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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUMA1-CRYM (FusionGDB2 ID:60527)

Fusion Gene Summary for NUMA1-CRYM

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMA1-CRYM
Fusion gene ID: 60527
HgeneTgene
Gene symbol

NUMA1

CRYM

Gene ID

4926

1428

Gene namenuclear mitotic apparatus protein 1crystallin mu
SynonymsNMP-22|NUMADFNA40|THBP
Cytomap

11q13.4

16p12.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear proteinketimine reductase mu-crystallinNADP-regulated thyroid-hormone binding proteinmu-crystallin homologthiomorpholine-carboxylate dehydrogenase
Modification date2020031320200313
UniProtAcc.

Q14894

Ensembl transtripts involved in fusion geneENST00000351960, ENST00000358965, 
ENST00000393695, ENST00000543450, 
ENST00000543948, ENST00000219599, 
ENST00000415987, ENST00000396023, 
ENST00000574787, 
Fusion gene scores* DoF score36 X 22 X 17=134647 X 5 X 5=175
# samples 437
** MAII scorelog2(43/13464*10)=-4.96862661174049
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUMA1 [Title/Abstract] AND CRYM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUMA1(71713910)-CRYM(21290281), # samples:1
Anticipated loss of major functional domain due to fusion event.NUMA1-CRYM seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NUMA1-CRYM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUMA1

GO:0000132

establishment of mitotic spindle orientation

21816348

HgeneNUMA1

GO:0030953

astral microtubule organization

12445386

HgeneNUMA1

GO:0060236

regulation of mitotic spindle organization

26195665

HgeneNUMA1

GO:1902365

positive regulation of protein localization to spindle pole body

16076287


check buttonFusion gene breakpoints across NUMA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CRYM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7821-01ANUMA1chr11

71713910

-CRYMchr16

21290281

-


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Fusion Gene ORF analysis for NUMA1-CRYM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000351960ENST00000543948NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000351960ENST00000219599NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000351960ENST00000415987NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000351960ENST00000396023NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000351960ENST00000574787NUMA1chr11

71713910

-CRYMchr16

21290281

-
Frame-shiftENST00000358965ENST00000543948NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000358965ENST00000219599NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000358965ENST00000415987NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000358965ENST00000396023NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000358965ENST00000574787NUMA1chr11

71713910

-CRYMchr16

21290281

-
In-frameENST00000393695ENST00000543948NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000393695ENST00000219599NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000393695ENST00000415987NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-intronENST00000393695ENST00000396023NUMA1chr11

71713910

-CRYMchr16

21290281

-
5CDS-5UTRENST00000393695ENST00000574787NUMA1chr11

71713910

-CRYMchr16

21290281

-
intron-3CDSENST00000543450ENST00000543948NUMA1chr11

71713910

-CRYMchr16

21290281

-
intron-5UTRENST00000543450ENST00000219599NUMA1chr11

71713910

-CRYMchr16

21290281

-
intron-intronENST00000543450ENST00000415987NUMA1chr11

71713910

-CRYMchr16

21290281

-
intron-intronENST00000543450ENST00000396023NUMA1chr11

71713910

-CRYMchr16

21290281

-
intron-5UTRENST00000543450ENST00000574787NUMA1chr11

71713910

-CRYMchr16

21290281

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351960NUMA1chr1171713910-ENST00000543948CRYMchr1621290281-517537751543111985
ENST00000393695NUMA1chr1171713910-ENST00000543948CRYMchr1621290281-8743734331466792121

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351960ENST00000543948NUMA1chr1171713910-CRYMchr1621290281-0.0031706540.99682933
ENST00000393695ENST00000543948NUMA1chr1171713910-CRYMchr1621290281-0.0232769060.97672313

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Fusion Genomic Features for NUMA1-CRYM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUMA1-CRYM


check button Go to

FGviewer for the breakpoints of chr11:71713910-chr16:21290281

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CRYM

Q14894

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269|PubMed:21332720}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-2727213_16992323.02102.0Coiled coilOntology_term=ECO:0000255
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-2727213_16992337.02116.0Coiled coilOntology_term=ECO:0000255
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271742_17482323.02102.0MotifTankyrase-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271984_19892323.02102.0MotifNuclear localization signal
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271742_17482337.02116.0MotifTankyrase-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271984_19892337.02116.0MotifNuclear localization signal
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271699_18762323.02102.0RegionMembrane-binding domain 1
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271700_21152323.02102.0RegionNote=Tail (Globular)
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271788_18102323.02102.0Region4.1-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271882_19852323.02102.0RegionTubulin-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271892_19262323.02102.0RegionGPSM2-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271981_20602323.02102.0RegionMembrane-binding domain 2
HgeneNUMA1chr11:71713910chr16:21290281ENST00000358965-27271_2122323.02102.0RegionNote=Head (Globular)
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271699_18762337.02116.0RegionMembrane-binding domain 1
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271700_21152337.02116.0RegionNote=Tail (Globular)
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271788_18102337.02116.0Region4.1-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271882_19852337.02116.0RegionTubulin-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271892_19262337.02116.0RegionGPSM2-binding domain
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271981_20602337.02116.0RegionMembrane-binding domain 2
HgeneNUMA1chr11:71713910chr16:21290281ENST00000393695-27271_2122337.02116.0RegionNote=Head (Globular)
TgeneCRYMchr11:71713910chr16:21290281ENST00000219599010143_1480315.0Nucleotide bindingNADP
TgeneCRYMchr11:71713910chr16:21290281ENST0000039602308143_1480315.0Nucleotide bindingNADP
TgeneCRYMchr11:71713910chr16:21290281ENST00000543948-19143_1480315.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NUMA1-CRYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000351960_ENST00000543948_TCGA-HC-7821-01A_NUMA1_chr11_71713910_-_CRYM_chr16_21290281_length(transcript)=5175nt_BP=3775nt
GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC
AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT
CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTG
CAGCATCTTCATCAAGATCATTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTT
TGTGTGCAGTTTTCTGCAGAAAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCT
GGAACTGGCGAAGATGACCATGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAAT
TCAGGCTGAGTTGGCTGTCATTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAA
AGCTCCTGTGCCTTCTACCTGTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGA
GCTACAGAAGGTTGCCTCCTCTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACA
GTTCCAGATGAGACGGCTGAAGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCT
CCTCACCGAGAAGGATGCACAGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACT
GGAGCCCAAGGAGCTTGAGGAGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAA
GACAGAGAAGAGCCAGATGGATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCA
TCTGCAGCAGCTACAGGATGCCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGA
GAAGGAGCTCAGCGCAGCCCTGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACA
CTTGTCCCAGCTGCAGGATAACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGGTGGAAGAACTGAGTAAGAAACTGGC
TGACTCTGACCAAGCCAGCAAGGTGCAGCAGCAGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCT
CCAGGCCCAGCTGAATGAACTGCAAGCCCAGTTGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAAC
ACATTATGATGCCAAGAAGCAGCAGAACCAAGAGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCG
AGCTGAAGCTGAACGGCTGGGCCATGAGCTACAGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCA
GGTGCGCAGCCTGGAGGCACAGGTTGCCCATGCAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAG
CCGTGAGCCCCAGGCTAAGCCCCAGCTGGACTTGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAG
CAAGCTGCCTCGTACCCAGCCAGACGGCACCAGCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATC
CCTGGAGAGTCTCTACTTCACTCCCATCCCTGCTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGA
CTCGGGTCGTAAGACCCGCTCCGCTCGTCGGCGCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGA
CAGCGCCAACTCATCGTTCTACAGCACGCGGTCTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCG
CCTGGGTTCTCCCGATTATGGCAACTCAGCCCTGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGC
CGGGGTGTCCAGTGGGGCCCCTCCAGGAAGGAACAGCTTCTACATGGGCACTTGCCAGGATGAGCCTGAGCAGCTGGATGACTGGAACCG
CATTGCAGAGCTGCAGCAGCGCAATCGAGTGTGCCCCCCACATCTGAAGACCTGCTATCCCCTGGAGTCCAGGCCTTCCCTGAGCCTGGG
CACCATCACAGATGAGGAGATGAAAACTGGAGACCCCCAAGAGACCCTGCGCCGAGCCAGCATGCAGCCAATCCAGATAGCCGAGGGCAC
TGGCATCACCACCCGGCAGCAGCGCAAACGGGTCTCCCTAGAGCCCCACCAGGGCCCTGGAACTCCTGAGTCTAAGAAGGCCACCAGCTG
TTTCCCACGCCCCATGACTCCCCGAGACCGACATGAAGGGCGCAAACAGAGCACTACTGAGGCCCAGAAGAAAGCAGCTCCAGCTTCTAC
TAAACAGGCTGACCGGCGCCAGTCGATGGCCTTCAGCATCCTCAACACACCCAAGAAGCTAGGGAACAGCCTTCTGCGGCGGGGAGCCTC
AAAGAAGGCCCTGTCCAAGGCTTCCCCCAACACTCGCAGTGGAACCCGCCGTTCTCCGCGCATTGCCACCACCACAGCCAGCGCCGCCAC
TGCTGCCGCCATTGGTGCCACCCCTCGAGCCAAGGGCAAGGCAAAGCACTAAAGGGCCAGTACCAGTGAGTGGCCCCACCTGTGTCCCCG
ATGCTGACCTCACCTGGTCCTCCGCCTACTGTCCCTCTCAGTGCCTTCTCTCAGCTCCCAGGCCAACAGTAGCCAAACCCCTAGAGACAG
TGATGCCTGCCCGCACCCTGGCCTGGTCCCTGGTCCTTCACTGGCGCCTTCTCGGAGCTGGCCCAGGGGGCCTGGAGCATGGACAGTGTG
GGCGCTCTCCCTACCTTGCCTCCTTTTTTCTTAAAGCAAAGTCACTTCTCCATCACAACCAGATTTGAGGCTGGTTTTGATGGCTGGGTC
CTTGGGCCTGGCCAGTCTTCCTCTTAGCCTCTGGATCTAGAAGGGACCATAAGAGGAGTAGGCCCTGGTTCCTGCTGTCCTGGTGGCTGG
GCCCAGCAGGGGCCCTCACTCTTGAAGTCCAGGACTGGGTCTGACCTGGTGGGAGCACCTGCCAGAGGATGCTCTTTCCCAGGACGGATG
GGCCCTATGTCTCAGGAGTGGGGTTGGGGGACAGCCTTCAGCAGCAGCTCACACCCTACCTTCCCCAGACTTGCACTGGGGTGGGATTTG
GAGTGATGGGAAGGTTTTTAAGGGCCGGGGATGGATCTTTTCTAAATGTTATTACTTGTAAATAAAGTCTATTTTTCTCCCGTGAGTAAA
AACTCCTGGAAGAAAAGATCCTGCAATTTGGCTTTTTGTGAGATGGAAAAGATTACACCTTGCCCTGCAAACTTCCCCCCTTTAAAGGCG
AAGGTTTGTTAGAGCAGCGGGCGCGCTCATAAAGGGCACAGCCGAGGGTACGTGGATCGCGGTGCGGAGACTGAGGTTAGAAGGCACAGG
TGGCGAGATGAGCCGGGTACCAGCGTTCCTGAGCGCGGCCGAGGTGGAGGAACACCTCCGCAGCTCCAGCCTCCTCATCCCGCCTCTAGA
GACGGCCCTGGCCAACTTCTCCAGCGGTCCCGAAGGAGGGGTCATGCAGCCCGTGCGCACCGTGGTGCCGGTGACCAAGCACAGGGGCTA
CCTGGGGGTCATGCCCGCCTACAGTGCTGCAGAGGATGCACTGACCACCAAGTTGGTCACCTTCTACGAGGACCGCGGCATCACCTCGGT
CGTCCCTTCCCACCAGGCTACTGTGCTACTCTTTGAGCCCAGCAATGGCACCCTGCTGGCGGTCATGGATGGAAATGTCATAACTGCAAA
GAGAACAGCTGCAGTTTCTGCCATTGCCACCAAGTTTCTGAAACCTCCCAGCAGTGAAGTGCTGTGCATCCTTGGGGCTGGGGTCCAGGC
CTACAGCCATTATGAGATCTTCACAGAGCAGTTCTCCTTTAAGGAGGTGAGGATATGGAACCGCACCAAAGAAAATGCAGAGAAGTTTGC
AGACACAGTGCAAGGAGAGGTACGGGTCTGTTCTTCGGTCCAGGAGGCTGTGGCAGGTGCAGATGTGATCATCACAGTCACCCTGGCAAC
AGAGCCCATTTTGTTTGGTGAATGGGTGAAGCCAGGGGCTCACATCAATGCTGTTGGAGCCAGCAGACCTGACTGGAGAGAACTGGATGA
TGAGCTCATGAAAGAAGCTGTGCTGTACGTGGATTCCCAGGAGGCTGCCCTGAAGGAGTCTGGAGATGTCCTGCTGTCAGGGGCCGAGAT
CTTTGCTGAGCTGGGAGAAGTGATTAAGGGAGTGAAACCAGCCCACTGTGAGAAGACCACCGTGTTCAAGTCTTTGGGAATGGCAGTGGA
AGACACAGTTGCAGCCAAACTCATCTATGATTCCTGGTCATCTGGTAAATAAAACAAAGGAACTTGATGTTGAGATGGATGCTTGAGGAA
TATTGCTGCTGGTTCTCATAATTTCTAGAGTAAATGAGGGAGTCCAGTCCCCAGTGAACTCTCCTTTTGTGCTTATCATGTTTTACCTTA
AATGCTGAGATCCTCATTTATGTTTGTAGTTGGAAAGCAAAGCTAGGTAGCCATTTCTTCTGTTCTACCAAGTTATAATAGCATTCATTT

>In-frame_ENST00000351960_ENST00000543948_TCGA-HC-7821-01A_NUMA1_chr11_71713910_-_CRYM_chr16_21290281_length(amino acids)=985AA_start in transcript=154_stop in transcript=3111
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQVEELSKKLADSDQASKVQQQKLKAVQAQGG
ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE
QTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS
QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRA
TSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPL
ESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEA

--------------------------------------------------------------
>In-frame_ENST00000393695_ENST00000543948_TCGA-HC-7821-01A_NUMA1_chr11_71713910_-_CRYM_chr16_21290281_length(transcript)=8743nt_BP=7343nt
AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC
GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA
AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT
GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG
CACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTGCAGCATCTTCATCAAGATCA
TTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTTTGTGTGCAGTTTTCTGCAGA
AAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCTGGAACTGGCGAAGATGACCA
TGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAATTCAGGCTGAGTTGGCTGTCA
TTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAAAGCTCCTGTGCCTTCTACCT
GTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGAGCTACAGAAGGTTGCCTCCT
CTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACAGTTCCAGATGAGACGGCTGA
AGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCTCCTCACCGAGAAGGATGCAC
AGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACTGGAGCCCAAGGAGCTTGAGG
AGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAAGACAGAGAAGAGCCAGATGG
ATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCATCTGCAGCAGCTACAGGATG
CCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGAGAAGGAGCTCAGCGCAGCCC
TGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACACTTGTCCCAGCTGCAGGATA
ACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGCTGGAAACCTTGAAGCAAGAGGCAGCCACTCTTGCTGCAAACAACA
CACAGCTCCAAGCCAGGGTAGAGATGCTGGAGACTGAGCGAGGCCAGCAGGAAGCCAAGCTGCTTGCTGAGCGGGGCCACTTCGAAGAAG
AAAAGCAGCAGCTGTCTAGCCTGATCACTGACCTGCAGAGCTCCATCTCCAACCTCAGCCAGGCCAAGGAAGAGCTGGAGCAGGCCTCCC
AGGCTCATGGGGCCCGGTTGACTGCCCAGGTGGCCTCTCTGACCTCTGAGCTCACCACACTCAATGCCACCATCCAGCAACAGGATCAAG
AACTGGCTGGCCTGAAGCAGCAGGCCAAAGAGAAGCAGGCCCAGCTAGCACAGACCCTCCAACAGCAAGAACAGGCCTCCCAGGGCCTCC
GCCACCAGGTGGAGCAGCTAAGCAGTAGCCTGAAGCAGAAGGAGCAGCAGTTGAAGGAGGTAGCGGAGAAGCAGGAGGCAACTAGGCAGG
ACCATGCCCAGCAACTGGCCACTGCTGCAGAGGAGCGAGAGGCCTCCTTAAGGGAGCGGGATGCGGCTCTCAAGCAGCTGGAGGCACTGG
AGAAGGAGAAGGCTGCCAAGCTGGAGATTCTGCAGCAGCAACTTCAGGTGGCTAATGAAGCCCGGGACAGTGCCCAGACCTCAGTGACAC
AGGCCCAGCGGGAGAAGGCAGAGCTGAGCCGGAAGGTGGAGGAACTCCAGGCCTGTGTTGAGACAGCCCGCCAGGAACAGCATGAGGCCC
AGGCCCAGGTTGCAGAGCTAGAGTTGCAGCTGCGGTCTGAGCAGCAAAAAGCAACTGAGAAAGAAAGGGTGGCCCAGGAGAAGGACCAGC
TCCAGGAGCAGCTCCAGGCCCTCAAAGAGTCCTTGAAGGTCACCAAGGGCAGCCTTGAAGAGGAGAAGCGCAGGGCTGCAGATGCCCTGG
AAGAGCAGCAGCGTTGTATCTCTGAGCTGAAGGCAGAGACCCGAAGCCTGGTGGAGCAGCATAAGCGGGAACGAAAGGAGCTGGAAGAAG
AGAGGGCTGGGCGCAAGGGGCTGGAGGCTCGATTACAGCAGCTTGGGGAGGCCCATCAGGCTGAGACTGAAGTCCTGCGGCGGGAGCTGG
CAGAGGCCATGGCTGCCCAGCACACAGCTGAGAGTGAGTGTGAGCAGCTCGTCAAAGAAGTAGCTGCCTGGCGTGAGCGGTATGAGGATA
GCCAGCAAGAGGAGGCACAGTATGGCGCCATGTTCCAGGAACAGCTGATGACTTTGAAGGAGGAATGTGAGAAGGCCCGCCAGGAGCTGC
AGGAGGCAAAGGAGAAGGTGGCAGGCATAGAATCCCACAGCGAGCTCCAGATAAGCCGGCAGCAGAACGAACTAGCTGAGCTCCATGCCA
ACCTGGCCAGAGCACTCCAGCAGGTCCAAGAGAAGGAAGTCAGGGCCCAGAAGCTTGCAGATGACCTCTCCACTCTGCAGGAAAAGATGG
CTGCCACCAGCAAAGAGGTGGCCCGCTTGGAGACCTTGGTGCGCAAGGCAGGTGAGCAGCAGGAAACAGCCTCCCGGGAGTTAGTCAAGG
AGCCTGCGAGGGCAGGAGACAGACAGCCCGAGTGGCTGGAAGAGCAACAGGGACGCCAGTTCTGCAGCACACAGGCAGCGCTGCAGGCTA
TGGAGCGGGAGGCAGAGCAGATGGGCAATGAGCTGGAACGGCTGCGGGCCGCGCTGATGGAGAGCCAGGGGCAGCAGCAGGAGGAGCGTG
GGCAGCAGGAAAGGGAGGTGGCGCGGCTGACCCAGGAGCGGGGCCGTGCCCAGGCTGACCTTGCCCTGGAGAAGGCGGCCAGAGCAGAGC
TTGAGATGCGGCTGCAGAACGCCCTCAACGAGCAGCGTGTGGAGTTCGCTACCCTGCAAGAGGCACTGGCTCATGCCCTGACGGAAAAGG
AAGGCAAGGACCAGGAGTTGGCCAAGCTTCGTGGTCTGGAGGCAGCCCAGATAAAAGAGCTGGAGGAACTTCGGCAAACCGTGAAGCAAC
TGAAGGAACAGCTGGCTAAGAAAGAAAAGGAGCACGCATCTGGCTCAGGAGCCCAATCTGAGGCTGCTGGCAGGACAGAGCCAACAGGCC
CCAAGCTGGAGGCACTGCGGGCAGAGGTGAGCAAGCTGGAACAGCAATGCCAGAAGCAGCAGGAGCAGGCTGACAGCCTGGAACGCAGCC
TCGAGGCTGAGCGGGCCTCCCGGGCTGAGCGGGACAGTGCTCTGGAGACTCTGCAGGGCCAGTTAGAGGAGAAGGCCCAGGAGCTAGGGC
ACAGTCAGAGTGCCTTAGCCTCGGCCCAACGGGAGTTGGCTGCCTTCCGCACCAAGGTACAAGACCACAGCAAGGCTGAAGATGAGTGGA
AGGCCCAGGTGGCCCGGGGCCGGCAAGAGGCTGAGAGGAAAAATAGCCTCATCAGCAGCTTGGAGGAGGAGGTGTCCATCCTGAATCGCC
AGGTCCTGGAGAAGGAGGGGGAGAGCAAGGAGTTGAAGCGGCTGGTGATGGCCGAGTCAGAGAAGAGCCAGAAGCTGGAGGAGAGGCTGC
GCCTGCTGCAGGCAGAGACAGCCAGCAACAGTGCCAGAGCTGCAGAACGCAGCTCTGCTCTGCGGGAGGAGGTGCAGAGCCTCCGGGAGG
AGGCTGAGAAACAGCGGGTGGCTTCAGAGAACCTGCGGCAGGAGCTGACCTCACAGGCTGAGCGTGCGGAGGAGCTGGGCCAAGAATTGA
AGGCGTGGCAGGAGAAGTTCTTCCAGAAAGAGCAGGCCCTCTCCACCCTGCAGCTCGAGCACACCAGCACACAGGCCCTGGTGAGTGAGC
TGCTGCCAGCTAAGCACCTCTGCCAGCAGCTGCAGGCCGAGCAGGCCGCTGCCGAGAAACGCCACCGTGAGGAGCTGGAGCAGAGCAAGC
AGGCCGCTGGGGGACTGCGGGCAGAGCTGCTGCGGGCCCAGCGGGAGCTTGGGGAGCTGATTCCTCTGCGGCAGAAGGTGGCAGAGCAGG
AGCGAACAGCTCAGCAGCTGCGGGCAGAGAAGGCCAGCTATGCAGAGCAGCTGAGCATGCTGAAGAAGGCGCATGGCCTGCTGGCAGAGG
AGAACCGGGGGCTGGGTGAGCGGGCCAACCTTGGCCGGCAGTTTCTGGAAGTGGAGTTGGACCAGGCCCGGGAGAAGTATGTCCAAGAGT
TGGCAGCCGTACGTGCTGATGCTGAGACCCGTCTGGCTGAGGTGCAGCGAGAAGCACAGAGCACTGCCCGGGAGCTGGAGGTGATGACTG
CCAAGTATGAGGGTGCCAAGGTCAAGGTCCTGGAGGAGAGGCAGCGGTTCCAGGAAGAGAGGCAGAAACTCACTGCCCAGGTGGAGCAGC
TAGAGGTATTTCAGAGAGAGCAAACTAAGCAGGTGGAAGAACTGAGTAAGAAACTGGCTGACTCTGACCAAGCCAGCAAGGTGCAGCAGC
AGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCTCCAGGCCCAGCTGAATGAACTGCAAGCCCAGT
TGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAACACATTATGATGCCAAGAAGCAGCAGAACCAAG
AGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCGAGCTGAAGCTGAACGGCTGGGCCATGAGCTAC
AGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCAGGTGCGCAGCCTGGAGGCACAGGTTGCCCATG
CAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAGCCGTGAGCCCCAGGCTAAGCCCCAGCTGGACT
TGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAGCAAGCTGCCTCGTACCCAGCCAGACGGCACCA
GCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATCCCTGGAGAGTCTCTACTTCACTCCCATCCCTG
CTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGACTCGGGTCGTAAGACCCGCTCCGCTCGTCGGC
GCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGACAGCGCCAACTCATCGTTCTACAGCACGCGGT
CTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCGCCTGGGTTCTCCCGATTATGGCAACTCAGCCC
TGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGCCGGGGTGTCCAGTGGGGCCCCTCCAGGAAGGA
ACAGCTTCTACATGGGCACTTGCCAGGATGAGCCTGAGCAGCTGGATGACTGGAACCGCATTGCAGAGCTGCAGCAGCGCAATCGAGTGT
GCCCCCCACATCTGAAGACCTGCTATCCCCTGGAGTCCAGGCCTTCCCTGAGCCTGGGCACCATCACAGATGAGGAGATGAAAACTGGAG
ACCCCCAAGAGACCCTGCGCCGAGCCAGCATGCAGCCAATCCAGATAGCCGAGGGCACTGGCATCACCACCCGGCAGCAGCGCAAACGGG
TCTCCCTAGAGCCCCACCAGGGCCCTGGAACTCCTGAGTCTAAGAAGGCCACCAGCTGTTTCCCACGCCCCATGACTCCCCGAGACCGAC
ATGAAGGGCGCAAACAGAGCACTACTGAGGCCCAGAAGAAAGCAGCTCCAGCTTCTACTAAACAGGCTGACCGGCGCCAGTCGATGGCCT
TCAGCATCCTCAACACACCCAAGAAGCTAGGGAACAGCCTTCTGCGGCGGGGAGCCTCAAAGAAGGCCCTGTCCAAGGCTTCCCCCAACA
CTCGCAGTGGAACCCGCCGTTCTCCGCGCATTGCCACCACCACAGCCAGCGCCGCCACTGCTGCCGCCATTGGTGCCACCCCTCGAGCCA
AGGGCAAGGCAAAGCACTAAAGGGCCAGTACCAGTGAGTGGCCCCACCTGTGTCCCCGATGCTGACCTCACCTGGTCCTCCGCCTACTGT
CCCTCTCAGTGCCTTCTCTCAGCTCCCAGGCCAACAGTAGCCAAACCCCTAGAGACAGTGATGCCTGCCCGCACCCTGGCCTGGTCCCTG
GTCCTTCACTGGCGCCTTCTCGGAGCTGGCCCAGGGGGCCTGGAGCATGGACAGTGTGGGCGCTCTCCCTACCTTGCCTCCTTTTTTCTT
AAAGCAAAGTCACTTCTCCATCACAACCAGATTTGAGGCTGGTTTTGATGGCTGGGTCCTTGGGCCTGGCCAGTCTTCCTCTTAGCCTCT
GGATCTAGAAGGGACCATAAGAGGAGTAGGCCCTGGTTCCTGCTGTCCTGGTGGCTGGGCCCAGCAGGGGCCCTCACTCTTGAAGTCCAG
GACTGGGTCTGACCTGGTGGGAGCACCTGCCAGAGGATGCTCTTTCCCAGGACGGATGGGCCCTATGTCTCAGGAGTGGGGTTGGGGGAC
AGCCTTCAGCAGCAGCTCACACCCTACCTTCCCCAGACTTGCACTGGGGTGGGATTTGGAGTGATGGGAAGGTTTTTAAGGGCCGGGGAT
GGATCTTTTCTAAATGTTATTACTTGTAAATAAAGTCTATTTTTCTCCCGTGAGTAAAAACTCCTGGAAGAAAAGATCCTGCAATTTGGC
TTTTTGTGAGATGGAAAAGATTACACCTTGCCCTGCAAACTTCCCCCCTTTAAAGGCGAAGGTTTGTTAGAGCAGCGGGCGCGCTCATAA
AGGGCACAGCCGAGGGTACGTGGATCGCGGTGCGGAGACTGAGGTTAGAAGGCACAGGTGGCGAGATGAGCCGGGTACCAGCGTTCCTGA
GCGCGGCCGAGGTGGAGGAACACCTCCGCAGCTCCAGCCTCCTCATCCCGCCTCTAGAGACGGCCCTGGCCAACTTCTCCAGCGGTCCCG
AAGGAGGGGTCATGCAGCCCGTGCGCACCGTGGTGCCGGTGACCAAGCACAGGGGCTACCTGGGGGTCATGCCCGCCTACAGTGCTGCAG
AGGATGCACTGACCACCAAGTTGGTCACCTTCTACGAGGACCGCGGCATCACCTCGGTCGTCCCTTCCCACCAGGCTACTGTGCTACTCT
TTGAGCCCAGCAATGGCACCCTGCTGGCGGTCATGGATGGAAATGTCATAACTGCAAAGAGAACAGCTGCAGTTTCTGCCATTGCCACCA
AGTTTCTGAAACCTCCCAGCAGTGAAGTGCTGTGCATCCTTGGGGCTGGGGTCCAGGCCTACAGCCATTATGAGATCTTCACAGAGCAGT
TCTCCTTTAAGGAGGTGAGGATATGGAACCGCACCAAAGAAAATGCAGAGAAGTTTGCAGACACAGTGCAAGGAGAGGTACGGGTCTGTT
CTTCGGTCCAGGAGGCTGTGGCAGGTGCAGATGTGATCATCACAGTCACCCTGGCAACAGAGCCCATTTTGTTTGGTGAATGGGTGAAGC
CAGGGGCTCACATCAATGCTGTTGGAGCCAGCAGACCTGACTGGAGAGAACTGGATGATGAGCTCATGAAAGAAGCTGTGCTGTACGTGG
ATTCCCAGGAGGCTGCCCTGAAGGAGTCTGGAGATGTCCTGCTGTCAGGGGCCGAGATCTTTGCTGAGCTGGGAGAAGTGATTAAGGGAG
TGAAACCAGCCCACTGTGAGAAGACCACCGTGTTCAAGTCTTTGGGAATGGCAGTGGAAGACACAGTTGCAGCCAAACTCATCTATGATT
CCTGGTCATCTGGTAAATAAAACAAAGGAACTTGATGTTGAGATGGATGCTTGAGGAATATTGCTGCTGGTTCTCATAATTTCTAGAGTA
AATGAGGGAGTCCAGTCCCCAGTGAACTCTCCTTTTGTGCTTATCATGTTTTACCTTAAATGCTGAGATCCTCATTTATGTTTGTAGTTG
GAAAGCAAAGCTAGGTAGCCATTTCTTCTGTTCTACCAAGTTATAATAGCATTCATTTCCCTTTATATTTCCCTGAAATAAAGCACATTC

>In-frame_ENST00000393695_ENST00000543948_TCGA-HC-7821-01A_NUMA1_chr11_71713910_-_CRYM_chr16_21290281_length(amino acids)=2121AA_start in transcript=314_stop in transcript=6679
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG
QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ
LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT
KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE
QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR
AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL
RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA
AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL
ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL
VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS
TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYA
EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ
RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM
EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT
DALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLG
DVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSA
RRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQ
IAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLL

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Fusion Gene PPI Analysis for NUMA1-CRYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUMA1-CRYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUMA1-CRYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUMA1C0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
HgeneNUMA1C0162820Dermatitis, Allergic Contact1CTD_human
TgeneCRYMC4084708DEAFNESS, AUTOSOMAL DOMINANT 407CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCRYMC1384666hearing impairment1GENOMICS_ENGLAND