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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NXN-VPS53 (FusionGDB2 ID:60835)

Fusion Gene Summary for NXN-VPS53

check button Fusion gene summary
Fusion gene informationFusion gene name: NXN-VPS53
Fusion gene ID: 60835
HgeneTgene
Gene symbol

NXN

VPS53

Gene ID

64359

55275

Gene namenucleoredoxinVPS53 subunit of GARP complex
SynonymsNRX|RRS2|TRG-4HCCS1|PCH2E|hVps53L|pp13624
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionnucleoredoxinnucleoredoxin 1vacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunit
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336868, ENST00000577098, 
ENST00000575801, ENST00000538650, 
ENST00000537628, 		ENST00000437048, 
ENST00000574029, ENST00000576149, 
ENST00000446250, ENST00000291074, 
ENST00000571805, ENST00000401468, 
Fusion gene scores* DoF score16 X 13 X 11=228813 X 13 X 8=1352
# samples 2316
** MAII scorelog2(23/2288*10)=-3.31438128583401
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1352*10)=-3.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NXN [Title/Abstract] AND VPS53 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNXN(722678)-VPS53(465985), # samples:1
NXN(722679)-VPS53(465985), # samples:1
VPS53(613773)-NXN(729318), # samples:1
Anticipated loss of major functional domain due to fusion event.NXN-VPS53 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NXN-VPS53 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NXN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VPS53 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3SPNXNchr17

722678

-VPS53chr17

465985

-
ChimerDB4BLCATCGA-FD-A3SP-01ANXNchr17

722679

-VPS53chr17

465985

-


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Fusion Gene ORF analysis for NXN-VPS53

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336868ENST00000437048NXNchr17

722678

-VPS53chr17

465985

-
5CDS-intronENST00000336868ENST00000574029NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000576149NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000446250NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000291074NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000571805NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000401468NXNchr17

722678

-VPS53chr17

465985

-
intron-3CDSENST00000577098ENST00000437048NXNchr17

722678

-VPS53chr17

465985

-
intron-intronENST00000577098ENST00000574029NXNchr17

722678

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000576149NXNchr17

722678

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000446250NXNchr17

722678

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000291074NXNchr17

722678

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000571805NXNchr17

722678

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000401468NXNchr17

722678

-VPS53chr17

465985

-
Frame-shiftENST00000575801ENST00000437048NXNchr17

722678

-VPS53chr17

465985

-
5CDS-intronENST00000575801ENST00000574029NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000576149NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000446250NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000291074NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000571805NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000401468NXNchr17

722678

-VPS53chr17

465985

-
Frame-shiftENST00000538650ENST00000437048NXNchr17

722678

-VPS53chr17

465985

-
5CDS-intronENST00000538650ENST00000574029NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000576149NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000446250NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000291074NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000571805NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000401468NXNchr17

722678

-VPS53chr17

465985

-
In-frameENST00000537628ENST00000437048NXNchr17

722678

-VPS53chr17

465985

-
5CDS-intronENST00000537628ENST00000574029NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000576149NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000446250NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000291074NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000571805NXNchr17

722678

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000401468NXNchr17

722678

-VPS53chr17

465985

-
Frame-shiftENST00000336868ENST00000437048NXNchr17

722679

-VPS53chr17

465985

-
5CDS-intronENST00000336868ENST00000574029NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000576149NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000446250NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000291074NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000571805NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000336868ENST00000401468NXNchr17

722679

-VPS53chr17

465985

-
intron-3CDSENST00000577098ENST00000437048NXNchr17

722679

-VPS53chr17

465985

-
intron-intronENST00000577098ENST00000574029NXNchr17

722679

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000576149NXNchr17

722679

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000446250NXNchr17

722679

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000291074NXNchr17

722679

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000571805NXNchr17

722679

-VPS53chr17

465985

-
intron-5UTRENST00000577098ENST00000401468NXNchr17

722679

-VPS53chr17

465985

-
Frame-shiftENST00000575801ENST00000437048NXNchr17

722679

-VPS53chr17

465985

-
5CDS-intronENST00000575801ENST00000574029NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000576149NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000446250NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000291074NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000571805NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000575801ENST00000401468NXNchr17

722679

-VPS53chr17

465985

-
Frame-shiftENST00000538650ENST00000437048NXNchr17

722679

-VPS53chr17

465985

-
5CDS-intronENST00000538650ENST00000574029NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000576149NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000446250NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000291074NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000571805NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000538650ENST00000401468NXNchr17

722679

-VPS53chr17

465985

-
In-frameENST00000537628ENST00000437048NXNchr17

722679

-VPS53chr17

465985

-
5CDS-intronENST00000537628ENST00000574029NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000576149NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000446250NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000291074NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000571805NXNchr17

722679

-VPS53chr17

465985

-
5CDS-5UTRENST00000537628ENST00000401468NXNchr17

722679

-VPS53chr17

465985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537628NXNchr17722678-ENST00000437048VPS53chr17465985-123176716841856390
ENST00000537628NXNchr17722679-ENST00000437048VPS53chr17465985-123176716841856390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537628ENST00000437048NXNchr17722678-VPS53chr17465985-0.0015268890.9984731
ENST00000537628ENST00000437048NXNchr17722679-VPS53chr17465985-0.0015268890.9984731

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Fusion Genomic Features for NXN-VPS53


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NXN-VPS53


check button Go to

FGviewer for the breakpoints of chr17:722678-chr17:465985

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNXNchr17:722678chr17:465985ENST00000336868-58167_321273.3333333333333436.0DomainThioredoxin
HgeneNXNchr17:722678chr17:465985ENST00000537628-58167_32124.333333333333332187.0DomainThioredoxin
HgeneNXNchr17:722678chr17:465985ENST00000575801-58167_321165.33333333333334328.0DomainThioredoxin
HgeneNXNchr17:722679chr17:465985ENST00000336868-58167_321273.3333333333333436.0DomainThioredoxin
HgeneNXNchr17:722679chr17:465985ENST00000537628-58167_32124.333333333333332187.0DomainThioredoxin
HgeneNXNchr17:722679chr17:465985ENST00000575801-58167_321165.33333333333334328.0DomainThioredoxin
TgeneVPS53chr17:722678chr17:465985ENST00000291074111897_138408.6666666666667671.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:722678chr17:465985ENST00000437048122297_138437.6666666666667833.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:722678chr17:465985ENST00000571805121997_138437.6666666666667700.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:722679chr17:465985ENST00000291074111897_138408.6666666666667671.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:722679chr17:465985ENST00000437048122297_138437.6666666666667833.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:722679chr17:465985ENST00000571805121997_138437.6666666666667700.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for NXN-VPS53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000537628_ENST00000437048_TCGA-FD-A3SP_NXN_chr17_722678_-_VPS53_chr17_465985_length(transcript)=12317nt_BP=671nt
ACCGGAACCGAGCAACGGTAACTGTGCCCCTTCACCGGAACCGAGCAATGGCAGACGTGTCCCTTCACCGGAACCCAGCAACGGTAACTG
TGTCCTTTCACCGAAACTGAGCAATGGTTAACGTGTTTCCTCACTCAGTTCCCAGGCATTGCTGCTGCTGATCTGGGGAACACACTGTAT
GAGCCTGACATAAACCTCTACAGAGCTCTGTCTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGC
CACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTT
CAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTT
CTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGA
GATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGA
GGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGAACCTCGGAGAGCTGATAGATCGGTTTGTGGCTGATTTCAAAGCCCAG
GGGCCACCTAAGCCCAACACTGATGAAGGGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGTCTACTACAAGAAGTGCATGGTGCAA
TGCTCTCAGCTCAGTACTGGGGAGCCCATGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCGAGAATACGCCTGGAAAATCCTCTCT
GGCAACCTGCCCAAAACCACAACCAGCAGTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAAGGAGGGCTCAGAAGTAGCCAAGTTC
ACTCTGGAGGAGCTCTGCCTCATCTGTAACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCACCCAGCAGCTAGAAGAAAAACTCAAA
GAAAAAGTGGATGTAAGTCTGATTGAACGAATCAATCTGACTGGAGAGATGGACACGTTCAGCACCGTCATCTCCAGCAGTATTCAGCTG
CTGGTTCAGGATCTGGATGCTGCCTGTGATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAG
AGCCCCTACGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACT
CAGTTCTGCGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAA
CAGCTGCTGCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGC
TACACCAAGATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTT
GACAACTACATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGC
AGCATGCTGGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCA
GAGCAAGAGTCGTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAG
ACCCTCAGCGCCCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATG
TGGGTTGTTACTGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATT
TAGGTGATCTCTGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCA
CACCCTCTTGACACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGG
AGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACA
GGCGTGAGCCACCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACT
TGGAAGACGTTTCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACC
TTCAGGTCCACAGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAG
TCTGGGGTTCTGGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCC
GCCCTTCCTGTCCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGG
CAGCATATCAAGCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGC
TGTTGCTGCCTGCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGG
AGGATCACTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCA
CCTGTAGTCCCAACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAA
AAATACAAAAAATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGA
ATTCGAGACCAGCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATC
CCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGC
CTGGGTGACAGAGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGT
AGGAATAAGGTTTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCT
CTCTGCCAGGCTTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTT
GACTCTCACGCATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTA
TTAGGAAAAGATTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCAT
GGAGTTGCTATGGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTG
TCCTCAACCCAGGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCT
TTTTGGTTCATTGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACA
GCCAGGGAAGTTGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCC
TTGATGGGGACTCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGAT
GCCGGCCGGGCGCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATC
CTTGCCAATATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGA
CTCTATCTCAAAACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCC
ATAGGTAGTTATAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATAC
ATGTCTATTTTTCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGC
TTTCATTTTAAACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAG
GTCACGAGTTTGAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGG
CGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCG
CCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCT
CTCTCCATACTGATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTAT
CAAAGGGGCACCCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAG
GACTTCAAGACAAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCA
CTTTGGGAGGCCGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAAT
ACAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGA
GGCTGCAGTGAGCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCT
GTGGATGAAAGCAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCC
CTTTAAAAACCAAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTC
TTACTGAGGGGACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGC
AATGGACAAGGTGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAG
TACCCAGGGCTCTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGC
AGACAAGCTGAGACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAA
CCCTTCCTGAATTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGG
GTTCCTTCTCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATG
GGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAA
TGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGA
AATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTG
GAAATGGGGTTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGC
TGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCT
GCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAAC
CTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATA
ACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAA
TAACCTGCTGGAAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGG
AATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTC
AGAACAACCTGCCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCA
ATGGGCAATTTAAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAA
AAATTCCCAGTCCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAAT
AAAGGGATTGCTTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTT
AATTAAAGCATTACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGT
CCGTGACCCTGGCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGA
GCCCAGTCCTGACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTG
TGAATTTCTATCCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCC
TGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATT
TCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTT
TCAACAGGGGAAAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTT
ACTAGGGAAGCCAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTC
ACCTATGTGAACAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGAT
TGGAAGCATCCACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCA
TTTTCAATATTGGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGC
AGTGTGAAGTGTGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACA
AATCCTGCGGCCGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTA
CACGAGAGTTTTAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGA
AGAGAGCTTCCTCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTG
CCAAAGCCTCCCTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCC
TTTCTTTTTCTTTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAG
ATTAACTTGGGACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGAC
TTTTCCCAAGGCCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAAC
CTGGGGCAATATGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGC
TTCTGCTCAGTCATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTC
TCAACAAACTTCCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAG
AAACCCCAGCTCCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTT
CACAAAATCAAGCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAG
AAAACATCTGTTTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAG
CCCCCCACAACCTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCA
TGCCTGTCACATCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGG
AGTGGAGGTCAGTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGC
CTGGGCAATTCAGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCAT
CGGATGAAATTCCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCC
TAGTGAGGGGTGAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTC
ATATGGGACTAGTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAG
CCAGGATTCGATATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTG
AGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATG
TGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGA
TTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGC
GAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTG
GTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCA
GGATTTGATATGTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAG
GGGTGAGCCAGGATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTG
ACCAGTGAGGGGCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATT
TGATATGTGGCTACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTC
AGCCAGGATTCGATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAG
TGAGGGGTGAGCCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATA
TGTGGCTAGTAAGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGA
GGCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAG
TGAGGGGTGAGCCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGT
ACTTCACCAGCAGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATT
TTATGAGTTCAAATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGA
TGAAAATGTGTGTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAG

>In-frame_ENST00000537628_ENST00000437048_TCGA-FD-A3SP_NXN_chr17_722678_-_VPS53_chr17_465985_length(amino acids)=390AA_start in transcript=684_stop in transcript=1856
MIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSL
LKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSK
MQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPS
ISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGAE

--------------------------------------------------------------
>In-frame_ENST00000537628_ENST00000437048_TCGA-FD-A3SP-01A_NXN_chr17_722679_-_VPS53_chr17_465985_length(transcript)=12317nt_BP=671nt
ACCGGAACCGAGCAACGGTAACTGTGCCCCTTCACCGGAACCGAGCAATGGCAGACGTGTCCCTTCACCGGAACCCAGCAACGGTAACTG
TGTCCTTTCACCGAAACTGAGCAATGGTTAACGTGTTTCCTCACTCAGTTCCCAGGCATTGCTGCTGCTGATCTGGGGAACACACTGTAT
GAGCCTGACATAAACCTCTACAGAGCTCTGTCTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGC
CACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTT
CAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTT
CTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGA
GATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGA
GGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGAACCTCGGAGAGCTGATAGATCGGTTTGTGGCTGATTTCAAAGCCCAG
GGGCCACCTAAGCCCAACACTGATGAAGGGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGTCTACTACAAGAAGTGCATGGTGCAA
TGCTCTCAGCTCAGTACTGGGGAGCCCATGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCGAGAATACGCCTGGAAAATCCTCTCT
GGCAACCTGCCCAAAACCACAACCAGCAGTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAAGGAGGGCTCAGAAGTAGCCAAGTTC
ACTCTGGAGGAGCTCTGCCTCATCTGTAACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCACCCAGCAGCTAGAAGAAAAACTCAAA
GAAAAAGTGGATGTAAGTCTGATTGAACGAATCAATCTGACTGGAGAGATGGACACGTTCAGCACCGTCATCTCCAGCAGTATTCAGCTG
CTGGTTCAGGATCTGGATGCTGCCTGTGATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAG
AGCCCCTACGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACT
CAGTTCTGCGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAA
CAGCTGCTGCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGC
TACACCAAGATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTT
GACAACTACATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGC
AGCATGCTGGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCA
GAGCAAGAGTCGTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAG
ACCCTCAGCGCCCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATG
TGGGTTGTTACTGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATT
TAGGTGATCTCTGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCA
CACCCTCTTGACACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGG
AGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACA
GGCGTGAGCCACCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACT
TGGAAGACGTTTCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACC
TTCAGGTCCACAGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAG
TCTGGGGTTCTGGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCC
GCCCTTCCTGTCCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGG
CAGCATATCAAGCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGC
TGTTGCTGCCTGCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGG
AGGATCACTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCA
CCTGTAGTCCCAACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAA
AAATACAAAAAATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGA
ATTCGAGACCAGCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATC
CCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGC
CTGGGTGACAGAGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGT
AGGAATAAGGTTTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCT
CTCTGCCAGGCTTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTT
GACTCTCACGCATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTA
TTAGGAAAAGATTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCAT
GGAGTTGCTATGGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTG
TCCTCAACCCAGGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCT
TTTTGGTTCATTGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACA
GCCAGGGAAGTTGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCC
TTGATGGGGACTCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGAT
GCCGGCCGGGCGCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATC
CTTGCCAATATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGA
CTCTATCTCAAAACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCC
ATAGGTAGTTATAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATAC
ATGTCTATTTTTCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGC
TTTCATTTTAAACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAG
GTCACGAGTTTGAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGG
CGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCG
CCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCT
CTCTCCATACTGATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTAT
CAAAGGGGCACCCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAG
GACTTCAAGACAAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCA
CTTTGGGAGGCCGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAAT
ACAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGA
GGCTGCAGTGAGCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCT
GTGGATGAAAGCAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCC
CTTTAAAAACCAAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTC
TTACTGAGGGGACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGC
AATGGACAAGGTGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAG
TACCCAGGGCTCTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGC
AGACAAGCTGAGACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAA
CCCTTCCTGAATTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGG
GTTCCTTCTCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATG
GGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAA
TGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGA
AATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTG
GAAATGGGGTTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGC
TGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCT
GCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAAC
CTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATA
ACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAA
TAACCTGCTGGAAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGG
AATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTC
AGAACAACCTGCCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCA
ATGGGCAATTTAAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAA
AAATTCCCAGTCCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAAT
AAAGGGATTGCTTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTT
AATTAAAGCATTACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGT
CCGTGACCCTGGCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGA
GCCCAGTCCTGACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTG
TGAATTTCTATCCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCC
TGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATT
TCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTT
TCAACAGGGGAAAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTT
ACTAGGGAAGCCAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTC
ACCTATGTGAACAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGAT
TGGAAGCATCCACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCA
TTTTCAATATTGGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGC
AGTGTGAAGTGTGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACA
AATCCTGCGGCCGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTA
CACGAGAGTTTTAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGA
AGAGAGCTTCCTCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTG
CCAAAGCCTCCCTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCC
TTTCTTTTTCTTTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAG
ATTAACTTGGGACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGAC
TTTTCCCAAGGCCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAAC
CTGGGGCAATATGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGC
TTCTGCTCAGTCATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTC
TCAACAAACTTCCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAG
AAACCCCAGCTCCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTT
CACAAAATCAAGCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAG
AAAACATCTGTTTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAG
CCCCCCACAACCTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCA
TGCCTGTCACATCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGG
AGTGGAGGTCAGTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGC
CTGGGCAATTCAGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCAT
CGGATGAAATTCCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCC
TAGTGAGGGGTGAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTC
ATATGGGACTAGTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAG
CCAGGATTCGATATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTG
AGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATG
TGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGA
TTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGC
GAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTG
GTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCA
GGATTTGATATGTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAG
GGGTGAGCCAGGATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTG
ACCAGTGAGGGGCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATT
TGATATGTGGCTACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTC
AGCCAGGATTCGATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAG
TGAGGGGTGAGCCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATA
TGTGGCTAGTAAGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGA
GGCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAG
TGAGGGGTGAGCCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGT
ACTTCACCAGCAGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATT
TTATGAGTTCAAATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGA
TGAAAATGTGTGTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAG

>In-frame_ENST00000537628_ENST00000437048_TCGA-FD-A3SP-01A_NXN_chr17_722679_-_VPS53_chr17_465985_length(amino acids)=390AA_start in transcript=684_stop in transcript=1856
MIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSL
LKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSK
MQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPS
ISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGAE

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Fusion Gene PPI Analysis for NXN-VPS53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NXN-VPS53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NXN-VPS53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNXNC0009402Colorectal Carcinoma1CTD_human
HgeneNXNC0009404Colorectal Neoplasms1CTD_human
HgeneNXNC1849334Robinow syndrome, autosomal recessive1ORPHANET
TgeneVPS53C4014488PONTOCEREBELLAR HYPOPLASIA, TYPE 2E3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneVPS53C0266468Congenital pontocerebellar hypoplasia1GENOMICS_ENGLAND
TgeneVPS53C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneVPS53C0557874Global developmental delay1GENOMICS_ENGLAND
TgeneVPS53C3714756Intellectual Disability1GENOMICS_ENGLAND