FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NOLC1-HTR7 (FusionGDB2 ID:59221)

Fusion Gene Summary for NOLC1-HTR7

check button Fusion gene summary
Fusion gene informationFusion gene name: NOLC1-HTR7
Fusion gene ID: 59221
HgeneTgene
Gene symbol

NOLC1

HTR7

Gene ID

9221

3363

Gene namenucleolar and coiled-body phosphoprotein 15-hydroxytryptamine receptor 7
SynonymsNOPP130|NOPP140|NS5ATP13|P130|Srp405-HT7
Cytomap

10q24.32

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionnucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp5-hydroxytryptamine receptor 75-HT-75-HT-X5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Modification date2020031320200313
UniProtAcc

Q14978

P34969

Ensembl transtripts involved in fusion geneENST00000605788, ENST00000405356, 
ENST00000603742, ENST00000488254, 
ENST00000477977, 		ENST00000371721, 
ENST00000277874, ENST00000336152, 
ENST00000371719, 
Fusion gene scores* DoF score7 X 7 X 2=981 X 1 X 1=1
# samples 71
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: NOLC1 [Title/Abstract] AND HTR7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOLC1(103912287)-HTR7(92509351), # samples:1
Anticipated loss of major functional domain due to fusion event.NOLC1-HTR7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NOLC1-HTR7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NOLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HTR7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NG-A4VU-01ANOLC1chr10

103912287

-HTR7chr10

92509351

-


Top

Fusion Gene ORF analysis for NOLC1-HTR7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000605788ENST00000371721NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000277874NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000336152NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000371719NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000371721NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000277874NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000336152NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000371719NOLC1chr10

103912287

-HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000371721NOLC1chr10

103912287

-HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000277874NOLC1chr10

103912287

-HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000336152NOLC1chr10

103912287

-HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000371719NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000371721NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000277874NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000336152NOLC1chr10

103912287

-HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000371719NOLC1chr10

103912287

-HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000371721NOLC1chr10

103912287

-HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000277874NOLC1chr10

103912287

-HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000336152NOLC1chr10

103912287

-HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000371719NOLC1chr10

103912287

-HTR7chr10

92509351

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for NOLC1-HTR7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NOLC1-HTR7


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOLC1

Q14978

HTR7

P34969

FUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for NOLC1-HTR7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for NOLC1-HTR7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NOLC1-HTR7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNOLC1Q14978DB00997DoxorubicinSmall moleculeApproved|Investigational
HgeneNOLC1Q14978DB00997DoxorubicinSmall moleculeApproved|Investigational
HgeneNOLC1Q14978DB00997DoxorubicinSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00246ZiprasidoneAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00247MethysergideAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00248CabergolineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00321AmitriptylineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00363ClozapineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00408LoxapineBinderSmall moleculeApproved
TgeneHTR7P34969DB00434CyproheptadineSmall moleculeApproved
TgeneHTR7P34969DB00458ImipramineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00502HaloperidolSmall moleculeApproved
TgeneHTR7P34969DB00543AmoxapineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00924CyclobenzaprineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00988DopamineBinderSmall moleculeApproved
TgeneHTR7P34969DB01224QuetiapineLigandSmall moleculeApproved
TgeneHTR7P34969DB01267PaliperidoneSmall moleculeApproved
TgeneHTR7P34969DB04946IloperidoneAntagonistSmall moleculeApproved
TgeneHTR7P34969DB06216AsenapineAntagonistSmall moleculeApproved
TgeneHTR7P34969DB00315ZolmitriptanAgonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00589LisurideSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00734RisperidoneAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00751EpinastineAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00934MaprotilineAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB01200BromocriptineAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB01238AripiprazoleAntagonist|Partial agonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB04948LofexidineAgonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB06148MianserinAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB06288AmisulprideAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB08815LurasidoneAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB09068VortioxetineAntagonistSmall moleculeApproved|Investigational
TgeneHTR7P34969DB14185Aripiprazole lauroxilSmall moleculeApproved|Investigational
TgeneHTR7P34969DB00477ChlorpromazineBinderSmall moleculeApproved|Investigational|Vet_approved
TgeneHTR7P34969DB09225ZotepineAntagonistSmall moleculeApproved|Investigational|Withdrawn

Top

Related Diseases for NOLC1-HTR7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHTR7C0011581Depressive disorder6CTD_human;PSYGENET
TgeneHTR7C0011570Mental Depression5PSYGENET
TgeneHTR7C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneHTR7C0003469Anxiety Disorders1CTD_human
TgeneHTR7C0011573Endogenous depression1CTD_human
TgeneHTR7C0023186Learning Disorders1CTD_human
TgeneHTR7C0025193Melancholia1CTD_human
TgeneHTR7C0025261Memory Disorders1CTD_human
TgeneHTR7C0026848Myopathy1CTD_human
TgeneHTR7C0030193Pain1CTD_human
TgeneHTR7C0036341Schizophrenia1CTD_human
TgeneHTR7C0041696Unipolar Depression1CTD_human
TgeneHTR7C0086133Depressive Syndrome1CTD_human
TgeneHTR7C0233794Memory impairment1CTD_human
TgeneHTR7C0234230Pain, Burning1CTD_human
TgeneHTR7C0234238Ache1CTD_human
TgeneHTR7C0234254Radiating pain1CTD_human
TgeneHTR7C0282126Depression, Neurotic1CTD_human
TgeneHTR7C0376280Anxiety States, Neurotic1CTD_human
TgeneHTR7C0458257Pain, Splitting1CTD_human
TgeneHTR7C0458259Pain, Crushing1CTD_human
TgeneHTR7C0525045Mood Disorders1PSYGENET
TgeneHTR7C0751262Adult Learning Disorders1CTD_human
TgeneHTR7C0751263Learning Disturbance1CTD_human
TgeneHTR7C0751265Learning Disabilities1CTD_human
TgeneHTR7C0751292Age-Related Memory Disorders1CTD_human
TgeneHTR7C0751293Memory Disorder, Semantic1CTD_human
TgeneHTR7C0751294Memory Disorder, Spatial1CTD_human
TgeneHTR7C0751295Memory Loss1CTD_human
TgeneHTR7C0751407Pain, Migratory1CTD_human
TgeneHTR7C0751408Suffering, Physical1CTD_human
TgeneHTR7C0751508Long Sleeper Syndrome1CTD_human
TgeneHTR7C0751509Short Sleeper Syndrome1CTD_human
TgeneHTR7C0751510Sleep-Related Neurogenic Tachypnea1CTD_human
TgeneHTR7C0751511Subwakefullness Syndrome1CTD_human
TgeneHTR7C0851578Sleep Disorders1CTD_human
TgeneHTR7C1279420Anxiety neurosis (finding)1CTD_human
TgeneHTR7C1330966Developmental Academic Disorder1CTD_human
TgeneHTR7C4042891Sleep Wake Disorders1CTD_human