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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRG1-PROSC (FusionGDB2 ID:59913)

Fusion Gene Summary for NRG1-PROSC

check button Fusion gene summary
Fusion gene informationFusion gene name: NRG1-PROSC
Fusion gene ID: 59913
HgeneTgene
Gene symbol

NRG1

PROSC

Gene ID

3084

11212

Gene nameneuregulin 1pyridoxal phosphate binding protein
SynonymsARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDFEPVB6D|PROSC
Cytomap

8p12

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factorpyridoxal phosphate homeostasis proteinPLP homeostasis proteinproline synthase co-transcribed bacterial homolog proteinproline synthetase co-transcribed bacterial homolog protein
Modification date2020032020200313
UniProtAcc

Q02297

.
Ensembl transtripts involved in fusion geneENST00000519301, ENST00000520407, 
ENST00000523079, ENST00000338921, 
ENST00000356819, ENST00000287845, 
ENST00000341377, ENST00000287842, 
ENST00000521670, ENST00000405005, 
ENST00000520502, ENST00000539990, 
ENST00000523681, 		ENST00000328195, 
Fusion gene scores* DoF score12 X 10 X 7=8406 X 6 X 5=180
# samples 127
** MAII scorelog2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRG1 [Title/Abstract] AND PROSC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRG1(32406344)-PROSC(37630273), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

HgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

HgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

HgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

HgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

HgeneNRG1

GO:0051048

negative regulation of secretion

10559227

HgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

HgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check buttonFusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PROSC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7P1-01ANRG1chr8

32406344

-PROSCchr8

37630273

+


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Fusion Gene ORF analysis for NRG1-PROSC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000519301ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
intron-3CDSENST00000520407ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000523079ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000338921ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000356819ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000287845ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000341377ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000287842ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000521670ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
In-frameENST00000405005ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
intron-3CDSENST00000520502ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
intron-3CDSENST00000539990ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+
intron-3CDSENST00000523681ENST00000328195NRG1chr8

32406344

-PROSCchr8

37630273

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523079NRG1chr832406344-ENST00000328195PROSCchr837630273+27876171541125323
ENST00000338921NRG1chr832406344-ENST00000328195PROSCchr837630273+27876171541125323
ENST00000356819NRG1chr832406344-ENST00000328195PROSCchr837630273+27876171541125323
ENST00000287845NRG1chr832406344-ENST00000328195PROSCchr837630273+27876171541125323
ENST00000341377NRG1chr832406344-ENST00000328195PROSCchr837630273+27876171541125323
ENST00000287842NRG1chr832406344-ENST00000328195PROSCchr837630273+2730560971068323
ENST00000521670NRG1chr832406344-ENST00000328195PROSCchr837630273+2378208108716202
ENST00000405005NRG1chr832406344-ENST00000328195PROSCchr837630273+22701000608202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523079ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0057901480.9942099
ENST00000338921ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0057901480.9942099
ENST00000356819ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0057901480.9942099
ENST00000287845ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0057901480.9942099
ENST00000341377ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0057901480.9942099
ENST00000287842ENST00000328195NRG1chr832406344-PROSCchr837630273+0.0034183140.99658173
ENST00000521670ENST00000328195NRG1chr832406344-PROSCchr837630273+0.003622890.99637705
ENST00000405005ENST00000328195NRG1chr832406344-PROSCchr837630273+0.002395310.9976046

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Fusion Genomic Features for NRG1-PROSC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRG1-PROSC


check button Go to

FGviewer for the breakpoints of chr8:32406344-chr8:37630273

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRG1

Q02297

.
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-112165_17733.333333333333336638.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-113165_17733.333333333333336525.3333333333334Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-113165_17733.333333333333336646.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-112165_17733.333333333333336641.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-111165_1770591.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-15165_1770423.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-13165_1770.0297.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-113165_17733.333333333333336477.3333333333333Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-111165_17733.333333333333336421.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-112178_22233.333333333333336638.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-11237_12833.333333333333336638.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-113178_22233.333333333333336525.3333333333334DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-11337_12833.333333333333336525.3333333333334DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-113178_22233.333333333333336646.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-11337_12833.333333333333336646.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-112178_22233.333333333333336641.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-11237_12833.333333333333336641.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-111178_2220591.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-11137_1280591.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-15178_2220423.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-1537_1280423.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-13178_2220.0297.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-1337_1280.0297.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-113178_22233.333333333333336477.3333333333333DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-11337_12833.333333333333336477.3333333333333DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-111178_22233.333333333333336421.0DomainEGF-like
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-11137_12833.333333333333336421.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-11220_24233.333333333333336638.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-112266_64033.333333333333336638.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-11320_24233.333333333333336525.3333333333334Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-113266_64033.333333333333336525.3333333333334Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-11320_24233.333333333333336646.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-113266_64033.333333333333336646.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-11220_24233.333333333333336641.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-112266_64033.333333333333336641.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-11120_2420591.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-111266_6400591.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-1520_2420423.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-15266_6400423.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-1320_2420.0297.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-13266_6400.0297.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-11320_24233.333333333333336477.3333333333333Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-113266_64033.333333333333336477.3333333333333Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-11120_24233.333333333333336421.0Topological domainExtracellular
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-111266_64033.333333333333336421.0Topological domainCytoplasmic
HgeneNRG1chr8:32406344chr8:37630273ENST00000287842-112243_26533.333333333333336638.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000341377-113243_26533.333333333333336525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000356819-113243_26533.333333333333336646.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000405005-112243_26533.333333333333336641.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000519301-111243_2650591.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000520407-15243_2650423.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000520502-13243_2650.0297.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000521670-113243_26533.333333333333336477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:32406344chr8:37630273ENST00000523079-111243_26533.333333333333336421.0TransmembraneHelical%3B Note%3DInternal signal sequence


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Fusion Gene Sequence for NRG1-PROSC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000523079_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2787nt_BP=617nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCT
CTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGT
TATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAA
GTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTT
ATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCA
TGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTG
CGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTT
TCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCAT
CTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATAC
CAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGG
TCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTA
CAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGAT
ATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGT
GACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAG
GAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAG
GAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGA
TCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAG
CCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGG
AGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATC
TCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGC
CTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTG
TATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGT
CATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGG
TAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGT

>In-frame_ENST00000523079_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=154_stop in transcript=1125
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000338921_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2787nt_BP=617nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCT
CTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGT
TATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAA
GTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTT
ATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCA
TGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTG
CGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTT
TCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCAT
CTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATAC
CAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGG
TCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTA
CAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGAT
ATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGT
GACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAG
GAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAG
GAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGA
TCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAG
CCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGG
AGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATC
TCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGC
CTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTG
TATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGT
CATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGG
TAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGT

>In-frame_ENST00000338921_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=154_stop in transcript=1125
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000356819_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2787nt_BP=617nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCT
CTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGT
TATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAA
GTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTT
ATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCA
TGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTG
CGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTT
TCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCAT
CTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATAC
CAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGG
TCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTA
CAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGAT
ATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGT
GACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAG
GAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAG
GAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGA
TCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAG
CCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGG
AGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATC
TCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGC
CTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTG
TATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGT
CATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGG
TAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGT

>In-frame_ENST00000356819_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=154_stop in transcript=1125
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000287845_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2787nt_BP=617nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCT
CTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGT
TATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAA
GTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTT
ATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCA
TGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTG
CGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTT
TCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCAT
CTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATAC
CAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGG
TCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTA
CAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGAT
ATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGT
GACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAG
GAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAG
GAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGA
TCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAG
CCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGG
AGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATC
TCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGC
CTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTG
TATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGT
CATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGG
TAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGT

>In-frame_ENST00000287845_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=154_stop in transcript=1125
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000341377_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2787nt_BP=617nt
GAGGCCAGGGGAGGGTGCGAAGGAGGCGCCTGCCTCCAACCTGCGGGCGGGAGGTGGGTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGA
GGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGCAG
GACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGCGAGCCGCCAGCGGTGGGACCCATCGACGACTT
CCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGC
AGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGAT
CCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAG
AGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCT
CTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGT
TATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAA
GTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTT
ATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCA
TGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTG
CGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTT
TCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCAT
CTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATAC
CAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGG
TCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTA
CAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGAT
ATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGT
GACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAG
GAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAG
GAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGA
TCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAG
CCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGG
AGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATC
TCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGC
CTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTG
TATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGT
CATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGG
TAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGT

>In-frame_ENST00000341377_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=154_stop in transcript=1125
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000287842_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2730nt_BP=560nt
GTGGCTGCGGGGCAATTGAAAAAGAGCCGGCGAGGAGTTCCCCGAAACTTGTTGGAACTCCGGGCTCGCGCGGAGGCCAGGAGCTGAGCG
GCGGCGGCTGCCGGACGATGGGAGCGTGAGCAGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACG
CGAGCCGCCAGCGGTGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAGCCAGGGCGAGCGCCCGTTCCAGGTGGCCG
GACCGCCCGCCGCGTCCGCGCCGCGCTCCCTGCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTC
CCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAGCGCTCCGT
CTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGC
GGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTG
GCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGA
GACCATAGCCATCGTGGAGCACATAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCT
TAGTCAAGGACCAAATCCAGACTTCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGA
GCTGAGCATGGGCATGTCCGCGGATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCG
GGATTACTCAAAGAAACCCACCCCGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATA
CTGAGAGCACTAACTATGCACTAACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGA
GCACTAATGATCACGTGTGTTGATGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTT
TGAGAAATTCAAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTG
ATCCATGAATGCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTA
ATAGGAAAATTCCTTATGGTTAACATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCC
AGATTCTTCCCTAGCCGGTAGATACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTC
TCAAAACACAAATTGTTGCTGGCCAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGC
CTAGGAGTTCAAGACCAGCCTCAGCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTG
AGGTGGAAGAATGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAA
AAAAAAAATCCCAATAGTCCATGAAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATAT
GCAGATAATACCCCCCAACTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCT
GTTTTATCCCTGAAATTAAAGGATAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCT
GGGACCTACAGTGATGAGAATTTAATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCA
TTACTCCTAAGAAACGAAAGATTCCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAG
CACTTTCCAGGCATAGTTACAGCTTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCC
TCAAAAAACCCAAAAACACCATTCTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTT
ATTTTTTGAAGCCCCAGTCTTTGATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATG
ATTCCTGTATTATTTCAGTGAGAGCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATCTGTGCCAA

>In-frame_ENST00000287842_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=323AA_start in transcript=97_stop in transcript=1068
MPDDGSVSRTVITSPRSGCEGAGQRPGREPPAVGPIDDFPGRQEQPREPGRAPVPGGRTARRVRAALPAGNGRRPRAARAPQRGRSLSPS
RDKLFPNPIRALGPNSPAPRAVRVERSVSGEMSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQR
KGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELS

--------------------------------------------------------------
>In-frame_ENST00000521670_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2378nt_BP=208nt
TCGCTCTCCCCCTCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCGCCGAGAGCCGTCCGCGTAGAG
CGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCG
GAGTCCGCGGCGGGCAGCCAGAGCCCAGCTGTCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAAC
AGTTCCTGGCAGAGAAAAGGTTCTCCTGAAAGGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCA
CCTTCAGAGACCATAGCCATCGTGGAGCACATAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGG
CATGATCTTAGTCAAGGACCAAATCCAGACTTCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGAC
CAGGTTGAGCTGAGCATGGGCATGTCCGCGGATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTT
GGAGAGCGGGATTACTCAAAGAAACCCACCCCGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCC
AGGGAATACTGAGAGCACTAACTATGCACTAACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACC
TGTGGAGAGCACTAATGATCACGTGTGTTGATGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGG
ATTGAGTTTGAGAAATTCAAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGC
ATGAACTGATCCATGAATGCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATC
TCATTTTAATAGGAAAATTCCTTATGGTTAACATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTT
CTGCCCCCAGATTCTTCCCTAGCCGGTAGATACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAG
GTTAATTCTCAAAACACAAATTGTTGCTGGCCAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATC
ACCTGAGCCTAGGAGTTCAAGACCAGCCTCAGCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCAT
GGTGGCTGAGGTGGAAGAATGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTT
AAAAAAAAAAAAAAAATCCCAATAGTCCATGAAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCT
TTTAATATGCAGATAATACCCCCCAACTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACT
GCCACTCTGTTTTATCCCTGAAATTAAAGGATAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTT
TTTCCTCTGGGACCTACAGTGATGAGAATTTAATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGT
GAATCTCATTACTCCTAAGAAACGAAAGATTCCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTC
CTGAGGAGCACTTTCCAGGCATAGTTACAGCTTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAG
CAAGATCCTCAAAAAACCCAAAAACACCATTCTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTT
TTTCTCTTATTTTTTGAAGCCCCAGTCTTTGATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAA
ACATTATGATTCCTGTATTATTTCAGTGAGAGCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATC

>In-frame_ENST00000521670_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=202AA_start in transcript=108_stop in transcript=716
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIA
IVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYS

--------------------------------------------------------------
>In-frame_ENST00000405005_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(transcript)=2270nt_BP=100nt
ATGTCCGAGCGCAAAGAAGGCAGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCGGCGGGCAGC
CAGAGCCCAGCTGTCCCCAATCTCTTCATGCTGGAAACAGTGGATTCTGTGAAGTTGGCAGACAAAGTGAACAGTTCCTGGCAGAGAAAA
GGTTCTCCTGAAAGGTTAAAGGTTATGGTCCAGATTAACACCAGCGGAGAAGAGAGTAAACATGGCCTTCCACCTTCAGAGACCATAGCC
ATCGTGGAGCACATAAACGCCAAGTGTCCTAACCTGGAGTTTGTGGGGCTGATGACCATAGGAAGCTTTGGGCATGATCTTAGTCAAGGA
CCAAATCCAGACTTCCAGCTGTTATTGTCCCTCCGGGAGGAGCTGTGTAAAAAGCTGAACATCCCTGCTGACCAGGTTGAGCTGAGCATG
GGCATGTCCGCGGATTTCCAGCATGCGGTTGAAGTAGGATCTACAAATGTCCGAATAGGAAGCACGATTTTTGGAGAGCGGGATTACTCA
AAGAAACCCACCCCGGACAAGTGCGCAGCAGACGTGAAGGCCCCGCTGGAGGTGGCACAGGAGCACTGAGCCAGGGAATACTGAGAGCAC
TAACTATGCACTAACCTAGATTTTCATTTCGATATTCCCTGTGTCCCAGCGCAGTCCTGCTCTCCTGTGACCTGTGGAGAGCACTAATGA
TCACGTGTGTTGATGGAAACCATCTGTGCTTAGTCTCTGACATAGGAAGCTTGCTTCAGGCAATGGCTTTGGATTGAGTTTGAGAAATTC
AAACATTTCTGCAGAACAGATACCAAATCAATAGCTAGGAATCATGTTCAATATTGAATTCTGCCCAGGAGCATGAACTGATCCATGAAT
GCCTTTTCCAGGTTAAAATTTGGTCACTGATGCCTATAATCGTGGAAGTCAGAGGGATTCCCCTTTTTCATCTCATTTTAATAGGAAAAT
TCCTTATGGTTAACATCTCCCTACAAACTCCTACTACGTCGTCTAAATTGCTGCTCTGGAATAAGGTGATTTCTGCCCCCAGATTCTTCC
CTAGCCGGTAGATACGTGAAGATATTCCCAACTGTGGAATGGCAGTGTAGGTAGCTTCAGGAAATGGCTCAGGTTAATTCTCAAAACACA
AATTGTTGCTGGCCAGGCATGGTGACTCATGCCTGTAATCCCAGCAATTTGGGAGACAGAGGCGGAAGGATCACCTGAGCCTAGGAGTTC
AAGACCAGCCTCAGCAACAGCAGGAGCCCCACCCCCCGTCTCTACAAAAAAATTTAAAAATTAACTGGGCATGGTGGCTGAGGTGGAAGA
ATGGAAGAATCACTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACCACTGTACTCCTGCCTTAAAAAAAAAAAAAAAATC
CCAATAGTCCATGAAGGCTTTGATCTCTTGGGAAGTTCTTCATAGATGCTGTCACATTTCTTAAAGCAACCTTTTAATATGCAGATAATA
CCCCCCAACTTTTTTAGAGACAGCCTGTCTCTTAAAAAAAAAATTAATTTGGTAGTGAGAGCTTGTGTCACTGCCACTCTGTTTTATCCC
TGAAATTAAAGGATAACATAAGGAGGACTTGGGCCTTTCTGACATCATCCTGAAGAGACAGGACTTTGCGTTTTTCCTCTGGGACCTACA
GTGATGAGAATTTAATGATTATCTCCTCCACTATAATCCTCTTTAGGGTGATTTTTTAAATCAAAACCCAGTGAATCTCATTACTCCTAA
GAAACGAAAGATTCCTTCAAAGCCTTTTCAGGCACATGGTTTCAACAAAGCCTGGCTTTGACATTCCTTGTCCTGAGGAGCACTTTCCAG
GCATAGTTACAGCTTCCCCACTGTATTTACAAGCCAGAATTGTGCAACTCTTCTGGATCATTAATAAAGTAGCAAGATCCTCAAAAAACC
CAAAAACACCATTCTCTAATAGTCATGACAAATGGCTTCAGTATGGCTTGTTTTTTATTTTCCAGATGGCTTTTTCTCTTATTTTTTGAA
GCCCCAGTCTTTGATTTTACAGGTAACTTTCAAAACATCATGATGCTGCCAAATGTACTTTTGTAAACTTAAACATTATGATTCCTGTAT
TATTTCAGTGAGAGCTACAGTGTGATATTTCAGAGTCTATTAAATAAAAATGTGAGTTTGAATTACACCATCTGTGCCAATTACAAAGCA

>In-frame_ENST00000405005_ENST00000328195_TCGA-TS-A7P1-01A_NRG1_chr8_32406344_-_PROSC_chr8_37630273_length(amino acids)=202AA_start in transcript=0_stop in transcript=608
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIA
IVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYS

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Fusion Gene PPI Analysis for NRG1-PROSC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRG1-PROSC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRG1-PROSC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRG1C0036341Schizophrenia7CTD_human
HgeneNRG1C0005586Bipolar Disorder5PSYGENET
HgeneNRG1C0024809Marijuana Abuse3PSYGENET
HgeneNRG1C0011570Mental Depression2PSYGENET
HgeneNRG1C0011581Depressive disorder2PSYGENET
HgeneNRG1C0006142Malignant neoplasm of breast1CTD_human
HgeneNRG1C0006870Cannabis Dependence1PSYGENET
HgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNRG1C0011616Contact Dermatitis1CTD_human
HgeneNRG1C0018801Heart failure1CTD_human
HgeneNRG1C0018802Congestive heart failure1CTD_human
HgeneNRG1C0019569Hirschsprung Disease1CTD_human
HgeneNRG1C0023212Left-Sided Heart Failure1CTD_human
HgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNRG1C0024121Lung Neoplasms1CTD_human
HgeneNRG1C0026650Movement Disorders1CTD_human
HgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
HgeneNRG1C0030193Pain1CTD_human
HgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneNRG1C0038358Gastric ulcer1CTD_human
HgeneNRG1C0085758Aganglionosis, Colonic1CTD_human
HgeneNRG1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneNRG1C0162351Contact hypersensitivity1CTD_human
HgeneNRG1C0234230Pain, Burning1CTD_human
HgeneNRG1C0234238Ache1CTD_human
HgeneNRG1C0234254Radiating pain1CTD_human
HgeneNRG1C0235527Heart Failure, Right-Sided1CTD_human
HgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
HgeneNRG1C0236804Amphetamine Addiction1CTD_human
HgeneNRG1C0236807Amphetamine Abuse1CTD_human
HgeneNRG1C0242379Malignant neoplasm of lung1CTD_human
HgeneNRG1C0266487Etat Marbre1CTD_human
HgeneNRG1C0458257Pain, Splitting1CTD_human
HgeneNRG1C0458259Pain, Crushing1CTD_human
HgeneNRG1C0678222Breast Carcinoma1CTD_human
HgeneNRG1C0751407Pain, Migratory1CTD_human
HgeneNRG1C0751408Suffering, Physical1CTD_human
HgeneNRG1C0876994Cardiotoxicity1CTD_human
HgeneNRG1C1136382Sclerocystic Ovaries1CTD_human
HgeneNRG1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
HgeneNRG1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNRG1C1458155Mammary Neoplasms1CTD_human
HgeneNRG1C1959583Myocardial Failure1CTD_human
HgeneNRG1C1961112Heart Decompensation1CTD_human
HgeneNRG1C3495559Juvenile arthritis1CTD_human
HgeneNRG1C3661523Congenital Intestinal Aganglionosis1CTD_human
HgeneNRG1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneNRG1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneNRG1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneNRG1C4704874Mammary Carcinoma, Human1CTD_human