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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRG1-LRRC28 (FusionGDB2 ID:59909)

Fusion Gene Summary for NRG1-LRRC28

check button Fusion gene summary
Fusion gene informationFusion gene name: NRG1-LRRC28
Fusion gene ID: 59909
HgeneTgene
Gene symbol

NRG1

LRRC28

Gene ID

3084

123355

Gene nameneuregulin 1leucine rich repeat containing 28
SynonymsARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF-
Cytomap

8p12

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factorleucine-rich repeat-containing protein 28
Modification date2020032020200313
UniProtAcc

Q02297

Q86X40

Ensembl transtripts involved in fusion geneENST00000519301, ENST00000520407, 
ENST00000523079, ENST00000338921, 
ENST00000356819, ENST00000287845, 
ENST00000341377, ENST00000287842, 
ENST00000521670, ENST00000405005, 
ENST00000520502, ENST00000539990, 
ENST00000523681, 		ENST00000558879, 
ENST00000301981, ENST00000422500, 
ENST00000442993, ENST00000447360, 
ENST00000331450, ENST00000559399, 
Fusion gene scores* DoF score12 X 10 X 7=84015 X 11 X 9=1485
# samples 1219
** MAII scorelog2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1485*10)=-2.96639160735718
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRG1 [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRG1(32474403)-LRRC28(99926234), # samples:1
Anticipated loss of major functional domain due to fusion event.NRG1-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

HgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

HgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

HgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

HgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

HgeneNRG1

GO:0051048

negative regulation of secretion

10559227

HgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

HgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check buttonFusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LRRC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FENRG1chr8

32474403

+LRRC28chr15

99926234

+


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Fusion Gene ORF analysis for NRG1-LRRC28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000519301ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000519301ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000519301ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000519301ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000519301ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000519301ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000519301ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520407ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520407ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520407ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520407ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520407ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520407ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520407ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000523079ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000523079ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000523079ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000523079ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000523079ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000523079ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000523079ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000338921ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000338921ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000338921ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000338921ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000338921ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000338921ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000338921ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000356819ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000356819ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000356819ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000356819ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000356819ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000356819ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000356819ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000287845ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000287845ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000287845ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000287845ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000287845ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000287845ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000287845ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000341377ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000341377ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000341377ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000341377ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000341377ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000341377ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000341377ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000287842ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000287842ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000287842ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000287842ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000287842ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000287842ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000287842ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000521670ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000521670ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000521670ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000521670ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000521670ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000521670ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000521670ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000405005ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
Frame-shiftENST00000405005ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
In-frameENST00000405005ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000405005ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000405005ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000405005ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
5CDS-intronENST00000405005ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520502ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520502ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000520502ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520502ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520502ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520502ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000520502ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000539990ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000539990ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000539990ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000539990ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000539990ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000539990ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000539990ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000523681ENST00000558879NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000523681ENST00000301981NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-3CDSENST00000523681ENST00000422500NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000523681ENST00000442993NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000523681ENST00000447360NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000523681ENST00000331450NRG1chr8

32474403

+LRRC28chr15

99926234

+
intron-intronENST00000523681ENST00000559399NRG1chr8

32474403

+LRRC28chr15

99926234

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523079NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000523079NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000338921NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000338921NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000356819NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000356819NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000341377NRG1chr832474403+ENST00000558879LRRC28chr1599926234+119210191541020288
ENST00000341377NRG1chr832474403+ENST00000422500LRRC28chr1599926234+142410191541020288
ENST00000287842NRG1chr832474403+ENST00000558879LRRC28chr1599926234+113596297963288
ENST00000287842NRG1chr832474403+ENST00000422500LRRC28chr1599926234+136796297963288
ENST00000521670NRG1chr832474403+ENST00000558879LRRC28chr1599926234+7836106612220
ENST00000521670NRG1chr832474403+ENST00000422500LRRC28chr1599926234+1015610108611167
ENST00000405005NRG1chr832474403+ENST00000558879LRRC28chr1599926234+6755025532184
ENST00000405005NRG1chr832474403+ENST00000422500LRRC28chr1599926234+9075020503167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523079ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000523079ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000338921ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000338921ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000356819ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000356819ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000341377ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0174875560.9825125
ENST00000341377ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0230941160.9769059
ENST00000287842ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0144494030.98555064
ENST00000287842ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0152277050.98477226
ENST00000521670ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0121106040.98788935
ENST00000521670ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0128970130.9871029
ENST00000405005ENST00000558879NRG1chr832474403+LRRC28chr1599926234+0.0049143940.99508554
ENST00000405005ENST00000422500NRG1chr832474403+LRRC28chr1599926234+0.0040505310.9959494

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Fusion Genomic Features for NRG1-LRRC28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NRG1chr832474403+LRRC28chr1599926234+0.0105068040.98949325
NRG1chr832474403+LRRC28chr1599926234+0.0105068040.98949325

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRG1-LRRC28


check button Go to

FGviewer for the breakpoints of chr8:32474403-chr15:99926234

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRG1

Q02297

LRRC28

Q86X40

FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+51237_128167.33333333333334638.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+51337_128167.33333333333334525.3333333333334DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+51337_128167.33333333333334646.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+51237_128167.33333333333334641.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+51337_128167.33333333333334477.3333333333333DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+51137_128167.33333333333334421.0DomainNote=Ig-like C2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512165_177167.33333333333334638.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513165_177167.33333333333334525.3333333333334Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513165_177167.33333333333334646.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512165_177167.33333333333334641.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111165_1770591.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15165_1770423.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13165_1770.0297.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513165_177167.33333333333334477.3333333333333Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511165_177167.33333333333334421.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512178_222167.33333333333334638.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513178_222167.33333333333334525.3333333333334DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513178_222167.33333333333334646.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512178_222167.33333333333334641.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111178_2220591.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+11137_1280591.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15178_2220423.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+1537_1280423.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13178_2220.0297.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+1337_1280.0297.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513178_222167.33333333333334477.3333333333333DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511178_222167.33333333333334421.0DomainEGF-like
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+51220_242167.33333333333334638.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512266_640167.33333333333334638.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+51320_242167.33333333333334525.3333333333334Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513266_640167.33333333333334525.3333333333334Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+51320_242167.33333333333334646.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513266_640167.33333333333334646.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+51220_242167.33333333333334641.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512266_640167.33333333333334641.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+11120_2420591.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111266_6400591.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+1520_2420423.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15266_6400423.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+1320_2420.0297.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13266_6400.0297.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+51320_242167.33333333333334477.3333333333333Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513266_640167.33333333333334477.3333333333333Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+51120_242167.33333333333334421.0Topological domainExtracellular
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511266_640167.33333333333334421.0Topological domainCytoplasmic
HgeneNRG1chr8:32474403chr15:99926234ENST00000287842+512243_265167.33333333333334638.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000341377+513243_265167.33333333333334525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000356819+513243_265167.33333333333334646.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000405005+512243_265167.33333333333334641.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000519301+111243_2650591.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000520407+15243_2650423.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000520502+13243_2650.0297.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000521670+513243_265167.33333333333334477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32474403chr15:99926234ENST00000523079+511243_265167.33333333333334421.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810112_133343.6666666666667368.0RepeatNote=LRR 5
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810135_156343.6666666666667368.0RepeatNote=LRR 6
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810158_180343.6666666666667368.0RepeatNote=LRR 7
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181016_36343.6666666666667368.0RepeatNote=LRR 1
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810181_202343.6666666666667368.0RepeatNote=LRR 8
TgeneLRRC28chr8:32474403chr15:99926234ENST00000301981810204_226343.6666666666667368.0RepeatNote=LRR 9
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181042_63343.6666666666667368.0RepeatNote=LRR 2
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181066_87343.6666666666667368.0RepeatNote=LRR 3
TgeneLRRC28chr8:32474403chr15:99926234ENST0000030198181089_110343.6666666666667368.0RepeatNote=LRR 4
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079112_133290.3333333333333313.0RepeatNote=LRR 5
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079135_156290.3333333333333313.0RepeatNote=LRR 6
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079158_180290.3333333333333313.0RepeatNote=LRR 7
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607916_36290.3333333333333313.0RepeatNote=LRR 1
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079181_202290.3333333333333313.0RepeatNote=LRR 8
TgeneLRRC28chr8:32474403chr15:99926234ENST0000044736079204_226290.3333333333333313.0RepeatNote=LRR 9
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607942_63290.3333333333333313.0RepeatNote=LRR 2
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607966_87290.3333333333333313.0RepeatNote=LRR 3
TgeneLRRC28chr8:32474403chr15:99926234ENST000004473607989_110290.3333333333333313.0RepeatNote=LRR 4


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Fusion Gene Sequence for NRG1-LRRC28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000523079_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1192nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG

>In-frame_ENST00000523079_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000523079_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1424nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG
TCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTG
GAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATT

>In-frame_ENST00000523079_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000338921_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1192nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG

>In-frame_ENST00000338921_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000338921_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1424nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG
TCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTG
GAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATT

>In-frame_ENST00000338921_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000356819_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1192nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG

>In-frame_ENST00000356819_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000356819_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1424nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG
TCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTG
GAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATT

>In-frame_ENST00000356819_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000341377_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1192nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG

>In-frame_ENST00000341377_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000341377_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1424nt_BP=1019nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCG
ATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATT
CAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCG
CATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCAC
CATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGT
ATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGAC
CTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTG
TCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTG
GAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATT

>In-frame_ENST00000341377_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=154_stop in transcript=1020
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000287842_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1135nt_BP=962nt
GTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGAGGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCG
GCGGCGGCTGCCGGACGATGGGAGCGTGAGCAGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACG
CGAGCCGCCAGCGGTGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCG
GACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTC
CCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGT
CTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGC
GGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTG
TGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAA
GATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAA
ATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATA
TGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTAC
TGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGG

>In-frame_ENST00000287842_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=97_stop in transcript=963
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000287842_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1367nt_BP=962nt
GTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGAGGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCG
GCGGCGGCTGCCGGACGATGGGAGCGTGAGCAGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACG
CGAGCCGCCAGCGGTGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCG
GACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTC
CCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGT
CTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGC
GGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTG
TGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAA
GATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAA
ATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATA
TGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTAC
TGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGG
AATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCA
GAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTAT
GTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGAC

>In-frame_ENST00000287842_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=288AA_start in transcript=97_stop in transcript=963
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCET
SSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVS

--------------------------------------------------------------
>In-frame_ENST00000521670_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=783nt_BP=610nt
TCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAG
CGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCG
GAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTC
CTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAA
AATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTG
ATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAA
GGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTG
TGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGA

>In-frame_ENST00000521670_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=220AA_start in transcript=661_stop in transcript=2
MQTLGGAAVSHKTNSCLHEEVFAPSVDTDILMGDSEDTYAPSVEAGIPVMISFDSTMVILAEALSFPNLLITLHIYSPESASDALLMRSS
DFPGFFCILIFCGLFFRFNSFPFLNHLNLREEYSELVSHRRTSLEPAADSWLFISFNRGGKAGLWLPAADSGFLPEPRSFFLPFPLPLPS

--------------------------------------------------------------
>In-frame_ENST00000521670_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=1015nt_BP=610nt
TCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAG
CGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCG
GAGTCCGCGGCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTC
CTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAA
AATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTG
ATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAA
GGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTG
TGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGA
CACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATT
GAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTC
CTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGA

>In-frame_ENST00000521670_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=167AA_start in transcript=108_stop in transcript=611
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK

--------------------------------------------------------------
>In-frame_ENST00000405005_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=675nt_BP=502nt
ATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGC
CAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGT
TCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAA
AAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAAT
GACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCA
GAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCA
CCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCA

>In-frame_ENST00000405005_ENST00000558879_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=184AA_start in transcript=553_stop in transcript=2
MQTLGGAAVSHKTNSCLHEEVFAPSVDTDILMGDSEDTYAPSVEAGIPVMISFDSTMVILAEALSFPNLLITLHIYSPESASDALLMRSS
DFPGFFCILIFCGLFFRFNSFPFLNHLNLREEYSELVSHRRTSLEPAADSWLFISFNRGGKAGLWLPAADSGFLPEPRSFFLPFPLPLPS

--------------------------------------------------------------
>In-frame_ENST00000405005_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(transcript)=907nt_BP=502nt
ATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGC
CAGAGCCCAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGT
TCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAGATACAAAAA
AAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAAT
GACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCA
GAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCA
CCCAGTGTCTGCAGACTTTTGACCTGCTGAGTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCA
GTCCAGCACACTCTTCCATCCTGTCCTGTCCAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAAT
GCCTTCACCCTTCCCCCAAGTTGGAATATATCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGT
CTTTTACAGAAACCATTTAGATTGATGGGCCTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGACTTGATCATCT

>In-frame_ENST00000405005_ENST00000422500_TCGA-JY-A6FE_NRG1_chr8_32474403_+_LRRC28_chr15_99926234_length(amino acids)=167AA_start in transcript=0_stop in transcript=503
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NRG1-LRRC28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRG1-LRRC28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRG1-LRRC28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRG1C0036341Schizophrenia7CTD_human
HgeneNRG1C0005586Bipolar Disorder5PSYGENET
HgeneNRG1C0024809Marijuana Abuse3PSYGENET
HgeneNRG1C0011570Mental Depression2PSYGENET
HgeneNRG1C0011581Depressive disorder2PSYGENET
HgeneNRG1C0006142Malignant neoplasm of breast1CTD_human
HgeneNRG1C0006870Cannabis Dependence1PSYGENET
HgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNRG1C0011616Contact Dermatitis1CTD_human
HgeneNRG1C0018801Heart failure1CTD_human
HgeneNRG1C0018802Congestive heart failure1CTD_human
HgeneNRG1C0019569Hirschsprung Disease1CTD_human
HgeneNRG1C0023212Left-Sided Heart Failure1CTD_human
HgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNRG1C0024121Lung Neoplasms1CTD_human
HgeneNRG1C0026650Movement Disorders1CTD_human
HgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
HgeneNRG1C0030193Pain1CTD_human
HgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneNRG1C0038358Gastric ulcer1CTD_human
HgeneNRG1C0085758Aganglionosis, Colonic1CTD_human
HgeneNRG1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneNRG1C0162351Contact hypersensitivity1CTD_human
HgeneNRG1C0234230Pain, Burning1CTD_human
HgeneNRG1C0234238Ache1CTD_human
HgeneNRG1C0234254Radiating pain1CTD_human
HgeneNRG1C0235527Heart Failure, Right-Sided1CTD_human
HgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
HgeneNRG1C0236804Amphetamine Addiction1CTD_human
HgeneNRG1C0236807Amphetamine Abuse1CTD_human
HgeneNRG1C0242379Malignant neoplasm of lung1CTD_human
HgeneNRG1C0266487Etat Marbre1CTD_human
HgeneNRG1C0458257Pain, Splitting1CTD_human
HgeneNRG1C0458259Pain, Crushing1CTD_human
HgeneNRG1C0678222Breast Carcinoma1CTD_human
HgeneNRG1C0751407Pain, Migratory1CTD_human
HgeneNRG1C0751408Suffering, Physical1CTD_human
HgeneNRG1C0876994Cardiotoxicity1CTD_human
HgeneNRG1C1136382Sclerocystic Ovaries1CTD_human
HgeneNRG1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
HgeneNRG1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNRG1C1458155Mammary Neoplasms1CTD_human
HgeneNRG1C1959583Myocardial Failure1CTD_human
HgeneNRG1C1961112Heart Decompensation1CTD_human
HgeneNRG1C3495559Juvenile arthritis1CTD_human
HgeneNRG1C3661523Congenital Intestinal Aganglionosis1CTD_human
HgeneNRG1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneNRG1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneNRG1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneNRG1C4704874Mammary Carcinoma, Human1CTD_human
TgeneLRRC28C0023893Liver Cirrhosis, Experimental1CTD_human