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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIPBL-ANKRD17 (FusionGDB2 ID:58830)

Fusion Gene Summary for NIPBL-ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPBL-ANKRD17
Fusion gene ID: 58830
HgeneTgene
Gene symbol

NIPBL

ANKRD17

Gene ID

25836

26057

Gene nameNIPBL cohesin loading factorankyrin repeat domain 17
SynonymsCDLS|CDLS1|IDN3|IDN3-B|Scc2GTAR|MASK2|NY-BR-16
Cytomap

5p13.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homologankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2020031320200313
UniProtAcc

Q6KC79

O75179

Ensembl transtripts involved in fusion geneENST00000282516, ENST00000448238, 
ENST00000504430, 		ENST00000358602, 
ENST00000509867, ENST00000330838, 
ENST00000514252, 
Fusion gene scores* DoF score26 X 13 X 16=540812 X 18 X 5=1080
# samples 4321
** MAII scorelog2(43/5408*10)=-3.65268658669272
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPBL [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPBL(37010327)-ANKRD17(74043250), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

HgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

HgeneNIPBL

GO:0071921

cohesin loading

22628566

TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check buttonFusion gene breakpoints across NIPBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKRD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0T1-01ANIPBLchr5

37010327

+ANKRD17chr4

74043250

-
ChimerDB4BRCATCGA-A2-A0T1-01ANIPBLchr5

37010327

+ANKRD17chr4

74043250

-
ChimerDB4BRCATCGA-A2-A0T1-01ANIPBLchr5

37010327

-ANKRD17chr4

74043250

-


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Fusion Gene ORF analysis for NIPBL-ANKRD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000282516ENST00000358602NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
In-frameENST00000282516ENST00000509867NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
In-frameENST00000282516ENST00000330838NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
5CDS-intronENST00000282516ENST00000514252NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
In-frameENST00000448238ENST00000358602NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
In-frameENST00000448238ENST00000509867NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
In-frameENST00000448238ENST00000330838NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
5CDS-intronENST00000448238ENST00000514252NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
intron-3CDSENST00000504430ENST00000358602NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
intron-3CDSENST00000504430ENST00000509867NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
intron-3CDSENST00000504430ENST00000330838NIPBLchr5

37010327

+ANKRD17chr4

74043250

-
intron-intronENST00000504430ENST00000514252NIPBLchr5

37010327

+ANKRD17chr4

74043250

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282516NIPBLchr537010327+ENST00000358602ANKRD17chr474043250-153335059499124773992
ENST00000282516NIPBLchr537010327+ENST00000509867ANKRD17chr474043250-130235059499124773992
ENST00000282516NIPBLchr537010327+ENST00000330838ANKRD17chr474043250-122705059499117243741
ENST00000448238NIPBLchr537010327+ENST00000358602ANKRD17chr474043250-153025028468124463992
ENST00000448238NIPBLchr537010327+ENST00000509867ANKRD17chr474043250-129925028468124463992
ENST00000448238NIPBLchr537010327+ENST00000330838ANKRD17chr474043250-122395028468116933741

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282516ENST00000358602NIPBLchr537010327+ANKRD17chr474043250-0.000431760.9995683
ENST00000282516ENST00000509867NIPBLchr537010327+ANKRD17chr474043250-0.0009636370.99903643
ENST00000282516ENST00000330838NIPBLchr537010327+ANKRD17chr474043250-0.000798140.99920183
ENST00000448238ENST00000358602NIPBLchr537010327+ANKRD17chr474043250-0.0004231060.99957687
ENST00000448238ENST00000509867NIPBLchr537010327+ANKRD17chr474043250-0.0009461650.9990538
ENST00000448238ENST00000330838NIPBLchr537010327+ANKRD17chr474043250-0.0007841330.99921584

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Fusion Genomic Features for NIPBL-ANKRD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NIPBL-ANKRD17


check button Go to

FGviewer for the breakpoints of chr5:37010327-chr4:74043250

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPBL

Q6KC79

ANKRD17

O75179

FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.FUNCTION: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+2147418_4621520.02805.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+2146418_4621520.02698.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+2147996_10091520.02805.0MotifPxVxL motif
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+2146996_10091520.02698.0MotifPxVxL motif
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331442_1526131.02353.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341442_1526131.02604.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331603_1700131.02353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331950_2106131.02353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331966_2033131.02353.0Compositional biasNote=Thr-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033858_1008131.02353.0Compositional biasNote=Gln-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341603_1700131.02604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341950_2106131.02604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341966_2033131.02604.0Compositional biasNote=Thr-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034858_1008131.02604.0Compositional biasNote=Gln-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331725_1789131.02353.0DomainKH
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341725_1789131.02604.0DomainKH
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331082_1111131.02353.0RepeatNote=ANK 16
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331115_1144131.02353.0RepeatNote=ANK 17
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331149_1178131.02353.0RepeatNote=ANK 18
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331182_1211131.02353.0RepeatNote=ANK 19
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331217_1246131.02353.0RepeatNote=ANK 20
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331251_1280131.02353.0RepeatNote=ANK 21
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331284_1313131.02353.0RepeatNote=ANK 22
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331319_1348131.02353.0RepeatNote=ANK 23
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331352_1381131.02353.0RepeatNote=ANK 24
TgeneANKRD17chr5:37010327chr4:74043250ENST000003308380331385_1414131.02353.0RepeatNote=ANK 25
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033233_262131.02353.0RepeatNote=ANK 1
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033266_295131.02353.0RepeatNote=ANK 2
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033300_329131.02353.0RepeatNote=ANK 3
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033333_362131.02353.0RepeatNote=ANK 4
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033366_395131.02353.0RepeatNote=ANK 5
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033400_429131.02353.0RepeatNote=ANK 6
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033433_462131.02353.0RepeatNote=ANK 7
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033466_495131.02353.0RepeatNote=ANK 8
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033499_528131.02353.0RepeatNote=ANK 9
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033533_562131.02353.0RepeatNote=ANK 10
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033563_592131.02353.0RepeatNote=ANK 11
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033596_625131.02353.0RepeatNote=ANK 12
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033629_658131.02353.0RepeatNote=ANK 13
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033663_692131.02353.0RepeatNote=ANK 14
TgeneANKRD17chr5:37010327chr4:74043250ENST00000330838033696_725131.02353.0RepeatNote=ANK 15
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341082_1111131.02604.0RepeatNote=ANK 16
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341115_1144131.02604.0RepeatNote=ANK 17
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341149_1178131.02604.0RepeatNote=ANK 18
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341182_1211131.02604.0RepeatNote=ANK 19
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341217_1246131.02604.0RepeatNote=ANK 20
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341251_1280131.02604.0RepeatNote=ANK 21
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341284_1313131.02604.0RepeatNote=ANK 22
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341319_1348131.02604.0RepeatNote=ANK 23
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341352_1381131.02604.0RepeatNote=ANK 24
TgeneANKRD17chr5:37010327chr4:74043250ENST000003586020341385_1414131.02604.0RepeatNote=ANK 25
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034233_262131.02604.0RepeatNote=ANK 1
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034266_295131.02604.0RepeatNote=ANK 2
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034300_329131.02604.0RepeatNote=ANK 3
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034333_362131.02604.0RepeatNote=ANK 4
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034366_395131.02604.0RepeatNote=ANK 5
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034400_429131.02604.0RepeatNote=ANK 6
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034433_462131.02604.0RepeatNote=ANK 7
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034466_495131.02604.0RepeatNote=ANK 8
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034499_528131.02604.0RepeatNote=ANK 9
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034533_562131.02604.0RepeatNote=ANK 10
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034563_592131.02604.0RepeatNote=ANK 11
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034596_625131.02604.0RepeatNote=ANK 12
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034629_658131.02604.0RepeatNote=ANK 13
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034663_692131.02604.0RepeatNote=ANK 14
TgeneANKRD17chr5:37010327chr4:74043250ENST00000358602034696_725131.02604.0RepeatNote=ANK 15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+21471767_18051520.02805.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+21471843_18811520.02805.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+21471945_19841520.02805.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+21472227_22671520.02805.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37010327chr4:74043250ENST00000282516+21472313_23511520.02805.0RepeatNote=HEAT 5
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+21461767_18051520.02698.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+21461843_18811520.02698.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+21461945_19841520.02698.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+21462227_22671520.02698.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37010327chr4:74043250ENST00000448238+21462313_23511520.02698.0RepeatNote=HEAT 5
TgeneANKRD17chr5:37010327chr4:74043250ENST0000033083803396_110131.02353.0Compositional biasNote=Gly-rich
TgeneANKRD17chr5:37010327chr4:74043250ENST0000035860203496_110131.02604.0Compositional biasNote=Gly-rich


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Fusion Gene Sequence for NIPBL-ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000282516_ENST00000358602_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=15333nt_BP=5059nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAGTGGAGTCTTTCATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTT
ATCAGGTACTGCTGATGGTGCAGACCTCAGGACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGG
AAAATTGTCCACGGCTGATGGTAAAGCCTTTGCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGC
TGCTGCTGCACTTACCCGTATGAGAGCTGAAAGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGG
AGATGTAAATGCTGTGCGAAAGTTACTCATTGAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTG
TTCTGCTGGATACTATGAGCTTGCACAGGTTTTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTT
AATGGCTGCTGCTAATGGAGGACATGTCAAAATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAA
TACAGCACTTACATATGCTTGTGCTGGAGGCTATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGA
AAATGGTCATACCCCTCTTATGGAAGCTGGAAGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATAC
GCATTCTAATGAATTTAAAGAGAGTGCCCTTACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGC
GGATCAAGAGCATAAAACAGATGAAATGCACACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGA
CAGCGGTGCCCAAGTGAACATGCCTGCTGATTCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTT
ACTTATTGAAAGAGGAGCTAGCCTGGAAGAGGTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAAT
GGTGGCATTACTTCTTGGTCAAGGAGCAAATATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGG
CTTTCTGGAAGTGGCAGACTTTCTAATTAAGGCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGG
TCATTTGGAGTTAGTTAAATACTTATTAGCTGCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTG
TGAAAATGGTCATACTGATGTAGCAGATGTCTTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAAT
GAAAGCTGCAAGAGCTGGTCATGTTTGTACTGTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCA
TACTGTACTGTCCCTGGCTTGTGCAGGGGGTCATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAA
AGATGGCTCAACTATGTTGATAGAAGCAGCAAAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTC
AGCCCCTCCACCAGATGTCACTCAGTTAACTCCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGT
TGTTCCACCTCAGGAGCCTGACAAACCACCTGCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCTGCTTCTAAACAAAAGTCCAG
CAGCCATTTGCCAGCAAACAGCCAGGATGTACAGGGTTACATCACCAATCAGTCTCCAGAGAGCATTGTAGAAGAGGCTCAGGGAAAGTT
AACAGAACTGGAACAGAGGATAAAAGAAGCCATAGAAAAGAATGCACAGCTGCAGTCCTTGGAACTGGCTCATGCTGACCAACTTACCAA
GGAGAAGATCGAGGAGCTCAACAAAACAAGGGAGGAACAAATTCAGAAGAAACAAAAGATTTTGGAGGAACTACAGAAAGTAGAACGAGA
GTTACAACTGAAAACTCAGCAGCAGCTAAAAAAGCAGTATCTAGAGGTTAAAGCTCAAAGAATTCAACTTCAGCAACAGCAGCAACAGTC
TTGCCAACACCTGGGATTACTAACTCCTGTTGGAGTTGGAGAGCAGCTTTCTGAGGGAGACTATGCACGGTTACAGCAAGTGGATCCTGT
TTTACTTAAAGATGAACCCCAGCAGACTGCTGCTCAGATGGGTTTTGCGCCAATCCAGCCTCTGGCGATGCCTCAAGCTTTGCCTCTGGC
GGCAGGTCCCTTGCCTCCAGGGTCCATCGCAAATCTTACAGAACTGCAAGGAGTGATAGTTGGACAGCCAGTACTGGGCCAAGCACAGTT
GGCAGGGCTGGGGCAAGGAATTCTGACAGAAACACAACAAGGGTTAATGGTAGCCAGCCCTGCTCAGACCCTCAATGACACGCTGGATGA
CATCATGGCAGCAGTCAGTGGAAGAGCATCTGCAATGTCAAACACTCCTACCCACAGTATTGCTGCATCCATTTCCCAACCTCAGACTCC
AACTCCAAGTCCTATCATCTCTCCTTCAGCCATGCTTCCTATCTACCCTGCCATTGATATTGATGCACAGACTGAGAGTAATCATGACAC
GGCACTAACACTTGCCTGTGCTGGTGGCCACGAGGAACTGGTACAAACACTGCTAGAGAGAGGAGCTAGTATAGAGCACCGAGACAAGAA
AGGTTTTACTCCACTCATCTTGGCTGCCACAGCTGGTCATGTTGGTGTTGTGGAAATATTGCTGGACAATGGTGCAGACATTGAAGCCCA
GTCTGAAAGAACCAAGGACACACCACTCTCCTTGGCTTGTTCTGGGGGAAGACAGGAGGTGGTGGAGCTATTGTTAGCTCGAGGGGCAAA
TAAAGAGCACAGGAATGTTTCTGATTACACACCTCTAAGTCTGGCTGCTTCTGGTGGCTATGTGAACATCATCAAAATATTACTAAATGC
AGGAGCTGAGATTAACTCTAGAACTGGTAGCAAATTGGGCATCTCTCCTCTGATGTTAGCAGCTATGAATGGGCATACAGCTGCTGTTAA
GCTCCTGTTAGACATGGGCTCTGACATAAATGCTCAGATAGAAACCAATCGGAACACTGCCCTTACTTTAGCCTGCTTCCAAGGAAGAAC
TGAAGTGGTTAGTCTTCTGCTTGATAGAAAAGCAAATGTTGAACACAGAGCTAAGACTGGTCTCACACCACTAATGGAAGCTGCCTCTGG
TGGATATGCGGAGGTGGGCCGAGTTCTTTTGGATAAAGGTGCTGATGTTAATGCCCCTCCAGTTCCCTCCTCAAGAGATACAGCTTTAAC
CATAGCAGCAGATAAAGGGCATTACAAATTCTGTGAGCTTCTTATTGGCAGGGGAGCTCATATTGATGTACGTAACAAGAAGGGGAACAC
TCCATTGTGGCTAGCAGCAAATGGTGGACACCTCGATGTGGTTCAGTTACTGGTGCAAGCAGGTGCAGATGTGGATGCAGCAGATAACCG
CAAGATAACTCCTCTTATGGCAGCATTTAGAAAGGGTCATGTGAAGGTGGTGCGCTACTTAGTCAAAGAAGTCAATCAGTTTCCATCAGA
TTCTGAATGTATGAGATACATAGCAACCATCACTGATAAGGAGATGCTGAAGAAGTGTCATCTTTGTATGGAGTCAATAGTACAAGCCAA
AGATAGACAGGCTGCTGAAGCAAACAAAAACGCCAGCATTTTGTTAGAGGAGTTAGACTTGGAAAAGTTAAGGGAAGAAAGTCGGAGGCT
GGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGAAGCCAA
AAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACCTCCAAG
TGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAACTACAAC
CAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATACAGTCA
GCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAGCGATGA
AAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCCATCAGT
TCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGACCAGTAA
TTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGGGCAAAA
GAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAGAGGAGG
CTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAATCACTAT
AAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCC
AAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAAT
TAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAAC
CATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCT
TGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGG
TCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAG
TGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTAC
AAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAAC
CACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTC
CCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTC
CGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCA
TTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAAT
GACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGG
ATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGT
GCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAG
TACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAG
CACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATC
AGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACC
TGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAA
CATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCT
TAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATC
ATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTAT
CAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGAT
TGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTC
ACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTT
TCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCAT
ATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGGT
GTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGATTCCTT
TTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTAGGCTTT
TTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTTAGCATT
TTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTTTAGTAC
TGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTACAATTG
TTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATGTGAGAT
ATGTACCTTCATATTCAGAAATCTGGATGTTTCCTTCATACATTAAACTATTAATAAGCATAACTTTTCTACTGGTGTAATTTAAGTATA
AAGTAAAATAATGGGCATTATCATTGGATGTTTCCCCACATTGGCTTTTAAAATACCCATCTTGCTTTCTTTTTGGTTTATTTGTAGCAA
GGCACATATAGAAGAAGAAATTTCTGGCTTTTCCATGTTGTTTTATTACCTTTTCTCACTTTTAAAACTAATACAGACTTATCTCCTCAC
TCCTTTTTCTCTCCTTACCTTTACCACTAATACCAGTAAAATTATCTTTCTGATAGTGAAAAGGTTCTGTCAAGATTTTCACTGTAATGG
CTGCTACAGAGATGGACCATCTTCATCATCACCAGTGGTTTCTTCTAATTATAAAATGTTTAAACTTTCTGAGAATTTAAAAAGCCACCA
CTGTTCCCAGTCAGCATATACAAGCTCTTAATATTCTGTTTATTAAATAATTCAATGTACTATTTTATATTGGATGATATTGATTCTTAA
CATTGGCTTTTCAGTCATCAACAGTCAACATAAAAATTTCAATTTTCAGTAATTTAGTGGAAAATATCTTATTTCTTTTTTCAATTTTAA
AGGCTTCCTGCTTTTTTACCCTTGTATATTATCAGTGAAAAGGATCAACAGTTAATTTGAGCCAAGTAATAAAAGAAATTCTGCATTTGT
CACGAAGACAATTTATGGTAGACAGATAAATACACAGATTACAGTGTAAAGTCTCCATTTAACCTGTTTATAAAAGATACAAGGCCACAC
TAAACTACTCAGTGGGATTTATATATTCCATCCACTTGAAACAATAAACAGTAATGTATCCAAGAAGATTATGTGTCCTACCCTGTCTCA
TGGAAAAATTAATTATATGGTTGAAATGTAAAAGAAAGTAAGCATAAAAATCGAGTAATGTATATATCAATTTGTCTTCTTTTTTTTTAA
TTAGACATAAAATTTCACACTGGTAAAACATAAAAACTAACTAAAATTCATATAAATCACCTAGAGTTGATGATATTAACATGGTTCCTT
GGTTGTCAAGTAAATCAAATGATTTCTTCCATCTGAGTAAAGAGTAAAGCCTGAGTAAAGAGTAAAAAGATGACTTCTCAAACATATCCA
GAAATTTGTAAACAGTACACTCATATCTTTTAGTTTAAGAAGTGGTCTTAAAATATATAAATTTGTTTTTCCACCTATGTTTAATATGCC
CAAATTTAAAGGGAGAGCTAAAAGACAGCCTACAAATAAATATAGCTATGAAATAAAATTATAGCACTTTACTAAAAAAGGGATGTAATA
ATGTTATTTAACGAAGTATTTTATATATGACTTGCCACTATTCTATACATAAAATTTTTTTTCTTAATTCTTTCCTGTGTTAACTAGGGT
TATTTTCTATTTAAGGTAATCCTGCTGGAGAACAGATGCTATCCAATATTTATTACAACACATGAGTTGTGTTGTTTCACAATACTGAAT
TTCTTAGGTGAGGTATTTTATTTAAAAAGGAGGGGGAAAACTCCTATATTTTCTTGACTTCAAACCTGTGGGGCCAGGGGATATAGATTG
AAATGCTCCGTATTTAGTCTTGGGGATCAGGCTTGTTTAGTACAATACCATGGTTTTAGAAGTCTGTACTAGGAACATTTTTAAAATACA
TTTTTTATATTTCAGATGTAATGCAGTGCACTTTTATTTGAACAATAAAAAAACCCATAACTTTTTGAGACCATGAAGGTCTTTTATTTT
TTAATTTTGAAAATATGTGGTATGTGTATATGCAGACTACATCATTGTTTTAAGAAATGATTTAACTCTTGGACATTACACTTGGGTTAG
TTCACACCTTAAATCCCCAAGTAGTTAATATCTCAATTATTGTATAATCAGTTTATACCATCCATTCCCAACAAAATTCCACATTTCATG
CCTTTTCAACATACATTTCAACATAATCAACATATTTACAAACACTGACTTCACTGTTTATAAAGAAGAAATTTCCCCTCCTATTTCCCA
TTACTGAAAAGTCAAGTCATTTTTATTGATACATGAAAATTAATTTTTTTGTAAATGACTACGTATAGTCATTTTTCTCCTTTGGAAAAG
GTAAATAGCTTATTAACTAATCCTGTCTTGTTCTTCACAAAAATAATAGTCCATCCGTGTTTTGACTCAAATAACCTAAATACACATTTT
GTAAAAATTTTGTACCCTATATTACTTATTTTTAAAACAGTACAGTGTTAGACTAAACAGGAAAACTCAAAGTTATAAAATCTCTTCAGA

>In-frame_ENST00000282516_ENST00000358602_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3992AA_start in transcript=499_stop in transcript=12477
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQK
KQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFA
PIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTP
THSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV
VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP
LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV
NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV
VRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKK
KEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENV
QIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKA
SIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDI
DKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATA
LTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSP
KPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPM
PTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRP
PLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRP
HSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSD
TSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQ
SVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGN
PMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIK

--------------------------------------------------------------
>In-frame_ENST00000282516_ENST00000509867_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=13023nt_BP=5059nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAGTGGAGTCTTTCATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTT
ATCAGGTACTGCTGATGGTGCAGACCTCAGGACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGG
AAAATTGTCCACGGCTGATGGTAAAGCCTTTGCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGC
TGCTGCTGCACTTACCCGTATGAGAGCTGAAAGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGG
AGATGTAAATGCTGTGCGAAAGTTACTCATTGAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTG
TTCTGCTGGATACTATGAGCTTGCACAGGTTTTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTT
AATGGCTGCTGCTAATGGAGGACATGTCAAAATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAA
TACAGCACTTACATATGCTTGTGCTGGAGGCTATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGA
AAATGGTCATACCCCTCTTATGGAAGCTGGAAGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATAC
GCATTCTAATGAATTTAAAGAGAGTGCCCTTACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGC
GGATCAAGAGCATAAAACAGATGAAATGCACACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGA
CAGCGGTGCCCAAGTGAACATGCCTGCTGATTCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTT
ACTTATTGAAAGAGGAGCTAGCCTGGAAGAGGTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAAT
GGTGGCATTACTTCTTGGTCAAGGAGCAAATATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGG
CTTTCTGGAAGTGGCAGACTTTCTAATTAAGGCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGG
TCATTTGGAGTTAGTTAAATACTTATTAGCTGCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTG
TGAAAATGGTCATACTGATGTAGCAGATGTCTTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAAT
GAAAGCTGCAAGAGCTGGTCATGTTTGTACTGTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCA
TACTGTACTGTCCCTGGCTTGTGCAGGGGGTCATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAA
AGATGGCTCAACTATGTTGATAGAAGCAGCAAAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTC
AGCCCCTCCACCAGATGTCACTCAGTTAACTCCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGT
TGTTCCACCTCAGGAGCCTGACAAACCACCTGCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCTGCTTCTAAACAAAAGTCCAG
CAGCCATTTGCCAGCAAACAGCCAGGATGTACAGGGTTACATCACCAATCAGTCTCCAGAGAGCATTGTAGAAGAGGCTCAGGGAAAGTT
AACAGAACTGGAACAGAGGATAAAAGAAGCCATAGAAAAGAATGCACAGCTGCAGTCCTTGGAACTGGCTCATGCTGACCAACTTACCAA
GGAGAAGATCGAGGAGCTCAACAAAACAAGGGAGGAACAAATTCAGAAGAAACAAAAGATTTTGGAGGAACTACAGAAAGTAGAACGAGA
GTTACAACTGAAAACTCAGCAGCAGCTAAAAAAGCAGTATCTAGAGGTTAAAGCTCAAAGAATTCAACTTCAGCAACAGCAGCAACAGTC
TTGCCAACACCTGGGATTACTAACTCCTGTTGGAGTTGGAGAGCAGCTTTCTGAGGGAGACTATGCACGGTTACAGCAAGTGGATCCTGT
TTTACTTAAAGATGAACCCCAGCAGACTGCTGCTCAGATGGGTTTTGCGCCAATCCAGCCTCTGGCGATGCCTCAAGCTTTGCCTCTGGC
GGCAGGTCCCTTGCCTCCAGGGTCCATCGCAAATCTTACAGAACTGCAAGGAGTGATAGTTGGACAGCCAGTACTGGGCCAAGCACAGTT
GGCAGGGCTGGGGCAAGGAATTCTGACAGAAACACAACAAGGGTTAATGGTAGCCAGCCCTGCTCAGACCCTCAATGACACGCTGGATGA
CATCATGGCAGCAGTCAGTGGAAGAGCATCTGCAATGTCAAACACTCCTACCCACAGTATTGCTGCATCCATTTCCCAACCTCAGACTCC
AACTCCAAGTCCTATCATCTCTCCTTCAGCCATGCTTCCTATCTACCCTGCCATTGATATTGATGCACAGACTGAGAGTAATCATGACAC
GGCACTAACACTTGCCTGTGCTGGTGGCCACGAGGAACTGGTACAAACACTGCTAGAGAGAGGAGCTAGTATAGAGCACCGAGACAAGAA
AGGTTTTACTCCACTCATCTTGGCTGCCACAGCTGGTCATGTTGGTGTTGTGGAAATATTGCTGGACAATGGTGCAGACATTGAAGCCCA
GTCTGAAAGAACCAAGGACACACCACTCTCCTTGGCTTGTTCTGGGGGAAGACAGGAGGTGGTGGAGCTATTGTTAGCTCGAGGGGCAAA
TAAAGAGCACAGGAATGTTTCTGATTACACACCTCTAAGTCTGGCTGCTTCTGGTGGCTATGTGAACATCATCAAAATATTACTAAATGC
AGGAGCTGAGATTAACTCTAGAACTGGTAGCAAATTGGGCATCTCTCCTCTGATGTTAGCAGCTATGAATGGGCATACAGCTGCTGTTAA
GCTCCTGTTAGACATGGGCTCTGACATAAATGCTCAGATAGAAACCAATCGGAACACTGCCCTTACTTTAGCCTGCTTCCAAGGAAGAAC
TGAAGTGGTTAGTCTTCTGCTTGATAGAAAAGCAAATGTTGAACACAGAGCTAAGACTGGTCTCACACCACTAATGGAAGCTGCCTCTGG
TGGATATGCGGAGGTGGGCCGAGTTCTTTTGGATAAAGGTGCTGATGTTAATGCCCCTCCAGTTCCCTCCTCAAGAGATACAGCTTTAAC
CATAGCAGCAGATAAAGGGCATTACAAATTCTGTGAGCTTCTTATTGGCAGGGGAGCTCATATTGATGTACGTAACAAGAAGGGGAACAC
TCCATTGTGGCTAGCAGCAAATGGTGGACACCTCGATGTGGTTCAGTTACTGGTGCAAGCAGGTGCAGATGTGGATGCAGCAGATAACCG
CAAGATAACTCCTCTTATGGCAGCATTTAGAAAGGGTCATGTGAAGGTGGTGCGCTACTTAGTCAAAGAAGTCAATCAGTTTCCATCAGA
TTCTGAATGTATGAGATACATAGCAACCATCACTGATAAGGAGATGCTGAAGAAGTGTCATCTTTGTATGGAGTCAATAGTACAAGCCAA
AGATAGACAGGCTGCTGAAGCAAACAAAAACGCCAGCATTTTGTTAGAGGAGTTAGACTTGGAAAAGTTAAGGGAAGAAAGTCGGAGGCT
GGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGAAGCCAA
AAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACCTCCAAG
TGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAACTACAAC
CAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATACAGTCA
GCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAGCGATGA
AAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCCATCAGT
TCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGACCAGTAA
TTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGGGCAAAA
GAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAGAGGAGG
CTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAATCACTAT
AAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCC
AAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAAT
TAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAAC
CATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCT
TGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGG
TCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAG
TGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTAC
AAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAAC
CACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTC
CCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTC
CGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCA
TTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAAT
GACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGG
ATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGT
GCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAG
TACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAG
CACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATC
AGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACC
TGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAA
CATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCT
TAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATC
ATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTAT
CAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGAT
TGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTC
ACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTT
TCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCAT
ATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGGT
GTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGATTCCTT
TTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTAGGCTTT
TTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTTAGCATT
TTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTTTAGTAC
TGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTACAATTG
TTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATGTGAGAT

>In-frame_ENST00000282516_ENST00000509867_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3992AA_start in transcript=499_stop in transcript=12477
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQK
KQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFA
PIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTP
THSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV
VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP
LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV
NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV
VRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKK
KEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENV
QIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKA
SIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDI
DKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATA
LTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSP
KPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPM
PTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRP
PLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRP
HSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSD
TSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQ
SVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGN
PMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIK

--------------------------------------------------------------
>In-frame_ENST00000282516_ENST00000330838_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=12270nt_BP=5059nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAGTGGAGTCTTTCATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTT
ATCAGGTACTGCTGATGGTGCAGACCTCAGGACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGG
AAAATTGTCCACGGCTGATGGTAAAGCCTTTGCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGC
TGCTGCTGCACTTACCCGTATGAGAGCTGAAAGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGG
AGATGTAAATGCTGTGCGAAAGTTACTCATTGAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTG
TTCTGCTGGATACTATGAGCTTGCACAGGTTTTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTT
AATGGCTGCTGCTAATGGAGGACATGTCAAAATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAA
TACAGCACTTACATATGCTTGTGCTGGAGGCTATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGA
AAATGGTCATACCCCTCTTATGGAAGCTGGAAGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATAC
GCATTCTAATGAATTTAAAGAGAGTGCCCTTACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGC
GGATCAAGAGCATAAAACAGATGAAATGCACACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGA
CAGCGGTGCCCAAGTGAACATGCCTGCTGATTCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTT
ACTTATTGAAAGAGGAGCTAGCCTGGAAGAGGTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAAT
GGTGGCATTACTTCTTGGTCAAGGAGCAAATATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGG
CTTTCTGGAAGTGGCAGACTTTCTAATTAAGGCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGG
TCATTTGGAGTTAGTTAAATACTTATTAGCTGCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTG
TGAAAATGGTCATACTGATGTAGCAGATGTCTTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAAT
GAAAGCTGCAAGAGCTGGTCATGTTTGTACTGTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCA
TACTGTACTGTCCCTGGCTTGTGCAGGGGGTCATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAA
AGATGGCTCAACTATGTTGATAGAAGCAGCAAAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTC
AGCCCCTCCACCAGATGTCACTCAGTTAACTCCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGT
TGTTCCACCTCAGGAGCCTGACAAACCACCTGCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCAGTCAGTGGAAGAGCATCTGC
AATGTCAAACACTCCTACCCACAGTATTGCTGCATCCATTTCCCAACCTCAGACTCCAACTCCAAGTCCTATCATCTCTCCTTCAGCCAT
GCTTCCTATCTACCCTGCCATTGATATTGATGCACAGACTGAGAGTAATCATGACACGGCACTAACACTTGCCTGTGCTGGTGGCCACGA
GGAACTGGTACAAACACTGCTAGAGAGAGGAGCTAGTATAGAGCACCGAGACAAGAAAGGTTTTACTCCACTCATCTTGGCTGCCACAGC
TGGTCATGTTGGTGTTGTGGAAATATTGCTGGACAATGGTGCAGACATTGAAGCCCAGTCTGAAAGAACCAAGGACACACCACTCTCCTT
GGCTTGTTCTGGGGGAAGACAGGAGGTGGTGGAGCTATTGTTAGCTCGAGGGGCAAATAAAGAGCACAGGAATGTTTCTGATTACACACC
TCTAAGTCTGGCTGCTTCTGGTGGCTATGTGAACATCATCAAAATATTACTAAATGCAGGAGCTGAGATTAACTCTAGAACTGGTAGCAA
ATTGGGCATCTCTCCTCTGATGTTAGCAGCTATGAATGGGCATACAGCTGCTGTTAAGCTCCTGTTAGACATGGGCTCTGACATAAATGC
TCAGATAGAAACCAATCGGAACACTGCCCTTACTTTAGCCTGCTTCCAAGGAAGAACTGAAGTGGTTAGTCTTCTGCTTGATAGAAAAGC
AAATGTTGAACACAGAGCTAAGACTGGTCTCACACCACTAATGGAAGCTGCCTCTGGTGGATATGCGGAGGTGGGCCGAGTTCTTTTGGA
TAAAGGTGCTGATGTTAATGCCCCTCCAGTTCCCTCCTCAAGAGATACAGCTTTAACCATAGCAGCAGATAAAGGGCATTACAAATTCTG
TGAGCTTCTTATTGGCAGGGGAGCTCATATTGATGTACGTAACAAGAAGGGGAACACTCCATTGTGGCTAGCAGCAAATGGTGGACACCT
CGATGTGGTTCAGTTACTGGTGCAAGCAGGTGCAGATGTGGATGCAGCAGATAACCGCAAGATAACTCCTCTTATGGCAGCATTTAGAAA
GGGTCATGTGAAGGTGGTGCGCTACTTAGTCAAAGAAGTCAATCAGTTTCCATCAGATTCTGAATGTATGAGATACATAGCAACCATCAC
TGATAAGGAGATGCTGAAGAAGTGTCATCTTTGTATGGAGTCAATAGTACAAGCCAAAGATAGACAGGCTGCTGAAGCAAACAAAAACGC
CAGCATTTTGTTAGAGGAGTTAGACTTGGAAAAGTTAAGGGAAGAAAGTCGGAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGA
GAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGAAGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCTCA
AGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACCTCCAAGTGCCACAACCACTACTACCATAGGTATATCTGC
AACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAACTACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAAAT
TACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATACAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAG
CAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAGCGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGTGA
CAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCCATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAATC
TGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGACCAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCATC
TCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGGGCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAG
GTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAGAGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACTGG
TGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAATCACTATAAGGGGTGGCACTGAATCAACAAGACAAGCAAC
TCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTC
CAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATC
TCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGG
TTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACC
AAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAG
AGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAAC
TTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAG
GCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACAAA
TGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTC
TAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGA
AACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTC
TCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCC
AGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCC
TGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAA
TCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCC
AGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCA
TGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCC
TTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGA
CTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGC
ACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAA
TGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAA
TGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTAT
TGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGTAA
CCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGG
AATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTA
TGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTG
GAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGGTGTGGACTGGACCCTGGGCACCTCACATGAACAG
TGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAA
AAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCT
GTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCT
TCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTA
GCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAA
ATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTTTC

>In-frame_ENST00000282516_ENST00000330838_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3741AA_start in transcript=499_stop in transcript=11724
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHR
DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL
LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA
ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA
DNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREES
RRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTI
TTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQ
PSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIG
RGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSL
MGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQS
TWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTT
VTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSS
SAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNS
ASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPES
MLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHF
SPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSF
EGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAG

--------------------------------------------------------------
>In-frame_ENST00000448238_ENST00000358602_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=15302nt_BP=5028nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAGTGGAGTCTTTC
ATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTTATCAGGTACTGCTGATGGTGCAGACCTCAGG
ACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGGAAAATTGTCCACGGCTGATGGTAAAGCCTTT
GCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGCTGCTGCTGCACTTACCCGTATGAGAGCTGAA
AGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGGAGATGTAAATGCTGTGCGAAAGTTACTCATT
GAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTGTTCTGCTGGATACTATGAGCTTGCACAGGTT
TTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTTAATGGCTGCTGCTAATGGAGGACATGTCAAA
ATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAATACAGCACTTACATATGCTTGTGCTGGAGGC
TATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGAAAATGGTCATACCCCTCTTATGGAAGCTGGA
AGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATACGCATTCTAATGAATTTAAAGAGAGTGCCCTT
ACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGCGGATCAAGAGCATAAAACAGATGAAATGCAC
ACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGACAGCGGTGCCCAAGTGAACATGCCTGCTGAT
TCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTTACTTATTGAAAGAGGAGCTAGCCTGGAAGAG
GTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAATGGTGGCATTACTTCTTGGTCAAGGAGCAAAT
ATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGGCTTTCTGGAAGTGGCAGACTTTCTAATTAAG
GCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGGTCATTTGGAGTTAGTTAAATACTTATTAGCT
GCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTGTGAAAATGGTCATACTGATGTAGCAGATGTC
TTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAATGAAAGCTGCAAGAGCTGGTCATGTTTGTACT
GTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCATACTGTACTGTCCCTGGCTTGTGCAGGGGGT
CATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAAAGATGGCTCAACTATGTTGATAGAAGCAGCA
AAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTCAGCCCCTCCACCAGATGTCACTCAGTTAACT
CCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGTTGTTCCACCTCAGGAGCCTGACAAACCACCT
GCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCTGCTTCTAAACAAAAGTCCAGCAGCCATTTGCCAGCAAACAGCCAGGATGTA
CAGGGTTACATCACCAATCAGTCTCCAGAGAGCATTGTAGAAGAGGCTCAGGGAAAGTTAACAGAACTGGAACAGAGGATAAAAGAAGCC
ATAGAAAAGAATGCACAGCTGCAGTCCTTGGAACTGGCTCATGCTGACCAACTTACCAAGGAGAAGATCGAGGAGCTCAACAAAACAAGG
GAGGAACAAATTCAGAAGAAACAAAAGATTTTGGAGGAACTACAGAAAGTAGAACGAGAGTTACAACTGAAAACTCAGCAGCAGCTAAAA
AAGCAGTATCTAGAGGTTAAAGCTCAAAGAATTCAACTTCAGCAACAGCAGCAACAGTCTTGCCAACACCTGGGATTACTAACTCCTGTT
GGAGTTGGAGAGCAGCTTTCTGAGGGAGACTATGCACGGTTACAGCAAGTGGATCCTGTTTTACTTAAAGATGAACCCCAGCAGACTGCT
GCTCAGATGGGTTTTGCGCCAATCCAGCCTCTGGCGATGCCTCAAGCTTTGCCTCTGGCGGCAGGTCCCTTGCCTCCAGGGTCCATCGCA
AATCTTACAGAACTGCAAGGAGTGATAGTTGGACAGCCAGTACTGGGCCAAGCACAGTTGGCAGGGCTGGGGCAAGGAATTCTGACAGAA
ACACAACAAGGGTTAATGGTAGCCAGCCCTGCTCAGACCCTCAATGACACGCTGGATGACATCATGGCAGCAGTCAGTGGAAGAGCATCT
GCAATGTCAAACACTCCTACCCACAGTATTGCTGCATCCATTTCCCAACCTCAGACTCCAACTCCAAGTCCTATCATCTCTCCTTCAGCC
ATGCTTCCTATCTACCCTGCCATTGATATTGATGCACAGACTGAGAGTAATCATGACACGGCACTAACACTTGCCTGTGCTGGTGGCCAC
GAGGAACTGGTACAAACACTGCTAGAGAGAGGAGCTAGTATAGAGCACCGAGACAAGAAAGGTTTTACTCCACTCATCTTGGCTGCCACA
GCTGGTCATGTTGGTGTTGTGGAAATATTGCTGGACAATGGTGCAGACATTGAAGCCCAGTCTGAAAGAACCAAGGACACACCACTCTCC
TTGGCTTGTTCTGGGGGAAGACAGGAGGTGGTGGAGCTATTGTTAGCTCGAGGGGCAAATAAAGAGCACAGGAATGTTTCTGATTACACA
CCTCTAAGTCTGGCTGCTTCTGGTGGCTATGTGAACATCATCAAAATATTACTAAATGCAGGAGCTGAGATTAACTCTAGAACTGGTAGC
AAATTGGGCATCTCTCCTCTGATGTTAGCAGCTATGAATGGGCATACAGCTGCTGTTAAGCTCCTGTTAGACATGGGCTCTGACATAAAT
GCTCAGATAGAAACCAATCGGAACACTGCCCTTACTTTAGCCTGCTTCCAAGGAAGAACTGAAGTGGTTAGTCTTCTGCTTGATAGAAAA
GCAAATGTTGAACACAGAGCTAAGACTGGTCTCACACCACTAATGGAAGCTGCCTCTGGTGGATATGCGGAGGTGGGCCGAGTTCTTTTG
GATAAAGGTGCTGATGTTAATGCCCCTCCAGTTCCCTCCTCAAGAGATACAGCTTTAACCATAGCAGCAGATAAAGGGCATTACAAATTC
TGTGAGCTTCTTATTGGCAGGGGAGCTCATATTGATGTACGTAACAAGAAGGGGAACACTCCATTGTGGCTAGCAGCAAATGGTGGACAC
CTCGATGTGGTTCAGTTACTGGTGCAAGCAGGTGCAGATGTGGATGCAGCAGATAACCGCAAGATAACTCCTCTTATGGCAGCATTTAGA
AAGGGTCATGTGAAGGTGGTGCGCTACTTAGTCAAAGAAGTCAATCAGTTTCCATCAGATTCTGAATGTATGAGATACATAGCAACCATC
ACTGATAAGGAGATGCTGAAGAAGTGTCATCTTTGTATGGAGTCAATAGTACAAGCCAAAGATAGACAGGCTGCTGAAGCAAACAAAAAC
GCCAGCATTTTGTTAGAGGAGTTAGACTTGGAAAAGTTAAGGGAAGAAAGTCGGAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAA
GAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGAAGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCT
CAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACCTCCAAGTGCCACAACCACTACTACCATAGGTATATCT
GCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAACTACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAA
ATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATACAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGC
AGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAGCGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGT
GACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCCATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAA
TCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGACCAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCA
TCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGGGCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGA
AGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAGAGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACT
GGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAATCACTATAAGGGGTGGCACTGAATCAACAAGACAAGCA
ACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAAT
TCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACA
TCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCT
GGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCA
CCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCC
AGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTA
ACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGA
AGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACA
AATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTT
TCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTA
GAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTT
TCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCT
CCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACC
CCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTC
AATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACAT
CCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCT
CATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGAT
CCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATG
GACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGG
GCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCA
AATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGC
AATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTT
ATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGT
AACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACA
GGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTG
TATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCT
TGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGGTGTGGACTGGACCCTGGGCACCTCACATGAAC
AGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAA
AAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTT
CTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCT
CTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATT
TAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGT
AAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTT
TCCTTCATACATTAAACTATTAATAAGCATAACTTTTCTACTGGTGTAATTTAAGTATAAAGTAAAATAATGGGCATTATCATTGGATGT
TTCCCCACATTGGCTTTTAAAATACCCATCTTGCTTTCTTTTTGGTTTATTTGTAGCAAGGCACATATAGAAGAAGAAATTTCTGGCTTT
TCCATGTTGTTTTATTACCTTTTCTCACTTTTAAAACTAATACAGACTTATCTCCTCACTCCTTTTTCTCTCCTTACCTTTACCACTAAT
ACCAGTAAAATTATCTTTCTGATAGTGAAAAGGTTCTGTCAAGATTTTCACTGTAATGGCTGCTACAGAGATGGACCATCTTCATCATCA
CCAGTGGTTTCTTCTAATTATAAAATGTTTAAACTTTCTGAGAATTTAAAAAGCCACCACTGTTCCCAGTCAGCATATACAAGCTCTTAA
TATTCTGTTTATTAAATAATTCAATGTACTATTTTATATTGGATGATATTGATTCTTAACATTGGCTTTTCAGTCATCAACAGTCAACAT
AAAAATTTCAATTTTCAGTAATTTAGTGGAAAATATCTTATTTCTTTTTTCAATTTTAAAGGCTTCCTGCTTTTTTACCCTTGTATATTA
TCAGTGAAAAGGATCAACAGTTAATTTGAGCCAAGTAATAAAAGAAATTCTGCATTTGTCACGAAGACAATTTATGGTAGACAGATAAAT
ACACAGATTACAGTGTAAAGTCTCCATTTAACCTGTTTATAAAAGATACAAGGCCACACTAAACTACTCAGTGGGATTTATATATTCCAT
CCACTTGAAACAATAAACAGTAATGTATCCAAGAAGATTATGTGTCCTACCCTGTCTCATGGAAAAATTAATTATATGGTTGAAATGTAA
AAGAAAGTAAGCATAAAAATCGAGTAATGTATATATCAATTTGTCTTCTTTTTTTTTAATTAGACATAAAATTTCACACTGGTAAAACAT
AAAAACTAACTAAAATTCATATAAATCACCTAGAGTTGATGATATTAACATGGTTCCTTGGTTGTCAAGTAAATCAAATGATTTCTTCCA
TCTGAGTAAAGAGTAAAGCCTGAGTAAAGAGTAAAAAGATGACTTCTCAAACATATCCAGAAATTTGTAAACAGTACACTCATATCTTTT
AGTTTAAGAAGTGGTCTTAAAATATATAAATTTGTTTTTCCACCTATGTTTAATATGCCCAAATTTAAAGGGAGAGCTAAAAGACAGCCT
ACAAATAAATATAGCTATGAAATAAAATTATAGCACTTTACTAAAAAAGGGATGTAATAATGTTATTTAACGAAGTATTTTATATATGAC
TTGCCACTATTCTATACATAAAATTTTTTTTCTTAATTCTTTCCTGTGTTAACTAGGGTTATTTTCTATTTAAGGTAATCCTGCTGGAGA
ACAGATGCTATCCAATATTTATTACAACACATGAGTTGTGTTGTTTCACAATACTGAATTTCTTAGGTGAGGTATTTTATTTAAAAAGGA
GGGGGAAAACTCCTATATTTTCTTGACTTCAAACCTGTGGGGCCAGGGGATATAGATTGAAATGCTCCGTATTTAGTCTTGGGGATCAGG
CTTGTTTAGTACAATACCATGGTTTTAGAAGTCTGTACTAGGAACATTTTTAAAATACATTTTTTATATTTCAGATGTAATGCAGTGCAC
TTTTATTTGAACAATAAAAAAACCCATAACTTTTTGAGACCATGAAGGTCTTTTATTTTTTAATTTTGAAAATATGTGGTATGTGTATAT
GCAGACTACATCATTGTTTTAAGAAATGATTTAACTCTTGGACATTACACTTGGGTTAGTTCACACCTTAAATCCCCAAGTAGTTAATAT
CTCAATTATTGTATAATCAGTTTATACCATCCATTCCCAACAAAATTCCACATTTCATGCCTTTTCAACATACATTTCAACATAATCAAC
ATATTTACAAACACTGACTTCACTGTTTATAAAGAAGAAATTTCCCCTCCTATTTCCCATTACTGAAAAGTCAAGTCATTTTTATTGATA
CATGAAAATTAATTTTTTTGTAAATGACTACGTATAGTCATTTTTCTCCTTTGGAAAAGGTAAATAGCTTATTAACTAATCCTGTCTTGT
TCTTCACAAAAATAATAGTCCATCCGTGTTTTGACTCAAATAACCTAAATACACATTTTGTAAAAATTTTGTACCCTATATTACTTATTT
TTAAAACAGTACAGTGTTAGACTAAACAGGAAAACTCAAAGTTATAAAATCTCTTCAGATCCTCTAGTTTATTAAATCTATTTTCATGTT

>In-frame_ENST00000448238_ENST00000358602_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3992AA_start in transcript=468_stop in transcript=12446
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQK
KQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFA
PIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTP
THSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV
VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP
LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV
NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV
VRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKK
KEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENV
QIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKA
SIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDI
DKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATA
LTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSP
KPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPM
PTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRP
PLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRP
HSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSD
TSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQ
SVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGN
PMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIK

--------------------------------------------------------------
>In-frame_ENST00000448238_ENST00000509867_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=12992nt_BP=5028nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAGTGGAGTCTTTC
ATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTTATCAGGTACTGCTGATGGTGCAGACCTCAGG
ACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGGAAAATTGTCCACGGCTGATGGTAAAGCCTTT
GCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGCTGCTGCTGCACTTACCCGTATGAGAGCTGAA
AGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGGAGATGTAAATGCTGTGCGAAAGTTACTCATT
GAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTGTTCTGCTGGATACTATGAGCTTGCACAGGTT
TTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTTAATGGCTGCTGCTAATGGAGGACATGTCAAA
ATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAATACAGCACTTACATATGCTTGTGCTGGAGGC
TATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGAAAATGGTCATACCCCTCTTATGGAAGCTGGA
AGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATACGCATTCTAATGAATTTAAAGAGAGTGCCCTT
ACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGCGGATCAAGAGCATAAAACAGATGAAATGCAC
ACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGACAGCGGTGCCCAAGTGAACATGCCTGCTGAT
TCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTTACTTATTGAAAGAGGAGCTAGCCTGGAAGAG
GTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAATGGTGGCATTACTTCTTGGTCAAGGAGCAAAT
ATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGGCTTTCTGGAAGTGGCAGACTTTCTAATTAAG
GCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGGTCATTTGGAGTTAGTTAAATACTTATTAGCT
GCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTGTGAAAATGGTCATACTGATGTAGCAGATGTC
TTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAATGAAAGCTGCAAGAGCTGGTCATGTTTGTACT
GTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCATACTGTACTGTCCCTGGCTTGTGCAGGGGGT
CATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAAAGATGGCTCAACTATGTTGATAGAAGCAGCA
AAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTCAGCCCCTCCACCAGATGTCACTCAGTTAACT
CCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGTTGTTCCACCTCAGGAGCCTGACAAACCACCT
GCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCTGCTTCTAAACAAAAGTCCAGCAGCCATTTGCCAGCAAACAGCCAGGATGTA
CAGGGTTACATCACCAATCAGTCTCCAGAGAGCATTGTAGAAGAGGCTCAGGGAAAGTTAACAGAACTGGAACAGAGGATAAAAGAAGCC
ATAGAAAAGAATGCACAGCTGCAGTCCTTGGAACTGGCTCATGCTGACCAACTTACCAAGGAGAAGATCGAGGAGCTCAACAAAACAAGG
GAGGAACAAATTCAGAAGAAACAAAAGATTTTGGAGGAACTACAGAAAGTAGAACGAGAGTTACAACTGAAAACTCAGCAGCAGCTAAAA
AAGCAGTATCTAGAGGTTAAAGCTCAAAGAATTCAACTTCAGCAACAGCAGCAACAGTCTTGCCAACACCTGGGATTACTAACTCCTGTT
GGAGTTGGAGAGCAGCTTTCTGAGGGAGACTATGCACGGTTACAGCAAGTGGATCCTGTTTTACTTAAAGATGAACCCCAGCAGACTGCT
GCTCAGATGGGTTTTGCGCCAATCCAGCCTCTGGCGATGCCTCAAGCTTTGCCTCTGGCGGCAGGTCCCTTGCCTCCAGGGTCCATCGCA
AATCTTACAGAACTGCAAGGAGTGATAGTTGGACAGCCAGTACTGGGCCAAGCACAGTTGGCAGGGCTGGGGCAAGGAATTCTGACAGAA
ACACAACAAGGGTTAATGGTAGCCAGCCCTGCTCAGACCCTCAATGACACGCTGGATGACATCATGGCAGCAGTCAGTGGAAGAGCATCT
GCAATGTCAAACACTCCTACCCACAGTATTGCTGCATCCATTTCCCAACCTCAGACTCCAACTCCAAGTCCTATCATCTCTCCTTCAGCC
ATGCTTCCTATCTACCCTGCCATTGATATTGATGCACAGACTGAGAGTAATCATGACACGGCACTAACACTTGCCTGTGCTGGTGGCCAC
GAGGAACTGGTACAAACACTGCTAGAGAGAGGAGCTAGTATAGAGCACCGAGACAAGAAAGGTTTTACTCCACTCATCTTGGCTGCCACA
GCTGGTCATGTTGGTGTTGTGGAAATATTGCTGGACAATGGTGCAGACATTGAAGCCCAGTCTGAAAGAACCAAGGACACACCACTCTCC
TTGGCTTGTTCTGGGGGAAGACAGGAGGTGGTGGAGCTATTGTTAGCTCGAGGGGCAAATAAAGAGCACAGGAATGTTTCTGATTACACA
CCTCTAAGTCTGGCTGCTTCTGGTGGCTATGTGAACATCATCAAAATATTACTAAATGCAGGAGCTGAGATTAACTCTAGAACTGGTAGC
AAATTGGGCATCTCTCCTCTGATGTTAGCAGCTATGAATGGGCATACAGCTGCTGTTAAGCTCCTGTTAGACATGGGCTCTGACATAAAT
GCTCAGATAGAAACCAATCGGAACACTGCCCTTACTTTAGCCTGCTTCCAAGGAAGAACTGAAGTGGTTAGTCTTCTGCTTGATAGAAAA
GCAAATGTTGAACACAGAGCTAAGACTGGTCTCACACCACTAATGGAAGCTGCCTCTGGTGGATATGCGGAGGTGGGCCGAGTTCTTTTG
GATAAAGGTGCTGATGTTAATGCCCCTCCAGTTCCCTCCTCAAGAGATACAGCTTTAACCATAGCAGCAGATAAAGGGCATTACAAATTC
TGTGAGCTTCTTATTGGCAGGGGAGCTCATATTGATGTACGTAACAAGAAGGGGAACACTCCATTGTGGCTAGCAGCAAATGGTGGACAC
CTCGATGTGGTTCAGTTACTGGTGCAAGCAGGTGCAGATGTGGATGCAGCAGATAACCGCAAGATAACTCCTCTTATGGCAGCATTTAGA
AAGGGTCATGTGAAGGTGGTGCGCTACTTAGTCAAAGAAGTCAATCAGTTTCCATCAGATTCTGAATGTATGAGATACATAGCAACCATC
ACTGATAAGGAGATGCTGAAGAAGTGTCATCTTTGTATGGAGTCAATAGTACAAGCCAAAGATAGACAGGCTGCTGAAGCAAACAAAAAC
GCCAGCATTTTGTTAGAGGAGTTAGACTTGGAAAAGTTAAGGGAAGAAAGTCGGAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAA
GAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGAAGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCT
CAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACCTCCAAGTGCCACAACCACTACTACCATAGGTATATCT
GCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAACTACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAA
ATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATACAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGC
AGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAGCGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGT
GACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCCATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAA
TCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGACCAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCA
TCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGGGCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGA
AGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAGAGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACT
GGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAATCACTATAAGGGGTGGCACTGAATCAACAAGACAAGCA
ACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAAT
TCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACA
TCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCT
GGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCA
CCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCC
AGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTA
ACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGA
AGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACA
AATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTT
TCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTA
GAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTT
TCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCT
CCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACC
CCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTC
AATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACAT
CCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCT
CATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGAT
CCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATG
GACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGG
GCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCA
AATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGC
AATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTT
ATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGT
AACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACA
GGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTG
TATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCT
TGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGGTGTGGACTGGACCCTGGGCACCTCACATGAAC
AGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAA
AAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTT
CTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCT
CTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATT
TAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGT
AAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTT

>In-frame_ENST00000448238_ENST00000509867_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3992AA_start in transcript=468_stop in transcript=12446
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQK
KQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFA
PIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTP
THSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV
VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP
LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV
NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV
VRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKK
KEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENV
QIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKA
SIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDI
DKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATA
LTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSP
KPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPM
PTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRP
PLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRP
HSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSD
TSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQ
SVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGN
PMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIK

--------------------------------------------------------------
>In-frame_ENST00000448238_ENST00000330838_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(transcript)=12239nt_BP=5028nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAGTGGAGTCTTTC
ATTTTGGATCAGGATGATTTGGAAAATCCAATGCTGGAAACAGCTTCCAAGTTGCTCTTATCAGGTACTGCTGATGGTGCAGACCTCAGG
ACAGTAGATCCAGAAACACAGGCTAGACTGGAAGCTTTACTAGAAGCTGCAGGAATAGGAAAATTGTCCACGGCTGATGGTAAAGCCTTT
GCAGATCCTGAAGTACTTCGGAGGTTGACATCGTCTGTTAGTTGTGCGTTGGATGAAGCTGCTGCTGCACTTACCCGTATGAGAGCTGAA
AGCACAGCAAATGCAGGGCAGTCGGACAACCGCAGTTTGGCAGAAGCCTGTTCAGAAGGAGATGTAAATGCTGTGCGAAAGTTACTCATT
GAAGGGCGAAGTGTAAATGAACACACAGAGGAAGGGGAGAGCCTCCTTTGTTTAGCTTGTTCTGCTGGATACTATGAGCTTGCACAGGTT
TTGTTGGCAATGCATGCAAATGTGGAAGATAGGGGAATCAAAGGTGACATTACACCTTTAATGGCTGCTGCTAATGGAGGACATGTCAAA
ATTGTGAAGTTGCTGCTAGCTCATAAAGCAGATGTTAATGCACAGTCTTCAACAGGCAATACAGCACTTACATATGCTTGTGCTGGAGGC
TATGTAGATGTTGTAAAGGTGCTCTTGGAATCCGGTGCTAGTATTGAGGACCATAATGAAAATGGTCATACCCCTCTTATGGAAGCTGGA
AGTGCTGGACATGTGGAAGTAGCCAGATTGCTGCTAGAAAATGGGGCTGGCATTAATACGCATTCTAATGAATTTAAAGAGAGTGCCCTT
ACCTTAGCTTGTTACAAAGGACACTTAGAGATGGTGCGATTTCTTTTGGAAGCAGGCGCGGATCAAGAGCATAAAACAGATGAAATGCAC
ACTGCTCTGATGGAGGCTTGCATGGATGGCCATGTTGAAGTAGCTAGGTTACTTCTTGACAGCGGTGCCCAAGTGAACATGCCTGCTGAT
TCATTTGAGTCACCATTAACTTTGGCTGCATGTGGTGGGCATGTGGAACTTGCGGCTTTACTTATTGAAAGAGGAGCTAGCCTGGAAGAG
GTCAATGATGAAGGTTATACACCATTGATGGAAGCAGCTCGAGAAGGACATGAAGAAATGGTGGCATTACTTCTTGGTCAAGGAGCAAAT
ATCAATGCACAGACAGAAGAAACTCAAGAAACTGCCTTGACTCTGGCTTGCTGTGGAGGCTTTCTGGAAGTGGCAGACTTTCTAATTAAG
GCAGGAGCCGATATAGAACTAGGGTGTTCTACCCCTTTAATGGAAGCTGCTCAAGAGGGTCATTTGGAGTTAGTTAAATACTTATTAGCT
GCAGGAGCTAACGTTCATGCAACAACAGCAACAGGGGATACAGCACTAACATATGCCTGTGAAAATGGTCATACTGATGTAGCAGATGTC
TTACTTCAGGCAGGCGCAGATCTGGAACATGAATCTGAAGGTGGAAGAACTCCTTTAATGAAAGCTGCAAGAGCTGGTCATGTTTGTACT
GTTCAGTTCTTAATTAGTAAAGGAGCGAATGTGAATAGAACCACAGCTAATAATGACCATACTGTACTGTCCCTGGCTTGTGCAGGGGGT
CATCTGGCAGTGGTGGAACTACTTTTGGCTCATGGGGCAGATCCTACTCACCGTTTGAAAGATGGCTCAACTATGTTGATAGAAGCAGCA
AAAGGTGGCCATACAAGTGTTGTTTGCTATCTCTTGGATTATCCTAATAACTTGCTTTCAGCCCCTCCACCAGATGTCACTCAGTTAACT
CCCCCATCCCACGATTTAAATAGGGCTCCTCGTGTACCAGTTCAAGCACTGCCCATGGTTGTTCCACCTCAGGAGCCTGACAAACCACCT
GCCAATGTTGCCACCACTCTTCCCATCAGGAATAAAGCAGTCAGTGGAAGAGCATCTGCAATGTCAAACACTCCTACCCACAGTATTGCT
GCATCCATTTCCCAACCTCAGACTCCAACTCCAAGTCCTATCATCTCTCCTTCAGCCATGCTTCCTATCTACCCTGCCATTGATATTGAT
GCACAGACTGAGAGTAATCATGACACGGCACTAACACTTGCCTGTGCTGGTGGCCACGAGGAACTGGTACAAACACTGCTAGAGAGAGGA
GCTAGTATAGAGCACCGAGACAAGAAAGGTTTTACTCCACTCATCTTGGCTGCCACAGCTGGTCATGTTGGTGTTGTGGAAATATTGCTG
GACAATGGTGCAGACATTGAAGCCCAGTCTGAAAGAACCAAGGACACACCACTCTCCTTGGCTTGTTCTGGGGGAAGACAGGAGGTGGTG
GAGCTATTGTTAGCTCGAGGGGCAAATAAAGAGCACAGGAATGTTTCTGATTACACACCTCTAAGTCTGGCTGCTTCTGGTGGCTATGTG
AACATCATCAAAATATTACTAAATGCAGGAGCTGAGATTAACTCTAGAACTGGTAGCAAATTGGGCATCTCTCCTCTGATGTTAGCAGCT
ATGAATGGGCATACAGCTGCTGTTAAGCTCCTGTTAGACATGGGCTCTGACATAAATGCTCAGATAGAAACCAATCGGAACACTGCCCTT
ACTTTAGCCTGCTTCCAAGGAAGAACTGAAGTGGTTAGTCTTCTGCTTGATAGAAAAGCAAATGTTGAACACAGAGCTAAGACTGGTCTC
ACACCACTAATGGAAGCTGCCTCTGGTGGATATGCGGAGGTGGGCCGAGTTCTTTTGGATAAAGGTGCTGATGTTAATGCCCCTCCAGTT
CCCTCCTCAAGAGATACAGCTTTAACCATAGCAGCAGATAAAGGGCATTACAAATTCTGTGAGCTTCTTATTGGCAGGGGAGCTCATATT
GATGTACGTAACAAGAAGGGGAACACTCCATTGTGGCTAGCAGCAAATGGTGGACACCTCGATGTGGTTCAGTTACTGGTGCAAGCAGGT
GCAGATGTGGATGCAGCAGATAACCGCAAGATAACTCCTCTTATGGCAGCATTTAGAAAGGGTCATGTGAAGGTGGTGCGCTACTTAGTC
AAAGAAGTCAATCAGTTTCCATCAGATTCTGAATGTATGAGATACATAGCAACCATCACTGATAAGGAGATGCTGAAGAAGTGTCATCTT
TGTATGGAGTCAATAGTACAAGCCAAAGATAGACAGGCTGCTGAAGCAAACAAAAACGCCAGCATTTTGTTAGAGGAGTTAGACTTGGAA
AAGTTAAGGGAAGAAAGTCGGAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGA
AGGAAACTAGAAGAAATTGAAGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAG
CCTGAAGTCTTGACAGAACCTCCAAGTGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGT
AAAAGAAATAATACCATAACTACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGAT
GATCCACTACCAATTTCATACAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAAC
ATGAGGATTTCCAGCTGCAGCGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACT
GTGAGCAGCAAAAAGCAGCCATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCA
GAAACTATCAGTGAAGGGACCAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACA
GTAGCAAGTCCTAAGCGTGGGCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTG
ATATCCAGAGTGATTGGAAGAGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGAC
AAGACTGGAGACCGGATAATCACTATAAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCA
GACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACT
GCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCA
ATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCT
CCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACT
TTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTG
CCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCA
GCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCC
AATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAA
CACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCA
TCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGC
AGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCT
CAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACT
TACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACT
GCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCT
TCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGT
GCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCT
CAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCA
GGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCA
ACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAAC
TTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGA
GTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCT
ATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACAT
AGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGA
CCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAG
CATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCT
ATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCC
ACGGAAAATAATGGCCCTCAAACGGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGA
TCAGCTTGTTAGCCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGAT
GTGCTTGACTGAAGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCA
TCATCCGTTTTACCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCT
GTTCTTTGGCTGGTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTT
TAGAATGGCAAATAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTT

>In-frame_ENST00000448238_ENST00000330838_TCGA-A2-A0T1-01A_NIPBL_chr5_37010327_+_ANKRD17_chr4_74043250_length(amino acids)=3741AA_start in transcript=468_stop in transcript=11693
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKVESFILDQDD
LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAG
QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL
AHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK
GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY
TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH
ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE
LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT
LPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHR
DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL
LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA
ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA
DNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREES
RRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTI
TTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQ
PSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIG
RGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSL
MGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQS
TWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTT
VTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSS
SAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNS
ASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPES
MLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHF
SPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSF
EGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NIPBL-ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIPBL-ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIPBL-ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNIPBLC4551851Cornelia de Lange Syndrome 116CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNIPBLC0270972Cornelia De Lange Syndrome8CLINGEN;CTD_human
HgeneNIPBLC1802395Congenital muscular hypertrophy-cerebral syndrome3CTD_human
HgeneNIPBLC1853099Cornelia de Lange Syndrome 33CTD_human
HgeneNIPBLC0005941Bone Diseases, Developmental1CTD_human
HgeneNIPBLC0018798Congenital Heart Defects1CTD_human
HgeneNIPBLC0155536Paracousis1CTD_human
HgeneNIPBLC0260662Hearing problem1CTD_human
HgeneNIPBLC0376634Craniofacial Abnormalities1CTD_human
HgeneNIPBLC0877848Distorted hearing1CTD_human
HgeneNIPBLC1510450Dysacusis1CTD_human
HgeneNIPBLC2750805Chromosome 5p13 Duplication Syndrome1ORPHANET