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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NVL-ZPBP2 (FusionGDB2 ID:60801)

Fusion Gene Summary for NVL-ZPBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NVL-ZPBP2
Fusion gene ID: 60801
HgeneTgene
Gene symbol

NVL

ZPBP2

Gene ID

4931

124626

Gene namenuclear VCP likezona pellucida binding protein 2
SynonymsNVL2ZPBPL
Cytomap

1q42.11

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear valosin-containing protein-likeNVLpzona pellucida-binding protein 2ZPBP-like protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000391875, ENST00000281701, 
ENST00000469075, ENST00000482491, 
ENST00000340871, ENST00000361463, 
ENST00000468673, 		ENST00000348931, 
ENST00000584588, ENST00000377940, 
Fusion gene scores* DoF score11 X 11 X 8=9688 X 8 X 6=384
# samples 1211
** MAII scorelog2(12/968*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/384*10)=-1.8036027871965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NVL [Title/Abstract] AND ZPBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNVL(224455736)-ZPBP2(38026947), # samples:2
Anticipated loss of major functional domain due to fusion event.NVL-ZPBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNVL

GO:0006364

rRNA processing

29107693

HgeneNVL

GO:0032092

positive regulation of protein binding

29107693

HgeneNVL

GO:0042273

ribosomal large subunit biogenesis

26166824

HgeneNVL

GO:1904749

regulation of protein localization to nucleolus

29107693


check buttonFusion gene breakpoints across NVL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZPBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A3JP-01ANVLchr1

224455736

-ZPBP2chr17

38026947

+
ChimerDB4UCECTCGA-D1-A3JP-01ANVLchr1

224455736

-ZPBP2chr17

38026947

+


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Fusion Gene ORF analysis for NVL-ZPBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000391875ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000391875ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000391875ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000281701ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000281701ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000281701ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000469075ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000469075ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
In-frameENST00000469075ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000482491ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000482491ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000482491ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000340871ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000340871ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
Frame-shiftENST00000340871ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000361463ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000361463ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000361463ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000468673ENST00000348931NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000468673ENST00000584588NVLchr1

224455736

-ZPBP2chr17

38026947

+
intron-3CDSENST00000468673ENST00000377940NVLchr1

224455736

-ZPBP2chr17

38026947

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391875NVLchr1224455736-ENST00000348931ZPBP2chr1738026947+33852151563049997
ENST00000391875NVLchr1224455736-ENST00000584588ZPBP2chr1738026947+31712151562830924
ENST00000391875NVLchr1224455736-ENST00000377940ZPBP2chr1738026947+41372151563049997
ENST00000281701NVLchr1224455736-ENST00000348931ZPBP2chr1738026947+3676244222433401038
ENST00000281701NVLchr1224455736-ENST00000584588ZPBP2chr1738026947+346224422243121965
ENST00000281701NVLchr1224455736-ENST00000377940ZPBP2chr1738026947+4428244222433401038
ENST00000469075NVLchr1224455736-ENST00000348931ZPBP2chr1738026947+31541920112818935
ENST00000469075NVLchr1224455736-ENST00000584588ZPBP2chr1738026947+29401920112599862
ENST00000469075NVLchr1224455736-ENST00000377940ZPBP2chr1738026947+39061920112818935

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391875ENST00000348931NVLchr1224455736-ZPBP2chr1738026947+0.0004706110.99952936
ENST00000391875ENST00000584588NVLchr1224455736-ZPBP2chr1738026947+0.0006684350.9993316
ENST00000391875ENST00000377940NVLchr1224455736-ZPBP2chr1738026947+0.000251840.9997482
ENST00000281701ENST00000348931NVLchr1224455736-ZPBP2chr1738026947+9.11E-050.9999089
ENST00000281701ENST00000584588NVLchr1224455736-ZPBP2chr1738026947+0.0001150830.99988496
ENST00000281701ENST00000377940NVLchr1224455736-ZPBP2chr1738026947+5.21E-050.9999479
ENST00000469075ENST00000348931NVLchr1224455736-ZPBP2chr1738026947+0.0001515840.99984837
ENST00000469075ENST00000584588NVLchr1224455736-ZPBP2chr1738026947+0.000221290.9997787
ENST00000469075ENST00000377940NVLchr1224455736-ZPBP2chr1738026947+7.90E-050.99992096

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Fusion Genomic Features for NVL-ZPBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NVLchr1224455735-ZPBP2chr1738026946+1.27E-060.9999987
NVLchr1224455735-ZPBP2chr1738026946+1.27E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NVL-ZPBP2


check button Go to

FGviewer for the breakpoints of chr1:224455736-chr17:38026947

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-1823218_232727.3333333333334857.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-182349_52727.3333333333334857.0MotifNucleolar localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-182385_88727.3333333333334857.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-1621218_232538.3333333333334668.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-162149_52538.3333333333334668.0MotifNucleolar localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-162185_88538.3333333333334668.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-1722218_232621.3333333333334751.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-172249_52621.3333333333334751.0MotifNucleolar localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-172285_88621.3333333333334751.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-1722218_232636.3333333333334766.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-172249_52636.3333333333334766.0MotifNucleolar localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-172285_88636.3333333333334766.0MotifNuclear localization signal
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-1823305_312727.3333333333334857.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-1823622_629727.3333333333334857.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-1621305_312538.3333333333334668.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-1722305_312621.3333333333334751.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-1722305_312636.3333333333334766.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-1722622_629636.3333333333334766.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-1621622_629538.3333333333334668.0Nucleotide bindingATP
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-1722622_629621.3333333333334751.0Nucleotide bindingATP


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Fusion Gene Sequence for NVL-ZPBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000391875_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3385nt_BP=2151nt
CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG
AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG
AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT
CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA
ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC
CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT
CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG
GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTA
AAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGC
TCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGA
AGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAG
AGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACCC
CCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTA
CAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATAT
GCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTC
ACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAA
TGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCA
CTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCA
TTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGG
CAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTG
GATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGAC
TAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCA
AGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAG
TGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATAT
ATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGA
TTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTT
TGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTA
TGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTTTTACCACAAGGTCTTGTATAGGGAGATACAATGATGTAT
TCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCATGCCATGTCATAGAGCCATCATATAAATGCCATTCTGTTG
AAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTAATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGAT
CTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCT
ACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTG
GAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTC
AGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGC
ATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGA
CCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAG
TGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTA

>In-frame_ENST00000391875_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=997AA_start in transcript=56_stop in transcript=3049
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLS
KKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFT
TRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRI
EDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQTCVSVLTYGAKSCPQTSN

--------------------------------------------------------------
>In-frame_ENST00000391875_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3171nt_BP=2151nt
CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG
AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG
AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT
CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA
ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC
CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT
CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG
GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTA
AAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGC
TCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGA
AGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAG
AGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACCC
CCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTA
CAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATAT
GCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTC
ACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAA
TGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCA
CTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCA
TTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGG
CAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTG
GATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGAC
TAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCA
AGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAG
TGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATAT
ATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGA
TTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTT
TGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTA
TGGTCTTTGTTAATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATACCACTAATCATAATATCCTCC
AGGCAAGAGATCGAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTG
TGGACCACAGTTTGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTT
GTGTGGTTTGTAGTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTT
GCCCACAAACTTCAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGAT
TTTCACATCCCAGAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAA
TAAATGGTTAACATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTA
ATGAAATGTTTTATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTATAGTAAGGTCAAGAAGAGTATCAAAGTATAATAAAATAA

>In-frame_ENST00000391875_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=924AA_start in transcript=56_stop in transcript=2830
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLS
KKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFVNPFAPGWKGACNGSV
DCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQT

--------------------------------------------------------------
>In-frame_ENST00000391875_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=4137nt_BP=2151nt
CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG
AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG
AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT
CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA
ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC
CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT
CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG
GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTA
AAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGC
TCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGA
AGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAG
AGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACCC
CCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTA
CAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATAT
GCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTC
ACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAA
TGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCA
CTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCA
TTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGG
CAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTG
GATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGAC
TAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCA
AGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAG
TGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATAT
ATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGA
TTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTT
TGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTA
TGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTTTTACCACAAGGTCTTGTATAGGGAGATACAATGATGTAT
TCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCATGCCATGTCATAGAGCCATCATATAAATGCCATTCTGTTG
AAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTAATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGAT
CTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCT
ACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTG
GAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTC
AGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGC
ATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGA
CCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAG
TGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTA
TAGTAAGGTCAAGAAGAGTATCAAAGTATAATAAAATAAAAATTGTATACTCTCCATATATTTATTTGTTTGGAATCACTCTTGTGTGAT
ATAAAGGCGTGTATATTATCTTTGTATTAGAACCAAAAAAGTTATTTATTTTGGTCCCTATGATTTTATTTTTTAAGATAAATTAATATA
CTGTATTTTTTAAAGTATAGGTTTAGGTTTACAGAATAATAGAGCAGATAATATATAGAGTTCCATACACCCACTGCACCCCATACCCTC
ATTCCTCCTTACACAATTTCTCCTATTATTAAGATGGTGCATTAGTGTGGCACATTTGTTACAAATGATGAACCAATATTAATTTATTAT
TAATTATAGCCCATAGTTCACATTAAGATTCATTGTGTTGTAAGGTTATGTGGGTTTTGACAAATTCATAATGGCATGTGTGCACCATTG
CAGTCTCATACAGAATAGTTTCACCACCCTCAAAATCCTGTGCTTCACTTATTTATCCCTCCCGCCGTGCCCTGGCAACCACTGATCTTT
TTACTGTCTCTACAGTTTTGCCTTTTCCAAAATGTCATGTAGTTGGTTGGAGTTATGCAGTATGTAGACTTTTTAGACTGGCTTCTTTCA
CTTAGCAATATGCATTTAAGGTTCCTCCATGTCTTTTTGTGACTTGATAGCTCATTTTTTATTGCTGAATAATGTTCATTGTATGGATAT

>In-frame_ENST00000391875_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=997AA_start in transcript=56_stop in transcript=3049
MQGSWIINSSSESSSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHM
NSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKD
SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPR
GVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL
TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR
EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR
EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGES
ERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLS
KKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFT
TRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRI
EDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQTCVSVLTYGAKSCPQTSN

--------------------------------------------------------------
>In-frame_ENST00000281701_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3676nt_BP=2442nt
AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT
TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC
GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA
GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG
TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA
GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA
ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC
TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA
GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG
ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG
AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG
CTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACAT
TAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC
ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGA
TTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTG
ATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATG
ATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGG
GAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC
CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGT
GTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGG
AAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGG
AGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCA
CTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC
CAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGG
CTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGC
GACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAG
AGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCA
CTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAG
TGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGG
TGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAG
TCAAAAAGAGATATGACTTTATGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTTTTACCACAAGGTCTTGTA
TAGGGAGATACAATGATGTATTCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCATGCCATGTCATAGAGCCAT
CATATAAATGCCATTCTGTTGAAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTAATCCTTTTGCGCCGGGGT
GGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTC
GGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGG
ATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTC
CTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAAT
ATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTC
CATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGG
CATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTAT

>In-frame_ENST00000281701_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=1038AA_start in transcript=224_stop in transcript=3340
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCT
LSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLI
HELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHS

--------------------------------------------------------------
>In-frame_ENST00000281701_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3462nt_BP=2442nt
AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT
TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC
GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA
GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG
TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA
GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA
ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC
TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA
GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG
ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG
AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG
CTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACAT
TAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC
ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGA
TTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTG
ATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATG
ATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGG
GAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC
CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGT
GTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGG
AAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGG
AGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCA
CTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC
CAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGG
CTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGC
GACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAG
AGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCA
CTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAG
TGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGG
TGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAG
TCAAAAAGAGATATGACTTTATGGTCTTTGTTAATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATA
CCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAA
CTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTAC
ACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCC
TTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGG
AAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACA
TGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGA
AGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTATAGTAAGGTCAAGAAGAG

>In-frame_ENST00000281701_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=965AA_start in transcript=224_stop in transcript=3121
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCT
LSYKTVKAETQEEKTVKKRYDFMVFVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVV

--------------------------------------------------------------
>In-frame_ENST00000281701_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=4428nt_BP=2442nt
AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT
TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC
GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA
GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG
TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA
GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA
ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC
TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA
GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG
ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG
AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG
CTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAATGATATGACAT
TAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC
ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGA
TTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCACCATGTATCATTTTCATTG
ATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAACTCCTAACCTGCATGGATG
ATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTGAGACGTGCGG
GAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC
CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGT
GTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCATCTAAAGGAGTCCAGGAGG
AAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACCAAGATCCCCTCTCAGAGG
AGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAAGGCTTTGTCA
CTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC
CAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGG
CTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTGAGAGTGAACGTGCTGTGC
GACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTCCTCGAAGATCAGACCGAG
AGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGGTTTTTATTATGGCAGCCA
CTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGCTTTCTAAAAAAGAAATAG
TGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTGAAACTGGACAGCTGATGG
TGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAACTCAAGAAGAAAAAACAG
TCAAAAAGAGATATGACTTTATGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTTTTACCACAAGGTCTTGTA
TAGGGAGATACAATGATGTATTCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCATGCCATGTCATAGAGCCAT
CATATAAATGCCATTCTGTTGAAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTAATCCTTTTGCGCCGGGGT
GGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTC
GGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGG
ATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTC
CTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAAT
ATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTC
CATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGG
CATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTAT
GTTGCTGTGTACCTAAGAGTATAGTAAGGTCAAGAAGAGTATCAAAGTATAATAAAATAAAAATTGTATACTCTCCATATATTTATTTGT
TTGGAATCACTCTTGTGTGATATAAAGGCGTGTATATTATCTTTGTATTAGAACCAAAAAAGTTATTTATTTTGGTCCCTATGATTTTAT
TTTTTAAGATAAATTAATATACTGTATTTTTTAAAGTATAGGTTTAGGTTTACAGAATAATAGAGCAGATAATATATAGAGTTCCATACA
CCCACTGCACCCCATACCCTCATTCCTCCTTACACAATTTCTCCTATTATTAAGATGGTGCATTAGTGTGGCACATTTGTTACAAATGAT
GAACCAATATTAATTTATTATTAATTATAGCCCATAGTTCACATTAAGATTCATTGTGTTGTAAGGTTATGTGGGTTTTGACAAATTCAT
AATGGCATGTGTGCACCATTGCAGTCTCATACAGAATAGTTTCACCACCCTCAAAATCCTGTGCTTCACTTATTTATCCCTCCCGCCGTG
CCCTGGCAACCACTGATCTTTTTACTGTCTCTACAGTTTTGCCTTTTCCAAAATGTCATGTAGTTGGTTGGAGTTATGCAGTATGTAGAC
TTTTTAGACTGGCTTCTTTCACTTAGCAATATGCATTTAAGGTTCCTCCATGTCTTTTTGTGACTTGATAGCTCATTTTTTATTGCTGAA
TAATGTTCATTGTATGGATATAGCATAGTATGTTTATCCATTCGCCCATTAAAGGAAATCTTGATTGCTTCCAGTTTTCAGTGATTAAAA

>In-frame_ENST00000281701_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=1038AA_start in transcript=224_stop in transcript=3340
MAVRAVAWKTDAMKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTEL
EDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKD
SEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQ
ISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRE
LFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA
SRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDEL
QRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGV
LLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTE
MDGLEARQQVFIMAATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCT
LSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLI
HELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHS

--------------------------------------------------------------
>In-frame_ENST00000469075_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3154nt_BP=1920nt
AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG
GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA
TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG
CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA
AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG
TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGG
GAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCC
CTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGA
AAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCAC
CATGTATCATTTTCATTGATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAAC
TCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACC
CTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGT
GCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGT
GCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCAT
CTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACC
AAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCA
AAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATAT
TGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGA
AGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTG
AGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTC
CTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGG
TTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGC
TTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTG
AAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAA
CTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTATGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTT
TTACCACAAGGTCTTGTATAGGGAGATACAATGATGTATTCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCAT
GCCATGTCATAGAGCCATCATATAAATGCCATTCTGTTGAAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTA
ATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATC
GAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTT
TGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTA
GTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTT
CAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCA
GAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAAC
ATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTT
ATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTATAGTAAGGTCAAGAAGAGTATCAAAGTATAATAAAATAAAAATTGTATACT

>In-frame_ENST00000469075_ENST00000348931_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=935AA_start in transcript=11_stop in transcript=2818
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEE
KTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFA
PGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPAT

--------------------------------------------------------------
>In-frame_ENST00000469075_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=2940nt_BP=1920nt
AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG
GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA
TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG
CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA
AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG
TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGG
GAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCC
CTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGA
AAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCAC
CATGTATCATTTTCATTGATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAAC
TCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACC
CTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGT
GCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGT
GCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCAT
CTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACC
AAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCA
AAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATAT
TGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGA
AGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTG
AGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTC
CTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGG
TTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGC
TTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTG
AAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAA
CTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTATGGTCTTTGTTAATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGAT
CTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATCGAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCT
ACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTTTGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTG
GAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTAGTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTC
AGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTTCAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGC
ATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCAGAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGA
CCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAACATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAG
TGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTTATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTA

>In-frame_ENST00000469075_ENST00000584588_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=862AA_start in transcript=11_stop in transcript=2599
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEE
KTVKKRYDFMVFVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNE

--------------------------------------------------------------
>In-frame_ENST00000469075_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(transcript)=3906nt_BP=1920nt
AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG
GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA
TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG
CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA
AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG
TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGCTAAAGCCAGGGGGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGG
GAGGCAATGATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCCGGAGGTGTACCACCACCTGGGCGTCGTGCCCC
CTCGTGGAGTTCTCCTTCATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGGGAACTTGACCTGCCAATTTTGA
AAGTGGCTGCTCCAGAGATTGTGTCTGGAGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTGTGTCAAATGCAC
CATGTATCATTTTCATTGATGAAATTGATGCTATTACCCCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCAAC
TCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGGTCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACC
CTGCTTTGAGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGAAGCATCCAGGGAAAGAATACTTCAAACATTGT
GCAGAAAACTGAGGCTTCCTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTTGGTGCTGATCTCATGGCACTGT
GCCGAGAGGCAGCAATGTGTGCAGTCAATAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGGAAGATTTGCCAT
CTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCCACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGACC
AAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGAATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCA
AAAGGGAAGGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGAAGACATTAGAGAGGAGCTCACCATGGCAATAT
TGGCACCAGTACGCAACCCAGACCAGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTTGCTGGTCCTCCTGGCTGTGGGA
AGACTCTGCTGGCGAAGGCTGTTGCAAATGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACATGTATGTTGGTG
AGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCCAAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATGTC
CTCGAAGATCAGACCGAGAGACAGGGGCAAGTGTCCGAGTGGTGAATCAGCTACTTACAGAGATGGATGGTCTGGAAGCACGCCAGCAGG
TTTTTATTATGGCAGCCACTAACAGGCCAGACAAAATATATGTAGAGTTACATCAAAATAGTCCAGTCCTTATCTGTATGGATTTTAAGC
TTTCTAAAAAAGAAATAGTGGACCCCACCTACTTATGGATTGGGCCTAATGAAAAGACGTTAACAGGAAATAATAGAATAAATATAACTG
AAACTGGACAGCTGATGGTGAAAGATTTTTTGGAGCCTTTGTCTGGACTTTACACATGTACTCTTTCTTATAAGACTGTTAAAGCAGAAA
CTCAAGAAGAAAAAACAGTCAAAAAGAGATATGACTTTATGGTCTTTGCCTATCGGGAACCTGATTATTCATATCAGATGGCTGTACGTT
TTACCACAAGGTCTTGTATAGGGAGATACAATGATGTATTCTTTAGAGTGCTGAAGAAAATCTTGGATAGTCTAATTTCTGATTTGTCAT
GCCATGTCATAGAGCCATCATATAAATGCCATTCTGTTGAAATTCCAGAACATGGCCTCATACATGAGCTATTTATAGCATTTCAAGTTA
ATCCTTTTGCGCCGGGGTGGAAAGGTGCTTGCAATGGATCTGTTGACTGTGAAGATACCACTAATCATAATATCCTCCAGGCAAGAGATC
GAATAGAAGACTTTTTTCGGAGCCAAGCATATATTTTCTACCATAACTTTAATAAAACTCTACCAGCAATGCATTTTGTGGACCACAGTT
TGCAAGTAGTACGTCTGGATAGCTGTCGACCAGGCTTTGGAAAAAATGAACGTCTACACAGTAATTGCGCTAGCTGTTGTGTGGTTTGTA
GTCCTGCGACTTTTAGTCCTGATGTTAATGTAACTTGTCAGACCTGCGTTTCCGTCCTTACCTATGGAGCTAAATCTTGCCCACAAACTT
CAAACAAAAATCAGCAATATGAAGATTAGAGGTGAAAGCATTGTTACTTACTTGTGGAAGTCGGGGACATAAGATGATTTTCACATCCCA
GAGCATCATAGATAGTTCCATTAAGTAAAATCAGTAAGACCAAACCACTGGAAAACATGCATTTTGGAAACTTTAAAATAAATGGTTAAC
ATGGCATTTCTAAGAAGGCATTTAATCCAGTATCTCTAGTGTACAAAGGAAACTTGAAGTTTTAATGGATTATTTTTAATGAAATGTTTT
ATTGTTTACAAACGGTATGTTGCTGTGTACCTAAGAGTATAGTAAGGTCAAGAAGAGTATCAAAGTATAATAAAATAAAAATTGTATACT
CTCCATATATTTATTTGTTTGGAATCACTCTTGTGTGATATAAAGGCGTGTATATTATCTTTGTATTAGAACCAAAAAAGTTATTTATTT
TGGTCCCTATGATTTTATTTTTTAAGATAAATTAATATACTGTATTTTTTAAAGTATAGGTTTAGGTTTACAGAATAATAGAGCAGATAA
TATATAGAGTTCCATACACCCACTGCACCCCATACCCTCATTCCTCCTTACACAATTTCTCCTATTATTAAGATGGTGCATTAGTGTGGC
ACATTTGTTACAAATGATGAACCAATATTAATTTATTATTAATTATAGCCCATAGTTCACATTAAGATTCATTGTGTTGTAAGGTTATGT
GGGTTTTGACAAATTCATAATGGCATGTGTGCACCATTGCAGTCTCATACAGAATAGTTTCACCACCCTCAAAATCCTGTGCTTCACTTA
TTTATCCCTCCCGCCGTGCCCTGGCAACCACTGATCTTTTTACTGTCTCTACAGTTTTGCCTTTTCCAAAATGTCATGTAGTTGGTTGGA
GTTATGCAGTATGTAGACTTTTTAGACTGGCTTCTTTCACTTAGCAATATGCATTTAAGGTTCCTCCATGTCTTTTTGTGACTTGATAGC
TCATTTTTTATTGCTGAATAATGTTCATTGTATGGATATAGCATAGTATGTTTATCCATTCGCCCATTAAAGGAAATCTTGATTGCTTCC

>In-frame_ENST00000469075_ENST00000377940_TCGA-D1-A3JP-01A_NVL_chr1_224455736_-_ZPBP2_chr17_38026947_length(amino acids)=935AA_start in transcript=11_stop in transcript=2818
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG
EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGND
MTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCII
FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKL
RLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPL
SEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL
AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIM
AATNRPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEE
KTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFA
PGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPAT

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Fusion Gene PPI Analysis for NVL-ZPBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-18231_220727.3333333333334857.0RPL5
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-16211_220538.3333333333334668.0RPL5
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-17221_220621.3333333333334751.0RPL5
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-17221_220636.3333333333334766.0RPL5
HgeneNVLchr1:224455736chr17:38026947ENST00000281701-1823267_474727.3333333333334857.0WDR74
HgeneNVLchr1:224455736chr17:38026947ENST00000340871-1621267_474538.3333333333334668.0WDR74
HgeneNVLchr1:224455736chr17:38026947ENST00000391875-1722267_474621.3333333333334751.0WDR74
HgeneNVLchr1:224455736chr17:38026947ENST00000469075-1722267_474636.3333333333334766.0WDR74


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NVL-ZPBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NVL-ZPBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZPBP2C0004238Atrial Fibrillation1CTD_human
TgeneZPBP2C0235480Paroxysmal atrial fibrillation1CTD_human
TgeneZPBP2C2585653Persistent atrial fibrillation1CTD_human
TgeneZPBP2C3468561familial atrial fibrillation1CTD_human