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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOTCH1-HNF1B (FusionGDB2 ID:59348)

Fusion Gene Summary for NOTCH1-HNF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH1-HNF1B
Fusion gene ID: 59348
HgeneTgene
Gene symbol

NOTCH1

HNF1B

Gene ID

4851

6928

Gene namenotch receptor 1HNF1 homeobox B
SynonymsAOS5|AOVD1|TAN1|hN1FJHN|HNF-1-beta|HNF-1B|HNF1beta|HNF2|HPC11|LF-B3|LFB3|MODY5|TCF-2|TCF2|VHNF1
Cytomap

9q34.3

17q12

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatednotch 1translocation-associated notch protein TAN-1hepatocyte nuclear factor 1-betaHNF1 beta Ahomeoprotein LFB3transcription factor 2, hepatic
Modification date2020032920200313
UniProtAcc

P46531

P35680

Ensembl transtripts involved in fusion geneENST00000277541, ENST00000491649, 
ENST00000225893, ENST00000561193, 
ENST00000560016, ENST00000427275, 
Fusion gene scores* DoF score22 X 18 X 15=594012 X 10 X 8=960
# samples 2412
** MAII scorelog2(24/5940*10)=-4.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH1 [Title/Abstract] AND HNF1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHNF1B(36099431)-NOTCH1(139396940), # samples:2
NOTCH1(139397634)-HNF1B(36093736), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH1

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH1

GO:0007219

Notch signaling pathway

11306509

HgeneNOTCH1

GO:0008284

positive regulation of cell proliferation

17849174

HgeneNOTCH1

GO:0008285

negative regulation of cell proliferation

11306509|20616313

HgeneNOTCH1

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH1

GO:0010812

negative regulation of cell-substrate adhesion

16501043

HgeneNOTCH1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

20616313

HgeneNOTCH1

GO:0045944

positive regulation of transcription by RNA polymerase II

20616313

HgeneNOTCH1

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH1

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH1

GO:0071372

cellular response to follicle-stimulating hormone stimulus

20613903

HgeneNOTCH1

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

20616313

HgeneNOTCH1

GO:2001027

negative regulation of endothelial cell chemotaxis

20616313

TgeneHNF1B

GO:0001822

kidney development

21281489

TgeneHNF1B

GO:0045893

positive regulation of transcription, DNA-templated

16297991|21281489

TgeneHNF1B

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

15355349


check buttonFusion gene breakpoints across NOTCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNF1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-BQ-7053NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
ChimerDB4KIRPTCGA-BQ-7053NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
ChimerDB4KIRPTCGA-BQ-7053NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
ChimerDB4KIRPTCGA-BQ-7053NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
ChimerDB4KIRPTCGA-BQ-7053-01ANOTCH1chr9

139397634

-HNF1Bchr17

36093736

-


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Fusion Gene ORF analysis for NOTCH1-HNF1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000277541ENST00000225893NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000561193NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000560016NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000427275NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000225893NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000561193NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000560016NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000427275NOTCH1chr9

139397633

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000225893NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000561193NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000560016NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000427275NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
intron-3CDSENST00000491649ENST00000225893NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000561193NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000560016NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000427275NOTCH1chr9

139397633

-HNF1Bchr17

36093814

-
In-frameENST00000277541ENST00000225893NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000561193NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000560016NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000427275NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000225893NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000561193NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000560016NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
intron-3CDSENST00000491649ENST00000427275NOTCH1chr9

139397634

-HNF1Bchr17

36093736

-
In-frameENST00000277541ENST00000225893NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000561193NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000560016NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
5CDS-intronENST00000277541ENST00000427275NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
intron-3CDSENST00000491649ENST00000225893NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000561193NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000560016NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-
intron-intronENST00000491649ENST00000427275NOTCH1chr9

139397634

-HNF1Bchr17

36093814

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277541NOTCH1chr9139397633-ENST00000225893HNF1Bchr1736093736-723552437653551759
ENST00000277541NOTCH1chr9139397633-ENST00000561193HNF1Bchr1736093736-649552437662942072
ENST00000277541NOTCH1chr9139397633-ENST00000560016HNF1Bchr1736093736-630652437653551759
ENST00000277541NOTCH1chr9139397633-ENST00000427275HNF1Bchr1736093736-611152437660721998
ENST00000277541NOTCH1chr9139397633-ENST00000225893HNF1Bchr1736093814-731352437663722098
ENST00000277541NOTCH1chr9139397634-ENST00000225893HNF1Bchr1736093736-723552437653551759
ENST00000277541NOTCH1chr9139397634-ENST00000561193HNF1Bchr1736093736-649552437662942072
ENST00000277541NOTCH1chr9139397634-ENST00000560016HNF1Bchr1736093736-630652437653551759
ENST00000277541NOTCH1chr9139397634-ENST00000427275HNF1Bchr1736093736-611152437660721998
ENST00000277541NOTCH1chr9139397634-ENST00000225893HNF1Bchr1736093814-731352437663722098

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277541ENST00000225893NOTCH1chr9139397633-HNF1Bchr1736093736-0.0029087110.9970913
ENST00000277541ENST00000561193NOTCH1chr9139397633-HNF1Bchr1736093736-0.0050541870.9949458
ENST00000277541ENST00000560016NOTCH1chr9139397633-HNF1Bchr1736093736-0.0044505490.99554944
ENST00000277541ENST00000427275NOTCH1chr9139397633-HNF1Bchr1736093736-0.0038191210.9961809
ENST00000277541ENST00000225893NOTCH1chr9139397633-HNF1Bchr1736093814-0.0028931150.99710685
ENST00000277541ENST00000225893NOTCH1chr9139397634-HNF1Bchr1736093736-0.0029087110.9970913
ENST00000277541ENST00000561193NOTCH1chr9139397634-HNF1Bchr1736093736-0.0050541870.9949458
ENST00000277541ENST00000560016NOTCH1chr9139397634-HNF1Bchr1736093736-0.0044505490.99554944
ENST00000277541ENST00000427275NOTCH1chr9139397634-HNF1Bchr1736093736-0.0038191210.9961809
ENST00000277541ENST00000225893NOTCH1chr9139397634-HNF1Bchr1736093814-0.0028931150.99710685

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Fusion Genomic Features for NOTCH1-HNF1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOTCH1-HNF1B


check button Go to

FGviewer for the breakpoints of chr9:139397633-chr17:36093736

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH1

P46531

HNF1B

P35680

FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.FUNCTION: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341575_15781722.33333333333332556.0Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341661_16641722.33333333333332556.0Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341575_15781722.33333333333332556.0Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341661_16641722.33333333333332556.0Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341575_15781722.33333333333332556.0Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341661_16641722.33333333333332556.0Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341575_15781722.33333333333332556.0Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341661_16641722.33333333333332556.0Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341021_10571722.33333333333332556.0DomainEGF-like 27
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734102_1391722.33333333333332556.0DomainEGF-like 3
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341059_10951722.33333333333332556.0DomainEGF-like 28
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341097_11431722.33333333333332556.0DomainEGF-like 29
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341145_11811722.33333333333332556.0DomainEGF-like 30
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341183_12191722.33333333333332556.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341221_12651722.33333333333332556.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341267_13051722.33333333333332556.0DomainEGF-like 33
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341307_13461722.33333333333332556.0DomainEGF-like 34
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341348_13841722.33333333333332556.0DomainEGF-like 35
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341387_14261722.33333333333332556.0DomainEGF-like 36
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734140_1761722.33333333333332556.0DomainEGF-like 4
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734178_2161722.33333333333332556.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-273420_581722.33333333333332556.0DomainEGF-like 1
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734218_2551722.33333333333332556.0DomainEGF-like 6
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734257_2931722.33333333333332556.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734295_3331722.33333333333332556.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734335_3711722.33333333333332556.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734372_4101722.33333333333332556.0DomainEGF-like 10
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734412_4501722.33333333333332556.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734452_4881722.33333333333332556.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734490_5261722.33333333333332556.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734528_5641722.33333333333332556.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734566_6011722.33333333333332556.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-273459_991722.33333333333332556.0DomainEGF-like 2
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734603_6391722.33333333333332556.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734641_6761722.33333333333332556.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734678_7141722.33333333333332556.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734716_7511722.33333333333332556.0DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734753_7891722.33333333333332556.0DomainEGF-like 20
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734791_8271722.33333333333332556.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734829_8671722.33333333333332556.0DomainEGF-like 22
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734869_9051722.33333333333332556.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734907_9431722.33333333333332556.0DomainEGF-like 24
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734945_9811722.33333333333332556.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734983_10191722.33333333333332556.0DomainEGF-like 26
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341021_10571722.33333333333332556.0DomainEGF-like 27
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734102_1391722.33333333333332556.0DomainEGF-like 3
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341059_10951722.33333333333332556.0DomainEGF-like 28
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341097_11431722.33333333333332556.0DomainEGF-like 29
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341145_11811722.33333333333332556.0DomainEGF-like 30
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341183_12191722.33333333333332556.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341221_12651722.33333333333332556.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341267_13051722.33333333333332556.0DomainEGF-like 33
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341307_13461722.33333333333332556.0DomainEGF-like 34
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341348_13841722.33333333333332556.0DomainEGF-like 35
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341387_14261722.33333333333332556.0DomainEGF-like 36
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734140_1761722.33333333333332556.0DomainEGF-like 4
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734178_2161722.33333333333332556.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-273420_581722.33333333333332556.0DomainEGF-like 1
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734218_2551722.33333333333332556.0DomainEGF-like 6
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734257_2931722.33333333333332556.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734295_3331722.33333333333332556.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734335_3711722.33333333333332556.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734372_4101722.33333333333332556.0DomainEGF-like 10
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734412_4501722.33333333333332556.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734452_4881722.33333333333332556.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734490_5261722.33333333333332556.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734528_5641722.33333333333332556.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734566_6011722.33333333333332556.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-273459_991722.33333333333332556.0DomainEGF-like 2
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734603_6391722.33333333333332556.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734641_6761722.33333333333332556.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734678_7141722.33333333333332556.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734716_7511722.33333333333332556.0DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734753_7891722.33333333333332556.0DomainEGF-like 20
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734791_8271722.33333333333332556.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734829_8671722.33333333333332556.0DomainEGF-like 22
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734869_9051722.33333333333332556.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734907_9431722.33333333333332556.0DomainEGF-like 24
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734945_9811722.33333333333332556.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734983_10191722.33333333333332556.0DomainEGF-like 26
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341021_10571722.33333333333332556.0DomainEGF-like 27
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734102_1391722.33333333333332556.0DomainEGF-like 3
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341059_10951722.33333333333332556.0DomainEGF-like 28
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341097_11431722.33333333333332556.0DomainEGF-like 29
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341145_11811722.33333333333332556.0DomainEGF-like 30
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341183_12191722.33333333333332556.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341221_12651722.33333333333332556.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341267_13051722.33333333333332556.0DomainEGF-like 33
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341307_13461722.33333333333332556.0DomainEGF-like 34
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341348_13841722.33333333333332556.0DomainEGF-like 35
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341387_14261722.33333333333332556.0DomainEGF-like 36
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734140_1761722.33333333333332556.0DomainEGF-like 4
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734178_2161722.33333333333332556.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-273420_581722.33333333333332556.0DomainEGF-like 1
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734218_2551722.33333333333332556.0DomainEGF-like 6
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734257_2931722.33333333333332556.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734295_3331722.33333333333332556.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734335_3711722.33333333333332556.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734372_4101722.33333333333332556.0DomainEGF-like 10
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734412_4501722.33333333333332556.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734452_4881722.33333333333332556.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734490_5261722.33333333333332556.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734528_5641722.33333333333332556.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734566_6011722.33333333333332556.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-273459_991722.33333333333332556.0DomainEGF-like 2
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734603_6391722.33333333333332556.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734641_6761722.33333333333332556.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734678_7141722.33333333333332556.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734716_7511722.33333333333332556.0DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734753_7891722.33333333333332556.0DomainEGF-like 20
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734791_8271722.33333333333332556.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734829_8671722.33333333333332556.0DomainEGF-like 22
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734869_9051722.33333333333332556.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734907_9431722.33333333333332556.0DomainEGF-like 24
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734945_9811722.33333333333332556.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734983_10191722.33333333333332556.0DomainEGF-like 26
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341021_10571722.33333333333332556.0DomainEGF-like 27
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734102_1391722.33333333333332556.0DomainEGF-like 3
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341059_10951722.33333333333332556.0DomainEGF-like 28
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341097_11431722.33333333333332556.0DomainEGF-like 29
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341145_11811722.33333333333332556.0DomainEGF-like 30
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341183_12191722.33333333333332556.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341221_12651722.33333333333332556.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341267_13051722.33333333333332556.0DomainEGF-like 33
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341307_13461722.33333333333332556.0DomainEGF-like 34
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341348_13841722.33333333333332556.0DomainEGF-like 35
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341387_14261722.33333333333332556.0DomainEGF-like 36
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734140_1761722.33333333333332556.0DomainEGF-like 4
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734178_2161722.33333333333332556.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-273420_581722.33333333333332556.0DomainEGF-like 1
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734218_2551722.33333333333332556.0DomainEGF-like 6
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734257_2931722.33333333333332556.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734295_3331722.33333333333332556.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734335_3711722.33333333333332556.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734372_4101722.33333333333332556.0DomainEGF-like 10
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734412_4501722.33333333333332556.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734452_4881722.33333333333332556.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734490_5261722.33333333333332556.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734528_5641722.33333333333332556.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734566_6011722.33333333333332556.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-273459_991722.33333333333332556.0DomainEGF-like 2
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734603_6391722.33333333333332556.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734641_6761722.33333333333332556.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734678_7141722.33333333333332556.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734716_7511722.33333333333332556.0DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734753_7891722.33333333333332556.0DomainEGF-like 20
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734791_8271722.33333333333332556.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734829_8671722.33333333333332556.0DomainEGF-like 22
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734869_9051722.33333333333332556.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734907_9431722.33333333333332556.0DomainEGF-like 24
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734945_9811722.33333333333332556.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734983_10191722.33333333333332556.0DomainEGF-like 26
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341449_14891722.33333333333332556.0RepeatLNR 1
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341490_15311722.33333333333332556.0RepeatLNR 2
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341532_15711722.33333333333332556.0RepeatLNR 3
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341449_14891722.33333333333332556.0RepeatLNR 1
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341490_15311722.33333333333332556.0RepeatLNR 2
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341532_15711722.33333333333332556.0RepeatLNR 3
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341449_14891722.33333333333332556.0RepeatLNR 1
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341490_15311722.33333333333332556.0RepeatLNR 2
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341532_15711722.33333333333332556.0RepeatLNR 3
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341449_14891722.33333333333332556.0RepeatLNR 1
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341490_15311722.33333333333332556.0RepeatLNR 2
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341532_15711722.33333333333332556.0RepeatLNR 3
TgeneHNF1Bchr9:139397633chr17:36093736ENST0000022589309231_3110558.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093736ENST0000042727517231_311181.33333333333334458.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093736ENST0000056119319231_311181.33333333333334532.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093814ENST0000022589319231_311181.33333333333334558.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093814ENST0000042727507231_3110458.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093814ENST0000056119309231_3110532.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093736ENST0000022589309231_3110558.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093736ENST0000042727517231_311181.33333333333334458.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093736ENST0000056119319231_311181.33333333333334532.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093814ENST0000022589319231_311181.33333333333334558.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093814ENST0000042727507231_3110458.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397634chr17:36093814ENST0000056119309231_3110532.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000225893091_320558.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093736ENST000002258930993_1880558.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000427275071_320458.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093814ENST000004272750793_1880458.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000561193091_320532.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093814ENST000005611930993_1880532.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000225893091_320558.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093736ENST000002258930993_1880558.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000427275071_320458.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093814ENST000004272750793_1880458.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000561193091_320532.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093814ENST000005611930993_1880532.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000225893091_310558.0RegionDimerization
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000427275071_310458.0RegionDimerization
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000561193091_310532.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000225893091_310558.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000427275071_310458.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000561193091_310532.0RegionDimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341728_17311722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341740_17431722.33333333333332556.0Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341901_19041722.33333333333332556.0Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342259_22621722.33333333333332556.0Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342403_24061722.33333333333332556.0Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342410_24171722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342521_25241722.33333333333332556.0Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341728_17311722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341740_17431722.33333333333332556.0Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341901_19041722.33333333333332556.0Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342259_22621722.33333333333332556.0Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342403_24061722.33333333333332556.0Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342410_24171722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342521_25241722.33333333333332556.0Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341728_17311722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341740_17431722.33333333333332556.0Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341901_19041722.33333333333332556.0Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342259_22621722.33333333333332556.0Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342403_24061722.33333333333332556.0Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342410_24171722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342521_25241722.33333333333332556.0Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341728_17311722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341740_17431722.33333333333332556.0Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341901_19041722.33333333333332556.0Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342259_22621722.33333333333332556.0Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342403_24061722.33333333333332556.0Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342410_24171722.33333333333332556.0Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342521_25241722.33333333333332556.0Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341947_19551722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342014_20221722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341947_19551722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342014_20221722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341947_19551722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342014_20221722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341947_19551722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342014_20221722.33333333333332556.0RegionHIF1AN-binding
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341927_19561722.33333333333332556.0RepeatANK 1
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341960_19901722.33333333333332556.0RepeatANK 2
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341994_20231722.33333333333332556.0RepeatANK 3
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342027_20561722.33333333333332556.0RepeatANK 4
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342060_20891722.33333333333332556.0RepeatANK 5
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27342095_21221722.33333333333332556.0RepeatNote=ANK 6
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341927_19561722.33333333333332556.0RepeatANK 1
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341960_19901722.33333333333332556.0RepeatANK 2
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341994_20231722.33333333333332556.0RepeatANK 3
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342027_20561722.33333333333332556.0RepeatANK 4
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342060_20891722.33333333333332556.0RepeatANK 5
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27342095_21221722.33333333333332556.0RepeatNote=ANK 6
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341927_19561722.33333333333332556.0RepeatANK 1
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341960_19901722.33333333333332556.0RepeatANK 2
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341994_20231722.33333333333332556.0RepeatANK 3
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342027_20561722.33333333333332556.0RepeatANK 4
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342060_20891722.33333333333332556.0RepeatANK 5
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27342095_21221722.33333333333332556.0RepeatNote=ANK 6
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341927_19561722.33333333333332556.0RepeatANK 1
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341960_19901722.33333333333332556.0RepeatANK 2
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341994_20231722.33333333333332556.0RepeatANK 3
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342027_20561722.33333333333332556.0RepeatANK 4
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342060_20891722.33333333333332556.0RepeatANK 5
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27342095_21221722.33333333333332556.0RepeatNote=ANK 6
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341757_25551722.33333333333332556.0Topological domainCytoplasmic
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-273419_17351722.33333333333332556.0Topological domainExtracellular
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341757_25551722.33333333333332556.0Topological domainCytoplasmic
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-273419_17351722.33333333333332556.0Topological domainExtracellular
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341757_25551722.33333333333332556.0Topological domainCytoplasmic
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-273419_17351722.33333333333332556.0Topological domainExtracellular
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341757_25551722.33333333333332556.0Topological domainCytoplasmic
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-273419_17351722.33333333333332556.0Topological domainExtracellular
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341736_17561722.33333333333332556.0TransmembraneHelical
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341736_17561722.33333333333332556.0TransmembraneHelical
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341736_17561722.33333333333332556.0TransmembraneHelical
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341736_17561722.33333333333332556.0TransmembraneHelical
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000427275171_32181.33333333333334458.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093736ENST000004272751793_188181.33333333333334458.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000561193191_32181.33333333333334532.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093736ENST000005611931993_188181.33333333333334532.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000225893191_32181.33333333333334558.0DomainHNF-p1
TgeneHNF1Bchr9:139397633chr17:36093814ENST000002258931993_188181.33333333333334558.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000427275171_32181.33333333333334458.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093736ENST000004272751793_188181.33333333333334458.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000561193191_32181.33333333333334532.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093736ENST000005611931993_188181.33333333333334532.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000225893191_32181.33333333333334558.0DomainHNF-p1
TgeneHNF1Bchr9:139397634chr17:36093814ENST000002258931993_188181.33333333333334558.0DomainPOU-specific atypical
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000427275171_31181.33333333333334458.0RegionDimerization
TgeneHNF1Bchr9:139397633chr17:36093736ENST00000561193191_31181.33333333333334532.0RegionDimerization
TgeneHNF1Bchr9:139397633chr17:36093814ENST00000225893191_31181.33333333333334558.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000427275171_31181.33333333333334458.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093736ENST00000561193191_31181.33333333333334532.0RegionDimerization
TgeneHNF1Bchr9:139397634chr17:36093814ENST00000225893191_31181.33333333333334558.0RegionDimerization


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Fusion Gene Sequence for NOTCH1-HNF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(transcript)=7235nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTT
TCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGGACGT
CCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCCCAGTTTCCCTTCTATGCAGTATTGCCACAATGCCTCTCCCA
CGATGTCAAGGACTCCTGTCTGTCCTGGAGGTGGGAGACAAGGAACCACCGAAGAGGAAGCAAGAAAGCCGTACTGTCTATGTTGTGATC
CTTCATCGAACAAACTGATGCGAAAACTTGAATCTGTTACTGAAATGAGGAGAGAAGGACATGTGCTATTGAACTGAGCCAAACACACTG
TAAATATCCACAGACTCCCTCCCCTGCCCCCATCCCACATGATCTTGAGATTTCTTTTAAAGAAGTAAATTTGTCCAATGGCTGTAAACT
ATAAACTACTGTAATTAAGTGCAATTTCCCCTCTGTGTCCTCTCCCCTCTGCCCTGTATATAATACTAAAGTGTCTATTAGTTTTCTTTG
TAAAGGTCAGAGTCAAAATTTCAAAAGTGATCTGTCCCCTCTCCCCTCATGGAGAAACATCCTAAGTGGGAAGTGAAGCCCCTTGTCCTC
TCCCGCGGGCCTGGACACTTATGGGGACAGCATACCTTGGACTGACTACCAGCTAACTCCAGTCTCCTGACATTAAGACACACCTCTGGA
TCCCTGGAGGGGCTGAATGTAGTGTGTCAGAGTAACATGCCAGCTTCCTGTGGGCCAGGAGCTCAGCCGTGCACTCCCTAAGAAACCCCA
GGGCAGGGAAACTGGCTGTTTGATAGCAGAAGAAAAAGTTGCAGTCTCAGAAAGCCTTCCATTAAAACAATTTATTTTATCACTTGTACG
CACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGTCACAGATACCAGCAGCATCAGTACACTCA
CCAACATGTCTTCAAGTAAACAGGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCT
GCAGCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCC
CTTCATGGCAGCTGTGACTCAGCTGCAGAACTCACACAATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCC
ACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGAGTGCGCT
ACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTAC
AGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGGGCAGAATGTTTGCAGCGAGGGGTGTCC
CCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTC
CGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCC
AGCTCCTCTCCTCCAAACAAGCTGTCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAAC
AAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAG

>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(amino acids)=1759AA_start in transcript=76_stop in transcript=5355
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000561193_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(transcript)=6495nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAA
GATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGA
GAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTT
GGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTC
CAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGT
GCGCTACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGT
TTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTT
GCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGG
AGTCATGGCAATTGCACAAAGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCA
GCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTT
CATGGCAGCTGTGACTCAGCTGCAGAACTCACACATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATC
TGCAATGGTGGTCACAGATACCAGCAGCATCAGTACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCC
ACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCT
GACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGGACGTCCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCC

>In-frame_ENST00000277541_ENST00000561193_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(amino acids)=2072AA_start in transcript=76_stop in transcript=6294
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHG
LGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMV
TSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGS
LAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQ

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000560016_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(transcript)=6306nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTT
TCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGCCTCA
ACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTTCTCCCAGCAGCTGC
ACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGTGACTCAGCTGCAGA
ACTCACACAATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAA
TCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGAGTGCGCTACAGCCAGCAGGGAAACAATGAGATCACT
TCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCA
GGCCACAATCTCCTCTCACCTGATGGTAAAATGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAA
CTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAG
CTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGA
GTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATG
GGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATG

>In-frame_ENST00000277541_ENST00000560016_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(amino acids)=1759AA_start in transcript=76_stop in transcript=5355
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000427275_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(transcript)=6111nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAA
GATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGA
GAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTT
GGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTC
CAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGT
GCGCTACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGT
TTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTT
GCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGG
AGTCATGGCAATTGCACAAATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCC

>In-frame_ENST00000277541_ENST00000427275_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093736_length(amino acids)=1998AA_start in transcript=76_stop in transcript=6072
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHG
LGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMV
TSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQMSSTSLVMPTHHLLRAQQQ

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093814_length(transcript)=7313nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTT
TCTCTTTCCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAA
CCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTT
AGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGT
CCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCA
CAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGTGCGCTACAGCCA
GCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTACAGCAAGT
CTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAG
CACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAAT
TGCACAAAGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTT
CTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGT
GACTCAGCTGCAGAACTCACACATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGT
CACAGATACCAGCAGCATCAGTACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTA
CTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTG
CGAGAGGTCCCTGCTTACCTGACGGACGTCCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCCCAGTTTCCCTTC
TATGCAGTATTGCCACAATGCCTCTCCCACGATGTCAAGGACTCCTGTCTGTCCTGGAGGTGGGAGACAAGGAACCACCGAAGAGGAAGC
AAGAAAGCCGTACTGTCTATGTTGTGATCCTTCATCGAACAAACTGATGCGAAAACTTGAATCTGTTACTGAAATGAGGAGAGAAGGACA
TGTGCTATTGAACTGAGCCAAACACACTGTAAATATCCACAGACTCCCTCCCCTGCCCCCATCCCACATGATCTTGAGATTTCTTTTAAA
GAAGTAAATTTGTCCAATGGCTGTAAACTATAAACTACTGTAATTAAGTGCAATTTCCCCTCTGTGTCCTCTCCCCTCTGCCCTGTATAT
AATACTAAAGTGTCTATTAGTTTTCTTTGTAAAGGTCAGAGTCAAAATTTCAAAAGTGATCTGTCCCCTCTCCCCTCATGGAGAAACATC
CTAAGTGGGAAGTGAAGCCCCTTGTCCTCTCCCGCGGGCCTGGACACTTATGGGGACAGCATACCTTGGACTGACTACCAGCTAACTCCA
GTCTCCTGACATTAAGACACACCTCTGGATCCCTGGAGGGGCTGAATGTAGTGTGTCAGAGTAACATGCCAGCTTCCTGTGGGCCAGGAG
CTCAGCCGTGCACTCCCTAAGAAACCCCAGGGCAGGGAAACTGGCTGTTTGATAGCAGAAGAAAAAGTTGCAGTCTCAGAAAGCCTTCCA

>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397633_-_HNF1B_chr17_36093814_length(amino acids)=2098AA_start in transcript=76_stop in transcript=6372
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKE
EREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSG
VRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLS
GVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFP

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(transcript)=7235nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTT
TCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGGACGT
CCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCCCAGTTTCCCTTCTATGCAGTATTGCCACAATGCCTCTCCCA
CGATGTCAAGGACTCCTGTCTGTCCTGGAGGTGGGAGACAAGGAACCACCGAAGAGGAAGCAAGAAAGCCGTACTGTCTATGTTGTGATC
CTTCATCGAACAAACTGATGCGAAAACTTGAATCTGTTACTGAAATGAGGAGAGAAGGACATGTGCTATTGAACTGAGCCAAACACACTG
TAAATATCCACAGACTCCCTCCCCTGCCCCCATCCCACATGATCTTGAGATTTCTTTTAAAGAAGTAAATTTGTCCAATGGCTGTAAACT
ATAAACTACTGTAATTAAGTGCAATTTCCCCTCTGTGTCCTCTCCCCTCTGCCCTGTATATAATACTAAAGTGTCTATTAGTTTTCTTTG
TAAAGGTCAGAGTCAAAATTTCAAAAGTGATCTGTCCCCTCTCCCCTCATGGAGAAACATCCTAAGTGGGAAGTGAAGCCCCTTGTCCTC
TCCCGCGGGCCTGGACACTTATGGGGACAGCATACCTTGGACTGACTACCAGCTAACTCCAGTCTCCTGACATTAAGACACACCTCTGGA
TCCCTGGAGGGGCTGAATGTAGTGTGTCAGAGTAACATGCCAGCTTCCTGTGGGCCAGGAGCTCAGCCGTGCACTCCCTAAGAAACCCCA
GGGCAGGGAAACTGGCTGTTTGATAGCAGAAGAAAAAGTTGCAGTCTCAGAAAGCCTTCCATTAAAACAATTTATTTTATCACTTGTACG
CACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGTCACAGATACCAGCAGCATCAGTACACTCA
CCAACATGTCTTCAAGTAAACAGGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCT
GCAGCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCC
CTTCATGGCAGCTGTGACTCAGCTGCAGAACTCACACAATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCC
ACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGAGTGCGCT
ACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTAC
AGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGGGCAGAATGTTTGCAGCGAGGGGTGTCC
CCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTC
CGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCC
AGCTCCTCTCCTCCAAACAAGCTGTCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAAC
AAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAG

>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(amino acids)=1759AA_start in transcript=76_stop in transcript=5355
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000561193_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(transcript)=6495nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAA
GATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGA
GAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTT
GGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTC
CAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGT
GCGCTACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGT
TTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTT
GCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGG
AGTCATGGCAATTGCACAAAGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCA
GCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTT
CATGGCAGCTGTGACTCAGCTGCAGAACTCACACATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATC
TGCAATGGTGGTCACAGATACCAGCAGCATCAGTACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCC
ACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCT
GACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGGACGTCCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCC

>In-frame_ENST00000277541_ENST00000561193_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(amino acids)=2072AA_start in transcript=76_stop in transcript=6294
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHG
LGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMV
TSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGS
LAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQ

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000560016_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(transcript)=6306nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTT
TCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGACGCCTCA
ACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTTCTCCCAGCAGCTGC
ACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGTGACTCAGCTGCAGA
ACTCACACAATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAA
TCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGAGTGCGCTACAGCCAGCAGGGAAACAATGAGATCACT
TCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCA
GGCCACAATCTCCTCTCACCTGATGGTAAAATGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAA
CTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAG
CTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGA
GTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATG
GGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATG

>In-frame_ENST00000277541_ENST00000560016_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(amino acids)=1759AA_start in transcript=76_stop in transcript=5355
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000427275_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(transcript)=6111nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAA
GATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGA
GAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTT
GGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTC
CAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGT
GCGCTACAGCCAGCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGT
TTTACAGCAAGTCTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTT
GCCCCCAGTCAGCACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGG
AGTCATGGCAATTGCACAAATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCC

>In-frame_ENST00000277541_ENST00000427275_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093736_length(amino acids)=1998AA_start in transcript=76_stop in transcript=6072
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHG
LGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMV
TSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQMSSTSLVMPTHHLLRAQQQ

--------------------------------------------------------------
>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093814_length(transcript)=7313nt_BP=5243nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTA
CCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTA
CAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAG
CCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGA
GGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTG
CCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGC
CTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCT
GCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTT
CCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCT
GTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGAT
CGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGA
CGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTG
TGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTA
CTGCAAGGACCACTTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTGGACTGTGCGGAGCATGT
ACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTGATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGA
GCTCAGCCGCGTGCTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTACTACGGCCGCGAGGAGGA
GCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCCGCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGG
TGGCAGCGAGGGTGGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAGATTGACAACCGGCAGTG
TGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTGGCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCC
CTACAAGATCGAGGCCGTGCAGAAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTT
TCTCTTTCCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAA
CCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTT
AGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGT
CCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCA
CAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGGAGTGCGCTACAGCCA
GCAGGGAAACAATGAGATCACTTCCTCCTCAACAATCAGTCACCATGGCAACAGCGCCATGGTGACCAGCCAGTCGGTTTTACAGCAAGT
CTCCCCAGCCAGCCTGGACCCAGGCCACAATCTCCTCTCACCTGATGGTAAAATGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAG
CACCTTGACGAATATCCACAGCCTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAAT
TGCACAAAGCCTCAACACCTCCCAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTT
CTCCCAGCAGCTGCACAGCCCTCACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGT
GACTCAGCTGCAGAACTCACACATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGT
CACAGATACCAGCAGCATCAGTACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTA
CTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTG
CGAGAGGTCCCTGCTTACCTGACGGACGTCCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCCCAGTTTCCCTTC
TATGCAGTATTGCCACAATGCCTCTCCCACGATGTCAAGGACTCCTGTCTGTCCTGGAGGTGGGAGACAAGGAACCACCGAAGAGGAAGC
AAGAAAGCCGTACTGTCTATGTTGTGATCCTTCATCGAACAAACTGATGCGAAAACTTGAATCTGTTACTGAAATGAGGAGAGAAGGACA
TGTGCTATTGAACTGAGCCAAACACACTGTAAATATCCACAGACTCCCTCCCCTGCCCCCATCCCACATGATCTTGAGATTTCTTTTAAA
GAAGTAAATTTGTCCAATGGCTGTAAACTATAAACTACTGTAATTAAGTGCAATTTCCCCTCTGTGTCCTCTCCCCTCTGCCCTGTATAT
AATACTAAAGTGTCTATTAGTTTTCTTTGTAAAGGTCAGAGTCAAAATTTCAAAAGTGATCTGTCCCCTCTCCCCTCATGGAGAAACATC
CTAAGTGGGAAGTGAAGCCCCTTGTCCTCTCCCGCGGGCCTGGACACTTATGGGGACAGCATACCTTGGACTGACTACCAGCTAACTCCA
GTCTCCTGACATTAAGACACACCTCTGGATCCCTGGAGGGGCTGAATGTAGTGTGTCAGAGTAACATGCCAGCTTCCTGTGGGCCAGGAG
CTCAGCCGTGCACTCCCTAAGAAACCCCAGGGCAGGGAAACTGGCTGTTTGATAGCAGAAGAAAAAGTTGCAGTCTCAGAAAGCCTTCCA

>In-frame_ENST00000277541_ENST00000225893_TCGA-BQ-7053_NOTCH1_chr9_139397634_-_HNF1B_chr17_36093814_length(amino acids)=2098AA_start in transcript=76_stop in transcript=6372
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
CVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR
TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNP
LYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLG
SLNIPYKIEAVQKFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKE
EREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSG
VRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLS
GVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFP

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Fusion Gene PPI Analysis for NOTCH1-HNF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734420_4211722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-2734448_4521722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734420_4211722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-2734448_4521722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734420_4211722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-2734448_4521722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734420_4211722.33333333333332556.0DLL4
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-2734448_4521722.33333333333332556.0DLL4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNOTCH1chr9:139397633chr17:36093736ENST00000277541-27341728_17601722.33333333333332556.0PSEN1
HgeneNOTCH1chr9:139397633chr17:36093814ENST00000277541-27341728_17601722.33333333333332556.0PSEN1
HgeneNOTCH1chr9:139397634chr17:36093736ENST00000277541-27341728_17601722.33333333333332556.0PSEN1
HgeneNOTCH1chr9:139397634chr17:36093814ENST00000277541-27341728_17601722.33333333333332556.0PSEN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOTCH1-HNF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOTCH1-HNF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOTCH1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma5CGI;CTD_human
HgeneNOTCH1C3887892Aortic Valve Disease 14CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNOTCH1C4707243Familial thoracic aortic aneurysm and aortic dissection4CLINGEN;GENOMICS_ENGLAND
HgeneNOTCH1C0006142Malignant neoplasm of breast2CGI;CTD_human
HgeneNOTCH1C0149630Bicuspid aortic valve2CTD_human;ORPHANET
HgeneNOTCH1C0678222Breast Carcinoma2CGI;CTD_human
HgeneNOTCH1C1257931Mammary Neoplasms, Human2CTD_human
HgeneNOTCH1C1458155Mammary Neoplasms2CTD_human
HgeneNOTCH1C4704874Mammary Carcinoma, Human2CTD_human
HgeneNOTCH1C0000768Congenital Abnormality1CTD_human
HgeneNOTCH1C0004114Astrocytoma1CTD_human
HgeneNOTCH1C0006663Calcinosis1CTD_human
HgeneNOTCH1C0007102Malignant tumor of colon1CTD_human
HgeneNOTCH1C0007114Malignant neoplasm of skin1CTD_human
HgeneNOTCH1C0007137Squamous cell carcinoma1CGI;CTD_human
HgeneNOTCH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNOTCH1C0007873Uterine Cervical Neoplasm1CTD_human
HgeneNOTCH1C0009375Colonic Neoplasms1CTD_human
HgeneNOTCH1C0009782Connective Tissue Diseases1GENOMICS_ENGLAND
HgeneNOTCH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneNOTCH1C0017636Glioblastoma1CTD_human
HgeneNOTCH1C0018824Heart valve disease1CTD_human
HgeneNOTCH1C0019193Hepatitis, Toxic1CTD_human
HgeneNOTCH1C0023449Acute lymphocytic leukemia1GENOMICS_ENGLAND
HgeneNOTCH1C0023452Childhood Acute Lymphoblastic Leukemia1GENOMICS_ENGLAND
HgeneNOTCH1C0023492Leukemia, T-Cell1CTD_human
HgeneNOTCH1C0024299Lymphoma1CTD_human
HgeneNOTCH1C0027765nervous system disorder1CTD_human
HgeneNOTCH1C0036439Scoliosis, unspecified1CTD_human
HgeneNOTCH1C0037286Skin Neoplasms1CTD_human
HgeneNOTCH1C0038002Splenomegaly1CTD_human
HgeneNOTCH1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNOTCH1C0263628Tumoral calcinosis1CTD_human
HgeneNOTCH1C0265268Adams Oliver syndrome1ORPHANET
HgeneNOTCH1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNOTCH1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNOTCH1C0280785Diffuse Astrocytoma1CTD_human
HgeneNOTCH1C0334579Anaplastic astrocytoma1CTD_human
HgeneNOTCH1C0334580Protoplasmic astrocytoma1CTD_human
HgeneNOTCH1C0334581Gemistocytic astrocytoma1CTD_human
HgeneNOTCH1C0334582Fibrillary Astrocytoma1CTD_human
HgeneNOTCH1C0334583Pilocytic Astrocytoma1CTD_human
HgeneNOTCH1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNOTCH1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNOTCH1C0345050Congenital aneurysm of ascending aorta1GENOMICS_ENGLAND
HgeneNOTCH1C0376634Craniofacial Abnormalities1CTD_human
HgeneNOTCH1C0428791Aortic valve calcification1CTD_human;ORPHANET
HgeneNOTCH1C0521174Microcalcification1CTD_human
HgeneNOTCH1C0547065Mixed oligoastrocytoma1CTD_human
HgeneNOTCH1C0750935Cerebral Astrocytoma1CTD_human
HgeneNOTCH1C0750936Intracranial Astrocytoma1CTD_human
HgeneNOTCH1C0751606Adult Acute Lymphocytic Leukemia1GENOMICS_ENGLAND
HgeneNOTCH1C0860207Drug-Induced Liver Disease1CTD_human
HgeneNOTCH1C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNOTCH1C1260873Aortic valve disorder1ORPHANET
HgeneNOTCH1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneNOTCH1C1621958Glioblastoma Multiforme1CTD_human
HgeneNOTCH1C1704230Grade I Astrocytoma1CTD_human
HgeneNOTCH1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneNOTCH1C4014970ADAMS-OLIVER SYNDROME 51GENOMICS_ENGLAND;UNIPROT
HgeneNOTCH1C4048328cervical cancer1CTD_human
HgeneNOTCH1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneNOTCH1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneNOTCH1C4551482Adams-Oliver syndrome 11CTD_human;GENOMICS_ENGLAND
TgeneHNF1BC0431693Renal cysts and diabetes syndrome28CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneHNF1BC0011860Diabetes Mellitus, Non-Insulin-Dependent5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneHNF1BC0033578Prostatic Neoplasms2CTD_human
TgeneHNF1BC0376358Malignant neoplasm of prostate2CTD_human
TgeneHNF1BC1567426Unilateral Multicystic Dysplastic Kidney2ORPHANET
TgeneHNF1BC1567427Bilateral Multicystic Dysplastic Kidneys2ORPHANET
TgeneHNF1BC1840451MULTICYSTIC RENAL DYSPLASIA, BILATERAL2ORPHANET
TgeneHNF1BC0008370Cholestasis1GENOMICS_ENGLAND
TgeneHNF1BC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human;GENOMICS_ENGLAND
TgeneHNF1BC1833104DIABETES MELLITUS, PERMANENT NEONATAL1GENOMICS_ENGLAND
TgeneHNF1BC1835171Hypomagnesemia 2, renal1ORPHANET
TgeneHNF1BC2931456Prostate cancer, familial1ORPHANET