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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP10-TMEM184C (FusionGDB2 ID:6039)

Fusion Gene Summary for ARHGAP10-TMEM184C

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP10-TMEM184C
Fusion gene ID: 6039
HgeneTgene
Gene symbol

ARHGAP10

TMEM184C

Gene ID

79658

55751

Gene nameRho GTPase activating protein 10transmembrane protein 184C
SynonymsGRAF2|PS-GAP|PSGAPTMEM34
Cytomap

4q31.23

4q31.23

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10transmembrane protein 184Ctransmembrane protein 34
Modification date2020031320200313
UniProtAcc

A1A4S6

.
Ensembl transtripts involved in fusion geneENST00000336498, ENST00000414545, 
ENST00000510076, 		ENST00000296582, 
ENST00000508208, 
Fusion gene scores* DoF score8 X 9 X 7=5043 X 2 X 4=24
# samples 105
** MAII scorelog2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP10 [Title/Abstract] AND TMEM184C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP10(148653606)-TMEM184C(148593018), # samples:1
ARHGAP10(148803083)-TMEM184C(148593018), # samples:1
ARHGAP10(148653606)-TMEM184C(148544985), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP10-TMEM184C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMEM184C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08J-01AARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
ChimerDB4BLCATCGA-FD-A3B8-01AARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
ChimerDB4UCSTCGA-NA-A4R1-01AARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+


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Fusion Gene ORF analysis for ARHGAP10-TMEM184C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336498ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
5CDS-intronENST00000336498ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
intron-intronENST00000414545ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
intron-intronENST00000414545ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
intron-intronENST00000510076ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
intron-intronENST00000510076ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148593018

+
5CDS-intronENST00000336498ENST00000296582ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
5CDS-intronENST00000336498ENST00000508208ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
5UTR-intronENST00000414545ENST00000296582ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
5UTR-intronENST00000414545ENST00000508208ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
intron-intronENST00000510076ENST00000296582ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
intron-intronENST00000510076ENST00000508208ARHGAP10chr4

148803083

-TMEM184Cchr4

148593018

+
Frame-shiftENST00000336498ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+
Frame-shiftENST00000336498ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+
intron-3CDSENST00000414545ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+
intron-3CDSENST00000414545ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+
intron-3CDSENST00000510076ENST00000296582ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+
intron-3CDSENST00000510076ENST00000508208ARHGAP10chr4

148653606

-TMEM184Cchr4

148544985

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGAP10-TMEM184C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP10-TMEM184C


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP10

A1A4S6

.
FUNCTION: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250, ECO:0000269|PubMed:11432776}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGAP10-TMEM184C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGAP10-TMEM184C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP10-TMEM184C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP10-TMEM184C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP10C0004238Atrial Fibrillation2CTD_human
HgeneARHGAP10C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneARHGAP10C2585653Persistent atrial fibrillation2CTD_human
HgeneARHGAP10C3468561familial atrial fibrillation2CTD_human