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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NF1-TRMT61B (FusionGDB2 ID:58362)

Fusion Gene Summary for NF1-TRMT61B

check button Fusion gene summary
Fusion gene informationFusion gene name: NF1-TRMT61B
Fusion gene ID: 58362
HgeneTgene
Gene symbol

NF1

TRMT61B

Gene ID

4763

55006

Gene nameneurofibromin 1tRNA methyltransferase 61B
SynonymsNFNS|VRNF|WSS-
Cytomap

17q11.2

2p23.2

Type of geneprotein-codingprotein-coding
Descriptionneurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1tRNA (adenine(58)-N(1))-methyltransferase, mitochondrialmRNA methyladenosine-N(1)-methyltransferasepotential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61Bpotential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61Bt
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356175, ENST00000358273, 
ENST00000431387, ENST00000581113, 
ENST00000417592, ENST00000444181, 
ENST00000306108, ENST00000484060, 
Fusion gene scores* DoF score47 X 26 X 21=256621 X 1 X 1=1
# samples 691
** MAII scorelog2(69/25662*10)=-5.21689344093196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: NF1 [Title/Abstract] AND TRMT61B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNF1(29497015)-TRMT61B(29084174), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371

TgeneTRMT61B

GO:0051260

protein homooligomerization

23097428

TgeneTRMT61B

GO:0070901

mitochondrial tRNA methylation

23097428

TgeneTRMT61B

GO:0080009

mRNA methylation

29107537


check buttonFusion gene breakpoints across NF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRMT61B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-7643-01ANF1chr17

29497015

-TRMT61Bchr2

29084174

-


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Fusion Gene ORF analysis for NF1-TRMT61B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356175ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000356175ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-
In-frameENST00000358273ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000358273ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-
In-frameENST00000431387ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000431387ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-3CDSENST00000581113ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-5UTRENST00000581113ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-3CDSENST00000417592ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-5UTRENST00000417592ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-3CDSENST00000444181ENST00000306108NF1chr17

29497015

-TRMT61Bchr2

29084174

-
intron-5UTRENST00000444181ENST00000484060NF1chr17

29497015

-TRMT61Bchr2

29084174

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356175NF1chr1729497015-ENST00000306108TRMT61Bchr229084174-19799692541600448
ENST00000358273NF1chr1729497015-ENST00000306108TRMT61Bchr229084174-19799692541600448
ENST00000431387NF1chr1729497015-ENST00000306108TRMT61Bchr229084174-19299192041550448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356175ENST00000306108NF1chr1729497015-TRMT61Bchr229084174-0.0002445370.99975544
ENST00000358273ENST00000306108NF1chr1729497015-TRMT61Bchr229084174-0.0002445370.99975544
ENST00000431387ENST00000306108NF1chr1729497015-TRMT61Bchr229084174-0.0002239470.99977607

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Fusion Genomic Features for NF1-TRMT61B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NF1-TRMT61B


check button Go to

FGviewer for the breakpoints of chr17:29497015-chr2:29084174

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817278_279267.3333333333333478.0RegionS-adenosyl-L-methionine binding
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817334_337267.3333333333333478.0RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817358_365267.3333333333333478.0RegionSubstrate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNF1chr17:29497015chr2:29084174ENST00000356175-5571352_1355195.333333333333342819.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000358273-5581352_1355195.333333333333342840.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000431387-5151352_1355195.33333333333334594.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000356175-5571235_1451195.333333333333342819.0DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000356175-5571580_1738195.333333333333342819.0DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000358273-5581235_1451195.333333333333342840.0DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000358273-5581580_1738195.333333333333342840.0DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000431387-5151235_1451195.33333333333334594.0DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000431387-5151580_1738195.33333333333334594.0DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000356175-5572555_2571195.333333333333342819.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000358273-5582555_2571195.333333333333342840.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000431387-5152555_2571195.33333333333334594.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000356175-5571580_1837195.333333333333342819.0RegionNote=Lipid binding
HgeneNF1chr17:29497015chr2:29084174ENST00000358273-5581580_1837195.333333333333342840.0RegionNote=Lipid binding
HgeneNF1chr17:29497015chr2:29084174ENST00000431387-5151580_1837195.33333333333334594.0RegionNote=Lipid binding
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817133_179267.3333333333333478.0RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817206_207267.3333333333333478.0RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817228_232267.3333333333333478.0RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST0000030610817253_260267.3333333333333478.0RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST000003061081777_79267.3333333333333478.0RegionSubstrate


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Fusion Gene Sequence for NF1-TRMT61B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356175_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(transcript)=1979nt_BP=969nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCA
TAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAG
AGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGG
ATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACAC
AGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGG
TTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAA
TTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGAC
CAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAGGTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAA
CTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCACTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACT
TATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAACATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTC
TTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTTGGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAG

>In-frame_ENST00000356175_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(amino acids)=448AA_start in transcript=254_stop in transcript=1600
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWK
LSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVI

--------------------------------------------------------------
>In-frame_ENST00000358273_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(transcript)=1979nt_BP=969nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCA
TAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAG
AGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGG
ATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACAC
AGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGG
TTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAA
TTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGAC
CAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAGGTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAA
CTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCACTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACT
TATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAACATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTC
TTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTTGGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAG

>In-frame_ENST00000358273_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(amino acids)=448AA_start in transcript=254_stop in transcript=1600
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWK
LSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVI

--------------------------------------------------------------
>In-frame_ENST00000431387_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(transcript)=1929nt_BP=919nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTAC
AAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACC
GAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAG
CATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACACAGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCA
TGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCT
AAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCAT
TCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAG
GTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAACTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCA
CTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACTTATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAA
CATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTCTTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTT
GGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAGATTTGTCTTTCTTCAAGAAATTAGTTTTCTTTCCTTTATTTGATTGATGG

>In-frame_ENST00000431387_ENST00000306108_TCGA-FG-7643-01A_NF1_chr17_29497015_-_TRMT61B_chr2_29084174_length(amino acids)=448AA_start in transcript=204_stop in transcript=1550
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWK
LSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NF1-TRMT61B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NF1-TRMT61B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NF1-TRMT61B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF1C0027831Neurofibromatosis 144CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNF1C1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome10CLINGEN
HgeneNF1C0349639Juvenile Myelomonocytic Leukemia7CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNF1C2931482Neurofibromatosis-Noonan syndrome6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNF1C0553586Cafe-au-lait macules with pulmonary stenosis5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNF1C0162678Neurofibromatoses3CGI;CTD_human;GENOMICS_ENGLAND
HgeneNF1C0004114Astrocytoma2CTD_human
HgeneNF1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneNF1C0025202melanoma2CGI;CTD_human
HgeneNF1C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneNF1C0205768Subependymal Giant Cell Astrocytoma2CTD_human
HgeneNF1C0206727Nerve Sheath Tumors2CTD_human
HgeneNF1C0280783Juvenile Pilocytic Astrocytoma2CTD_human
HgeneNF1C0280785Diffuse Astrocytoma2CTD_human
HgeneNF1C0334579Anaplastic astrocytoma2CTD_human
HgeneNF1C0334580Protoplasmic astrocytoma2CTD_human
HgeneNF1C0334581Gemistocytic astrocytoma2CTD_human
HgeneNF1C0334582Fibrillary Astrocytoma2CTD_human
HgeneNF1C0334583Pilocytic Astrocytoma2CTD_human
HgeneNF1C0338070Childhood Cerebral Astrocytoma2CTD_human
HgeneNF1C0547065Mixed oligoastrocytoma2CTD_human
HgeneNF1C0750935Cerebral Astrocytoma2CTD_human
HgeneNF1C0750936Intracranial Astrocytoma2CTD_human
HgeneNF1C0751689Peripheral Nerve Sheath Neoplasm2CTD_human
HgeneNF1C0751691Perineurioma2CTD_human
HgeneNF1C1704230Grade I Astrocytoma2CTD_human
HgeneNF1C1834235NEUROFIBROMATOSIS, FAMILIAL SPINAL2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNF1C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneNF1C0001430Adenoma1CTD_human
HgeneNF1C0004352Autistic Disorder1CTD_human
HgeneNF1C0016057Fibrosarcoma1CTD_human
HgeneNF1C0017636Glioblastoma1CTD_human
HgeneNF1C0017638Glioma1CGI;CTD_human
HgeneNF1C0020796Profound Mental Retardation1CTD_human
HgeneNF1C0023186Learning Disorders1CTD_human
HgeneNF1C0023827liposarcoma1CTD_human
HgeneNF1C0025363Mental Retardation, Psychosocial1CTD_human
HgeneNF1C0026654Moyamoya Disease1GENOMICS_ENGLAND
HgeneNF1C0027809Neurilemmoma1CTD_human
HgeneNF1C0027830neurofibroma1CTD_human
HgeneNF1C0027962Melanocytic nevus1CTD_human
HgeneNF1C0028326Noonan Syndrome1GENOMICS_ENGLAND
HgeneNF1C0031511Pheochromocytoma1CTD_human
HgeneNF1C0035320Retinal Neovascularization1CTD_human
HgeneNF1C0205646Adenoma, Basal Cell1CTD_human
HgeneNF1C0205647Follicular adenoma1CTD_human
HgeneNF1C0205648Adenoma, Microcystic1CTD_human
HgeneNF1C0205649Adenoma, Monomorphic1CTD_human
HgeneNF1C0205650Papillary adenoma1CTD_human
HgeneNF1C0205651Adenoma, Trabecular1CTD_human
HgeneNF1C0205824Liposarcoma, Dedifferentiated1CTD_human
HgeneNF1C0205825Liposarcoma, Pleomorphic1CTD_human
HgeneNF1C0205944Sarcoma, Epithelioid1CTD_human
HgeneNF1C0205945Sarcoma, Spindle Cell1CTD_human
HgeneNF1C0259783mixed gliomas1CTD_human
HgeneNF1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNF1C0555198Malignant Glioma1CTD_human
HgeneNF1C0751262Adult Learning Disorders1CTD_human
HgeneNF1C0751263Learning Disturbance1CTD_human
HgeneNF1C0751265Learning Disabilities1CTD_human
HgeneNF1C0751374Schwannomatosis, Plexiform1CTD_human
HgeneNF1C0917816Mental deficiency1CTD_human
HgeneNF1C0917817Neurofibromatosis 31CTD_human
HgeneNF1C1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneNF1C1261473Sarcoma1CTD_human
HgeneNF1C1330966Developmental Academic Disorder1CTD_human
HgeneNF1C1370889Liposarcoma, well differentiated1CTD_human
HgeneNF1C1621958Glioblastoma Multiforme1CTD_human
HgeneNF1C3150928NF1 Microdeletion Syndrome1ORPHANET
HgeneNF1C3714756Intellectual Disability1CTD_human