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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGEF1-SHC1 (FusionGDB2 ID:5968)

Fusion Gene Summary for ARFGEF1-SHC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF1-SHC1
Fusion gene ID: 5968
HgeneTgene
Gene symbol

ARFGEF1

SHC1

Gene ID

10565

6464

Gene nameADP ribosylation factor guanine nucleotide exchange factor 1SHC adaptor protein 1
SynonymsARFGEP1|BIG1|P200SHC|SHCA
Cytomap

8q13.2

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factorSHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A
Modification date2020031320200327
UniProtAcc

Q9Y6D6

.
Ensembl transtripts involved in fusion geneENST00000520381, ENST00000262215, 
ENST00000517955, ENST00000518230, 
ENST00000368445, ENST00000368449, 
ENST00000448116, ENST00000368450, 
ENST00000368453, ENST00000606391, 
ENST00000490667, 
Fusion gene scores* DoF score14 X 14 X 6=117611 X 4 X 8=352
# samples 1710
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/352*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF1 [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF1(68211444)-SHC1(154942675), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF1

GO:0034260

negative regulation of GTPase activity

15644318

TgeneSHC1

GO:0000165

MAPK cascade

14676841

TgeneSHC1

GO:0000187

activation of MAPK activity

14676841

TgeneSHC1

GO:0071363

cellular response to growth factor stimulus

20010870


check buttonFusion gene breakpoints across ARFGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EI-01AARFGEF1chr8

68211444

-SHC1chr1

154942675

-
ChimerDB4SARCTCGA-DX-A7EI-01AARFGEF1chr8

68211444

-SHC1chr1

154942675

-
ChimerDB4SARCTCGA-DX-A7EI-01AARFGEF1chr8

68211444

-SHC1chr1

154942675

-


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Fusion Gene ORF analysis for ARFGEF1-SHC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000520381ENST00000368445ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000520381ENST00000368449ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000520381ENST00000448116ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000520381ENST00000368450ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000520381ENST00000368453ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000520381ENST00000606391ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000520381ENST00000490667ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
In-frameENST00000262215ENST00000368445ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-intronENST00000262215ENST00000368449ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-intronENST00000262215ENST00000448116ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-5UTRENST00000262215ENST00000368450ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-5UTRENST00000262215ENST00000368453ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-intronENST00000262215ENST00000606391ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
5CDS-intronENST00000262215ENST00000490667ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-3CDSENST00000517955ENST00000368445ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000517955ENST00000368449ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000517955ENST00000448116ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000517955ENST00000368450ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000517955ENST00000368453ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000517955ENST00000606391ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000517955ENST00000490667ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-3CDSENST00000518230ENST00000368445ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000518230ENST00000368449ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000518230ENST00000448116ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000518230ENST00000368450ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-5UTRENST00000518230ENST00000368453ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000518230ENST00000606391ARFGEF1chr8

68211444

-SHC1chr1

154942675

-
intron-intronENST00000518230ENST00000490667ARFGEF1chr8

68211444

-SHC1chr1

154942675

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262215ARFGEF1chr868211444-ENST00000368445SHC1chr1154942675-3779849390977195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262215ENST00000368445ARFGEF1chr868211444-SHC1chr1154942675-0.0087796060.9912204

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Fusion Genomic Features for ARFGEF1-SHC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARFGEF1-SHC1


check button Go to

FGviewer for the breakpoints of chr8:68211444-chr1:154942675

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFGEF1

Q9Y6D6

.
FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSHC1chr8:68211444chr1:154942675ENST00000368445012411_4740584.0Compositional biasNote=Pro-rich
TgeneSHC1chr8:68211444chr1:154942675ENST00000368450013411_4740474.0Compositional biasNote=Pro-rich
TgeneSHC1chr8:68211444chr1:154942675ENST00000368453013411_4740475.0Compositional biasNote=Pro-rich
TgeneSHC1chr8:68211444chr1:154942675ENST00000448116012411_4740585.0Compositional biasNote=Pro-rich
TgeneSHC1chr8:68211444chr1:154942675ENST00000368445012156_3390584.0DomainPID
TgeneSHC1chr8:68211444chr1:154942675ENST00000368445012488_5790584.0DomainSH2
TgeneSHC1chr8:68211444chr1:154942675ENST00000368450013156_3390474.0DomainPID
TgeneSHC1chr8:68211444chr1:154942675ENST00000368450013488_5790474.0DomainSH2
TgeneSHC1chr8:68211444chr1:154942675ENST00000368453013156_3390475.0DomainPID
TgeneSHC1chr8:68211444chr1:154942675ENST00000368453013488_5790475.0DomainSH2
TgeneSHC1chr8:68211444chr1:154942675ENST00000448116012156_3390585.0DomainPID
TgeneSHC1chr8:68211444chr1:154942675ENST00000448116012488_5790585.0DomainSH2
TgeneSHC1chr8:68211444chr1:154942675ENST00000368445012340_4870584.0RegionNote=CH1
TgeneSHC1chr8:68211444chr1:154942675ENST00000368450013340_4870474.0RegionNote=CH1
TgeneSHC1chr8:68211444chr1:154942675ENST00000368453013340_4870475.0RegionNote=CH1
TgeneSHC1chr8:68211444chr1:154942675ENST00000448116012340_4870585.0RegionNote=CH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF1chr8:68211444chr1:154942675ENST00000262215-439709_840153.01850.0DomainSEC7
HgeneARFGEF1chr8:68211444chr1:154942675ENST00000262215-439711_715153.01850.0MotifNote=Nuclear localization signal (NLS)


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Fusion Gene Sequence for ARFGEF1-SHC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262215_ENST00000368445_TCGA-DX-A7EI-01A_ARFGEF1_chr8_68211444_-_SHC1_chr1_154942675_length(transcript)=3779nt_BP=849nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTAC
CACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCG
CTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTG
TGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTC
TCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGA
AGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCT
GGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATAT
TTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACC
CTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGC
CCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATT
TCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTT
CTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCAT
TGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGG
CTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTG
ACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGA
GGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTC
AGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAG
CAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACG
GGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTTCTTCTAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCC
CCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCT
CAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCT
ACTGGTGGACCCTGAGGGTGTGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTG
GGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGACCTGTAGGACAGCCTGTTGGGGGAGA
TCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAG
CCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCT
CCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGCCTGCCACATTCTGGAGTGTCCCGAAG
GGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCACCC
CTCATGACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGATCATCGCCAACCACCACATGCAATCTA
TCTCATTTGCATCCGGCGGGGATCCGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAA
TCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCG
GGTGCTAAGGGGGCGACAAGGAGGAGAAAGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACT
CAGGTCACCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCC

>In-frame_ENST00000262215_ENST00000368445_TCGA-DX-A7EI-01A_ARFGEF1_chr8_68211444_-_SHC1_chr1_154942675_length(amino acids)=195AA_start in transcript=390_stop in transcript=977
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKVRTKDHRFESVSHLISYHMDNHLPIIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF1-SHC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF1-SHC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF1-SHC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSHC1C0018800Cardiomegaly1CTD_human
TgeneSHC1C0019193Hepatitis, Toxic1CTD_human
TgeneSHC1C0860207Drug-Induced Liver Disease1CTD_human
TgeneSHC1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneSHC1C1383860Cardiac Hypertrophy1CTD_human
TgeneSHC1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneSHC1C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneSHC1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneSHC1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneSHC1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneSHC1C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human