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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOTCH2-PHTF1 (FusionGDB2 ID:59379)

Fusion Gene Summary for NOTCH2-PHTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2-PHTF1
Fusion gene ID: 59379
HgeneTgene
Gene symbol

NOTCH2

PHTF1

Gene ID

4853

10745

Gene namenotch receptor 2putative homeodomain transcription factor 1
SynonymsAGS2|HJCYS|hN2PHTF
Cytomap

1p12

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 2Notch homolog 2notch 2putative homeodomain transcription factor 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256646, ENST00000602566, 
ENST00000493703, 		ENST00000393357, 
ENST00000369596, ENST00000369598, 
ENST00000369600, ENST00000369604, 
ENST00000357783, ENST00000447664, 
ENST00000474926, 
Fusion gene scores* DoF score26 X 22 X 14=80084 X 4 X 2=32
# samples 353
** MAII scorelog2(35/8008*10)=-4.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2 [Title/Abstract] AND PHTF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOTCH2(120539620)-PHTF1(114241009), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2-PHTF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-PHTF1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NOTCH2-PHTF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

HgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH2

GO:0010838

positive regulation of keratinocyte proliferation

18469519

HgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH2

GO:2000249

regulation of actin cytoskeleton reorganization

18469519


check buttonFusion gene breakpoints across NOTCH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PHTF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A44R-06ANOTCH2chr1

120539620

-PHTF1chr1

114241009

-


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Fusion Gene ORF analysis for NOTCH2-PHTF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000256646ENST00000393357NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
Frame-shiftENST00000256646ENST00000369596NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
Frame-shiftENST00000256646ENST00000369598NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
Frame-shiftENST00000256646ENST00000369600NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
Frame-shiftENST00000256646ENST00000369604NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-intronENST00000256646ENST00000357783NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-intronENST00000256646ENST00000447664NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-5UTRENST00000256646ENST00000474926NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
In-frameENST00000602566ENST00000393357NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
In-frameENST00000602566ENST00000369596NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
In-frameENST00000602566ENST00000369598NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
In-frameENST00000602566ENST00000369600NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
In-frameENST00000602566ENST00000369604NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-intronENST00000602566ENST00000357783NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-intronENST00000602566ENST00000447664NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
5CDS-5UTRENST00000602566ENST00000474926NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-3CDSENST00000493703ENST00000393357NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-3CDSENST00000493703ENST00000369596NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-3CDSENST00000493703ENST00000369598NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-3CDSENST00000493703ENST00000369600NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-3CDSENST00000493703ENST00000369604NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-intronENST00000493703ENST00000357783NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-intronENST00000493703ENST00000447664NOTCH2chr1

120539620

-PHTF1chr1

114241009

-
intron-5UTRENST00000493703ENST00000474926NOTCH2chr1

120539620

-PHTF1chr1

114241009

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000602566NOTCH2chr1120539620-ENST00000393357PHTF1chr1114241009-173010804041099231
ENST00000602566NOTCH2chr1120539620-ENST00000369596PHTF1chr1114241009-173010804041099231
ENST00000602566NOTCH2chr1120539620-ENST00000369598PHTF1chr1114241009-172710804041099231
ENST00000602566NOTCH2chr1120539620-ENST00000369600PHTF1chr1114241009-172710804041099231
ENST00000602566NOTCH2chr1120539620-ENST00000369604PHTF1chr1114241009-172710804041099231

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000602566ENST00000393357NOTCH2chr1120539620-PHTF1chr1114241009-0.0041403650.9958597
ENST00000602566ENST00000369596NOTCH2chr1120539620-PHTF1chr1114241009-0.0041403650.9958597
ENST00000602566ENST00000369598NOTCH2chr1120539620-PHTF1chr1114241009-0.0041460450.995854
ENST00000602566ENST00000369600NOTCH2chr1120539620-PHTF1chr1114241009-0.0041460450.995854
ENST00000602566ENST00000369604NOTCH2chr1120539620-PHTF1chr1114241009-0.0041460450.995854

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Fusion Genomic Features for NOTCH2-PHTF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOTCH2-PHTF1


check button Go to

FGviewer for the breakpoints of chr1:120539620-chr1:114241009

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434105_143250.333333333333342472.0DomainEGF-like 3
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434144_180250.333333333333342472.0DomainEGF-like 4
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434182_219250.333333333333342472.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-43426_63250.333333333333342472.0DomainEGF-like 1
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-43464_102250.333333333333342472.0DomainEGF-like 2
TgenePHTF1chr1:120539620chr1:114241009ENST000003577830156_1500638.0DomainPHTF
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015121_1410638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015473_4930638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015512_5320638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015611_6310638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015645_6650638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000357783015737_7570638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST0000035778301577_970638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST0000035778301599_1190638.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619737_757714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518737_757714.0763.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341645_1648250.333333333333342472.0Compositional biasNote=Poly-Ala
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341994_1997250.333333333333342472.0Compositional biasNote=Poly-Leu
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4342426_2429250.333333333333342472.0Compositional biasNote=Poly-Ser
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341025_1061250.333333333333342472.0DomainEGF-like 27%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341063_1099250.333333333333342472.0DomainEGF-like 28
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341101_1147250.333333333333342472.0DomainEGF-like 29
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341149_1185250.333333333333342472.0DomainEGF-like 30%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341187_1223250.333333333333342472.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341225_1262250.333333333333342472.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341264_1302250.333333333333342472.0DomainEGF-like 33
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341304_1343250.333333333333342472.0DomainEGF-like 34
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341374_1412250.333333333333342472.0DomainEGF-like 35
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434221_258250.333333333333342472.0DomainEGF-like 6
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434260_296250.333333333333342472.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434298_336250.333333333333342472.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434338_374250.333333333333342472.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434375_413250.333333333333342472.0DomainEGF-like 10
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434415_454250.333333333333342472.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434456_492250.333333333333342472.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434494_530250.333333333333342472.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434532_568250.333333333333342472.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434570_605250.333333333333342472.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434607_643250.333333333333342472.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434645_680250.333333333333342472.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434682_718250.333333333333342472.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434720_755250.333333333333342472.0DomainEGF-like 19
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434757_793250.333333333333342472.0DomainEGF-like 20%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434795_831250.333333333333342472.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434833_871250.333333333333342472.0DomainEGF-like 22
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434873_909250.333333333333342472.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434911_947250.333333333333342472.0DomainEGF-like 24%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434949_985250.333333333333342472.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-434987_1023250.333333333333342472.0DomainEGF-like 26%3B calcium-binding
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341425_1677250.333333333333342472.0RegionNote=Negative regulatory region (NRR)
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341425_1465250.333333333333342472.0RepeatNote=LNR 1
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341466_1502250.333333333333342472.0RepeatNote=LNR 2
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341503_1544250.333333333333342472.0RepeatNote=LNR 3
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341827_1871250.333333333333342472.0RepeatNote=ANK 1
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341876_1905250.333333333333342472.0RepeatNote=ANK 2
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341909_1939250.333333333333342472.0RepeatNote=ANK 3
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341943_1972250.333333333333342472.0RepeatNote=ANK 4
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341976_2005250.333333333333342472.0RepeatNote=ANK 5
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4342009_2038250.333333333333342472.0RepeatNote=ANK 6
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341699_2471250.333333333333342472.0Topological domainCytoplasmic
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-43426_1677250.333333333333342472.0Topological domainExtracellular
HgeneNOTCH2chr1:120539620chr1:114241009ENST00000256646-4341678_1698250.333333333333342472.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST0000036960416196_150714.0763.0DomainPHTF
TgenePHTF1chr1:120539620chr1:114241009ENST0000039335715186_150714.0763.0DomainPHTF
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619121_141714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619473_493714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619512_532714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619611_631714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003696041619645_665714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000369604161977_97714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000369604161999_119714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518121_141714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518473_493714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518512_532714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518611_631714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST000003933571518645_665714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000393357151877_97714.0763.0TransmembraneHelical
TgenePHTF1chr1:120539620chr1:114241009ENST00000393357151899_119714.0763.0TransmembraneHelical


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Fusion Gene Sequence for NOTCH2-PHTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000602566_ENST00000393357_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(transcript)=1730nt_BP=1080nt
AGACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTTAATAGTTGAATGTTGAAGGAGAGGATGCCA
AGGGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAA
TGCCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCC
ACTTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGGCACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTC
CACCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCCTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGT
GTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGA
ACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACT
GCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGT
GCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCA
CTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGAC
ACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCC
TGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAG
GAGCTGGACACACCATTTAGACTCTATGGACTGACAATGAATCCCTTAATCTACAATATCACAAGAGTAGTTATCCTTTCTGCTGTCTCA
GGTGTTATAAGTGATCTTCTAGGATTTAATATAAGACTGTGGAAAATTAAATCATAAGCTGAGTAAATGCCTGGACTCTCCCCTGGCTGG
TATCAAAACTTACCTATCAAGGAAAGTGATGACTGCAGAAACCAGTGAGATACCCACCTGCTTGTTCACATGCACAGGTGCTCTCAGCTC
TGCCAAAGCGAATGAATGGTGTTTCCGGAGGAGCAAGTCCTTTTCCAACTGGGTGTGCATGCTAAAAACCTGTATTTTCATGCTTTTCAA
ACAACATGAATAGTCAGCTGACTAAAGACTGTGTGTGTTGTGGTAACACAAAGACAATTTTGTAAGTTTGCGCTTCAGTACTGTGACAGT
TATGTTTACTGGACATAGTCTTTTGGGCAACTATGATAGATGCCCAAAGCATGAAGCAAATATCTTTTATTGGAAATATGCAAATTCAAT
ACTTTTCCATTATAGTCTATAGAACTGGAGATTTCATTTCTCTATCAAAGAGAGATCAAGCGAACTATTTTAGGTTAAATCCGAATAAAA

>In-frame_ENST00000602566_ENST00000393357_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(amino acids)=231AA_start in transcript=404_stop in transcript=1099
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY

--------------------------------------------------------------
>In-frame_ENST00000602566_ENST00000369596_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(transcript)=1730nt_BP=1080nt
AGACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTTAATAGTTGAATGTTGAAGGAGAGGATGCCA
AGGGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAA
TGCCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCC
ACTTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGGCACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTC
CACCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCCTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGT
GTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGA
ACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACT
GCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGT
GCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCA
CTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGAC
ACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCC
TGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAG
GAGCTGGACACACCATTTAGACTCTATGGACTGACAATGAATCCCTTAATCTACAATATCACAAGAGTAGTTATCCTTTCTGCTGTCTCA
GGTGTTATAAGTGATCTTCTAGGATTTAATATAAGACTGTGGAAAATTAAATCATAAGCTGAGTAAATGCCTGGACTCTCCCCTGGCTGG
TATCAAAACTTACCTATCAAGGAAAGTGATGACTGCAGAAACCAGTGAGATACCCACCTGCTTGTTCACATGCACAGGTGCTCTCAGCTC
TGCCAAAGCGAATGAATGGTGTTTCCGGAGGAGCAAGTCCTTTTCCAACTGGGTGTGCATGCTAAAAACCTGTATTTTCATGCTTTTCAA
ACAACATGAATAGTCAGCTGACTAAAGACTGTGTGTGTTGTGGTAACACAAAGACAATTTTGTAAGTTTGCGCTTCAGTACTGTGACAGT
TATGTTTACTGGACATAGTCTTTTGGGCAACTATGATAGATGCCCAAAGCATGAAGCAAATATCTTTTATTGGAAATATGCAAATTCAAT
ACTTTTCCATTATAGTCTATAGAACTGGAGATTTCATTTCTCTATCAAAGAGAGATCAAGCGAACTATTTTAGGTTAAATCCGAATAAAA

>In-frame_ENST00000602566_ENST00000369596_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(amino acids)=231AA_start in transcript=404_stop in transcript=1099
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY

--------------------------------------------------------------
>In-frame_ENST00000602566_ENST00000369598_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(transcript)=1727nt_BP=1080nt
AGACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTTAATAGTTGAATGTTGAAGGAGAGGATGCCA
AGGGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAA
TGCCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCC
ACTTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGGCACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTC
CACCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCCTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGT
GTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGA
ACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACT
GCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGT
GCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCA
CTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGAC
ACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCC
TGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAG
GAGCTGGACACACCATTTAGACTCTATGGACTGACAATGAATCCCTTAATCTACAATATCACAAGAGTAGTTATCCTTTCTGCTGTCTCA
GGTGTTATAAGTGATCTTCTAGGATTTAATATAAGACTGTGGAAAATTAAATCATAAGCTGAGTAAATGCCTGGACTCTCCCCTGGCTGG
TATCAAAACTTACCTATCAAGGAAAGTGATGACTGCAGAAACCAGTGAGATACCCACCTGCTTGTTCACATGCACAGGTGCTCTCAGCTC
TGCCAAAGCGAATGAATGGTGTTTCCGGAGGAGCAAGTCCTTTTCCAACTGGGTGTGCATGCTAAAAACCTGTATTTTCATGCTTTTCAA
ACAACATGAATAGTCAGCTGACTAAAGACTGTGTGTGTTGTGGTAACACAAAGACAATTTTGTAAGTTTGCGCTTCAGTACTGTGACAGT
TATGTTTACTGGACATAGTCTTTTGGGCAACTATGATAGATGCCCAAAGCATGAAGCAAATATCTTTTATTGGAAATATGCAAATTCAAT
ACTTTTCCATTATAGTCTATAGAACTGGAGATTTCATTTCTCTATCAAAGAGAGATCAAGCGAACTATTTTAGGTTAAATCCGAATAAAA

>In-frame_ENST00000602566_ENST00000369598_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(amino acids)=231AA_start in transcript=404_stop in transcript=1099
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY

--------------------------------------------------------------
>In-frame_ENST00000602566_ENST00000369600_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(transcript)=1727nt_BP=1080nt
AGACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTTAATAGTTGAATGTTGAAGGAGAGGATGCCA
AGGGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAA
TGCCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCC
ACTTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGGCACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTC
CACCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCCTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGT
GTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGA
ACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACT
GCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGT
GCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCA
CTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGAC
ACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCC
TGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAG
GAGCTGGACACACCATTTAGACTCTATGGACTGACAATGAATCCCTTAATCTACAATATCACAAGAGTAGTTATCCTTTCTGCTGTCTCA
GGTGTTATAAGTGATCTTCTAGGATTTAATATAAGACTGTGGAAAATTAAATCATAAGCTGAGTAAATGCCTGGACTCTCCCCTGGCTGG
TATCAAAACTTACCTATCAAGGAAAGTGATGACTGCAGAAACCAGTGAGATACCCACCTGCTTGTTCACATGCACAGGTGCTCTCAGCTC
TGCCAAAGCGAATGAATGGTGTTTCCGGAGGAGCAAGTCCTTTTCCAACTGGGTGTGCATGCTAAAAACCTGTATTTTCATGCTTTTCAA
ACAACATGAATAGTCAGCTGACTAAAGACTGTGTGTGTTGTGGTAACACAAAGACAATTTTGTAAGTTTGCGCTTCAGTACTGTGACAGT
TATGTTTACTGGACATAGTCTTTTGGGCAACTATGATAGATGCCCAAAGCATGAAGCAAATATCTTTTATTGGAAATATGCAAATTCAAT
ACTTTTCCATTATAGTCTATAGAACTGGAGATTTCATTTCTCTATCAAAGAGAGATCAAGCGAACTATTTTAGGTTAAATCCGAATAAAA

>In-frame_ENST00000602566_ENST00000369600_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(amino acids)=231AA_start in transcript=404_stop in transcript=1099
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY

--------------------------------------------------------------
>In-frame_ENST00000602566_ENST00000369604_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(transcript)=1727nt_BP=1080nt
AGACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTTAATAGTTGAATGTTGAAGGAGAGGATGCCA
AGGGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAA
TGCCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCC
ACTTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGGCACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTC
CACCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCCTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGT
GTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGA
ACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACT
GCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGT
GCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCA
CTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGAC
ACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCC
TGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAG
GAGCTGGACACACCATTTAGACTCTATGGACTGACAATGAATCCCTTAATCTACAATATCACAAGAGTAGTTATCCTTTCTGCTGTCTCA
GGTGTTATAAGTGATCTTCTAGGATTTAATATAAGACTGTGGAAAATTAAATCATAAGCTGAGTAAATGCCTGGACTCTCCCCTGGCTGG
TATCAAAACTTACCTATCAAGGAAAGTGATGACTGCAGAAACCAGTGAGATACCCACCTGCTTGTTCACATGCACAGGTGCTCTCAGCTC
TGCCAAAGCGAATGAATGGTGTTTCCGGAGGAGCAAGTCCTTTTCCAACTGGGTGTGCATGCTAAAAACCTGTATTTTCATGCTTTTCAA
ACAACATGAATAGTCAGCTGACTAAAGACTGTGTGTGTTGTGGTAACACAAAGACAATTTTGTAAGTTTGCGCTTCAGTACTGTGACAGT
TATGTTTACTGGACATAGTCTTTTGGGCAACTATGATAGATGCCCAAAGCATGAAGCAAATATCTTTTATTGGAAATATGCAAATTCAAT
ACTTTTCCATTATAGTCTATAGAACTGGAGATTTCATTTCTCTATCAAAGAGAGATCAAGCGAACTATTTTAGGTTAAATCCGAATAAAA

>In-frame_ENST00000602566_ENST00000369604_TCGA-EB-A44R-06A_NOTCH2_chr1_120539620_-_PHTF1_chr1_114241009_length(amino acids)=231AA_start in transcript=404_stop in transcript=1099
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NOTCH2-PHTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOTCH2-PHTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOTCH2-PHTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOTCH2C1857761Alagille Syndrome 25CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNOTCH2C0917715Hajdu-Cheney Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNOTCH2C0004114Astrocytoma1CTD_human
HgeneNOTCH2C0006142Malignant neoplasm of breast1CGI;CTD_human
HgeneNOTCH2C0007114Malignant neoplasm of skin1CTD_human
HgeneNOTCH2C0007137Squamous cell carcinoma1CTD_human
HgeneNOTCH2C0007873Uterine Cervical Neoplasm1CTD_human
HgeneNOTCH2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneNOTCH2C0017636Glioblastoma1CTD_human
HgeneNOTCH2C0024121Lung Neoplasms1CTD_human
HgeneNOTCH2C0024623Malignant neoplasm of stomach1CTD_human
HgeneNOTCH2C0027626Neoplasm Invasiveness1CTD_human
HgeneNOTCH2C0037286Skin Neoplasms1CTD_human
HgeneNOTCH2C0038356Stomach Neoplasms1CTD_human
HgeneNOTCH2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNOTCH2C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneNOTCH2C0242379Malignant neoplasm of lung1CTD_human
HgeneNOTCH2C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNOTCH2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNOTCH2C0280785Diffuse Astrocytoma1CTD_human
HgeneNOTCH2C0334579Anaplastic astrocytoma1CTD_human
HgeneNOTCH2C0334580Protoplasmic astrocytoma1CTD_human
HgeneNOTCH2C0334581Gemistocytic astrocytoma1CTD_human
HgeneNOTCH2C0334582Fibrillary Astrocytoma1CTD_human
HgeneNOTCH2C0334583Pilocytic Astrocytoma1CTD_human
HgeneNOTCH2C0334584Spongioblastoma1CTD_human
HgeneNOTCH2C0334588Giant Cell Glioblastoma1CTD_human
HgeneNOTCH2C0334596Medulloepithelioma1CTD_human
HgeneNOTCH2C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNOTCH2C0547065Mixed oligoastrocytoma1CTD_human
HgeneNOTCH2C0678222Breast Carcinoma1CGI;CTD_human
HgeneNOTCH2C0700367Ependymoblastoma1CTD_human
HgeneNOTCH2C0750935Cerebral Astrocytoma1CTD_human
HgeneNOTCH2C0750936Intracranial Astrocytoma1CTD_human
HgeneNOTCH2C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneNOTCH2C1257931Mammary Neoplasms, Human1CTD_human
HgeneNOTCH2C1458155Mammary Neoplasms1CTD_human
HgeneNOTCH2C1621958Glioblastoma Multiforme1CTD_human
HgeneNOTCH2C1704230Grade I Astrocytoma1CTD_human
HgeneNOTCH2C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneNOTCH2C2930967Gastro-enteropancreatic neuroendocrine tumor1CTD_human
HgeneNOTCH2C2930971Acroosteolysis dominant type1ORPHANET
HgeneNOTCH2C4048328cervical cancer1CTD_human
HgeneNOTCH2C4704874Mammary Carcinoma, Human1CTD_human