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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NQO2-DDX17 (FusionGDB2 ID:59703)

Fusion Gene Summary for NQO2-DDX17

check button Fusion gene summary
Fusion gene informationFusion gene name: NQO2-DDX17
Fusion gene ID: 59703
HgeneTgene
Gene symbol

NQO2

DDX17

Gene ID

4835

10521

Gene nameN-ribosyldihydronicotinamide:quinone reductase 2DEAD-box helicase 17
SynonymsDHQV|DIA6|NMOR2|QR2P72|RH70
Cytomap

6p25.2

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionribosyldihydronicotinamide dehydrogenase [quinone]NAD(P)H dehydrogenase, quinone 2NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2NAD(P)H quinone dehydrogenase 2NRH:quinone oxidoreductase 2quinone reductase 2ribosyldihydronicotinamide dehydrogprobable ATP-dependent RNA helicase DDX17DEAD (Asp-Glu-Ala-Asp) box helicase 17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17DEAD box protein p72DEAD box protein p82DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)RNA-dependent helicase p72
Modification date2020031320200327
UniProtAcc

P16083

Q92841

Ensembl transtripts involved in fusion geneENST00000338130, ENST00000380441, 
ENST00000380455, ENST00000380454, 
ENST00000380430, ENST00000606474, 
ENST00000396821, ENST00000444597, 
ENST00000381633, ENST00000432525, 
Fusion gene scores* DoF score5 X 4 X 3=6020 X 21 X 7=2940
# samples 525
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2940*10)=-3.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NQO2 [Title/Abstract] AND DDX17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNQO2(3017219)-DDX17(38894578), # samples:1
Anticipated loss of major functional domain due to fusion event.NQO2-DDX17 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNQO2

GO:0055114

oxidation-reduction process

18254726

TgeneDDX17

GO:0045944

positive regulation of transcription by RNA polymerase II

17226766


check buttonFusion gene breakpoints across NQO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DDX17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315378NQO2chr6

3017219

+DDX17chr22

38894578

-


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Fusion Gene ORF analysis for NQO2-DDX17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000338130ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000338130ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000338130ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-5UTRENST00000338130ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-
Frame-shiftENST00000380441ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380441ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380441ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-5UTRENST00000380441ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-
Frame-shiftENST00000380455ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380455ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380455ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-5UTRENST00000380455ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-
Frame-shiftENST00000380454ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380454ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380454ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-5UTRENST00000380454ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-
Frame-shiftENST00000380430ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380430ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-intronENST00000380430ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
5CDS-5UTRENST00000380430ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-
intron-3CDSENST00000606474ENST00000396821NQO2chr6

3017219

+DDX17chr22

38894578

-
intron-intronENST00000606474ENST00000444597NQO2chr6

3017219

+DDX17chr22

38894578

-
intron-intronENST00000606474ENST00000381633NQO2chr6

3017219

+DDX17chr22

38894578

-
intron-5UTRENST00000606474ENST00000432525NQO2chr6

3017219

+DDX17chr22

38894578

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NQO2-DDX17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NQO2-DDX17


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NQO2

P16083

DDX17

Q92841

FUNCTION: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}.FUNCTION: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NQO2-DDX17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NQO2-DDX17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NQO2-DDX17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNQO2P16083DB01087PrimaquineInhibitorSmall moleculeApproved
HgeneNQO2P16083DB01087PrimaquineInhibitorSmall moleculeApproved
HgeneNQO2P16083DB03147Flavin adenine dinucleotideSmall moleculeApproved
HgeneNQO2P16083DB03147Flavin adenine dinucleotideSmall moleculeApproved
HgeneNQO2P16083DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneNQO2P16083DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneNQO2P16083DB00170MenadioneSmall moleculeApproved|Nutraceutical
HgeneNQO2P16083DB00170MenadioneSmall moleculeApproved|Nutraceutical
HgeneNQO2P16083DB01065MelatoninSmall moleculeApproved|Nutraceutical|Vet_approved
HgeneNQO2P16083DB01065MelatoninSmall moleculeApproved|Nutraceutical|Vet_approved

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Related Diseases for NQO2-DDX17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNQO2C0036341Schizophrenia2PSYGENET
HgeneNQO2C0001824Agranulocytosis1CTD_human
HgeneNQO2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNQO2C0005956Bone Marrow Diseases1CTD_human
HgeneNQO2C0011616Contact Dermatitis1CTD_human
HgeneNQO2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNQO2C0025261Memory Disorders1CTD_human
HgeneNQO2C0033975Psychotic Disorders1PSYGENET
HgeneNQO2C0162351Contact hypersensitivity1CTD_human
HgeneNQO2C0233794Memory impairment1CTD_human
HgeneNQO2C0349204Nonorganic psychosis1PSYGENET
HgeneNQO2C0751292Age-Related Memory Disorders1CTD_human
HgeneNQO2C0751293Memory Disorder, Semantic1CTD_human
HgeneNQO2C0751294Memory Disorder, Spatial1CTD_human
HgeneNQO2C0751295Memory Loss1CTD_human