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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:NUMB-TTLL5 (FusionGDB2 ID:60576) |
Fusion Gene Summary for NUMB-TTLL5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NUMB-TTLL5 | Fusion gene ID: 60576 | Hgene | Tgene | Gene symbol | NUMB | TTLL5 | Gene ID | 8650 | 254173 |
Gene name | NUMB endocytic adaptor protein | tubulin tyrosine ligase like 10 | |
Synonyms | C14orf41|S171|c14_5527 | TTLL5 | |
Cytomap | 14q24.2-q24.3 | 1p36.33 | |
Type of gene | protein-coding | protein-coding | |
Description | protein numb homologh-Numbnumb homolog | inactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000554546, ENST00000356296, ENST00000557597, ENST00000555238, ENST00000355058, ENST00000359560, ENST00000555394, ENST00000454166, ENST00000544991, ENST00000560335, ENST00000555738, ENST00000559312, ENST00000554521, ENST00000535282, ENST00000556600, ENST00000556772, | ENST00000557636, ENST00000286650, ENST00000298832, ENST00000556893, ENST00000554510, ENST00000556977, ENST00000555422, | |
Fusion gene scores | * DoF score | 24 X 15 X 9=3240 | 19 X 18 X 11=3762 |
# samples | 26 | 24 | |
** MAII score | log2(26/3240*10)=-3.63941028474353 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(24/3762*10)=-3.97039353791468 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NUMB [Title/Abstract] AND TTLL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NUMB(73759442)-TTLL5(76286350), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | NUMB-TTLL5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TTLL5 | GO:0018094 | protein polyglycylation | 19524510 |
Fusion gene breakpoints across NUMB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TTLL5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-YF-AA3L-01A | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
ChimerDB4 | BLCA | TCGA-YF-AA3L-01A | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
ChimerDB4 | BLCA | TCGA-YF-AA3L-01A | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Top |
Fusion Gene ORF analysis for NUMB-TTLL5 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000554546 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554546 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Frame-shift | ENST00000356296 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000356296 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000557597 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000557597 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000555238 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555238 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Frame-shift | ENST00000355058 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000355058 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Frame-shift | ENST00000359560 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000359560 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000555394 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555394 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000454166 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000454166 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000544991 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000544991 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000560335 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000560335 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000555738 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000555738 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000559312 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000559312 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
In-frame | ENST00000554521 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000554521 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Frame-shift | ENST00000535282 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000535282 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-3CDS | ENST00000556600 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
intron-intron | ENST00000556600 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
Frame-shift | ENST00000556772 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000286650 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000298832 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000556893 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000554510 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000556977 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
5CDS-intron | ENST00000556772 | ENST00000555422 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000554546 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1511 | 774 | 273 | 1403 | 376 |
ENST00000557597 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1416 | 679 | 178 | 1308 | 376 |
ENST00000555238 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1457 | 720 | 186 | 1349 | 387 |
ENST00000555394 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1507 | 770 | 236 | 1399 | 387 |
ENST00000454166 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1205 | 468 | 18 | 1097 | 359 |
ENST00000544991 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1205 | 468 | 18 | 1097 | 359 |
ENST00000560335 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1226 | 489 | 39 | 1118 | 359 |
ENST00000555738 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1193 | 456 | 39 | 1085 | 348 |
ENST00000559312 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1226 | 489 | 39 | 1118 | 359 |
ENST00000554521 | NUMB | chr14 | 73759442 | - | ENST00000557636 | TTLL5 | chr14 | 76286350 | + | 1193 | 456 | 39 | 1085 | 348 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000554546 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.045907676 | 0.9540923 |
ENST00000557597 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.050200246 | 0.9497998 |
ENST00000555238 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.030474694 | 0.9695253 |
ENST00000555394 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.026342997 | 0.973657 |
ENST00000454166 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.04034542 | 0.9596545 |
ENST00000544991 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.04034542 | 0.9596545 |
ENST00000560335 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.043299876 | 0.95670015 |
ENST00000555738 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.07183922 | 0.92816085 |
ENST00000559312 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.043299876 | 0.95670015 |
ENST00000554521 | ENST00000557636 | NUMB | chr14 | 73759442 | - | TTLL5 | chr14 | 76286350 | + | 0.07183922 | 0.92816085 |
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Fusion Genomic Features for NUMB-TTLL5 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
NUMB | chr14 | 73759441 | - | TTLL5 | chr14 | 76286349 | + | 4.26E-07 | 0.9999995 |
NUMB | chr14 | 73759441 | - | TTLL5 | chr14 | 76286349 | + | 4.26E-07 | 0.9999995 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NUMB-TTLL5 |
Go to FGviewer for the breakpoints of chr14:73759442-chr14:76286350 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 552_557 | 0 | 270.0 | Compositional bias | Note=Poly-Arg | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 582_590 | 0 | 270.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 776_780 | 0 | 270.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 827_830 | 0 | 270.0 | Compositional bias | Note=Poly-Asn | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 776_780 | 608.0 | 818.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 827_830 | 608.0 | 818.0 | Compositional bias | Note=Poly-Asn | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 62_407 | 0 | 270.0 | Domain | TTL | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 208_211 | 0 | 270.0 | Nucleotide binding | ATP binding | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000286650 | 0 | 10 | 378_488 | 0 | 270.0 | Region | c-MTBD region |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000355058 | - | 8 | 13 | 33_193 | 150.0 | 652.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000356296 | - | 8 | 12 | 33_193 | 150.0 | 604.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000359560 | - | 7 | 12 | 33_193 | 139.0 | 641.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000454166 | - | 5 | 8 | 33_193 | 150.0 | 506.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000535282 | - | 6 | 11 | 33_193 | 139.0 | 641.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000554546 | - | 7 | 11 | 33_193 | 139.0 | 593.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000555238 | - | 8 | 13 | 33_193 | 150.0 | 652.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000555394 | - | 8 | 12 | 33_193 | 150.0 | 604.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000555738 | - | 5 | 8 | 33_193 | 139.0 | 495.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000557597 | - | 7 | 12 | 33_193 | 139.0 | 641.0 | Domain | PID |
Hgene | NUMB | chr14:73759442 | chr14:76286350 | ENST00000560335 | - | 6 | 9 | 33_193 | 150.0 | 506.0 | Domain | PID |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 552_557 | 1057.0 | 1282.0 | Compositional bias | Note=Poly-Arg | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 582_590 | 1057.0 | 1282.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 776_780 | 1057.0 | 1282.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 827_830 | 1057.0 | 1282.0 | Compositional bias | Note=Poly-Asn | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 552_557 | 608.0 | 818.0 | Compositional bias | Note=Poly-Arg | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 582_590 | 608.0 | 818.0 | Compositional bias | Note=Poly-Glu | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 62_407 | 1057.0 | 1282.0 | Domain | TTL | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 62_407 | 608.0 | 818.0 | Domain | TTL | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 208_211 | 1057.0 | 1282.0 | Nucleotide binding | ATP binding | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 208_211 | 608.0 | 818.0 | Nucleotide binding | ATP binding | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000298832 | 26 | 32 | 378_488 | 1057.0 | 1282.0 | Region | c-MTBD region | |
Tgene | TTLL5 | chr14:73759442 | chr14:76286350 | ENST00000556893 | 12 | 17 | 378_488 | 608.0 | 818.0 | Region | c-MTBD region |
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Fusion Gene Sequence for NUMB-TTLL5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000554546_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1511nt_BP=774nt CAATGGATAGGTTAGAAGTATGAAAGAGGGTGGGCCTGTTGTCATGGGGGAGGTGGTGGCGCTTGGTGGCCACTGGCGGCCGAGGTAGAG GCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTAC AATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGA GGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATG AACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGC GTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCT GTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACT AAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGT GATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAAC AGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCC GAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAG GCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAA CTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACA ATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCA AGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGC TTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATC >In-frame_ENST00000554546_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=376AA_start in transcript=273_stop in transcript=1403 MVKLRNLSKITQLVKGTAKIQSQAVKIKMNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAV KRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINR SSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKL QSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRF -------------------------------------------------------------- >In-frame_ENST00000557597_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1416nt_BP=679nt GGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTACAATTC AAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGAGGCTT GGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAA ATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCG CACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAA AAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGA CCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGG CACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAG CAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAA TCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTAC AGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCA GTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAA TAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTC TTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAG ATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAAC >In-frame_ENST00000557597_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=376AA_start in transcript=178_stop in transcript=1308 MVKLRNLSKITQLVKGTAKIQSQAVKIKMNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAV KRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINR SSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKL QSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRF -------------------------------------------------------------- >In-frame_ENST00000555238_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1457nt_BP=720nt GAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGT TACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAAC TGAGGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAA ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA ACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTCTCCAGG >In-frame_ENST00000555238_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=387AA_start in transcript=186_stop in transcript=1349 MVKLRNLSKITQLVKGTAKIQSQAVKIKMNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAV KRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVT NLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQ FALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRR -------------------------------------------------------------- >In-frame_ENST00000555394_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1507nt_BP=770nt GTTGTCATGGGGGAGGTGGTGGCGCTTGGTGGCCACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGAT TTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATA TTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGAGGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACAC AACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATG TTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACC TTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAG GCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGG ACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATG GCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAA GCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGA ATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTA CAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTC AGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGA ATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTT CTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCA GATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAA >In-frame_ENST00000555394_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=387AA_start in transcript=236_stop in transcript=1399 MVKLRNLSKITQLVKGTAKIQSQAVKIKMNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAV KRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVT NLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQ FALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRR -------------------------------------------------------------- >In-frame_ENST00000454166_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1205nt_BP=468nt CAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAG TGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGA ATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTT AAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTT TCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTC ATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCC ATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTG CAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCC ACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCC CGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCC ACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCC AACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTC TTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCC >In-frame_ENST00000454166_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=359AA_start in transcript=18_stop in transcript=1097 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF -------------------------------------------------------------- >In-frame_ENST00000544991_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1205nt_BP=468nt CAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAG TGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGA ATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTT AAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTT TCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTC ATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCC ATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTG CAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCC ACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCC CGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCC ACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCC AACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTC TTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCC >In-frame_ENST00000544991_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=359AA_start in transcript=18_stop in transcript=1097 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF -------------------------------------------------------------- >In-frame_ENST00000560335_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1226nt_BP=489nt GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGA AAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTT GACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGT CGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCA GCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGC TCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTC CCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAG CTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCA GGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCC CTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTT CAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGT >In-frame_ENST00000560335_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=359AA_start in transcript=39_stop in transcript=1118 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF -------------------------------------------------------------- >In-frame_ENST00000555738_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1193nt_BP=456nt GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTG TGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCC CCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAG GACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCT AGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGA TTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGC TATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCA ATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGC CAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAA GTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTC AGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTC >In-frame_ENST00000555738_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=348AA_start in transcript=39_stop in transcript=1085 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW -------------------------------------------------------------- >In-frame_ENST00000559312_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1226nt_BP=489nt GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGA AAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTT GACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGT CGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCA GCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGC TCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTC CCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAG CTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCA GGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCC CTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTT CAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGT >In-frame_ENST00000559312_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=359AA_start in transcript=39_stop in transcript=1118 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF -------------------------------------------------------------- >In-frame_ENST00000554521_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(transcript)=1193nt_BP=456nt GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTG TGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCC CCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAG GACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCT AGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGA TTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGC TATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCA ATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGC CAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAA GTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTC AGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTC >In-frame_ENST00000554521_ENST00000557636_TCGA-YF-AA3L-01A_NUMB_chr14_73759442_-_TTLL5_chr14_76286350_length(amino acids)=348AA_start in transcript=39_stop in transcript=1085 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NUMB-TTLL5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NUMB-TTLL5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NUMB-TTLL5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NUMB | C4085590 | Cone-Rod Dystrophies | 1 | GENOMICS_ENGLAND |
Tgene | TTLL5 | C4014501 | CONE-ROD DYSTROPHY 19 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | TTLL5 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
Tgene | TTLL5 | C3489532 | Cone-Rod Dystrophy 2 | 1 | ORPHANET |
Tgene | TTLL5 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | TTLL5 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
Tgene | TTLL5 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
Tgene | TTLL5 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |