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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NPEPPS-KPNB1 (FusionGDB2 ID:59523) |
Fusion Gene Summary for NPEPPS-KPNB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPEPPS-KPNB1 | Fusion gene ID: 59523 | Hgene | Tgene | Gene symbol | NPEPPS | KPNB1 | Gene ID | 9520 | 3837 |
| Gene name | aminopeptidase puromycin sensitive | karyopherin subunit beta 1 | |
| Synonyms | AAP-S|MP100|PSA | IMB1|IPO1|IPOB|Impnb|NTF97 | |
| Cytomap | 17q21.32 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100 | importin subunit beta-1PTAC97importin 1importin 90importin beta-1 subunitkaryopherin (importin) beta 1nuclear factor p97pore targeting complex 97 kDa subunit | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P55786 | Q14974 | |
| Ensembl transtripts involved in fusion gene | ENST00000525037, ENST00000530173, ENST00000322157, ENST00000544660, | ENST00000535458, ENST00000290158, ENST00000540627, ENST00000537679, ENST00000577918, | |
| Fusion gene scores | * DoF score | 18 X 9 X 9=1458 | 14 X 17 X 8=1904 |
| # samples | 19 | 17 | |
| ** MAII score | log2(19/1458*10)=-2.93991939599599 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1904*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NPEPPS [Title/Abstract] AND KPNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NPEPPS(45608921)-KPNB1(45740455), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NPEPPS | GO:0071456 | cellular response to hypoxia | 21056661 |
| Tgene | KPNB1 | GO:0006606 | protein import into nucleus | 7615630|15964792 |
| Tgene | KPNB1 | GO:0006610 | ribosomal protein import into nucleus | 9687515 |
| Fusion gene breakpoints across NPEPPS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KPNB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-78-8648-01A | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| ChimerDB4 | LUAD | TCGA-78-8648-01A | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
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Fusion Gene ORF analysis for NPEPPS-KPNB1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000525037 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| intron-3CDS | ENST00000525037 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| intron-3CDS | ENST00000525037 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| intron-3CDS | ENST00000525037 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| intron-intron | ENST00000525037 | ENST00000577918 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000530173 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000530173 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000530173 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000530173 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| 5CDS-intron | ENST00000530173 | ENST00000577918 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000322157 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000322157 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000322157 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000322157 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| 5CDS-intron | ENST00000322157 | ENST00000577918 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000544660 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000544660 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000544660 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| In-frame | ENST00000544660 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| 5CDS-intron | ENST00000544660 | ENST00000577918 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000530173 | NPEPPS | chr17 | 45608921 | + | ENST00000535458 | KPNB1 | chr17 | 45740455 | + | 2437 | 273 | 30 | 2207 | 725 |
| ENST00000530173 | NPEPPS | chr17 | 45608921 | + | ENST00000290158 | KPNB1 | chr17 | 45740455 | + | 5309 | 273 | 30 | 2207 | 725 |
| ENST00000530173 | NPEPPS | chr17 | 45608921 | + | ENST00000540627 | KPNB1 | chr17 | 45740455 | + | 2484 | 273 | 30 | 2207 | 725 |
| ENST00000530173 | NPEPPS | chr17 | 45608921 | + | ENST00000537679 | KPNB1 | chr17 | 45740455 | + | 2271 | 273 | 30 | 1994 | 654 |
| ENST00000322157 | NPEPPS | chr17 | 45608921 | + | ENST00000535458 | KPNB1 | chr17 | 45740455 | + | 2656 | 492 | 66 | 2426 | 786 |
| ENST00000322157 | NPEPPS | chr17 | 45608921 | + | ENST00000290158 | KPNB1 | chr17 | 45740455 | + | 5528 | 492 | 66 | 2426 | 786 |
| ENST00000322157 | NPEPPS | chr17 | 45608921 | + | ENST00000540627 | KPNB1 | chr17 | 45740455 | + | 2703 | 492 | 66 | 2426 | 786 |
| ENST00000322157 | NPEPPS | chr17 | 45608921 | + | ENST00000537679 | KPNB1 | chr17 | 45740455 | + | 2490 | 492 | 66 | 2213 | 715 |
| ENST00000544660 | NPEPPS | chr17 | 45608921 | + | ENST00000535458 | KPNB1 | chr17 | 45740455 | + | 2393 | 229 | 13 | 2163 | 716 |
| ENST00000544660 | NPEPPS | chr17 | 45608921 | + | ENST00000290158 | KPNB1 | chr17 | 45740455 | + | 5265 | 229 | 13 | 2163 | 716 |
| ENST00000544660 | NPEPPS | chr17 | 45608921 | + | ENST00000540627 | KPNB1 | chr17 | 45740455 | + | 2440 | 229 | 13 | 2163 | 716 |
| ENST00000544660 | NPEPPS | chr17 | 45608921 | + | ENST00000537679 | KPNB1 | chr17 | 45740455 | + | 2227 | 229 | 13 | 1950 | 645 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000530173 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.007363902 | 0.99263614 |
| ENST00000530173 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.001281892 | 0.99871814 |
| ENST00000530173 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.006427585 | 0.9935725 |
| ENST00000530173 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.003947198 | 0.99605274 |
| ENST00000322157 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.003817305 | 0.9961826 |
| ENST00000322157 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.000495692 | 0.9995043 |
| ENST00000322157 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.003354763 | 0.99664515 |
| ENST00000322157 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.002911541 | 0.9970885 |
| ENST00000544660 | ENST00000535458 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.00397465 | 0.9960253 |
| ENST00000544660 | ENST00000290158 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.000652516 | 0.9993475 |
| ENST00000544660 | ENST00000540627 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.003509845 | 0.9964902 |
| ENST00000544660 | ENST00000537679 | NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740455 | + | 0.003306757 | 0.99669325 |
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Fusion Genomic Features for NPEPPS-KPNB1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740454 | + | 2.58E-08 | 1 |
| NPEPPS | chr17 | 45608921 | + | KPNB1 | chr17 | 45740454 | + | 2.58E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NPEPPS-KPNB1 |
| Go to FGviewer for the breakpoints of chr17:45608921-chr17:45740455 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPEPPS | KPNB1 |
| FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}. | FUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:9687515}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 337_341 | 232.0 | 877.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 329_342 | 232.0 | 877.0 | Region | Note=IAB-binding | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 334_419 | 232.0 | 877.0 | Region | Note=Ran-GTP binding | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 253_302 | 232.0 | 877.0 | Repeat | HEAT 7 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 314_360 | 232.0 | 877.0 | Repeat | HEAT 8 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 364_394 | 232.0 | 877.0 | Repeat | HEAT 9 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 402_438 | 232.0 | 877.0 | Repeat | HEAT 10 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 449_485 | 232.0 | 877.0 | Repeat | HEAT 11 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 500_537 | 232.0 | 877.0 | Repeat | HEAT 12 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 544_592 | 232.0 | 877.0 | Repeat | HEAT 13 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 600_639 | 232.0 | 877.0 | Repeat | HEAT 14 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 644_681 | 232.0 | 877.0 | Repeat | HEAT 15 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 686_724 | 232.0 | 877.0 | Repeat | HEAT 16 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 732_776 | 232.0 | 877.0 | Repeat | HEAT 17 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 786_829 | 232.0 | 877.0 | Repeat | HEAT 18 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 831_873 | 232.0 | 877.0 | Repeat | HEAT 19 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NPEPPS | chr17:45608921 | chr17:45740455 | ENST00000322157 | + | 1 | 23 | 726_730 | 85.0 | 920.0 | Motif | Nuclear localization signal |
| Hgene | NPEPPS | chr17:45608921 | chr17:45740455 | ENST00000322157 | + | 1 | 23 | 316_320 | 85.0 | 920.0 | Region | Substrate binding |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 21_101 | 232.0 | 877.0 | Domain | Importin N-terminal | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 129_160 | 232.0 | 877.0 | Repeat | HEAT 4 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 170_202 | 232.0 | 877.0 | Repeat | HEAT 5 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 212_247 | 232.0 | 877.0 | Repeat | HEAT 6 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 2_31 | 232.0 | 877.0 | Repeat | HEAT 1 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 33_65 | 232.0 | 877.0 | Repeat | HEAT 2 | |
| Tgene | KPNB1 | chr17:45608921 | chr17:45740455 | ENST00000290158 | 5 | 22 | 85_123 | 232.0 | 877.0 | Repeat | HEAT 3 |
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Fusion Gene Sequence for NPEPPS-KPNB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000530173_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2437nt_BP=273nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTT GCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATG GATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTAT CTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGC CTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGG TACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCC ACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAA GCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGC TGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCT TCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCT CTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTT CTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTT CTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCT GGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAA CCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTG CAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCG CAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAG GCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGA ATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATT GACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAG GATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTT GCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAA ATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAA ACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGA >In-frame_ENST00000530173_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=725AA_start in transcript=30_stop in transcript=2207 MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNL VKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLT KQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPS VVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLL ETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDAL QISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDE VMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQE NVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRK -------------------------------------------------------------- >In-frame_ENST00000530173_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=5309nt_BP=273nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTT GCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATG GATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTAT CTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGC CTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGG TACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCC ACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAA GCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGC TGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCT TCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCT CTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTT CTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTT CTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCT GGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAA CCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTG CAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCG CAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAG GCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGA ATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATT GACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAG GATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTT GCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAA ATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAA ACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGA AAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAGTTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGA GGCTAGAAGTAGCTTTTCTGTCTTTTGGCCAGTGCCGAGTGGAATGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCT TTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGG TACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGAGAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTTTCA ACTTCAAGTCATTGCAGTTTCTTTTTCCCAGAAAACAAGGGGTTAGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGC AGCACAAGAGATGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACACACACAGAGGAAAGACGCTCTTTAGGTTTTGTTTTGTTTTTTT TTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAACACTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCT TTCCTAATAATATGGTTCAACTGTGAATGTAGAAGTGGGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATA TAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAAAAATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGC ACAAAGAAAACGCCCTCTCCTGACTTGTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGTTTAGAAAAATAAATATACA ATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTAACTATTTTGGATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGA TAAAATAACCATTTGGAAACTGCTTGGCCTTCTGTTCTTTTATTTGATTGACTACAATGCGGTATTGGTCTCTTGCTGCACTTCAAAAGC AACCAACAAAACAAAAACAAAAAAAAGTGTGTGTTGTGTGAATACACACACACACTAACTAGAAGTCTTGTGATGAAAATGGCACTTGGA AAAGGTTTTATTTTTCCACTGAAGTTGAAGGTTAATAAAATGGTGTCAAACGTCCCCTGGTCACACACTTGAATATTTTTTTAGAAGTGT GATGTGGTATGATTACCATAAATCAGACTTAATTATTTTCCCTTTTACAAGGGAACAGGGCATCCTGAATTTTAGAGCCTTTCAGCAATA AGAAGGGATGTTGGTGAGCTTTGATCCTCTTTTGGTTTTGCAGTTGTTAGGAGTTTTTGCTGGCATTTTGAATATGCTGCTTTCAGAAAA ACCAAGGAAGTTTTAAAATTGCTTCCTGGTCCTTAGAGGACTAAAAACAAGACCCTCATTCCCACTTTCATTTCCACTCTAGCAAAAACT GGGCTTGCGTTTTTCTCCAACTCCTCGTTTATATCCTCCCTTCCATGTCCAAGCCTTCCATTCCTAAGTGGGATTGGCTCAGTTTTGCCC ATCCATATGGCAGCATCTCTAATAGCTCTTGTACAGGGTATCAGATATTGTGCCTTTTGGTGCCAGGTTCAAAGTCAAGTGCCGATCTAT GAACCAGTGTACAAAAAAAAAAAAATCCAGGTATTTGAAGGAGAGACGCTCCATTGTGAATAAAGAGCTCATACCAGCTCCTAAGCCCTA TTAAGAAGAGGCCTGGTCCTCTAATGCCTTGTTTCCATTTCAGTTGTTCTTTGAGAGACAGAATGATGTACTAACCATTCGTGATTATTA AGATAGGGTTGGGTCAGGGCTTAGGGAGGGGGCAGAAATATTGGGGATAGAAAAAAAATCTGATCATTCCTCAGTGCTACCCATTTCTGT CCTGTGTGGGCTGCTTAGCTAGACAGCAGGAGAATAAAGTACACCGAGAACCATAATGAAAAAACCTTCCGTGTGTTTTGTCATGTTTTG TTCCAGGGAAGCAGTTGATGAGTGCTGTTACTAATGCTTTCTCCCAGATCCATTCAGTGGTGGAGAGGAGGAAAATGGGCTGGTTGGATG TGGTCTTGGTGCCTTGCAGTTACTCTGCACTGGTTATGCATTTAATTCTCCTCTTTTCTAGTTAACCTTTTGCCAGTGGGTTTTCCATAG TCTGGGTATTTGTCCTTATATCAGTTATACCACCTAAGGCAACTGGGTGCAAAATGCATTCTGTTCACTCACTGTCTGGGCCTTCCCCAC CCTAGTCTTGGCACATTCCTTCAAGAATGTAGTTACCGTCTGCTTGGGAAGATGTCAGTGCAAATGTGAAGATAATGGGCATCGGACTAG GCTTTGGTTTGCCACAAGTGGCAGCTGCCTGTATCAATTACATTTATTAATTTTGCTTTTCATTTTTCCCAGTTCTCCTCACCCCCCCTT TGTTGAAATGTTGGACTTGCTGTCAGAGGCAACTGTAATATTGCCTTAGGGACTTGTGGAGAAGGGGAATTGCTCAGTGTAGTGTTTTAA CTTTCAGAACCAAGCAATCTATTTACTCTTACAAATATTTAAGAAGTGTGTTAGTCCAACTTTAAGAAAAATCCAAACTCATCAGCTTTT GATAGCATCTTGGTTTTTGAAACAACTTCAATCTGTAATTGGCATTCAGAATGCCCTTGGCATGCCAGTCTGTGATGGCATTTAAGACCT >In-frame_ENST00000530173_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=725AA_start in transcript=30_stop in transcript=2207 MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNL VKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLT KQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPS VVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLL ETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDAL QISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDE VMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQE NVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRK -------------------------------------------------------------- >In-frame_ENST00000530173_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2484nt_BP=273nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTT GCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATG GATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTAT CTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGC CTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGG TACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCC ACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAA GCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGC TGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCT TCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCT CTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTT CTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTT CTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCT GGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAA CCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTG CAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCG CAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAG GCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGA ATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATT GACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAG GATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTT GCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAA ATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAA ACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGA >In-frame_ENST00000530173_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=725AA_start in transcript=30_stop in transcript=2207 MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNL VKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLT KQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPS VVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLL ETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDAL QISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDE VMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQE NVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRK -------------------------------------------------------------- >In-frame_ENST00000530173_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2271nt_BP=273nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTT GCAGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGAC ATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGT ATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTA GTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTG CTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTAT GAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAG ACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGAT TGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCC GATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAG ATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTT AGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCT GAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTG ATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTT GCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTAT GACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAAC GTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGAT GGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATG ATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTG AAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGG AGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCA GCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAA >In-frame_ENST00000530173_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=654AA_start in transcript=30_stop in transcript=1994 MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNL VKIMSLYYQYMETYMGPALFADENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQL KPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQE EPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQS LLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVG LVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELR ESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRR -------------------------------------------------------------- >In-frame_ENST00000322157_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2656nt_BP=492nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATAT TATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAA GGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAG CACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGAT GACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTC CCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAG CCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCT GCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAG GGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCT GATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGAT GGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAG AAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAAT GACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATG GCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTG TTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTG GCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAA AATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTT AAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTG AATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATG CTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCT GCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACT GAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCT GTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGA ATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGC >In-frame_ENST00000322157_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=786AA_start in transcript=66_stop in transcript=2426 MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKS DIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALM AVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDH -------------------------------------------------------------- >In-frame_ENST00000322157_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=5528nt_BP=492nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATAT TATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAA GGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAG CACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGAT GACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTC CCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAG CCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCT GCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAG GGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCT GATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGAT GGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAG AAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAAT GACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATG GCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTG TTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTG GCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAA AATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTT AAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTG AATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATG CTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCT GCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACT GAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCT GTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGA ATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGC AGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAGTTACTTA TTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGTCTTTTGGCCAGTGCCGAGTGGAATGCCTGG TTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCT GGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGGTACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGA GAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTTTCAACTTCAAGTCATTGCAGTTTCTTTTTCCCAGAAAACAAGGGGTTAGATGTT GCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGATGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACACACA CAGAGGAAAGACGCTCTTTAGGTTTTGTTTTGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAACACTGACGAAT GGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATGGTTCAACTGTGAATGTAGAAGTGGGGGGGAGGGGGGA GAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATATAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAAAAATCACAA CCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGACTTGTATTGTGGCAGTCTGAACGCCCCC AGAAAATTGTGCCAAAGAGTTTAGAAAAATAAATATACAATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTAACTATTTTG GATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGCTTGGCCTTCTGTTCTTTTATTTGATTGA CTACAATGCGGTATTGGTCTCTTGCTGCACTTCAAAAGCAACCAACAAAACAAAAACAAAAAAAAGTGTGTGTTGTGTGAATACACACAC ACACTAACTAGAAGTCTTGTGATGAAAATGGCACTTGGAAAAGGTTTTATTTTTCCACTGAAGTTGAAGGTTAATAAAATGGTGTCAAAC GTCCCCTGGTCACACACTTGAATATTTTTTTAGAAGTGTGATGTGGTATGATTACCATAAATCAGACTTAATTATTTTCCCTTTTACAAG GGAACAGGGCATCCTGAATTTTAGAGCCTTTCAGCAATAAGAAGGGATGTTGGTGAGCTTTGATCCTCTTTTGGTTTTGCAGTTGTTAGG AGTTTTTGCTGGCATTTTGAATATGCTGCTTTCAGAAAAACCAAGGAAGTTTTAAAATTGCTTCCTGGTCCTTAGAGGACTAAAAACAAG ACCCTCATTCCCACTTTCATTTCCACTCTAGCAAAAACTGGGCTTGCGTTTTTCTCCAACTCCTCGTTTATATCCTCCCTTCCATGTCCA AGCCTTCCATTCCTAAGTGGGATTGGCTCAGTTTTGCCCATCCATATGGCAGCATCTCTAATAGCTCTTGTACAGGGTATCAGATATTGT GCCTTTTGGTGCCAGGTTCAAAGTCAAGTGCCGATCTATGAACCAGTGTACAAAAAAAAAAAAATCCAGGTATTTGAAGGAGAGACGCTC CATTGTGAATAAAGAGCTCATACCAGCTCCTAAGCCCTATTAAGAAGAGGCCTGGTCCTCTAATGCCTTGTTTCCATTTCAGTTGTTCTT TGAGAGACAGAATGATGTACTAACCATTCGTGATTATTAAGATAGGGTTGGGTCAGGGCTTAGGGAGGGGGCAGAAATATTGGGGATAGA AAAAAAATCTGATCATTCCTCAGTGCTACCCATTTCTGTCCTGTGTGGGCTGCTTAGCTAGACAGCAGGAGAATAAAGTACACCGAGAAC CATAATGAAAAAACCTTCCGTGTGTTTTGTCATGTTTTGTTCCAGGGAAGCAGTTGATGAGTGCTGTTACTAATGCTTTCTCCCAGATCC ATTCAGTGGTGGAGAGGAGGAAAATGGGCTGGTTGGATGTGGTCTTGGTGCCTTGCAGTTACTCTGCACTGGTTATGCATTTAATTCTCC TCTTTTCTAGTTAACCTTTTGCCAGTGGGTTTTCCATAGTCTGGGTATTTGTCCTTATATCAGTTATACCACCTAAGGCAACTGGGTGCA AAATGCATTCTGTTCACTCACTGTCTGGGCCTTCCCCACCCTAGTCTTGGCACATTCCTTCAAGAATGTAGTTACCGTCTGCTTGGGAAG ATGTCAGTGCAAATGTGAAGATAATGGGCATCGGACTAGGCTTTGGTTTGCCACAAGTGGCAGCTGCCTGTATCAATTACATTTATTAAT TTTGCTTTTCATTTTTCCCAGTTCTCCTCACCCCCCCTTTGTTGAAATGTTGGACTTGCTGTCAGAGGCAACTGTAATATTGCCTTAGGG ACTTGTGGAGAAGGGGAATTGCTCAGTGTAGTGTTTTAACTTTCAGAACCAAGCAATCTATTTACTCTTACAAATATTTAAGAAGTGTGT TAGTCCAACTTTAAGAAAAATCCAAACTCATCAGCTTTTGATAGCATCTTGGTTTTTGAAACAACTTCAATCTGTAATTGGCATTCAGAA TGCCCTTGGCATGCCAGTCTGTGATGGCATTTAAGACCTGTAAAACACTTGAGCCCAACTCGATTAACCAAAACCGATAACCACCACCTT >In-frame_ENST00000322157_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=786AA_start in transcript=66_stop in transcript=2426 MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKS DIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALM AVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDH -------------------------------------------------------------- >In-frame_ENST00000322157_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2703nt_BP=492nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATAT TATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAA GGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAG CACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGAT GACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTC CCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAG CCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCT GCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAG GGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCT GATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGAT GGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAG AAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAAT GACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATG GCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTG TTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTG GCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAA AATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTT AAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTG AATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATG CTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCT GCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACT GAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCT GTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGA ATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGC AGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAGTTACTTA >In-frame_ENST00000322157_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=786AA_start in transcript=66_stop in transcript=2426 MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKS DIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALM AVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDH -------------------------------------------------------------- >In-frame_ENST00000322157_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2490nt_BP=492nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATAT TATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGG GTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGAT TGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCT ATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTT CCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAAT GTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTA TCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATAT GAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAA CAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAG AATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCT GGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCC TTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGT GCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTG AAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTT CAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTAT ACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCT TTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTT GGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAA ACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCA CTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGC TTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTT >In-frame_ENST00000322157_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=715AA_start in transcript=66_stop in transcript=2213 MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQYMETYMGPALFADENDDDDD WNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWT VGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQ NNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASL LRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLG NENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQ -------------------------------------------------------------- >In-frame_ENST00000544660_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2393nt_BP=229nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTC CTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGC TTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCC CCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAA TGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACA TGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGG ACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGA TACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCT GATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGA CGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAG ACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGC TGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCA GTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGT GGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGT GGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGT TTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCT TCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGG AGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGA TTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGA TGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGC TTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATT GTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGC TTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGG ATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGC >In-frame_ENST00000544660_ENST00000535458_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=716AA_start in transcript=13_stop in transcript=2163 MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQ YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAW TVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMAS LLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENL GNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLV -------------------------------------------------------------- >In-frame_ENST00000544660_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=5265nt_BP=229nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTC CTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGC TTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCC CCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAA TGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACA TGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGG ACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGA TACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCT GATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGA CGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAG ACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGC TGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCA GTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGT GGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGT GGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGT TTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCT TCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGG AGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGA TTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGA TGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGC TTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATT GTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGC TTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGG ATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGC CAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAG TTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGTCTTTTGGCCAGTGCCGAGTGGAA TGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGAT GGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGGTACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTAC AGTCTGAGAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTTTCAACTTCAAGTCATTGCAGTTTCTTTTTCCCAGAAAACAAGGGGTT AGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGATGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAC ACACACACAGAGGAAAGACGCTCTTTAGGTTTTGTTTTGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAACACT GACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATGGTTCAACTGTGAATGTAGAAGTGGGGGGGA GGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATATAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAAAA ATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGACTTGTATTGTGGCAGTCTGAA CGCCCCCAGAAAATTGTGCCAAAGAGTTTAGAAAAATAAATATACAATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTAAC TATTTTGGATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGCTTGGCCTTCTGTTCTTTTATT TGATTGACTACAATGCGGTATTGGTCTCTTGCTGCACTTCAAAAGCAACCAACAAAACAAAAACAAAAAAAAGTGTGTGTTGTGTGAATA CACACACACACTAACTAGAAGTCTTGTGATGAAAATGGCACTTGGAAAAGGTTTTATTTTTCCACTGAAGTTGAAGGTTAATAAAATGGT GTCAAACGTCCCCTGGTCACACACTTGAATATTTTTTTAGAAGTGTGATGTGGTATGATTACCATAAATCAGACTTAATTATTTTCCCTT TTACAAGGGAACAGGGCATCCTGAATTTTAGAGCCTTTCAGCAATAAGAAGGGATGTTGGTGAGCTTTGATCCTCTTTTGGTTTTGCAGT TGTTAGGAGTTTTTGCTGGCATTTTGAATATGCTGCTTTCAGAAAAACCAAGGAAGTTTTAAAATTGCTTCCTGGTCCTTAGAGGACTAA AAACAAGACCCTCATTCCCACTTTCATTTCCACTCTAGCAAAAACTGGGCTTGCGTTTTTCTCCAACTCCTCGTTTATATCCTCCCTTCC ATGTCCAAGCCTTCCATTCCTAAGTGGGATTGGCTCAGTTTTGCCCATCCATATGGCAGCATCTCTAATAGCTCTTGTACAGGGTATCAG ATATTGTGCCTTTTGGTGCCAGGTTCAAAGTCAAGTGCCGATCTATGAACCAGTGTACAAAAAAAAAAAAATCCAGGTATTTGAAGGAGA GACGCTCCATTGTGAATAAAGAGCTCATACCAGCTCCTAAGCCCTATTAAGAAGAGGCCTGGTCCTCTAATGCCTTGTTTCCATTTCAGT TGTTCTTTGAGAGACAGAATGATGTACTAACCATTCGTGATTATTAAGATAGGGTTGGGTCAGGGCTTAGGGAGGGGGCAGAAATATTGG GGATAGAAAAAAAATCTGATCATTCCTCAGTGCTACCCATTTCTGTCCTGTGTGGGCTGCTTAGCTAGACAGCAGGAGAATAAAGTACAC CGAGAACCATAATGAAAAAACCTTCCGTGTGTTTTGTCATGTTTTGTTCCAGGGAAGCAGTTGATGAGTGCTGTTACTAATGCTTTCTCC CAGATCCATTCAGTGGTGGAGAGGAGGAAAATGGGCTGGTTGGATGTGGTCTTGGTGCCTTGCAGTTACTCTGCACTGGTTATGCATTTA ATTCTCCTCTTTTCTAGTTAACCTTTTGCCAGTGGGTTTTCCATAGTCTGGGTATTTGTCCTTATATCAGTTATACCACCTAAGGCAACT GGGTGCAAAATGCATTCTGTTCACTCACTGTCTGGGCCTTCCCCACCCTAGTCTTGGCACATTCCTTCAAGAATGTAGTTACCGTCTGCT TGGGAAGATGTCAGTGCAAATGTGAAGATAATGGGCATCGGACTAGGCTTTGGTTTGCCACAAGTGGCAGCTGCCTGTATCAATTACATT TATTAATTTTGCTTTTCATTTTTCCCAGTTCTCCTCACCCCCCCTTTGTTGAAATGTTGGACTTGCTGTCAGAGGCAACTGTAATATTGC CTTAGGGACTTGTGGAGAAGGGGAATTGCTCAGTGTAGTGTTTTAACTTTCAGAACCAAGCAATCTATTTACTCTTACAAATATTTAAGA AGTGTGTTAGTCCAACTTTAAGAAAAATCCAAACTCATCAGCTTTTGATAGCATCTTGGTTTTTGAAACAACTTCAATCTGTAATTGGCA TTCAGAATGCCCTTGGCATGCCAGTCTGTGATGGCATTTAAGACCTGTAAAACACTTGAGCCCAACTCGATTAACCAAAACCGATAACCA >In-frame_ENST00000544660_ENST00000290158_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=716AA_start in transcript=13_stop in transcript=2163 MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQ YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAW TVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMAS LLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENL GNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLV -------------------------------------------------------------- >In-frame_ENST00000544660_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2440nt_BP=229nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTC CTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGC TTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCC CCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAA TGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACA TGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGG ACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGA TACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCT GATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGA CGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAG ACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGC TGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCA GTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGT GGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGT GGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGT TTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCT TCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGG AGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGA TTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGA TGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGC TTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATT GTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGC TTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGG ATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGC CAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAG >In-frame_ENST00000544660_ENST00000540627_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=716AA_start in transcript=13_stop in transcript=2163 MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQ YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDD DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAW TVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMAS LLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENL GNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLV -------------------------------------------------------------- >In-frame_ENST00000544660_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(transcript)=2227nt_BP=229nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTC CTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGC AGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAA CCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTAT ACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGA GCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGC TTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTA CTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTC TGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACG ACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAAC TCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAG CACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACAT GGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTT GTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAG GTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAA TACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGA AGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTAT TCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTAC AGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAA AGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGG ACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGA GTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCA >In-frame_ENST00000544660_ENST00000537679_TCGA-78-8648-01A_NPEPPS_chr17_45608921_+_KPNB1_chr17_45740455_length(amino acids)=645AA_start in transcript=13_stop in transcript=1950 MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRVAALQNLVKIMSLYYQ YMETYMGPALFADENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMP TLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSS SFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNV LRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRAL QSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTG IVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NPEPPS-KPNB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NPEPPS-KPNB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NPEPPS-KPNB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KPNB1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | KPNB1 | C4505456 | HIV Coinfection | 1 | CTD_human |
| Tgene | KPNB1 | C4721610 | Carcinoma, Ovarian Epithelial | 1 | CTD_human |
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