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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NTM-CCDC86 (FusionGDB2 ID:60282)

Fusion Gene Summary for NTM-CCDC86

Fusion gene summary

Fusion gene information	Fusion gene name: NTM-CCDC86
	Fusion gene ID: 60282
		Hgene	Tgene
	Gene symbol	NTM	CCDC86
	Gene ID	50863	79080
	Gene name	neurotrimin	coiled-coil domain containing 86
	Synonyms	CEPU-1\|HNT\|IGLON2\|NTRI	-
	Cytomap	11q25	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	neurotriminIgLON family member 2	coiled-coil domain-containing protein 86cycloncytokine-induced protein with coiled-coil domain
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H6F5
	Ensembl transtripts involved in fusion gene	ENST00000374791, ENST00000539799, ENST00000427481, ENST00000374786, ENST00000425719, ENST00000374784, ENST00000474900,	ENST00000227520, ENST00000545580,
Fusion gene scores	* DoF score	15 X 15 X 7=1575	3 X 3 X 3=27
	# samples	17	3
	** MAII score	log2(17/1575*10)=-3.21174517713694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: NTM [Title/Abstract] AND CCDC86 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NTM(131781542)-CCDC86(60615397), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NTM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC86 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7686-01A	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+

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Fusion Gene ORF analysis for NTM-CCDC86

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000374791	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000374791	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
In-frame	ENST00000539799	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000539799	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
In-frame	ENST00000427481	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000427481	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
In-frame	ENST00000374786	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000374786	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
In-frame	ENST00000425719	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000425719	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
In-frame	ENST00000374784	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
5CDS-5UTR	ENST00000374784	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
intron-3CDS	ENST00000474900	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+
intron-5UTR	ENST00000474900	ENST00000545580	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374791	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1577	496	859	206	217
ENST00000539799	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1248	167	530	0	177
ENST00000427481	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1221	140	503	0	168
ENST00000374786	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1727	646	155	970	271
ENST00000425719	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1268	187	550	2	183
ENST00000374784	NTM	chr11	131781542	-	ENST00000227520	CCDC86	chr11	60615397	+	1262	181	544	2	181

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374791	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.011110979	0.988889
ENST00000539799	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.007022527	0.99297744
ENST00000427481	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.012915633	0.9870843
ENST00000374786	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.029186724	0.9708133
ENST00000425719	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.010664932	0.9893351
ENST00000374784	ENST00000227520	NTM	chr11	131781542	-	CCDC86	chr11	60615397	+	0.012191457	0.98780847

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Fusion Genomic Features for NTM-CCDC86

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NTM-CCDC86

Go to
FGviewer for the breakpoints of chr11:131781542-chr11:60615397
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CCDC86 Q9H6F5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CCDC86

chr11:131781542

chr11:60615397

ENST00000227520

272_323

252.66666666666666

361.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374784

136_218

55.666666666666664

317.0

Domain

Note=Ig-like C2-type 2

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374784

222_309

55.666666666666664

317.0

Domain

Note=Ig-like C2-type 3

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374784

39_126

55.666666666666664

317.0

Domain

Note=Ig-like C2-type 1

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374786

136_218

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 2

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374786

222_309

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 3

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374786

39_126

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 1

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374791

136_218

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 2

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374791

222_309

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 3

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000374791

39_126

55.666666666666664

345.0

Domain

Note=Ig-like C2-type 1

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000425719

136_218

55.666666666666664

356.0

Domain

Note=Ig-like C2-type 2

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000425719

222_309

55.666666666666664

356.0

Domain

Note=Ig-like C2-type 3

Hgene

NTM

chr11:131781542

chr11:60615397

ENST00000425719

39_126

55.666666666666664

356.0

Domain

Note=Ig-like C2-type 1

Tgene

CCDC86

chr11:131781542

chr11:60615397

ENST00000227520

45_200

252.66666666666666

361.0

Compositional bias

Note=Pro-rich

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Fusion Gene Sequence for NTM-CCDC86

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000374791_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1577nt_BP=496nt
AGAGTGTGTGTGCGTGTGTGTGTGTGTGTGTGCCCGCGCGCGTGTGTTGTAGCTCTGTCAATCCTTGGATTAGAACCAATGATTGCAGCT
TGTAGGAGGGCTGTCCAGGGCCAGATTGTACAATGTGTCTCAGTGCCAGAGTATGAGTGGAGATAATTACGGAGAAGTCATACTCTCTCA
CACCCTCGGCTTTCTTGTTGTGTCCTTCAGCAAAACAGTGGATTTAAATCTCCTTGCACAAGCTTGAGAGCAACACAATCTATCAGGAAA
GAAAGAAAGAAAAAAACCGAACCTGACAAAAAAGAAGAAAAAGAAGAAGAAAAAAAATCATGAAAACCATCCAGCCAAAAATGCACAATT
CTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAG
CTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGC
AGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGA
AGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGC
TCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAG
CCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTG
CTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTC
TGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTC
TCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCC
TTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCA
CCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCA
GGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAG
CAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGG

>In-frame_ENST00000374791_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=217AA_start in transcript=859_stop in transcript=206
MVVGHGRPRAVLSSDLGCRLLGRLLLQQGQGVPLLNGAQLLLLCPLELGGVSDHLDDLCLPLILQAAFQVLSPALFLLLAAPLLLLLQVT
GKVLGQLPLLSFLHLPLPRCAQGLVLKHLGESEGGALPLPDRHVVHSFGEGGISAAHGHSLEETQSSQPREDCPRDRIVHFWLDGFHDFF

--------------------------------------------------------------
>In-frame_ENST00000539799_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1248nt_BP=167nt
ATGAAAACCATCCAGCCAAAAATGCACAATTCTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCC
GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG
CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG
GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG
GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG
CTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACAC
AGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGC
TCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAG
ATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGAC
TGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTC
CCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTC
AATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAG
AGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATAC

>In-frame_ENST00000539799_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=177AA_start in transcript=530_stop in transcript=0
MVVGHGRPRAVLSSDLGCRLLGRLLLQQGQGVPLLNGAQLLLLCPLELGGVSDHLDDLCLPLILQAAFQVLSPALFLLLAAPLLLLLQVT

--------------------------------------------------------------
>In-frame_ENST00000427481_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1221nt_BP=140nt
ATGAACGGAAAAAGAAACGGGGAAGGTGGGAAGAGGTGGAAATGGAAGGGCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCC
AAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCG
TGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAG
GAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCC
AAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCG
GCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCC
TCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCA
GGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTC
CTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTAT
GCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTG
AGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGT
TGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCT
ACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTC

>In-frame_ENST00000427481_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=168AA_start in transcript=503_stop in transcript=0
MVVGHGRPRAVLSSDLGCRLLGRLLLQQGQGVPLLNGAQLLLLCPLELGGVSDHLDDLCLPLILQAAFQVLSPALFLLLAAPLLLLLQVT

--------------------------------------------------------------
>In-frame_ENST00000374786_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1727nt_BP=646nt
AACTTACAAAGTGTTGGATGTCCCCCGTTCGAACTGAGGGACTGCAGACCGCCTCTGGGTAGCTGGATGAAGCCCACCCCGTCCCCTTCT
GGTACCAAAGTGCTTACTCCTCTCCAAAGTGCCGTGTCTGAACTGCCGCTGGGAAGAAGCGGCTCCTGAGACGCGCCCACACCTTTCACC
TGCCGCGCGCTTCCCCCTCCTCGGCCACCTTCCCGGCGGAAGCAGCGAGGAGGGAGCCCCCTTTGGCCGTCCTCCGTGGAACCGGTTTTC
CGAGGCTGGCAAAAGCCGAGGCTGGATTTGGGGGAGGAATATTAGACTCGGAGGAGTCTGCGCGCTTTTCTCCTCCCCGCGCCTCCCGGT
CGCCGCGGGTTCACCGCTCAGTCCCCGCGCTCGCTCCGCACCCCACCCACTTCCTGTGCTCGCCCGGGGGGCGTGTGCCGTGCGGCTGCC
GGAGTTCGGGGAAGTTGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGC
TGCTGTTCCTTGTACCCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGG
AGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGA
AGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAAC
GCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCT
CCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGC
CTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCC
AGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTG
GGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACA
TTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCC
TGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGC
AGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTT
TCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATA
CAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAA

>In-frame_ENST00000374786_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=271AA_start in transcript=155_stop in transcript=970
MRRAHTFHLPRASPSSATFPAEAARREPPLAVLRGTGFPRLAKAEAGFGGGILDSEESARFSPPRASRSPRVHRSVPALAPHPTHFLCSP
GGRVPCGCRSSGKLWLSRMGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQR
KMKERQERKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAK

--------------------------------------------------------------
>In-frame_ENST00000425719_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1268nt_BP=187nt
GGAAGTTGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCC
TTGTACCCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCA
CCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCA
AGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGG
AGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGA
AGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGG
CCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGG
ACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGC
AGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGG
TTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTG
ACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAAT
CCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACC
AGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAA
TCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAATAAACAAGC

>In-frame_ENST00000425719_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=183AA_start in transcript=550_stop in transcript=2
MVVGHGRPRAVLSSDLGCRLLGRLLLQQGQGVPLLNGAQLLLLCPLELGGVSDHLDDLCLPLILQAAFQVLSPALFLLLAAPLLLLLQVT
GKVLGQLPLLSFLHLPLPRCAQGLVLKHLGESEGGALPLPDRHVVHSFGEGGISAAHGHSCGYKEQQPERHDHEALPGQEQVPTDPHSRQ

--------------------------------------------------------------
>In-frame_ENST00000374784_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(transcript)=1262nt_BP=181nt
TGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTAC
CCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCA
GATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACT
TTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATG
AGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGG
ACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACA
ACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCC
ACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGAT
GGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTC
AGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTT
GGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTT
CCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTC
TGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAG
GCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAATAAACAAGCAAAATG

>In-frame_ENST00000374784_ENST00000227520_TCGA-HT-7686-01A_NTM_chr11_131781542_-_CCDC86_chr11_60615397_length(amino acids)=181AA_start in transcript=544_stop in transcript=2
MVVGHGRPRAVLSSDLGCRLLGRLLLQQGQGVPLLNGAQLLLLCPLELGGVSDHLDDLCLPLILQAAFQVLSPALFLLLAAPLLLLLQVT
GKVLGQLPLLSFLHLPLPRCAQGLVLKHLGESEGGALPLPDRHVVHSFGEGGISAAHGHSCGYKEQQPERHDHEALPGQEQVPTDPHSRQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NTM-CCDC86

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NTM-CCDC86

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NTM-CCDC86

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NTM	C0041696	Unipolar Depression	1	PSYGENET
Hgene	NTM	C1269683	Major Depressive Disorder	1	PSYGENET
Tgene	CCDC86	C0036341	Schizophrenia	1	PSYGENET
Tgene	CCDC86	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human