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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NR3C2-SPATA17 (FusionGDB2 ID:59802)

Fusion Gene Summary for NR3C2-SPATA17

check button Fusion gene summary
Fusion gene informationFusion gene name: NR3C2-SPATA17
Fusion gene ID: 59802
HgeneTgene
Gene symbol

NR3C2

SPATA17

Gene ID

4306

128153

Gene namenuclear receptor subfamily 3 group C member 2spermatogenesis associated 17
SynonymsMCR|MLR|MR|NR3C2VITCFAP305|FAP305|IQCH|MOT17|MSRG-11|MSRG11
Cytomap

4q31.23

1q41

Type of geneprotein-codingprotein-coding
Descriptionmineralocorticoid receptoraldosterone receptormineralocorticoid receptor 1mineralocorticoid receptor 2mineralocorticoid receptor deltanuclear receptor subfamily 3, group C, member 2 variant 3spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11
Modification date2020031320200313
UniProtAcc

P08235

.
Ensembl transtripts involved in fusion geneENST00000344721, ENST00000355292, 
ENST00000358102, ENST00000512865, 
ENST00000511528, ENST00000503313, 
ENST00000366933, ENST00000471021, 
Fusion gene scores* DoF score6 X 7 X 3=1267 X 9 X 6=378
# samples 77
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/378*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NR3C2 [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNR3C2(149356256)-SPATA17(218036116), # samples:3
Anticipated loss of major functional domain due to fusion event.NR3C2-SPATA17 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NR3C2-SPATA17 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NR3C2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPATA17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA2T-01ANR3C2chr4

149356256

-SPATA17chr1

218036116

+
ChimerDB4CHOLTCGA-W5-AA2T-01ANR3C2chr4

149356256

-SPATA17chr1

218036116

+
ChimerDB4CHOLTCGA-W5-AA2T-01ANR3C2chr4

149356256

-SPATA17chr1

218036116

+


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Fusion Gene ORF analysis for NR3C2-SPATA17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344721ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000344721ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000355292ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000355292ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000358102ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000358102ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000512865ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000512865ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000511528ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000511528ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
intron-3CDSENST00000503313ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
intron-3UTRENST00000503313ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344721NR3C2chr4149356256-ENST00000366933SPATA17chr1218036116+6690193212034677

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344721ENST00000366933NR3C2chr4149356256-SPATA17chr1218036116+0.000283080.99971694

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Fusion Genomic Features for NR3C2-SPATA17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NR3C2chr4149356255-SPATA17chr1218036115+4.75E-060.99999523
NR3C2chr4149356255-SPATA17chr1218036115+4.75E-060.99999523

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NR3C2-SPATA17


check button Go to

FGviewer for the breakpoints of chr4:149356256-chr1:218036116

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NR3C2

P08235

.
FUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28603_668585.6666666666666868.0DNA bindingNuclear receptor
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28726_964585.6666666666666868.0DomainNR LBD
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-281_602585.6666666666666868.0RegionNote=Modulating
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28669_725585.6666666666666868.0RegionNote=Hinge
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28782_785585.6666666666666868.0RegionNote=Important for coactivator binding
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28603_623585.6666666666666868.0Zinc fingerNR C4-type
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28639_663585.6666666666666868.0Zinc fingerNR C4-type
TgeneSPATA17chr4:149356256chr1:218036116ENST0000036693381132_61335.01879.3333333333333DomainIQ 1
TgeneSPATA17chr4:149356256chr1:218036116ENST0000036693381155_84335.01879.3333333333333DomainIQ 2
TgeneSPATA17chr4:149356256chr1:218036116ENST0000036693381191_120335.01879.3333333333333DomainIQ 3


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Fusion Gene Sequence for NR3C2-SPATA17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000344721_ENST00000366933_TCGA-W5-AA2T-01A_NR3C2_chr4_149356256_-_SPATA17_chr1_218036116_length(transcript)=6690nt_BP=1932nt
ATTGCTCTACCCACCGTCAGCAGGGCGACTGCCACTGCCGGGATTATCATCCTCTCCATCCTCACCGCCGATCAGCCAATATTGGACTTG
CTGGTGGCGGCGGCAGCAGCGGCGGCGGGAGTCTAGCCGTTCCCCTTCCCCCGCCCCAGCCTCCCCACCATGTCCTAGAAAAGCGATGGA
GACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGTCAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGG
ACCTACAGAGAGGACCGATGAGAATAACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACTCAAGG
AAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGGCCTGGGATTTTAACATCTGATATTAAAACTGAGCT
GGAATCTAAGGAACTTTCAGCAACTGTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAGCAGCA
GAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTGGTGAAATTTTACAAAGGAAATGGCCATCGTCCTTC
CACTCTAAGTTGTGTGAACACGCCCTTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCGTTGTTAA
AAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATGACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTC
TGTGTCCTCCACCACAGCCAGCTTTGGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAATGTTGA
AAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCTCTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAAT
TTCCAGCCCTCCAAGTCACTGCAGTGTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCTGCAAA
TATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCCACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATC
TATCTGTAGCCCTGTAAACAATGCCTTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCCAGTCC
AGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTAGAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCT
TAATATTGTCCAGTACATAAAACCAGAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGATTCTTC
ATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCTTTTAAAGGGAATCCAACAGTAAACCCGTTTCCATT
TATGGATGGCTCGTATTTTTCCTTTATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTTGATGG
TAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGATGGGAGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGC
TATTGTTGGGGTGAATTCAGGTGGACAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGAGACCA
ATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGGAAATCACACGGCGACCTGTCGTCTAGAAGAAGTGA
TGGGTATCCGGTCTTAGAATACATTCCAGAAAATGTATCAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGTATGGA
AAATTATATTCAAAAGCTGGACAGATTGTATAAAGGCGTCAGAAGAAGAAACTGAAGCCATCTGCATTTTAAAACTTAACAGTTCTGAAA
GGAAAACACAGATGAAGATCCTGTAGGAAATATACTTGCTATGATTCAATAAACTATAAAATTTTGTAGCTCTAGTCATGAATTAATTAT
TGTGTGTATGTATTTGAAATCTCTTAGACATATCTTTTCAAACAAATACTTAAACTTGAGTCTGTTACCTCTGAGAATGTCTGTCACAAT
CACAGCCCCTGGTGACCAACAGTGCCATAAATGGTTCCCCTGAAATACCCATATTCTGACCCCATCACCCGGGTCACAAATGATGACACC
AGTGCTGGGTACCCAAATTAAGGGCGACTAACATGTAAGTAGGATGATGAATGGTTTGAAGTGTAAATTGTGTGAAATAGTTCAGCATGA
AAGCTCTGCCCTGAGAAATAATGACTGATTATACCAGTTAGAAACCCTTCAGACTGTTGAACTTGAGACACACAGACACAACAGACACAG
ACTAGTGGGTGTGGGAGCAGAAGCATAGGCACTCTCAAATAGAGAAGACATTTGCAAGTCTCTGCTGCCAAGGGAGCAAAGAGATAATCT
CGATGCCAGGGCTGTGTCAGATCCTGCATGGCTCTGAACTACAGTTGGTTTCCAAAAAGCTGGGCTTTTGTGAGGTTTCTGTTTTTTATG
CGATGCTTAGATTTTCCTGGAATCCTTGGAAGTTAACTCAACATTTGAGGTTCCTATATCCTTTAATCCCATCCCATGTGTATCTTTACA
ATAAAACTTCCTGCTAGAGGTATCCTGAGGGAATCTTTGTTTCTTGCATCTGAAGAGAATAACACTAAACTTATTGCATATGATTTGGGG
GTTGGATCCAATGATAGCACAGAGGGACAGGAAATGTGATTTATTGACCATAAAAGCTTTAATTTAAAATTGCTGGCCAGCGAAATCCAG
ACTCTGGGAAATGTTATAGGCCAAATGATCTGTTTCTTCAACAAATAAATTACAAAACTGAGGGGAAAAAAAGGAACCTATTAAAAAGAC
ATTATCTATCAATCACTGTGTGTGTACAGTTTTGAGCTCCTGATTTAAATAAACAAATTGTAAAATAAAAGATCTTTTGAAACAATTGGA
AGTTTGAACACTGATTGGATATTGGTGGTATAAAAGAATTATTGGTTTTTTTTAGGTGTCATGGTATTGTTTTGGTTTACAAAGTTATAG
ATATAAATGTTGAAATATTTACAGATGCAGTGATATGTTGGCTGGGATTTAATTTGAAAGTCAAAGAAGTGAGTTAAAATACATATACTC
CTCCTCTTATAATCGGTTATGTGCCAATAAATCCATTGTAAATTGAAAATATCCTAAGTTGAAAATATTGTAAGTTAAAAATGCATTTAA
TACAGCTAACTTACCAGACAGCTTAGCTTAGCCTCACCTACCTTAAATATGCTCAGAACACATACGTTAGCCTATAGTTGGGCAAAATCA
TCTAACACAAAGCCTATTTTATAATATTGAACAGCCCATGTAATTTATTGAATATTGTACTAAAAGTGAAAAACTGAATAGTTGTATGCA
TACTCAAAGTATGGTTTCTACTGAATGCATTGTAAACCAGAAAGTATCTGAGACAATGTTTTTTTTTTTTTTTTTTTTTTTTTTAATTTC
TGAGACAGAGTCTCATTCTGTCACCCAGGTTGGAGTGCAGTGGCATGAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCAGTC
CTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGGGCCAACAAGCCTGGCTAAATATTTTGTACTTTTGGTAGACACGGGTTT
TTACCATGTTGTGCAGGCTGGTCTTGAACGCCTGAGCTCAAGTGATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTACAGGCATGAG
TCACTGAACCCAGCCCTGAGACATGTCTCAATTAGTTTAGAAGTTTATTTGGCCAAGGTTAAGGACATGCCCTTGACACTGCACCTGTCA
GTACAGGTCCTGACAACATGTGTCCAAGGTGGTCAAGCTATACAACTTGGTTTTATACATTTTAAGGAGACATAAGACATCAATAAATAC
ATGGAAGATGTACATTGGTTCAGTCTGGAAAGGCAGGATGCCTCAAACTTGAAACAAGAGAATGGGGGGTGGGAGGATGTGGGAGATGCT
TCCAGGTCATAGTTGGAGTCAAAGACTTTCCAATTGGCAATTGGTTCAAAGAATTTATCTAAAGACCTGGAATCCATAGAAGGCTTTACC
TGGATTAAAATAAGGGGACCAAGGTTCTCATGCAGATGAAGCCTCCAGGTGGCAGACTTCAGAGAGCATAGATTGTAAATGTTTCTTATC
TGACTTAAAAAGGTGTCAGACTCTTAGTAAATTATCTCCTGGATCAGTGAAAAGATGTGAAAAAAGGTTCTCTACAGAATGTAGATTTTC
CCCATAAGAGATAGCTTCGCAGGGCCATTGCAAAATATGTCAAAAATATATATTTTAGGGTAAAATGCCTCAATTTATTTCAAGGCCTGA
TATTTGTCATGTGATGCTATACTACAGTCAGGCTGAAACTTGGCATCTTATTGCTATGAAAAATCTTAAGATCTCTATTTTAATGTTAAT
GCTGGTCACTGGTGCCTGAATTCCAAAGGGAGGAGGGTATAATGAAGCATGTCCAATTCCCCATGCCCCACCCCCACCCCCACATCCTAT
AATGGCCTGAACTAGTTTTTCAGGTTAACTTTGGAATACCCTTGGCCAAGAAGAGGGGTCCATGCAGATGTTTGGAGGGGGGGGTCTTAA
AGCTTTATTTTTAGATTACAGCATATTGCTTTTGCACTATCATAAAGTAAAAACATCATAAGTCAAGCCACCATAAATAGCGGACCATCT
GTATATCTGAAAGAAGATGAACCAAGACTTGGTTATTGTTAAAGCTGATGATTGGCTGTATGAAGATTTACTATACAATTTTGTGTACTT
TTGTAAGTTCTTGGTTGTTTCTAAACTTATAACAAAATAAATAATTGGCCATCTTCATTGGATTGTGAAGCCATTTCCTCCCACATGTTC
GTAAAAATGGTAGCCATGGCCCCTGACTGAACCCAGGTATGAATGGCCTTCATTGATTTTGTAGACCCTGACCTTCTCTGTTCTTCCAGA
GAAGGTGGTACTCAGATAAAAACTTTGAAGCATTTTATTGTTCAGAATATGACTTTGATCTTCTCATAAGACTCAAGTTTTTGAATGCTT
AAGGCTCTTTATCGCTAGTGTATGTAAGTAATATCATTGTCCTTAACCACCATCTGCCTCTCCCCCCAGACACACATAAGTTTATGATAA
CTACAGAGGTGTCCAGATGAGTAAAAACTGCCTTTGCATTAAGGTGAGAGAAGACCGAGATGAAATCTTATTAGAAAATATAACTGGGGA
AAGCAGTTTGTCTGTTTCTCCTGGAAAACTACTAGACTACATCAACTTATATACTACTTCTTTTCTATATTCTCAATATGAGCCACTTAA
GAAAATTAATGAGACTTTATGTTTGACCAAAGCTGGTAATTCCTTGATCTTATTCTCCAAACTTGATTCTGAATGACTACTGACCACTAA
AAACACTAAGAGTACCACTGTGGATGTTTAAAAACATACACCCTAAGAGCCTTCAGAATTAGACGCTTCAATTCTTCTGAAATCAAAAGT
CACACCAGCTTTGCTGTAGTTAATCAGGTAATACCTTTCTTCTCCACTACTCTCTAATTTCCTTGAGGGCAAATATTGTCTTTCTTGATA
AATGCCCTGGACCCAACATCTAACAGAATACCTGGCATAAAGTGAAATCCATCGAATGTGCTAATGATAAATAAAGAAGTTCAAAAAAAT
CTTTTAATAGAAGCTATAAAATAGCAGATAAGCTAAGTCATTCTCATAAAACACCATTTGTCATTTGAATGCGTGCATTGTGGCCTGTTA
CTTTTAACTAGTCTCACTAATTTATAGTTATATATGATGTAGATCTAGATTGTGATGTACACTAAGTGGGTTGATCCTGAGATCAAGCTA
TGATTGCTGCTTGCGTAAAGTGTTCCTTTTGGGAAATAAATAATCTTTCATATCTGTAAACTTTGGTATAATTGGTTATTTATGCAATGT
ATTGTTGTGGTTGTCAACTCAAGATTGTATTCTCATCTGGGGACATTATGAATCTTGTTATTTTATCCCCTTTTTTGCTCTGTTTTTTCA
CATTTATGGCCTACCTGTTACAGCTGCACGGTATCCATTTTCTGTGCTAAATTCATCTTTAATTTATTATTTTTTTTCAACCTCAGCTTT
TAACTTTGCCCTGATTTTCTCTTCCATTTTATTTTCACTTCCATTTTAAGCTGGCTCAAAGCCTTTTAGGAACAATAAGTTACTGAATTA
TATGAACCTATTTGAGGTAATGATGATGCCTGGGAAGGAGCAGTATTGCTGGATCAGAATTCACTTTTTCCAAGTTACAGATTTTAATAA
ACCACTGTGCAAAGCATTAGGATAAATTTTTATTGAAAATTGAGTGAATGACTGAACAAATCGCTGGGTAATGCTGTTTAGGTTGTTCTA

>In-frame_ENST00000344721_ENST00000366933_TCGA-W5-AA2T-01A_NR3C2_chr4_149356256_-_SPATA17_chr1_218036116_length(amino acids)=677AA_start in transcript=1_stop in transcript=2034
LLYPPSAGRLPLPGLSSSPSSPPISQYWTCWWRRQQRRRESSRSPSPAPASPPCPRKAMETKGYHSLPEGLDMERRWGQVSQAVERSSLG
PTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQ
NQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINS
VSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPAN
INNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQL
NIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDG
NCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NR3C2-SPATA17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NR3C2-SPATA17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNR3C2P08235DB00421SpironolactoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00421SpironolactoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00421SpironolactoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00588Fluticasone propionateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00588Fluticasone propionateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00588Fluticasone propionateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00700EplerenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00700EplerenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB00700EplerenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB01013Clobetasol propionateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB01013Clobetasol propionateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB01013Clobetasol propionateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB01395DrospirenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB01395DrospirenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB01395DrospirenoneAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB06780Desoxycorticosterone acetateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB06780Desoxycorticosterone acetateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB06780Desoxycorticosterone acetateAgonistSmall moleculeApproved
HgeneNR3C2P08235DB08906Fluticasone furoateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB08906Fluticasone furoateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB08906Fluticasone furoateAntagonistSmall moleculeApproved
HgeneNR3C2P08235DB13943Testosterone cypionateSmall moleculeApproved
HgeneNR3C2P08235DB13943Testosterone cypionateSmall moleculeApproved
HgeneNR3C2P08235DB13943Testosterone cypionateSmall moleculeApproved
HgeneNR3C2P08235DB13944Testosterone enanthateSmall moleculeApproved
HgeneNR3C2P08235DB13944Testosterone enanthateSmall moleculeApproved
HgeneNR3C2P08235DB13944Testosterone enanthateSmall moleculeApproved
HgeneNR3C2P08235DB13867FluticasoneAntagonistSmall moleculeApproved|Experimental
HgeneNR3C2P08235DB13867FluticasoneAntagonistSmall moleculeApproved|Experimental
HgeneNR3C2P08235DB13867FluticasoneAntagonistSmall moleculeApproved|Experimental
HgeneNR3C2P08235DB00393NimodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00393NimodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00393NimodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00624TestosteroneLigandSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00624TestosteroneLigandSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00624TestosteroneLigandSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00687FludrocortisoneAgonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00687FludrocortisoneAgonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00687FludrocortisoneAgonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB01023FelodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB01023FelodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB01023FelodipineAntagonistSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneNR3C2P08235DB00396ProgesteroneAgonist|AntagonistSmall moleculeApproved|Vet_approved
HgeneNR3C2P08235DB00396ProgesteroneAgonist|AntagonistSmall moleculeApproved|Vet_approved
HgeneNR3C2P08235DB00396ProgesteroneAgonist|AntagonistSmall moleculeApproved|Vet_approved
HgeneNR3C2P08235DB01134Desoxycorticosterone pivalateAgonistSmall moleculeExperimental|Vet_approved
HgeneNR3C2P08235DB01134Desoxycorticosterone pivalateAgonistSmall moleculeExperimental|Vet_approved
HgeneNR3C2P08235DB01134Desoxycorticosterone pivalateAgonistSmall moleculeExperimental|Vet_approved

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Related Diseases for NR3C2-SPATA17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNR3C2C1449842Pseudohypoaldosteronism, Type I, Autosomal Dominant7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNR3C2C0011570Mental Depression5PSYGENET
HgeneNR3C2C0011581Depressive disorder5PSYGENET
HgeneNR3C2C1854631Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNR3C2C0041696Unipolar Depression4PSYGENET
HgeneNR3C2C1269683Major Depressive Disorder4PSYGENET
HgeneNR3C2C0018801Heart failure2CTD_human
HgeneNR3C2C0018802Congestive heart failure2CTD_human
HgeneNR3C2C0023212Left-Sided Heart Failure2CTD_human
HgeneNR3C2C0027051Myocardial Infarction2CTD_human
HgeneNR3C2C0235527Heart Failure, Right-Sided2CTD_human
HgeneNR3C2C1959583Myocardial Failure2CTD_human
HgeneNR3C2C1961112Heart Decompensation2CTD_human
HgeneNR3C2C0007193Cardiomyopathy, Dilated1CTD_human
HgeneNR3C2C0014175Endometriosis1CTD_human
HgeneNR3C2C0242698Ventricular Dysfunction, Left1CTD_human
HgeneNR3C2C0269102Endometrioma1CTD_human
HgeneNR3C2C1449563Cardiomyopathy, Familial Idiopathic1CTD_human