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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRG4-SCNN1D (FusionGDB2 ID:59938)

Fusion Gene Summary for NRG4-SCNN1D

check button Fusion gene summary
Fusion gene informationFusion gene name: NRG4-SCNN1D
Fusion gene ID: 59938
HgeneTgene
Gene symbol

NRG4

SCNN1D

Gene ID

145957

6339

Gene nameneuregulin 4sodium channel epithelial 1 subunit delta
SynonymsHRG4ENaCd|ENaCdelta|SCNED|dNaCh
Cytomap

15q24.2

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-4, membrane-bound isoformheregulin 4pro-NRG4amiloride-sensitive sodium channel subunit deltadelta-ENaCdelta-NaCHepithelial Na(+) channel subunit deltanonvoltage-gated sodium channel 1 subunit deltasodium channel epithelial 1 delta subunitsodium channel, non-voltage-gated 1, delta subunitsodi
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394907, ENST00000535975, 
ENST00000305435, ENST00000563582, 
ENST00000379116, ENST00000338555, 
ENST00000325425, ENST00000467651, 
ENST00000400928, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 3=27
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRG4 [Title/Abstract] AND SCNN1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRG4(76301541)-SCNN1D(1225857), # samples:2
Anticipated loss of major functional domain due to fusion event.NRG4-SCNN1D seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NRG4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SCNN1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J1-01ANRG4chr15

76301541

-SCNN1Dchr1

1225857

+
ChimerDB4ACCTCGA-OR-A5J1-01ANRG4chr15

76301541

-SCNN1Dchr1

1225857

+


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Fusion Gene ORF analysis for NRG4-SCNN1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394907ENST00000379116NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
Frame-shiftENST00000394907ENST00000338555NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
Frame-shiftENST00000394907ENST00000325425NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000394907ENST00000467651NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000394907ENST00000400928NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
Frame-shiftENST00000535975ENST00000379116NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
Frame-shiftENST00000535975ENST00000338555NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
Frame-shiftENST00000535975ENST00000325425NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000535975ENST00000467651NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000535975ENST00000400928NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
In-frameENST00000305435ENST00000379116NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
In-frameENST00000305435ENST00000338555NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
In-frameENST00000305435ENST00000325425NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000305435ENST00000467651NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
5CDS-intronENST00000305435ENST00000400928NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
intron-3CDSENST00000563582ENST00000379116NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
intron-3CDSENST00000563582ENST00000338555NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
intron-3CDSENST00000563582ENST00000325425NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
intron-intronENST00000563582ENST00000467651NRG4chr15

76301541

-SCNN1Dchr1

1225857

+
intron-intronENST00000563582ENST00000400928NRG4chr15

76301541

-SCNN1Dchr1

1225857

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305435NRG4chr1576301541-ENST00000379116SCNN1Dchr11225857+14774394681067199
ENST00000305435NRG4chr1576301541-ENST00000338555SCNN1Dchr11225857+14824394681067199
ENST00000305435NRG4chr1576301541-ENST00000325425SCNN1Dchr11225857+14824394681067199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305435ENST00000379116NRG4chr1576301541-SCNN1Dchr11225857+0.28879890.71120113
ENST00000305435ENST00000338555NRG4chr1576301541-SCNN1Dchr11225857+0.277498160.7225019
ENST00000305435ENST00000325425NRG4chr1576301541-SCNN1Dchr11225857+0.277498160.7225019

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Fusion Genomic Features for NRG4-SCNN1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NRG4chr1576301540-SCNN1Dchr11225856+1.82E-050.9999819
NRG4chr1576301540-SCNN1Dchr11225856+1.82E-050.9999819

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRG4-SCNN1D


check button Go to

FGviewer for the breakpoints of chr15:76301541-chr1:1225857

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000325425915716_802495.3333333333333705.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000338555915716_802429.3333333333333639.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000400928814716_802429.3333333333333639.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000325425915695_715495.3333333333333705.0TransmembraneHelical%3B Name%3D2
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000338555915695_715429.3333333333333639.0TransmembraneHelical%3B Name%3D2
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000400928814695_715429.3333333333333639.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG4chr15:76301541chr1:1225857ENST00000394907-365_4634.666666666666664116.0DomainEGF-like
HgeneNRG4chr15:76301541chr1:1225857ENST00000394907-361_6234.666666666666664116.0Topological domainExtracellular
HgeneNRG4chr15:76301541chr1:1225857ENST00000394907-3684_11534.666666666666664116.0Topological domainCytoplasmic
HgeneNRG4chr15:76301541chr1:1225857ENST00000394907-3663_8334.666666666666664116.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneSCNN1Dchr15:76301541chr1:1225857ENST000003254259151_250495.3333333333333705.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000325425915272_694495.3333333333333705.0Topological domainExtracellular
TgeneSCNN1Dchr15:76301541chr1:1225857ENST000003385559151_250429.3333333333333639.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000338555915272_694429.3333333333333639.0Topological domainExtracellular
TgeneSCNN1Dchr15:76301541chr1:1225857ENST000004009288141_250429.3333333333333639.0Topological domainCytoplasmic
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000400928814272_694429.3333333333333639.0Topological domainExtracellular
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000325425915251_271495.3333333333333705.0TransmembraneHelical%3B Name%3D1
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000338555915251_271429.3333333333333639.0TransmembraneHelical%3B Name%3D1
TgeneSCNN1Dchr15:76301541chr1:1225857ENST00000400928814251_271429.3333333333333639.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for NRG4-SCNN1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000305435_ENST00000379116_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(transcript)=1477nt_BP=439nt
GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG
AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT
CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA
GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT
GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC
TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC
ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA
CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG
CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT
TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC
ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG
CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC
AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG
AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG
AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT
GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC

>In-frame_ENST00000305435_ENST00000379116_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(amino acids)=199AA_start in transcript=468_stop in transcript=1067
METHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMG
SLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLA

--------------------------------------------------------------
>In-frame_ENST00000305435_ENST00000338555_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(transcript)=1482nt_BP=439nt
GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG
AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT
CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA
GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT
GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC
TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC
ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA
CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG
CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT
TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC
ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG
CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC
AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG
AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG
AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT
GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC

>In-frame_ENST00000305435_ENST00000338555_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(amino acids)=199AA_start in transcript=468_stop in transcript=1067
METHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMG
SLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLA

--------------------------------------------------------------
>In-frame_ENST00000305435_ENST00000325425_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(transcript)=1482nt_BP=439nt
GAGCTGGGCAGGGGGCGGAGGCGGGGGCTCGGCTGTCTCCGGGGCTGCCACGCAGAGCGGGCTTCGTGGCGTGGACTAAAAGTGAATCAG
AAAAATAAAGAACCAGCATCAAATTTGAAGTGGCCACAAATTCTATTAAAGCAGAAGAAATAGTGGTGAACCATAAAAGAGAACCAGTTT
CCTCTCTATTCTGCAATTTAGAGGAAAAATTTTCATCCAAGGACAGATCAGGTGGTGGACCTAGATGGGAAACCCAAATTATAATCAAGA
GATTTCTTGGTACTGTTTTTCAACCCTACTCTCTTGACCAAGAATGAAACTATTTACAAATTAAGATGCCAACAGATCACGAAGAGCCCT
GTGGTCCCAGTCACAAGTCGTTTTGCCTGAATGGGGGGCTTTGTTATGTGATACCTACTATTCCCAGCCCATTTTGTAGGACACTGCTTC
TACCGCCTCTACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGGGAGTCTGCATTCAAGCTCTCC
ACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGATGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGA
CAGAGGAGCAGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCGCCCGTGTACTCGGTGCCGCAG
CTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTTGGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCT
TCTGCCCTCACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGCCCTGCCTCAGGGGCGTCCAGC
ATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGCGGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATG
CTTCCAGGGGTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTGGACACCTGAACCAGACCTGCC
AGGGCTGTGCGATCTCTTGGCCTGGTCCTTGCAGCTGTGGCAGCAGCAGGCTCCCCAGCGGCCCAGGGTGGGCCAGACCAGCAGCCCAGG
AAGCAGCACACGCGGCCGTGGGGAGGCAGGCACCGGGCATGTCGGCGCCTCTGGTCAAACCACCTACACTGCCTGGGGTGGGTCTCAAGG
AGGCCCGGGGCGGAGGGGGGTTCCCGCGTGCACACGAGTGCGGCTGGACGTGCCGACACGCGGTGATGTACCCATGCTCCGTGTGTCTGT
GTCTGCATGTCCACACGTCTGATGCACCTGTGTACGTGTGTCAAGCCTAGCCACCTCAGCTGCAGGGAGGCAGAAGGCAAGGCAGGCCCC

>In-frame_ENST00000305435_ENST00000325425_TCGA-OR-A5J1-01A_NRG4_chr15_76301541_-_SCNN1D_chr1_1225857_length(amino acids)=199AA_start in transcript=468_stop in transcript=1067
METHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMG
SLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NRG4-SCNN1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRG4-SCNN1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRG4-SCNN1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource