FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NFRKB-CRTAM (FusionGDB2 ID:58636)

Fusion Gene Summary for NFRKB-CRTAM

check button Fusion gene summary
Fusion gene informationFusion gene name: NFRKB-CRTAM
Fusion gene ID: 58636
HgeneTgene
Gene symbol

NFRKB

CRTAM

Gene ID

4798

56253

Gene namenuclear factor related to kappaB binding proteincytotoxic and regulatory T cell molecule
SynonymsINO80GCD355
Cytomap

11q24.3

11q24.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor related to kappa-B-binding proteinDNA-binding protein R kappa BINO80 complex subunit Gcytotoxic and regulatory T-cell moleculeclass-I MHC-restricted T-cell-associated molecule
Modification date2020031320200313
UniProtAcc

Q6P4R8

O95727

Ensembl transtripts involved in fusion geneENST00000446488, ENST00000304521, 
ENST00000524794, ENST00000524746, 
ENST00000526940, 		ENST00000227348, 
ENST00000533709, 
Fusion gene scores* DoF score6 X 7 X 6=2521 X 1 X 1=1
# samples 71
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: NFRKB [Title/Abstract] AND CRTAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFRKB(129746616)-CRTAM(122720776), # samples:1
Anticipated loss of major functional domain due to fusion event.NFRKB-CRTAM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NFRKB-CRTAM seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRTAM

GO:0001913

T cell mediated cytotoxicity

15811952

TgeneCRTAM

GO:0002355

detection of tumor cell

15811952

TgeneCRTAM

GO:0002860

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

15811952

TgeneCRTAM

GO:0008037

cell recognition

15811952

TgeneCRTAM

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

15811952

TgeneCRTAM

GO:0050715

positive regulation of cytokine secretion

15811952

TgeneCRTAM

GO:0050798

activated T cell proliferation

15811952

TgeneCRTAM

GO:0051606

detection of stimulus

15811952


check buttonFusion gene breakpoints across NFRKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CRTAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-XD-AAUI-01ANFRKBchr11

129746616

-CRTAMchr11

122720776

+


Top

Fusion Gene ORF analysis for NFRKB-CRTAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000446488ENST00000227348NFRKBchr11

129746616

-CRTAMchr11

122720776

+
5CDS-intronENST00000446488ENST00000533709NFRKBchr11

129746616

-CRTAMchr11

122720776

+
In-frameENST00000304521ENST00000227348NFRKBchr11

129746616

-CRTAMchr11

122720776

+
5CDS-intronENST00000304521ENST00000533709NFRKBchr11

129746616

-CRTAMchr11

122720776

+
In-frameENST00000524794ENST00000227348NFRKBchr11

129746616

-CRTAMchr11

122720776

+
5CDS-intronENST00000524794ENST00000533709NFRKBchr11

129746616

-CRTAMchr11

122720776

+
Frame-shiftENST00000524746ENST00000227348NFRKBchr11

129746616

-CRTAMchr11

122720776

+
5CDS-intronENST00000524746ENST00000533709NFRKBchr11

129746616

-CRTAMchr11

122720776

+
intron-3CDSENST00000526940ENST00000227348NFRKBchr11

129746616

-CRTAMchr11

122720776

+
intron-intronENST00000526940ENST00000533709NFRKBchr11

129746616

-CRTAMchr11

122720776

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000446488NFRKBchr11129746616-ENST00000227348CRTAMchr11122720776+42271851682986972
ENST00000304521NFRKBchr11129746616-ENST00000227348CRTAMchr11122720776+42831907463042998
ENST00000524794NFRKBchr11129746616-ENST00000227348CRTAMchr11122720776+431919434630781010

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000446488ENST00000227348NFRKBchr11129746616-CRTAMchr11122720776+0.0003440970.99965596
ENST00000304521ENST00000227348NFRKBchr11129746616-CRTAMchr11122720776+0.0010791720.9989208
ENST00000524794ENST00000227348NFRKBchr11129746616-CRTAMchr11122720776+0.0009821540.99901783

Top

Fusion Genomic Features for NFRKB-CRTAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFRKBchr11129746615-CRTAMchr11122720775+0.0001235210.9998765
NFRKBchr11129746615-CRTAMchr11122720775+0.0001235210.9998765

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NFRKB-CRTAM


check button Go to

FGviewer for the breakpoints of chr11:129746616-chr11:122720776

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFRKB

Q6P4R8

CRTAM

O95727

FUNCTION: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.FUNCTION: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-1525309_327582.33333333333341300.0Compositional biasNote=Lys-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-1626309_327582.33333333333341300.0Compositional biasNote=Lys-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-1727309_327582.33333333333341300.0Compositional biasNote=Lys-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-1525309_327607.33333333333341325.0Compositional biasNote=Lys-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-152539_156582.33333333333341300.0DomainDEUBAD
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-162639_156582.33333333333341300.0DomainDEUBAD
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-172739_156582.33333333333341300.0DomainDEUBAD
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-152539_156607.33333333333341325.0DomainDEUBAD
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-1525370_495582.33333333333341300.0RegionNote=Winged-helix like domain
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-1626370_495582.33333333333341300.0RegionNote=Winged-helix like domain
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-1727370_495582.33333333333341300.0RegionNote=Winged-helix like domain
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-1525370_495607.33333333333341325.0RegionNote=Winged-helix like domain
TgeneCRTAMchr11:129746616chr11:122720776ENST00000227348010118_21015.333333333333334394.0DomainIg-like C2-type
TgeneCRTAMchr11:129746616chr11:122720776ENST0000022734801018_11415.333333333333334394.0DomainIg-like V-type
TgeneCRTAMchr11:129746616chr11:122720776ENST0000053370905118_2100195.0DomainIg-like C2-type
TgeneCRTAMchr11:129746616chr11:122720776ENST000005337090518_1140195.0DomainIg-like V-type
TgeneCRTAMchr11:129746616chr11:122720776ENST00000227348010390_39315.333333333333334394.0MotifPDZ-binding
TgeneCRTAMchr11:129746616chr11:122720776ENST0000053370905390_3930195.0MotifPDZ-binding
TgeneCRTAMchr11:129746616chr11:122720776ENST0000022734801018_28715.333333333333334394.0Topological domainExtracellular
TgeneCRTAMchr11:129746616chr11:122720776ENST00000227348010309_39315.333333333333334394.0Topological domainCytoplasmic
TgeneCRTAMchr11:129746616chr11:122720776ENST000005337090518_2870195.0Topological domainExtracellular
TgeneCRTAMchr11:129746616chr11:122720776ENST0000053370905309_3930195.0Topological domainCytoplasmic
TgeneCRTAMchr11:129746616chr11:122720776ENST00000227348010288_30815.333333333333334394.0TransmembraneHelical
TgeneCRTAMchr11:129746616chr11:122720776ENST0000053370905288_3080195.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-15251245_1271582.33333333333341300.0Compositional biasNote=Gln-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-1525665_672582.33333333333341300.0Compositional biasNote=Poly-Ala
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-1525684_803582.33333333333341300.0Compositional biasNote=Ser-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000304521-1525716_739582.33333333333341300.0Compositional biasNote=Pro-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-16261245_1271582.33333333333341300.0Compositional biasNote=Gln-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-1626665_672582.33333333333341300.0Compositional biasNote=Poly-Ala
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-1626684_803582.33333333333341300.0Compositional biasNote=Ser-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000446488-1626716_739582.33333333333341300.0Compositional biasNote=Pro-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-17271245_1271582.33333333333341300.0Compositional biasNote=Gln-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-1727665_672582.33333333333341300.0Compositional biasNote=Poly-Ala
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-1727684_803582.33333333333341300.0Compositional biasNote=Ser-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524746-1727716_739582.33333333333341300.0Compositional biasNote=Pro-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-15251245_1271607.33333333333341325.0Compositional biasNote=Gln-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-1525665_672607.33333333333341325.0Compositional biasNote=Poly-Ala
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-1525684_803607.33333333333341325.0Compositional biasNote=Ser-rich
HgeneNFRKBchr11:129746616chr11:122720776ENST00000524794-1525716_739607.33333333333341325.0Compositional biasNote=Pro-rich


Top

Fusion Gene Sequence for NFRKB-CRTAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000446488_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(transcript)=4227nt_BP=1851nt
CAGGATTCCAGAATTGGAAATAACGGGAGGGAGGACCTGGTCCAGCTTCCCTTCCTCAAATAAGGAAATTGACACCTGGCGTGAGTACCT
GTGGAGAAGAAACAATGGATTCCTTAGACCATATGCTGACAGATCCTCTGGAACTTGGTCCGTGTGGAGATGGCCATGGCACGCGCATCA
TGGAGGATTGCCTCCTGGGAGGCACCAGAGTTAGTCTGCCCGAGGACCTTCTGGAGGATCCTGAGATCTTCTTTGATGTTGTCAGCCTCT
CAACATGGCAGGAAGTGTTAAGTGATTCTCAACGTGAACACCTCCAGCAGTTTCTGCCCCAGTTTCCTGAAGACAGTGCTGAGCAGCAGA
ATGAACTCATCTTAGCCTTGTTCAGTGGGGAGAACTTCCGCTTTGGAAACCCTCTGCACATTGCCCAGAAGCTTTTCCGAGACGGACACT
TTAACCCCGAGGTGGTCAAGTACCGGCAGTTATGCTTCAAGTCACAGTACAAGCGCTACCTCAACTCCCAGCAGCAGTATTTCCATCGGC
TGCTGAAGCAAATTCTTGCTTCCCGGAGTGATCTGCTGGAGATGGCCCGGCGGAGTGGCCCCGCCCTTCCCTTCCGGCAGAAACGCCCTT
CACCATCCCGCACACCTGAGGAGCGGGAGTGGCGGACCCAGCAGCGCTACTTGAAGGTCTTAAGGGAAGTGAAAGAGGAGTGTGGTGACA
CAGCCCTGTCATCTGATGAAGAGGATCTCAGCTCATGGCTTCCGAGCTCTCCAGCACGTTCTCCTAGTCCTGCGGTGCCCCTGCGGGTGG
TGCCCACACTTTCAACCACGGATATGAAAACTGCAGATAAAGTAGAACTGGGGGACAGTGACCTGAAGATAATGTTAAAGAAGCACCACG
AGAAGCGGAAACATCAGCCAGATCACCCGGACCTTTTGACAGGGGACCTGACTCTCAATGACATCATGACTCGAGTAAATGCTGGCAGGA
AGGGCTCTCTGGCAGCCTTATATGACTTGGCTGTCCTTAAAAAAAAGGTTAAGGAAAAAGAGGAAAAGAAGAAGAAGAAAATAAAAACGA
TCAAATCAGAGGCAGAGGACCTGGCCGAGCCGCTAAGCAGTACTGAAGGGGTCGCACCTCTCTCACAGGCCCCCTCTCCGCTGGCAATTC
CTGCTATCAAGGAAGAGCCCCTTGAAGACCTCAAGCCTTGCCTTGGAATCAATGAAATATCTTCCAGCTTCTTCTCTCTTCTATTAGAGA
TCTTGCTGCTGGAGAGTCAGGCTAGCCTTCCTATGCTAGAGGAGCGAGTTTTGGATTGGCAGTCATCGCCAGCCAGCTCCCTCAACAGCT
GGTTCTCTGCGGCCCCCAACTGGGCTGAGTTGGTACTACCAGCCCTGCAGTATCTTGCTGGAGAAAGTCGAGCTGTTCCTTCCAGTTTCT
CTCCATTTGTTGAATTCAAAGAGAAAACCCAGCAGTGGAAGTTGCTTGGCCAATCCCAAGATAATGAAAAGGAATTAGCTGCCCTCTTCC
AGCTATGGCTAGAGACCAAAGATCAGGCCTTCTGTAAGCAAGAAAATGAAGACAGCTCAGATGCCACAACACCTGTCCCTCGGGTAAGAA
CTGACTATGTGGTGCGTCCCAGCACGGGGGAGGAGAAACGGGTTTTTCAGGAGCAGGAGCGTTACAGGTATAGCCAACCCCATAAGGCGT
TCACCTTTCGCATGCACGGCTTTGAGTCTGTGGTGGGGCCAGTGAAGGGCGTGTTTGACAAGGAGACCTCGCTCAACAAGGCTCGGGAGC
ACTCCCTGCTGCGCTCCGACCGGCCTGCCTACGTCACCATTCTGTCTCTTGAGGCCTCTCTGACTAACCACACAGAAACCATCACCGTGG
AGGAAGGCCAGACGCTCACTCTAAAGTGTGTCACTTCTCTGAGGAAGAACTCCTCCCTCCAGTGGCTGACCCCCTCAGGGTTCACCATTT
TTTTAAATGAGTATCCTGCTTTAAAAAATTCCAAATACCAGCTTCTTCATCACTCGGCCAATCAGCTCTCCATCACTGTGCCTAACGTAA
CCCTGCAAGATGAAGGCGTGTACAAGTGCTTACATTACAGCGACTCTGTAAGCACAAAGGAAGTGAAAGTGATTGTGCTGGCAACTCCTT
TCAAGCCAATCCTGGAAGCTTCAGTTATCAGAAAGCAAAATGGAGAAGAACATGTTGTACTCATGTGCTCCACCATGAGAAGCAAGCCCC
CTCCGCAGATAACCTGGCTACTTGGGAATAGCATGGAAGTGTCCGGTGGAACGCTCCATGAATTTGAAACTGATGGGAAGAAATGTAATA
CTACCAGCACTCTCATAATCCACACTTATGGCAAAAATTCAACGGTGGACTGCATTATCCGACACAGAGGCCTGCAAGGGAGAAAACTAG
TAGCACCCTTCCGGTTTGAAGATTTGGTTACTGATGAAGAGACAGCTTCAGATGCTCTGGAGAGAAACTCTCTATCCTCTCAAGACCCAC
AGCAGCCCACCAGTACTGTCTCAGTAACGGAAGATTCTAGTACATCGGAGATTGACAAGGAAGAGAAAGAACAAACCACTCAAGATCCTG
ACTTGACCACCGAAGCAAATCCTCAGTATTTAGGACTGGCAAGAAAGAAAAGTGGCATCCTGCTGCTCACGCTGGTGTCCTTCCTCATTT
TCATACTCTTCATCATAGTCCAGCTCTTCATCATGAAGCTGAGGAAAGCACATGTGATATGGAAGAAAGAAAACGAAGTTTCAGAACACA
CACTAGAAAGTTACAGATCAAGGTCAAATAATGAAGAAACATCATCTGAAGAGAAAAATGGCCAATCTTCCCACCCTATGCGTTGCATGA
ACTACATCACAAAGTTGTACTCAGAAGCAAAAACAAAGAGGAAGGAAAATGTACAACATTCAAAATTAGAAGAAAAGCACATCCAAGTAC
CAGAGAGTATTGTGTAGTGCTCTCTGCAATGGAACATGTGATTTCAGGGTTGCCGCAGTGTCACCTCAGTGGACCAGCCTGGGGGAAGGA
GCTTAATTGCTGAGACATTAATAATGACCTCTTAGTGCAATGCAAGATGGTGTCCTCGGATAATGATCTGCCCCGGAGCTAGGGCAGCAA
CATGAGGACCAAACCATGCACATAAAGCTTGTAGTTTAAAAAAGAAAAGCAAAAAAATAATTATGCCTGACACTACTTCAGAGCAGGAGG
ATTCTACGAAGCCTTGGGGATCAGGGTCAGTGTGAGCAGCTAACATCCTACCTCAAATGGAACAGGATTTTTTGATGCTTTGCTCTAATG
GAACTGTTTAAAAAATTTTTTTTTCTTTTTAATATTTTCTTCTGGTCACAAAATAAAGAAATTTGGGATGCAAAGTACCTAAAGATCTCT
GATCCTAAGAAGTTACTTCTGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGTAGGCAGATCACTTGAGG
TCAGGAGTTGGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTAGTGGTGCGCACCTG
TAGTCTCAGATACTTGGGAGGCTGAGGGTGGAGAATCGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGTCAAGATCTCACCACTGCACT
CCAGCCTGGGCAACAGAGGGAGACTCTGTCTCAAAAAAAAAGAAGTTACTTCCAAGACAGACTTTTAAGATGTAACCAGCACAAAGCAAT
GTCAGGGAGGAGTGATACATGACAATAAATGAGTCAGATGAGCAAGAAGGCCCCAGAACCCATGCCCCAAGGCACAAAGAGGAGCTCAGG
GTAGGCCCAAAGATTCGAATTCCTTAGATTACTAAATCACATGAGCGGACCTTGTCTGTCAGATAAGATTTTTACCTGGAAATTCCATGA
CCAATACATGTGCAAAAGAAAATGATGGGTTGAATTTACTGATTATTGACCTAATGGATGGCTTTTTAAAATGTTTTAATAAAAAGCAGA
ATAGATGTTTGTTTTTCTAGTGGTTATACCAAGTTATACTTCCTGTTTTCACGTGTGAAAGTAACATGGGACATGCCTTTCTTTTCCGAT

>In-frame_ENST00000446488_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(amino acids)=972AA_start in transcript=68_stop in transcript=2986
MTPGVSTCGEETMDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFP
EDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPAL
PFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLK
IMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQ
APSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGES
RAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYR
YSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWL
TPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMC
STMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERN
SLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKK

--------------------------------------------------------------
>In-frame_ENST00000304521_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(transcript)=4283nt_BP=1907nt
GCTGTTTAGCTGTAATTAGGGTGCAAGGATAAGGTGTAAGAACTGGCTGGAGGTTGAATGTTTTCCTGGAGGAGTGTTAGCATCAACTAG
ATCCCTGGAATTTCTGCCTTTCTGTCTCAAGATGCATGTCTTTGTCCAGAGTACCTGTGGAGAAGAAACAATGGATTCCTTAGACCATAT
GCTGACAGATCCTCTGGAACTTGGTCCGTGTGGAGATGGCCATGGCACGCGCATCATGGAGGATTGCCTCCTGGGAGGCACCAGAGTTAG
TCTGCCCGAGGACCTTCTGGAGGATCCTGAGATCTTCTTTGATGTTGTCAGCCTCTCAACATGGCAGGAAGTGTTAAGTGATTCTCAACG
TGAACACCTCCAGCAGTTTCTGCCCCAGTTTCCTGAAGACAGTGCTGAGCAGCAGAATGAACTCATCTTAGCCTTGTTCAGTGGGGAGAA
CTTCCGCTTTGGAAACCCTCTGCACATTGCCCAGAAGCTTTTCCGAGACGGACACTTTAACCCCGAGGTGGTCAAGTACCGGCAGTTATG
CTTCAAGTCACAGTACAAGCGCTACCTCAACTCCCAGCAGCAGTATTTCCATCGGCTGCTGAAGCAAATTCTTGCTTCCCGGAGTGATCT
GCTGGAGATGGCCCGGCGGAGTGGCCCCGCCCTTCCCTTCCGGCAGAAACGCCCTTCACCATCCCGCACACCTGAGGAGCGGGAGTGGCG
GACCCAGCAGCGCTACTTGAAGGTCTTAAGGGAAGTGAAAGAGGAGTGTGGTGACACAGCCCTGTCATCTGATGAAGAGGATCTCAGCTC
ATGGCTTCCGAGCTCTCCAGCACGTTCTCCTAGTCCTGCGGTGCCCCTGCGGGTGGTGCCCACACTTTCAACCACGGATATGAAAACTGC
AGATAAAGTAGAACTGGGGGACAGTGACCTGAAGATAATGTTAAAGAAGCACCACGAGAAGCGGAAACATCAGCCAGATCACCCGGACCT
TTTGACAGGGGACCTGACTCTCAATGACATCATGACTCGAGTAAATGCTGGCAGGAAGGGCTCTCTGGCAGCCTTATATGACTTGGCTGT
CCTTAAAAAAAAGGTTAAGGAAAAAGAGGAAAAGAAGAAGAAGAAAATAAAAACGATCAAATCAGAGGCAGAGGACCTGGCCGAGCCGCT
AAGCAGTACTGAAGGGGTCGCACCTCTCTCACAGGCCCCCTCTCCGCTGGCAATTCCTGCTATCAAGGAAGAGCCCCTTGAAGACCTCAA
GCCTTGCCTTGGAATCAATGAAATATCTTCCAGCTTCTTCTCTCTTCTATTAGAGATCTTGCTGCTGGAGAGTCAGGCTAGCCTTCCTAT
GCTAGAGGAGCGAGTTTTGGATTGGCAGTCATCGCCAGCCAGCTCCCTCAACAGCTGGTTCTCTGCGGCCCCCAACTGGGCTGAGTTGGT
ACTACCAGCCCTGCAGTATCTTGCTGGAGAAAGTCGAGCTGTTCCTTCCAGTTTCTCTCCATTTGTTGAATTCAAAGAGAAAACCCAGCA
GTGGAAGTTGCTTGGCCAATCCCAAGATAATGAAAAGGAATTAGCTGCCCTCTTCCAGCTATGGCTAGAGACCAAAGATCAGGCCTTCTG
TAAGCAAGAAAATGAAGACAGCTCAGATGCCACAACACCTGTCCCTCGGGTAAGAACTGACTATGTGGTGCGTCCCAGCACGGGGGAGGA
GAAACGGGTTTTTCAGGAGCAGGAGCGTTACAGGTATAGCCAACCCCATAAGGCGTTCACCTTTCGCATGCACGGCTTTGAGTCTGTGGT
GGGGCCAGTGAAGGGCGTGTTTGACAAGGAGACCTCGCTCAACAAGGCTCGGGAGCACTCCCTGCTGCGCTCCGACCGGCCTGCCTACGT
CACCATTCTGTCTCTTGAGGCCTCTCTGACTAACCACACAGAAACCATCACCGTGGAGGAAGGCCAGACGCTCACTCTAAAGTGTGTCAC
TTCTCTGAGGAAGAACTCCTCCCTCCAGTGGCTGACCCCCTCAGGGTTCACCATTTTTTTAAATGAGTATCCTGCTTTAAAAAATTCCAA
ATACCAGCTTCTTCATCACTCGGCCAATCAGCTCTCCATCACTGTGCCTAACGTAACCCTGCAAGATGAAGGCGTGTACAAGTGCTTACA
TTACAGCGACTCTGTAAGCACAAAGGAAGTGAAAGTGATTGTGCTGGCAACTCCTTTCAAGCCAATCCTGGAAGCTTCAGTTATCAGAAA
GCAAAATGGAGAAGAACATGTTGTACTCATGTGCTCCACCATGAGAAGCAAGCCCCCTCCGCAGATAACCTGGCTACTTGGGAATAGCAT
GGAAGTGTCCGGTGGAACGCTCCATGAATTTGAAACTGATGGGAAGAAATGTAATACTACCAGCACTCTCATAATCCACACTTATGGCAA
AAATTCAACGGTGGACTGCATTATCCGACACAGAGGCCTGCAAGGGAGAAAACTAGTAGCACCCTTCCGGTTTGAAGATTTGGTTACTGA
TGAAGAGACAGCTTCAGATGCTCTGGAGAGAAACTCTCTATCCTCTCAAGACCCACAGCAGCCCACCAGTACTGTCTCAGTAACGGAAGA
TTCTAGTACATCGGAGATTGACAAGGAAGAGAAAGAACAAACCACTCAAGATCCTGACTTGACCACCGAAGCAAATCCTCAGTATTTAGG
ACTGGCAAGAAAGAAAAGTGGCATCCTGCTGCTCACGCTGGTGTCCTTCCTCATTTTCATACTCTTCATCATAGTCCAGCTCTTCATCAT
GAAGCTGAGGAAAGCACATGTGATATGGAAGAAAGAAAACGAAGTTTCAGAACACACACTAGAAAGTTACAGATCAAGGTCAAATAATGA
AGAAACATCATCTGAAGAGAAAAATGGCCAATCTTCCCACCCTATGCGTTGCATGAACTACATCACAAAGTTGTACTCAGAAGCAAAAAC
AAAGAGGAAGGAAAATGTACAACATTCAAAATTAGAAGAAAAGCACATCCAAGTACCAGAGAGTATTGTGTAGTGCTCTCTGCAATGGAA
CATGTGATTTCAGGGTTGCCGCAGTGTCACCTCAGTGGACCAGCCTGGGGGAAGGAGCTTAATTGCTGAGACATTAATAATGACCTCTTA
GTGCAATGCAAGATGGTGTCCTCGGATAATGATCTGCCCCGGAGCTAGGGCAGCAACATGAGGACCAAACCATGCACATAAAGCTTGTAG
TTTAAAAAAGAAAAGCAAAAAAATAATTATGCCTGACACTACTTCAGAGCAGGAGGATTCTACGAAGCCTTGGGGATCAGGGTCAGTGTG
AGCAGCTAACATCCTACCTCAAATGGAACAGGATTTTTTGATGCTTTGCTCTAATGGAACTGTTTAAAAAATTTTTTTTTCTTTTTAATA
TTTTCTTCTGGTCACAAAATAAAGAAATTTGGGATGCAAAGTACCTAAAGATCTCTGATCCTAAGAAGTTACTTCTGGCCAGGCGCGGTG
GCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGTAGGCAGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGGCCAACATAGTG
AAACCCCGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTAGTGGTGCGCACCTGTAGTCTCAGATACTTGGGAGGCTGAGGGTGGAGA
ATCGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGTCAAGATCTCACCACTGCACTCCAGCCTGGGCAACAGAGGGAGACTCTGTCTCAA
AAAAAAAGAAGTTACTTCCAAGACAGACTTTTAAGATGTAACCAGCACAAAGCAATGTCAGGGAGGAGTGATACATGACAATAAATGAGT
CAGATGAGCAAGAAGGCCCCAGAACCCATGCCCCAAGGCACAAAGAGGAGCTCAGGGTAGGCCCAAAGATTCGAATTCCTTAGATTACTA
AATCACATGAGCGGACCTTGTCTGTCAGATAAGATTTTTACCTGGAAATTCCATGACCAATACATGTGCAAAAGAAAATGATGGGTTGAA
TTTACTGATTATTGACCTAATGGATGGCTTTTTAAAATGTTTTAATAAAAAGCAGAATAGATGTTTGTTTTTCTAGTGGTTATACCAAGT
TATACTTCCTGTTTTCACGTGTGAAAGTAACATGGGACATGCCTTTCTTTTCCGATCAGTTTATTTAAGCTATACAGCAAACTTTGGCAT

>In-frame_ENST00000304521_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(amino acids)=998AA_start in transcript=46_stop in transcript=3042
MEVECFPGGVLASTRSLEFLPFCLKMHVFVQSTCGEETMDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDV
VSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQY
FHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVP
LRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKK
IKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASS
LNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVP
RVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLEASLTNHTET
ITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVL
ATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQG
RKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVS
FLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKH

--------------------------------------------------------------
>In-frame_ENST00000524794_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(transcript)=4319nt_BP=1943nt
GCTGTTTAGCTGTAATTAGGGTGCAAGGATAAGGTGTAAGAACTGGCTGGAGGTTGAATGTTTTCCTGGAGGAGTGTTAGCATCAACTAG
ATCCCTGGAATTTCTGCCTTTCTGTCTCAAGATGCATGTCTTTGTCCAGAGTACCTGTGGAGAAGAAACAATGGATTCCTTAGACCATAT
GCTGACAGATCCTCTGGAACTTGGTCCGTGTGGAGATGGCCATGGCACGCGCATCATGGAGGATTGCCTCCTGGGAGGCACCAGAGTTAG
TCTGCCCGAGGACCTTCTGGAGGATCCTGAGATCTTCTTTGATGTTGTCAGCCTCTCAACATGGCAGGAAGTGTTAAGTGATTCTCAACG
TGAACACCTCCAGCAGTTTCTGCCCCAGTTTCCTGAAGACAGTGCTGAGCAGCAGAATGAACTCATCTTAGCCTTGTTCAGTGGGGAGAA
CTTCCGCTTTGGAAACCCTCTGCACATTGCCCAGAAGCTTTTCCGAGACGGACACTTTAACCCCGAGGTGGTCAAGTACCGGCAGTTATG
CTTCAAGTCACAGTACAAGCGCTACCTCAACTCCCAGCAGCAGTATTTCCATCGGCTGCTGAAGCAAATTCTTGCTTCCCGGAGTGATCT
GCTGGAGATGGCCCGGCGGAGTGGCCCCGCCCTTCCCTTCCGGCAGAAACGCCCTTCACCATCCCGCACACCTGAGGAGCGGGAGTGGCG
GACCCAGCAGCGCTACTTGAAGGTCTTAAGGGAAGTGAAAGAGGAGTGTGGTGACACAGCCCTGTCATCTGATGAAGAGGCCACGTTGGA
TTTACAAGAACAATTTTCTTTTGAAGATCTCAGCTCATGGCTTCCGAGCTCTCCAGCACGTTCTCCTAGTCCTGCGGTGCCCCTGCGGGT
GGTGCCCACACTTTCAACCACGGATATGAAAACTGCAGATAAAGTAGAACTGGGGGACAGTGACCTGAAGATAATGTTAAAGAAGCACCA
CGAGAAGCGGAAACATCAGCCAGATCACCCGGACCTTTTGACAGGGGACCTGACTCTCAATGACATCATGACTCGAGTAAATGCTGGCAG
GAAGGGCTCTCTGGCAGCCTTATATGACTTGGCTGTCCTTAAAAAAAAGGTTAAGGAAAAAGAGGAAAAGAAGAAGAAGAAAATAAAAAC
GATCAAATCAGAGGCAGAGGACCTGGCCGAGCCGCTAAGCAGTACTGAAGGGGTCGCACCTCTCTCACAGGCCCCCTCTCCGCTGGCAAT
TCCTGCTATCAAGGAAGAGCCCCTTGAAGACCTCAAGCCTTGCCTTGGAATCAATGAAATATCTTCCAGCTTCTTCTCTCTTCTATTAGA
GATCTTGCTGCTGGAGAGTCAGGCTAGCCTTCCTATGCTAGAGGAGCGAGTTTTGGATTGGCAGTCATCGCCAGCCAGCTCCCTCAACAG
CTGGTTCTCTGCGGCCCCCAACTGGGCTGAGTTGGTACTACCAGCCCTGCAGTATCTTGCTGGAGAAAGTCGAGCTGTTCCTTCCAGTTT
CTCTCCATTTGTTGAATTCAAAGAGAAAACCCAGCAGTGGAAGTTGCTTGGCCAATCCCAAGATAATGAAAAGGAATTAGCTGCCCTCTT
CCAGCTATGGCTAGAGACCAAAGATCAGGCCTTCTGTAAGCAAGAAAATGAAGACAGCTCAGATGCCACAACACCTGTCCCTCGGGTAAG
AACTGACTATGTGGTGCGTCCCAGCACGGGGGAGGAGAAACGGGTTTTTCAGGAGCAGGAGCGTTACAGGTATAGCCAACCCCATAAGGC
GTTCACCTTTCGCATGCACGGCTTTGAGTCTGTGGTGGGGCCAGTGAAGGGCGTGTTTGACAAGGAGACCTCGCTCAACAAGGCTCGGGA
GCACTCCCTGCTGCGCTCCGACCGGCCTGCCTACGTCACCATTCTGTCTCTTGAGGCCTCTCTGACTAACCACACAGAAACCATCACCGT
GGAGGAAGGCCAGACGCTCACTCTAAAGTGTGTCACTTCTCTGAGGAAGAACTCCTCCCTCCAGTGGCTGACCCCCTCAGGGTTCACCAT
TTTTTTAAATGAGTATCCTGCTTTAAAAAATTCCAAATACCAGCTTCTTCATCACTCGGCCAATCAGCTCTCCATCACTGTGCCTAACGT
AACCCTGCAAGATGAAGGCGTGTACAAGTGCTTACATTACAGCGACTCTGTAAGCACAAAGGAAGTGAAAGTGATTGTGCTGGCAACTCC
TTTCAAGCCAATCCTGGAAGCTTCAGTTATCAGAAAGCAAAATGGAGAAGAACATGTTGTACTCATGTGCTCCACCATGAGAAGCAAGCC
CCCTCCGCAGATAACCTGGCTACTTGGGAATAGCATGGAAGTGTCCGGTGGAACGCTCCATGAATTTGAAACTGATGGGAAGAAATGTAA
TACTACCAGCACTCTCATAATCCACACTTATGGCAAAAATTCAACGGTGGACTGCATTATCCGACACAGAGGCCTGCAAGGGAGAAAACT
AGTAGCACCCTTCCGGTTTGAAGATTTGGTTACTGATGAAGAGACAGCTTCAGATGCTCTGGAGAGAAACTCTCTATCCTCTCAAGACCC
ACAGCAGCCCACCAGTACTGTCTCAGTAACGGAAGATTCTAGTACATCGGAGATTGACAAGGAAGAGAAAGAACAAACCACTCAAGATCC
TGACTTGACCACCGAAGCAAATCCTCAGTATTTAGGACTGGCAAGAAAGAAAAGTGGCATCCTGCTGCTCACGCTGGTGTCCTTCCTCAT
TTTCATACTCTTCATCATAGTCCAGCTCTTCATCATGAAGCTGAGGAAAGCACATGTGATATGGAAGAAAGAAAACGAAGTTTCAGAACA
CACACTAGAAAGTTACAGATCAAGGTCAAATAATGAAGAAACATCATCTGAAGAGAAAAATGGCCAATCTTCCCACCCTATGCGTTGCAT
GAACTACATCACAAAGTTGTACTCAGAAGCAAAAACAAAGAGGAAGGAAAATGTACAACATTCAAAATTAGAAGAAAAGCACATCCAAGT
ACCAGAGAGTATTGTGTAGTGCTCTCTGCAATGGAACATGTGATTTCAGGGTTGCCGCAGTGTCACCTCAGTGGACCAGCCTGGGGGAAG
GAGCTTAATTGCTGAGACATTAATAATGACCTCTTAGTGCAATGCAAGATGGTGTCCTCGGATAATGATCTGCCCCGGAGCTAGGGCAGC
AACATGAGGACCAAACCATGCACATAAAGCTTGTAGTTTAAAAAAGAAAAGCAAAAAAATAATTATGCCTGACACTACTTCAGAGCAGGA
GGATTCTACGAAGCCTTGGGGATCAGGGTCAGTGTGAGCAGCTAACATCCTACCTCAAATGGAACAGGATTTTTTGATGCTTTGCTCTAA
TGGAACTGTTTAAAAAATTTTTTTTTCTTTTTAATATTTTCTTCTGGTCACAAAATAAAGAAATTTGGGATGCAAAGTACCTAAAGATCT
CTGATCCTAAGAAGTTACTTCTGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGTAGGCAGATCACTTGA
GGTCAGGAGTTGGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTAGTGGTGCGCACC
TGTAGTCTCAGATACTTGGGAGGCTGAGGGTGGAGAATCGCTTGAACCTGGGAGGTGGAGATTGCAGTGAGTCAAGATCTCACCACTGCA
CTCCAGCCTGGGCAACAGAGGGAGACTCTGTCTCAAAAAAAAAGAAGTTACTTCCAAGACAGACTTTTAAGATGTAACCAGCACAAAGCA
ATGTCAGGGAGGAGTGATACATGACAATAAATGAGTCAGATGAGCAAGAAGGCCCCAGAACCCATGCCCCAAGGCACAAAGAGGAGCTCA
GGGTAGGCCCAAAGATTCGAATTCCTTAGATTACTAAATCACATGAGCGGACCTTGTCTGTCAGATAAGATTTTTACCTGGAAATTCCAT
GACCAATACATGTGCAAAAGAAAATGATGGGTTGAATTTACTGATTATTGACCTAATGGATGGCTTTTTAAAATGTTTTAATAAAAAGCA
GAATAGATGTTTGTTTTTCTAGTGGTTATACCAAGTTATACTTCCTGTTTTCACGTGTGAAAGTAACATGGGACATGCCTTTCTTTTCCG

>In-frame_ENST00000524794_ENST00000227348_TCGA-XD-AAUI-01A_NFRKB_chr11_129746616_-_CRTAM_chr11_122720776_length(amino acids)=1010AA_start in transcript=46_stop in transcript=3078
MEVECFPGGVLASTRSLEFLPFCLKMHVFVQSTCGEETMDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDV
VSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQY
FHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEATLDLQEQFSFEDLSSWLP
SSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKK
KVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEE
RVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQE
NEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTIL
SLEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSD
SVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNST
VDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLAR
KKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NFRKB-CRTAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NFRKB-CRTAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NFRKB-CRTAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource