FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NUP133-PARPBP (FusionGDB2 ID:60593)

Fusion Gene Summary for NUP133-PARPBP

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP133-PARPBP
Fusion gene ID: 60593
HgeneTgene
Gene symbol

NUP133

PARPBP

Gene ID

55746

55010

Gene namenucleoporin 133PARP1 binding protein
SynonymsGAMOS8|NPHS18|hNUP133AROM|C12orf48|PARI
Cytomap

1q42.13

12q23.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup133133 kDa nucleoporinnucleoporin 133kDnucleoporin 133kDanucleoporin Nup133PCNA-interacting partner
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261396, ENST00000537506, 
ENST00000366678, ENST00000485119, 
ENST00000327680, ENST00000378128, 
ENST00000541394, ENST00000543784, 
ENST00000537257, ENST00000358383, 
ENST00000392911, ENST00000535811, 
Fusion gene scores* DoF score7 X 8 X 6=3363 X 3 X 3=27
# samples 85
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP133 [Title/Abstract] AND PARPBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP133(229633883)-PARPBP(102589729), # samples:2
Anticipated loss of major functional domain due to fusion event.NUP133-PARPBP seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NUP133-PARPBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP133

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across NUP133 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PARPBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1691-01ANUP133chr1

229633883

-PARPBPchr12

102589729

+
ChimerDB4OVTCGA-29-1691NUP133chr1

229633882

-PARPBPchr12

102589728

+
ChimerDB4OVTCGA-29-1691-01ANUP133chr1

229633883

-PARPBPchr12

102589729

+


Top

Fusion Gene ORF analysis for NUP133-PARPBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261396ENST00000327680NUP133chr1

229633883

-PARPBPchr12

102589729

+
In-frameENST00000261396ENST00000378128NUP133chr1

229633883

-PARPBPchr12

102589729

+
Frame-shiftENST00000261396ENST00000541394NUP133chr1

229633883

-PARPBPchr12

102589729

+
In-frameENST00000261396ENST00000543784NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000261396ENST00000537257NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000261396ENST00000358383NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000261396ENST00000392911NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-3UTRENST00000261396ENST00000535811NUP133chr1

229633883

-PARPBPchr12

102589729

+
Frame-shiftENST00000537506ENST00000327680NUP133chr1

229633883

-PARPBPchr12

102589729

+
In-frameENST00000537506ENST00000378128NUP133chr1

229633883

-PARPBPchr12

102589729

+
Frame-shiftENST00000537506ENST00000541394NUP133chr1

229633883

-PARPBPchr12

102589729

+
In-frameENST00000537506ENST00000543784NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000537506ENST00000537257NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000537506ENST00000358383NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-intronENST00000537506ENST00000392911NUP133chr1

229633883

-PARPBPchr12

102589729

+
5CDS-3UTRENST00000537506ENST00000535811NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000366678ENST00000327680NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000366678ENST00000378128NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000366678ENST00000541394NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000366678ENST00000543784NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000366678ENST00000537257NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000366678ENST00000358383NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000366678ENST00000392911NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3UTRENST00000366678ENST00000535811NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000485119ENST00000327680NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000485119ENST00000378128NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000485119ENST00000541394NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3CDSENST00000485119ENST00000543784NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000485119ENST00000537257NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000485119ENST00000358383NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-intronENST00000485119ENST00000392911NUP133chr1

229633883

-PARPBPchr12

102589729

+
intron-3UTRENST00000485119ENST00000535811NUP133chr1

229633883

-PARPBPchr12

102589729

+
Frame-shiftENST00000261396ENST00000327680NUP133chr1

229633882

-PARPBPchr12

102589728

+
In-frameENST00000261396ENST00000378128NUP133chr1

229633882

-PARPBPchr12

102589728

+
Frame-shiftENST00000261396ENST00000541394NUP133chr1

229633882

-PARPBPchr12

102589728

+
In-frameENST00000261396ENST00000543784NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000261396ENST00000537257NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000261396ENST00000358383NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000261396ENST00000392911NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-3UTRENST00000261396ENST00000535811NUP133chr1

229633882

-PARPBPchr12

102589728

+
Frame-shiftENST00000537506ENST00000327680NUP133chr1

229633882

-PARPBPchr12

102589728

+
In-frameENST00000537506ENST00000378128NUP133chr1

229633882

-PARPBPchr12

102589728

+
Frame-shiftENST00000537506ENST00000541394NUP133chr1

229633882

-PARPBPchr12

102589728

+
In-frameENST00000537506ENST00000543784NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000537506ENST00000537257NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000537506ENST00000358383NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-intronENST00000537506ENST00000392911NUP133chr1

229633882

-PARPBPchr12

102589728

+
5CDS-3UTRENST00000537506ENST00000535811NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000366678ENST00000327680NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000366678ENST00000378128NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000366678ENST00000541394NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000366678ENST00000543784NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000366678ENST00000537257NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000366678ENST00000358383NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000366678ENST00000392911NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3UTRENST00000366678ENST00000535811NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000485119ENST00000327680NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000485119ENST00000378128NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000485119ENST00000541394NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3CDSENST00000485119ENST00000543784NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000485119ENST00000537257NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000485119ENST00000358383NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-intronENST00000485119ENST00000392911NUP133chr1

229633882

-PARPBPchr12

102589728

+
intron-3UTRENST00000485119ENST00000535811NUP133chr1

229633882

-PARPBPchr12

102589728

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261396NUP133chr1229633883-ENST00000378128PARPBPchr12102589729+248191177919280
ENST00000261396NUP133chr1229633883-ENST00000543784PARPBPchr12102589729+132991177919280
ENST00000537506NUP133chr1229633883-ENST00000378128PARPBPchr12102589729+244887892886264
ENST00000537506NUP133chr1229633883-ENST00000543784PARPBPchr12102589729+129687892886264
ENST00000261396NUP133chr1229633882-ENST00000378128PARPBPchr12102589728+248191177919280
ENST00000261396NUP133chr1229633882-ENST00000543784PARPBPchr12102589728+132991177919280
ENST00000537506NUP133chr1229633882-ENST00000378128PARPBPchr12102589728+244887892886264
ENST00000537506NUP133chr1229633882-ENST00000543784PARPBPchr12102589728+129687892886264

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261396ENST00000378128NUP133chr1229633883-PARPBPchr12102589729+0.0411475080.95885247
ENST00000261396ENST00000543784NUP133chr1229633883-PARPBPchr12102589729+0.086876880.9131231
ENST00000537506ENST00000378128NUP133chr1229633883-PARPBPchr12102589729+0.0084685350.99153143
ENST00000537506ENST00000543784NUP133chr1229633883-PARPBPchr12102589729+0.0249077360.9750923
ENST00000261396ENST00000378128NUP133chr1229633882-PARPBPchr12102589728+0.0411475080.95885247
ENST00000261396ENST00000543784NUP133chr1229633882-PARPBPchr12102589728+0.086876880.9131231
ENST00000537506ENST00000378128NUP133chr1229633882-PARPBPchr12102589728+0.0084685350.99153143
ENST00000537506ENST00000543784NUP133chr1229633882-PARPBPchr12102589728+0.0249077360.9750923

Top

Fusion Genomic Features for NUP133-PARPBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUP133chr1229633882-PARPBPchr12102589728+2.62E-050.9999738
NUP133chr1229633882-PARPBPchr12102589728+2.62E-050.9999738
NUP133chr1229633882-PARPBPchr12102589728+2.62E-050.9999738
NUP133chr1229633882-PARPBPchr12102589728+2.62E-050.9999738

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NUP133-PARPBP


check button Go to

FGviewer for the breakpoints of chr1:229633883-chr12:102589729

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for NUP133-PARPBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261396_ENST00000378128_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(transcript)=2481nt_BP=911nt
CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG
TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC
GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT
CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG
TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA
AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC
ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA
GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA
GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA
TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA
GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA
AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA
TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA
AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT
CTTATATGCTTTAGGTTTATGTATCTATAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTA
TTATTTTGGTCTACAGTGTATGTAAGGTTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAG
TTTAATGCACAGAGAAAGCATATCATTTCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTA
TAGTAGCAGTATGGGCTTCTCCTCCCATTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTT
GCCAACAAGGTCGGTAGACTCTTCCCAGCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCAC
ACAAAATTTATTAAGAAAAAAAGAATGGATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCC
CACATTTTTGGCAGGTGTAATTGAGCCATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAA
TGGTGGTAGGATGTAAGAATTGAATTTTGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCA
TCCCCAATTTCTCTCTTTTCTTGTGTTGATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAA
GGTTTTATAGCCAGATTCAGTGGCAGACCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTT
AGCTATCGTATTCGGAGTGGAACTATAATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTT
AAAAATACCTTAGATGCAAATTTATAGGAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGA
AATATCGTCAGTCGTCCTAATGCATATTGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTA

>In-frame_ENST00000261396_ENST00000378128_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(amino acids)=280AA_start in transcript=77_stop in transcript=919
MLLGVMFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFG
SSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAV
MVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGI

--------------------------------------------------------------
>In-frame_ENST00000261396_ENST00000543784_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(transcript)=1329nt_BP=911nt
CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG
TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC
GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT
CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG
TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA
AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC
ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA
GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA
GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA
TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA
GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA
AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA
TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA
AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT

>In-frame_ENST00000261396_ENST00000543784_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(amino acids)=280AA_start in transcript=77_stop in transcript=919
MLLGVMFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFG
SSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAV
MVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGI

--------------------------------------------------------------
>In-frame_ENST00000537506_ENST00000378128_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(transcript)=2448nt_BP=878nt
ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT
CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT
CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC
ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG
TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT
CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT
CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG
CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA
TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA
TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG
AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG
AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC
TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA
CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC
ATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTATGTAAGGTTAGTA
TGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCATATCATTTCAGTT
ACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCTCCTCCCATTGGCA
ATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACTCTTCCCAGCATAC
ATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAAAAGAATGGATCTA
GTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAATTGAGCCATGGTC
TTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAATTGAATTTTGAAAA
GACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTCTTGTGTTGATTCA
GTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAGTGGCAGACCATGA
TTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGGAACTATAATACAA
TTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAATTTATAGGAGAAA
AAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAATGCATATTGTGAC
TGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCATTGAAATAAACGAC

>In-frame_ENST00000537506_ENST00000378128_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(amino acids)=264AA_start in transcript=92_stop in transcript=886
MLLGVMGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEV
DDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLA

--------------------------------------------------------------
>In-frame_ENST00000537506_ENST00000543784_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(transcript)=1296nt_BP=878nt
ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT
CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT
CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC
ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG
TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT
CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT
CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG
CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA
TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA
TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG
AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG
AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC
TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA
CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC

>In-frame_ENST00000537506_ENST00000543784_TCGA-29-1691-01A_NUP133_chr1_229633883_-_PARPBP_chr12_102589729_length(amino acids)=264AA_start in transcript=92_stop in transcript=886
MLLGVMGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEV
DDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLA

--------------------------------------------------------------
>In-frame_ENST00000261396_ENST00000378128_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(transcript)=2481nt_BP=911nt
CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG
TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC
GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT
CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG
TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA
AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC
ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA
GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA
GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA
TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA
GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA
AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA
TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA
AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT
CTTATATGCTTTAGGTTTATGTATCTATAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTA
TTATTTTGGTCTACAGTGTATGTAAGGTTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAG
TTTAATGCACAGAGAAAGCATATCATTTCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTA
TAGTAGCAGTATGGGCTTCTCCTCCCATTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTT
GCCAACAAGGTCGGTAGACTCTTCCCAGCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCAC
ACAAAATTTATTAAGAAAAAAAGAATGGATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCC
CACATTTTTGGCAGGTGTAATTGAGCCATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAA
TGGTGGTAGGATGTAAGAATTGAATTTTGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCA
TCCCCAATTTCTCTCTTTTCTTGTGTTGATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAA
GGTTTTATAGCCAGATTCAGTGGCAGACCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTT
AGCTATCGTATTCGGAGTGGAACTATAATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTT
AAAAATACCTTAGATGCAAATTTATAGGAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGA
AATATCGTCAGTCGTCCTAATGCATATTGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTA

>In-frame_ENST00000261396_ENST00000378128_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(amino acids)=280AA_start in transcript=77_stop in transcript=919
MLLGVMFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFG
SSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAV
MVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGI

--------------------------------------------------------------
>In-frame_ENST00000261396_ENST00000543784_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(transcript)=1329nt_BP=911nt
CTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGTCGCTGCTCCTTGGAG
TCATGTTCCCAGCCGCCCCTTCTCCGCGGACCCCGGGTACCGGGTCCCGAAGGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCC
GGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGTCTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCT
CGCGGGGAACACCAACACGAATGTTCCCACACCACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTG
TTAAAGTCATGGAAGCCCTAACATTGGCTGAAGTCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCA
AAGAGAAGCTCATTATTTGGAAGATTGCTCTGTCACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCC
ACTGGAGTGCCGACTTAGTGGCTCTTTCTTACTCTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCA
GAGAAGGATCTATCCGCTATTGGCCAAGCCTTGCTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACA
GTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTATTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGA
TTCATCAGCATATCCTGCCTCAGGGGCAAGGCATGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTA
GTGATCTCACAAGGGTGTAAATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGA
AAAAGTATCAAGAAAATCAACCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGA
TAATAGAAATGAACCACCTCAACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAA
AGTAGCAAAAAGTAATAAATGTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGT

>In-frame_ENST00000261396_ENST00000543784_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(amino acids)=280AA_start in transcript=77_stop in transcript=919
MLLGVMFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFG
SSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAV
MVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGI

--------------------------------------------------------------
>In-frame_ENST00000537506_ENST00000378128_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(transcript)=2448nt_BP=878nt
ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT
CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT
CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC
ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG
TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT
CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT
CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG
CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA
TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA
TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG
AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG
AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC
TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA
CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC
ATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTATGTAAGGTTAGTA
TGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCATATCATTTCAGTT
ACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCTCCTCCCATTGGCA
ATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACTCTTCCCAGCATAC
ATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAAAAGAATGGATCTA
GTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAATTGAGCCATGGTC
TTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAATTGAATTTTGAAAA
GACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTCTTGTGTTGATTCA
GTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAGTGGCAGACCATGA
TTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGGAACTATAATACAA
TTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAATTTATAGGAGAAA
AAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAATGCATATTGTGAC
TGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCATTGAAATAAACGAC

>In-frame_ENST00000537506_ENST00000378128_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(amino acids)=264AA_start in transcript=92_stop in transcript=886
MLLGVMGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEV
DDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLA

--------------------------------------------------------------
>In-frame_ENST00000537506_ENST00000543784_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(transcript)=1296nt_BP=878nt
ATCATCGCGCGCCATCTCTTCCCTTAGGTGTTTAAGTTCCGCGCGCAGGCCAGGCTGCAACCTGACGGCCAGATCCCTCGCTGTCCTAGT
CGCTGCTCCTTGGAGTCATGGGCCCGCTGGCCGGACTCGGGCCCGGCTCCACGCCCCGGACGGCTAGCAGGAAGGGTCTGCCCCTGGGGT
CTGCAGTCAGCTCCCCAGTGCTCTTCTCGCCGGTCGGCCGGCGTAGCTCGCTAAGCTCGCGGGGAACACCAACACGAATGTTCCCACACC
ACTCCATAACTGAGTCTGTGAACTATGATGTGAAAACGTTTGGATCTTCTCTTCCTGTTAAAGTCATGGAAGCCCTAACATTGGCTGAAG
TCGATGACCAGCTGACCATTAACATAGATGAAGGTGGATGGGCTTGTCTGGTGTGCAAAGAGAAGCTCATTATTTGGAAGATTGCTCTGT
CACCTATTACTAAGTTATCCGTTTGCAAAGAACTTCAGCTGCCACCTAGTGATTTCCACTGGAGTGCCGACTTAGTGGCTCTTTCTTACT
CTTCTCCCTCAGGTGAAGCACATTCTACTCAGGCTGTTGCTGTCATGGTTGCCACCAGAGAAGGATCTATCCGCTATTGGCCAAGCCTTG
CTGGTGAAGATACCTACACAGAGGCTTTTGTAGATTCGGGAGGTGATAAGACTTACAGTTTCCTAACAGCAGTGCAGGGAGGAAGTTTTA
TTTTGTCTTCATCAGGAAGCCAACTAATTCGGTTGATACCTGAGAGCTCAGGAAAGATTCATCAGCATATCCTGCCTCAGGGGCAAGGCA
TGCTTTCAGGAATTGGTCGAAAAGTTTCTTCTCTTTTTGGAATTTTATCTCCTAGTAGTGATCTCACAAGGGTGTAAATCCATCTGTTGG
AAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCAGACAGG
AAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAAAAATGC
TAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGCCAAGGA
CAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTATAAACC

>In-frame_ENST00000537506_ENST00000543784_TCGA-29-1691_NUP133_chr1_229633882_-_PARPBP_chr12_102589728_length(amino acids)=264AA_start in transcript=92_stop in transcript=886
MLLGVMGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEV
DDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NUP133-PARPBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NUP133-PARPBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NUP133-PARPBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP133C4748549NEPHROTIC SYNDROME, TYPE 182GENOMICS_ENGLAND;UNIPROT
HgeneNUP133C0795949Galloway Mowat syndrome1ORPHANET
HgeneNUP133C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET