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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NVL-NEK2 (FusionGDB2 ID:60796)

Fusion Gene Summary for NVL-NEK2

check button Fusion gene summary
Fusion gene informationFusion gene name: NVL-NEK2
Fusion gene ID: 60796
HgeneTgene
Gene symbol

NVL

NEK2

Gene ID

4931

4751

Gene namenuclear VCP likeNIMA related kinase 2
SynonymsNVL2HsPK21|NEK2A|NLK1|PPP1R111|RP67
Cytomap

1q42.11

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear valosin-containing protein-likeNVLpserine/threonine-protein kinase Nek2NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111
Modification date2020031320200313
UniProtAcc.

P51955

Ensembl transtripts involved in fusion geneENST00000391875, ENST00000281701, 
ENST00000469075, ENST00000482491, 
ENST00000340871, ENST00000361463, 
ENST00000468673, 		ENST00000366999, 
ENST00000540251, ENST00000462283, 
ENST00000366998, 
Fusion gene scores* DoF score11 X 11 X 8=9683 X 4 X 3=36
# samples 124
** MAII scorelog2(12/968*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NVL [Title/Abstract] AND NEK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNVL(224437914)-NEK2(211847855), # samples:3
Anticipated loss of major functional domain due to fusion event.NVL-NEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NVL-NEK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNVL

GO:0006364

rRNA processing

29107693

HgeneNVL

GO:0032092

positive regulation of protein binding

29107693

HgeneNVL

GO:0042273

ribosomal large subunit biogenesis

26166824

HgeneNVL

GO:1904749

regulation of protein localization to nucleolus

29107693

TgeneNEK2

GO:0006468

protein phosphorylation

21076410

TgeneNEK2

GO:0007059

chromosome segregation

14978040

TgeneNEK2

GO:0046777

protein autophosphorylation

17626005

TgeneNEK2

GO:0051299

centrosome separation

18086858


check buttonFusion gene breakpoints across NVL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NEK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09Q-01ANVLchr1

224437914

-NEK2chr1

211847855

-
ChimerDB4BRCATCGA-A8-A09QNVLchr1

224437913

-NEK2chr1

211847855

-
ChimerDB4BRCATCGA-A8-A09Q-01ANVLchr1

224437914

-NEK2chr1

211847855

-
ChimerDB4BRCATCGA-A8-A09Q-01ANVLchr1

224437914

-NEK2chr1

211847855

-


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Fusion Gene ORF analysis for NVL-NEK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000391875ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-5UTRENST00000391875ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000391875ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000391875ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
In-frameENST00000281701ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-5UTRENST00000281701ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000281701ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000281701ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
In-frameENST00000469075ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-5UTRENST00000469075ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000469075ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000469075ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
Frame-shiftENST00000482491ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-5UTRENST00000482491ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000482491ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000482491ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
Frame-shiftENST00000340871ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-5UTRENST00000340871ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000340871ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
5CDS-intronENST00000340871ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
3UTR-3CDSENST00000361463ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
3UTR-5UTRENST00000361463ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
3UTR-intronENST00000361463ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
3UTR-intronENST00000361463ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
intron-3CDSENST00000468673ENST00000366999NVLchr1

224437914

-NEK2chr1

211847855

-
intron-5UTRENST00000468673ENST00000540251NVLchr1

224437914

-NEK2chr1

211847855

-
intron-intronENST00000468673ENST00000462283NVLchr1

224437914

-NEK2chr1

211847855

-
intron-intronENST00000468673ENST00000366998NVLchr1

224437914

-NEK2chr1

211847855

-
In-frameENST00000391875ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-5UTRENST00000391875ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000391875ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000391875ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
In-frameENST00000281701ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-5UTRENST00000281701ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000281701ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000281701ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
In-frameENST00000469075ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-5UTRENST00000469075ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000469075ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000469075ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
Frame-shiftENST00000482491ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-5UTRENST00000482491ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000482491ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000482491ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
Frame-shiftENST00000340871ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-5UTRENST00000340871ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000340871ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
5CDS-intronENST00000340871ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
3UTR-3CDSENST00000361463ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
3UTR-5UTRENST00000361463ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
3UTR-intronENST00000361463ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
3UTR-intronENST00000361463ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-
intron-3CDSENST00000468673ENST00000366999NVLchr1

224437913

-NEK2chr1

211847855

-
intron-5UTRENST00000468673ENST00000540251NVLchr1

224437913

-NEK2chr1

211847855

-
intron-intronENST00000468673ENST00000462283NVLchr1

224437913

-NEK2chr1

211847855

-
intron-intronENST00000468673ENST00000366998NVLchr1

224437913

-NEK2chr1

211847855

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391875NVLchr1224437914-ENST00000366999NEK2chr1211847855-415422585634991147
ENST00000281701NVLchr1224437914-ENST00000366999NEK2chr1211847855-4445254922437901188
ENST00000469075NVLchr1224437914-ENST00000366999NEK2chr1211847855-392320271132681085
ENST00000391875NVLchr1224437913-ENST00000366999NEK2chr1211847855-415422585634991147
ENST00000281701NVLchr1224437913-ENST00000366999NEK2chr1211847855-4445254922437901188
ENST00000469075NVLchr1224437913-ENST00000366999NEK2chr1211847855-392320271132681085

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391875ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002621490.9997378
ENST00000281701ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002301010.99976987
ENST00000469075ENST00000366999NVLchr1224437914-NEK2chr1211847855-0.0002870450.9997129
ENST00000391875ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002621490.9997378
ENST00000281701ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002301010.99976987
ENST00000469075ENST00000366999NVLchr1224437913-NEK2chr1211847855-0.0002870450.9997129

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Fusion Genomic Features for NVL-NEK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NVL-NEK2


check button Go to

FGviewer for the breakpoints of chr1:224437914-chr1:211847855

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEK2

P51955

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923218_232763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-192349_52763.0857.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-192385_88763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721218_232574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-172149_52574.0668.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-172185_88574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822218_232657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-182249_52657.0751.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-182285_88657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822218_232672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-182249_52672.0766.0MotifNucleolar localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-182285_88672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923218_232763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-192349_52763.0857.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-192385_88763.0857.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721218_232574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-172149_52574.0668.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-172185_88574.0668.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822218_232657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-182249_52657.0751.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-182285_88657.0751.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822218_232672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-182249_52672.0766.0MotifNucleolar localization signal
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-182285_88672.0766.0MotifNuclear localization signal
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923305_312763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923622_629763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721305_312574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822305_312657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822622_629657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822305_312672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822622_629672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923305_312763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923622_629763.0857.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721305_312574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822305_312657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822622_629657.0751.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822305_312672.0766.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822622_629672.0766.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807303_36232.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807406_43032.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908303_36232.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908406_43032.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807303_36232.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807406_43032.0385.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908303_36232.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908406_43032.0446.0Coiled coilOntology_term=ECO:0000255
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807306_33432.0385.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807333_37032.0385.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908306_33432.0446.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908333_37032.0446.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807306_33432.0385.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807333_37032.0385.0RegionNote=Required for microtubule binding and for localization to the centrosomes
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908306_33432.0446.0RegionNote=Leucine-zipper
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908333_37032.0446.0RegionNote=Required for microtubule binding and for localization to the centrosomes

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721622_629574.0668.0Nucleotide bindingATP
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721622_629574.0668.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST00000366998078_27132.0385.0DomainProtein kinase
TgeneNEK2chr1:224437913chr1:211847855ENST00000366999088_27132.0446.0DomainProtein kinase
TgeneNEK2chr1:224437914chr1:211847855ENST00000366998078_27132.0385.0DomainProtein kinase
TgeneNEK2chr1:224437914chr1:211847855ENST00000366999088_27132.0446.0DomainProtein kinase
TgeneNEK2chr1:224437913chr1:211847855ENST000003669980714_2232.0385.0Nucleotide bindingATP
TgeneNEK2chr1:224437913chr1:211847855ENST000003669990814_2232.0446.0Nucleotide bindingATP
TgeneNEK2chr1:224437914chr1:211847855ENST000003669980714_2232.0385.0Nucleotide bindingATP
TgeneNEK2chr1:224437914chr1:211847855ENST000003669990814_2232.0446.0Nucleotide bindingATP


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Fusion Gene Sequence for NVL-NEK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000391875_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(transcript)=4154nt_BP=2258nt
CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG
AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG
AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT
CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA
ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC
CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT
CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG
GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTA
AAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGC
TCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGA
AGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAG
AGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACCC
CCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTA
CAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATAT
GCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTC
ACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAA
TGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCA
CTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCA
TTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGG
CAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTG
GATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGAC
TAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCA
AGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAG
TGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTG
ACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTA
TCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTC
GTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTG
AAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGT
TGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGG
ATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACAC
CTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTAT
GTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTT
ACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTT
TAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCA
GCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGA
AAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGG
AACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAA
GTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACCTGAAGAAAAGGCTTCACGCTG
CCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGAAAAGCAGACAGATCCTGGGCATGCGCTAGCCAGGTAGAG
AGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGATATTCAAATGCTGTAGTGTTGAATACTTGGTTCCATGAGC
CATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTCTTCAGCAACTATTGTACAAAATGTTCACATTTAATTTTT
CTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCTTTTAATCCTGTGTGTGATTACTAGTAGGAACATGAGATG
TGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTATGCAGGAAGAGTAGCACTCACTGAATAGTTTTAAATGACT
GAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGCTTAGAAAACCCAGTTAGATGC
AATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCTGTAGTTCAAATCTGTTAGCTTTGTGAAAATTCATCACTG
TGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTGTCATTTACCTACTTCTTTCCCACTAAATAAAAGAATTCT

>In-frame_ENST00000391875_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(amino acids)=1147AA_start in transcript=56_stop in transcript=3499
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLP
PPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYL
DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSD
IWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGR
QLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSS

--------------------------------------------------------------
>In-frame_ENST00000281701_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(transcript)=4445nt_BP=2549nt
AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT
TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC
GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA
GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG
TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA
GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA
ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC
TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA
GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG
ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG
AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG
CTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACAT
TAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC
ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGA
TTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTG
ATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATG
ATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGG
GAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC
CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGT
GTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGG
AAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGG
AGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCA
CTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC
CAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGG
CTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGC
GACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAG
AGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCA
CTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATC
GCCTTGCCATCTTAAAAACTATCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTG
TTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGT
ACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTG
TTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGA
AACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTG
CAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGG
GCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAAT
TCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTG
AAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGC
CAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAA
GAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGA
AGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGA
AAGTTCATTTCAGTGGGGAAAGTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACC
TGAAGAAAAGGCTTCACGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGAAAAGCAGACAGATCCTGG
GCATGCGCTAGCCAGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGATATTCAAATGCTGTAGTGT
TGAATACTTGGTTCCATGAGCCATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTCTTCAGCAACTATTGTACA
AAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCTTTTAATCCTGTGTGTGAT
TACTAGTAGGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTATGCAGGAAGAGTAGCACTC
ACTGAATAGTTTTAAATGACTGAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGC
TTAGAAAACCCAGTTAGATGCAATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCTGTAGTTCAAATCTGTTAG
CTTTGTGAAAATTCATCACTGTGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTGTCATTTACCTACTTCTTT

>In-frame_ENST00000281701_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(amino acids)=1188AA_start in transcript=224_stop in transcript=3790
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI
VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKL
GDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI
ITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVR
ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQAL

--------------------------------------------------------------
>In-frame_ENST00000469075_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(transcript)=3923nt_BP=2027nt
AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG
GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA
TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG
CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA
AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG
TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGG
GAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCC
CTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGA
AAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCAC
CATGTATCATTTTCATTGATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAAC
TCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACC
CTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGT
GCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGT
GCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCAT
CTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACC
AAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCA
AAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATAT
TGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGA
AGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTG
AGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTC
CTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGG
TTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTT
TACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAG
CTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACC
GGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAAT
ACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCG
TATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAA
ACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAAT
CAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGA
AAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATT
ACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAG
GGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAG
AGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTA
GAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCAT
CCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAAGTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTA
AGTCCAAGTGCAAGGACCTGAAGAAAAGGCTTCACGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGA
AAAGCAGACAGATCCTGGGCATGCGCTAGCCAGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGAT
ATTCAAATGCTGTAGTGTTGAATACTTGGTTCCATGAGCCATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTC
TTCAGCAACTATTGTACAAAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCT
TTTAATCCTGTGTGTGATTACTAGTAGGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTAT
GCAGGAAGAGTAGCACTCACTGAATAGTTTTAAATGACTGAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGA
TTTTAAATGTTTTTGAGCTTAGAAAACCCAGTTAGATGCAATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCT
GTAGTTCAAATCTGTTAGCTTTGTGAAAATTCATCACTGTGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTG

>In-frame_ENST00000469075_ENST00000366999_TCGA-A8-A09Q-01A_NVL_chr1_224437914_-_NEK2_chr1_211847855_length(amino acids)=1085AA_start in transcript=11_stop in transcript=3268
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNT
TLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT
SFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP
SVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAEN
LLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQ

--------------------------------------------------------------
>In-frame_ENST00000391875_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(transcript)=4154nt_BP=2258nt
CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG
AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG
AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT
CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA
ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC
CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT
CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG
GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTA
AAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGC
TCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGA
AGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAG
AGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACCC
CCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTA
CAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATAT
GCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTC
ACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAA
TGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCA
CTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCA
TTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGG
CAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTG
GATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGAC
TAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCA
AGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAG
TGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTG
ACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTA
TCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTC
GTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGTACATTGTAATGGAATATTGTG
AAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGT
TGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGG
ATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACAC
CTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTAT
GTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTT
ACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTT
TAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCA
GCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGA
AAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGG
AACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAA
GTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACCTGAAGAAAAGGCTTCACGCTG
CCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGAAAAGCAGACAGATCCTGGGCATGCGCTAGCCAGGTAGAG
AGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGATATTCAAATGCTGTAGTGTTGAATACTTGGTTCCATGAGC
CATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTCTTCAGCAACTATTGTACAAAATGTTCACATTTAATTTTT
CTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCTTTTAATCCTGTGTGTGATTACTAGTAGGAACATGAGATG
TGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTATGCAGGAAGAGTAGCACTCACTGAATAGTTTTAAATGACT
GAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGCTTAGAAAACCCAGTTAGATGC
AATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCTGTAGTTCAAATCTGTTAGCTTTGTGAAAATTCATCACTG
TGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTGTCATTTACCTACTTCTTTCCCACTAAATAAAAGAATTCT

>In-frame_ENST00000391875_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(amino acids)=1147AA_start in transcript=56_stop in transcript=3499
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLP
PPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYL
DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSD
IWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGR
QLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSS

--------------------------------------------------------------
>In-frame_ENST00000281701_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(transcript)=4445nt_BP=2549nt
AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT
TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC
GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA
GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG
TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA
GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA
ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC
TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA
GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG
ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG
AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG
CTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACAT
TAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC
ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGA
TTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTG
ATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATG
ATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGG
GAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC
CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGT
GTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGG
AAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGG
AGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCA
CTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC
CAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGG
CTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGC
GACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAG
AGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCA
CTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATC
GCCTTGCCATCTTAAAAACTATCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTG
TTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACAACACTGT
ACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTG
TTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGGGATCTGA
AACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAAACCATGACACGAGTTTTG
CAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGGTCATTGG
GCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAAT
TCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCTTCTGTTG
AAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGC
CAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTCAAAGCAA
GAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGA
AGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCATCCTCAGTAATTAAGAAGA
AAGTTCATTTCAGTGGGGAAAGTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCAAGTGCAAGGACC
TGAAGAAAAGGCTTCACGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGAAAAGCAGACAGATCCTGG
GCATGCGCTAGCCAGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGATATTCAAATGCTGTAGTGT
TGAATACTTGGTTCCATGAGCCATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTCTTCAGCAACTATTGTACA
AAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCTTTTAATCCTGTGTGTGAT
TACTAGTAGGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTATGCAGGAAGAGTAGCACTC
ACTGAATAGTTTTAAATGACTGAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGATTTTAAATGTTTTTGAGC
TTAGAAAACCCAGTTAGATGCAATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCTGTAGTTCAAATCTGTTAG
CTTTGTGAAAATTCATCACTGTGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTGTCATTTACCTACTTCTTT

>In-frame_ENST00000281701_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(amino acids)=1188AA_start in transcript=224_stop in transcript=3790
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI
VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKL
GDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI
ITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVR
ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQAL

--------------------------------------------------------------
>In-frame_ENST00000469075_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(transcript)=3923nt_BP=2027nt
AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG
GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA
TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG
CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA
AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG
TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGG
GAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCC
CTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGA
AAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCAC
CATGTATCATTTTCATTGATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAAC
TCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACC
CTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGT
GCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGT
GCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCAT
CTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACC
AAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCA
AAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATAT
TGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGA
AGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTG
AGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTC
CTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGG
TTTTTATTATGGCAGCCACTAACAGGCCAGATATAATTGACCCTGCAATCCTGCGCCCGGGCCGCCTGGACAAAACACTGTTTGTGGGTT
TACCGCCCCCTGCAGATCGCCTTGCCATCTTAAAAACTATCACAAAAATATTAGTTTGGAAAGAACTTGACTATGGCTCCATGACAGAAG
CTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGTGAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACC
GGACCAATACAACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAGGGAACCAAGGAAAGGCAAT
ACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTGACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCG
TATTGCATCGGGATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTTGGGCTAGCTAGAATATTAA
ACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCTTATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAAT
CAGATATCTGGTCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGCCAGAAAGAACTCGCTGGGA
AAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTACTCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATT
ACCATCGACCTTCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGAAGAAATCTTGAGAGAAGAG
GGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGCCCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAG
AGCGAGCTCTCAAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTAGCAGAGGACAAACTGGCTA
GAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAACGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAACTTCTTAATCTTCCAT
CCTCAGTAATTAAGAAGAAAGTTCATTTCAGTGGGGAAAGTAAAGAGAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTA
AGTCCAAGTGCAAGGACCTGAAGAAAAGGCTTCACGCTGCCCAGCTGCGGGCTCAAGCCCTGTCAGATATTGAGAAAAATTACCAACTGA
AAAGCAGACAGATCCTGGGCATGCGCTAGCCAGGTAGAGAGACACAGAGCTGTGTACAGGATGTAATATTACCAACCTTTAAAGACTGAT
ATTCAAATGCTGTAGTGTTGAATACTTGGTTCCATGAGCCATGCCTTTCTGTATAGTACACATGATATTTCGGAATTGGTTTTACTGTTC
TTCAGCAACTATTGTACAAAATGTTCACATTTAATTTTTCTTTCTTCTTTTAAGAACATATTATAAAAAGAATACTTTCTTGGTTGGGCT
TTTAATCCTGTGTGTGATTACTAGTAGGAACATGAGATGTGACATTCTAAATCTTGGGAGAAAAAATAATGTTAGGAAAAAAATATTTAT
GCAGGAAGAGTAGCACTCACTGAATAGTTTTAAATGACTGAGTGGTATGCTTACAATTGTCATGTCTAGATTTAAATTTTAAGTCTGAGA
TTTTAAATGTTTTTGAGCTTAGAAAACCCAGTTAGATGCAATTTGGTCATTAATACCATGACATCTTGCTTATAAATATTCCATTGCTCT
GTAGTTCAAATCTGTTAGCTTTGTGAAAATTCATCACTGTGATGTTTGTATTCTTTTTTTTTTTCTGTTTAACAGAATATGAGCTGTCTG

>In-frame_ENST00000469075_ENST00000366999_TCGA-A8-A09Q_NVL_chr1_224437913_-_NEK2_chr1_211847855_length(amino acids)=1085AA_start in transcript=11_stop in transcript=3268
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNT
TLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT
SFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP
SVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAEN
LLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQ

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Fusion Gene PPI Analysis for NVL-NEK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-19231_220763.0857.0RPL5
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-17211_220574.0668.0RPL5
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-18221_220657.0751.0RPL5
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-18221_220672.0766.0RPL5
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-19231_220763.0857.0RPL5
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-17211_220574.0668.0RPL5
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-18221_220657.0751.0RPL5
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-18221_220672.0766.0RPL5
HgeneNVLchr1:224437913chr1:211847855ENST00000281701-1923267_474763.0857.0WDR74
HgeneNVLchr1:224437913chr1:211847855ENST00000340871-1721267_474574.0668.0WDR74
HgeneNVLchr1:224437913chr1:211847855ENST00000391875-1822267_474657.0751.0WDR74
HgeneNVLchr1:224437913chr1:211847855ENST00000469075-1822267_474672.0766.0WDR74
HgeneNVLchr1:224437914chr1:211847855ENST00000281701-1923267_474763.0857.0WDR74
HgeneNVLchr1:224437914chr1:211847855ENST00000340871-1721267_474574.0668.0WDR74
HgeneNVLchr1:224437914chr1:211847855ENST00000391875-1822267_474657.0751.0WDR74
HgeneNVLchr1:224437914chr1:211847855ENST00000469075-1822267_474672.0766.0WDR74
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807301_44532.0385.0CEP85
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908301_44532.0446.0CEP85
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807301_44532.0385.0CEP85
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908301_44532.0446.0CEP85
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807264_44532.0385.0PCNT
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908264_44532.0446.0PCNT
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807264_44532.0385.0PCNT
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908264_44532.0446.0PCNT
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699807403_43932.0385.0SAV1 and STK3/MST2
TgeneNEK2chr1:224437913chr1:211847855ENST0000036699908403_43932.0446.0SAV1 and STK3/MST2
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699807403_43932.0385.0SAV1 and STK3/MST2
TgeneNEK2chr1:224437914chr1:211847855ENST0000036699908403_43932.0446.0SAV1 and STK3/MST2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NVL-NEK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNEK2P51955DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for NVL-NEK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNEK2C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNEK2C0027626Neoplasm Invasiveness1CTD_human
TgeneNEK2C0035334Retinitis Pigmentosa1ORPHANET
TgeneNEK2C2239176Liver carcinoma1CTD_human