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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NPLOC4-HEXDC (FusionGDB2 ID:59587)

Fusion Gene Summary for NPLOC4-HEXDC

check button Fusion gene summary
Fusion gene informationFusion gene name: NPLOC4-HEXDC
Fusion gene ID: 59587
HgeneTgene
Gene symbol

NPLOC4

HEXDC

Gene ID

55666

284004

Gene nameNPL4 homolog, ubiquitin recognition factorhexosaminidase D
SynonymsNPL4HEXDC
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homologhexosaminidase DN-acetyl-beta-galactosaminidasebeta-N-acetylhexosaminidasebeta-hexosaminidase Dhexosaminidase (glycosyl hydrolase family 20, catalytic domain) containinghexosaminidase D, cytosolichexosaminidase domain-containing protein
Modification date2020031320200313
UniProtAcc

Q8TAT6

.
Ensembl transtripts involved in fusion geneENST00000331134, ENST00000374747, 
ENST00000539314, ENST00000572760, 
ENST00000573876, ENST00000574344, 
ENST00000337014, ENST00000577944, 
ENST00000327949, 
Fusion gene scores* DoF score19 X 17 X 11=35537 X 7 X 5=245
# samples 309
** MAII scorelog2(30/3553*10)=-3.56600328283534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPLOC4 [Title/Abstract] AND HEXDC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHEXDC(80386521)-NPLOC4(79539114), # samples:2
NPLOC4(79589192)-HEXDC(80386434), # samples:1
NPLOC4(79589191)-HEXDC(80386433), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NPLOC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HEXDC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1861-01ANPLOC4chr17

79589192

-HEXDCchr17

80386434

+
ChimerDB4OVTCGA-30-1861NPLOC4chr17

79589191

-HEXDCchr17

80386433

+


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Fusion Gene ORF analysis for NPLOC4-HEXDC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000331134ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000331134ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000331134ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000374747ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000374747ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000374747ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
5UTR-3CDSENST00000539314ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
5UTR-3CDSENST00000539314ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
5UTR-3CDSENST00000539314ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000572760ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000572760ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000572760ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000573876ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000573876ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000573876ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000574344ENST00000337014NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000574344ENST00000577944NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
intron-3CDSENST00000574344ENST00000327949NPLOC4chr17

79589192

-HEXDCchr17

80386434

+
In-frameENST00000331134ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
In-frameENST00000331134ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
In-frameENST00000331134ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
In-frameENST00000374747ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
In-frameENST00000374747ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
In-frameENST00000374747ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
5UTR-3CDSENST00000539314ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
5UTR-3CDSENST00000539314ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
5UTR-3CDSENST00000539314ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000572760ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000572760ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000572760ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000573876ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000573876ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000573876ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000574344ENST00000337014NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000574344ENST00000577944NPLOC4chr17

79589191

-HEXDCchr17

80386433

+
intron-3CDSENST00000574344ENST00000327949NPLOC4chr17

79589191

-HEXDCchr17

80386433

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331134NPLOC4chr1779589192-ENST00000337014HEXDCchr1780386434+204242531988661
ENST00000331134NPLOC4chr1779589192-ENST00000577944HEXDCchr1780386434+195642531865620
ENST00000331134NPLOC4chr1779589192-ENST00000327949HEXDCchr1780386434+195342531691562
ENST00000374747NPLOC4chr1779589192-ENST00000337014HEXDCchr1780386434+195633911902633
ENST00000374747NPLOC4chr1779589192-ENST00000577944HEXDCchr1780386434+187033911779592
ENST00000374747NPLOC4chr1779589192-ENST00000327949HEXDCchr1780386434+186733911605534
ENST00000331134NPLOC4chr1779589191-ENST00000337014HEXDCchr1780386433+204242531988661
ENST00000331134NPLOC4chr1779589191-ENST00000577944HEXDCchr1780386433+195642531865620
ENST00000331134NPLOC4chr1779589191-ENST00000327949HEXDCchr1780386433+195342531691562
ENST00000374747NPLOC4chr1779589191-ENST00000337014HEXDCchr1780386433+195633911902633
ENST00000374747NPLOC4chr1779589191-ENST00000577944HEXDCchr1780386433+187033911779592
ENST00000374747NPLOC4chr1779589191-ENST00000327949HEXDCchr1780386433+186733911605534

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331134ENST00000337014NPLOC4chr1779589192-HEXDCchr1780386434+0.151186060.8488139
ENST00000331134ENST00000577944NPLOC4chr1779589192-HEXDCchr1780386434+0.153004880.8469951
ENST00000331134ENST00000327949NPLOC4chr1779589192-HEXDCchr1780386434+0.02112250.9788775
ENST00000374747ENST00000337014NPLOC4chr1779589192-HEXDCchr1780386434+0.154647290.8453527
ENST00000374747ENST00000577944NPLOC4chr1779589192-HEXDCchr1780386434+0.155110480.8448895
ENST00000374747ENST00000327949NPLOC4chr1779589192-HEXDCchr1780386434+0.0210563670.97894365
ENST00000331134ENST00000337014NPLOC4chr1779589191-HEXDCchr1780386433+0.151186060.8488139
ENST00000331134ENST00000577944NPLOC4chr1779589191-HEXDCchr1780386433+0.153004880.8469951
ENST00000331134ENST00000327949NPLOC4chr1779589191-HEXDCchr1780386433+0.02112250.9788775
ENST00000374747ENST00000337014NPLOC4chr1779589191-HEXDCchr1780386433+0.154647290.8453527
ENST00000374747ENST00000577944NPLOC4chr1779589191-HEXDCchr1780386433+0.155110480.8448895
ENST00000374747ENST00000327949NPLOC4chr1779589191-HEXDCchr1780386433+0.0210563670.97894365

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Fusion Genomic Features for NPLOC4-HEXDC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NPLOC4chr1779589191-HEXDCchr1780386433+4.30E-131
NPLOC4chr1779589191-HEXDCchr1780386433+4.30E-131
NPLOC4chr1779589191-HEXDCchr1780386433+4.30E-131
NPLOC4chr1779589191-HEXDCchr1780386433+4.30E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NPLOC4-HEXDC


check button Go to

FGviewer for the breakpoints of chr17:79589192-chr17:80386434

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPLOC4

Q8TAT6

.
FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPLOC4chr17:79589191chr17:80386433ENST00000331134-317226_36369.66666666666667609.0DomainMPN
HgeneNPLOC4chr17:79589191chr17:80386433ENST00000374747-316226_36369.66666666666667618.0DomainMPN
HgeneNPLOC4chr17:79589192chr17:80386434ENST00000331134-317226_36369.66666666666667609.0DomainMPN
HgeneNPLOC4chr17:79589192chr17:80386434ENST00000374747-316226_36369.66666666666667618.0DomainMPN
HgeneNPLOC4chr17:79589191chr17:80386433ENST00000331134-317580_60869.66666666666667609.0Zinc fingerRanBP2-type
HgeneNPLOC4chr17:79589191chr17:80386433ENST00000374747-316580_60869.66666666666667618.0Zinc fingerRanBP2-type
HgeneNPLOC4chr17:79589192chr17:80386434ENST00000331134-317580_60869.66666666666667609.0Zinc fingerRanBP2-type
HgeneNPLOC4chr17:79589192chr17:80386434ENST00000374747-316580_60869.66666666666667618.0Zinc fingerRanBP2-type


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Fusion Gene Sequence for NPLOC4-HEXDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000331134_ENST00000337014_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=2042nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGCAAGCACCCTGCAGCCCTCCCTGTCCCCTTCTTCCCCTCCCCTTCCCCCGCCCGTGG
AGACAGCTGTTCTCAGCAGGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTCAGCC
TCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAGCTCA
TCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCTGCCC
TGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTGCAGG
ACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGCCAGG
GGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCCAGCA
GTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAGACCC

>In-frame_ENST00000331134_ENST00000337014_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=661AA_start in transcript=3_stop in transcript=1988
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFPRPWR
QLFSAGLSAGRGPAPSLAATSLPLSHKSASICAALWMRCWRATGMSLAGSAPTTASGSSSTRSWFSTSSPQRSASWHSGAPSCRSWRLPC
SWLSTRMPWRSGWRKTCTPACSGCKLCCRTSARCLPPRCHPPALAGTLLRTPEGRAHARGLLLEAGGALHCQMAWAIRAHVGVVPSGPAV

--------------------------------------------------------------
>In-frame_ENST00000331134_ENST00000577944_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=1956nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACA
AGTCAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCG
GAAGCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGA
GGCTGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCT
GCTGCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTC
ATGCCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTG
GCCCAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAG

>In-frame_ENST00000331134_ENST00000577944_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=620AA_start in transcript=3_stop in transcript=1865
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPGSPQGGGRLLPWQQHPCPCHTS
QPPSAQLCGCAAGGQQVCHWLVQPLPPPAEAHPPGHGSAHPARSAQPPGTVEHPRAGAGGCPAAGFLPGCRGGVAGGKRAPQPAAAASSA

--------------------------------------------------------------
>In-frame_ENST00000331134_ENST00000327949_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=1953nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTCAGC
CTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAGCTC
ATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCTGCC
CTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTGCAG
GACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGCCAG
GGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCCAGC
AGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAGACC

>In-frame_ENST00000331134_ENST00000327949_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=562AA_start in transcript=3_stop in transcript=1691
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVREGAGSFPGSNILALVTQVSL
HLRSSVDALLEGNRYVTGWFSPYHRQRKLIHPVMVQHIQPAALSLLAQWSTLVQELEAALQLAFYPDAVEEWLEENVHPSLQRLQALLQD

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000337014_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=1956nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGCAAGCACCCTGCAGCCCTCCCTGTCCCCTTCTTCCCCTCCCCTTCCCCCGCCC
GTGGAGACAGCTGTTCTCAGCAGGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTC
AGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAG
CTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCT
GCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTG
CAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGC
CAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCC
AGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAG

>In-frame_ENST00000374747_ENST00000337014_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=633AA_start in transcript=1_stop in transcript=1902
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFPRPWRQLFSAGLSAGRGPAPSLAATSLPLSHKS
ASICAALWMRCWRATGMSLAGSAPTTASGSSSTRSWFSTSSPQRSASWHSGAPSCRSWRLPCSWLSTRMPWRSGWRKTCTPACSGCKLCC
RTSARCLPPRCHPPALAGTLLRTPEGRAHARGLLLEAGGALHCQMAWAIRAHVGVVPSGPAVSCPHSVPEGPGQPLGERLENTEGSSTGR

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000577944_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=1870nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCA
CACAAGTCAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCC
AGCGGAAGCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGC
TGGAGGCTGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAG
CTCTGCTGCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGA
GCTCATGCCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCC
TCTGGCCCAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGC

>In-frame_ENST00000374747_ENST00000577944_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=592AA_start in transcript=1_stop in transcript=1779
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPGSPQGGGRLLPWQQHPCPCHTSQPPSAQLCGCAAGGQQVCHWLVQPLPPP
AEAHPPGHGSAHPARSAQPPGTVEHPRAGAGGCPAAGFLPGCRGGVAGGKRAPQPAAAASSAAGPQRGVCPPAATHQPWQGRCSGPLRGE

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000327949_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(transcript)=1867nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGT
CAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAA
GCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGC
TGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCT
GCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATG
CCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCC
CAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGA

>In-frame_ENST00000374747_ENST00000327949_TCGA-30-1861-01A_NPLOC4_chr17_79589192_-_HEXDC_chr17_80386434_length(amino acids)=534AA_start in transcript=1_stop in transcript=1605
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVREGAGSFPGSNILALVTQVSLHLRSSVDALLEGNRYVTGWFSPYHRQRK

--------------------------------------------------------------
>In-frame_ENST00000331134_ENST00000337014_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=2042nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGCAAGCACCCTGCAGCCCTCCCTGTCCCCTTCTTCCCCTCCCCTTCCCCCGCCCGTGG
AGACAGCTGTTCTCAGCAGGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTCAGCC
TCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAGCTCA
TCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCTGCCC
TGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTGCAGG
ACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGCCAGG
GGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCCAGCA
GTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAGACCC

>In-frame_ENST00000331134_ENST00000337014_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=661AA_start in transcript=3_stop in transcript=1988
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFPRPWR
QLFSAGLSAGRGPAPSLAATSLPLSHKSASICAALWMRCWRATGMSLAGSAPTTASGSSSTRSWFSTSSPQRSASWHSGAPSCRSWRLPC
SWLSTRMPWRSGWRKTCTPACSGCKLCCRTSARCLPPRCHPPALAGTLLRTPEGRAHARGLLLEAGGALHCQMAWAIRAHVGVVPSGPAV

--------------------------------------------------------------
>In-frame_ENST00000331134_ENST00000577944_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=1956nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACA
AGTCAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCG
GAAGCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGA
GGCTGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCT
GCTGCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTC
ATGCCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTG
GCCCAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAG

>In-frame_ENST00000331134_ENST00000577944_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=620AA_start in transcript=3_stop in transcript=1865
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPGSPQGGGRLLPWQQHPCPCHTS
QPPSAQLCGCAAGGQQVCHWLVQPLPPPAEAHPPGHGSAHPARSAQPPGTVEHPRAGAGGCPAAGFLPGCRGGVAGGKRAPQPAAAASSA

--------------------------------------------------------------
>In-frame_ENST00000331134_ENST00000327949_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=1953nt_BP=425nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGATCTTG
CATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTTCGCC
CACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCAGGTC
CTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTGGCTA
CAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGTGACA
CCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCTCTGG
GACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGCCAGT
GCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGCGGGC
AGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCCCGCA
GGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCTCGGG
ATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTCAGC
CTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAGCTC
ATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCTGCC
CTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTGCAG
GACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGCCAG
GGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCCAGC
AGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAGACC

>In-frame_ENST00000331134_ENST00000327949_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=562AA_start in transcript=3_stop in transcript=1691
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAH
LREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTP
LVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGS
GPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVREGAGSFPGSNILALVTQVSL
HLRSSVDALLEGNRYVTGWFSPYHRQRKLIHPVMVQHIQPAALSLLAQWSTLVQELEAALQLAFYPDAVEEWLEENVHPSLQRLQALLQD

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000337014_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=1956nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGCAAGCACCCTGCAGCCCTCCCTGTCCCCTTCTTCCCCTCCCCTTCCCCCGCCC
GTGGAGACAGCTGTTCTCAGCAGGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGTC
AGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAAG
CTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGCT
GCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCTG
CAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATGC
CAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCCC
AGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGAG

>In-frame_ENST00000374747_ENST00000337014_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=633AA_start in transcript=1_stop in transcript=1902
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFPRPWRQLFSAGLSAGRGPAPSLAATSLPLSHKS
ASICAALWMRCWRATGMSLAGSAPTTASGSSSTRSWFSTSSPQRSASWHSGAPSCRSWRLPCSWLSTRMPWRSGWRKTCTPACSGCKLCC
RTSARCLPPRCHPPALAGTLLRTPEGRAHARGLLLEAGGALHCQMAWAIRAHVGVVPSGPAVSCPHSVPEGPGQPLGERLENTEGSSTGR

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000577944_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=1870nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGGCTCTCCGCAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCA
CACAAGTCAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCC
AGCGGAAGCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGC
TGGAGGCTGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAG
CTCTGCTGCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGA
GCTCATGCCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCC
TCTGGCCCAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGC

>In-frame_ENST00000374747_ENST00000577944_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=592AA_start in transcript=1_stop in transcript=1779
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPGSPQGGGRLLPWQQHPCPCHTSQPPSAQLCGCAAGGQQVCHWLVQPLPPP
AEAHPPGHGSAHPARSAQPPGTVEHPRAGAGGCPAAGFLPGCRGGVAGGKRAPQPAAAASSAAGPQRGVCPPAATHQPWQGRCSGPLRGE

--------------------------------------------------------------
>In-frame_ENST00000374747_ENST00000327949_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(transcript)=1867nt_BP=339nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAACCCCTCTGAAATCAAAGAGAT
CTTGCATCTGGCTGGACTCAATGAGCTGGAGGTGATTCCCTTGGTGCAGACATTTGGACACATGGAGTTTGTGCTGAAGCACACGGCCTT
CGCCCACCTGCGGGAGGTGGGCTCCTTCCCCTGCACCCTGAACCCCCACGAGGCAGAGTCCCTGGCGCTGGTGGGCGCCATGATTGACCA
GGTCCTGGAGCTACACCCAGGCGCCCAGCGGCTGCACATCGGGTGTGATGAGGTCTATTACCTCGGAGAGGGGGAGGCCTCGCGCCGGTG
GCTACAGCAAGAGCAGAACAGCACGGGGAAGTTGTGCCTGTCACACATGCGGGCGGTGGCCAGCGGCGTGAAGGCCCGGCGCCCCAGCGT
GACACCCCTGGTGTGGGACGACATGCTCCGAGACCTGCCTGAGGACCAGCTCGCAGCGTCCGGGGTGCCGCAGCTGGTGGAGCCGGTGCT
CTGGGACTACACGGCCGACCTGGATGTGCACGGCAAGGTCCTCCTCATGCAGAAGTACCGGCGGTGCGGCTTTCCGCAGCTGTGGGCAGC
CAGTGCCTTCAAGGGTGCCACGGGGCCCAGCCAGGCCGTGCCCCCTGTTGAGCACCACCTCAGGAACCACGTGCAGTGGCTGCAGGTGGC
GGGCAGCGGGCCCACGGACTCACTGCAGGGCATCATCCTGACCGGCTGGCAGAGGTACGACCACTACTCTGTGCTGTGCGAGCTGCTGCC
CGCAGGAGTCCCGTCCCTGGCCGCCTGCCTGCAGTTGCTTCTACGCGGAGGATTTGATGAAGATGTTAAAGCGAAAGTGGAGAACCTTCT
CGGGATTTCCAGCCTGGAAAAAACGGACCCTGTTAGGGAGGGGGCCGGCTCCTTCCCTGGCAGCAACATCCTTGCCCTTGTCACACAAGT
CAGCCTCCATCTGCGCAGCTCTGTGGATGCGCTGCTGGAGGGCAACAGGTATGTCACTGGCTGGTTCAGCCCCTACCACCGCCAGCGGAA
GCTCATCCACCCGGTCATGGTTCAGCACATCCAGCCCGCAGCGCTCAGCCTCCTGGCACAGTGGAGCACCCTCGTGCAGGAGCTGGAGGC
TGCCCTGCAGCTGGCTTTCTACCCGGATGCCGTGGAGGAGTGGCTGGAGGAAAACGTGCACCCCAGCCTGCAGCGGCTGCAAGCTCTGCT
GCAGGACCTCAGCGAGGTGTCTGCCCCCCCGCTGCCACCCACCAGCCCTGGCAGGGACGTTGCTCAGGACCCCTGAGGGGAGAGCTCATG
CCAGGGGGCTCCTGCTGGAGGCTGGGGGGGCTCTGCACTGCCAAATGGCCTGGGCAATACGGGCCCACGTGGGCGTCGTGCCCTCTGGCC
CAGCAGTGTCTTGCCCACACTCAGTTCCTGAGGGCCCTGGGCAGCCCCTGGGGGAGAGACTAGAAAACACAGAAGGAAGCAGCACAGGGA

>In-frame_ENST00000374747_ENST00000327949_TCGA-30-1861_NPLOC4_chr17_79589191_-_HEXDC_chr17_80386433_length(amino acids)=534AA_start in transcript=1_stop in transcript=1605
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKINPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQ
VLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVL
WDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLP
AGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVREGAGSFPGSNILALVTQVSLHLRSSVDALLEGNRYVTGWFSPYHRQRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NPLOC4-HEXDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NPLOC4-HEXDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NPLOC4-HEXDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource