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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOTCH2-MACF1 (FusionGDB2 ID:59374)

Fusion Gene Summary for NOTCH2-MACF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2-MACF1
Fusion gene ID: 59374
HgeneTgene
Gene symbol

NOTCH2

MACF1

Gene ID

4853

23499

Gene namenotch receptor 2microtubule actin crosslinking factor 1
SynonymsAGS2|HJCYS|hN2ABP620|ACF7|LIS9|MACF|OFC4
Cytomap

1p12

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 2Notch homolog 2notch 2microtubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alpha
Modification date2020032920200313
UniProtAcc.

Q9UPN3

Ensembl transtripts involved in fusion geneENST00000256646, ENST00000602566, 
ENST00000493703, 		ENST00000545844, 
ENST00000567887, ENST00000372915, 
ENST00000361689, ENST00000539005, 
ENST00000317713, ENST00000564288, 
ENST00000289893, ENST00000536367, 
ENST00000484793, ENST00000602421, 
ENST00000476350, 
Fusion gene scores* DoF score26 X 22 X 14=800824 X 23 X 9=4968
# samples 3524
** MAII scorelog2(35/8008*10)=-4.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/4968*10)=-4.37155886261196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2 [Title/Abstract] AND MACF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOTCH2(120572529)-MACF1(39775242), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NOTCH2-MACF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

HgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH2

GO:0010838

positive regulation of keratinocyte proliferation

18469519

HgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH2

GO:2000249

regulation of actin cytoskeleton reorganization

18469519

TgeneMACF1

GO:0030334

regulation of cell migration

27693509

TgeneMACF1

GO:0043001

Golgi to plasma membrane protein transport

15265687

TgeneMACF1

GO:0045773

positive regulation of axon extension

22705394

TgeneMACF1

GO:0051893

regulation of focal adhesion assembly

27693509


check buttonFusion gene breakpoints across NOTCH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MACF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0YE-01ANOTCH2chr1

120572529

-MACF1chr1

39775242

+


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Fusion Gene ORF analysis for NOTCH2-MACF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000256646ENST00000545844NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000567887NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000372915NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000361689NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000539005NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000317713NOTCH2chr1

120572529

-MACF1chr1

39775242

+
In-frameENST00000256646ENST00000564288NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000256646ENST00000289893NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000256646ENST00000536367NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000256646ENST00000484793NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000256646ENST00000602421NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-3UTRENST00000256646ENST00000476350NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000545844NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000567887NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000372915NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000361689NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000539005NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000317713NOTCH2chr1

120572529

-MACF1chr1

39775242

+
Frame-shiftENST00000602566ENST00000564288NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000602566ENST00000289893NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000602566ENST00000536367NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000602566ENST00000484793NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-intronENST00000602566ENST00000602421NOTCH2chr1

120572529

-MACF1chr1

39775242

+
5CDS-3UTRENST00000602566ENST00000476350NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000545844NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000567887NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000372915NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000361689NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000539005NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000317713NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3CDSENST00000493703ENST00000564288NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-intronENST00000493703ENST00000289893NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-intronENST00000493703ENST00000536367NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-intronENST00000493703ENST00000484793NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-intronENST00000493703ENST00000602421NOTCH2chr1

120572529

-MACF1chr1

39775242

+
intron-3UTRENST00000493703ENST00000476350NOTCH2chr1

120572529

-MACF1chr1

39775242

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256646NOTCH2chr1120572529-ENST00000545844MACF1chr139775242+1518737516138634615
ENST00000256646NOTCH2chr1120572529-ENST00000567887MACF1chr139775242+2163737516202536745
ENST00000256646NOTCH2chr1120572529-ENST00000372915MACF1chr139775242+2092437516197376573
ENST00000256646NOTCH2chr1120572529-ENST00000361689MACF1chr139775242+1505737516138634615
ENST00000256646NOTCH2chr1120572529-ENST00000539005MACF1chr139775242+1479737516134734485
ENST00000256646NOTCH2chr1120572529-ENST00000317713MACF1chr139775242+1518737516138634615
ENST00000256646NOTCH2chr1120572529-ENST00000564288MACF1chr139775242+2163737516202536745

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256646ENST00000545844NOTCH2chr1120572529-MACF1chr139775242+0.0065545640.9934455
ENST00000256646ENST00000567887NOTCH2chr1120572529-MACF1chr139775242+0.0042030920.9957969
ENST00000256646ENST00000372915NOTCH2chr1120572529-MACF1chr139775242+0.0042296670.9957703
ENST00000256646ENST00000361689NOTCH2chr1120572529-MACF1chr139775242+0.006937540.99306244
ENST00000256646ENST00000539005NOTCH2chr1120572529-MACF1chr139775242+0.0064898980.99351007
ENST00000256646ENST00000317713NOTCH2chr1120572529-MACF1chr139775242+0.0066147880.99338526
ENST00000256646ENST00000564288NOTCH2chr1120572529-MACF1chr139775242+0.0042030920.9957969

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Fusion Genomic Features for NOTCH2-MACF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NOTCH2chr1120572528-MACF1chr139775241+0.0001493160.99985063
NOTCH2chr1120572528-MACF1chr139775241+0.0001493160.99985063

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOTCH2-MACF1


check button Go to

FGviewer for the breakpoints of chr1:120572529-chr1:39775242

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MACF1

Q9UPN3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647054_706505939.0Calcium binding1
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647090_710105939.0Calcium binding2
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937054_7065934.66666666666665431.0Calcium binding1
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937090_7101934.66666666666665431.0Calcium binding2
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977054_7065934.66666666666667389.0Calcium binding1
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977090_7101934.66666666666667389.0Calcium binding2
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947054_7065934.66666666666665431.0Calcium binding1
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947090_7101934.66666666666665431.0Calcium binding2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641122_112705939.0Compositional biasNote=Poly-Ser
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641414_141705939.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641986_198905939.0Compositional biasNote=Poly-Leu
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064698_70305939.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647222_735105939.0Compositional biasNote=Ser-rich
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931122_1127934.66666666666665431.0Compositional biasNote=Poly-Ser
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931414_1417934.66666666666665431.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931986_1989934.66666666666665431.0Compositional biasNote=Poly-Leu
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937222_7351934.66666666666665431.0Compositional biasNote=Ser-rich
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971122_1127934.66666666666667389.0Compositional biasNote=Poly-Ser
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971414_1417934.66666666666667389.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971986_1989934.66666666666667389.0Compositional biasNote=Poly-Leu
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977222_7351934.66666666666667389.0Compositional biasNote=Ser-rich
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941122_1127934.66666666666665431.0Compositional biasNote=Poly-Ser
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941414_1417934.66666666666665431.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941986_1989934.66666666666665431.0Compositional biasNote=Poly-Leu
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947222_7351934.66666666666665431.0Compositional biasNote=Ser-rich
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064194_29805939.0DomainCalponin-homology (CH) 2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647041_707605939.0DomainEF-hand 1
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647077_711205939.0DomainEF-hand 2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647117_718905939.0DomainGAR
TgeneMACF1chr1:120572529chr1:39775242ENST0000028989306478_18105939.0DomainCalponin-homology (CH) 1
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064868_92505939.0DomainSH3
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937041_7076934.66666666666665431.0DomainEF-hand 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937077_7112934.66666666666665431.0DomainEF-hand 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937117_7189934.66666666666665431.0DomainGAR
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977041_7076934.66666666666667389.0DomainEF-hand 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977077_7112934.66666666666667389.0DomainEF-hand 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977117_7189934.66666666666667389.0DomainGAR
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947041_7076934.66666666666665431.0DomainEF-hand 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947077_7112934.66666666666665431.0DomainEF-hand 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947117_7189934.66666666666665431.0DomainGAR
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641_29505939.0RegionNote=Actin-binding
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647117_738805939.0RegionC-terminal tail
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930647313_732805939.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937117_7388934.66666666666665431.0RegionC-terminal tail
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921937313_7328934.66666666666665431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977117_7388934.66666666666667389.0RegionC-terminal tail
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521977313_7328934.66666666666667389.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947117_7388934.66666666666665431.0RegionC-terminal tail
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422947313_7328934.66666666666665431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641050_107305939.0RepeatNote=LRR 5
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641128_115405939.0RepeatNote=LRR 6
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641187_121005939.0RepeatNote=LRR 7
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641257_128205939.0RepeatNote=LRR 8
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064148_17105939.0RepeatNote=LRR 1
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641577_162105939.0RepeatNote=Plectin 1
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641654_169605939.0RepeatNote=Plectin 2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641769_180905939.0RepeatNote=Plectin 3
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641811_184805939.0RepeatNote=Plectin 4
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930641855_188605939.0RepeatNote=Plectin 5
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642290_233205939.0RepeatNote=Plectin 6
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642367_241005939.0RepeatNote=Plectin 7
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064240_26405939.0RepeatNote=LRR 2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642411_243705939.0RepeatNote=Plectin 8
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642501_254305939.0RepeatNote=Plectin 9
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642581_261205939.0RepeatNote=Plectin 10
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930642686_273005939.0RepeatNote=Plectin 11
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643239_326205939.0RepeatNote=LRR 9
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643264_328305939.0RepeatNote=LRR 10
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643646_366905939.0RepeatNote=LRR 11
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643696_372005939.0RepeatNote=LRR 12
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064377_39905939.0RepeatNote=LRR 3
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643883_395705939.0RepeatNote=Spectrin 1
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930643936_395805939.0RepeatNote=LRR 13
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644000_410805939.0RepeatNote=Spectrin 2
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644125_415005939.0RepeatNote=LRR 14
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644261_428705939.0RepeatNote=LRR 15
TgeneMACF1chr1:120572529chr1:39775242ENST00000289893064441_46405939.0RepeatNote=LRR 4
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644466_457405939.0RepeatNote=Spectrin 3
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644511_453405939.0RepeatNote=LRR 16
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644601_462405939.0RepeatNote=LRR 17
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644769_479205939.0RepeatNote=LRR 18
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644800_490405939.0RepeatNote=Spectrin 4
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930644909_501205939.0RepeatNote=Spectrin 5
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645051_507605939.0RepeatNote=LRR 19
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645172_519405939.0RepeatNote=LRR 20
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645236_534105939.0RepeatNote=Spectrin 6
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645281_530405939.0RepeatNote=LRR 21
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645348_545005939.0RepeatNote=Spectrin 7
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645455_555705939.0RepeatNote=Spectrin 8
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645695_571905939.0RepeatNote=LRR 22
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645783_588505939.0RepeatNote=Spectrin 9
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930645804_582805939.0RepeatNote=LRR 23
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646005_611005939.0RepeatNote=Spectrin 10
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646115_621905939.0RepeatNote=Spectrin 11
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646225_632805939.0RepeatNote=Spectrin 12
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646333_643905939.0RepeatNote=Spectrin 13
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646443_654705939.0RepeatNote=Spectrin 14
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646496_651905939.0RepeatNote=LRR 24
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646552_665805939.0RepeatNote=Spectrin 15
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646665_676605939.0RepeatNote=Spectrin 16
TgeneMACF1chr1:120572529chr1:39775242ENST000002898930646771_687405939.0RepeatNote=Spectrin 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931050_1073934.66666666666665431.0RepeatNote=LRR 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931128_1154934.66666666666665431.0RepeatNote=LRR 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931187_1210934.66666666666665431.0RepeatNote=LRR 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931257_1282934.66666666666665431.0RepeatNote=LRR 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931577_1621934.66666666666665431.0RepeatNote=Plectin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931654_1696934.66666666666665431.0RepeatNote=Plectin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931769_1809934.66666666666665431.0RepeatNote=Plectin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931811_1848934.66666666666665431.0RepeatNote=Plectin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931855_1886934.66666666666665431.0RepeatNote=Plectin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932290_2332934.66666666666665431.0RepeatNote=Plectin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932367_2410934.66666666666665431.0RepeatNote=Plectin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932411_2437934.66666666666665431.0RepeatNote=Plectin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932501_2543934.66666666666665431.0RepeatNote=Plectin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932581_2612934.66666666666665431.0RepeatNote=Plectin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921932686_2730934.66666666666665431.0RepeatNote=Plectin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933239_3262934.66666666666665431.0RepeatNote=LRR 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933264_3283934.66666666666665431.0RepeatNote=LRR 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933646_3669934.66666666666665431.0RepeatNote=LRR 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933696_3720934.66666666666665431.0RepeatNote=LRR 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933883_3957934.66666666666665431.0RepeatNote=Spectrin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921933936_3958934.66666666666665431.0RepeatNote=LRR 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934000_4108934.66666666666665431.0RepeatNote=Spectrin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934125_4150934.66666666666665431.0RepeatNote=LRR 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934261_4287934.66666666666665431.0RepeatNote=LRR 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934466_4574934.66666666666665431.0RepeatNote=Spectrin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934511_4534934.66666666666665431.0RepeatNote=LRR 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934601_4624934.66666666666665431.0RepeatNote=LRR 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934769_4792934.66666666666665431.0RepeatNote=LRR 18
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934800_4904934.66666666666665431.0RepeatNote=Spectrin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921934909_5012934.66666666666665431.0RepeatNote=Spectrin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935051_5076934.66666666666665431.0RepeatNote=LRR 19
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935172_5194934.66666666666665431.0RepeatNote=LRR 20
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935236_5341934.66666666666665431.0RepeatNote=Spectrin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935281_5304934.66666666666665431.0RepeatNote=LRR 21
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935348_5450934.66666666666665431.0RepeatNote=Spectrin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935455_5557934.66666666666665431.0RepeatNote=Spectrin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935695_5719934.66666666666665431.0RepeatNote=LRR 22
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935783_5885934.66666666666665431.0RepeatNote=Spectrin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921935804_5828934.66666666666665431.0RepeatNote=LRR 23
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936005_6110934.66666666666665431.0RepeatNote=Spectrin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936115_6219934.66666666666665431.0RepeatNote=Spectrin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936225_6328934.66666666666665431.0RepeatNote=Spectrin 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936333_6439934.66666666666665431.0RepeatNote=Spectrin 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936443_6547934.66666666666665431.0RepeatNote=Spectrin 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936496_6519934.66666666666665431.0RepeatNote=LRR 24
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936552_6658934.66666666666665431.0RepeatNote=Spectrin 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936665_6766934.66666666666665431.0RepeatNote=Spectrin 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921936771_6874934.66666666666665431.0RepeatNote=Spectrin 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971050_1073934.66666666666667389.0RepeatNote=LRR 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971128_1154934.66666666666667389.0RepeatNote=LRR 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971187_1210934.66666666666667389.0RepeatNote=LRR 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971257_1282934.66666666666667389.0RepeatNote=LRR 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971577_1621934.66666666666667389.0RepeatNote=Plectin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971654_1696934.66666666666667389.0RepeatNote=Plectin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971769_1809934.66666666666667389.0RepeatNote=Plectin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971811_1848934.66666666666667389.0RepeatNote=Plectin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971855_1886934.66666666666667389.0RepeatNote=Plectin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972290_2332934.66666666666667389.0RepeatNote=Plectin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972367_2410934.66666666666667389.0RepeatNote=Plectin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972411_2437934.66666666666667389.0RepeatNote=Plectin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972501_2543934.66666666666667389.0RepeatNote=Plectin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972581_2612934.66666666666667389.0RepeatNote=Plectin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521972686_2730934.66666666666667389.0RepeatNote=Plectin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973239_3262934.66666666666667389.0RepeatNote=LRR 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973264_3283934.66666666666667389.0RepeatNote=LRR 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973646_3669934.66666666666667389.0RepeatNote=LRR 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973696_3720934.66666666666667389.0RepeatNote=LRR 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973883_3957934.66666666666667389.0RepeatNote=Spectrin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521973936_3958934.66666666666667389.0RepeatNote=LRR 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974000_4108934.66666666666667389.0RepeatNote=Spectrin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974125_4150934.66666666666667389.0RepeatNote=LRR 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974261_4287934.66666666666667389.0RepeatNote=LRR 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974466_4574934.66666666666667389.0RepeatNote=Spectrin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974511_4534934.66666666666667389.0RepeatNote=LRR 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974601_4624934.66666666666667389.0RepeatNote=LRR 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974769_4792934.66666666666667389.0RepeatNote=LRR 18
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974800_4904934.66666666666667389.0RepeatNote=Spectrin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521974909_5012934.66666666666667389.0RepeatNote=Spectrin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975051_5076934.66666666666667389.0RepeatNote=LRR 19
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975172_5194934.66666666666667389.0RepeatNote=LRR 20
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975236_5341934.66666666666667389.0RepeatNote=Spectrin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975281_5304934.66666666666667389.0RepeatNote=LRR 21
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975348_5450934.66666666666667389.0RepeatNote=Spectrin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975455_5557934.66666666666667389.0RepeatNote=Spectrin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975695_5719934.66666666666667389.0RepeatNote=LRR 22
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975783_5885934.66666666666667389.0RepeatNote=Spectrin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521975804_5828934.66666666666667389.0RepeatNote=LRR 23
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976005_6110934.66666666666667389.0RepeatNote=Spectrin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976115_6219934.66666666666667389.0RepeatNote=Spectrin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976225_6328934.66666666666667389.0RepeatNote=Spectrin 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976333_6439934.66666666666667389.0RepeatNote=Spectrin 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976443_6547934.66666666666667389.0RepeatNote=Spectrin 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976496_6519934.66666666666667389.0RepeatNote=LRR 24
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976552_6658934.66666666666667389.0RepeatNote=Spectrin 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976665_6766934.66666666666667389.0RepeatNote=Spectrin 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521976771_6874934.66666666666667389.0RepeatNote=Spectrin 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941050_1073934.66666666666665431.0RepeatNote=LRR 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941128_1154934.66666666666665431.0RepeatNote=LRR 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941187_1210934.66666666666665431.0RepeatNote=LRR 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941257_1282934.66666666666665431.0RepeatNote=LRR 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941577_1621934.66666666666665431.0RepeatNote=Plectin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941654_1696934.66666666666665431.0RepeatNote=Plectin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941769_1809934.66666666666665431.0RepeatNote=Plectin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941811_1848934.66666666666665431.0RepeatNote=Plectin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941855_1886934.66666666666665431.0RepeatNote=Plectin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942290_2332934.66666666666665431.0RepeatNote=Plectin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942367_2410934.66666666666665431.0RepeatNote=Plectin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942411_2437934.66666666666665431.0RepeatNote=Plectin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942501_2543934.66666666666665431.0RepeatNote=Plectin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942581_2612934.66666666666665431.0RepeatNote=Plectin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422942686_2730934.66666666666665431.0RepeatNote=Plectin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943239_3262934.66666666666665431.0RepeatNote=LRR 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943264_3283934.66666666666665431.0RepeatNote=LRR 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943646_3669934.66666666666665431.0RepeatNote=LRR 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943696_3720934.66666666666665431.0RepeatNote=LRR 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943883_3957934.66666666666665431.0RepeatNote=Spectrin 1
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422943936_3958934.66666666666665431.0RepeatNote=LRR 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944000_4108934.66666666666665431.0RepeatNote=Spectrin 2
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944125_4150934.66666666666665431.0RepeatNote=LRR 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944261_4287934.66666666666665431.0RepeatNote=LRR 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944466_4574934.66666666666665431.0RepeatNote=Spectrin 3
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944511_4534934.66666666666665431.0RepeatNote=LRR 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944601_4624934.66666666666665431.0RepeatNote=LRR 17
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944769_4792934.66666666666665431.0RepeatNote=LRR 18
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944800_4904934.66666666666665431.0RepeatNote=Spectrin 4
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422944909_5012934.66666666666665431.0RepeatNote=Spectrin 5
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945051_5076934.66666666666665431.0RepeatNote=LRR 19
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945172_5194934.66666666666665431.0RepeatNote=LRR 20
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945236_5341934.66666666666665431.0RepeatNote=Spectrin 6
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945281_5304934.66666666666665431.0RepeatNote=LRR 21
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945348_5450934.66666666666665431.0RepeatNote=Spectrin 7
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945455_5557934.66666666666665431.0RepeatNote=Spectrin 8
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945695_5719934.66666666666665431.0RepeatNote=LRR 22
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945783_5885934.66666666666665431.0RepeatNote=Spectrin 9
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422945804_5828934.66666666666665431.0RepeatNote=LRR 23
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946005_6110934.66666666666665431.0RepeatNote=Spectrin 10
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946115_6219934.66666666666665431.0RepeatNote=Spectrin 11
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946225_6328934.66666666666665431.0RepeatNote=Spectrin 12
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946333_6439934.66666666666665431.0RepeatNote=Spectrin 13
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946443_6547934.66666666666665431.0RepeatNote=Spectrin 14
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946496_6519934.66666666666665431.0RepeatNote=LRR 24
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946552_6658934.66666666666665431.0RepeatNote=Spectrin 15
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946665_6766934.66666666666665431.0RepeatNote=Spectrin 16
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422946771_6874934.66666666666665431.0RepeatNote=Spectrin 17

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341645_164851.6666666666666642472.0Compositional biasNote=Poly-Ala
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341994_199751.6666666666666642472.0Compositional biasNote=Poly-Leu
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2342426_242951.6666666666666642472.0Compositional biasNote=Poly-Ser
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341025_106151.6666666666666642472.0DomainEGF-like 27%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234105_14351.6666666666666642472.0DomainEGF-like 3
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341063_109951.6666666666666642472.0DomainEGF-like 28
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341101_114751.6666666666666642472.0DomainEGF-like 29
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341149_118551.6666666666666642472.0DomainEGF-like 30%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341187_122351.6666666666666642472.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341225_126251.6666666666666642472.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341264_130251.6666666666666642472.0DomainEGF-like 33
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341304_134351.6666666666666642472.0DomainEGF-like 34
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341374_141251.6666666666666642472.0DomainEGF-like 35
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234144_18051.6666666666666642472.0DomainEGF-like 4
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234182_21951.6666666666666642472.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234221_25851.6666666666666642472.0DomainEGF-like 6
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234260_29651.6666666666666642472.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-23426_6351.6666666666666642472.0DomainEGF-like 1
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234298_33651.6666666666666642472.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234338_37451.6666666666666642472.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234375_41351.6666666666666642472.0DomainEGF-like 10
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234415_45451.6666666666666642472.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234456_49251.6666666666666642472.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234494_53051.6666666666666642472.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234532_56851.6666666666666642472.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234570_60551.6666666666666642472.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234607_64351.6666666666666642472.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234645_68051.6666666666666642472.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-23464_10251.6666666666666642472.0DomainEGF-like 2
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234682_71851.6666666666666642472.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234720_75551.6666666666666642472.0DomainEGF-like 19
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234757_79351.6666666666666642472.0DomainEGF-like 20%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234795_83151.6666666666666642472.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234833_87151.6666666666666642472.0DomainEGF-like 22
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234873_90951.6666666666666642472.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234911_94751.6666666666666642472.0DomainEGF-like 24%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234949_98551.6666666666666642472.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-234987_102351.6666666666666642472.0DomainEGF-like 26%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341425_167751.6666666666666642472.0RegionNote=Negative regulatory region (NRR)
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341425_146551.6666666666666642472.0RepeatNote=LNR 1
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341466_150251.6666666666666642472.0RepeatNote=LNR 2
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341503_154451.6666666666666642472.0RepeatNote=LNR 3
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341827_187151.6666666666666642472.0RepeatNote=ANK 1
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341876_190551.6666666666666642472.0RepeatNote=ANK 2
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341909_193951.6666666666666642472.0RepeatNote=ANK 3
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341943_197251.6666666666666642472.0RepeatNote=ANK 4
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341976_200551.6666666666666642472.0RepeatNote=ANK 5
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2342009_203851.6666666666666642472.0RepeatNote=ANK 6
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341699_247151.6666666666666642472.0Topological domainCytoplasmic
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-23426_167751.6666666666666642472.0Topological domainExtracellular
HgeneNOTCH2chr1:120572529chr1:39775242ENST00000256646-2341678_169851.6666666666666642472.0TransmembraneHelical
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193698_703934.66666666666665431.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197698_703934.66666666666667389.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294698_703934.66666666666665431.0Compositional biasNote=Poly-Glu
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193194_298934.66666666666665431.0DomainCalponin-homology (CH) 2
TgeneMACF1chr1:120572529chr1:39775242ENST00000361689219378_181934.66666666666665431.0DomainCalponin-homology (CH) 1
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193868_925934.66666666666665431.0DomainSH3
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197194_298934.66666666666667389.0DomainCalponin-homology (CH) 2
TgeneMACF1chr1:120572529chr1:39775242ENST00000372915219778_181934.66666666666667389.0DomainCalponin-homology (CH) 1
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197868_925934.66666666666667389.0DomainSH3
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294194_298934.66666666666665431.0DomainCalponin-homology (CH) 2
TgeneMACF1chr1:120572529chr1:39775242ENST00000545844229478_181934.66666666666665431.0DomainCalponin-homology (CH) 1
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294868_925934.66666666666665431.0DomainSH3
TgeneMACF1chr1:120572529chr1:39775242ENST0000036168921931_295934.66666666666665431.0RegionNote=Actin-binding
TgeneMACF1chr1:120572529chr1:39775242ENST0000037291521971_295934.66666666666667389.0RegionNote=Actin-binding
TgeneMACF1chr1:120572529chr1:39775242ENST0000054584422941_295934.66666666666665431.0RegionNote=Actin-binding
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193148_171934.66666666666665431.0RepeatNote=LRR 1
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193240_264934.66666666666665431.0RepeatNote=LRR 2
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193377_399934.66666666666665431.0RepeatNote=LRR 3
TgeneMACF1chr1:120572529chr1:39775242ENST000003616892193441_464934.66666666666665431.0RepeatNote=LRR 4
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197148_171934.66666666666667389.0RepeatNote=LRR 1
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197240_264934.66666666666667389.0RepeatNote=LRR 2
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197377_399934.66666666666667389.0RepeatNote=LRR 3
TgeneMACF1chr1:120572529chr1:39775242ENST000003729152197441_464934.66666666666667389.0RepeatNote=LRR 4
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294148_171934.66666666666665431.0RepeatNote=LRR 1
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294240_264934.66666666666665431.0RepeatNote=LRR 2
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294377_399934.66666666666665431.0RepeatNote=LRR 3
TgeneMACF1chr1:120572529chr1:39775242ENST000005458442294441_464934.66666666666665431.0RepeatNote=LRR 4


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Fusion Gene Sequence for NOTCH2-MACF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000256646_ENST00000545844_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=15187nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTG
CAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAG
TGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAA
TCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGAC
ACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGA
GAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGA
GCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAA
GCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTT
GGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCT
GGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTG
GTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAG
CTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAA
GGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTG
TACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGC
TTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTT
GCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCC
AGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCT
GCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGG
GAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAG
CAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGA
GGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGA
ACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTT
CTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTC
TTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGA
GAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGA
AGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGC
AAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGG
CAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTG
TGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAAT
GGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCC
AACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGT
AAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCG
ATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATC
CCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAA
GCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGG
CCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAA
CTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGT
TGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGA
CTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGA
ACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCT
TGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAAT
TTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGT
GATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAA
CCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGT
GGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCT
CCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTC
TTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAAC
AGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCA
ACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCT
AGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCA
AGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGG
CCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACAC
TGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGA
GTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACT
GACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGA
CGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAA
AATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAA
AGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGC
ACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCAT
AGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCG
AAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCT
GGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACA
GTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGC
CAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGG
GCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCA
AGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTG
GCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGC
TTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGA
GGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGA
GCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAG
TGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGT
GTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGC
TAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCA
AGCTGCCGATGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCAC
AGCTCAGCTTCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAAT
CTTTGGCACATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAA
TTCAGAGCGTTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGA
AACTCGGGCACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGA
ATCTATTGCTGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGT
GGAAGAAAAATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTC
CCAGTCCACACAGATTACAGAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACC
ACTGATCCCTGCTGAAGTAGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTT
TGAGGCCTTGAAGCGCCGTGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATT
GGATCAAATGGTATTCTTCTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAA
GTTCTGGTATGACATGGCAGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTC
CATCATCAAACAACAGGTTGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGG
AGCAGATTTGATTTTTGCCTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAA
CAAAACATGGAAAGAGAGGCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTG
GCTAGATAACACTGTGATTAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGA
GTTCAAAGTAGAAGTTTACCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGAC
GGACAGAGACATTATACGAGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACT
AGAAGGGGCTCTGTTGGCCCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGC
TCAGAGACCAATAAGTGGAGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGC
CACAGTGGAAACAGTCAACAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGC
CATGAACCAATGCTGGGAGTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCA
CAGTGAAATTGAAGATTTCCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGC
TAGGGAACAGCTTGATACACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACT
CATGCTTCTAAGCCGTGACGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAG
TAAGATGGAAGAAAGAAAGTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCT
CACTCTAGCAGAGCAGAGTTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTT
TGCTAATGAAGTAAATGCTCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGT
TGTTCTGATCAAGAATTTGTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGA
TGCCAGGAAGCGGGCAAAACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACT
AGAGATATCCAATGACCCAGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTA
TGATACCACAATTAGAACTGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGT
CAGAGACAAATGGGATACTGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGA
TGCTTTGCAGGCATTGGTTGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCAT
GAACCTCATGGATGCACACAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCT
GATTGAGAATAGTCGAGATGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGT
TTCCAAACAAAGCCGGCTTGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGC
AGAGCAAACGCTTCGCTTTCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAA
AGTAGAAGAAAAGCGAGTGGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCAT
CAAACACTGGATCACCATCATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTC
AGAACTGGTGGCTAATGCTGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCC
AATCCCGCAGAACATTGACCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGA
CCGGGTCACCAAGACATACAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCT
AAGTCAGCCAACCCCTCCTCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCA
GGTGTGGCTGTTAGCACTGGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTT
TGATGTCTGGAGGAAAAAGTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGA
TGGGAAGATAACACGTCAGGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACAT
TTTCGACCGAGATGGGGATGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGA
TGCAGATAAAATCGAAGATGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAA
ATACCGGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTT
GGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGC
ATCCCAGGGAATGACCCCCTTCCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGC
TAGTCAGAGTAACCACAGCTGTACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGGTTATCCCATCATCAGGTAGCAA
GTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGC
CAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCG
AGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAA
CTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCG
ATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTA
TATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTAT
GTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACA
AATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAA
ATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTT
TTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAG
GGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTT
TAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTC
CCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTC
AGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTG
AAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTT
TTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACC
ATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTG
TATTAAAATTGCTTGCAGTAACAAATATTTTGTATTTCCTGATTTTCTTTTCAACTATTACCTTATCTATAAATGTTACCCTGGGGTATA

>In-frame_ENST00000256646_ENST00000545844_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=4615AA_start in transcript=16_stop in transcript=13863
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS
PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA
SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA
ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP
SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA
EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK
LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA
SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI
LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET
VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW
LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ
IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL
ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG
ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA
MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD
ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR
VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK
ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ
GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD
MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ
IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE
DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL
ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK
LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG
EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH
KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE
VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM
AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE
RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII
REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV
NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD
THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ
SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA
KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD
TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR
DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR
VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI
DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA
LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG
DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV
KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT
PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000567887_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=21637nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATT
TCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCAT
TGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCT
ACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGA
GACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGC
TTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGC
TGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGG
GGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTT
GCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGAT
TGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGA
TGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGA
ATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCA
TATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAA
TAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGT
TCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGT
GCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGT
GGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTG
GACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGAC
CACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTT
GAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAA
TGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAAC
ACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGA
TGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTC
TGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGA
AGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCA
TCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAA
GCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTT
CTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCAT
GGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAA
GGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGC
CTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGT
TAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGA
CAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAG
ACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCA
GATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCA
GGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAAC
TAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAA
ATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTAC
ATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGA
TACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCA
GGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACT
GGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACA
AAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATT
TCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAA
GGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGG
TAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGA
TACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAAT
AAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCA
ACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTC
TGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAA
AGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGT
AAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACC
AGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCA
GGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAA
CTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGA
AGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTC
AGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAAC
TGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAG
AGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTAC
TGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGA
AAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCA
GAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAA
ACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGAC
CACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGA
GAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAAT
AGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCT
GAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGA
AAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACA
GATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCT
TCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGT
AGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAA
GGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAA
GCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGC
CCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAA
GAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTC
GGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGA
GATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCA
TGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATC
AGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACG
ATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGA
GGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAA
AGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATT
AGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGC
CAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGA
ATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAG
GCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGC
AATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGT
GTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGA
GGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCA
GCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTC
TGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACA
GATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTT
TGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAA
AGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTAT
TCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGG
AACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGG
TTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTC
AGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGT
TCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGAC
AGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGC
CCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAG
GGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCG
GCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGT
CCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGA
TGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTC
CAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACG
GCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCA
GTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAA
GCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCAC
CCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAA
ATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGC
TGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGA
AGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCT
TGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATC
AAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGC
AGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACT
CGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGAT
CTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCA
GGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGT
CGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCA
CTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCT
CCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACA
TATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAG
GGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCAC
AGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCA
GAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGA
TGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACA
GGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCA
GAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCAC
AGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCT
TGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGA
GACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACA
GCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCT
CTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTG
TTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGA
GGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGA
AGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACT
TATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCG
GCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACA
GTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACAC
AGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCA
GTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCAAGCTGCCGA
TGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCACAGCTCAGCT
TCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAATCTTTGGCAC
ATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAATTCAGAGCG
TTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGAAACTCGGGC
ACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGAATCTATTGC
TGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGTGGAAGAAAA
ATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTCCCAGTCCAC
ACAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACCACTGATCCCTGCTGAAGT
AGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTTTGAGGCCTTGAAGCGCCG
TGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATTGGATCAAATGGTATTCTT
CTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAAGTTCTGGTATGACATGGC
AGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTCCATCATCAAACAACAGGT
TGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGGAGCAGATTTGATTTTTGC
CTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAACAAAACATGGAAAGAGAG
GCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTGGCTAGATAACACTGTGAT
TAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGAGTTCAAAGTAGAAGTTTA
CCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGACGGACAGAGACATTATACG
AGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACTAGAAGGGGCTCTGTTGGC
CCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGCTCAGAGACCAATAAGTGG
AGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGCCACAGTGGAAACAGTCAA
CAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGCCATGAACCAATGCTGGGA
GTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCACAGTGAAATTGAAGATTT
CCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGCTAGGGAACAGCTTGATAC
ACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACTCATGCTTCTAAGCCGTGA
CGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAGTAAGATGGAAGAAAGAAA
GTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCTCACTCTAGCAGAGCAGAG
TTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTTTGCTAATGAAGTAAATGC
TCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGTTGTTCTGATCAAGAATTT
GTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGATGCCAGGAAGCGGGCAAA
ACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACTAGAGATATCCAATGACCC
AGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTATGATACCACAATTAGAAC
TGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGTCAGAGACAAATGGGATAC
TGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGATGCTTTGCAGGCATTGGT
TGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCATGAACCTCATGGATGCACA
CAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCTGATTGAGAATAGTCGAGA
TGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGTTTCCAAACAAAGCCGGCT
TGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGCAGAGCAAACGCTTCGCTT
TCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAAAGTAGAAGAAAAGCGAGT
GGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCATCAAACACTGGATCACCAT
CATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTCAGAACTGGTGGCTAATGC
TGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCCAATCCCGCAGAACATTGA
CCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGACCGGGTCACCAAGACATA
CAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCTAAGTCAGCCAACCCCTCC
TCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCAGGTGTGGCTGTTAGCACT
GGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTTTGATGTCTGGAGGAAAAA
GTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGATGGGAAGATAACACGTCA
GGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACATTTTCGACCGAGATGGGGA
TGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGATGCAGATAAAATCGAAGA
TGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAAATACCGGTTCTTCCTCGG
CAATCAGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTT
GGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGTTCACCATCCTGGGAGTAAAATAAAGCGCTCTGATTCCAGCTCTTCGATTTCCAG
TCAGTCTCCCATAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGCATCCCAGGGAATGACCCCCTT
CCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGCTAGTCAGAGTAACCACAGCTG
TACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGACTTCACTTCAGTTCTCTCGCTGTTATGACAAACCCTGGTTGGT
AAACAGTAAAGCTGGCACCCCTATCAGGGACAGCCATTCTCCTGACCTCCAGCTGCCCACCCCCGAGGTTATCCCATCATCAGGTAGCAA
GTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGC
CAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCG
AGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAA
CTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCG
ATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTA
TATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTAT
GTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACA
AATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAA
ATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTT
TTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAG
GGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTT
TAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTC
CCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTC
AGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTG
AAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTT
TTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACC
ATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTG
TATTAAAATTGCTTGCAGTAACAAATATTTTGTATTTCCTGATTTTCTTTTCAACTATTACCTTATCTATAAATGTTACCCTGGGGTATA
ATCATGTTGTAGGTACTTAAATGCATTCCGCAAATCAAAATATCTTGATGGATAAATTATAGAGCTTAATAGATCTTGTTTTATTTCATC

>In-frame_ENST00000256646_ENST00000567887_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=6745AA_start in transcript=16_stop in transcript=20253
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA
LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL
LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA
CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF
LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR
LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE
DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH
QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA
GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT
CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL
VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN
AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL
SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK
RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG
KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ
VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR
VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA
LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW
VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL
EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE
QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ
ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS
NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ
EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE
LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE
KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK
QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ
VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS
GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ
FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC
QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS
VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA
QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME
KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ
AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV
ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL
LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN
EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG
SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE
MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ
EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE
HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ
AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR
HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL
SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK
FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS
DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ
KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH
IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE
CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT
IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE
DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE
LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNE
LLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY
SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIAS
PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA
WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKS
VERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV
KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA
VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKAL
IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK
LNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY
YEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV
KNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPS
SPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRA

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000372915_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=20924nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATT
TCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCAT
TGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCT
ACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGA
GACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGC
TTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGC
TGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGG
GGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTT
GCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGAT
TGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGA
TGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGA
ATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCA
TATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAA
TAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGT
TCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGT
GCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGT
GGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTG
GACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGAC
CACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTT
GAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAA
TGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAAC
ACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGA
TGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTC
TGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGA
AGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCA
TCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAA
GCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTT
CTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCAT
GGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAA
GGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGC
CTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGT
TAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGA
CAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAG
ACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCA
GATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCA
GGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAAC
TAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAA
ATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTAC
ATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGA
TACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCA
GGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACT
GGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACA
AAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATT
TCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAA
GGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGG
TAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGA
TACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAAT
AAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCA
ACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTC
TGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAA
AGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGT
AAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACC
AGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCA
GGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAA
CTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGA
AGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTC
AGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAAC
TGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAG
AGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTAC
TGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGA
AAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCA
GAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAA
ACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGAC
CACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGA
GAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAAT
AGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCT
GAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGA
AAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACA
GATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCT
TCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGT
AGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAA
GGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAA
GCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGC
CCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAA
GAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTC
GGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGA
GATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCA
TGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATC
AGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACG
ATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGA
GGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAA
AGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATT
AGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGC
CAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGA
ATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAG
GCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGC
AATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGT
GTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGA
GGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCA
GCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTC
TGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACA
GATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTT
TGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAA
AGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTAT
TCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGG
AACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGG
TTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTC
AGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGT
TCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGAC
AGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGC
CCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAG
GGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCG
GCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGT
CCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGA
TGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTC
CAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACG
GCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCA
GTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAA
GCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCAC
CCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAA
ATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGC
TGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGA
AGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCT
TGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATC
AAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGC
AGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACT
CGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGAT
CTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCA
GGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGT
CGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCA
CTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCT
CCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACA
TATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAG
GGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCAC
AGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCA
GAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGA
TGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACA
GGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCA
GAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCAC
AGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCT
TGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGA
GACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACA
GCAGCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCT
TCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAG
CTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGA
GGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAA
GGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGG
GCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTAT
TCAGAGATCACAACAGTATGAGCAAGCTGCCGATGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAAT
TCGCCTGGAACAGGACCAGACCACAGCTCAGCTTCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGA
ACTCTTCAGTCACCGTAGTGAAATCTTTGGCACATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCA
ATATGAAGCCATTAGCCTACTCAATTCAGAGCGTTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGA
AGAGCTCAGCCCCTGGATTGAGGAAACTCGGGCACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACA
AGAGGAAATGAGGCAATTAAGGGAATCTATTGCTGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATT
AAACCCTGAGGAAGGGGAAATGGTGGAAGAAAAATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGC
CCTGGCTCTGGATGAAGCCGTGTCCCAGTCCACACAGATTACAGAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCT
TTCCTCTCGCCTGCGTATGCCACCACTGATCCCTGCTGAAGTAGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGA
GCTAGAAAAACTGCAGCCATCCTTTGAGGCCTTGAAGCGCCGTGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGC
TGCAAAAGAAATCCAGGATAAATTGGATCAAATGGTATTCTTCTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCT
TGATGTCCTTGAATTAGCAGAGAAGTTCTGGTATGACATGGCAGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTT
GGAAAGCCCAGGCATTGATCCTTCCATCATCAAACAACAGGTTGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGA
GCTGGAGTTTATTCGGATCCTTGGAGCAGATTTGATTTTTGCCTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGAT
GAATAATGCTTGGGAGAACTTAAACAAAACATGGAAAGAGAGGCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGA
CACTCTTCAGGCTATGTTTGACTGGCTAGATAACACTGTGATTAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAA
AGATCAGTTAAATGAAATGAAGGAGTTCAAAGTAGAAGTTTACCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGAT
GTTAAAGAAAGCTACTGATGAGACGGACAGAGACATTATACGAGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAA
AATTGCCCACCGACAGCACAAACTAGAAGGGGCTCTGTTGGCCCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGAC
TCATACCGAAGAGTTGTTAGATGCTCAGAGACCAATAAGTGGAGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAA
AAATGATGTTTTGGCTCATCAAGCCACAGTGGAAACAGTCAACAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAG
CAGCTTAAGGAGCCGTTTGGAAGCCATGAACCAATGCTGGGAGTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAAC
TCTGCAGCAGGCCCAGGGCTTCCACAGTGAAATTGAAGATTTCCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCC
CACAGGAGGACTTCCTGAAACTGCTAGGGAACAGCTTGATACACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAA
TCAACTACTTGACAAGGGCAGACTCATGCTTCTAAGCCGTGACGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGA
GCAGAAGTGGCATGTGGTCAGCAGTAAGATGGAAGAAAGAAAGTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTC
CCTACAAGAATTTATCAACTGGCTCACTCTAGCAGAGCAGAGTTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTC
CCAGATAGAAGAGCACAAGGTTTTTGCTAATGAAGTAAATGCTCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAA
GTTCCTTAGCCAAAAGCAGGATGTTGTTCTGATCAAGAATTTGTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTAT
TGAAAGAGGGCGATCACTAGATGATGCCAGGAAGCGGGCAAAACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGC
AGAGAGTCACCTGGACTCAGAACTAGAGATATCCAATGACCCAGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGAC
TCTTGGTGGCAAGCAGCCTGTGTATGATACCACAATTAGAACTGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAA
ACTTGACAATTTCCTAGGAGAAGTCAGAGACAAATGGGATACTGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCT
GCTCTTTTCGGGTCAGTTCATGGATGCTTTGCAGGCATTGGTTGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGT
GCACGGGGACCTTGACCTCGTCATGAACCTCATGGATGCACACAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGT
CCTGAAGCGGTCAGGCCGAGAGCTGATTGAGAATAGTCGAGATGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTG
GGACACTGTCTGTAAACTCTCTGTTTCCAAACAAAGCCGGCTTGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACAT
GCTGTTGGAGTGGCTTTCTGAAGCAGAGCAAACGCTTCGCTTTCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGA
CACCCATAAGGAATTCATGAAGAAAGTAGAAGAAAAGCGAGTGGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTG
CCACCCCGATTGCATCACAACCATCAAACACTGGATCACCATCATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCA
GCAGCGTCTTGAAACGGCCTTGTCAGAACTGGTGGCTAATGCTGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCAC
CCTCATTCAGCGGGATCAGGAGCCAATCCCGCAGAACATTGACCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGAT
GACTCGCAAACAGCCTGACGTGGACCGGGTCACCAAGACATACAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATC
CCGCAGCGGAGGCAGGAAATCCCTAAGTCAGCCAACCCCTCCTCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAA
CCAGCTTTCTGCCCGCTGGCAGCAGGTGTGGCTGTTAGCACTGGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTT
GAAAGAATTTGCCAACTTTGACTTTGATGTCTGGAGGAAAAAGTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTT
CCGGCGCATTGATAAGGACCAGGATGGGAAGATAACACGTCAGGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTT
AGAGATGACTGCTGTGGCTGACATTTTCGACCGAGATGGGGATGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAA
GGATGCGTATCGACCAACAACCGATGCAGATAAAATCGAAGATGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCA
GGTGGAGCAGATCGGAGAGAATAAATACCGGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCG
CGTTGGTGGAGGATGGATGGCCTTGGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGCACGAGGTAGAACTAACATTGAACTTAGAGA
GAAATTCATCCTACCAGAGGGAGCATCCCAGGGAATGACCCCCTTCCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTC
CCCTACTCGTTCCAGCTCCAGTGCTAGTCAGAGTAACCACAGCTGTACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAA
GGTTATCCCATCATCAGGTAGCAAGTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAG
TTCTTCCCCGGCCTCCACAGGTGCCAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGC
CGGGAGTCGAGCCAGCAGCCGGCGAGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAG
CAGCGCTGCAGGGGGCCAAGGCAACTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTC
CCCCAGGACTCCAGGTCCCAAGCGATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTAT
ATTTATTCTGAACGGGAGAAGTTATATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGT
TACTATTTTCATGTGAATATTTATGTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAA
AACAAGTGAAAAGGTCAAGATACAAATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGC
TTTATCTTTTAGGATTATTCCTAAATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAAT
CCTGCAGTGTTTAAGGAACTCTTTTTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGT
TTTGTGATTTTTAGCTAAAGAGAGGGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTG
GATATTGTTTCAGTACTGGGTGTTTAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTG
GGGTTTTAAACTGATTTGTTGCTCCCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGG
CTCGTTGGTGACATTGTGAATTTCAGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGG
AATGAATTCCACGAGCCTGTTCTGAAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACC
AGTCCTGTTTGCTTTCGTCTTTTTTTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTT
AGCTGCTGTTCTTCAGCTCCGACCATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACT

>In-frame_ENST00000256646_ENST00000372915_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=6573AA_start in transcript=16_stop in transcript=19737
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA
LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL
LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA
CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF
LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR
LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE
DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH
QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA
GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT
CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL
VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN
AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL
SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK
RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG
KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ
VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR
VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA
LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW
VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL
EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE
QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ
ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS
NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ
EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE
LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE
KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK
QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ
VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS
GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ
FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC
QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS
VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA
QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME
KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ
AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV
ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL
LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN
EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG
SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE
MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ
EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE
HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ
AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR
HKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL
ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ
YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS
LLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG
EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQ
PSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI
DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAM
FDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ
HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSR
LEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK
GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH
KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD
SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ
FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK
LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI
TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP
DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN
FDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRP
TTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILP
EGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPAS
TGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPG

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000361689_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=15057nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTG
CAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAG
TGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAA
TCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGAC
ACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGA
GAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGA
GCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAA
GCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTT
GGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCT
GGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTG
GTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAG
CTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAA
GGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTG
TACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGC
TTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTT
GCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCC
AGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCT
GCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGG
GAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAG
CAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGA
GGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGA
ACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTT
CTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTC
TTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGA
GAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGA
AGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGC
AAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGG
CAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTG
TGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAAT
GGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCC
AACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGT
AAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCG
ATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATC
CCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAA
GCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGG
CCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAA
CTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGT
TGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGA
CTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGA
ACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCT
TGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAAT
TTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGT
GATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAA
CCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGT
GGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCT
CCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTC
TTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAAC
AGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCA
ACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCT
AGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCA
AGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGG
CCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACAC
TGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGA
GTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACT
GACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGA
CGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAA
AATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAA
AGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGC
ACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCAT
AGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCG
AAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCT
GGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACA
GTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGC
CAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGG
GCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCA
AGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTG
GCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGC
TTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGA
GGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGA
GCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAG
TGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGT
GTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGC
TAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCA
AGCTGCCGATGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCAC
AGCTCAGCTTCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAAT
CTTTGGCACATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAA
TTCAGAGCGTTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGA
AACTCGGGCACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGA
ATCTATTGCTGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGT
GGAAGAAAAATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTC
CCAGTCCACACAGATTACAGAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACC
ACTGATCCCTGCTGAAGTAGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTT
TGAGGCCTTGAAGCGCCGTGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATT
GGATCAAATGGTATTCTTCTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAA
GTTCTGGTATGACATGGCAGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTC
CATCATCAAACAACAGGTTGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGG
AGCAGATTTGATTTTTGCCTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAA
CAAAACATGGAAAGAGAGGCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTG
GCTAGATAACACTGTGATTAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGA
GTTCAAAGTAGAAGTTTACCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGAC
GGACAGAGACATTATACGAGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACT
AGAAGGGGCTCTGTTGGCCCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGC
TCAGAGACCAATAAGTGGAGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGC
CACAGTGGAAACAGTCAACAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGC
CATGAACCAATGCTGGGAGTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCA
CAGTGAAATTGAAGATTTCCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGC
TAGGGAACAGCTTGATACACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACT
CATGCTTCTAAGCCGTGACGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAG
TAAGATGGAAGAAAGAAAGTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCT
CACTCTAGCAGAGCAGAGTTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTT
TGCTAATGAAGTAAATGCTCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGT
TGTTCTGATCAAGAATTTGTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGA
TGCCAGGAAGCGGGCAAAACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACT
AGAGATATCCAATGACCCAGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTA
TGATACCACAATTAGAACTGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGT
CAGAGACAAATGGGATACTGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGA
TGCTTTGCAGGCATTGGTTGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCAT
GAACCTCATGGATGCACACAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCT
GATTGAGAATAGTCGAGATGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGT
TTCCAAACAAAGCCGGCTTGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGC
AGAGCAAACGCTTCGCTTTCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAA
AGTAGAAGAAAAGCGAGTGGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCAT
CAAACACTGGATCACCATCATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTC
AGAACTGGTGGCTAATGCTGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCC
AATCCCGCAGAACATTGACCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGA
CCGGGTCACCAAGACATACAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCT
AAGTCAGCCAACCCCTCCTCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCA
GGTGTGGCTGTTAGCACTGGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTT
TGATGTCTGGAGGAAAAAGTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGA
TGGGAAGATAACACGTCAGGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACAT
TTTCGACCGAGATGGGGATGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGA
TGCAGATAAAATCGAAGATGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAA
ATACCGGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTT
GGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGC
ATCCCAGGGAATGACCCCCTTCCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGC
TAGTCAGAGTAACCACAGCTGTACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGGTTATCCCATCATCAGGTAGCAA
GTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGC
CAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCG
AGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAA
CTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCG
ATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTA
TATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTAT
GTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACA
AATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAA
ATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTT
TTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAG
GGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTT
TAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTC
CCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTC
AGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTG
AAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTT
TTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACC
ATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTG

>In-frame_ENST00000256646_ENST00000361689_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=4615AA_start in transcript=16_stop in transcript=13863
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS
PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA
SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA
ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP
SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA
EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK
LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA
SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI
LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET
VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW
LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ
IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL
ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG
ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA
MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD
ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR
VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK
ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ
GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD
MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ
IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE
DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL
ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK
LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG
EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH
KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE
VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM
AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE
RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII
REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV
NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD
THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ
SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA
KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD
TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR
DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR
VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI
DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA
LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG
DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV
KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT
PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000539005_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=14797nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTG
CAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAG
TGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAA
TCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGAC
ACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGA
GAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGA
GCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAA
GCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTT
GGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCT
GGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTG
GTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAG
CTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAA
GGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTG
TACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGC
TTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTT
GCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCC
AGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCT
GCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGG
GAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAG
CAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGA
GGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGA
ACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTT
CTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTC
TTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGA
GAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGA
AGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGC
AAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGG
CAAGACAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGA
AAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCT
GAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGA
ACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAA
GAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCA
TCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTAT
TGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAA
TGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAA
ATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCA
GGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATT
GGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCT
CATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGA
TCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACA
AAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCT
TAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCT
ACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCA
GAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCT
GGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAA
TAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGC
TGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGA
AAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAG
AGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGG
ATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGAT
GATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGA
TGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAA
ATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGA
AGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTT
CTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAAT
CATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGG
CCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATT
GAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAG
CTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAA
GTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGC
TGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCT
GGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAA
CTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAA
GAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGG
TATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCA
GTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGAT
ACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGC
TCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACAC
TATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCAAGCTGCCGATGCAGAACTAGCTTGGGTTGC
TGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCACAGCTCAGCTTCAGGTACAGAAGGCTTTCTC
CATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAATCTTTGGCACATGTGGGGAGGAGCAAAAAAC
TGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAATTCAGAGCGTTATGCCCGCCTAGAGCGGGC
CCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGAAACTCGGGCACTAATAGCACAGTTACCCTC
TCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGAATCTATTGCTGAACACAAACCTCATATTGA
CAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGTGGAAGAAAAATACCAGAAAGCAGAAAACAT
GTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTCCCAGTCCACACAGGTATCACAGTTTCATGA
TAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACCACTGATCCCTGCTGAAGTAGACAAGATCAG
AGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTTTGAGGCCTTGAAGCGCCGTGGAGAGGAGCT
TATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATTGGATCAAATGGTATTCTTCTGGGAGGACAT
CAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAAGTTCTGGTATGACATGGCAGCTCTCCTGAC
CACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTCCATCATCAAACAACAGGTTGAAGCTGCTGA
GACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGGAGCAGATTTGATTTTTGCCTGTGGAGAAAC
TGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAACAAAACATGGAAAGAGAGGCTAGAAAAACT
TGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTGGCTAGATAACACTGTGATTAAACTCTGCAC
CATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGAGTTCAAAGTAGAAGTTTACCAACAGCAAAT
TGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGACGGACAGAGACATTATACGAGAACCACTGAC
AGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACTAGAAGGGGCTCTGTTGGCCCTTGGTCAGTT
CCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGCTCAGAGACCAATAAGTGGAGACCCAAAAGT
CATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGCCACAGTGGAAACAGTCAACAAAGCTGGCAA
TGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGCCATGAACCAATGCTGGGAGTCAGTGTTACA
GAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCACAGTGAAATTGAAGATTTCCTCTTGGAACT
TACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGCTAGGGAACAGCTTGATACACATATGGAACT
CTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACTCATGCTTCTAAGCCGTGACGACTCTGGGTC
TGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAGTAAGATGGAAGAAAGAAAGTCAAAGCTGGA
AGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCTCACTCTAGCAGAGCAGAGTTTAAACATCGC
TTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTTTGCTAATGAAGTAAATGCTCATCGAGACCA
GATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGTTGTTCTGATCAAGAATTTGTTGGTGAGCGT
GCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGATGCCAGGAAGCGGGCAAAACAATTCCATGA
AGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACTAGAGATATCCAATGACCCAGACAAAATTAA
ACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTATGATACCACAATTAGAACTGGCAGAGCACT
GAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGTCAGAGACAAATGGGATACTGTTTGTGGCAA
GTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGATGCTTTGCAGGCATTGGTTGACTGGTTATA
CAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCATGAACCTCATGGATGCACACAAGGTTTTCCA
GAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCTGATTGAGAATAGTCGAGATGACACCACTTG
GGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGTTTCCAAACAAAGCCGGCTTGAGCAGGCCTT
AAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGCAGAGCAAACGCTTCGCTTTCGGGGAGCACT
TCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAAAGTAGAAGAAAAGCGAGTGGACGTTAACTC
AGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCATCAAACACTGGATCACCATCATCCGAGCTCG
CTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTCAGAACTGGTGGCTAATGCTGAGCTCCTGGA
AGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCCAATCCCGCAGAACATTGACCGAGTTAAAGC
CCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGACCGGGTCACCAAGACATACAAAAGGAAAAA
CATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCTAAGTCAGCCAACCCCTCCTCCCATGCCAAT
CCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCAGGTGTGGCTGTTAGCACTGGAGCGGCAAAG
GAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTTTGATGTCTGGAGGAAAAAGTATATGCGTTG
GATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGATGGGAAGATAACACGTCAGGAGTTTATCGA
TGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACATTTTCGACCGAGATGGGGATGGTTACATTGA
TTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGATGCAGATAAAATCGAAGATGAGGTTACAAG
ACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAAATACCGGTTTGGGGATTCTCAGCAGTTGCG
GCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTTGGATGAATTTTTAGTGAAAAATGATCCCTG
CCGAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGCATCCCAGGGAATGACCCCCTTCCGCTCACG
GGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGCTAGTCAGAGTAACCACAGCTGTACATCCAT
GCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGGTTATCCCATCATCAGGTAGCAAGTTGAAACGACCAACACCAACTTTTCATTC
TAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGCCAAAACTAATCGGGCAGACCCTAAAAAGTC
TGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCGAGGAAGTGACGCTTCTGACTTTGACCTCTT
AGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAACTCCAGGAGAGGGCTAAACAAACCTTCCAA
AATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCGATAACACTGTCTAAGCACCCCCAAGCCACT
ATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTATATTGTTAAAAGTGTAAAAGAATAATTGTG
TTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTATGTAGATAAAATTTGCCTCCTGGTAACCCTG
TAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACAAATGTGTATTAAAAAAAAAAAAGCCTATTA
ATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAAATGCATCTTCTTTATAAACTTGACTTGCTA
TCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTTTTTTGTAAATCACGGACACCTCAATTAGCA
AGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAGGGAACCTCATCTAAGTAACATTTGCACATG
ATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTTTAAAGGACAAATAGCTGCTAGAATTCAGGG
GTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTCCCTATCCAGCCTAGACACCAGTAACTCTTG
TGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTCAGATTTGTTTTATCCACTTTTTTTGCTATT
TATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTGAAAATGTGGACGTAAGACAAACACGTGCTC
GTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTTTTGTGCGTAATAAAGTCAACTGACCAAGTG
ACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACCATGTTGCTGTGTGATTATCTCAATTGGTTT
TAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTGTATTAAAATTGCTTGCAGTAACAAATATTT
TGTATTTCCTGATTTTCTTTTCAACTATTACCTTATCTATAAATGTTACCCTGGGGTATAATCATGTTGTAGGTACTTAAATGCATTCCG

>In-frame_ENST00000256646_ENST00000539005_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=4485AA_start in transcript=16_stop in transcript=13473
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS
PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA
SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA
ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP
SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA
EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK
LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA
SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTDLT
EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK
IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNML
NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK
VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL
QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV
ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI
LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV
LQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAI
GRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK
GLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVA
QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI
TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKKNVDQA
IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQ
RQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK
LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN
QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK
EEVRQRALALDEAVSQSTQVSQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ
GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE
TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG
TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE
ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEER
EQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE
QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD
QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK
HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ
LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV
FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVL
TWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTH
APFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKK
SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQC
KCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSK
PSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPG

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000317713_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=15187nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTG
CAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAG
TGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAA
TCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGAC
ACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGA
GAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGA
GCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAA
GCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTT
GGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCT
GGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTG
GTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAG
CTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAA
GGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTG
TACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGC
TTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTT
GCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCC
AGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCT
GCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGG
GAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAG
CAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGA
GGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGA
ACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTT
CTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTC
TTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGA
GAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGA
AGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGC
AAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGG
CAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTG
TGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAAT
GGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCC
AACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGT
AAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCG
ATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATC
CCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAA
GCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGG
CCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAA
CTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGT
TGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGA
CTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGA
ACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCT
TGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAAT
TTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGT
GATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAA
CCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGT
GGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCT
CCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTC
TTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAAC
AGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCA
ACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCT
AGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCA
AGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGG
CCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACAC
TGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGA
GTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACT
GACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGA
CGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAA
AATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAA
AGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGC
ACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCAT
AGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCG
AAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCT
GGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACA
GTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGC
CAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGG
GCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCA
AGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTG
GCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGC
TTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGA
GGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGA
GCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAG
TGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGT
GTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGC
TAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCA
AGCTGCCGATGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCAC
AGCTCAGCTTCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAAT
CTTTGGCACATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAA
TTCAGAGCGTTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGA
AACTCGGGCACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGA
ATCTATTGCTGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGT
GGAAGAAAAATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTC
CCAGTCCACACAGGTATCACAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACC
ACTGATCCCTGCTGAAGTAGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTT
TGAGGCCTTGAAGCGCCGTGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATT
GGATCAAATGGTATTCTTCTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAA
GTTCTGGTATGACATGGCAGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTC
CATCATCAAACAACAGGTTGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGG
AGCAGATTTGATTTTTGCCTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAA
CAAAACATGGAAAGAGAGGCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTG
GCTAGATAACACTGTGATTAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGA
GTTCAAAGTAGAAGTTTACCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGAC
GGACAGAGACATTATACGAGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACT
AGAAGGGGCTCTGTTGGCCCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGC
TCAGAGACCAATAAGTGGAGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGC
CACAGTGGAAACAGTCAACAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGC
CATGAACCAATGCTGGGAGTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCA
CAGTGAAATTGAAGATTTCCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGC
TAGGGAACAGCTTGATACACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACT
CATGCTTCTAAGCCGTGACGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAG
TAAGATGGAAGAAAGAAAGTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCT
CACTCTAGCAGAGCAGAGTTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTT
TGCTAATGAAGTAAATGCTCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGT
TGTTCTGATCAAGAATTTGTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGA
TGCCAGGAAGCGGGCAAAACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACT
AGAGATATCCAATGACCCAGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTA
TGATACCACAATTAGAACTGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGT
CAGAGACAAATGGGATACTGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGA
TGCTTTGCAGGCATTGGTTGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCAT
GAACCTCATGGATGCACACAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCT
GATTGAGAATAGTCGAGATGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGT
TTCCAAACAAAGCCGGCTTGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGC
AGAGCAAACGCTTCGCTTTCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAA
AGTAGAAGAAAAGCGAGTGGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCAT
CAAACACTGGATCACCATCATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTC
AGAACTGGTGGCTAATGCTGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCC
AATCCCGCAGAACATTGACCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGA
CCGGGTCACCAAGACATACAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCT
AAGTCAGCCAACCCCTCCTCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCA
GGTGTGGCTGTTAGCACTGGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTT
TGATGTCTGGAGGAAAAAGTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGA
TGGGAAGATAACACGTCAGGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACAT
TTTCGACCGAGATGGGGATGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGA
TGCAGATAAAATCGAAGATGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAA
ATACCGGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTT
GGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGC
ATCCCAGGGAATGACCCCCTTCCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGC
TAGTCAGAGTAACCACAGCTGTACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGGTTATCCCATCATCAGGTAGCAA
GTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGC
CAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCG
AGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAA
CTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCG
ATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTA
TATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTAT
GTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACA
AATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAA
ATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTT
TTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAG
GGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTT
TAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTC
CCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTC
AGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTG
AAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTT
TTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACC
ATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTG
TATTAAAATTGCTTGCAGTAACAAATATTTTGTATTTCCTGATTTTCTTTTCAACTATTACCTTATCTATAAATGTTACCCTGGGGTATA

>In-frame_ENST00000256646_ENST00000317713_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=4615AA_start in transcript=16_stop in transcript=13863
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS
PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA
SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA
ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP
SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA
EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK
LQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA
SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI
LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET
VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW
LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ
IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL
ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG
ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA
MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD
ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR
VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK
ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQ
GLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD
MLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ
IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE
DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL
ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK
LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG
EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH
KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQVSQFHDKIEPMLETLENLSSRLRMPPLIPAE
VDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM
AALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKE
RLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII
REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV
NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD
THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ
SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA
KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD
TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR
DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR
VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNI
DRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA
LERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDG
DGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV
KNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPT
PTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL

--------------------------------------------------------------
>In-frame_ENST00000256646_ENST00000564288_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(transcript)=21637nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTG
GAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTAT
GAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGA
GGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACAT
TTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGA
CAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGC
AGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGA
GAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGA
ACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATT
ACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCA
GATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCAT
TGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTG
GATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGAC
GGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTA
TGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGC
CATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACT
CCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTAC
CCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCT
GTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTC
AGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCA
GCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATT
TCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCAT
TGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCT
ACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGA
GACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGC
TTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGC
TGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGG
GGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTT
GCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGAT
TGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGA
TGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGA
ATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCA
TATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAA
TAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGT
TCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGT
GCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGT
GGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTG
GACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGAC
CACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTT
GAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAA
TGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAAC
ACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGA
TGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTC
TGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGA
AGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCA
TCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAA
GCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTT
CTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCAT
GGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAA
GGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGC
CTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGT
TAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGA
CAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAG
ACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCA
GATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCA
GGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAAC
TAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAA
ATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTAC
ATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGA
TACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCA
GGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACT
GGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACA
AAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATT
TCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAA
GGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGG
TAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGA
TACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAAT
AAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCA
ACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTC
TGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAA
AGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGT
AAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACC
AGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCA
GGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAA
CTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGA
AGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTC
AGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAAC
TGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAG
AGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTAC
TGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGA
AAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCA
GAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAA
ACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGAC
CACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGA
GAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAAT
AGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCT
GAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGA
AAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACA
GATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCT
TCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGT
AGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAA
GGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAA
GCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGC
CCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAA
GAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTC
GGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGA
GATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCA
TGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATC
AGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACG
ATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGA
GGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAA
AGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATT
AGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGC
CAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGA
ATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAG
GCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGC
AATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGT
GTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGA
GGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCA
GCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTC
TGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACA
GATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTT
TGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAA
AGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTAT
TCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGG
AACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGG
TTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTC
AGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGT
TCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGAC
AGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGC
CCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAG
GGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCG
GCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGT
CCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGA
TGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTC
CAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACG
GCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCA
GTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAA
GCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCAC
CCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAA
ATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGC
TGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGA
AGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCT
TGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATC
AAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGC
AGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACT
CGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGAT
CTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCA
GGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGT
CGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCA
CTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCT
CCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACA
TATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAG
GGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCAC
AGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCA
GAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGA
TGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACA
GGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCA
GAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCAC
AGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCT
TGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGA
GACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACA
GCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCT
CTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTG
TTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGA
GGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGA
AGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACT
TATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCG
GCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACA
GTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACAC
AGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCA
GTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGTATGAGCAAGCTGCCGA
TGCAGAACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAATTCGCCTGGAACAGGACCAGACCACAGCTCAGCT
TCAGGTACAGAAGGCTTTCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCACCGTAGTGAAATCTTTGGCAC
ATGTGGGGAGGAGCAAAAAACTGTATTACAGGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAATTCAGAGCG
TTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTTTTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGAAACTCGGGC
ACTAATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCAACAAGAGGAAATGAGGCAATTAAGGGAATCTATTGC
TGAACACAAACCTCATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTGAGGAAGGGGAAATGGTGGAAGAAAA
ATACCAGAAAGCAGAAAACATGTATGCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGCCGTGTCCCAGTCCAC
ACAGTTTCATGATAAAATTGAGCCTATGTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACCACTGATCCCTGCTGAAGT
AGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGCCACCGTGGAGCTAGAAAAACTGCAGCCATCCTTTGAGGCCTTGAAGCGCCG
TGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGCAAAAGAAATCCAGGATAAATTGGATCAAATGGTATTCTT
CTGGGAGGACATCAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATTAGCAGAGAAGTTCTGGTATGACATGGC
AGCTCTCCTGACCACCATCAAAGACACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTCCATCATCAAACAACAGGT
TGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGGTCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGGAGCAGATTTGATTTTTGC
CTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGATGAATAATGCTTGGGAGAACTTAAACAAAACATGGAAAGAGAG
GCTAGAAAAACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGGCTATGTTTGACTGGCTAGATAACACTGTGAT
TAAACTCTGCACCATGCCCCCTGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGAGTTCAAAGTAGAAGTTTA
CCAACAGCAAATTGAGATGGAGAAGCTTAATCACCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGACGGACAGAGACATTATACG
AGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTGAGAAAATTGCCCACCGACAGCACAAACTAGAAGGGGCTCTGTTGGC
CCTTGGTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCGAAGAGTTGTTAGATGCTCAGAGACCAATAAGTGG
AGACCCAAAAGTCATTGAAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATCAAGCCACAGTGGAAACAGTCAA
CAAAGCTGGCAATGAGCTTCTTGAATCCAGTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGCCATGAACCAATGCTGGGA
GTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTTCAGTCAACTCTGCAGCAGGCCCAGGGCTTCCACAGTGAAATTGAAGATTT
CCTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACAGGAGGACTTCCTGAAACTGCTAGGGAACAGCTTGATAC
ACATATGGAACTCTATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAGGGCAGACTCATGCTTCTAAGCCGTGA
CGACTCTGGGTCTGGCTCCAAGACAGAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAGTAAGATGGAAGAAAGAAA
GTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGAATTCCAGAATTCCCTACAAGAATTTATCAACTGGCTCACTCTAGCAGAGCAGAG
TTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCCCAGATAGAAGAGCACAAGGTTTTTGCTAATGAAGTAAATGC
TCATCGAGACCAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAAAAGCAGGATGTTGTTCTGATCAAGAATTT
GTTGGTGAGCGTGCAGTCTCGATGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGATGCCAGGAAGCGGGCAAA
ACAATTCCATGAAGCTTGGAAAAAACTGATTGACTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACTAGAGATATCCAATGACCC
AGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAAGACTCTTGGTGGCAAGCAGCCTGTGTATGATACCACAATTAGAAC
TGGCAGAGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAATTTCCTAGGAGAAGTCAGAGACAAATGGGATAC
TGTTTGTGGCAAGTCTGTGGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCATGGATGCTTTGCAGGCATTGGT
TGACTGGTTATACAAGGTGGAGCCACAGCTGGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCATGAACCTCATGGATGCACA
CAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCGTTCAGGTCCTGAAGCGGTCAGGCCGAGAGCTGATTGAGAATAGTCGAGA
TGACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGACACTGTCTGTAAACTCTCTGTTTCCAAACAAAGCCGGCT
TGAGCAGGCCTTAAAACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTTCTGAAGCAGAGCAAACGCTTCGCTT
TCGGGGAGCACTTCCTGATGACACAGAGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAAAGTAGAAGAAAAGCGAGT
GGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATCCTGGCTGTCTGCCACCCCGATTGCATCACAACCATCAAACACTGGATCACCAT
CATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAGCAGCGTCTTGAAACGGCCTTGTCAGAACTGGTGGCTAATGC
TGAGCTCCTGGAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGGGATCAGGAGCCAATCCCGCAGAACATTGA
CCGAGTTAAAGCCCTTATCGCTGAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGACCGGGTCACCAAGACATA
CAAAAGGAAAAACATAGAGCCTACTCACGCGCCTTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCTAAGTCAGCCAACCCCTCC
TCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGATCAACCAGCTTTCTGCCCGCTGGCAGCAGGTGTGGCTGTTAGCACT
GGAGCGGCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAATTTGCCAACTTTGACTTTGATGTCTGGAGGAAAAA
GTATATGCGTTGGATGAATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACCAGGATGGGAAGATAACACGTCA
GGAGTTTATCGATGGCATTTTAGCATCCAAGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACATTTTCGACCGAGATGGGGA
TGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCCCAACAAGGATGCGTATCGACCAACAACCGATGCAGATAAAATCGAAGA
TGAGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGGAGCAGATCGGAGAGAATAAATACCGGTTCTTCCTCGG
CAATCAGTTTGGGGATTCTCAGCAGTTGCGGCTGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGATGGCCTT
GGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGTTCACCATCCTGGGAGTAAAATAAAGCGCTCTGATTCCAGCTCTTCGATTTCCAG
TCAGTCTCCCATAGCACGAGGTAGAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGCATCCCAGGGAATGACCCCCTT
CCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCCGGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGCTAGTCAGAGTAACCACAGCTG
TACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGACTTCACTTCAGTTCTCTCGCTGTTATGACAAACCCTGGTTGGT
AAACAGTAAAGCTGGCACCCCTATCAGGGACAGCCATTCTCCTGACCTCCAGCTGCCCACCCCCGAGGTTATCCCATCATCAGGTAGCAA
GTTGAAACGACCAACACCAACTTTTCATTCTAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCCACAGGTGC
CAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCTGGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCG
AGGAAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGACACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAA
CTCCAGGAGAGGGCTAAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTCCCCCAGGACTCCAGGTCCCAAGCG
ATAACACTGTCTAAGCACCCCCAAGCCACTATCCACTTTGAATCCTGCTCCATACATTGGGTGTATATTTATTCTGAACGGGAGAAGTTA
TATTGTTAAAAGTGTAAAAGAATAATTGTGTTATGAAGCTGCCTTATTTTTTTTCTTTTTGTAAGTTACTATTTTCATGTGAATATTTAT
GTAGATAAAATTTGCCTCCTGGTAACCCTGTAATGGATGGGGCCCAGAAATGAAATATTTGAGAAAAACAAGTGAAAAGGTCAAGATACA
AATGTGTATTAAAAAAAAAAAAGCCTATTAATAGGGTTTCTGCGCGGTGCAGGGTTGTAAACCTGCTTTATCTTTTAGGATTATTCCTAA
ATGCATCTTCTTTATAAACTTGACTTGCTATCTCAGCAAGATAAATTATATTAAAAAAATAAGAATCCTGCAGTGTTTAAGGAACTCTTT
TTTTGTAAATCACGGACACCTCAATTAGCAAGAACTGAGGGGAGGGCTTTTTCCATTGTTTAATGTTTTGTGATTTTTAGCTAAAGAGAG
GGAACCTCATCTAAGTAACATTTGCACATGATACAGCAAAAGGAGTTCATTGCAATACTGTCTTTGGATATTGTTTCAGTACTGGGTGTT
TAAAGGACAAATAGCTGCTAGAATTCAGGGGTAAATGTAAGTGTTCAGAAAACGTCAGAACATTTGGGGTTTTAAACTGATTTGTTGCTC
CCTATCCAGCCTAGACACCAGTAACTCTTGTGTTCACCAGGACCCAGACCCTTGGCAAGGGATAGGCTCGTTGGTGACATTGTGAATTTC
AGATTTGTTTTATCCACTTTTTTTGCTATTTATTTAAATGGTCGATCAACTTCCCACAAACTGAGGAATGAATTCCACGAGCCTGTTCTG
AAAATGTGGACGTAAGACAAACACGTGCTCGTCCTTTAATGGAGTTCACCAGCACACTTGTTAACCAGTCCTGTTTGCTTTCGTCTTTTT
TTGTGCGTAATAAAGTCAACTGACCAAGTGACCATGAAAAGGGGCTGTCTGGGGCTCCTGTTTTTTAGCTGCTGTTCTTCAGCTCCGACC
ATGTTGCTGTGTGATTATCTCAATTGGTTTTAATTGAGGCAGAAACTGAAGCTCTACCAATGAACTGTTTAGAAACAAGACACACTTTTG
TATTAAAATTGCTTGCAGTAACAAATATTTTGTATTTCCTGATTTTCTTTTCAACTATTACCTTATCTATAAATGTTACCCTGGGGTATA
ATCATGTTGTAGGTACTTAAATGCATTCCGCAAATCAAAATATCTTGATGGATAAATTATAGAGCTTAATAGATCTTGTTTTATTTCATC

>In-frame_ENST00000256646_ENST00000564288_TCGA-A2-A0YE-01A_NOTCH2_chr1_120572529_-_MACF1_chr1_39775242_length(amino acids)=6745AA_start in transcript=16_stop in transcript=20253
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQA
HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ
DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKG
YEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEI
RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM
TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT
QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ
LAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA
LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGL
LDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA
CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALF
LPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR
LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETE
DSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH
QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIA
GGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT
CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGL
VDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN
AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL
SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK
RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLG
KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ
VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNAR
VKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA
LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSW
VTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL
EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSE
QTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ
ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS
NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ
EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE
LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE
KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK
QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ
VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS
GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ
FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC
QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS
VGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA
QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME
KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ
AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV
ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL
LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN
EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG
SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE
MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ
EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE
HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ
AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR
HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL
SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK
FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS
DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ
KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH
IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE
CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT
IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE
DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE
LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNE
LLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY
SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIAS
PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA
WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKS
VERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV
KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA
VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKAL
IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK
LNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY
YEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLV
KNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPS
SPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRA

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Fusion Gene PPI Analysis for NOTCH2-MACF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOTCH2-MACF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NOTCH2-MACF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOTCH2C1857761Alagille Syndrome 25CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNOTCH2C0917715Hajdu-Cheney Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNOTCH2C0004114Astrocytoma1CTD_human
HgeneNOTCH2C0006142Malignant neoplasm of breast1CGI;CTD_human
HgeneNOTCH2C0007114Malignant neoplasm of skin1CTD_human
HgeneNOTCH2C0007137Squamous cell carcinoma1CTD_human
HgeneNOTCH2C0007873Uterine Cervical Neoplasm1CTD_human
HgeneNOTCH2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneNOTCH2C0017636Glioblastoma1CTD_human
HgeneNOTCH2C0024121Lung Neoplasms1CTD_human
HgeneNOTCH2C0024623Malignant neoplasm of stomach1CTD_human
HgeneNOTCH2C0027626Neoplasm Invasiveness1CTD_human
HgeneNOTCH2C0037286Skin Neoplasms1CTD_human
HgeneNOTCH2C0038356Stomach Neoplasms1CTD_human
HgeneNOTCH2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNOTCH2C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneNOTCH2C0242379Malignant neoplasm of lung1CTD_human
HgeneNOTCH2C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNOTCH2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNOTCH2C0280785Diffuse Astrocytoma1CTD_human
HgeneNOTCH2C0334579Anaplastic astrocytoma1CTD_human
HgeneNOTCH2C0334580Protoplasmic astrocytoma1CTD_human
HgeneNOTCH2C0334581Gemistocytic astrocytoma1CTD_human
HgeneNOTCH2C0334582Fibrillary Astrocytoma1CTD_human
HgeneNOTCH2C0334583Pilocytic Astrocytoma1CTD_human
HgeneNOTCH2C0334584Spongioblastoma1CTD_human
HgeneNOTCH2C0334588Giant Cell Glioblastoma1CTD_human
HgeneNOTCH2C0334596Medulloepithelioma1CTD_human
HgeneNOTCH2C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNOTCH2C0547065Mixed oligoastrocytoma1CTD_human
HgeneNOTCH2C0678222Breast Carcinoma1CGI;CTD_human
HgeneNOTCH2C0700367Ependymoblastoma1CTD_human
HgeneNOTCH2C0750935Cerebral Astrocytoma1CTD_human
HgeneNOTCH2C0750936Intracranial Astrocytoma1CTD_human
HgeneNOTCH2C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneNOTCH2C1257931Mammary Neoplasms, Human1CTD_human
HgeneNOTCH2C1458155Mammary Neoplasms1CTD_human
HgeneNOTCH2C1621958Glioblastoma Multiforme1CTD_human
HgeneNOTCH2C1704230Grade I Astrocytoma1CTD_human
HgeneNOTCH2C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneNOTCH2C2930967Gastro-enteropancreatic neuroendocrine tumor1CTD_human
HgeneNOTCH2C2930971Acroosteolysis dominant type1ORPHANET
HgeneNOTCH2C4048328cervical cancer1CTD_human
HgeneNOTCH2C4704874Mammary Carcinoma, Human1CTD_human
TgeneMACF1C0036572Seizures2GENOMICS_ENGLAND
TgeneMACF1C0266463Lissencephaly2GENOMICS_ENGLAND
TgeneMACF1C1855677Brainstem dysplasia2GENOMICS_ENGLAND
TgeneMACF1C3714756Intellectual Disability2GENOMICS_ENGLAND