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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOTCH2NL-PDE4DIP (FusionGDB2 ID:59398)

Fusion Gene Summary for NOTCH2NL-PDE4DIP

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2NL-PDE4DIP
Fusion gene ID: 59398
HgeneTgene
Gene symbol

NOTCH2NL

PDE4DIP

Gene ID

100996763

9659

Gene namenotch 2 N-terminal like Bphosphodiesterase 4D interacting protein
SynonymsN2N|NOTCH2NL|NOTCH2NLACMYA2|MMGL
Cytomap

1q21.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionnotch homolog 2 N-terminal-like protein BNotch homolog 2 N-terminal-like protein Anotch homolog 2 N-terminal-like proteinmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000362074, ENST00000344859, 
ENST00000369340, ENST00000479995, 
ENST00000313382, ENST00000369354, 
ENST00000369356, ENST00000530740, 
ENST00000369359, ENST00000369351, 
ENST00000369349, ENST00000369347, 
ENST00000369348, ENST00000524974, 
ENST00000313431, ENST00000529945, 
ENST00000479408, ENST00000493130, 
ENST00000478649, ENST00000369345, 
Fusion gene scores* DoF score23 X 4 X 14=128812 X 9 X 8=864
# samples 2213
** MAII scorelog2(22/1288*10)=-2.54955716458996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2NL [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOTCH2NL(145248894)-PDE4DIP(145021167), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2NL

GO:0021987

cerebral cortex development

29561261|29856954|29856955

HgeneNOTCH2NL

GO:0045747

positive regulation of Notch signaling pathway

29856954|29856955

TgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across NOTCH2NL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PDE4DIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5527NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-


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Fusion Gene ORF analysis for NOTCH2NL-PDE4DIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000362074ENST00000313382NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369354NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369356NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000530740NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369359NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369351NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369349NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369347NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369348NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000524974NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000313431NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000529945NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000479408NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000493130NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000478649NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000362074ENST00000369345NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
In-frameENST00000344859ENST00000313382NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369354NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369356NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000530740NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369359NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369351NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369349NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369347NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369348NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000524974NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000313431NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000529945NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000479408NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000493130NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000478649NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000344859ENST00000369345NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
In-frameENST00000369340ENST00000313382NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369354NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369356NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000530740NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369359NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369351NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369349NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369347NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369348NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000524974NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000313431NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000529945NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000479408NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000493130NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000478649NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
5CDS-intronENST00000369340ENST00000369345NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-3CDSENST00000479995ENST00000313382NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369354NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369356NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000530740NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369359NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369351NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369349NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369347NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369348NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000524974NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000313431NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000529945NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000479408NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000493130NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000478649NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-
intron-intronENST00000479995ENST00000369345NOTCH2NLchr1

145248894

+PDE4DIPchr1

145021167

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000362074NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-813740013471022322
ENST00000344859NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-813740013471022322
ENST00000369340NOTCH2NLchr1145248894+ENST00000313382PDE4DIPchr1145021167-821948240271842260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000362074ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.0078549370.992145
ENST00000344859ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.0078549370.992145
ENST00000369340ENST00000313382NOTCH2NLchr1145248894+PDE4DIPchr1145021167-0.007742990.992257

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Fusion Genomic Features for NOTCH2NL-PDE4DIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOTCH2NL-PDE4DIP


check button Go to

FGviewer for the breakpoints of chr1:145248894-chr1:145021167

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461002_10436.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461096_11246.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461212_12406.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461346_13856.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461431_14556.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046162_2056.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461736_17606.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461840_20776.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820462273_23126.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046238_3186.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046350_6846.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000031338204641_1326.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313382046743_9366.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191002_104301133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191096_112401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191212_124001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191346_138501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191431_145501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019162_20501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191736_176001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191840_207701133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310192273_231201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019238_31801133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019350_68401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000031343101941_13201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000313431019743_93601133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041002_10430174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041096_11240174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041212_12400174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041346_13850174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041431_14550174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704162_2050174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041736_17600174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041840_20770174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347042273_23120174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704238_3180174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704350_6840174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693470441_1320174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934704743_9360174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071002_104377.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071096_112477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071212_124077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071346_138577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071431_145577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807162_20577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071736_176077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071840_207777.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348072273_231277.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807238_31877.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807350_68477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934807743_93677.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231002_10430970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231096_11240970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231212_12400970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231346_13850970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231431_14550970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023162_2050970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231736_17600970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231840_20770970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490232273_23120970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023238_3180970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023350_6840970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036934902341_1320970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369349023743_9360970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221002_10430989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221096_11240989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221212_12400989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221346_13850989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221431_14550989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022162_2050989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221736_17600989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221840_20770989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510222273_23120989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022238_3180989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022350_6840989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935102241_1320989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369351022743_9360989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441002_104302347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441096_112402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441212_124002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441346_138502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441431_145502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044162_20502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441736_176002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441840_207702347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540442273_231202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044238_31802347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044350_68402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935404441_13202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369354044743_93602347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441002_104302363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441096_112402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441212_124002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441346_138502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441431_145502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044162_20502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441736_176002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441840_207702363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560442273_231202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044238_31802363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044350_68402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST0000036935604441_13202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369356044743_93602363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003133820461551_16426.6666666666666672241.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003134310191551_164201133.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369347041551_16420174.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST00000369348071551_164277.66666666666667311.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693490231551_16420970.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693510221551_16420989.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693540441551_164202347.0DomainOlduvai
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693560441551_164202363.0DomainOlduvai

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26105_14112.666666666666666416.3333333333333DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26143_18012.666666666666666416.3333333333333DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+26182_21912.666666666666666416.3333333333333DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+261_2412.666666666666666416.3333333333333DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+2625_6312.666666666666666416.3333333333333DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000344859+2666_10412.666666666666666416.3333333333333DomainEGF-like 3
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25105_14112.666666666666666237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25143_18012.666666666666666237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+25182_21912.666666666666666237.0DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+251_2412.666666666666666237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+2525_6312.666666666666666237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000362074+2566_10412.666666666666666237.0DomainEGF-like 3
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36105_14112.666666666666666237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36143_18012.666666666666666237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+36182_21912.666666666666666237.0DomainEGF-like 6
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+361_2412.666666666666666237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+3625_6312.666666666666666237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145248894chr1:145021167ENST00000369340+3666_10412.666666666666666237.0DomainEGF-like 3
TgenePDE4DIPchr1:145248894chr1:145021167ENST000003693480741_13277.66666666666667311.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for NOTCH2NL-PDE4DIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000362074_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(transcript)=8137nt_BP=400nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAAGATTATTTTGCAGAGGATGATGGGGAGATGGTACCCAGAACGAGTCACA
CAGCAGCTTTTCTTAGTGACACTAAAGATCGAGGCCCTCCAGTGCAGTCACAGATCTGGAGAAGTGGTGAAAAGGTCCCGTTTGTGCAGA
CATATTCCTTGAGAGCATTTGAGAAACCCCCTCAGGTACAGACCCAGGCTCTTCGAGACTTTGAGAAGCACCTCAATGACCTGAAGAAGG
AGAACTTCAGCCTCAAGCTGCGCATCTACTTCCTGGAGGAGCGCATGCAACAGAAGTATGAGGCCAGCCGGGAGGACATCTACAAGCGGA
ACATTGAGCTGAAGGTTGAAGTGGAGAGCTTGAAACGAGAACTCCAGGACAAGAAACAGCATCTGGATAAAACATGGGCTGATGTGGAGA
ATCTCAACAGTCAGAATGAAGCTGAGCTCCGACGCCAGTTTGAGGAGCGACAGCAGGAGACGGAGCATGTTTATGAGCTCTTGGAGAATA
AGATCCAGCTTCTGCAGGAGGAATCCAGGCTAGCAAAGAATGAAGCTGCGCGGATGGCAGCTCTGGTGGAAGCAGAGAAGGAGTGTAACC
TGGAGCTCTCAGAGAAACTGAAGGGAGTCACCAAAAACTGGGAAGATGTACCAGGAGACCAGGTCAAGCCCGACCAATACACTGAGGCCC
TGGCCCAGAGGGACAAGAGAATTGAAGAACTGAATCAGAGCCTGGCTGCCCAGGAGAGGCTTGTAGAACAGCTATCTCGGGAGAAACAAC
AACTGCTACATCTGTTGGAGGAGCCAACTAGCATGGAAGTGCAGCCCATGACTGAAGAGTTGCTGAAACAACAAAAGCTGAATTCACATG
AGACCACTATAACTCAGCAGTCTGTATCTGATTCCCACTTGGCAGAACTCCAGGAAAAAATCCAGCAAACAGAGGCCACCAACAAGATTC
TTCAAGAGAAACTTAATGAAATGAGCTATGAACTAAAGTGTGCTCAGGAGTCGTCTCAAAAGCAAGATGGTACAATTCAGAACCTCAAGG
AAACTCTGAAAAGCAGGGAACGTGAGACTGAGGAGTTGTACCAGGTAATTGAAGGTCAAAATGACACAATGGCAAAGCTTCGAGAAATGC
TGCACCAAAGCCAGCTTGGACAACTTCACAGCTCAGAGGGTACTTCTCCAGCTCAGCAACAGGTAGCTCTGCTTGATCTTCAGAGTGCTT
TATTCTGCAGCCAACTTGAAATACAGAAGCTCCAGAGGGTGGTACGACAGAAAGAGCGCCAACTGGCTGATGCCAAACAATGTGTGCAAT
TTGTAGAGGCTGCAGCACACGAGAGTGAACAGCAGAAAGAGGCTTCTTGGAAACATAACCAGGAATTGCGAAAAGCCTTGCAGCAGCTAC
AAGAAGAATTGCAGAATAAGAGCCAACAGCTTCGTGCCTGGGAGGCTGAAAAATACAATGAGATTCGAACCCAGGAACAAAACATCCAGC
ACCTAAACCATAGTCTGAGTCACAAGGAGCAGTTGCTTCAGGAATTTCGGGAGCTCCTACAGTATCGAGATAACTCAGACAAAACCCTTG
AAGCAAATGAAATGTTGCTTGAGAAACTTCGCCAGCGAATACATGATAAAGCTGTTGCTCTGGAGCGGGCTATAGATGAAAAATTCTCTG
CTCTAGAAGAGAAAGAAAAAGAACTGCGCCAGCTTCGTCTTGCTGTGAGAGAGCGAGATCATGACTTAGAGAGACTGCGCGATGTCCTCT
CCTCCAATGAAGCTACTATGCAAAGTATGGAGAGTCTCCTGAGGGCCAAAGGCCTGGAAGTGGAACAGTTATCTACTACCTGTCAAAACC
TCCAGTGGCTGAAAGAAGAAATGGAAACCAAATTTAGCCGTTGGCAGAAGGAACAAGAGAGTATCATTCAGCAGTTACAGACGTCTCTTC
ATGATAGGAACAAAGAAGTGGAGGATCTTAGTGCAACACTGCTCTGCAAACTTGGACCAGGGCAGAGTGAGATAGCAGAGGAGCTGTGCC
AGCGTCTACAGCGAAAGGAAAGGATGCTGCAGGACCTTCTAAGTGATCGAAATAAACAAGTGCTGGAACATGAAATGGAGATTCAAGGCC
TGCTTCAGTCTGTGAGCACCAGGGAGCAGGAAAGCCAAGCTGCTGCAGAGAAGTTGGTGCAAGCCTTAATGGAAAGAAATTCAGAATTAC
AGGCCCTGCGCCAATATTTAGGAGGGAGAGACTCCCTGATGTCCCAAGCACCCATCTCTAACCAACAAGCTGAAGTTACCCCCACTGGCT
GTCTTGGAAAACAGACTGATCAAGGTTCAATGCAGATACCTTCCAGAGATGATAGCACTTCATTGACTGCCAAAGAGGATGTCAGCATAC
CCAGATCCACATTAGGAGACTTGGACACAGTTGCAGGGCTGGAAAAAGAACTGAGTAATGCCAAAGAGGAACTTGAACTCATGGCTAAAA
AAGAAAGAGAAAGTCAGATGGAACTTTCTGCTCTACAGTCCATGATGGCTGTGCAGGAAGAAGAGCTGCAGGTGCAGGCTGCTGATATGG
AGTCTCTGACCAGGAACATACAGATTAAAGAAGATCTCATAAAGGACCTGCAAATGCAACTGGTTGATCCTGAAGACATACCAGCTATGG
AACGCCTGACCCAGGAAGTCTTACTTCTTCGGGAAAAAGTTGCTTCAGTAGAATCCCAGGGTCAAGAAATTTCAGGAAACCGAAGACAAC
AGTTGCTGCTGATGCTAGAAGGACTAGTAGATGAACGGAGTCGGCTCAATGAGGCCTTACAAGCAGAGAGACAGCTCTATAGCAGTCTGG
TGAAGTTCCATGCCCATCCAGAGAGCTCTGAGAGAGACCGAACTCTGCAGGTGGAACTGGAAGGGGCTCAGGTGTTACGCAGTCGGCTAG
AAGAAGTTCTTGGAAGAAGCTTGGAGCGCTTAAACAGGCTGGAGACCCTGGCCGCCATTGGAGGTGCAGCTGCAGGGGATGACACCGAAG
ATACAAGCACTGAGTTCACTGACAGTATTGAGGAGGAGGCTGCACACCATAGTCACCAGCAACTTGTCAAGGTGGCTTTGGAGAAAAGTC
TGGCAACTGTGGAGACCCAGAACCCATCTTTTTCCCCTCCTTCTCCGATGGGAGGGGACAGTAACAGGTGTCTTCAGGAAGAAATGCTCC
ACCTGAGGGCTGAGTTCCACCAGCACTTAGAAGAGAAGAGGAAAGCTGAGGAGGAACTGAAGGAGCTAAAGGCTCAAATTGAGGAAGCAG
GATTCTCCTCAGTGTCCCACATCAGGAACACCATGCTGAGCCTTTGCCTTGAGAATGCGGAGCTGAAAGAGCAGATGGGAGAAGCAATGT
CTGATGGATGGGAGATCGAGGAAGACAAGGAGAAGGGCGAGTTGGATAACCAGTCCCAGCCTCGTGACCCTGGGCCTCAGTCAGCGTTTA
GCCTACCAGGGTCCACCCAGCACCTGCGCTCCCAGCTGTCACAATGCAAACAACGCTATCAAGATCTCCAGGAGAAGCTGCTGCTATCAG
AAGCCACTGTCTTTGCTCAGGCTAACGAGCTGGAGAAATACAGAGTTATGCTTACAGGTGAATCCTTGGTGAAGCAGGACAGCAAGCAGA
TCCAGGTGGACCTCCAGGACCTGGGCTATGAGACTTGTGGCCGAAGCGAGAATGAGGCTGAACGGGAGGAAACCACCAGTCCTGAGTGTG
AGGAGCACAACAGCCTCAAGGAAATGGTCCTGATGGAGGGGCTGTGCTCTGAGCAGGGACGCCGGGGCTCAACACTGGCTAGTTCCTCTG
AGAGGAAGCCCTTGGAGAACCAGCTAGGGAAGCAGGAAGAGTTCCGGGTATATGGAAAGTCAGAAAACATCTTGGTCCTACGAAAGGACA
TCAAAGATCTGAAGGCCCAGCTGCAGAATGCCAACAAGGTCATTCAAAACCTCAAGAGCCGGGTCCGGTCCCTCTCAGTTACAAGTGATT
ATTCGTCTAGTCTGGAAAGACCCTGGAAGCTGAGAGCTGTTGGCACCTTGGAGGGGTCTTCACCTCATAGTGTCCCTGATGAGGATGAGG
GGTGGCTGTCTGATGGCACTGGGGCTTTCTACTCTCCAGGGCTTCAGGCCAAAAAGGACCTGGAGAGTCTCATCCAGAGAGTATCCCAGC
TGGAGGCCCAGCTCCCAAAAAATGGACTAGAAGAGAAGCTGGCTGAGGAGCTGAGATCAGCCTCGTGGCCTGGGAAATATGATTCCCTGA
TTCAGGATCAGGCCCGGGAACTGTCTTACCTACGGCAAAAAATACGAGAAGGGAGAGGTATTTGTTATCTTATCACCCGGCATGCAAAAG
ATACAGTAAAATCTTTTGAGGATCTCCTAAGGAGCAATGACATTGACTACTACCTGGGACAGAGCTTCCGGGAGCAACTCGCCCAGGGAA
GCCAGCTGACAGAGAGGCTCACCAGCAAACTCAGCACCAAGGATCATAAAAGTGAGAAAGATCAAGCTGGACTTGAGCCACTGGCCCTCA
GGCTCAGCAGGGAGCTGCAGGAGAAGGAGAAAGTGATTGAAGTCCTGCAGGCCAAGCTGGATGCTCGGTCCCTCACACCCTCCAGCAGCC
ATGCCTTGTCTGACTCCCACCGCTCTCCCAGCAGCACCTCTTTCCTGTCTGATGAACTGGAAGCCTGCTCTGACATGGACATAGTCAGCG
AGTACACACACTATGAAGAGAAGAAAGCTTCTCCCAGTCACTCAGATTCCATCCATCATTCGAGTCATTCTGCTGTGTTGTCTTCTAAAC
CATCATCAACCAGTGCATCTCAGGGGGCTAAGGCCGAATCCAACAGCAACCCCATCAGCTTGCCAACTCCCCAGAATACCCCCAAGGAGG
CCAACCAGGCCCATTCAGGTGCCAGCACTGTTCCTCCTGCTTCCACAGCTACATTGCTGAGCAACGACTTGGAAGCCGACTCTTCCTACT
ACCTCAACTCTGCCCAGCCTCACTCTCCTCCAAGGGGCACCATAGAACTGGGAAGAATCCTAGAGCCTGGGTACCTGGGCAGCAGTGGCA
AGTGGGATGTGATGAGGCCTCAGAAAGGGAGTGTATCTGGGGACCTATCCTCAGGCTCCTCTGTGTACCAGCTTAACTCCAAACCCACAG
GGGCTGACCTGCTGGAAGAGCATCTTGGTGAAATCCGGAACCTGCGCCAGCGCCTGGAGGAATCCATCTGCATCAATGACCGCCTACGGG
AGCAACTGGAACACCGGCTGACCTCTACTGCTCGTGGAAGGGGATCCACTTCTAACTTCTACAGTCAGGGCCTGGAGTCCATACCTCAGC
TCTGCAATGAGAACAGAGTCCTCAGGGAAGACAATCGAAGACTTCAGGCTCAACTGAGTCATGTTTCCAGAGAGCACTCCCAGGAAACAG
AAAGCCTGAGGGAGGCTCTGCTGTCCTCTCGATCCCACCTTCAAGAGCTGGAAAAGGAGCTGGAGCACCAGAAGGTGGAAAGGCAGCAGC
TTTTGGAAGACTTGAGGGAGAAGCAGCAAGAGGTCTTGCATTTCAGGGAGGAACGTCTTTCCCTCCAGGAAAACGACTCCAGACTGCAGC
ACAAGCTGGTTCTCCTGCAGCAACAGTGTGAAGAGAAACAGCAGCTCTTTGAGTCCCTCCAGTCAGAGCTACAAATCTACGAGGCACTTT
ATGGCAATTCCAAGAAGGGGCTGAAAGCTTACAGCCTGGATGCCTGTCACCAAATCCCTTTGAGCAGTGACCTGAGCCACCTGGTGGCAG
AGGTACGAGCTCTGAGAGGGCAGCTGGAGCAGAGCATTCAGGGGAACAATTGTCTGCGACTGCAGCTGCAACAGCAGCTGGAGAGCGGTG
CTGGCAAAGCCAGCCTCAGCCCCTCCTCCATTAACCAGAACTTCCCAGCCAGCACTGACCCTGGAAACAAGCAGCTGCTCCTCCAAGATT
CAGCTGTGTCCCCTCCAGTCCGGGATGTTGGTATGAATTCCCCAGCTCTGGTCTTCCCCAGCTCTGCTTCCTCTACTCCTGGCTCAGAAA
CGCCCATAATCAACAGAGCAAATGGCTTGGGTTTGGATACTTCTCCAGTAATGAAGACCCCTCCCAAGCTAGAGGGTGATGCTACTGATG
GCTCCTTTGCCAATAAGCATGGCCGCCATGTCATTGGCCACATTGATGACTACAGTGCCCTAAGACAGCAGATTGCGGAGGGCAAGCTGC
TGGTCAAAAAGATAGTGTCTCTTGTGAGATCAGCGTGCAGCTTCCCTGGCCTTGAAGCCCAAGGCACAGAGGTGCTAGGCAGCAAAGGTA
TTCATGAGCTTCGGAGCAGCACCAGTGCCCTGCACCATGCCCTAGAGGAGTCAGCTTCCCTCCTCACCATGTTCTGGAGAGCGGCCCTGC
CAAGCACCCACATCCCTGTGCTGCCTGGCAAAGTGGGAGAATCAACAGAAAGGGAACTTCTGGAACTGAGAACCAAAGTATCCAAACAGG
AGCGACTCCTTCAGAGCACAACTGAGCATCTGAAGAACGCCAACCAGCAGAAGGAGAGCATGGAACAGTTCATTGTCAGCCAGCTAACCA
GAACACATGATGTTTTAAAGAAGGCAAGGACTAACTTAGAGGTGAAATCCCTAAGGGCTCTGCCATGTACTCCAGCCTTGTGACCCTTGC
CTTCCAGGAACCATGCAAGAAGCGCAGCCACCAGAAGTCCTTAAAACAGCAGGAAAGGTGGGCCTGTCCCCCTTTTGTGCAGCTACCTAT
CTGCTGAGGAGCATCTGGGCCTCATTCCTCCAAGTCCACGGGAGGGTCCAGAAGAGGGAGTCAGAGATGTATCCTGGTGGAGCTGGGAGA
AAGGCAGAAAGCCTTTCTGACGGCTATGGAATACGATTAGCCAAGGTCCACTTGGCCCAGCACTAAGAAAAAGATGCGTAGTTTGCACAG
AAGGTTTTGTGATCCTGCCTCTCAACAGCCCCAGCAGCTTGGGAACTAGCAAGAGCACATTTCTTGCCTCATCAGCTGTCCTGAGATGGA
AAACTCAGTGAATATAGGACCCTGATTCCGATGAAAGGGGCACGTGGTCCCAATGCTGGAGCTCCTCTGGCAGGTTCTAAAAGCACACTA
CTGAGCAGCGGTGCCCTGCCGGACACTGCTGGCGGGGGCTCAGTGAGCACTACTCACAGATCCACACCTGACCCTGTTGGGTCGAGTCAG
GCTGGGCCTTGGTCTGCACTGTAGCACCTGTGTTCTTTGAGTTCACATCATGAATGTGGTGACTTCCCAGATACCATCTCAGGCTTAACC
TAGCACATCCTATTTCTTTTCTTCTATGATATCCAAATTGGACTGACCTCACTTCAAAGTTGCTGTCCCATTTTGTCACCCTATCTTATC
TCGGGGAAATTGCAGACTGATGGCCAGACCAACTCTGTTGAAATTCTTGCATAGAGCAAACCTGTGCTCATTTTTAAGTGGCATGGGAGA
GGCCCCAAGCCTAGTAAAGCCTAGTCTGTGTCTTCACAGTGCTGGTAGAATGTGTTTGTGTGTATAAATATATGATATAGATTTATATAT
GTTGCTAACGCCATATATTGAAGGCCAACATAACTGGTGGACAGGGTGGGTGACAGAAAATGAAAGTCTTTTTGGTGATTGTTAAAGCAA

>In-frame_ENST00000362074_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(amino acids)=2322AA_start in transcript=134_stop in transcript=7102
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKD
YFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEER
MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE
AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ
PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ
VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA
SWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH
DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW
QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA
AEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE
KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA
SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE
TLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK
AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ
CKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGL
CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVG
TLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKI
REGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEV
LQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESN
SNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGD
LSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRL
QAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ
LFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNF
PASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHI
DDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGES

--------------------------------------------------------------
>In-frame_ENST00000344859_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(transcript)=8137nt_BP=400nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAAGATTATTTTGCAGAGGATGATGGGGAGATGGTACCCAGAACGAGTCACA
CAGCAGCTTTTCTTAGTGACACTAAAGATCGAGGCCCTCCAGTGCAGTCACAGATCTGGAGAAGTGGTGAAAAGGTCCCGTTTGTGCAGA
CATATTCCTTGAGAGCATTTGAGAAACCCCCTCAGGTACAGACCCAGGCTCTTCGAGACTTTGAGAAGCACCTCAATGACCTGAAGAAGG
AGAACTTCAGCCTCAAGCTGCGCATCTACTTCCTGGAGGAGCGCATGCAACAGAAGTATGAGGCCAGCCGGGAGGACATCTACAAGCGGA
ACATTGAGCTGAAGGTTGAAGTGGAGAGCTTGAAACGAGAACTCCAGGACAAGAAACAGCATCTGGATAAAACATGGGCTGATGTGGAGA
ATCTCAACAGTCAGAATGAAGCTGAGCTCCGACGCCAGTTTGAGGAGCGACAGCAGGAGACGGAGCATGTTTATGAGCTCTTGGAGAATA
AGATCCAGCTTCTGCAGGAGGAATCCAGGCTAGCAAAGAATGAAGCTGCGCGGATGGCAGCTCTGGTGGAAGCAGAGAAGGAGTGTAACC
TGGAGCTCTCAGAGAAACTGAAGGGAGTCACCAAAAACTGGGAAGATGTACCAGGAGACCAGGTCAAGCCCGACCAATACACTGAGGCCC
TGGCCCAGAGGGACAAGAGAATTGAAGAACTGAATCAGAGCCTGGCTGCCCAGGAGAGGCTTGTAGAACAGCTATCTCGGGAGAAACAAC
AACTGCTACATCTGTTGGAGGAGCCAACTAGCATGGAAGTGCAGCCCATGACTGAAGAGTTGCTGAAACAACAAAAGCTGAATTCACATG
AGACCACTATAACTCAGCAGTCTGTATCTGATTCCCACTTGGCAGAACTCCAGGAAAAAATCCAGCAAACAGAGGCCACCAACAAGATTC
TTCAAGAGAAACTTAATGAAATGAGCTATGAACTAAAGTGTGCTCAGGAGTCGTCTCAAAAGCAAGATGGTACAATTCAGAACCTCAAGG
AAACTCTGAAAAGCAGGGAACGTGAGACTGAGGAGTTGTACCAGGTAATTGAAGGTCAAAATGACACAATGGCAAAGCTTCGAGAAATGC
TGCACCAAAGCCAGCTTGGACAACTTCACAGCTCAGAGGGTACTTCTCCAGCTCAGCAACAGGTAGCTCTGCTTGATCTTCAGAGTGCTT
TATTCTGCAGCCAACTTGAAATACAGAAGCTCCAGAGGGTGGTACGACAGAAAGAGCGCCAACTGGCTGATGCCAAACAATGTGTGCAAT
TTGTAGAGGCTGCAGCACACGAGAGTGAACAGCAGAAAGAGGCTTCTTGGAAACATAACCAGGAATTGCGAAAAGCCTTGCAGCAGCTAC
AAGAAGAATTGCAGAATAAGAGCCAACAGCTTCGTGCCTGGGAGGCTGAAAAATACAATGAGATTCGAACCCAGGAACAAAACATCCAGC
ACCTAAACCATAGTCTGAGTCACAAGGAGCAGTTGCTTCAGGAATTTCGGGAGCTCCTACAGTATCGAGATAACTCAGACAAAACCCTTG
AAGCAAATGAAATGTTGCTTGAGAAACTTCGCCAGCGAATACATGATAAAGCTGTTGCTCTGGAGCGGGCTATAGATGAAAAATTCTCTG
CTCTAGAAGAGAAAGAAAAAGAACTGCGCCAGCTTCGTCTTGCTGTGAGAGAGCGAGATCATGACTTAGAGAGACTGCGCGATGTCCTCT
CCTCCAATGAAGCTACTATGCAAAGTATGGAGAGTCTCCTGAGGGCCAAAGGCCTGGAAGTGGAACAGTTATCTACTACCTGTCAAAACC
TCCAGTGGCTGAAAGAAGAAATGGAAACCAAATTTAGCCGTTGGCAGAAGGAACAAGAGAGTATCATTCAGCAGTTACAGACGTCTCTTC
ATGATAGGAACAAAGAAGTGGAGGATCTTAGTGCAACACTGCTCTGCAAACTTGGACCAGGGCAGAGTGAGATAGCAGAGGAGCTGTGCC
AGCGTCTACAGCGAAAGGAAAGGATGCTGCAGGACCTTCTAAGTGATCGAAATAAACAAGTGCTGGAACATGAAATGGAGATTCAAGGCC
TGCTTCAGTCTGTGAGCACCAGGGAGCAGGAAAGCCAAGCTGCTGCAGAGAAGTTGGTGCAAGCCTTAATGGAAAGAAATTCAGAATTAC
AGGCCCTGCGCCAATATTTAGGAGGGAGAGACTCCCTGATGTCCCAAGCACCCATCTCTAACCAACAAGCTGAAGTTACCCCCACTGGCT
GTCTTGGAAAACAGACTGATCAAGGTTCAATGCAGATACCTTCCAGAGATGATAGCACTTCATTGACTGCCAAAGAGGATGTCAGCATAC
CCAGATCCACATTAGGAGACTTGGACACAGTTGCAGGGCTGGAAAAAGAACTGAGTAATGCCAAAGAGGAACTTGAACTCATGGCTAAAA
AAGAAAGAGAAAGTCAGATGGAACTTTCTGCTCTACAGTCCATGATGGCTGTGCAGGAAGAAGAGCTGCAGGTGCAGGCTGCTGATATGG
AGTCTCTGACCAGGAACATACAGATTAAAGAAGATCTCATAAAGGACCTGCAAATGCAACTGGTTGATCCTGAAGACATACCAGCTATGG
AACGCCTGACCCAGGAAGTCTTACTTCTTCGGGAAAAAGTTGCTTCAGTAGAATCCCAGGGTCAAGAAATTTCAGGAAACCGAAGACAAC
AGTTGCTGCTGATGCTAGAAGGACTAGTAGATGAACGGAGTCGGCTCAATGAGGCCTTACAAGCAGAGAGACAGCTCTATAGCAGTCTGG
TGAAGTTCCATGCCCATCCAGAGAGCTCTGAGAGAGACCGAACTCTGCAGGTGGAACTGGAAGGGGCTCAGGTGTTACGCAGTCGGCTAG
AAGAAGTTCTTGGAAGAAGCTTGGAGCGCTTAAACAGGCTGGAGACCCTGGCCGCCATTGGAGGTGCAGCTGCAGGGGATGACACCGAAG
ATACAAGCACTGAGTTCACTGACAGTATTGAGGAGGAGGCTGCACACCATAGTCACCAGCAACTTGTCAAGGTGGCTTTGGAGAAAAGTC
TGGCAACTGTGGAGACCCAGAACCCATCTTTTTCCCCTCCTTCTCCGATGGGAGGGGACAGTAACAGGTGTCTTCAGGAAGAAATGCTCC
ACCTGAGGGCTGAGTTCCACCAGCACTTAGAAGAGAAGAGGAAAGCTGAGGAGGAACTGAAGGAGCTAAAGGCTCAAATTGAGGAAGCAG
GATTCTCCTCAGTGTCCCACATCAGGAACACCATGCTGAGCCTTTGCCTTGAGAATGCGGAGCTGAAAGAGCAGATGGGAGAAGCAATGT
CTGATGGATGGGAGATCGAGGAAGACAAGGAGAAGGGCGAGTTGGATAACCAGTCCCAGCCTCGTGACCCTGGGCCTCAGTCAGCGTTTA
GCCTACCAGGGTCCACCCAGCACCTGCGCTCCCAGCTGTCACAATGCAAACAACGCTATCAAGATCTCCAGGAGAAGCTGCTGCTATCAG
AAGCCACTGTCTTTGCTCAGGCTAACGAGCTGGAGAAATACAGAGTTATGCTTACAGGTGAATCCTTGGTGAAGCAGGACAGCAAGCAGA
TCCAGGTGGACCTCCAGGACCTGGGCTATGAGACTTGTGGCCGAAGCGAGAATGAGGCTGAACGGGAGGAAACCACCAGTCCTGAGTGTG
AGGAGCACAACAGCCTCAAGGAAATGGTCCTGATGGAGGGGCTGTGCTCTGAGCAGGGACGCCGGGGCTCAACACTGGCTAGTTCCTCTG
AGAGGAAGCCCTTGGAGAACCAGCTAGGGAAGCAGGAAGAGTTCCGGGTATATGGAAAGTCAGAAAACATCTTGGTCCTACGAAAGGACA
TCAAAGATCTGAAGGCCCAGCTGCAGAATGCCAACAAGGTCATTCAAAACCTCAAGAGCCGGGTCCGGTCCCTCTCAGTTACAAGTGATT
ATTCGTCTAGTCTGGAAAGACCCTGGAAGCTGAGAGCTGTTGGCACCTTGGAGGGGTCTTCACCTCATAGTGTCCCTGATGAGGATGAGG
GGTGGCTGTCTGATGGCACTGGGGCTTTCTACTCTCCAGGGCTTCAGGCCAAAAAGGACCTGGAGAGTCTCATCCAGAGAGTATCCCAGC
TGGAGGCCCAGCTCCCAAAAAATGGACTAGAAGAGAAGCTGGCTGAGGAGCTGAGATCAGCCTCGTGGCCTGGGAAATATGATTCCCTGA
TTCAGGATCAGGCCCGGGAACTGTCTTACCTACGGCAAAAAATACGAGAAGGGAGAGGTATTTGTTATCTTATCACCCGGCATGCAAAAG
ATACAGTAAAATCTTTTGAGGATCTCCTAAGGAGCAATGACATTGACTACTACCTGGGACAGAGCTTCCGGGAGCAACTCGCCCAGGGAA
GCCAGCTGACAGAGAGGCTCACCAGCAAACTCAGCACCAAGGATCATAAAAGTGAGAAAGATCAAGCTGGACTTGAGCCACTGGCCCTCA
GGCTCAGCAGGGAGCTGCAGGAGAAGGAGAAAGTGATTGAAGTCCTGCAGGCCAAGCTGGATGCTCGGTCCCTCACACCCTCCAGCAGCC
ATGCCTTGTCTGACTCCCACCGCTCTCCCAGCAGCACCTCTTTCCTGTCTGATGAACTGGAAGCCTGCTCTGACATGGACATAGTCAGCG
AGTACACACACTATGAAGAGAAGAAAGCTTCTCCCAGTCACTCAGATTCCATCCATCATTCGAGTCATTCTGCTGTGTTGTCTTCTAAAC
CATCATCAACCAGTGCATCTCAGGGGGCTAAGGCCGAATCCAACAGCAACCCCATCAGCTTGCCAACTCCCCAGAATACCCCCAAGGAGG
CCAACCAGGCCCATTCAGGTGCCAGCACTGTTCCTCCTGCTTCCACAGCTACATTGCTGAGCAACGACTTGGAAGCCGACTCTTCCTACT
ACCTCAACTCTGCCCAGCCTCACTCTCCTCCAAGGGGCACCATAGAACTGGGAAGAATCCTAGAGCCTGGGTACCTGGGCAGCAGTGGCA
AGTGGGATGTGATGAGGCCTCAGAAAGGGAGTGTATCTGGGGACCTATCCTCAGGCTCCTCTGTGTACCAGCTTAACTCCAAACCCACAG
GGGCTGACCTGCTGGAAGAGCATCTTGGTGAAATCCGGAACCTGCGCCAGCGCCTGGAGGAATCCATCTGCATCAATGACCGCCTACGGG
AGCAACTGGAACACCGGCTGACCTCTACTGCTCGTGGAAGGGGATCCACTTCTAACTTCTACAGTCAGGGCCTGGAGTCCATACCTCAGC
TCTGCAATGAGAACAGAGTCCTCAGGGAAGACAATCGAAGACTTCAGGCTCAACTGAGTCATGTTTCCAGAGAGCACTCCCAGGAAACAG
AAAGCCTGAGGGAGGCTCTGCTGTCCTCTCGATCCCACCTTCAAGAGCTGGAAAAGGAGCTGGAGCACCAGAAGGTGGAAAGGCAGCAGC
TTTTGGAAGACTTGAGGGAGAAGCAGCAAGAGGTCTTGCATTTCAGGGAGGAACGTCTTTCCCTCCAGGAAAACGACTCCAGACTGCAGC
ACAAGCTGGTTCTCCTGCAGCAACAGTGTGAAGAGAAACAGCAGCTCTTTGAGTCCCTCCAGTCAGAGCTACAAATCTACGAGGCACTTT
ATGGCAATTCCAAGAAGGGGCTGAAAGCTTACAGCCTGGATGCCTGTCACCAAATCCCTTTGAGCAGTGACCTGAGCCACCTGGTGGCAG
AGGTACGAGCTCTGAGAGGGCAGCTGGAGCAGAGCATTCAGGGGAACAATTGTCTGCGACTGCAGCTGCAACAGCAGCTGGAGAGCGGTG
CTGGCAAAGCCAGCCTCAGCCCCTCCTCCATTAACCAGAACTTCCCAGCCAGCACTGACCCTGGAAACAAGCAGCTGCTCCTCCAAGATT
CAGCTGTGTCCCCTCCAGTCCGGGATGTTGGTATGAATTCCCCAGCTCTGGTCTTCCCCAGCTCTGCTTCCTCTACTCCTGGCTCAGAAA
CGCCCATAATCAACAGAGCAAATGGCTTGGGTTTGGATACTTCTCCAGTAATGAAGACCCCTCCCAAGCTAGAGGGTGATGCTACTGATG
GCTCCTTTGCCAATAAGCATGGCCGCCATGTCATTGGCCACATTGATGACTACAGTGCCCTAAGACAGCAGATTGCGGAGGGCAAGCTGC
TGGTCAAAAAGATAGTGTCTCTTGTGAGATCAGCGTGCAGCTTCCCTGGCCTTGAAGCCCAAGGCACAGAGGTGCTAGGCAGCAAAGGTA
TTCATGAGCTTCGGAGCAGCACCAGTGCCCTGCACCATGCCCTAGAGGAGTCAGCTTCCCTCCTCACCATGTTCTGGAGAGCGGCCCTGC
CAAGCACCCACATCCCTGTGCTGCCTGGCAAAGTGGGAGAATCAACAGAAAGGGAACTTCTGGAACTGAGAACCAAAGTATCCAAACAGG
AGCGACTCCTTCAGAGCACAACTGAGCATCTGAAGAACGCCAACCAGCAGAAGGAGAGCATGGAACAGTTCATTGTCAGCCAGCTAACCA
GAACACATGATGTTTTAAAGAAGGCAAGGACTAACTTAGAGGTGAAATCCCTAAGGGCTCTGCCATGTACTCCAGCCTTGTGACCCTTGC
CTTCCAGGAACCATGCAAGAAGCGCAGCCACCAGAAGTCCTTAAAACAGCAGGAAAGGTGGGCCTGTCCCCCTTTTGTGCAGCTACCTAT
CTGCTGAGGAGCATCTGGGCCTCATTCCTCCAAGTCCACGGGAGGGTCCAGAAGAGGGAGTCAGAGATGTATCCTGGTGGAGCTGGGAGA
AAGGCAGAAAGCCTTTCTGACGGCTATGGAATACGATTAGCCAAGGTCCACTTGGCCCAGCACTAAGAAAAAGATGCGTAGTTTGCACAG
AAGGTTTTGTGATCCTGCCTCTCAACAGCCCCAGCAGCTTGGGAACTAGCAAGAGCACATTTCTTGCCTCATCAGCTGTCCTGAGATGGA
AAACTCAGTGAATATAGGACCCTGATTCCGATGAAAGGGGCACGTGGTCCCAATGCTGGAGCTCCTCTGGCAGGTTCTAAAAGCACACTA
CTGAGCAGCGGTGCCCTGCCGGACACTGCTGGCGGGGGCTCAGTGAGCACTACTCACAGATCCACACCTGACCCTGTTGGGTCGAGTCAG
GCTGGGCCTTGGTCTGCACTGTAGCACCTGTGTTCTTTGAGTTCACATCATGAATGTGGTGACTTCCCAGATACCATCTCAGGCTTAACC
TAGCACATCCTATTTCTTTTCTTCTATGATATCCAAATTGGACTGACCTCACTTCAAAGTTGCTGTCCCATTTTGTCACCCTATCTTATC
TCGGGGAAATTGCAGACTGATGGCCAGACCAACTCTGTTGAAATTCTTGCATAGAGCAAACCTGTGCTCATTTTTAAGTGGCATGGGAGA
GGCCCCAAGCCTAGTAAAGCCTAGTCTGTGTCTTCACAGTGCTGGTAGAATGTGTTTGTGTGTATAAATATATGATATAGATTTATATAT
GTTGCTAACGCCATATATTGAAGGCCAACATAACTGGTGGACAGGGTGGGTGACAGAAAATGAAAGTCTTTTTGGTGATTGTTAAAGCAA

>In-frame_ENST00000344859_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(amino acids)=2322AA_start in transcript=134_stop in transcript=7102
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKD
YFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEER
MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE
AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ
PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ
VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA
SWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH
DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW
QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA
AEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE
KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA
SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE
TLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK
AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ
CKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGL
CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVG
TLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKI
REGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEV
LQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESN
SNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGD
LSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRL
QAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ
LFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNF
PASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHI
DDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGES

--------------------------------------------------------------
>In-frame_ENST00000369340_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(transcript)=8219nt_BP=482nt
ACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTCAATAGTTGAATGTTGAAGGAGAGGATGCCAAG
GGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAATG
CCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCCAC
TTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGACACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTCCA
CCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCGTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGT
GTTACCTACCACAATGGCACAGGATACTGCAAAGATTATTTTGCAGAGGATGATGGGGAGATGGTACCCAGAACGAGTCACACAGCAGCT
TTTCTTAGTGACACTAAAGATCGAGGCCCTCCAGTGCAGTCACAGATCTGGAGAAGTGGTGAAAAGGTCCCGTTTGTGCAGACATATTCC
TTGAGAGCATTTGAGAAACCCCCTCAGGTACAGACCCAGGCTCTTCGAGACTTTGAGAAGCACCTCAATGACCTGAAGAAGGAGAACTTC
AGCCTCAAGCTGCGCATCTACTTCCTGGAGGAGCGCATGCAACAGAAGTATGAGGCCAGCCGGGAGGACATCTACAAGCGGAACATTGAG
CTGAAGGTTGAAGTGGAGAGCTTGAAACGAGAACTCCAGGACAAGAAACAGCATCTGGATAAAACATGGGCTGATGTGGAGAATCTCAAC
AGTCAGAATGAAGCTGAGCTCCGACGCCAGTTTGAGGAGCGACAGCAGGAGACGGAGCATGTTTATGAGCTCTTGGAGAATAAGATCCAG
CTTCTGCAGGAGGAATCCAGGCTAGCAAAGAATGAAGCTGCGCGGATGGCAGCTCTGGTGGAAGCAGAGAAGGAGTGTAACCTGGAGCTC
TCAGAGAAACTGAAGGGAGTCACCAAAAACTGGGAAGATGTACCAGGAGACCAGGTCAAGCCCGACCAATACACTGAGGCCCTGGCCCAG
AGGGACAAGAGAATTGAAGAACTGAATCAGAGCCTGGCTGCCCAGGAGAGGCTTGTAGAACAGCTATCTCGGGAGAAACAACAACTGCTA
CATCTGTTGGAGGAGCCAACTAGCATGGAAGTGCAGCCCATGACTGAAGAGTTGCTGAAACAACAAAAGCTGAATTCACATGAGACCACT
ATAACTCAGCAGTCTGTATCTGATTCCCACTTGGCAGAACTCCAGGAAAAAATCCAGCAAACAGAGGCCACCAACAAGATTCTTCAAGAG
AAACTTAATGAAATGAGCTATGAACTAAAGTGTGCTCAGGAGTCGTCTCAAAAGCAAGATGGTACAATTCAGAACCTCAAGGAAACTCTG
AAAAGCAGGGAACGTGAGACTGAGGAGTTGTACCAGGTAATTGAAGGTCAAAATGACACAATGGCAAAGCTTCGAGAAATGCTGCACCAA
AGCCAGCTTGGACAACTTCACAGCTCAGAGGGTACTTCTCCAGCTCAGCAACAGGTAGCTCTGCTTGATCTTCAGAGTGCTTTATTCTGC
AGCCAACTTGAAATACAGAAGCTCCAGAGGGTGGTACGACAGAAAGAGCGCCAACTGGCTGATGCCAAACAATGTGTGCAATTTGTAGAG
GCTGCAGCACACGAGAGTGAACAGCAGAAAGAGGCTTCTTGGAAACATAACCAGGAATTGCGAAAAGCCTTGCAGCAGCTACAAGAAGAA
TTGCAGAATAAGAGCCAACAGCTTCGTGCCTGGGAGGCTGAAAAATACAATGAGATTCGAACCCAGGAACAAAACATCCAGCACCTAAAC
CATAGTCTGAGTCACAAGGAGCAGTTGCTTCAGGAATTTCGGGAGCTCCTACAGTATCGAGATAACTCAGACAAAACCCTTGAAGCAAAT
GAAATGTTGCTTGAGAAACTTCGCCAGCGAATACATGATAAAGCTGTTGCTCTGGAGCGGGCTATAGATGAAAAATTCTCTGCTCTAGAA
GAGAAAGAAAAAGAACTGCGCCAGCTTCGTCTTGCTGTGAGAGAGCGAGATCATGACTTAGAGAGACTGCGCGATGTCCTCTCCTCCAAT
GAAGCTACTATGCAAAGTATGGAGAGTCTCCTGAGGGCCAAAGGCCTGGAAGTGGAACAGTTATCTACTACCTGTCAAAACCTCCAGTGG
CTGAAAGAAGAAATGGAAACCAAATTTAGCCGTTGGCAGAAGGAACAAGAGAGTATCATTCAGCAGTTACAGACGTCTCTTCATGATAGG
AACAAAGAAGTGGAGGATCTTAGTGCAACACTGCTCTGCAAACTTGGACCAGGGCAGAGTGAGATAGCAGAGGAGCTGTGCCAGCGTCTA
CAGCGAAAGGAAAGGATGCTGCAGGACCTTCTAAGTGATCGAAATAAACAAGTGCTGGAACATGAAATGGAGATTCAAGGCCTGCTTCAG
TCTGTGAGCACCAGGGAGCAGGAAAGCCAAGCTGCTGCAGAGAAGTTGGTGCAAGCCTTAATGGAAAGAAATTCAGAATTACAGGCCCTG
CGCCAATATTTAGGAGGGAGAGACTCCCTGATGTCCCAAGCACCCATCTCTAACCAACAAGCTGAAGTTACCCCCACTGGCTGTCTTGGA
AAACAGACTGATCAAGGTTCAATGCAGATACCTTCCAGAGATGATAGCACTTCATTGACTGCCAAAGAGGATGTCAGCATACCCAGATCC
ACATTAGGAGACTTGGACACAGTTGCAGGGCTGGAAAAAGAACTGAGTAATGCCAAAGAGGAACTTGAACTCATGGCTAAAAAAGAAAGA
GAAAGTCAGATGGAACTTTCTGCTCTACAGTCCATGATGGCTGTGCAGGAAGAAGAGCTGCAGGTGCAGGCTGCTGATATGGAGTCTCTG
ACCAGGAACATACAGATTAAAGAAGATCTCATAAAGGACCTGCAAATGCAACTGGTTGATCCTGAAGACATACCAGCTATGGAACGCCTG
ACCCAGGAAGTCTTACTTCTTCGGGAAAAAGTTGCTTCAGTAGAATCCCAGGGTCAAGAAATTTCAGGAAACCGAAGACAACAGTTGCTG
CTGATGCTAGAAGGACTAGTAGATGAACGGAGTCGGCTCAATGAGGCCTTACAAGCAGAGAGACAGCTCTATAGCAGTCTGGTGAAGTTC
CATGCCCATCCAGAGAGCTCTGAGAGAGACCGAACTCTGCAGGTGGAACTGGAAGGGGCTCAGGTGTTACGCAGTCGGCTAGAAGAAGTT
CTTGGAAGAAGCTTGGAGCGCTTAAACAGGCTGGAGACCCTGGCCGCCATTGGAGGTGCAGCTGCAGGGGATGACACCGAAGATACAAGC
ACTGAGTTCACTGACAGTATTGAGGAGGAGGCTGCACACCATAGTCACCAGCAACTTGTCAAGGTGGCTTTGGAGAAAAGTCTGGCAACT
GTGGAGACCCAGAACCCATCTTTTTCCCCTCCTTCTCCGATGGGAGGGGACAGTAACAGGTGTCTTCAGGAAGAAATGCTCCACCTGAGG
GCTGAGTTCCACCAGCACTTAGAAGAGAAGAGGAAAGCTGAGGAGGAACTGAAGGAGCTAAAGGCTCAAATTGAGGAAGCAGGATTCTCC
TCAGTGTCCCACATCAGGAACACCATGCTGAGCCTTTGCCTTGAGAATGCGGAGCTGAAAGAGCAGATGGGAGAAGCAATGTCTGATGGA
TGGGAGATCGAGGAAGACAAGGAGAAGGGCGAGTTGGATAACCAGTCCCAGCCTCGTGACCCTGGGCCTCAGTCAGCGTTTAGCCTACCA
GGGTCCACCCAGCACCTGCGCTCCCAGCTGTCACAATGCAAACAACGCTATCAAGATCTCCAGGAGAAGCTGCTGCTATCAGAAGCCACT
GTCTTTGCTCAGGCTAACGAGCTGGAGAAATACAGAGTTATGCTTACAGGTGAATCCTTGGTGAAGCAGGACAGCAAGCAGATCCAGGTG
GACCTCCAGGACCTGGGCTATGAGACTTGTGGCCGAAGCGAGAATGAGGCTGAACGGGAGGAAACCACCAGTCCTGAGTGTGAGGAGCAC
AACAGCCTCAAGGAAATGGTCCTGATGGAGGGGCTGTGCTCTGAGCAGGGACGCCGGGGCTCAACACTGGCTAGTTCCTCTGAGAGGAAG
CCCTTGGAGAACCAGCTAGGGAAGCAGGAAGAGTTCCGGGTATATGGAAAGTCAGAAAACATCTTGGTCCTACGAAAGGACATCAAAGAT
CTGAAGGCCCAGCTGCAGAATGCCAACAAGGTCATTCAAAACCTCAAGAGCCGGGTCCGGTCCCTCTCAGTTACAAGTGATTATTCGTCT
AGTCTGGAAAGACCCTGGAAGCTGAGAGCTGTTGGCACCTTGGAGGGGTCTTCACCTCATAGTGTCCCTGATGAGGATGAGGGGTGGCTG
TCTGATGGCACTGGGGCTTTCTACTCTCCAGGGCTTCAGGCCAAAAAGGACCTGGAGAGTCTCATCCAGAGAGTATCCCAGCTGGAGGCC
CAGCTCCCAAAAAATGGACTAGAAGAGAAGCTGGCTGAGGAGCTGAGATCAGCCTCGTGGCCTGGGAAATATGATTCCCTGATTCAGGAT
CAGGCCCGGGAACTGTCTTACCTACGGCAAAAAATACGAGAAGGGAGAGGTATTTGTTATCTTATCACCCGGCATGCAAAAGATACAGTA
AAATCTTTTGAGGATCTCCTAAGGAGCAATGACATTGACTACTACCTGGGACAGAGCTTCCGGGAGCAACTCGCCCAGGGAAGCCAGCTG
ACAGAGAGGCTCACCAGCAAACTCAGCACCAAGGATCATAAAAGTGAGAAAGATCAAGCTGGACTTGAGCCACTGGCCCTCAGGCTCAGC
AGGGAGCTGCAGGAGAAGGAGAAAGTGATTGAAGTCCTGCAGGCCAAGCTGGATGCTCGGTCCCTCACACCCTCCAGCAGCCATGCCTTG
TCTGACTCCCACCGCTCTCCCAGCAGCACCTCTTTCCTGTCTGATGAACTGGAAGCCTGCTCTGACATGGACATAGTCAGCGAGTACACA
CACTATGAAGAGAAGAAAGCTTCTCCCAGTCACTCAGATTCCATCCATCATTCGAGTCATTCTGCTGTGTTGTCTTCTAAACCATCATCA
ACCAGTGCATCTCAGGGGGCTAAGGCCGAATCCAACAGCAACCCCATCAGCTTGCCAACTCCCCAGAATACCCCCAAGGAGGCCAACCAG
GCCCATTCAGGTGCCAGCACTGTTCCTCCTGCTTCCACAGCTACATTGCTGAGCAACGACTTGGAAGCCGACTCTTCCTACTACCTCAAC
TCTGCCCAGCCTCACTCTCCTCCAAGGGGCACCATAGAACTGGGAAGAATCCTAGAGCCTGGGTACCTGGGCAGCAGTGGCAAGTGGGAT
GTGATGAGGCCTCAGAAAGGGAGTGTATCTGGGGACCTATCCTCAGGCTCCTCTGTGTACCAGCTTAACTCCAAACCCACAGGGGCTGAC
CTGCTGGAAGAGCATCTTGGTGAAATCCGGAACCTGCGCCAGCGCCTGGAGGAATCCATCTGCATCAATGACCGCCTACGGGAGCAACTG
GAACACCGGCTGACCTCTACTGCTCGTGGAAGGGGATCCACTTCTAACTTCTACAGTCAGGGCCTGGAGTCCATACCTCAGCTCTGCAAT
GAGAACAGAGTCCTCAGGGAAGACAATCGAAGACTTCAGGCTCAACTGAGTCATGTTTCCAGAGAGCACTCCCAGGAAACAGAAAGCCTG
AGGGAGGCTCTGCTGTCCTCTCGATCCCACCTTCAAGAGCTGGAAAAGGAGCTGGAGCACCAGAAGGTGGAAAGGCAGCAGCTTTTGGAA
GACTTGAGGGAGAAGCAGCAAGAGGTCTTGCATTTCAGGGAGGAACGTCTTTCCCTCCAGGAAAACGACTCCAGACTGCAGCACAAGCTG
GTTCTCCTGCAGCAACAGTGTGAAGAGAAACAGCAGCTCTTTGAGTCCCTCCAGTCAGAGCTACAAATCTACGAGGCACTTTATGGCAAT
TCCAAGAAGGGGCTGAAAGCTTACAGCCTGGATGCCTGTCACCAAATCCCTTTGAGCAGTGACCTGAGCCACCTGGTGGCAGAGGTACGA
GCTCTGAGAGGGCAGCTGGAGCAGAGCATTCAGGGGAACAATTGTCTGCGACTGCAGCTGCAACAGCAGCTGGAGAGCGGTGCTGGCAAA
GCCAGCCTCAGCCCCTCCTCCATTAACCAGAACTTCCCAGCCAGCACTGACCCTGGAAACAAGCAGCTGCTCCTCCAAGATTCAGCTGTG
TCCCCTCCAGTCCGGGATGTTGGTATGAATTCCCCAGCTCTGGTCTTCCCCAGCTCTGCTTCCTCTACTCCTGGCTCAGAAACGCCCATA
ATCAACAGAGCAAATGGCTTGGGTTTGGATACTTCTCCAGTAATGAAGACCCCTCCCAAGCTAGAGGGTGATGCTACTGATGGCTCCTTT
GCCAATAAGCATGGCCGCCATGTCATTGGCCACATTGATGACTACAGTGCCCTAAGACAGCAGATTGCGGAGGGCAAGCTGCTGGTCAAA
AAGATAGTGTCTCTTGTGAGATCAGCGTGCAGCTTCCCTGGCCTTGAAGCCCAAGGCACAGAGGTGCTAGGCAGCAAAGGTATTCATGAG
CTTCGGAGCAGCACCAGTGCCCTGCACCATGCCCTAGAGGAGTCAGCTTCCCTCCTCACCATGTTCTGGAGAGCGGCCCTGCCAAGCACC
CACATCCCTGTGCTGCCTGGCAAAGTGGGAGAATCAACAGAAAGGGAACTTCTGGAACTGAGAACCAAAGTATCCAAACAGGAGCGACTC
CTTCAGAGCACAACTGAGCATCTGAAGAACGCCAACCAGCAGAAGGAGAGCATGGAACAGTTCATTGTCAGCCAGCTAACCAGAACACAT
GATGTTTTAAAGAAGGCAAGGACTAACTTAGAGGTGAAATCCCTAAGGGCTCTGCCATGTACTCCAGCCTTGTGACCCTTGCCTTCCAGG
AACCATGCAAGAAGCGCAGCCACCAGAAGTCCTTAAAACAGCAGGAAAGGTGGGCCTGTCCCCCTTTTGTGCAGCTACCTATCTGCTGAG
GAGCATCTGGGCCTCATTCCTCCAAGTCCACGGGAGGGTCCAGAAGAGGGAGTCAGAGATGTATCCTGGTGGAGCTGGGAGAAAGGCAGA
AAGCCTTTCTGACGGCTATGGAATACGATTAGCCAAGGTCCACTTGGCCCAGCACTAAGAAAAAGATGCGTAGTTTGCACAGAAGGTTTT
GTGATCCTGCCTCTCAACAGCCCCAGCAGCTTGGGAACTAGCAAGAGCACATTTCTTGCCTCATCAGCTGTCCTGAGATGGAAAACTCAG
TGAATATAGGACCCTGATTCCGATGAAAGGGGCACGTGGTCCCAATGCTGGAGCTCCTCTGGCAGGTTCTAAAAGCACACTACTGAGCAG
CGGTGCCCTGCCGGACACTGCTGGCGGGGGCTCAGTGAGCACTACTCACAGATCCACACCTGACCCTGTTGGGTCGAGTCAGGCTGGGCC
TTGGTCTGCACTGTAGCACCTGTGTTCTTTGAGTTCACATCATGAATGTGGTGACTTCCCAGATACCATCTCAGGCTTAACCTAGCACAT
CCTATTTCTTTTCTTCTATGATATCCAAATTGGACTGACCTCACTTCAAAGTTGCTGTCCCATTTTGTCACCCTATCTTATCTCGGGGAA
ATTGCAGACTGATGGCCAGACCAACTCTGTTGAAATTCTTGCATAGAGCAAACCTGTGCTCATTTTTAAGTGGCATGGGAGAGGCCCCAA
GCCTAGTAAAGCCTAGTCTGTGTCTTCACAGTGCTGGTAGAATGTGTTTGTGTGTATAAATATATGATATAGATTTATATATGTTGCTAA
CGCCATATATTGAAGGCCAACATAACTGGTGGACAGGGTGGGTGACAGAAAATGAAAGTCTTTTTGGTGATTGTTAAAGCAAGATGTGTA

>In-frame_ENST00000369340_ENST00000313382_TCGA-EJ-5527_NOTCH2NL_chr1_145248894_+_PDE4DIP_chr1_145021167_length(amino acids)=2260AA_start in transcript=402_stop in transcript=7184
MQCRDGYEPCVNEGMCVTYHNGTGYCKDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQA
LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER
QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA
QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQE
SSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ
KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR
ELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK
GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR
NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRD
DSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDL
QMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQ
VELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPM
GGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDN
QSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSE
NEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQN
LKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEE
LRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHK
SEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDS
IHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIEL
GRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGST
SNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE
ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNN
CLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPV
MKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEE
SASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKS

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Fusion Gene PPI Analysis for NOTCH2NL-PDE4DIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOTCH2NL-PDE4DIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOTCH2NL-PDE4DIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource