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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUBP2-P4HB (FusionGDB2 ID:60366)

Fusion Gene Summary for NUBP2-P4HB

check button Fusion gene summary
Fusion gene informationFusion gene name: NUBP2-P4HB
Fusion gene ID: 60366
HgeneTgene
Gene symbol

NUBP2

P4HB

Gene ID

10101

5034

Gene namenucleotide binding protein 2prolyl 4-hydroxylase subunit beta
SynonymsCFD1|CIAO6|NBP 2|NUBP1CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Cytomap

16p13.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptioncytosolic Fe-S cluster assembly factor NUBP2homolog of yeast cytosolic Fe-S cluster deficient 1nucleotide binding protein 2 (MinD homolog, E. coli)protein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262302, ENST00000565987, 
ENST00000543305, ENST00000565134, 
ENST00000568706, ENST00000568610, 
ENST00000331483, ENST00000576390, 
ENST00000439918, ENST00000472244, 
Fusion gene scores* DoF score3 X 1 X 2=618 X 16 X 10=2880
# samples 221
** MAII scorelog2(2/6*10)=1.73696559416621log2(21/2880*10)=-3.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUBP2 [Title/Abstract] AND P4HB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUBP2(1833037)-P4HB(79813462), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneP4HB

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

7753822


check buttonFusion gene breakpoints across NUBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across P4HB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A4OY-01ANUBP2chr16

1833037

+P4HBchr17

79813462

-


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Fusion Gene ORF analysis for NUBP2-P4HB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262302ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-intronENST00000262302ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-intronENST00000262302ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-5UTRENST00000262302ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-3CDSENST00000565987ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-intronENST00000565987ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-intronENST00000565987ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-5UTRENST00000565987ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-3CDSENST00000543305ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-intronENST00000543305ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-intronENST00000543305ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
5UTR-5UTRENST00000543305ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-
In-frameENST00000565134ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-intronENST00000565134ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-intronENST00000565134ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
5CDS-5UTRENST00000565134ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-3CDSENST00000568706ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-intronENST00000568706ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-intronENST00000568706ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-5UTRENST00000568706ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-3CDSENST00000568610ENST00000331483NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-intronENST00000568610ENST00000576390NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-intronENST00000568610ENST00000439918NUBP2chr16

1833037

+P4HBchr17

79813462

-
intron-5UTRENST00000568610ENST00000472244NUBP2chr16

1833037

+P4HBchr17

79813462

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262302NUBP2chr161833037+ENST00000331483P4HBchr1779813462-216413613700457
ENST00000565134NUBP2chr161833037+ENST00000331483P4HBchr1779813462-20583012642421

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262302ENST00000331483NUBP2chr161833037+P4HBchr1779813462-0.0024387890.9975612
ENST00000565134ENST00000331483NUBP2chr161833037+P4HBchr1779813462-0.0022549960.99774504

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Fusion Genomic Features for NUBP2-P4HB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUBP2-P4HB


check button Go to

FGviewer for the breakpoints of chr16:1833037-chr17:79813462

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneP4HBchr16:1833037chr17:79813462ENST00000331483111349_475117.33333333333333509.0DomainThioredoxin 2
TgeneP4HBchr16:1833037chr17:79813462ENST00000331483111505_508117.33333333333333509.0MotifNote=Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUBP2chr16:1833037chr17:79813462ENST00000262302+1722_295.333333333333333272.0Nucleotide bindingATP
TgeneP4HBchr16:1833037chr17:79813462ENST0000033148311118_134117.33333333333333509.0DomainThioredoxin 1


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Fusion Gene Sequence for NUBP2-P4HB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262302_ENST00000331483_TCGA-EB-A4OY-01A_NUBP2_chr16_1833037_+_P4HB_chr17_79813462_length(transcript)=2164nt_BP=136nt
AAGAAGAGCCACGGGCGGGCACGCACTGCCCATTGGTTGGAAGGCCCTTCGCTCTAGCTGGGAGGCTGACGGCCCGCGGGCGTAAGCGGA
CTGCAGCCGCGAGCTCCTGGAGGCGGCGGGATGGAGGCGGCGGCCGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGC
ACGGGCCCGGCTGCCACCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAG
GACGTGGAGTCGGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTG
TTCTCCAAATACCAGCTCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAG
GAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAA
ATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTC
AAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGC
CCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTC
TGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTT
GTTGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAG
TTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTG
GAGGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACG
CTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAG
CCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGG
GGGCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGA
AGTGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGC
CCACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTC
GCTGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTC
CACCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGT
GTCGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGC
TGGTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTG
ACCACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCT
GGAGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCA

>In-frame_ENST00000262302_ENST00000331483_TCGA-EB-A4OY-01A_NUBP2_chr16_1833037_+_P4HB_chr17_79813462_length(amino acids)=457AA_start in transcript=1370_stop in transcript=0
MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE
AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF
ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE
QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL
GRVRLHVLEEADDSHLAGLHQGLCSCAVRQGGGSRARALLQPVHDVISLSASGRRLHPAASRSSRLQSAYARGPSASQLERRAFQPMGSA

--------------------------------------------------------------
>In-frame_ENST00000565134_ENST00000331483_TCGA-EB-A4OY-01A_NUBP2_chr16_1833037_+_P4HB_chr17_79813462_length(transcript)=2058nt_BP=30nt
CTGGAGGCGGCGGGATGGAGGCGGCGGCCGCTGGCAGAGAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGCTGCCA
CCACCCTGCCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTCTTCAAGGACGTGGAGTCGGACT
CTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGATGACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATACCAGC
TCGACAAAGATGGGGTTGTCCTCTTTAAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACT
TTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCC
TGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGATCCTGT
TCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCA
TCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTTCCTGG
AGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTG
AAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCATTTGGG
ATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGC
ACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAGA
AATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAG
ACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACACCCAGC
AGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTCACCCC
TACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTGGGGCT
TGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCTCCCGC
GGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCAGGCCT
CCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGACTGATC
ATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCCAGCCC
TGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCTCTCTA
CAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATCAGACG

>In-frame_ENST00000565134_ENST00000331483_TCGA-EB-A4OY-01A_NUBP2_chr16_1833037_+_P4HB_chr17_79813462_length(amino acids)=421AA_start in transcript=1264_stop in transcript=2
MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIVIIPCPILATALQEFLKTIQRAFPVVINDRPVGTGRKELECGE
AVHFDGLHLVGSRVHLGDDDVLMVLVRLSQFIPNGSQLFAVTTPWGIELHKDVFFLIKSHVFKVLPNKHLDRLLVPVLRQLLAHQVGLDF
ALQEAVAELCDPLCRQLLRFGLVLGHLLLQGDEAHGRALFLLQAKELEDALVVGVVAVDEDEQDLALEALGCCFEVAQFAVIVRHTLGQE
QQDVSLDFTSKNLRGCLLGELDDKGQLVVFDKVQQVLLGDLPFKVVPAFIKLLKEDNPIFVELVFGEHVTVGSDPKWYVIDGLCCLQKLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUBP2-P4HB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUBP2-P4HB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUBP2-P4HB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneP4HBC4317154COLE-CARPENTER SYNDROME 12GENOMICS_ENGLAND;UNIPROT
TgeneP4HBC0001787Osteoporosis, Age-Related1CTD_human
TgeneP4HBC0019193Hepatitis, Toxic1CTD_human
TgeneP4HBC0029434Osteogenesis Imperfecta1GENOMICS_ENGLAND
TgeneP4HBC0029456Osteoporosis1CTD_human
TgeneP4HBC0029459Osteoporosis, Senile1CTD_human
TgeneP4HBC0033578Prostatic Neoplasms1CTD_human
TgeneP4HBC0151744Myocardial Ischemia1CTD_human
TgeneP4HBC0376358Malignant neoplasm of prostate1CTD_human
TgeneP4HBC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneP4HBC0860207Drug-Induced Liver Disease1CTD_human
TgeneP4HBC1262760Hepatitis, Drug-Induced1CTD_human
TgeneP4HBC1846707SPINOCEREBELLAR ATAXIA 171CTD_human
TgeneP4HBC1862178Cole Carpenter syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneP4HBC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneP4HBC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneP4HBC4279912Chemically-Induced Liver Toxicity1CTD_human