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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFYC-MYH11 (FusionGDB2 ID:58685)

Fusion Gene Summary for NFYC-MYH11

check button Fusion gene summary
Fusion gene informationFusion gene name: NFYC-MYH11
Fusion gene ID: 58685
HgeneTgene
Gene symbol

NFYC

MYH11

Gene ID

4802

4629

Gene namenuclear transcription factor Y subunit gammamyosin heavy chain 11
SynonymsCBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YCAAT4|FAA4|SMHC|SMMHC
Cytomap

1p34.2

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionnuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cnmyosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
Modification date2020031320200322
UniProtAcc.

P35749

Ensembl transtripts involved in fusion geneENST00000427410, ENST00000447388, 
ENST00000425457, ENST00000456393, 
ENST00000372654, ENST00000372653, 
ENST00000372652, ENST00000372651, 
ENST00000440226, ENST00000308733, 
ENST00000483091, 		ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000300036, ENST00000573908, 
Fusion gene scores* DoF score16 X 9 X 8=115244 X 55 X 10=24200
# samples 1862
** MAII scorelog2(18/1152*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(62/24200*10)=-5.28659502177508
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFYC [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFYC(41236435)-MYH11(15818178), # samples:1
Anticipated loss of major functional domain due to fusion event.NFYC-MYH11 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NFYC-MYH11 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NFYC-MYH11 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFYC

GO:0006355

regulation of transcription, DNA-templated

15243141


check buttonFusion gene breakpoints across NFYC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE835819NFYCchr1

41236435

+MYH11chr16

15818178

-


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Fusion Gene ORF analysis for NFYC-MYH11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000427410ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000427410ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000427410ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000427410ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000427410ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000447388ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000447388ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000447388ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000447388ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000447388ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000425457ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000425457ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000425457ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000425457ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000425457ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000456393ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000456393ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000456393ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000456393ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000456393ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372654ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372654ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372654ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372654ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000372654ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372653ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372653ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372653ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372653ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000372653ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372652ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372652ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372652ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372652ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000372652ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372651ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372651ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372651ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000372651ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000372651ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000440226ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000440226ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000440226ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000440226ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000440226ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000308733ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000308733ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000308733ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
Frame-shiftENST00000308733ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
5CDS-intronENST00000308733ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-
intron-3CDSENST00000483091ENST00000396324NFYCchr1

41236435

+MYH11chr16

15818178

-
intron-3CDSENST00000483091ENST00000452625NFYCchr1

41236435

+MYH11chr16

15818178

-
intron-3CDSENST00000483091ENST00000576790NFYCchr1

41236435

+MYH11chr16

15818178

-
intron-3CDSENST00000483091ENST00000300036NFYCchr1

41236435

+MYH11chr16

15818178

-
intron-intronENST00000483091ENST00000573908NFYCchr1

41236435

+MYH11chr16

15818178

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NFYC-MYH11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFYC-MYH11


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYH11

P35749

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NFYC-MYH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NFYC-MYH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFYC-MYH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFYC-MYH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYH11C4707243Familial thoracic aortic aneurysm and aortic dissection10CLINGEN;GENOMICS_ENGLAND
TgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneMYH11C0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
TgeneMYH11C0026998Acute Myeloid Leukemia, M12CTD_human
TgeneMYH11C1851504Aortic aneurysm, familial thoracic 42CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMYH11C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneMYH11C1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET