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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:NSD1-FGF18 (FusionGDB2 ID:60051) |
Fusion Gene Summary for NSD1-FGF18 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NSD1-FGF18 | Fusion gene ID: 60051 | Hgene | Tgene | Gene symbol | NSD1 | FGF18 | Gene ID | 64324 | 8817 |
Gene name | nuclear receptor binding SET domain protein 1 | fibroblast growth factor 18 | |
Synonyms | ARA267|KMT3B|SOTOS|SOTOS1|STO | FGF-18|ZFGF5 | |
Cytomap | 5q35.3 | 5q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-as | fibroblast growth factor 18 | |
Modification date | 20200321 | 20200315 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000354179, ENST00000439151, ENST00000347982, ENST00000361032, ENST00000511258, | ENST00000274625, | |
Fusion gene scores | * DoF score | 23 X 14 X 17=5474 | 6 X 5 X 4=120 |
# samples | 37 | 5 | |
** MAII score | log2(37/5474*10)=-3.88699825884864 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NSD1 [Title/Abstract] AND FGF18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NSD1(176684152)-FGF18(170876151), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NSD1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11509567 |
Tgene | FGF18 | GO:0001936 | regulation of endothelial cell proliferation | 16756958 |
Tgene | FGF18 | GO:0043406 | positive regulation of MAP kinase activity | 16756958 |
Tgene | FGF18 | GO:1903670 | regulation of sprouting angiogenesis | 16756958 |
Tgene | FGF18 | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor | 16756958 |
Fusion gene breakpoints across NSD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across FGF18 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-AB3A-01A | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
ChimerDB4 | SARC | TCGA-DX-AB3A-01A | NSD1 | chr5 | 176684152 | - | FGF18 | chr5 | 170876151 | + |
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Fusion Gene ORF analysis for NSD1-FGF18 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000354179 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
In-frame | ENST00000439151 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
In-frame | ENST00000347982 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
In-frame | ENST00000361032 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
intron-3CDS | ENST00000511258 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000354179 | NSD1 | chr5 | 176684152 | + | ENST00000274625 | FGF18 | chr5 | 170876151 | + | 5511 | 4319 | 160 | 4692 | 1510 |
ENST00000439151 | NSD1 | chr5 | 176684152 | + | ENST00000274625 | FGF18 | chr5 | 170876151 | + | 6203 | 5011 | 45 | 5384 | 1779 |
ENST00000347982 | NSD1 | chr5 | 176684152 | + | ENST00000274625 | FGF18 | chr5 | 170876151 | + | 5452 | 4260 | 101 | 4633 | 1510 |
ENST00000361032 | NSD1 | chr5 | 176684152 | + | ENST00000274625 | FGF18 | chr5 | 170876151 | + | 5849 | 4657 | 0 | 5030 | 1676 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000354179 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + | 0.000311634 | 0.9996884 |
ENST00000439151 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + | 0.000289459 | 0.9997105 |
ENST00000347982 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + | 0.000292984 | 0.99970704 |
ENST00000361032 | ENST00000274625 | NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876151 | + | 0.000281503 | 0.9997185 |
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Fusion Genomic Features for NSD1-FGF18 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876150 | + | 8.36E-12 | 1 |
NSD1 | chr5 | 176684152 | + | FGF18 | chr5 | 170876150 | + | 8.36E-12 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NSD1-FGF18 |
Go to FGviewer for the breakpoints of chr5:176684152-chr5:170876151 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 323_388 | 1386.3333333333333 | 2428.0 | Domain | PWWP 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 323_388 | 1386.3333333333333 | 2428.0 | Domain | PWWP 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 323_388 | 1552.3333333333333 | 2594.0 | Domain | PWWP 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 323_388 | 1655.3333333333333 | 2697.0 | Domain | PWWP 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1543_1589 | 1655.3333333333333 | 2697.0 | Zinc finger | PHD-type 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1590_1646 | 1655.3333333333333 | 2697.0 | Zinc finger | PHD-type 2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 2207_2421 | 1386.3333333333333 | 2428.0 | Compositional bias | Note=Pro-rich |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 2207_2421 | 1386.3333333333333 | 2428.0 | Compositional bias | Note=Pro-rich |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 2207_2421 | 1552.3333333333333 | 2594.0 | Compositional bias | Note=Pro-rich |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 2207_2421 | 1655.3333333333333 | 2697.0 | Compositional bias | Note=Pro-rich |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1756_1818 | 1386.3333333333333 | 2428.0 | Domain | PWWP 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1890_1940 | 1386.3333333333333 | 2428.0 | Domain | AWS |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1942_2059 | 1386.3333333333333 | 2428.0 | Domain | SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 2066_2082 | 1386.3333333333333 | 2428.0 | Domain | Post-SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1756_1818 | 1386.3333333333333 | 2428.0 | Domain | PWWP 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1890_1940 | 1386.3333333333333 | 2428.0 | Domain | AWS |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1942_2059 | 1386.3333333333333 | 2428.0 | Domain | SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 2066_2082 | 1386.3333333333333 | 2428.0 | Domain | Post-SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1756_1818 | 1552.3333333333333 | 2594.0 | Domain | PWWP 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1890_1940 | 1552.3333333333333 | 2594.0 | Domain | AWS |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1942_2059 | 1552.3333333333333 | 2594.0 | Domain | SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 2066_2082 | 1552.3333333333333 | 2594.0 | Domain | Post-SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1756_1818 | 1655.3333333333333 | 2697.0 | Domain | PWWP 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1890_1940 | 1655.3333333333333 | 2697.0 | Domain | AWS |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1942_2059 | 1655.3333333333333 | 2697.0 | Domain | SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 2066_2082 | 1655.3333333333333 | 2697.0 | Domain | Post-SET |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1952_1954 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1994_1997 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 2020_2021 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 2060_2066 | 1386.3333333333333 | 2428.0 | Region | Note=Inhibits enzyme activity in the absence of bound histone |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1952_1954 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1994_1997 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 2020_2021 | 1386.3333333333333 | 2428.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 2060_2066 | 1386.3333333333333 | 2428.0 | Region | Note=Inhibits enzyme activity in the absence of bound histone |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1952_1954 | 1552.3333333333333 | 2594.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1994_1997 | 1552.3333333333333 | 2594.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 2020_2021 | 1552.3333333333333 | 2594.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 2060_2066 | 1552.3333333333333 | 2594.0 | Region | Note=Inhibits enzyme activity in the absence of bound histone |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1952_1954 | 1655.3333333333333 | 2697.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1994_1997 | 1655.3333333333333 | 2697.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 2020_2021 | 1655.3333333333333 | 2697.0 | Region | Note=S-adenosyl-L-methionine binding |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 2060_2066 | 1655.3333333333333 | 2697.0 | Region | Note=Inhibits enzyme activity in the absence of bound histone |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1543_1589 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1590_1646 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 1707_1751 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 3 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000347982 | + | 14 | 24 | 2118_2165 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 4%3B atypical |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1543_1589 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1590_1646 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 1707_1751 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 3 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000354179 | + | 14 | 24 | 2118_2165 | 1386.3333333333333 | 2428.0 | Zinc finger | PHD-type 4%3B atypical |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1543_1589 | 1552.3333333333333 | 2594.0 | Zinc finger | PHD-type 1 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1590_1646 | 1552.3333333333333 | 2594.0 | Zinc finger | PHD-type 2 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 1707_1751 | 1552.3333333333333 | 2594.0 | Zinc finger | PHD-type 3 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000361032 | + | 10 | 20 | 2118_2165 | 1552.3333333333333 | 2594.0 | Zinc finger | PHD-type 4%3B atypical |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 1707_1751 | 1655.3333333333333 | 2697.0 | Zinc finger | PHD-type 3 |
Hgene | NSD1 | chr5:176684152 | chr5:170876151 | ENST00000439151 | + | 13 | 23 | 2118_2165 | 1655.3333333333333 | 2697.0 | Zinc finger | PHD-type 4%3B atypical |
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Fusion Gene Sequence for NSD1-FGF18 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000354179_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(transcript)=5511nt_BP=4319nt GGCCGGGTAGGGGGTTCGCCTGCGGCCGCGTCTGCTCGGGGCCTGAGGCCTCGAAGACCCCAGCCCAAGCCCCCAGGTTGATGCCGGCCC AGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCCTTTTCCAATCCAGTGAATTTAGATGCCCCTGAAGACAAGGAC AGCCCTTTCGGATGATCCAGATTCCAGTACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTTCACAGGA ATTGCCATTTTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATG GTGGCCCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGT GGAGGCTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACC TGTCCTTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGG ACTTGCAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCC ATTTGAAGACTGCACAAATGATCCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTC TGCAGATGAGAAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACAT ACAATTTGAAGCACATAAAGATGAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCA GGCCTCTAATGAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAA CACTGCAAAGAAAGAATTTGAGACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAA GAATAAACCCCAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCAT TAGTATCTGTACCACTTCTGATGATGGAAGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCC AGATGCTTTCGATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGT AAAAGCAAAACAGAAGCCTCTCATTAGTAACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTC TCAGGTTAATCTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAA CCTGTCATCAAGCATATCCAGTGAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAA GTTCCGAAGTATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTC TTCTGATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAAC CAGGGATTCAAGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGT CAGTGACTCTGGAACATCAAAGCCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAA ATTCAGTACATTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTA CCGGAGTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGA GAAAAAGGGAGATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACC TGGCTTACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCC TTCATCCAAATTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACT GAATCAGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAG TAAAGAGGATCCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCA ATCTGATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGA TGAACTCAATGGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAG ATTTAAAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCA TAGAACTCCTTCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGT TTGTGATAAATCCAGTGCCAGCATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGC TGTGCGGTCAGAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAA AAAACAAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCA GAACAAGCAGGTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTT GGCTCAGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGC CCTTGAGTCTGAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAA TGATTTAGACCCTGGATTTATGCCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAAC TGAATCTTGTGCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCA TGCTGCAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAG GACGGCCACAAGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGG TGGAGGAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTT CCACCTGGAGTGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATG TAAGCAGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCAC TGTTATGCAGAACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGC CCAGCTCCTAGTGGAGACAGACACCTTCGGTAGTCAAGTCCGGATCAAGGGCAAGGAGACGGAATTCTACCTGTGCATGAACCGCAAAGG CAAGCTCGTGGGGAAGCCCGATGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGC TAAGTACTCCGGCTGGTACGTGGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTT CATGAAGCGCTACCCCAAGGGGCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCAC ACACCCTGCCTAGGCCACCCCGCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTA CATGAAAAATAAGGAAGAAGCTCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATA AGGATTTTATTGTTGACTTGAAACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGG AACAGACAACTCTAAACTCGTCCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCT GAAAGGAAAAAAAAAAAAAACAAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATC CTCTGTTCCTGCCCCAAACTCCAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGC GCAGGGAAGGCGTGCCCCTGGGAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGC AGTTCTGGAGGATGCTGCTATCGACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTAT ATATATTATATATATATAAGCTATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAACCAAGTATTACTGCCTCAACAATTAAAAACA >In-frame_ENST00000354179_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(amino acids)=1510AA_start in transcript=160_stop in transcript=4692 MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRR PYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKL DSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFIS GDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDE EKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSA EPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEE CSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHI PIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSG ELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLR GGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQ AELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREA PFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAG HLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASK KMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEEC VQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENN -------------------------------------------------------------- >In-frame_ENST00000439151_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(transcript)=6203nt_BP=5011nt GCTGGCCCGGGAGGGGGCGCGGGGCACGGTTGATGCCGGCCCAGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCC TTTTCCAATCCAGTGAATTTAGATGCCCCTGAAGACAAGGACAGCCCTTTCGGTAATGGTCAATCCAATTTTTCTGAGCCACTTAATGGG TGTACTATGCAGTTATCGACTGTCAGTGGAACATCCCAAAATGCTTATGGACAAGATTCTCCATCTTGTTACATTCCACTGCGGAGACTA CAGGATTTGGCCTCCATGATCAATGTAGAGTATTTAAATGGGTCTGCTGATGGATCAGAATCCTTTCAAGACCCTGAAAAAAGTGATTCA AGAGCTCAGACGCCAATTGTTTGCACTTCCTTGAGTCCTGGTGGTCCTACAGCACTTGCTATGAAACAGGAACCCTCTTGTAATAACTCC CCTGAACTCCAGGTAAAAGTAACAAAGACTATCAAGAATGGCTTTCTGCACTTTGAGAATTTTACTTGTGTGGACGATGCAGATGTAGAT TCTGAAATGGACCCAGAACAGCCAGTCACAGAGGATGAGAGTATAGAGGAGATCTTTGAGGAAACTCAGACCAATGCCACCTGCAATTAT GAGACTAAATCAGAGAATGGTGTAAAAGTGGCCATGGGAAGTGAACAAGACAGCACACCAGAGAGTAGACACGGTGCAGTCAAATCGCCA TTCTTGCCATTAGCTCCTCAGACTGAAACACAGAAAAATAAGCAAAGAAATGAAGTGGACGGCAGCAATGAAAAAGCAGCCCTTCTCCCA GCCCCCTTTTCACTAGGAGACACAAACATTACAATAGAAGAGCAATTAAACTCAATAAATTTATCTTTTCAGGATGATCCAGATTCCAGT ACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTTCACAGGAATTGCCATTTTGTCAACCTAAGAAAAAG TCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTGATCCG TTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGGCTTTTGGAGATCCTTCTGAGAGA GCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCCTTAGGAGAAGAGGGAAACAGAAA GAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTGCAGAACAGTATGATGTTCCCAAG GGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTGAAGACTGCACAAATGATCCTGAG TCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAGATGAGAAGGAAAAGCCTTGCGCT AAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACATACAATTTGAAGCACATAAAGATGAACGG AGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCTCTAATGAACTTTCCAGGATAGCA AATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTGCAAAGAAAGAATTTGAGACTTCA AATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATAAACCCCAACGAAGCCTGGTGTGT GGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTATCTGTACCACTTCTGATGATGGA AGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATGCTTTCGATAGAACAGAGAACATG TTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAGCAAAACAGAAGCCTCTCATTAGT AACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGGTTAATCTCTCTGATCTGAAGGCA TCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAACCTGTCATCAAGCATATCCAGTGAGAAC TCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCCGAAGTATAAAGTGCAAACACAAA GAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTGATACCAAAGGCTCTCCTTTGGCC AGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGGATTCAAGTGACATAGAAACAGCA GTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTGACTCTGGAACATCAAAGCCATCA AAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCAGTACATTGCTAATGATGTTGAAA GATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGAGTCCTGGTCGTGGGGACTGTTCT ACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAAAGGGAGATGGCACTCAGAACTCC GCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCTTACTGTCCGACAAGAGAGACCTC CCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCATCCAAATTGCGAGATGCTTTTTCA GCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATCAGCTTCCAAGTGTGACTCTTGAT GCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAGAGGATCCCCTTCAGATAATGGGC CACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTGATCCTGGTAAAATTTCTGAAAAA GGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAACTCAATGGTGTAAATCAAGTGGTG CCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAGATTTAAAGAGAAAGAAAACTCTGAGTGT GCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAACTCCTTCAGCAAGCATACTTGAG GAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTGATAAATCCAGTGCCAGCATTGGT GACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGCGGTCAGAGAAGAAACGCCTTAGG AAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAAAAAACAAAAGAAGGTACAGGAGCAGGTG CACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACAAGCAGGTGGACGAGAATTCTTTG ATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTCAGTCAGAACTTGGAGGTGGACAT GCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTGAGTCTGAGGAATTGCTAGTTAAA ACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAATGATTTAGACCCTGGATTTATGCCCAAG AAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAATCTTGTGCCACATCTTATTCAAAA GATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTGCAGCCAAGATGCAGTGTAAAAAA GTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGGCCACAAGCCCCAAGGAGACTGTT GAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAGGAGCTGCACTCAAGGAGAATGTC TGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACCTGGAGTGCCTTGGATTGACTGAG ATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATGTAAGCAGAGTGGGGAAGATGTTAAAAGG TGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTATGCAGAACAAGGGCTTCCGGTGC TCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGCCCAGCTCCTAGTGGAGACAGACACCTTC GGTAGTCAAGTCCGGATCAAGGGCAAGGAGACGGAATTCTACCTGTGCATGAACCGCAAAGGCAAGCTCGTGGGGAAGCCCGATGGCACC AGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGCTAAGTACTCCGGCTGGTACGTGGGCTTC ACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTTCATGAAGCGCTACCCCAAGGGGCAGCCG GAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCACACACCCTGCCTAGGCCACCCCGCCGCGG CCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTACATGAAAAATAAGGAAGAAGCTCTATTT TTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATAAGGATTTTATTGTTGACTTGAAACCCCC GATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGGAACAGACAACTCTAAACTCGTCCCCAGA GGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCTGAAAGGAAAAAAAAAAAAAACAAAAAAA AAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATCCTCTGTTCCTGCCCCAAACTCCAACAAA AATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGCGCAGGGAAGGCGTGCCCCTGGGAATTCT CCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGCAGTTCTGGAGGATGCTGCTATCGACCTT CCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTATATATATTATATATATATAAGCTATTTAT >In-frame_ENST00000439151_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(amino acids)=1779AA_start in transcript=45_stop in transcript=5384 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRP YRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLD SEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISG DISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEE KRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAE PGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEEC SLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIP IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGE LSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRG GAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKP RKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQA ELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAP FLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGH LENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKK MQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV QKYPPTVMQNKGFRCSLHICITCHAANPANVSASKAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNY -------------------------------------------------------------- >In-frame_ENST00000347982_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(transcript)=5452nt_BP=4260nt CCTCCGCCTCCCCTCAGGTTGATGCCGGCCCAGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCCTTTTCCAATCC AGTGAATTTAGATGCCCCTGAAGACAAGGACAGCCCTTTCGGATGATCCAGATTCCAGTACCAGTACATTAGGAAACATGCTAGAATTAC CTGGAACTTCATCATCATCTACTTCACAGGAATTGCCATTTTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATC TCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGTTT CCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGGCTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGT TTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCCTTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGA AAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTGCAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTT CAATCAAGTTGGACAGTGAAGAAGATATGCCATTTGAAGACTGCACAAATGATCCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTT TGAAATCACTGGCTTTTGATTCTGAACATTCTGCAGATGAGAAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATC CAAAAAGGACTAGTGTGAAAAAGGGCCACATACAATTTGAAGCACATAAAGATGAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAA ACTTTATCTCTGGGGATATATCTGATACGCAGGCCTCTAATGAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAG GAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTGCAAAGAAAGAATTTGAGACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGG GTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATAAACCCCAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAG CAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTATCTGTACCACTTCTGATGATGGAAGCAGTGACCTGGATCCCATAGAACACAGCT CAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATGCTTTCGATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGT ATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAGCAAAACAGAAGCCTCTCATTAGTAACTCACATACAGACCACTTAATGGGTTGTA CTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGGTTAATCTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATT TTACAAATGATGCTCTCTCTCCAAAATTCAACCTGTCATCAAGCATATCCAGTGAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAG CTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCCGAAGTATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTA TAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTGATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTC TAAAACTACTGAACAATATGCATGAGAAAACCAGGGATTCAAGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGG AACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTGACTCTGGAACATCAAAGCCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTC AGAATCACATACCTATTGAACCAGACTACAAATTCAGTACATTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGC GGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGAGTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTT TGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAAAGGGAGATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTG CATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCTTACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTG TTACTAGGCGCAACTGTGGACGATCAAAGCCTTCATCCAAATTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTA AAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATCAGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAG GTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAGAGGATCCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTT CTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTGATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAG AGCTGGACTCTGTAATGAACAGTGAGAATGATGAACTCAATGGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAA GGCGCACTAAACCTCGTAAGCGCATGAACAGATTTAAAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTG TGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAACTCCTTCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACT GCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTGATAAATCCAGTGCCAGCATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTT TGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGCGGTCAGAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAG AAGAATATGATCAGATATTTGCTCCTAAGAAAAAACAAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAA GCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACAAGCAGGTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTG AAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTCAGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGC CTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTGAGTCTGAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAA GAAAACCAACTAAGAAACTTCTTGAATCCAATGATTTAGACCCTGGATTTATGCCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCT ATGAAGCTGGTCACCTGGAGAATGGCATAACTGAATCTTGTGCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTG ACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTGCAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTC CAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGGCCACAAGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGC CTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAGGAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGC TGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACCTGGAGTGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAAT GTCGCACAGGAATCCATACCTGTTTTGTATGTAAGCAGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACC ATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTATGCAGAACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTG CTAATCCAGCCAATGTTTCTGCATCTAAAGCCCAGCTCCTAGTGGAGACAGACACCTTCGGTAGTCAAGTCCGGATCAAGGGCAAGGAGA CGGAATTCTACCTGTGCATGAACCGCAAAGGCAAGCTCGTGGGGAAGCCCGATGGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTC TGGAGAACAACTACACGGCCCTGATGTCGGCTAAGTACTCCGGCTGGTACGTGGGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCA AGACCCGGGAGAACCAGCAGGACGTGCATTTCATGAAGCGCTACCCCAAGGGGCAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGG TGACCAAGAGGTCCCGTCGGATCCGGCCCACACACCCTGCCTAGGCCACCCCGCCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACT CCCAGAAAACTGCATCAGAGGAATATTTTTACATGAAAAATAAGGAAGAAGCTCTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAAC TGAACCAAAACTCTTGGGGGGAGGGGTGATAAGGATTTTATTGTTGACTTGAAACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTA GTCAACCCACAGGTGCTTGTCTCTCTCTAGGAACAGACAACTCTAAACTCGTCCCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTG AGAAACCAAAGTCCTTTTTCCCAAAGGTTCTGAAAGGAAAAAAAAAAAAAACAAAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCC CACCAACAAACTCCCCCTAACTTTCCCAATCCTCTGTTCCTGCCCCAAACTCCAACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTA TTGTCCGCTGCAAGCTGCCCCGAGACACCGCGCAGGGAAGGCGTGCCCCTGGGAATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCT CGTCCAATCATGGTGACCCTGCCTTGCTCGCAGTTCTGGAGGATGCTGCTATCGACCTTCCGTGACTCACGTGACCTAGTACACCAATGA TAAGGGAATATTTTAAAACCAGCTATATTATATATATTATATATATATAAGCTATTTATTTCACCTCTCTGTATATTGCAGTTTCATGAA >In-frame_ENST00000347982_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(amino acids)=1510AA_start in transcript=101_stop in transcript=4633 MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRR PYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKL DSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFIS GDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDE EKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSA EPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEE CSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHI PIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSG ELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLR GGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQ AELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREA PFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAG HLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASK KMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEEC VQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENN -------------------------------------------------------------- >In-frame_ENST00000361032_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(transcript)=5849nt_BP=4657nt ATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCCTTTTCCAATCCAGTGAATTTAGATGCCCCTGAAGACAAGGACAGC CCTTTCGGTAATGGTCAATCCAATTTTTCTGAGCCACTTAATGGGTGTACTATGCAGTTATCGACTGTCAGTGGAACATCCCAAAATGCT TATGGACAAGATTCTCCATCTTGTTACATTCCACTGCGGAGACTACAGGATTTGGCCTCCATGATCAATGTAGAGTATTTAAATGGGTCT GCTGATGGATCAGAATCCTTTCAAGACCCTGAAAAAAGTGATTCAAGAGCTCAGACGCCAATTGTTTGCACTTCCTTGAGTCCTGGTGGT CCTACAGCACTTGCTATGAAACAGGAACCCTCTTGTAATAACTCCCCTGAACTCCAGGTAAAAGTAACAAAGACTATCAAGAATGGCTTT CTGCACTTTGAGAATTTTACTTGTGTGGACGATGCAGATGTAGATTCTGAAATGGACCCAGAACAGCCAGTCACAGAGGATGAGAGTATA GAGGAGATCTTTGAGGAAACTCAGACCAATGCCACCTGCAATTATGAGACTAAATCAGAGAATGGTGTAAAAGTGGCCATGGGAAGTGAA CAAGACAGCACACCAGAGAGTAGACACGGTGCAGTCAAATCGCCATTCTTGCCATTAGCTCCTCAGACTGAAACACAGAAAAATAAGCAA AGAAATGAAGTGGACGGCAGCAATGAAAAAGCAGCCCTTCTCCCAGCCCCCTTTTCACTAGGAGACACAAACATTACAATAGAAGAGCAA TTAAACTCAATAAATTTATCTTTTCAGGATGATCCAGATTCCAGTACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCA TCATCTACTTCACAGGAATTGCCATTTGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTGCAGAACAGTATGATGTT CCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTGAAGACTGCACAAATGAT CCTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAGATGAGAAGGAAAAGCCT TGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACTAGTGTGAAAAAGGGCCACATACAATTTGAAGCACATAAAGAT GAACGGAGGGGAAAGATTCCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCTCTAATGAACTTTCCAGG ATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTGTTTTCTTCCTGTGGAAAAAACACTGCAAAGAAAGAATTTGAG ACTTCAAATGGTGACTCTTTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATAAACCCCAACGAAGCCTG GTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAGGAAAAGCGAAGTGATTCCATTAGTATCTGTACCACTTCTGAT GATGGAAGCAGTGACCTGGATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATGCTTTCGATAGAACAGAG AACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTTGCTGCCACAAACACTAGGGTAAAAGCAAAACAGAAGCCTCTC ATTAGTAACTCACATACAGACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGGTTAATCTCTCTGATCTG AAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGATGCTCTCTCTCCAAAATTCAACCTGTCATCAAGCATATCCAGT GAGAACTCGTTAATAAAGGGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCCGAAGTATAAAGTGCAAA CACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAGTGCAGTTTGAAATGCTGCTCTTCTGATACCAAAGGCTCTCCT TTGGCCAGCATTTCTAAAAGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGGATTCAAGTGACATAGAA ACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTACAGATCCTTAGGTGAGGATGTCAGTGACTCTGGAACATCAAAG CCATCAAAACCATTACTTTTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCAGTACATTGCTAATGATG TTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACTGCTCAAAACCTGGTCTCTTACCGGAGTCCTGGTCGTGGGGAC TGTTCTACTAATAGTCCTGTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAAAGGGAGATGGCACTCAG AACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGCGAGTTGTCTGCTTCCCTACCTGGCTTACTGTCCGACAAGAGA GACCTCCCTGCTTCTGGTAAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCATCCAAATTGCGAGATGCT TTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAGACCGAGCGCAAAAGAAAACTGAATCAGCTTCCAAGTGTGACT CTTGATGCTGTACTGCAGGGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAGAGGATCCCCTTCAGATA ATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCATTTCGATAGCAAGGTTAAGCAATCTGATCCTGGTAAAATTTCT GAAAAAGGACTCTCTTTTGAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAACTCAATGGTGTAAATCAA GTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAACCTCGTAAGCGCATGAACAGATTTAAAGAGAAAGAAAACTCT GAGTGTGCCTTTAGGGTCTTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAACTCCTTCAGCAAGCATA CTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCAGCTGGGCCACGGTTAAATGTTTGTGATAAATCCAGTGCCAGC ATTGGTGACATGGAAAAGGAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGCGGTCAGAGAAGAAACGC CTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGATCAGATATTTGCTCCTAAGAAAAAACAAAAGAAGGTACAGGAG CAGGTGCACAAGGTAAGTTCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACAAGCAGGTGGACGAGAAT TCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCTCCGTTTTTGGAGGGCCCCTTGGCTCAGTCAGAACTTGGAGGT GGACATGCTGAGTTGCCGCAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTGAGTCTGAGGAATTGCTA GTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACTAAGAAACTTCTTGAATCCAATGATTTAGACCCTGGATTTATG CCCAAGAAGGGGGACCTTGGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAATCTTGTGCCACATCTTAT TCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGGAAGCGAAAACGACAGAGGCATGCTGCAGCCAAGATGCAGTGT AAAAAAGTGAAAAATGATGACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGGCCACAAGCCCCAAGGAG ACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAAAAAATGCAGGGTGAACGCGGTGGAGGAGCTGCACTCAAGGAG AATGTCTGTCAGAATTGTGAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACCTGGAGTGCCTTGGATTG ACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGAATCCATACCTGTTTTGTATGTAAGCAGAGTGGGGAAGATGTT AAAAGGTGCCTTCTACCCTTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTATGCAGAACAAGGGCTTC CGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCCAATGTTTCTGCATCTAAAGCCCAGCTCCTAGTGGAGACAGAC ACCTTCGGTAGTCAAGTCCGGATCAAGGGCAAGGAGACGGAATTCTACCTGTGCATGAACCGCAAAGGCAAGCTCGTGGGGAAGCCCGAT GGCACCAGCAAGGAGTGTGTGTTCATCGAGAAGGTTCTGGAGAACAACTACACGGCCCTGATGTCGGCTAAGTACTCCGGCTGGTACGTG GGCTTCACCAAGAAGGGGCGGCCGCGGAAGGGCCCCAAGACCCGGGAGAACCAGCAGGACGTGCATTTCATGAAGCGCTACCCCAAGGGG CAGCCGGAGCTTCAGAAGCCCTTCAAGTACACGACGGTGACCAAGAGGTCCCGTCGGATCCGGCCCACACACCCTGCCTAGGCCACCCCG CCGCGGCCCCTCAGGTCGCCCTGGCCACACTCACACTCCCAGAAAACTGCATCAGAGGAATATTTTTACATGAAAAATAAGGAAGAAGCT CTATTTTTGTACATTGTGTTTAAAAGAAGACAAAAACTGAACCAAAACTCTTGGGGGGAGGGGTGATAAGGATTTTATTGTTGACTTGAA ACCCCCGATGACAAAAGACTCACGCAAAGGGACTGTAGTCAACCCACAGGTGCTTGTCTCTCTCTAGGAACAGACAACTCTAAACTCGTC CCCAGAGGAGGACTTGAATGAGGAAACCAACACTTTGAGAAACCAAAGTCCTTTTTCCCAAAGGTTCTGAAAGGAAAAAAAAAAAAAACA AAAAAAAAGAAAAACAAAGAGAAAGTAGTACTCCGCCCACCAACAAACTCCCCCTAACTTTCCCAATCCTCTGTTCCTGCCCCAAACTCC AACAAAAATCGCTCTCTGGTTTGCAGTCATTTATTTATTGTCCGCTGCAAGCTGCCCCGAGACACCGCGCAGGGAAGGCGTGCCCCTGGG AATTCTCCGCGCCTCGACCTCCCGACGACAGACGCCTCGTCCAATCATGGTGACCCTGCCTTGCTCGCAGTTCTGGAGGATGCTGCTATC GACCTTCCGTGACTCACGTGACCTAGTACACCAATGATAAGGGAATATTTTAAAACCAGCTATATTATATATATTATATATATATAAGCT >In-frame_ENST00000361032_ENST00000274625_TCGA-DX-AB3A-01A_NSD1_chr5_176684152_+_FGF18_chr5_170876151_length(amino acids)=1676AA_start in transcript=0_stop in transcript=5030 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTND PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSR IANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSD DGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDL KASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSP LASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMM LKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKR DLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQI MGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENS ECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKR LRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGG GHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSY SKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKE NVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGF RCSLHICITCHAANPANVSASKAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NSD1-FGF18 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NSD1-FGF18 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NSD1-FGF18 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NSD1 | C0175695 | Sotos' syndrome | 20 | CLINGEN;CTD_human;GENOMICS_ENGLAND |
Hgene | NSD1 | C4551477 | SOTOS SYNDROME 1 | 8 | GENOMICS_ENGLAND;UNIPROT |
Hgene | NSD1 | C0004903 | Beckwith-Wiedemann Syndrome | 2 | GENOMICS_ENGLAND |
Hgene | NSD1 | C0265210 | Weaver syndrome | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | NSD1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | NSD1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | NSD1 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
Hgene | NSD1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human;GENOMICS_ENGLAND |
Hgene | NSD1 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
Hgene | NSD1 | C0917816 | Mental deficiency | 1 | CTD_human |
Hgene | NSD1 | C2931574 | Chromosome 5, monosomy 5q35 | 1 | ORPHANET |
Hgene | NSD1 | C3714756 | Intellectual Disability | 1 | CTD_human |
Hgene | NSD1 | C4304526 | 5q35 microduplication syndrome | 1 | ORPHANET |
Tgene | FGF18 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Tgene | FGF18 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | FGF18 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | FGF18 | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
Tgene | FGF18 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | FGF18 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |