FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NOL11-CARD11 (FusionGDB2 ID:59168)

Fusion Gene Summary for NOL11-CARD11

check button Fusion gene summary
Fusion gene informationFusion gene name: NOL11-CARD11
Fusion gene ID: 59168
HgeneTgene
Gene symbol

NOL11

CARD11

Gene ID

25926

84433

Gene namenucleolar protein 11caspase recruitment domain family member 11
Synonyms-BENTA|BIMP3|CARMA1|IMD11|IMD11A|PPBL
Cytomap

17q24.2

7p22.2

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 11caspase recruitment domain-containing protein 11CARD-containing MAGUK protein 1bcl10-interacting maguk protein 3carma 1
Modification date2020031320200313
UniProtAcc

Q9H8H0

Q9BXL7

Ensembl transtripts involved in fusion geneENST00000253247, ENST00000581966, 
ENST00000535137, 		ENST00000396946, 
Fusion gene scores* DoF score7 X 7 X 4=1964 X 4 X 4=64
# samples 74
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOL11 [Title/Abstract] AND CARD11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOL11(65733261)-CARD11(2979562), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCARD11

GO:0031295

T cell costimulation

17287217


check buttonFusion gene breakpoints across NOL11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CARD11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B3-01ANOL11chr17

65733261

+CARD11chr7

2979562

-
ChimerDB4BRCATCGA-BH-A0B3-01ANOL11chr17

65733261

+CARD11chr7

2979562

-
ChimerDB4BRCATCGA-BH-A0B3-01ANOL11chr17

65733261

-CARD11chr7

2979562

-


Top

Fusion Gene ORF analysis for NOL11-CARD11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000253247ENST00000396946NOL11chr17

65733261

+CARD11chr7

2979562

-
intron-3CDSENST00000581966ENST00000396946NOL11chr17

65733261

+CARD11chr7

2979562

-
In-frameENST00000535137ENST00000396946NOL11chr17

65733261

+CARD11chr7

2979562

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253247NOL11chr1765733261+ENST00000396946CARD11chr72979562-4611133310641131335
ENST00000535137NOL11chr1765733261+ENST00000396946CARD11chr72979562-4441116349139431150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253247ENST00000396946NOL11chr1765733261+CARD11chr72979562-0.0046016150.99539834
ENST00000535137ENST00000396946NOL11chr1765733261+CARD11chr72979562-0.0067997990.99320024

Top

Fusion Genomic Features for NOL11-CARD11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NOL11-CARD11


check button Go to

FGviewer for the breakpoints of chr17:65733261-chr7:2979562

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOL11

Q9H8H0

CARD11

Q9BXL7

FUNCTION: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000269|PubMed:22916032}.FUNCTION: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:28628108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCARD11chr17:65733261chr7:2979562ENST00000396946425667_755228.01155.0DomainNote=PDZ
TgeneCARD11chr17:65733261chr7:2979562ENST00000396946425973_1140228.01155.0DomainNote=Guanylate kinase-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCARD11chr17:65733261chr7:2979562ENST00000396946425130_449228.01155.0Coiled coilOntology_term=ECO:0000255
TgeneCARD11chr17:65733261chr7:2979562ENST0000039694642518_110228.01155.0DomainCARD


Top

Fusion Gene Sequence for NOL11-CARD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000253247_ENST00000396946_TCGA-BH-A0B3-01A_NOL11_chr17_65733261_+_CARD11_chr7_2979562_length(transcript)=4611nt_BP=1333nt
GCGAGAGCAGGTTCCTGGTTTGGCAAGCACTCGCCCCCTCAGGCCCGTTCATTCTCGCGAGAGAAAGCGCGAGGCCTGCCGGGAGTGAGC
GCGGCCGTACTTAGGTTTGCTCAAAATGGCAGCGCTGGAGGAAGAATTCACGTTGTCTTCGGTAGTCCTGAGCGCCGGGCCTGAAGGACT
CCTAGGCGTGGAGCAGAGCGACAAAACAGACCAGTTTCTAGTGACAGACAGCGGCAGGACAGTCATCCTCTATAAGGTTTCTGATCAGAA
ACCCTTGGGGAGCTGGTCAGTGAAACAAGGTCAAATTATAACATGTCCAGCTGTGTGCAACTTTCAAACTGGAGAGTATGTTGTTGTACA
CGATAATAAGGTTTTAAGAATATGGAATAATGAAGATGTAAACCTGGATAAAGTATTTAAAGCTACATTGTCAGCAGAAGTATATAGGAT
ACTTTCAGTGCAAGGGACAGAACCCTTGGTGCTCTTCAAGGAAGGTGCTGTTCGTGGTTTAGAGGCCTTGCTTGCAGACCCCCAGCAGAA
AATTGAAACTGTTATCTCTGATGAAGAAGTGATTAAATGGACAAAGTTTTTCGTAGTATTCAGACATCCTGTTTTAATTTTTATTACTGA
AAAACATGGAAATTACTTTGCTTACGTGCAAATGTTTAACTCACGTATCTTAACCAAATATACACTCTTACTTGGACAAGACGAAAACTC
TGTTATAAAGAGTTTTACTGCATCTGTAGATCGGAAATTCATCTCTTTGATGTCATTAAGCTCTGATGGTTGTATATATGAAACCTTGAT
ACCAATACGTCCAGCTGACCCAGAAAAAAATCAGAGCTTAGTTAAATCACTGCTGCTCAAGGCTGTTGTATCTGGTAACGCTCGAAATGG
AGTTGCACTCACTGCCCTGGATCAGGATCACGTCGCAGTCCTAGGAAGTCCACTAGCAGCTTCTAAGGAATGCCTCTCTGTATGGAACAT
AAAATTTCAAACACTACAGACTTCAAAAGAGTTACCACAAGGGACCAGTGGTCAACTCTGGTATTATGGAGAACATTTGTTTATGCTACA
TGGAAAATCTCTAACTGTGATTCCATACAAGTGTGAAGTGTCATCATTAGCAGGTGCTCTTGGAAAACTCAAGCATAGTCAAGATCCAGG
AACTCATGTCGTGTCCCATTTTGTAAACTGGGAGACACCTCAAGGATGTGGACTTGGGTTCCAGAACTCAGAGCAGTCAAGAAGAATTTT
AAGGAGACGAAAAATTGAAGTGAGTTTACAGCCAGAGGTTCCACCATCCAAACAACTTTTGTCAACCATAATGATCGATCAGCTAAAGCA
CCGGTTGAATAAGATGGAGGAGGAATGTAAGCTGGAGAGAAATCAGTCTCTAAAACTGAAGAATGACATTGAAAATCGGCCCAAGAAGGA
GCAGGTTCTGGAACTGGAGCGGGAGAATGAAATGCTGAAGACCAAAAACCAGGAGCTGCAGTCCATCATCCAGGCCGGGAAGCGCAGCCT
GCCAGACTCAGACAAGGCCATCCTGGACATCTTGGAACACGACCGCAAGGAGGCCCTGGAGGACAGGCAGGAGCTGGTCAACAGGATCTA
CAACCTGCAGGAGGAGGCCCGCCAGGCAGAGGAGCTGCGAGACAAGTACCTGGAGGAGAAGGAGGACCTGGAGCTCAAGTGCTCGACCCT
GGGAAAGGACTGTGAAATGTACAAGCACCGCATGAACACGGTCATGCTGCAGCTGGAGGAGGTGGAGCGGGAGCGGGACCAGGCCTTCCA
CTCCCGAGATGAAGCTCAGACACAGTACTCGCAGTGCTTAATCGAAAAGGACAAGTACAGGAAGCAGATCCGCGAGCTGGAGGAGAAGAA
CGACGAGATGAGGATCGAGATGGTGCGGCGGGAGGCCTGCATCGTCAACCTGGAGAGCAAGCTGCGGCGCCTCTCCAAGGACAGCAACAA
CCTGGACCAGAGTCTGCCCAGGAACCTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATGGTCAAGAAGC
TGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGAACCTGAAGGG
CATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAGGCACGGACGC
CAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCATGTCAATCAC
CGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACAATGACAGCGG
CGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCTCCTCCCACCA
ATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGCCTTCGGTCAC
CTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCACCCTGCTGGG
GGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACCAGCTGCTGCT
GCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGGACCATCCAGAGGTGCAG
CGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCACATCGGGGGA
CTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTGTGCACGTCCG
TGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGATATGGGCACCATACCCAG
CTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCACCCACCACAC
CCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGCGAGCAAGCTT
CCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCATCATCTCGGG
GAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTGAGAGCGAGCT
GGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACACCCACCGTGCT
GGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAAGAGATGAGTT
CCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCAACATTGAAGC
TGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACCCCATCGTGCT
CTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGCGCGTGTGCCG
GCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGCTGCTCCGCGT
TGTCAAGGACAAGATCGGCGAGGAGCAGCGCAAGACCATCTGGGTGGACGAGGACCAGCTGTGAGGCGGGCGCCCTGGGCAGAGAGACTC
TGTGGCGCGGGGCATCCTATGAGGCAGGCACCCTGGGCAGAGAGATGCAGTGGGTGCGGGGGGATCCTGTGGCCCACAGAGCTGCCCCAG
CAGACGCTCCGCCCCACCCGGTGATGGAGCCCCGGGGGGACAGTCGTGCCTGGGGAGGAGCAGGGTACAGCCCATTCCCCCAGCCCTGGC
TGACCTGGCCTAGCAGTTTGGCCCTGCTGGCCTTAGCAGGGAGACAGGGGAGCAAAGAACGCCAAGCCGGAGGCCCGAGGCCAGCCGGCC
TCTCGAGAGCCAGAGCAGCAGTTGAATGTAATGCTGGGGACAGGCATGCTGCCGCCAGTAGGGCGGGGACCCGGACAGCCAGGTGACTAC
CAGTCCTGGGGACACACTCACCATAAACACATCCCCAGGCAGGACAGATCGGGGAAGGGGTGTGTACCAGGCTATGATTTCTCTTGCATT

>In-frame_ENST00000253247_ENST00000396946_TCGA-BH-A0B3-01A_NOL11_chr17_65733261_+_CARD11_chr7_2979562_length(amino acids)=1335AA_start in transcript=106_stop in transcript=4113
MLKMAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVL
RIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNY
FAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTA
LDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVS
HFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLEL
ERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCE
MYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSL
PRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSC
GSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLD
AYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCI
RGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQ
DRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQL
LQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLV
QRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVC

--------------------------------------------------------------
>In-frame_ENST00000535137_ENST00000396946_TCGA-BH-A0B3-01A_NOL11_chr17_65733261_+_CARD11_chr7_2979562_length(transcript)=4441nt_BP=1163nt
AAAATGGCAGCGCTGGAGGAAGAATTCACGTTGTCTTCGGTAGTCCTGAGCGCCGGGCCTGAAGGACTCCTAGGCGTGGAGCAGAGCGAC
AAAACAGACCAGTTTCTAGTGACAGACAGCGGCAGGACAGTCATCCTCTATAAGGTTTCTGATCAGAAACCCTTGGGGAGCTGGTCAGTG
AAACAAGGTCAAATTATAACATGTCCAGCTGTGTGCAACTTTCAAACTGGAGAGTATGTTGTTGTACACGATAATAAGGTTTTAAGAATA
TGGAATAATGAAGATGTAAACCTGGATAAAGTATTTAAAGCTACATTGTCAGCAGAAGTATATAGGATACTTTCAGTGCAAGGGACAGAA
CCCTTGGTGCTCTTCAAGGAAGGTGCTGTTCGTGGTTTAGAGGCCTTGCTTGCAGACCCCCAGCAGAAAATTGAAACTGTTATCTCTGAT
GAAGAAGTGATTAACATGGAAATTACTTTGCTTACGTGCAAATGTTTAACTCACGTATCTTAACCAAATATACACTCTTACTTGGACAAG
ACGAAAACTCTGTTATAAAGAGTTTTACTGCATCTGTAGATCGGAAATTCATCTCTTTGATGTCATTAAGCTCTGATGGTTGTATATATG
AAACCTTGATACCAATACGTCCAGCTGACCCAGAAAAAAATCAGAGCTTAGTTAAATCACTGCTGCTCAAGGCTGTTGTATCTGGTAACG
CTCGAAATGGAGTTGCACTCACTGCCCTGGATCAGGATCACGTCGCAGTCCTAGGAAGTCCACTAGCAGCTTCTAAGGAATGCCTCTCTG
TATGGAACATAAAATTTCAAACACTACAGACTTCAAAAGAGTTACCACAAGGGACCAGTGGTCAACTCTGGTATTATGGAGAACATTTGT
TTATGCTACATGGAAAATCTCTAACTGTGATTCCATACAAGTGTGAAGTGTCATCATTAGCAGGTGCTCTTGGAAAACTCAAGCATAGTC
AAGATCCAGGAACTCATGTCGTGTCCCATTTTGTAAACTGGGAGACACCTCAAGGATGTGGACTTGGGTTCCAGAACTCAGAGCAGTCAA
GAAGAATTTTAAGGAGACGAAAAATTGAAGTGAGTTTACAGCCAGAGGTTCCACCATCCAAACAACTTTTGTCAACCATAATGATCGATC
AGCTAAAGCACCGGTTGAATAAGATGGAGGAGGAATGTAAGCTGGAGAGAAATCAGTCTCTAAAACTGAAGAATGACATTGAAAATCGGC
CCAAGAAGGAGCAGGTTCTGGAACTGGAGCGGGAGAATGAAATGCTGAAGACCAAAAACCAGGAGCTGCAGTCCATCATCCAGGCCGGGA
AGCGCAGCCTGCCAGACTCAGACAAGGCCATCCTGGACATCTTGGAACACGACCGCAAGGAGGCCCTGGAGGACAGGCAGGAGCTGGTCA
ACAGGATCTACAACCTGCAGGAGGAGGCCCGCCAGGCAGAGGAGCTGCGAGACAAGTACCTGGAGGAGAAGGAGGACCTGGAGCTCAAGT
GCTCGACCCTGGGAAAGGACTGTGAAATGTACAAGCACCGCATGAACACGGTCATGCTGCAGCTGGAGGAGGTGGAGCGGGAGCGGGACC
AGGCCTTCCACTCCCGAGATGAAGCTCAGACACAGTACTCGCAGTGCTTAATCGAAAAGGACAAGTACAGGAAGCAGATCCGCGAGCTGG
AGGAGAAGAACGACGAGATGAGGATCGAGATGGTGCGGCGGGAGGCCTGCATCGTCAACCTGGAGAGCAAGCTGCGGCGCCTCTCCAAGG
ACAGCAACAACCTGGACCAGAGTCTGCCCAGGAACCTGCCAGTAACCATCATCTCTCAGGACTTTGGGGATGCCAGCCCCAGGACCAATG
GTCAAGAAGCTGACGATTCTTCCACCTCGGAGGAGTCACCTGAAGACAGCAAGTACTTCCTGCCCTACCATCCGCCCCAGCGCAGGATGA
ACCTGAAGGGCATCCAGCTGCAGAGAGCCAAATCCCCCATCAGCCTGAAGCGAACATCAGATTTTCAAGCCAAGGGGCACGAGGAAGAAG
GCACGGACGCCAGCCCTAGCTCCTGCGGATCTCTGCCCATCACCAACTCCTTCACCAAGATGCAGCCCCCCCGGAGCCGCAGCAGCATCA
TGTCAATCACCGCCGAGCCCCCGGGAAACGACTCCATCGTCAGACGCTACAAGGAGGACGCGCCCCATCGCAGCACAGTCGAAGAAGACA
ATGACAGCGGCGGGTTTGACGCCTTAGATCTGGATGATGACAGTCACGAACGCTACTCCTTCGGACCCTCCTCCATCCACTCCTCCTCCT
CCTCCCACCAATCCGAGGGCCTGGATGCCTACGACCTGGAGCAGGTCAACCTCATGTTCAGGAAGTTCTCTCTGGAAAGACCCTTCCGGC
CTTCGGTCACCTCTGTGGGGCACGTGCGGGGCCCAGGGCCCTCGGTGCAGCACACGACGCTGAATGGCGACAGCCTCACCTCCCAGCTCA
CCCTGCTGGGGGGCAACGCGCGAGGGAGCTTCGTGCACTCGGTCAAGCCTGGCTCTCTGGCCGAGAAAGCCGGCCTCCGTGAGGGCCACC
AGCTGCTGCTGCTAGAAGGCTGCATCCGAGGCGAGAGGCAGAGTGTCCCGTTGGACACATGCACCAAAGAGGAAGCCCACTGGACCATCC
AGAGGTGCAGCGGCCCCGTCACGCTGCACTACAAGGTCAACCACGAAGGGTACCGGAAGCTGGTGAAGGACATGGAGGACGGCCTGATCA
CATCGGGGGACTCGTTCTACATCCGGCTGAACCTGAACATCTCCAGCCAGCTGGACGCCTGCACCATGTCCCTGAAGTGTGACGATGTTG
TGCACGTCCGTGACACCATGTACCAGGACAGGCACGAGTGGCTGTGCGCGCGGGTCGACCCTTTCACAGACCATGACCTGGATATGGGCA
CCATACCCAGCTACAGCCGAGCCCAGCAGCTCCTCCTGGTGAAACTGCAGCGCCTGATGCACCGAGGCAGCCGGGAGGAGGTAGACGGCA
CCCACCACACCCTGCGGGCACTCCGGAACACCCTGCAGCCAGAAGAAGCGCTTTCAACAAGCGACCCCCGGGTCAGCCCCCGTCTCTCGC
GAGCAAGCTTCCTTTTTGGCCAGCTCCTTCAGTTCGTCAGCAGGTCCGAGAACAAGTATAAGCGGATGAACAGCAACGAGCGGGTCCGCA
TCATCTCGGGGAGTCCGCTAGGGAGCCTGGCCCGGTCCTCGCTGGACGCCACCAAGCTCTTGACTGAGAAGCAGGAAGAGCTGGACCCTG
AGAGCGAGCTGGGCAAGAACCTCAGCCTCATCCCCTACAGCCTGGTACGCGCCTTCTACTGCGAGCGCCGCCGGCCCGTGCTCTTCACAC
CCACCGTGCTGGCCAAGACGCTGGTGCAGAGGCTGCTCAACTCGGGAGGTGCCATGGAGTTCACCATCTGCAAGTCAGATATCGTCACAA
GAGATGAGTTCCTCAGAAGGCAGAAGACGGAGACCATCATCTACTCCCGAGAGAAGAACCCCAACGCGTTCGAATGCATCGCCCCTGCCA
ACATTGAAGCTGTGGCCGCCAAGAACAAGCACTGCCTGCTGGAGGCTGGGATCGGCTGCACAAGAGACTTGATCAAGTCCAACATCTACC
CCATCGTGCTCTTCATCCGGGTGTGTGAGAAGAACATCAAGAGGTTCAGAAAGCTGCTGCCCCGACCTGAGACGGAGGAGGAGTTCCTGC
GCGTGTGCCGGCTGAAGGAGAAGGAGCTGGAGGCCCTGCCGTGCCTGTACGCCACGGTGGAACCTGACATGTGGGGCAGCGTAGAGGAGC
TGCTCCGCGTTGTCAAGGACAAGATCGGCGAGGAGCAGCGCAAGACCATCTGGGTGGACGAGGACCAGCTGTGAGGCGGGCGCCCTGGGC
AGAGAGACTCTGTGGCGCGGGGCATCCTATGAGGCAGGCACCCTGGGCAGAGAGATGCAGTGGGTGCGGGGGGATCCTGTGGCCCACAGA
GCTGCCCCAGCAGACGCTCCGCCCCACCCGGTGATGGAGCCCCGGGGGGACAGTCGTGCCTGGGGAGGAGCAGGGTACAGCCCATTCCCC
CAGCCCTGGCTGACCTGGCCTAGCAGTTTGGCCCTGCTGGCCTTAGCAGGGAGACAGGGGAGCAAAGAACGCCAAGCCGGAGGCCCGAGG
CCAGCCGGCCTCTCGAGAGCCAGAGCAGCAGTTGAATGTAATGCTGGGGACAGGCATGCTGCCGCCAGTAGGGCGGGGACCCGGACAGCC
AGGTGACTACCAGTCCTGGGGACACACTCACCATAAACACATCCCCAGGCAGGACAGATCGGGGAAGGGGTGTGTACCAGGCTATGATTT

>In-frame_ENST00000535137_ENST00000396946_TCGA-BH-A0B3-01A_NOL11_chr17_65733261_+_CARD11_chr7_2979562_length(amino acids)=1150AA_start in transcript=491_stop in transcript=3943
MFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDH
VAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNW
ETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENE
MLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHR
MNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLP
VTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPI
TNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLE
QVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQ
SVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEW
LCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVS
RSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLN
SGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NOL11-CARD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NOL11-CARD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NOL11-CARD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCARD11C4551967B-CELL EXPANSION WITH NFKB AND T-CELL ANERGY5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCARD11C3554686IMMUNODEFICIENCY 113CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneCARD11C0011615Dermatitis, Atopic2CTD_human
TgeneCARD11C0036920Sezary Syndrome2CTD_human
TgeneCARD11C0079744Diffuse Large B-Cell Lymphoma2CGI;CTD_human
TgeneCARD11C0086196Eczema, Infantile2CTD_human
TgeneCARD11C4539957IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS2GENOMICS_ENGLAND;UNIPROT
TgeneCARD11C0007134Renal Cell Carcinoma1CTD_human
TgeneCARD11C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneCARD11C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneCARD11C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneCARD11C0376407Granulomatous Slack Skin1CTD_human
TgeneCARD11C0494261Combined immunodeficiency1GENOMICS_ENGLAND
TgeneCARD11C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneCARD11C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneCARD11C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneCARD11C1306837Papillary Renal Cell Carcinoma1CTD_human