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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NKTR-HAUS2 (FusionGDB2 ID:58924)

Fusion Gene Summary for NKTR-HAUS2

check button Fusion gene summary
Fusion gene informationFusion gene name: NKTR-HAUS2
Fusion gene ID: 58924
HgeneTgene
Gene symbol

NKTR

HAUS2

Gene ID

4820

55142

Gene namenatural killer cell triggering receptorHAUS augmin like complex subunit 2
Synonymsp104C15orf25|CEP27|HsT17025
Cytomap

3p22.1

15q15.2

Type of geneprotein-codingprotein-coding
DescriptionNK-tumor recognition proteinNK-TR proteinPPIasenatural killer triggering receptornatural killer-tumor recognition sequencenatural-killer cells cyclophilin-related proteinpeptidyl-prolyl cis-trans isomerase NKTRrotamaseHAUS augmin-like complex subunit 2centrosomal protein 27kDacentrosomal protein of 27 kDa
Modification date2020031320200313
UniProtAcc.

Q9NVX0

Ensembl transtripts involved in fusion geneENST00000232978, ENST00000460910, 
ENST00000442970, 		ENST00000260372, 
ENST00000568876, ENST00000568846, 
Fusion gene scores* DoF score8 X 6 X 6=2882 X 2 X 2=8
# samples 102
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NKTR [Title/Abstract] AND HAUS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNKTR(42674315)-HAUS2(42858805), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNKTR

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check buttonFusion gene breakpoints across NKTR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HAUS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01ANKTRchr3

42674315

+HAUS2chr15

42858805

+


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Fusion Gene ORF analysis for NKTR-HAUS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000232978ENST00000260372NKTRchr3

42674315

+HAUS2chr15

42858805

+
In-frameENST00000232978ENST00000568876NKTRchr3

42674315

+HAUS2chr15

42858805

+
5CDS-intronENST00000232978ENST00000568846NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-3CDSENST00000460910ENST00000260372NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-3CDSENST00000460910ENST00000568876NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-intronENST00000460910ENST00000568846NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-3CDSENST00000442970ENST00000260372NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-3CDSENST00000442970ENST00000568876NKTRchr3

42674315

+HAUS2chr15

42858805

+
intron-intronENST00000442970ENST00000568846NKTRchr3

42674315

+HAUS2chr15

42858805

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000232978NKTRchr342674315+ENST00000260372HAUS2chr1542858805+434996147973308
ENST00000232978NKTRchr342674315+ENST00000568876HAUS2chr1542858805+221396147973308

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000232978ENST00000260372NKTRchr342674315+HAUS2chr1542858805+0.0006524590.9993475
ENST00000232978ENST00000568876NKTRchr342674315+HAUS2chr1542858805+0.0008738360.99912614

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Fusion Genomic Features for NKTR-HAUS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NKTRchr342674315+HAUS2chr1542858804+1.31E-060.9999987
NKTRchr342674315+HAUS2chr1542858804+1.31E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NKTR-HAUS2


check button Go to

FGviewer for the breakpoints of chr3:42674315-chr15:42858805

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HAUS2

Q9NVX0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917194_244257.66666666666671463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917219_240257.66666666666671463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+91710_175257.66666666666671463.0DomainPPIase cyclophilin-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917421_457257.66666666666671463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917466_574257.66666666666671463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917664_814257.66666666666671463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+917970_1010257.66666666666671463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42674315chr15:42858805ENST00000232978+9171311_1348257.66666666666671463.0RegionNote=Arg/Ser tandem repeat-rich
TgeneHAUS2chr3:42674315chr15:42858805ENST000002603724651_115166.0236.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS2chr3:42674315chr15:42858805ENST000005688763551_115135.0205.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for NKTR-HAUS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000232978_ENST00000260372_TCGA-HU-A4GH-01A_NKTR_chr3_42674315_+_HAUS2_chr15_42858805_length(transcript)=4349nt_BP=961nt
GTACTCTCGCGGTATTTGTCCCGACTCTCGCGGGGTTTAGCGTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCG
GCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCT
CGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGAGCCGGTTGGTCGCATTATGTTTCAGCTCT
TCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAAACAACTGGGAAGAAGTTAT
GTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAGGTGGAGAAT
CAATTTATGGTGGATATTTTAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTTTATCAATGGCAAATCGAGGGAAACATA
CCAATGGTTCCCAGTTTTTCATTACCACAAAGCCTGCTCCACACCTGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTG
AAGTAATCGAACAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGCAGATGTGCGAGTTATTGACTGTGGAGTACTTGCCA
CAAAATCAATAAAAGATGTTTTTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGATTCCTCTTCCAATTCCTCCTCTTCTT
CAGAATCATCTTCAGAAAGTGAACTTGAACATGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTAAACGTTCTAAAAAGA
GGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAACATGCAATGAACCCAAAAGGAACCAGGCTTTAGCAAAGATGGATATATT
GGTGACTGAGACAGAAGAACTGGCAGAGAATATACTCAAGTGGCGTAAACAACAAAACGAAGTTTCGTCTTGTATCCCCAAAATATTAGC
TGAAGAAAGTTATCTTTATAAACATGATATTATAATGCCTCCTTTACCTTTTACTTCTAAAGTTCATGTCCAAACTATTAATGCCAAGTA
GTCATCAACTTTATTTTTGCTTAATTATGTGTAGTCATATGAAGTCTATTTCTAGTTGACTGTAACATGGGTATTAATAGTCTTTGCTGC
TGGTAATACTGAAAGAACCTGCTTTATATTGGAGTATCAAGATCTCAGGTTCATTAAGACCAAACTGACTTTTCCTTTGTTTTTCATATA
TTTTTATTCTACCTTTCAGTAAAACTAGAGAAGCTAAAAAATAGCCATGACAATTTATTAATATAAGTGAATTAACCATTTCTCAGGTGG
GAAATTCTCTTTTTTTAAAAATGTGTGTTTATCGTCTGGTGTGGTGGCTCACACCTGTAATCCTAACACTTGGGGAGGCTGAGGCGGGCA
GATCACTTAAACCCAGGAGTTCAAGACCAGCCTGGGTAACATGGTGAAATCCCATATCTACAAAATAAACAAAAAATTAGCCGACCATGG
TGGTGCATGCCTGTAGTCCCAGCTATTCGGGAGGCTGAGGTAAGAGGATCACCTAAGCCTGTGAGGTCATGGTTGCAATGAGTCATGATC
ACGCCACTGCGCTACAGCCTGGGCGACACAGTAAGACCCTGTCTCAAAAAAAAGAAGTGTGTTTCTGGCCAGGCACGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCCTAGGTGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACACCTGTCT
CTACTAAAAATACAAAAATTAGGCCGGGCGCAGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGACCCAGATGGGTGGATCACC
TGAGGTCAGGAGTTTGAGACCAGCCTTGACAACATGGTGAAACCCCATCTCTGGTAGAAATATAAAAAATTAACCGGGCATGGTGGTGGA
CGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAGATCGTGCCTC
TGCACTCCAACCTGGGTGATGGAGCAAGACTCCATCTCCAAAAAAATAAAAAATACAAAAATTAGCCAGGCATGGTAGCATGTGCCTGTA
ATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCCAGATCGTGCCACCGCACTCT
AGCCTGGGCAACAGAGCAAGACTCTGTCTTAAAAAAAAAAAAAAAAGGTGTTTCTGAATTAGAAGGGTCTTCTTGAATCTGAAAATGTCT
ATGATGATTATTCCTGTGGGAATGTCACTAAGTATGCAGAAAAGAGTAACACAGCCAGCCTGACTTATCCTTTGAAAGGCCTGATTATAA
GGTTTGTCCTCAGCTGTTGCATCTGGGAACTTAGATATCAGAAGGTATCTTAGTCTGTTCTGCTGTCATAACAGAATTACACAAACTAAG
TATTTTATAATGAACAGAAGTTTATTTGGTTGACAGGTGTGGAGGCTAGGCAGTCCAAGAACATGGTGCCAGCATCTAGTGAGGGTCTTG
CCATGGCAGAAGGCACCACATGGCAAGTGAGCATGAGAAAGATATATGGGTCTAAACTTAGCCTTTTATCATGAGCCCACTCCCAAGATA
GCAGCACTAATTCATTAATGAGGGCAAAGCCCTCCTTACCTAATTACTTTTTAAAGGTCTCATAACACTTTTACAATGTCAATTAAATTT
CCAACACTTGAACTTTGGGGGACATATTTAAACCTTAACAGGAGGGCTCCACTCACTGAAAAGAGTCGTTCATGGTAGCTAACCTGTGGT
TTGTGCTGAAAACCTGCTTTCTTCCTGGGAGTCTAGAATTTTGGTACATGGTAGGTAGAAGGTACCTACGTGACCAGCCCCCAGTAAAAA
CCCTGGGCACTGTATCTCTAACAAGTTTCCCTGGTAAACAACATTTCTCACATGTTGTCACAATTCAGTTGCTGGTGGAATGAAACAACA
GATATGTGTGACTCCACTGTTAGAGGACTCTGGAAGCTTATACCTGGTTTCCCCCAGACTTTGCCTCTGTACCTTTTCTCTTTGCTGTTT
TGCTTCATATGCTTTTGCTGTAATAAATCATAGCTGTGTGATGATATGCTGAGTCTTGTGAATTCTCCTAGCAAATCATGGAACCTGGAG
GTAGTCTTGGAGACCCTGGCATACAAAGCAGTTCCTAAGTGTTTACTGGTAGCTGTAGGAATAGGCAAAGAAGAAACAGCAAAGAAAAAG
GCACACTGTGGTATAACTTTGGAGGTTTACCTTGCAAAATGCTCAGATATTTTACCTATCAGAGGTTATTGTGCATATAATAGAGAGTGA
TATACTAACAACTGCCTCAGGATATACTCTTTTTAATCAGTATTGTAACTAACCTTGGCTTATTTTACTTTTAGACTTGGGGTTCTATTT
TGCTTTAAAACATGTACATCAGTTTTGTTTTTTGTTTTGTTCTTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAAGACAGGATCTCACTCT
GTCACCCAGGTTGCTGAGAGTGTGGTGTGGCCCAATCTTGACCTCACTGCAGCCTTGACCTCTCAGGCTCAAGTGATCCTCCCACCTCAG
CCTCCCAAGTAGCTGGGACTATAGGCACGCGCCACCACGCCTGGCTAATTTTTGTATTTTCTGTAGAGACAGAGTTTTGCCATGTTGTTG
AGGCTGGTCTTGAACTCCTGGGTTCAAACGACCCTCCCGCCTCAGCCTCCGAAAGTGCTGGGAGTACAGGTGTTAGCCACTGCGCCTGGC
CTCATTGTACTCCTTAACACAAGAAGACTTCAACAATGATAAGTAGTTGTTTATAAGGAAGCAGGATCATTACCAAAATAAATCCTGCTA
AAACAACAGGAATCATGTTTTAAAGCCTAGTTTGCTAATTTTTGCTAGTAGGATAAGAGTGATCGTAATATCTCGAACATTACATAGACA
CTTAAAACCTTTAGTTGTATTTCATCAAAAATCTGTTCATACCCCACGTTGGTTTCAAAACATACTATGCTTTTTCTTCGTGTTATTTCC
TATATTCATTTTTGTGTGTATGTGTATGTCACAAATATTGATATGCCTGGTTGTTTATTTTTGTTTTCTATTATGCCTTTTTCAAAATAT

>In-frame_ENST00000232978_ENST00000260372_TCGA-HU-A4GH-01A_NKTR_chr3_42674315_+_HAUS2_chr15_42858805_length(amino acids)=308AA_start in transcript=47_stop in transcript=973
MGGPAWGRRRRSVSGVGVWLQWQCFLFCSRGPAQAGGQPALAATSVAMGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLC
SGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHL
DGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRR

--------------------------------------------------------------
>In-frame_ENST00000232978_ENST00000568876_TCGA-HU-A4GH-01A_NKTR_chr3_42674315_+_HAUS2_chr15_42858805_length(transcript)=2213nt_BP=961nt
GTACTCTCGCGGTATTTGTCCCGACTCTCGCGGGGTTTAGCGTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCG
GCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCT
CGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGAGCCGGTTGGTCGCATTATGTTTCAGCTCT
TCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAAACAACTGGGAAGAAGTTAT
GTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAGGTGGAGAAT
CAATTTATGGTGGATATTTTAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTTTATCAATGGCAAATCGAGGGAAACATA
CCAATGGTTCCCAGTTTTTCATTACCACAAAGCCTGCTCCACACCTGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTG
AAGTAATCGAACAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGCAGATGTGCGAGTTATTGACTGTGGAGTACTTGCCA
CAAAATCAATAAAAGATGTTTTTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGATTCCTCTTCCAATTCCTCCTCTTCTT
CAGAATCATCTTCAGAAAGTGAACTTGAACATGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTAAACGTTCTAAAAAGA
GGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAACATGCAATGAACCCAAAAGGAACCAGGCTTTAGCAAAGATGGATATATT
GGTGACTGAGACAGAAGAACTGGCAGAGAATATACTCAAGTGGCGTAAACAACAAAACGAAGTTTCGTCTTGTATCCCCAAAATATTAGC
TGAAGAAAGTTATCTTTATAAACATGATATTATAATGCCTCCTTTACCTTTTACTTCTAAAGTTCATGTCCAAACTATTAATGCCAAGTA
GTCATCAACTTTATTTTTGCTTAATTATGTGTAGTCATATGAAGTCTATTTCTAGTTGACTGTAACATGGGTATTAATAGTCTTTGCTGC
TGGTAATACTGAAAGAACCTGCTTTATATTGGAGTATCAAGATCTCAGGTTCATTAAGACCAAACTGACTTTTCCTTTGTTTTTCATATA
TTTTTATTCTACCTTTCAGTAAAACTAGAGAAGCTAAAAAATAGCCATGACAATTTATTAATATAAGTGAATTAACCATTTCTCAGGTGG
GAAATTCTCTTTTTTTAAAAATGTGTGTTTATCGTCTGGTGTGGTGGCTCACACCTGTAATCCTAACACTTGGGGAGGCTGAGGCGGGCA
GATCACTTAAACCCAGGAGTTCAAGACCAGCCTGGGTAACATGGTGAAATCCCATATCTACAAAATAAACAAAAAATTAGCCGACCATGG
TGGTGCATGCCTGTAGTCCCAGCTATTCGGGAGGCTGAGGTAAGAGGATCACCTAAGCCTGTGAGGTCATGGTTGCAATGAGTCATGATC
ACGCCACTGCGCTACAGCCTGGGCGACACAGTAAGACCCTGTCTCAAAAAAAAGAAGTGTGTTTCTGGCCAGGCACGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCCTAGGTGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACACCTGTCT
CTACTAAAAATACAAAAATTAGGCCGGGCGCAGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGACCCAGATGGGTGGATCACC
TGAGGTCAGGAGTTTGAGACCAGCCTTGACAACATGGTGAAACCCCATCTCTGGTAGAAATATAAAAAATTAACCGGGCATGGTGGTGGA
CGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAGATCGTGCCTC

>In-frame_ENST00000232978_ENST00000568876_TCGA-HU-A4GH-01A_NKTR_chr3_42674315_+_HAUS2_chr15_42858805_length(amino acids)=308AA_start in transcript=47_stop in transcript=973
MGGPAWGRRRRSVSGVGVWLQWQCFLFCSRGPAQAGGQPALAATSVAMGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLC
SGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHL
DGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NKTR-HAUS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NKTR-HAUS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NKTR-HAUS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource