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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NLK-ELMO1 (FusionGDB2 ID:58987)

Fusion Gene Summary for NLK-ELMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: NLK-ELMO1
Fusion gene ID: 58987
HgeneTgene
Gene symbol

NLK

ELMO1

Gene ID

51701

9844

Gene namenemo like kinaseengulfment and cell motility 1
Synonyms-CED-12|CED12|ELMO-1
Cytomap

17q11.2

7p14.2-p14.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase NLKengulfment and cell motility protein 1ced-12 homolog 1
Modification date2020031320200313
UniProtAcc

Q9UBE8

Q92556

Ensembl transtripts involved in fusion geneENST00000407008, ENST00000583517, 
ENST00000582037, 		ENST00000341056, 
ENST00000396045, ENST00000310758, 
ENST00000396040, ENST00000442504, 
ENST00000448602, ENST00000479447, 
Fusion gene scores* DoF score18 X 10 X 9=162017 X 13 X 9=1989
# samples 2018
** MAII scorelog2(20/1620*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1989*10)=-3.46597446450407
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLK [Title/Abstract] AND ELMO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNLK(26449758)-ELMO1(37172839), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLK

GO:0050821

protein stabilization

25512613


check buttonFusion gene breakpoints across NLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ELMO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-A70Z-01ANLKchr17

26449758

+ELMO1chr7

37172839

-
ChimerDB4LGGTCGA-FG-A70Z-01ANLKchr17

26449758

-ELMO1chr7

37172839

-


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Fusion Gene ORF analysis for NLK-ELMO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000407008ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-3CDSENST00000583517ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-3CDSENST00000582037ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407008NLKchr1726449758+ENST00000341056ELMO1chr737172839-359913067182403561

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407008ENST00000341056NLKchr1726449758+ELMO1chr737172839-0.007082790.9929172

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Fusion Genomic Features for NLK-ELMO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NLK-ELMO1


check button Go to

FGviewer for the breakpoints of chr17:26449758-chr7:37172839

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLK

Q9UBE8

ELMO1

Q92556

FUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). {ECO:0000250|UniProtKB:O54949, ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582, ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709, ECO:0000269|PubMed:20061393, ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}.FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211106_111196.0528.0Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211115_119196.0528.0Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21122_25196.0528.0Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21127_34196.0528.0Compositional biasNote=Poly-His
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21142_48196.0528.0Compositional biasNote=Poly-His
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21171_83196.0528.0Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211144_152196.0528.0Nucleotide bindingATP
TgeneELMO1chr17:26449758chr7:37172839ENST000003107581222555_676362.0728.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056010319_49264.0430.0DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056010555_67664.0430.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604007319_4920248.0DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604007555_6760248.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604507319_4920248.0DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604507555_6760248.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST000004425041222555_676362.0728.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST000004486021222555_676362.0728.0DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST000003107581222707_714362.0728.0MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056010707_71464.0430.0MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604007707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST0000039604507707_7140248.0MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST000004425041222707_714362.0728.0MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST000004486021222707_714362.0728.0MotifNote=SH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211138_427196.0528.0DomainProtein kinase
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211298_300196.0528.0MotifNote=TQE
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211428_527196.0528.0RegionRequired for homodimerization and kinase activation and localization to the nucleus
TgeneELMO1chr17:26449758chr7:37172839ENST000003107581222319_492362.0728.0DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST000004425041222319_492362.0728.0DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST000004486021222319_492362.0728.0DomainELMO


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Fusion Gene Sequence for NLK-ELMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000407008_ENST00000341056_TCGA-FG-A70Z-01A_NLK_chr17_26449758_+_ELMO1_chr7_37172839_length(transcript)=3599nt_BP=1306nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATAATCATGTCAACCCTGCCATGGACTTCACGCAGACTCCACCTGG
GATGTTGGCTCTGGACAACATGCTGTACTTTGCCAAGCACCACCAAGATGCCTACATCCGGATTGTGCTTGAGAACAGTAGTCGAGAAGA
CAAGCATGAATGTCCCTTTGGCCGCAGTAGTATAGAGCTGACCAAGATGCTATGTGAGATCTTGAAAGTGGGCGAGTTGCCTAGTGAGAC
CTGCAACGACTTCCACCCGATGTTCTTCACCCACGACAGATCCTTTGAGGAGTTTTTCTGCATCTGTATCCAGCTCCTGAACAAGACATG
GAAGGAAATGAGGGCAACTTCTGAAGACTTCAACAAGGTAATGCAGGTGGTGAAGGAGCAGGTTATGAGAGCACTTACAACCAAGCCTAG
CTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCAGTCCGAGAGGATGAACCAGGAAGA
TTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGATCAAACAGCAACGCCTGAACCGCCTTGT
GGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCTTTCGCCAAATCACAAAGTCCTGCA
TTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAACTGCCGGTGGCAGATATCAAAGCCGTGGT
GACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGAACTCGCTTTCTCCATCTTGTATGA
CTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATGGACTGAATGCGCTACTCGGGAAGGACAT
GATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCTGGACCTGGAAAACATCCAGATCCC
TGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACTGAAGTGGCCGGGCCCAGACATGCCCCTT
CCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACCGTCCTTTGGTAAAGGGAAGCTGTGGGTC
CACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCTCACCGCCCTGATTCTGTTCCTCGGCTCC
ACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGCCAGTAAGAAGGCCAAAGGGCCCTTCCAT
CCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTGCCCAAAAACTTGCCCACCAGACCAAGGG
CAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCCCACATCCTCCTTTCCCCTCTCTCTAGAA
TCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTCTCCCTGCTTTTGCCTTGCTCTGTTCCTC
TTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAACAGTCCACAGGTCCCATGCCCACTTTGC
GTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCCTGCCCCAGGCCAGAACTGCCTTCTTCAT
TTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTCCATCTCTAATAGACTAAACCTAAATGCC
TCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGCAACTCAAGTTCCACAGGATGGTCAAGCT
GTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTTGGGTTAGTTTTTTTTTTTTTTTTTGCTT
TGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAGAGATACATAAATGTGTGAATTTCCAGTT

>In-frame_ENST00000407008_ENST00000341056_TCGA-FG-A70Z-01A_NLK_chr17_26449758_+_ELMO1_chr7_37172839_length(amino acids)=561AA_start in transcript=718_stop in transcript=2403
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNNHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSE
TCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQE
DFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAV
VTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NLK-ELMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NLK-ELMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NLK-ELMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELMO1C0011881Diabetic Nephropathy1CTD_human
TgeneELMO1C0014518Toxic Epidermal Necrolysis1CTD_human
TgeneELMO1C0017667Nodular glomerulosclerosis1CTD_human
TgeneELMO1C0038325Stevens-Johnson Syndrome1CTD_human
TgeneELMO1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneELMO1C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneELMO1C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneELMO1C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human