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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUP205-TPM1 (FusionGDB2 ID:60646)

Fusion Gene Summary for NUP205-TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP205-TPM1
Fusion gene ID: 60646
HgeneTgene
Gene symbol

NUP205

TPM1

Gene ID

23165

7168

Gene namenucleoporin 205tropomyosin 1
SynonymsC7orf14|NPHS13C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

7q33

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup205205 kDa nucleoporinnucleoporin Nup205tropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappa
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000285968, ENST00000440390, 
ENST00000489493, 		ENST00000288398, 
ENST00000358278, ENST00000560445, 
ENST00000403994, ENST00000357980, 
ENST00000559556, ENST00000559397, 
ENST00000267996, ENST00000334895, 
ENST00000404484, ENST00000560959, 
ENST00000559281, ENST00000317516, 
Fusion gene scores* DoF score8 X 9 X 7=50414 X 8 X 8=896
# samples 916
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/896*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP205 [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP205(135269755)-TPM1(63349184), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NUP205 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364-01ANUP205chr7

135269755

+TPM1chr15

63349184

+


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Fusion Gene ORF analysis for NUP205-TPM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000285968ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000285968ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000440390ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000440390ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-3CDSENST00000489493ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-3CDSENST00000489493ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285968NUP205chr7135269755+ENST00000288398TPM1chr1563349184+21011244261858610
ENST00000285968NUP205chr7135269755+ENST00000358278TPM1chr1563349184+25761244261858610
ENST00000440390NUP205chr7135269755+ENST00000288398TPM1chr1563349184+206012036031817404
ENST00000440390NUP205chr7135269755+ENST00000358278TPM1chr1563349184+253512036031817404

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285968ENST00000288398NUP205chr7135269755+TPM1chr1563349184+0.0078216380.9921783
ENST00000285968ENST00000358278NUP205chr7135269755+TPM1chr1563349184+0.0029495470.9970504
ENST00000440390ENST00000288398NUP205chr7135269755+TPM1chr1563349184+0.0021110010.997889
ENST00000440390ENST00000358278NUP205chr7135269755+TPM1chr1563349184+0.0006336270.99936634

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Fusion Genomic Features for NUP205-TPM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUP205chr7135269755+TPM1chr1563349183+1.47E-121
NUP205chr7135269755+TPM1chr1563349183+1.47E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUP205-TPM1


check button Go to

FGviewer for the breakpoints of chr7:135269755-chr15:63349184

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPM1chr7:135269755chr15:63349184ENST00000267996191_28480.0285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST000002883981101_28480.0247.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000334895081_28444.0246.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000358278191_28480.0285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST000004039941101_28480.0285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000559397191_28480.0285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000559556191_28480.0285.0Coiled coilOntology_term=ECO:0000250


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Fusion Gene Sequence for NUP205-TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000285968_ENST00000288398_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(transcript)=2101nt_BP=1244nt
AAGGGCTCTGTTAGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGC
ATAAAGTGGGAAATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCT
CATTGTTCAAAAATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGG
GAACTCGACTTCTTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTC
TTCTTGCTGGAGAGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCA
TTGCGAATTCCTTGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACAC
GCTTTACAGATGAGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAAC
TACAGCGAGAGAGAGGTTTGGGCAGTGAAAAACATCGCAAAGAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCC
TTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGACACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATG
GCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTTCTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAG
ATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAGTACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAAC
TGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTGGCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAAT
TCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCTGACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACT
TTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTCATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAG
CTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAG
CTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGA
TCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACC
TGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAG
CATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTG
AGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGA
AGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAACGATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTG
CCCTCATGCTAATATAAGTTTCTTTGCTTCACTTCTCCCAAGACTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGT
CTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTGCCTTAGAGCCAGGCACACACTGTGCTTTCTATTGTACAGAAGCTCTTCG

>In-frame_ENST00000285968_ENST00000288398_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(amino acids)=610AA_start in transcript=26_stop in transcript=1858
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKNVQQHEKVQKASTEGVAIQGQQGTRLLPEQL
IKEAFILSDLFDIGELAAVELLLAGEHQQPHFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLA
LLMALLYCFDISFIEQSTEERDDMIHQLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE
RGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKY

--------------------------------------------------------------
>In-frame_ENST00000285968_ENST00000358278_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(transcript)=2576nt_BP=1244nt
AAGGGCTCTGTTAGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGC
ATAAAGTGGGAAATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCT
CATTGTTCAAAAATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGG
GAACTCGACTTCTTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTC
TTCTTGCTGGAGAGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCA
TTGCGAATTCCTTGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACAC
GCTTTACAGATGAGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAAC
TACAGCGAGAGAGAGGTTTGGGCAGTGAAAAACATCGCAAAGAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCC
TTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGACACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATG
GCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTTCTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAG
ATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAGTACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAAC
TGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTGGCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAAT
TCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCTGACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACT
TTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTCATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAG
CTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAG
CTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGA
TCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACC
TGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAG
CATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTG
AGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAG
AAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTGGAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCG
TTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAAATGCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATAC
CAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCAAGCCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGA
TGCTGCCACACTTTGTAGAGAGTTTAGCAACACAGTGTGCTTAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGT
GCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACACAATCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTC
TTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACTAATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGC
ATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGCCACGCTGCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCAT
GACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTTTTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGG

>In-frame_ENST00000285968_ENST00000358278_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(amino acids)=610AA_start in transcript=26_stop in transcript=1858
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKNVQQHEKVQKASTEGVAIQGQQGTRLLPEQL
IKEAFILSDLFDIGELAAVELLLAGEHQQPHFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLA
LLMALLYCFDISFIEQSTEERDDMIHQLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE
RGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKY

--------------------------------------------------------------
>In-frame_ENST00000440390_ENST00000288398_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(transcript)=2060nt_BP=1203nt
AGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGCATAAAGTGGGAA
ATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCTCATTGTTCAAAA
ATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGGGAACTCGACTTC
TTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTCTTCTTGCTGGAG
AGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCATTGCGAATTCCT
TGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACACGCTTTACAGATG
AGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAACTACAGCGAGAGA
GAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCCTTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGAC
ACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATGGCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTT
CTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAGATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAG
TACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAACTGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTG
GCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAATTCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCT
GACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACTTTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTC
ATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTG
GATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTC
ATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGAC
CGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAA
GTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGAC
AGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTG
GAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAAC
GATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTGCCCTCATGCTAATATAAGTTTCTTTGCTTCACTTCTCCCAA
GACTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGTCTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTG

>In-frame_ENST00000440390_ENST00000288398_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(amino acids)=404AA_start in transcript=603_stop in transcript=1817
MSLRNYSEREVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIH
QLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMAELAIADNVFLFLMESVVVSEYFYQEE
FYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE
AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE

--------------------------------------------------------------
>In-frame_ENST00000440390_ENST00000358278_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(transcript)=2535nt_BP=1203nt
AGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGCATAAAGTGGGAA
ATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCTCATTGTTCAAAA
ATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGGGAACTCGACTTC
TTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTCTTCTTGCTGGAG
AGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCATTGCGAATTCCT
TGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACACGCTTTACAGATG
AGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAACTACAGCGAGAGA
GAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCCTTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGAC
ACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATGGCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTT
CTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAGATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAG
TACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAACTGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTG
GCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAATTCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCT
GACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACTTTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTC
ATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTG
GATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTC
ATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGAC
CGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAA
GTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGAC
AGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTG
GAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTG
GAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCGTTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAA
ATGCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATACCAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCA
AGCCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCACACTTTGTAGAGAGTTTAGCAACACAGTGTGCT
TAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGTGCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACAC
AATCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTCTTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACT
AATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGCCACGCT
GCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCATGACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTT
TTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGGACGTTTTCTTGAGAGTTTTAACTATATGTAAACATTGTATA

>In-frame_ENST00000440390_ENST00000358278_TCGA-BR-8364-01A_NUP205_chr7_135269755_+_TPM1_chr15_63349184_length(amino acids)=404AA_start in transcript=603_stop in transcript=1817
MSLRNYSEREVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIH
QLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMAELAIADNVFLFLMESVVVSEYFYQEE
FYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE
AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUP205-TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUP205-TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUP205-TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP205C0029401Osteitis Deformans1CTD_human
HgeneNUP205C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1CTD_human;ORPHANET
HgeneNUP205C4225165NEPHROTIC SYNDROME, TYPE 131CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM1C0007194Hypertrophic Cardiomyopathy18CLINGEN
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneTPM1C0546837Malignant neoplasm of esophagus1CTD_human
TgeneTPM1C0597124Obstructive asymmetric septal hypertrophy1CTD_human
TgeneTPM1C0700053Idiopathic hypertrophic subaortic stenosis1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human
TgeneTPM1C1960469Left ventricular noncompaction1ORPHANET