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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEU3-POLA2 (FusionGDB2 ID:58293)

Fusion Gene Summary for NEU3-POLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEU3-POLA2
Fusion gene ID: 58293
HgeneTgene
Gene symbol

NEU3

POLA2

Gene ID

10825

23649

Gene nameneuraminidase 3DNA polymerase alpha 2, accessory subunit
SynonymsSIAL3-
Cytomap

11q13.4

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionsialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidasemembrane sialidasesialidase 3 (membrane sialidase)DNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000294064, ENST00000531509, 
ENST00000544263, ENST00000529024, 
ENST00000532963, ENST00000531619, 
ENST00000545272, ENST00000526068, 
ENST00000534628, 		ENST00000265465, 
ENST00000541089, ENST00000534785, 
Fusion gene scores* DoF score4 X 5 X 2=4010 X 14 X 6=840
# samples 616
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEU3 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEU3(74705765)-POLA2(65043363), # samples:2
Anticipated loss of major functional domain due to fusion event.NEU3-POLA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NEU3-POLA2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NEU3-POLA2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEU3

GO:0005975

carbohydrate metabolic process

12730204

HgeneNEU3

GO:0006689

ganglioside catabolic process

10861246

HgeneNEU3

GO:0009313

oligosaccharide catabolic process

10861246


check buttonFusion gene breakpoints across NEU3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across POLA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A6FQ-01ANEU3chr11

74705765

+POLA2chr11

65043363

+
ChimerDB4BRCATCGA-LL-A6FQ-01ANEU3chr11

74705765

+POLA2chr11

65043363

+
ChimerDB4BRCATCGA-LL-A6FQ-01ANEU3chr11

74700199

+POLA2chr11

65043363

+


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Fusion Gene ORF analysis for NEU3-POLA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000294064ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000294064ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000294064ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000531509ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531509ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000531509ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000544263ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000544263ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000544263ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000529024ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000529024ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000529024ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000532963ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000532963ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000532963ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000531619ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531619ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000531619ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000545272ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000545272ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000545272ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000526068ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000526068ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000526068ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
Frame-shiftENST00000534628ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000534628ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000534628ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
Frame-shiftENST00000294064ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000294064ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000294064ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000531509ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531509ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000531509ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-3CDSENST00000544263ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-5UTRENST00000544263ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-intronENST00000544263ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000529024ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000529024ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000529024ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000532963ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000532963ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000532963ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000531619ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531619ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000531619ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-3CDSENST00000545272ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-5UTRENST00000545272ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5UTR-intronENST00000545272ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000526068ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000526068ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000526068ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+
Frame-shiftENST00000534628ENST00000265465NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-5UTRENST00000534628ENST00000541089NEU3chr11

74700199

+POLA2chr11

65043363

+
5CDS-intronENST00000534628ENST00000534785NEU3chr11

74700199

+POLA2chr11

65043363

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294064NEU3chr1174705765+ENST00000265465POLA2chr1165043363+409212336152675686
ENST00000531509NEU3chr1174705765+ENST00000265465POLA2chr1165043363+36557964152238607
ENST00000544263NEU3chr1174705765+ENST00000265465POLA2chr1165043363+3236377231819598
ENST00000531619NEU3chr1174705765+ENST00000265465POLA2chr1165043363+32834241181866582

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294064ENST00000265465NEU3chr1174705765+POLA2chr1165043363+0.0016897050.9983103
ENST00000531509ENST00000265465NEU3chr1174705765+POLA2chr1165043363+0.0019827770.9980172
ENST00000544263ENST00000265465NEU3chr1174705765+POLA2chr1165043363+0.0032190840.9967809
ENST00000531619ENST00000265465NEU3chr1174705765+POLA2chr1165043363+0.0030433710.9969566

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Fusion Genomic Features for NEU3-POLA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NEU3chr1174700199+POLA2chr1165043362+1.64E-060.99999833
NEU3chr1174705765+POLA2chr1165043362+1.49E-081
NEU3chr1174700199+POLA2chr1165043362+1.64E-060.99999833
NEU3chr1174705765+POLA2chr1165043362+1.49E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEU3-POLA2


check button Go to

FGviewer for the breakpoints of chr11:74705765-chr11:65043363

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+3424_2769.0429.0MotifNote=FRIP motif
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465318115_157118.0599.0Compositional biasNote=Pro/Ser/Thr-rich
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465318486_489118.0599.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34129_14069.0429.0RepeatNote=BNR 1
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34203_21469.0429.0RepeatNote=BNR 2
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34254_26569.0429.0RepeatNote=BNR 3
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465318101_107118.0599.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for NEU3-POLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000294064_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(transcript)=4092nt_BP=1233nt
TTTCCTTTTATTGGCGTTTGTAAAATTTCTTCTTTTTAAAATTGTTATATTTTAGAGACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTG
CAGTGGTGCAATCACAGCTCACCACAGCCTCCAACTCCTGGGCTCAAGGCATCCTCCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGG
CATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAAAAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTG
GGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCTATGTGACAAATCTATGTATGTAAATGTGTGTATAT
ACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGAGAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTG
TAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAAGCTTTAGGCGGTGATACCGAGCTACAGACCAATAT
AAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGGTGGGCCCAGGGCTTGAGCTGAGTTGGCGAGGGTGGAG
GTGGTGCCGGTCCCACGCCGTGGTGGGGACCGAGCTGCGGGCTGGAGGGAGGGGCAGCGCCGAGGGGGCGGGACGGGGAGGGCTCGCGGA
GTAGGCCAACGGTTGGCCCCAACCGCCACTGACTACAGCCTGCGCCCGCCTCTTTTCGTTGCCGTTACCTGTTTCCGGCAGTCGACACGC
TCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGGG
GCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCG
ACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGAT
GACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGG
AGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACC
CCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCC
TCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGA
GCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGA
GAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCA
CAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAA
CATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATC
AACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTT
GAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATC
AACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCA
TTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGA
GATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCC
GAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGT
TCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGAC
ATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTC
GTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGG
AGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCT
GCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAG
CCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAG
CTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTT
CTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATT
TATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCC
GGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAG
TGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATT
ACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCA
GAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAA
GGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTC
CCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAG
TCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTT
CACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAG
GCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGT
CTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCCA

>In-frame_ENST00000294064_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(amino acids)=686AA_start in transcript=615_stop in transcript=2675
MARVEVVPVPRRGGDRAAGWREGQRRGGGTGRARGVGQRLAPTATDYSLRPPLFVAVTCFRQSTRSSLLGACLRVLRLSCFSLSILLCLS
LPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAE
KRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSW
SGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVIL
EGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLD
LIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQ
VQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPS

--------------------------------------------------------------
>In-frame_ENST00000531509_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(transcript)=3655nt_BP=796nt
CCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGGCATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAA
AAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTGGGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCT
ATGTGACAAATCTATGTATGTAAATGTGTGTATATACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGA
GAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTGTAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAA
GCTTTAGGCGGTGATACCGAGCTACAGACCAATATAAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGTCT
CCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTC
CAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTT
CCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAA
GCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCG
AGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCC
AAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTC
TGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCT
CCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTT
GCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGA
GGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAAT
TATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGA
GGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCT
GATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCT
ACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGT
CCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGT
ACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGA
GGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCC
GCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGA
GCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCG
ACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCC
TCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGG
AGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTC
TCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAG
GCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCT
ATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCA
AGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTT
TTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATT
TGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTC
CTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGC
ATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGT
TCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAG
GCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGC
CCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGC
AAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATG

>In-frame_ENST00000531509_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(amino acids)=607AA_start in transcript=415_stop in transcript=2238
MKRGGGRWELSLPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYI
PPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVV
TSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDS
NGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTT
SDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFS
YSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQL

--------------------------------------------------------------
>In-frame_ENST00000544263_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(transcript)=3236nt_BP=377nt
AGAGAGGAGGCGGCCGTTGGGAACTGAGTCTCCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGC
CCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAG
TGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCC
CCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGA
TTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCC
ATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCT
CCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAA
CTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGG
AACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACG
GGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGG
AATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTG
TGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTG
ACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGG
ATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCA
CAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACT
CCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACAT
CCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCT
TGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTG
TCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTA
CCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTG
TGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCC
TGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTG
TGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTG
TGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCT
GAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTG
GAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCT
GACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTA
TCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGT
CCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTA
GAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCT
CCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTG
CCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCT
GTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCT
GTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAAC

>In-frame_ENST00000544263_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(amino acids)=598AA_start in transcript=23_stop in transcript=1819
MSLPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAF
AEKRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV
SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSV
ILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL
LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDK
KQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII

--------------------------------------------------------------
>In-frame_ENST00000531619_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(transcript)=3283nt_BP=424nt
CTCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGG
GGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCC
GACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGA
TGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAG
GAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTAC
CCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCC
CTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGG
AGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCG
AGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGC
ACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGA
ACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAAT
CAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTT
TGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCAT
CAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCC
ATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAG
AGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTC
CGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAG
TTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGA
CATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTT
CGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAG
GAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTC
TGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCA
GCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAA
GCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTT
TCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTAT
TTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCC
CGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTA
GTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCC
AGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAA
AGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCT
CCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGA
GTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGT
TCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCA
GGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTG
TCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCC

>In-frame_ENST00000531619_ENST00000265465_TCGA-LL-A6FQ-01A_NEU3_chr11_74705765_+_POLA2_chr11_65043363_length(amino acids)=582AA_start in transcript=118_stop in transcript=1866
MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLV
LRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVL
GCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPV
DLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCI
LFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSING
VIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NEU3-POLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEU3-POLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEU3-POLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource