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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NT5C2-RPL38 (FusionGDB2 ID:60244)

Fusion Gene Summary for NT5C2-RPL38

check button Fusion gene summary
Fusion gene informationFusion gene name: NT5C2-RPL38
Fusion gene ID: 60244
HgeneTgene
Gene symbol

NT5C2

RPL38

Gene ID

22978

6169

Gene name5'-nucleotidase, cytosolic IIribosomal protein L38
SynonymsGMP|NT5B|PNT5|SPG45|SPG65|cN-IIL38
Cytomap

10q24.32-q24.33

17q25.1

Type of geneprotein-codingprotein-coding
Descriptioncytosolic purine 5'-nucleotidase5'-nucleotidase (purine), cytosolic type BIMP-specific 5'-NTepididymis secretory sperm binding proteinspastic paraplegia 45 (autosomal recessive)60S ribosomal protein L38large ribosomal subunit protein eL38
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000343289, ENST00000404739, 
ENST00000369857, ENST00000423468, 
ENST00000470299, 		ENST00000439590, 
ENST00000311111, ENST00000584577, 
ENST00000534490, ENST00000533498, 
Fusion gene scores* DoF score13 X 8 X 9=93613 X 12 X 3=468
# samples 1713
** MAII scorelog2(17/936*10)=-2.4609737834457
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NT5C2 [Title/Abstract] AND RPL38 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNT5C2(104934615)-RPL38(72205326), # samples:1
Anticipated loss of major functional domain due to fusion event.NT5C2-RPL38 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NT5C2-RPL38 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NT5C2-RPL38 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NT5C2-RPL38 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NT5C2-RPL38 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL38

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across NT5C2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPL38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01ANT5C2chr10

104934615

-RPL38chr17

72205326

+


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Fusion Gene ORF analysis for NT5C2-RPL38

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343289ENST00000439590NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000343289ENST00000311111NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000343289ENST00000584577NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000343289ENST00000534490NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000343289ENST00000533498NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000404739ENST00000439590NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000404739ENST00000311111NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000404739ENST00000584577NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000404739ENST00000534490NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000404739ENST00000533498NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000369857ENST00000439590NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000369857ENST00000311111NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000369857ENST00000584577NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000369857ENST00000534490NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000369857ENST00000533498NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000423468ENST00000439590NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000423468ENST00000311111NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000423468ENST00000584577NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000423468ENST00000534490NT5C2chr10

104934615

-RPL38chr17

72205326

+
intron-3CDSENST00000423468ENST00000533498NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000470299ENST00000439590NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000470299ENST00000311111NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000470299ENST00000584577NT5C2chr10

104934615

-RPL38chr17

72205326

+
Frame-shiftENST00000470299ENST00000534490NT5C2chr10

104934615

-RPL38chr17

72205326

+
In-frameENST00000470299ENST00000533498NT5C2chr10

104934615

-RPL38chr17

72205326

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343289NT5C2chr10104934615-ENST00000439590RPL38chr1772205326+38918929813753
ENST00000343289NT5C2chr10104934615-ENST00000311111RPL38chr1772205326+1164189352861169
ENST00000343289NT5C2chr10104934615-ENST00000584577RPL38chr1772205326+37818929813753
ENST00000343289NT5C2chr10104934615-ENST00000533498RPL38chr1772205326+40518929813753
ENST00000404739NT5C2chr10104934615-ENST00000534490RPL38chr1772205326+4001253457390
ENST00000470299NT5C2chr10104934615-ENST00000439590RPL38chr1772205326+38818829713653
ENST00000470299NT5C2chr10104934615-ENST00000311111RPL38chr1772205326+1163188351860169
ENST00000470299NT5C2chr10104934615-ENST00000584577RPL38chr1772205326+37718829713653
ENST00000470299NT5C2chr10104934615-ENST00000533498RPL38chr1772205326+40418829713653

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343289ENST00000439590NT5C2chr10104934615-RPL38chr1772205326+0.562044260.4379558
ENST00000343289ENST00000311111NT5C2chr10104934615-RPL38chr1772205326+0.588608260.4113917
ENST00000343289ENST00000584577NT5C2chr10104934615-RPL38chr1772205326+0.51216370.48783636
ENST00000343289ENST00000533498NT5C2chr10104934615-RPL38chr1772205326+0.6452850.35471505
ENST00000404739ENST00000534490NT5C2chr10104934615-RPL38chr1772205326+0.821229340.17877065
ENST00000470299ENST00000439590NT5C2chr10104934615-RPL38chr1772205326+0.54773980.45226023
ENST00000470299ENST00000311111NT5C2chr10104934615-RPL38chr1772205326+0.55059310.4494069
ENST00000470299ENST00000584577NT5C2chr10104934615-RPL38chr1772205326+0.51062290.48937708
ENST00000470299ENST00000533498NT5C2chr10104934615-RPL38chr1772205326+0.63045330.3695467

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Fusion Genomic Features for NT5C2-RPL38


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NT5C2chr10104934614-RPL38chr1772205325+6.57E-121
NT5C2chr10104934614-RPL38chr1772205325+6.57E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NT5C2-RPL38


check button Go to

FGviewer for the breakpoints of chr10:104934615-chr17:72205326

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNT5C2chr10:104934615chr17:72205326ENST00000343289-218549_56133.666666666666664562.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNT5C2chr10:104934615chr17:72205326ENST00000404739-117549_56133.666666666666664562.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNT5C2chr10:104934615chr17:72205326ENST00000343289-218202_21033.666666666666664562.0RegionSubstrate binding
HgeneNT5C2chr10:104934615chr17:72205326ENST00000404739-117202_21033.666666666666664562.0RegionSubstrate binding


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Fusion Gene Sequence for NT5C2-RPL38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000343289_ENST00000439590_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=389nt_BP=189nt
GAGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAAT
GTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGC
CTATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTG
ACAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACT

>In-frame_ENST00000343289_ENST00000439590_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=298_stop in transcript=137

--------------------------------------------------------------
>In-frame_ENST00000343289_ENST00000311111_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=1164nt_BP=189nt
GAGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAAT
GTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGC
CTATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTG
ACAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACT
GTATTATATTAAAATACTAAAAATCCTAAGTGTCTTTCGTCTTTGCGGATGGGAAAGGGAAAAATGCTACCTCGTAGTGGCTTCTGATGG
GAACAGGACGCGGGTTCTGTTGCTGCCTTCCTGTGTCTTTTTTTTTTTTTTTTTTTCTTTCTTTGAGACGGAGTCTTGCTCTGTGGCTCA
TCCTGGAGCACAGTGGTGCGATATCAGCTCACTACCACCTCCGCCTCCTGGGTTCAAGCGACTGTCCTGCCTCAGCCTCCCGAGTGGCTG
GGATTACAGGCACACATCACCACGCCTGGCCAATTTTTGTATTTGTAGTAGAGACAGGGTTTCACTGCCTGCCTCAGCCTCCCATAGTGC
TGGGATTACAGGCATGAGCCTCCGTGCCCGGTGCATCCCTAATCTTGAGCATGATCTCAGTCGGCAAATGAGGCCATCTGTTTTCAGCCT
GTTTGAAAATAAGATGTGGGGAGGCCATGATGGAAATAGCACGTGGGGTTAAACATAACTGGCAGATGTGGGAGCGATGGTGGGGCATGC
CATTCAAACAGGTCCCAAAATGGGTGCAACAAGGTATAGCACATCTACCACTCGCTAACTTGACTGACTTGGAGAAATGACTACACTTTT
GCCTGTTTCCTCAGTTGGAAAATAGCCATATTAACACCTCTTTCATTGGCTTGCTGTCAGGGTACTGGGATGGGGGGAGGTGCATGGGTT

>In-frame_ENST00000343289_ENST00000311111_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=169AA_start in transcript=352_stop in transcript=861
MELYYIKILKILSVFRLCGWEREKCYLVVASDGNRTRVLLLPSCVFFFFFFSFFETESCSVAHPGAQWCDISSLPPPPPGFKRLSCLSLP

--------------------------------------------------------------
>In-frame_ENST00000343289_ENST00000584577_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=378nt_BP=189nt
GAGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAAT
GTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGC
CTATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTG
ACAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACTGTATTATAT

>In-frame_ENST00000343289_ENST00000584577_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=298_stop in transcript=137

--------------------------------------------------------------
>In-frame_ENST00000343289_ENST00000533498_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=405nt_BP=189nt
GAGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAAT
GTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGC
CTATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTG
ACAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACT

>In-frame_ENST00000343289_ENST00000533498_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=298_stop in transcript=137

--------------------------------------------------------------
>In-frame_ENST00000404739_ENST00000534490_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=400nt_BP=125nt
AATACAAAATACAGTTAAAATAAAATGTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCAT
GCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAG
ATACCTTTACACCCTGGTCATCACTGACAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTGAGTGAGCCTGAAGTCACTT
CAGGGGCGGGTGGGGTTTGGAAGGTTGCTGTGTGTGGCCATGTTGTATCTTGTTTTGAATCCCTCTCAGATTTCAGAGCCCATTTTATGG

>In-frame_ENST00000404739_ENST00000534490_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=90AA_start in transcript=345_stop in transcript=73
MKSERDSKQDTTWPHTATFQTPPAPEVTSGSLTGGQGLLQFLCLLFVSDDQGVKVSAASNFKLHVVLIFLDLDSDDRLLDDTFSGHAYPC

--------------------------------------------------------------
>In-frame_ENST00000470299_ENST00000439590_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=388nt_BP=188nt
AGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAATG
TCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGCC
TATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTGA
CAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACTG

>In-frame_ENST00000470299_ENST00000439590_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=297_stop in transcript=136

--------------------------------------------------------------
>In-frame_ENST00000470299_ENST00000311111_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=1163nt_BP=188nt
AGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAATG
TCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGCC
TATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTGA
CAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACTG
TATTATATTAAAATACTAAAAATCCTAAGTGTCTTTCGTCTTTGCGGATGGGAAAGGGAAAAATGCTACCTCGTAGTGGCTTCTGATGGG
AACAGGACGCGGGTTCTGTTGCTGCCTTCCTGTGTCTTTTTTTTTTTTTTTTTTTCTTTCTTTGAGACGGAGTCTTGCTCTGTGGCTCAT
CCTGGAGCACAGTGGTGCGATATCAGCTCACTACCACCTCCGCCTCCTGGGTTCAAGCGACTGTCCTGCCTCAGCCTCCCGAGTGGCTGG
GATTACAGGCACACATCACCACGCCTGGCCAATTTTTGTATTTGTAGTAGAGACAGGGTTTCACTGCCTGCCTCAGCCTCCCATAGTGCT
GGGATTACAGGCATGAGCCTCCGTGCCCGGTGCATCCCTAATCTTGAGCATGATCTCAGTCGGCAAATGAGGCCATCTGTTTTCAGCCTG
TTTGAAAATAAGATGTGGGGAGGCCATGATGGAAATAGCACGTGGGGTTAAACATAACTGGCAGATGTGGGAGCGATGGTGGGGCATGCC
ATTCAAACAGGTCCCAAAATGGGTGCAACAAGGTATAGCACATCTACCACTCGCTAACTTGACTGACTTGGAGAAATGACTACACTTTTG
CCTGTTTCCTCAGTTGGAAAATAGCCATATTAACACCTCTTTCATTGGCTTGCTGTCAGGGTACTGGGATGGGGGGAGGTGCATGGGTTG

>In-frame_ENST00000470299_ENST00000311111_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=169AA_start in transcript=351_stop in transcript=860
MELYYIKILKILSVFRLCGWEREKCYLVVASDGNRTRVLLLPSCVFFFFFFSFFETESCSVAHPGAQWCDISSLPPPPPGFKRLSCLSLP

--------------------------------------------------------------
>In-frame_ENST00000470299_ENST00000584577_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=377nt_BP=188nt
AGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAATG
TCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGCC
TATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTGA
CAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACTGTATTATATT

>In-frame_ENST00000470299_ENST00000584577_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=297_stop in transcript=136

--------------------------------------------------------------
>In-frame_ENST00000470299_ENST00000533498_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(transcript)=404nt_BP=188nt
AGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAATG
TCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGCC
TATCATCGCTGTCAAGATCAAGAAAAATAAGGACAACGTGAAGTTTAAAGTTCGATGCAGCAGATACCTTTACACCCTGGTCATCACTGA
CAAAGAGAAGGCAGAGAAACTGAAGCAGTCCCTGCCCCCCGGTTTGGCAGTGAAGGAACTGAAATGAACCAGACACACTGATTGGAACTG

>In-frame_ENST00000470299_ENST00000533498_TCGA-HU-A4GT-01A_NT5C2_chr10_104934615_-_RPL38_chr17_72205326_length(amino acids)=53AA_start in transcript=297_stop in transcript=136

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NT5C2-RPL38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NT5C2-RPL38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NT5C2-RPL38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNT5C2C3888209SPASTIC PARAPLEGIA 45, AUTOSOMAL RECESSIVE5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNT5C2C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneNT5C2C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneNT5C2C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneNT5C2C3714756Intellectual Disability1GENOMICS_ENGLAND