAACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGA
TTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGTGATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAAT
GAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAAGCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCACGAATCTATG
GATATTGTATTTGAATGTGAAGTGACTGGAAAACCAACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTAT
TTTAAGATTGTAAAGGAACATAATCTTCAAGTTTTGGGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTT
GGAAATGCACAAGCTGGAGCCCAACTGATAATCCTTGAACATGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTG
ACAGTTGAAGAAAGAAACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAA
CAGAAAGAAGAAAACAAGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGT
TGTGACATTCTGGATGTACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGAC
TACCACAGGTATCTGGCAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGAT
ATTGCAATGACAGAACTTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCC
CCTGACCGTGCCTGCAGGTTGGCAAAAGCAGCTTTTGATGATGCAATTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCT
ACACTTATCATGCAGTTGTTACGTGATAATCTGACACTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTG
CAGGACGTGGAAGACGAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAA
ACTCCCCATTGTCACTGAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTT
TTTTAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAAC
AGGACTACATAGAGGCTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGA
AAGCCATTAGACTTATAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTA
ATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTG
TAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGC
TCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTT
CTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAA
GCTAATTTGTACTACTGGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAA
CTTAAATAAAACAAACCTAAATTAAAAATGCCAAATATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAGTCCAAACACACT
GACAGTATTATGTTTGCCTGAATGTGAAACATTCCTCCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATGTATGTTTTGGAA
AAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGAGTCAGTTGATGGTGTGTCTTGTCCTCCAGACCAGGCAGCAACATGGTATTTATT

>In-frame_ENST00000261908_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(amino acids)=724AA_start in transcript=12_stop in transcript=2186
MESPLQREGLRGPGRAGLGWSSGGRGSRACSEGPAEARGREGGKGSAALSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPG
AAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN
ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIV
KEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEE
NKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMT
ELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVE

--------------------------------------------------------------
>In-frame_ENST00000558964_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(transcript)=3236nt_BP=1357nt
GGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGG
CGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCC
GCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCT
TCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACTTTTTTAAACTTAGTATCAGAT
GATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAACCTGATGAAGGTTATTATCAG
TGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCA
GAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAAC
AGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTT
TATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGAC
TTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCA
ACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGT
GATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAA
GCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCACGAATCTATGGATATTGTATTTGAATGTGAAGTGACTGGAAAACCA
ACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTATTTTAAGATTGTAAAGGAACATAATCTTCAAGTTTTG
GGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTTGGAAATGCACAAGCTGGAGCCCAACTGATAATCCTT
GAACATGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAAACCTCCTATCTGTTGCATAT
AAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACAAGGGAGGAGAAGACAAGCTA
AAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATGTACTGGACAAACACCTCATT
CCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGGCAGAATTTGCCACAGGAAAC
GACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAACTTCCACCAACGCATCCTATT
CGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCAGGTTGGCAAAAGCAGCTTTT
GATGATGCAATTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCTACACTTATCATGCAGTTGTTACGTGATAATCTGACA
CTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGC
CAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAAATCTGACT
TTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAG
TGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTC
GTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAG
AGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAG
TAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGC
TGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGG
TTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCA
CTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCAC
AGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAACTTAAATAAAACAAACCTAAATTAAAAATGCCAAAT
ATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAGTCCAAACACACTGACAGTATTATGTTTGCCTGAATGTGAAACATTCCT
CCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATGTATGTTTTGGAAAAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGA

>In-frame_ENST00000558964_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(amino acids)=676AA_start in transcript=30_stop in transcript=2060
MSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYS
EPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNN
AILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPL
VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPT
NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHEMVESMKK
VAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKV
FYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTL

--------------------------------------------------------------
>In-frame_ENST00000560262_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(transcript)=3236nt_BP=1357nt
GGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGG
CGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCC
GCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCT
TCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACTTTTTTAAACTTAGTATCAGAT
GATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAACCTGATGAAGGTTATTATCAG
TGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCA
GAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAAC
AGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTT
TATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGAC
TTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCA
ACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGT
GATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAA
GCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCACGAATCTATGGATATTGTATTTGAATGTGAAGTGACTGGAAAACCA
ACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTATTTTAAGATTGTAAAGGAACATAATCTTCAAGTTTTG
GGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTTGGAAATGCACAAGCTGGAGCCCAACTGATAATCCTT
GAACATGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAAACCTCCTATCTGTTGCATAT
AAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACAAGGGAGGAGAAGACAAGCTA
AAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATGTACTGGACAAACACCTCATT
CCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGGCAGAATTTGCCACAGGAAAC
GACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAACTTCCACCAACGCATCCTATT
CGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCAGGTTGGCAAAAGCAGCTTTT
GATGATGCAATTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCTACACTTATCATGCAGTTGTTACGTGATAATCTGACA
CTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGC
CAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAAATCTGACT
TTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAG
TGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTC
GTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAG
AGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAG
TAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGC
TGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGG
TTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCA
CTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCAC
AGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAACTTAAATAAAACAAACCTAAATTAAAAATGCCAAAT
ATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAGTCCAAACACACTGACAGTATTATGTTTGCCTGAATGTGAAACATTCCT
CCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATGTATGTTTTGGAAAAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGA

>In-frame_ENST00000560262_ENST00000264335_TCGA-24-1428_NEO1_chr15_73470768_+_YWHAE_chr17_1268352_length(amino acids)=676AA_start in transcript=30_stop in transcript=2060
MSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYS
EPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNN
AILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPL
VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPT
NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHEMVESMKK
VAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKV
FYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NEO1-YWHAE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEO1-YWHAE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEO1-YWHAE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYWHAEC0036341Schizophrenia4PSYGENET
TgeneYWHAEC0005586Bipolar Disorder2PSYGENET
TgeneYWHAEC0206630Endometrial Stromal Sarcoma2ORPHANET
TgeneYWHAEC0027627Neoplasm Metastasis1CTD_human
TgeneYWHAEC0265219Miller Dieker syndrome1ORPHANET
TgeneYWHAEC0334488Clear cell sarcoma of kidney1ORPHANET
TgeneYWHAEC2750748Chromosome 17p13.3 Duplication Syndrome1ORPHANET
TgeneYWHAEC4707092Distal 17p13.3 microdeletion syndrome1ORPHANET